CN1565591A

CN1565591A - Preparation and usage of

Info

Publication number: CN1565591A
Application number: CNA031456677A
Authority: CN
Inventors: 童玉新; 叶正良; 顾菲菲; 陈亮; 叶寿山; 孙延林
Original assignee: Tianjin Tasly Pharmaceutical Co Ltd
Current assignee: Tasly Pharmaceutical Group Co Ltd
Priority date: 2003-07-07
Filing date: 2003-07-07
Publication date: 2005-01-19
Anticipated expiration: 2023-07-07
Also published as: CN100339101C

Abstract

The invention relates to the preparation and use of 'Huoxiang Zhengqi' dripping pills, which are prepared from Chinese medicinal herbs including atractylodes rhizome, dried orange peel, magnolia bark, dahurian angelica root, Poria cocos, pinellia tuber, glycyrrhiza extract, patchouli, purple perilla leaf oil, and polyethyleneglycol.

Description

The preparation method and its usage of ageratum drop pill

Technical field

What the present invention relates to is the preparation that is prepared drop pill by the Chinese medicinal plant extract, specifically is the preparation method and its usage of ageratum dropping pill formulation.

Background technology

The ageratum prescription comes from " formulary of peaceful benevolent dispensary volume two " contained huoxiang zhengqi powder, and main medicine is formed Herba Pogostemonis, Rhizoma Atractylodis, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Pericarpium Arecae, the Radix Angelicae Dahuricae, Folium Perillae, Poria, Pericarpium Citri Reticulatae, Radix Platycodonis, Radix Glycyrrhizae.Have in the harmony in the exterior of separating, the effect of eliminating turbid pathogen with aromatics is mainly used in affection of exogenous wind-cold, in humidity hysteresis is arranged or experiences heat-damp in summer, see exterior syndromes such as cold and heat headache outward, in have vexed, the indigestion and loss of appetite vomiting and nausea of breast abdominal distention, stomachache have loose bowels tastelessness greasy fur, the card of wet resistance such as relaxed and soft pulse.We are usually used in common cold of gastrointestinal type, acute gastroenteritis or dyspepsia etc. and have above-mentioned patient.In addition, the treatment that this prescription is used for pestilence (epidemic diseases) is offered promptly on the books at ancient Chinese prose, and " Wang Kentang is said, and epidemic disease person is that the air-flow that day row is ferocious and stern is capable as " Treatise on Febrile Diseases detailed outline volume seven ".The not positive person of all 4 o'clock orders is to have this gas also capable.If the people feels it, then long children is similar and sick, infects mutually again, and its work is similar to typhoid fever.Right typhoid fever gets because of cold, and this is a pestilential pathogen, can not discuss also together with cold, and method is when warding off diffusing pestilential pathogen, and it is main setting upright gas.Ruo Duori does not understand, and what disease of the pathogenic heat change of disease should become in the disease bar from typhoid fever and select for use.It is then different only to disperse medicine.All decoctions of dispersing, huoxiang zhengqi powder ...All available.”

Rhizoma Atractylodis belong to drying damp and strengthening spleen class Chinese medicine, its main component is a volatile oil, main component is atractylol (Hineso), atisine chloride atractydin (Atractylodin) in the volatile oil, β-eucalyptol (β-Eudesmol machilol) and micro-atractylone (Atractylon).Modern pharmacological research proof Rhizoma Atractylodis have antiulcer action, and gastric secretion is all had remarkable inhibitory action, and effective ingredient β-eucalyptol and atractylol can suppress the activity of " insufficiency of the spleen " animal intestinal propulsion in the Rhizoma Atractylodis, to diarrhea.

Pericarpium Citri Reticulatae belongs to QI regulating medicine, and Chinese medicine thinks that it has the circulation of qi promoting spleen invigorating, the drying dampness to eliminate phlegm effect.Its effective ingredient is hesperidin (Neohes-peridin), Fructus Citri grandis Fructus Citri tangerinae element (Tangeretin), oxedrine (Sgnephrine).Modern pharmacology proof Pericarpium Citri Reticulatae all has inhibitory action to small intestinal and gastrointestinal, and the effective ingredient hesperidin of Pericarpium Citri Reticulatae can suppress the ileum motion.

Cortex Magnoliae Officinalis belongs to QI regulating medicine, and the traditional Chinese medical science thinks that it has promoting the circulation of QI to remove dampness, lowering the adverse QI to relieve asthma effect.Its effective ingredient is magnolol (Magnolol), volatile oil, magnocurarine.Volatile oil mainly is β-eucalyptol (β-Eudesmol machilol).Modern pharmacology proves that the Cortex Magnoliae Officinalis decoct all is excitations to the rabbit intestine in vitro.Mice intestine in vitro and bronchus all are excitation, mice intestine in vitro Cortex Magnoliae Officinalis decoct concentration was manifested excitement at 1: 166 o'clock, and being enlarged at 1: 100 o'clock, concentration transfers inhibition to, effect and mice basically identical to the guinea pig in vitro intestinal tube, but excitation is not obvious, and inhibitory action is more obvious, and behind the special Cortex Magnoliae Officinalis processed with Rhizoma Zingiberis Recens, the anti-gastric-ulcer effect is strengthened.The Cortex Magnoliae Officinalis decoct all has inhibitory action to Bacillus typhi, vibrio cholera, staphylococcus, streptococcus, dysentery bacterium and Bacillus tuberculosis; The leave one's post contraction of heart of animal there is inhibitory action.Magnocurarine is nerve-muscle blocker, and significant skeletal muscle relaxation effect is arranged, and mainly is the transmission of block nerves impulsion at the muscle soleplate, and magnocurarine also has tangible hypotensive effect.

The Radix Angelicae Dahuricae has diffusing wind dehumidifying, understand things pain-stopping, detumescence and apocenosis effect.The Radix Angelicae Dahuricae mainly contains volatile oil and multiple coumarin derivative, Radix Angelicae Dahuricae element (angelicin), oxypeucedanin (oxypeucedanine), phellopterin (phellopterin), xanthotoxin (xanthotoxine), imperatorin, phellopterin, new-Radix Angelicae Dahuricae ether (sen-byakangelicol).Modern pharmacology proves that the Radix Angelicae Dahuricae has antibacterial action and excited central action.

Poria belongs to damp-clearing drug, and the traditional Chinese medical science thinks that it has promoting diuresis to eliminate damp pathogen, and spleen invigorating is calmed the nerves.The chemical constituent of Poria mainly is β-pachyman (β-pach-yman), content reaches as high as 75%, and triterpenoid compound acetyl pachymic acid, pachymic acid (Pachymic acid), eburicoic acid (Ebricoic acid), piece Siberian cocklebur acid (Tumulosic acid), loose Siberian cocklebur acid (Pinicolic acid) etc., still contain ergosterol, choline, acyl purine, lecithin etc. in addition.Modern pharmacology proves that Poria has direct relaxation effect to the stripped intestinal of rabbit, and the smooth muscle contraction amplitude is reduced, and tension force descends, and can reduce gastric secretion and free acid content.

Pericarpium Arecae belongs to QI regulating medicine, and the traditional Chinese medical science thinks that it has therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, the effect of inducing diuresis to remove edema.Its main chemical compositions is with arecoline (Arecoline, C ₈H ₁₃O ₂N) content is maximum, is arecaidine (Arecaidine) secondly, and guvacoline (Guvacoline), demethyl arecaidine (Guvacine) and different demethyl arecaidine (Isoguvacine) etc. still contain tannin, fatty acid etc. in addition.According to relevant documents and materials, Pericarpium Arecae cures mainly therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, and row water, detumescence are mainly used in retention of damp leading to blockage of QI, and gastral cavity abdominal distention is vexed, and it is not well to defecate, edema distension, dysuria.Modern pharmacology proves that the Pericarpium Arecae water decoction can make intestinal tube shrink reinforcement, tonicity raising effect.

The Rhizoma Pinelliae belongs to expectorants, antitussives and anti-asthmatics medicine, and the traditional Chinese medical science thinks that it has the effect of drying dampness to eliminate phlegm stopping nausea and vomiting by lowering the adverse flow of QI dissolving lump and resolving mass.Its main chemical compositions contains volatile oil and each seed amino acid, as contain β-with γ-An Jidingsuan (β-γ-ominbutyric acid), left-handed ephedrine hydrochloride, protocatechualdehyde.The vomiting that Alumen causes Apomorphinum, Folium Digitalis Purpureae, copper sulfate is concocted or added to bibliographical information, Rhizoma Pinelliae heating all has certain town to tell effect, and the effect of digestive system is had the effect of remarkable inhibition gastric secretion, also can suppress gastric juice acid and become.And the Rhizoma Pinelliae has the effect of the bile secretion of promotion to rabbit, can significantly strengthen the intestinal transport ability.

Radix Glycyrrhizae extractum belongs to qi-restoratives medicine, and the traditional Chinese medical science thinks that it has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Its main chemical compositions is glycyrrhizin, enoxolone, flavone compound, mainly be liquiritin (Liquiritin), liquiritigenin (Liquiritigenin), isoliquiritin (Iso-Liquiritin), isoliquiritin unit (Iso-Liquiritigenin), neoliquriitin (Neo-Liquiritin), neoisoliquiritin (Neo-Liquiritin) etc., contain cupreol, formononetin (Formonetin), licoricidin (Licoricidin), the sharp ketone (Licoricone) of Radix Glycyrrhizae and liconeolignan (Liconeo-Lignan) in addition.Modern pharmacology studies have shown that Radix Glycyrrhizae extractum causes ulcer to demonstrate significant inhibition to pylorus ligation.And Radix Glycyrrhizae extractum is given subcutaneous rat administration or intraduodenal administration, and the ulcer incidence rate has been suppressed 40%, and the gastric juice capacity, and free acidity, total acidity all obviously reduce.After 10% Radix Glycyrrhizae extractum 4ml/kg irritates stomach to rabbit, the stomach hypomotility, the stomach motion almost completely stops after 30 minutes.The Cavia porcellus intestinal tube that exsomatizes is spasmolysis, and can removes the enterospasm due to acetylcholine, barium chloride, the histamine.And isoliquiritigenin shows strong spasmolysis.And Radix Glycyrrhizae extractum can promote pancreatic secretion.

Herba Pogostemonis belongs to aromatic damp resolving drug, and the traditional Chinese medical science thinks that it has the effect of expelling summer-heat and damp and middle preventing or arresting vomiting, promoting the circulation of QI to relieve pain.The Herba Pogostemonis chemical constituent mainly contains volatile oil, main constituent is patchouli alcohol (patchoulo alcohol) in the oil, and have α-, β-and γ-Herba Pogostemonis terpenes (α-, β-, γ-patchoulene), α-guaiene (α-guaiene), α-Bu Herba chenopodii alkene (α-bulnesene), Pogostone (pogostone), Flos Caryophylli alkene, eugenol and patchouli pyridine alkali (patchoulipyridine) etc.According to clinical and relevant bibliographical information, the volatile oil of Herba Pogostemonis has eliminating turbid pathogen with aromatics, and the appetizing preventing or arresting vomiting is delivered the effect of expelling summer-heat, is used for the heatstroke heating, headache is uncomfortable in chest, and inappetence is felt sick, and vomiting is had loose bowels.

Folium Perillae belongs to diaphoretic medicine, chemical constituent mainly contains volatile oil, be mainly perillaldehyde (l-perillaldehyde), perilla alcohol (I-perilla-alcohol), limonene, linalool, Mentholum, Flos Caryophylli alkene in the oil, and contain elsholtziakesone (elshottziaketone), perilla ketone, eugenol etc.According to the literature, the water decoction of Folium Perillae has inhibitory action to staphylococcus aureus, and is mainly used in anemofrigid cold, cough, asthma, distension and fullness of the chest and abdomen, vomiting etc.

At present, common clinically ageratum class preparation has pill (watered pill, water-honeyed pill, small honey pill, big honeyed pills, concentrated pill), tablet, mixture, oral liquid, tincture water preparation, bagged steeping drug, water preparation, electuary (granule), capsule (hard, soft capsule) etc.Wherein more welcome with liquid dosage form.But the medicine of this class dosage form normally forms the blend decoction of crude drug through routine, and many effective armaticity volatile ingredient losses affect the treatment in the crude drug because of it can make, so should not adopt.Another kind is in the Pharmacopoeia of the People's Republic of China (1990 editions) the 534th page of records " HUOXIANG ZHENGQI SHUI ", its preparation method is after the raw material that will contain aromatic volatile component earlier is prepared into ethanol percolation liquid with alcohol percolation method, again with the decocting liquid that decocts gained by other raw material and patchouli oil and Folium perillae acutae oil merging, and the pure content that transfers in the finished product with ethanol is 40-50%, thereby this preparation is to contain the higher tincture of alcohol amount.The shortcoming that a large amount of ethanol exist is except that increasing product cost, main is big to GI irritation, the normal sense in clothes back is uncomfortable, even can cause vomiting, not easy for patients to accept, influenced the normal performance of curative effect, to ethanol allergy, or old man, child, and also all should not take the patient of alcohol prohibitions such as heating, vomiting, gastrointestinal ulceration, the scope of treatment target is restricted.Though pill is easy to carry, when taking, effective ingredient discharges slowly, and therapeutical effect is not obvious, is not suitable for being used to the patient who suffers heatstroke, vomits, has loose bowels.

At this situation, the purpose of this invention is to provide a kind of ethanol, drug solubility and dissolution velocity of not containing all increases, is easy to absorb, taking convenience, quality standard height, determined curative effect, therapeutical effect significantly, the preparation method of the ageratum dropping pill formulation that has no side effect.

Summary of the invention

The object of the present invention is to provide a kind of ageratum dropping pill formulation and preparation method thereof.

Another object of the present invention is to provide a kind of and prepare that treatment is caught a cold, vomits, had loose bowels, the application in the heatstroke, cholera, infectious hepatitis, atypical pneumonia disease medicament.

Medicine of the present invention is the drop pill of being made by following bulk drugs, adjuvant:

Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Rhizoma Pinelliae, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil are active component, and wherein the weight ratio of active constituents of medicine and adjuvant Polyethylene Glycol is 1: 1～20; Preferred weight ratio is 1: 1～10; Optimum weight ratio is 1: 3.

The proportioning of the crude drug of preparation active constituents of medicine is: Rhizoma Atractylodis 80～240g, Pericarpium Citri Reticulatae 80～240g, Cortex Magnoliae Officinalis 80～240g, the Radix Angelicae Dahuricae 120～360g, Poria 120～360g, Pericarpium Arecae 120～360g, Rhizoma Pinelliae 80～240g, Radix Glycyrrhizae extractum 10～30g, patchouli oil 0.8～2.4ml, Folium perillae acutae oil 0.4～1.2ml.

The crude drug proportioning of preferred preparation active constituents of medicine is: Rhizoma Atractylodis 120～200g, Pericarpium Citri Reticulatae 120～200g, Cortex Magnoliae Officinalis 120～200g, the Radix Angelicae Dahuricae 180～300g, Poria 180～300g, Pericarpium Arecae 180～300g, Rhizoma Pinelliae 120～200g, Radix Glycyrrhizae extractum 15～25g, patchouli oil 1.2～2.0ml, Folium perillae acutae oil 0.6～1.0ml.

The crude drug proportioning of best preparation active constituents of medicine is: Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis 160g, Radix Angelicae Dahuricae 160g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml.

Said Polyethylene Glycol is selected from Polyethylene Glycol-1000, Polyethylene Glycol-1500, Polyethylene Glycol-4000, Polyethylene Glycol-6000, Polyethylene Glycol-8000 or their mixture in the adjuvant.The Polyethylene Glycol quality standard meets regulation under two each Polyethylene Glycol items of Chinese Pharmacopoeia version in 2000; Adjuvant is preferably Polyethylene Glycol-4000, Polyethylene Glycol-6000 and both mixture thereof; The best is a Polyethylene Glycol-6000.Wherein can contain other does not influence Polyethylene Glycol on a small quantity and returns other solid-state adjuvants at normal temperatures yet, these adjuvants should be in prescription, have favourable or help the pharmaceutic adjuvant of clinical efficacy to stablizing of medicine.

The preparation method of medicine of the present invention comprises the following steps:

(a) by proportioning raw materials take by weighing each crude drug Rhizoma Atractylodis 80～240g, Pericarpium Citri Reticulatae 80～240g, Cortex Magnoliae Officinalis 80～240g, the Radix Angelicae Dahuricae 120～360g, Poria 120～360g, Pericarpium Arecae 120～360g, Rhizoma Pinelliae 80～240g, Radix Glycyrrhizae extractum 10～30g, patchouli oil 0.8～2.4ml, Folium perillae acutae oil 0.4～1.2ml are standby;

(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 12～36 hours with 50～80% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 60～90 ℃ of warm macerating 2 times, 1.5～4.5 hours for the first time, 1～3 hour for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 8～20g, decoct with water 2 times, and 1.5～4.5 hours for the first time, 1～3 hour for the second time; Pericarpium Arecae decocts with water 1.5～4 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;

(c) add Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, mixing;

(d) taking polyethylene glycol heats 60～95 ℃, adds thick paste after the fusion, stirs, and moves in the drop pill machine, keeps the fused solution temperature, from top to bottom, drips moderate the splashing in the condensed fluid of speed, makes drop pill.

Preferred process for preparing medicine of the present invention comprises the following steps:

(a) by proportioning raw materials take by weighing each crude drug Rhizoma Atractylodis 120～200g, Pericarpium Citri Reticulatae 120～200g, Cortex Magnoliae Officinalis 120～200g, the Radix Angelicae Dahuricae 180～300g, Poria 180～300g, Pericarpium Arecae 180～300g, Rhizoma Pinelliae 120～200g, Radix Glycyrrhizae extractum 15～25g, patchouli oil 1.2～2.0ml, Folium perillae acutae oil 0.6～1.0ml are standby;

(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 20～30 hours with 55～65% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 75～85 ℃ of warm macerating 2 times, 2～4 hours for the first time, 1.5～2.5 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 10～15g, decoct with water 2 times, and 2.5～3.5 hours for the first time, 1.5～2.5 hours for the second time; Pericarpium Arecae decocts with water 2.5～3.5 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;

(d) taking polyethylene glycol heats 70～90 ℃, adds thick paste after the fusion, stirs, and moves in the drop pill machine, keeps the fused solution temperature, from top to bottom, drips moderate the splashing in the condensed fluid of speed, makes drop pill.

Best process for preparing medicine of the present invention comprises the following steps:

By the pharmacopeia specified volume get Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 160g, Radix Angelicae Dahuricae 240g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Rhizoma Zingiberis 13.5g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml are standby; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under Chinese Pharmacopoeia nineteen ninety-five version appendix I0 fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 hours, 3 hours for the first time, 2 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and considers liquid and is concentrated into the thick paste shape, adds Radix Glycyrrhizae extractum, and Herba Pogostemonis has, Folium perillae acutae oil, mixing; Get the polyethylene glycol 6000 of 3 times of amounts, heat 70～90 ℃, add thick paste after the fusion, stir, move in the drop pill machine, from top to bottom, splash in 0 ℃～5 ℃ liquid paraffin, make drop pill 1025g.

Wherein Polyethylene Glycol is heated to 60 ℃～100 ℃, and preferred heating-up temperature is 65 ℃～95 ℃, and optimum heating temperature is 70 ℃～90 ℃; The fused solution holding temperature is 40 ℃～110 ℃, and preferred molten liquid holding temperature is 50 ℃～100 ℃, and best fused solution holding temperature is 60 ℃～90 ℃; Condensed fluid is liquid Paraffin, methyl-silicone oil, kerosene or their mixture, and preferred condensed fluid is liquid Paraffin, methyl-silicone oil or their mixture, and best condensed fluid is a liquid Paraffin; The temperature of condensed fluid is 0 ℃～10 ℃, and the temperature of preferred condensed fluid is 0 ℃～8 ℃, and the temperature of best condensed fluid is 0 ℃～5 ℃;

The extraction process of ageratum drop pill Chinese crude drug is consistent with former tincture.Four flavors such as Rhizoma Atractylodis, 60% ethanol percolate extraction; Poria, Rhizoma Pinelliae, Pericarpium Arecae are used water extraction respectively.Be concentrated into thick paste shape (about 234g) after merging medicinal liquid, add Radix Glycyrrhizae extractum, patchouli oil, Oleum Radix Arnebiae (Oleum Radix Lithospermi),, splash in the refrigerative liquid paraffin, promptly with 3 times of fused PEG6000 mixings of amount.The percolation amount of alcohol is to determine with reference to the discrimination test of the color of percolate and the Radix Angelicae Dahuricae, is advisable with 8 times of amounts.

The ethanol consumption Radix Angelicae Dahuricae is differentiated shade

(60%) ++ (obviously)+(more obvious) ± (not obvious)

5 times ++ dark

6 times ++ dark

7 times+darker

8 times+school is shallow

9 times ± shallow

10 times ± shallow

During continuous production, can continue to collect rare liquid of filtering, so carry out, can fully leach and utilize effective ingredient in the medical material, shorten the operating time as the leaching solvent of another batch medical material.

Polymeric solid dispersion method principle has been adopted in the making of this product, medicine is dissolved in the carrier under the situation of heating for dissolving, and splashes into immediately in the inconsistent liquid and cool off, because the surface tension relation is shunk the sphere that condensation forms between medicine and the coolant.

According to the characteristic of medicine, finally select the substrate of Polyethylene Glycol-6000 (PEG6000) as drop pill.PEG6000 is water-soluble base commonly used, and stable in properties not with principal agent generation chemical reaction, can be melted into liquid under 60～100 ℃, and the solid that can congeal into again after the quenching keeps solid-state and harmless at normal temperatures.

It is condensing agent that this product is selected liquid paraffin for use, and it with substrate PEG6000 the fusion effect does not take place, and specific gravity range is suitable, and when the drop bottle bore was 2.0/6.2, the pill falling speed was moderate.

Under the prerequisite of the mouldability that guarantees dosage form, stability, the consumption of substrate is few more good more.On single factor screening basis, intend seeing Table 1 by three level designs of three factors orthogonal test table gauge outfit.Carry out overall merit by, dissolve scattered time limit different, three indexs of presentation quality, select best technology collocation the ball method of double differences in the preparation process.

Table 1 orthogonal test factor level table

Factor A C D

Horizontal ointment: substrate is dripped system temperature (℃) chilling temperature (℃)

1 1∶2 70 0

2 1∶3 80 5

3 1∶4 90 10

Press table 1 and arrange 9 experiments by orthogonal table L9 (34), after the substrate thawing, add the ointment mixing of regulation ratio, be coolant with the liquid paraffin, in set point of temperature and following system of drop bottle bore 2.0/6.2,, measure the dissolve scattered time limit of each test specimen then with the drop pill drop that forms to the greatest extent and the erasing liquor paraffin body, that is, appoint and to get 20 and weigh and obtain the coefficient of variation, and it comprised drip a system mouldability that profile and hardness are marked with ten point system in interior presentation quality, the results are shown in Table 2.

Arrangement of table 2 orthogonal test and result

The tested number factor index

The heavy coefficient of variation (%) dissolve scattered time limit (min) outward appearance of A B C D ball is quality very

1 1?1?1?1 7 8 6

2 1?2?2?2 7.5 9.7 5

3 1?3?3?3 7.4 6.5 4

4 2?1?2?3 3.2 4 8

5 2?2?3?1 3 4.1 9

6 2?3?1?2 6.5 5.5 7

7 3?1?3?2 7.6 8.5 4

8 3?2?2?3 7 7.1 6

9 3?3?1?1 5 7.3 7

The variance analysis of the heavy coefficient of variation of ball (%): the results are shown in Table 3

The variance analysis of the heavy coefficient of variation of table 3 ball (%)

I?j 21.9 17.8 18.5 15.0 ∑＝54.2

IIj 12.7 17.5 17.7 21.6

IIIj 19.6 18.9 18.0 17.6

SSJ 15.3 0.37 0.11 7.37

Rj 3.07 0.47 0.27 2.2

According to last table as can be known, influence factor's primary and secondary is A＞D, and C classifies error term as, SSe=0.37+0.11=0.48, and the scope of C is at 70～90 ℃.

Table 4

Soruces of variation sum of deviation square degree of freedom variance F value significance

A 15.3 2 7.65 63.75 ▲▲

D 7.37 2 3.685 30.7 ▲▲

Error e 0.48 4 0.12

F _(0.01) ^(2.4)＝18.00

The variance analysis of dissolve scattered time limit the results are shown in Table 5

The variance analysis of table 5 dissolve scattered time limit

Ij 24.2 20.5 20.8 19.4 ∑＝60.7

IIj 13.6 20.9 20.8 23.7

IIIj 22.9 19.3 19.1 17.6

SSJ 22.27 0.45 0.63 6.54

Rj 3.53 0.53 0.57 2.03

According to last table as can be known, influence factor's primary and secondary is A＞D, and C classifies error term as, SSe=0.45+0.63=1.08, and the scope of C is at 70～90 ℃.

Table 6

A 22.27 2 11.135 41.24 ▲▲

D 6.54 2 3.27 12.11 ▲▲

Error e 1.08 4 0.27

F _(0.05) ^(2.4)＝6.94，F _(0.01) ^(2.4)＝18.00

The variance analysis of semblance measure the results are shown in Table 7

The variance analysis of table 7 semblance measure

Ij 15 18 20 22 ∑＝56

IIj 24 20 19 16

IIIj 17 18 17 18

SSJ 14.9 0.93 1.6 6.27

Rj 3 0.67 1 2

According to last table as can be known, influence factor's primary and secondary is A＞D, and C classifies error term as, SSe=0.93+1.6=2.53, and the scope of C is at 70～90 ℃.

Table 8

A 14.9 2 7.45 11.78 ▲▲

D 6.27 2 3.135 4.65 ▲

Error e 2.53 4 0.6325

F _(0.10) ^(2.4)＝4.32，F _(0.05) ^(2.4)＝6.94

In sum, can get following table

The heavy coefficient of variation dissolve scattered time limit of index ball presentation quality

Factor primary and secondary A＞D A＞D A＞D

Optimised process collocation A ₂D ₁A ₂D ₃A ₂D ₁

Substrate: medicinal liquid 1: 31: 31: 3

0 ℃ 10 ℃ 0 ℃ of coolant temperature

The result shows: substrate: medicinal liquid ratio and chilling temperature weigh the coefficient of variation to each ball, dissolve scattered time limit, and presentation quality all has the significance influence, drips the system temperature between 70～90 ℃, and each index is not had the significance influence, and definite at last optimised process is A ₂D ₁And drip the system temperature between 70～90 ℃.

More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.

The present invention adopts the ageratum drop pill of method for preparing for not containing alcoholic acid dropping pill formulation, at first, can cover the penetrating odor of Herba Pogostemonis preparation, is easy to be accepted by the patient; Secondly, the drop pill production process is few, and the cycle is short, the automaticity height, and the production efficiency height, cost is relatively low, is easy to industrialization; The 3rd, the drop pill working condition is easy to control, and the ball method of double differences is different little, and content is more accurate, and quality is guaranteed; The 4th, drop pill is convenient to transportation, is stored, and is the form of Chinese drug of country's recommendation at present.Owing to do not conform to ethanol in the final products, not only reduced cost economically, and guaranteeing that " HUOXIANG ZHENGQI SHUI " with the pharmacopeia regulation has on the basis of identical function and curative effect, curative effect in some aspects is better than this " HUOXIANG ZHENGQI SHUI ", and side effect aspects such as gastrointestinal stimulation are but reduced.

For a better understanding of the present invention, below by experiment example further set forth the beneficial effect of invention medicine, experimental example comprises the pharmacodynamics animal experiment of medicine of the present invention (to call the ageratum drop pill in the following text).Test is intended to further specify the effect of ageratum drop pill below, but not limitation of the present invention.The invention medicine that this experimental example adopts is to be prepared from by embodiment 9.

Experimental example: the pharmacodynamic experiment of ageratum drop pill

Experiment material

1, experimental drug: ageratum drop pill (hereinafter to be referred as " healthy energy drop pill "), every bag of 2.5g contains crude drug 3.37g.Connection medical sci-tech development corporation, Ltd. provides by the Shen, Hefei.Lot number: 970312.For the ease of administration, grind before the use, cross 100 mesh sieves, the dextrin that adds a little dissolving back, distilled water heating back reuse 2% earlier is mixed with variable concentrations suspension standby (make experiment make each dosage group administration volume identical).HUOXIANG ZHENGQI SHUI (hereinafter to be referred as " positive air water "), every 10ml contains crude drug 6.74g.Produce by Jiangsu Lianyungang Pharmaceutical Factory.Lot number: 970518.The suspension that medical 2% dextrin is mixed with respective concentration during use standby (irritating body of stomach with the same dosage group of ageratum drop pill when making experiment amasss identical).

2, laboratory animal: mice is provided by this experimental animal room, and pigeon is the market purchase.The animal quality certification: No. 1, the real moving accurate word of gastral cavity doctor.Equal one week of breeding observing of animal before the experiment.

3, acecoline: Shanghai the 8th pharmaceutical factory produces, lot number: 710819.

4, barium chloride: analytical pure, Hunan pharmaceutical factory produces, lot number: 860918.

5, copper sulfate: Changsha chemical reagent factory product, lot number: 740301.

Experimental technique and result

One, to the influence of white mice small intestinal charcoal end propelling rate

Experiment is selected white mice in the healthy Kunming for use, body weight 22-25g, male and female half and half, female unpregnancy.Be divided into three dosage of model control group (dextrin) HUOXIANG ZHENGQI SHUI matched group (2.25g crude drug/kg " down with ") and ageratum drop pill high, normal, basic (4.5,2.25 and 1.125g crude drug/kg " down with ") at random.Every group of 20 animals.Thorough fasting is 12 hours before each white mice experiment, can't help water.。During experiment behind the different group gastric infusions of each white mice eucalyptus globulus after 1 hour, all irritate stomach and give 5% Insta-Char (arabic gum preparation) 0.2ml/20g body weight with 10%, put to death animal after 20 minutes, cut open the belly and carefully take out small intestinal, be not tiled on the flat board with not adding traction, the length of measurement from the pylorus to the caecum is the small intestinal length overall, measure again that the front end to charcoal end reach is that the charcoal end advances length from pylorus, and calculate percentage rate (being that the charcoal end the advances percentage rate) result that its length accounts for the small intestinal length overall and carry out the statistical procedures rank rear in table 1

The influence of table 1 pair white mice small intestinal charcoal end propelling rate (X ± SD)

Group number of animals dosage small intestinal total length advances length propelling rate

(only) be (cm) (cm) (%) (g/kg)

Solvent matched group 20 2% dextrin 49.55 ± 6.26 25.73 ± 4.21 52.51 ± 9.49%

Positive air water group 20 2.25 50.50 ± 7.13 21.83 ± 3.34 43.82 ± 8.47% ^▲

Healthy energy drop pill group 20 4.50 49.20 ± 7.17 19.65 ± 3.61 40.0 ± 5015% ^{▲ ▲}

Healthy energy drop pill group 20 2.25 49.48 ± 7.01 19.90 ± 2.63 40.55 ± 5.44% ^{▲ ▲}

Healthy energy drop pill group 20 1.125 49.45 ± 7.96 21.93 ± 3.80 44.68 ± 6.68% ^▲

Compare with the solvent matched group: ^▲P＜0.05; ^{▲ ▲}＜0.01

Two, effect is told in the town that copper sulfate is caused pigeon vomiting

Healthy pigeon is selected in experiment for use, body weight 256-305g, and male and female are regardless of.Be divided into three dosage groups of model control group (dextrin), HUOXIANG ZHENGQI SHUI matched group (2.25g/kg) and ageratum drop pill high, normal, basic (4.50,2.25 and 1.125g/kg) at random.Every group of 10 pigeons.Each pigeon gastric infusion 2% copper sulfate 20ml/kg, the number of times of vomiting reaction in incubation period and 1 hour of pigeon vomiting is respectively organized in immediate record, and the result carries out statistical procedures, lists in table 2.

Table 2 pair copper sulfate causes the influence (X ± SD) of pigeon vomiting

Group number of animals dosage is vomitted and is vomitted number of times incubation period

(only) be (branch) (inferior/hour) (g/kg)

Solvent matched group 10 2% dextrin 8.91 ± 1.54 13.3 ± 6.86

Positive air water group 10 2.25 9.76 ± 1.93 16.5 ± 6.87

Healthy energy drop pill group 10 4.50 14.39 ± 5.62 ^{▲ ▲ ※}10.8 ± 5.45 ^※

Healthy energy drop pill group 10 2.25 12.98 ± 4.40 ^{▲ ※}11.1 ± 4.12 ^※

Healthy energy drop pill group 10 1.125 11.78 ± 3.82 12.0 ± 3.74

Compare with the solvent matched group: ^▲P＜0.05; ^{▲ ▲}P＜0.01; Compare with HUOXIANG ZHENGQI SHUI ^※P＜0.05

Table 2 result shows: the ageratum drop pill, the pigeon vomiting that copper sulfate causes is told effect by stronger town; And HUOXIANG ZHENGQI SHUI does not only have the town and tells effect, and can increase the vomiting number of times of pigeon in the unit interval.This may be to contain the alcoholic acid cause of 40-50% in the former dosage form.It is more outstanding to improve dosage form advantage in this respect.

Three, to mice acetic acid twisting method analgesic activity

Healthy Kunming kind white mice, body weight 22-25g, male and female half and half, female unpregnancy are selected in experiment for use.Be divided into three dosage groups of model control group (2% dextrin), HUOXIANG ZHENGQI SHUI matched group (2.25g/kg) and ageratum drop pill high, normal, basic (4.50,2.25 and 1.125g/kg) at random.Each white mice is tested last average daily gastric infusion twice (the upper and lower noon of proxima luce (prox. luc) respectively once), after experiment was administered once the same day again, each mice by intraperitoneal injection 0.6% acetum 0.1ml/10g body weight, observe immediately after injecting acetic acid to the time that the animal writhing response occurs (for turning round body incubation period) and in 10 minutes animal the number of times of body appears turning round.Calculate the analgesia percentage rate.The result carries out the statistical procedures rank rear in table 3.

Table 3 ageratum drop pill is to white mice acetic acid twisting analgesic activity (X ± SD)

Group number of animals dosage is turned round body and is turned round body number of times analgesia rate incubation period

(only) (g/kg) (branch) (inferior/hour) be (%)

Model control group 20 2% dextrin 2.27 ± 0.96 33.85 ± 8.86/

Positive air water group 20 2.25 2.42 ± 0.94 27.60 ± 7.04 ^▲15.51%

Healthy energy drop pill group 20 4.50 3.09 ± 1.06 ^※21.30 ± 7.17 ^{▲ ▲}37.08%

Healthy energy drop pill group 20 2.25 2.48 ± 1.08 23.90 ± 8.23 ^{▲ ▲}29.39%

Healthy energy drop pill group 20 1.125 2.38 ± 0.96 26.10 ± 7.04 ^▲22.89%

Compare with model control group: ^▲P＜0.05; ^{▲ ▲}P＜0.01; Compare with HUOXIANG ZHENGQI SHUI ^※P＜0.05

Four, to the influence in white mice gastric emptying time

Healthy Kunming kind white mice, body weight 20-22g, male and female half and half, female unpregnancy are selected in experiment for use.Be divided into three dosage groups of model control group (2% dextrin), HUOXIANG ZHENGQI SHUI matched group (2.25g/kg) and ageratum drop pill high, normal, basic (4.50,2.25 and 1.125g/kg) at random.The experiment proxima luce (prox. luc) by different group gastric infusions once after, thoroughly water is can't help in fasting 24 hours (removing bedding and padding), is administered once before the experiment again, every Mus is irritated stomach and gives 0.1% methyl orange aqueous solution 0.2ml after 4 hours, puts to death animal after 20 minutes, wins stomach, place beaker, use NaHCO ₃Regulate PH6-6.5, separate supernatant,, add the 10ml distilled water with 0.1% methyl orange 0.2ml and make the density radix with day island proper Tianjin UV-240 spectrophotometer (wavelength 420nm), respectively organize methyl orange OD value in the white mice stomach, and the eucalyptus globulus formula is calculated the average stomach residual rate of respectively organizing white mice.The result carries out the statistical procedures rank rear in table 4.

Table 4 ageratum drop pill is to the influence of methyl orange emptying in the white mice stomach (X ± SD)

Methyl orange residual rate in the group number of animals dosage stomach

(only) be (%) (g/kg)

Solvent matched group 15 2% dextrin 38.51 ± 7.99

Positive air water group 15 2.25 37.09 ± 9.15

Healthy energy drop pill group 15 4.50 37.75 ± 8.30

Healthy energy drop pill group 15 2.25 37.25 ± 8.12

Healthy energy drop pill group 15 1.125 36.01 ± 9.53

Compare with model control group:＞P0.05;

Five, in-vitro antibacterial experiment

Staphylococcus aureus (ATCC25923), pathogenic large intestine Erichsen bacterium (ATCC25922) salmonella typhi (ATCC28344), Fu Shi Shiga bacillus (51536) are selected in experiment for use, identify that by the Ministry of Public Health pharmaceutical biological product institute provides.Culture medium: Nutrient agar, chemical reagent work of shanghai Medicine assay office; Prepare 10% SBA+calf serum meat soup and self-control nutrient broth+10% calf serum meat soup with Nutrient agar.Above-mentioned strain transferred species in blood plate, is got the bacterium colony kind in 35 ℃ of 5h of meat soup pipe, and preparation is into about 1.5 * 10 ⁸Cfu/ml is equivalent to 0.5 Maxwell pipe, 10 in row's test tube, and every pipe adds caseinhydrolysate culture medium 1ml, adds medicine 1ml (0.5g/ml) in first test tube and mixes, and inhales 1ml in second test tube, doubling dilution to the nine pipes, the tenth pipe compares group.Get bacterium liquid 1ml 35 ℃ of 24h in first pipe.Other gets culture medium 1ml and adds medicine 1ml and make medicine blank group.Because Chinese medicine is relatively more muddy, so need every pipe is inoculated on the blood plate after cultivating 24h, observation has or not bacterial growth, the results are shown in table 5,6.

The experiment of table 5 ageratum drop pill in-vitro antibacterial

Strain ageratum drop pill concentration (g/ml) medicine bacterial strain

0.5 0.25 0.125 0.0625 0.0313 0.0157 0.0078 contrast contrast

Staphylococcus aureus-++++++-+

Salmonella typhi---++++-+

Shigella flexneri--+++++-+

Escherichia coli----+++-+

Annotate: "+" expression has bacterial growth in the table; The no bacterial growth of "-" expression.

The experiment of table 6 HUOXIANG ZHENGQI SHUI in-vitro antibacterial

Strain ageratum water concentration (g/ml) medicine 45% ethanol bacterial strain

0.5 0.25 0.125 0.0625 0.0313 0.0157 0.0078 contrast contrast contrast

Staphylococcus aureus-++++++--+

Salmonella typhi---++++--+

Shigella flexneri---++++--+

Escherichia coli-----++--+

Conclusion

1, the ageratum drop pill has obvious inhibition white mice charcoal end propelling rate, compares P＜0.05～0.01 with the model group matched group.

2, copper sulfate causes the pigeon vomiting, and the ageratum drop pill has stronger town to tell effect; And HUOXIANG ZHENGQI SHUI does not only have the town and tells effect, has increased the vomiting number of times of pigeon in the unit interval on the contrary, and this may be that to contain the ethanol of 40-50% in the HUOXIANG ZHENGQI SHUI relevant.

3, ageratum drop pill and HUOXIANG ZHENGQI SHUI cause pain to white mice acetic acid twisting method a stronger analgesic activity, its turn round in body incubation period and 10 minutes turn round the body number of times and model need compare: P＜0.05～0.01.

4, ageratum drop pill and HUOXIANG ZHENGQI SHUI do not have obvious influence to methyl orange residual rate in the white mice stomach, compare P＞0.05 with model control group.

5, the in-vitro antibacterial experiment shows: ageratum drop pill and HUOXIANG ZHENGQI SHUI all have inhibitory action in various degree to staphylococcus aureus, pathogenic colon bacillus, salmonella typhi, Fu Shi Shiga bacillus.But to the effect of Fu Shi Bacillus typhi, HUOXIANG ZHENGQI SHUI is stronger slightly than ageratum drop pill, this may with former dosage form in to contain 40～50% ethanol relevant.

The specific embodiment

That below introduce is the embodiment of the inventive method, but the scope of the inventive method is not limited to following example.

Embodiment 1: the preparation of active component of the present invention

By the pharmacopeia specified volume get Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 160g, Radix Angelicae Dahuricae 240g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Rhizoma Zingiberis 13.5g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml are standby:

Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under Chinese Pharmacopoeia nineteen ninety-five version appendix I0 fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 hours, 3 hours for the first time, 2 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and considers the liquid concentrating under reduced pressure and becomes thick paste, adds Radix Glycyrrhizae extractum, patchouli oil, and Folium perillae acutae oil, mixing is made thing active component of the present invention.

Embodiment 2: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-4000,60 ℃ heat fused, add of the present invention thing active component of 50g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 40 ℃ of insulations at the uniform velocity splash in 2 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1500g, promptly.

Embodiment 3: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-4000,65 ℃ heat fused, add of the present invention thing active component of 100g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 50 ℃ of insulations at the uniform velocity splash in 0 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1500g, promptly.

Embodiment 4: the preparation of ageratum drop pill

Get 100g Polyethylene Glycol-4000,90 ℃ heat fused, add of the present invention thing active component of 100g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 100 ℃ of insulations at the uniform velocity splash in 0 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 300g, promptly.

Embodiment 5: the preparation of ageratum drop pill

Get 729g Polyethylene Glycol-4000,80 ℃ heat fused, add of the present invention thing active component of 243g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 80 ℃ of insulations at the uniform velocity splash in 5 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1025g, promptly.

Embodiment 6: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-6000,80 ℃ heat fused, add of the present invention thing active component of 80g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 80 ℃ of insulations at the uniform velocity splash in 5 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1125g, promptly.

Embodiment 7: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-6000,100 ℃ heat fused, add of the present invention thing active component of 125g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 60 ℃ of insulations at the uniform velocity splash in 10 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1500g, promptly.

Embodiment 8: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-6000,90 ℃ heat fused, add of the present invention thing active component of 200g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 110 ℃ of insulations at the uniform velocity splash in 8 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1600g, promptly.

Embodiment 9: the preparation of ageratum drop pill

Get 729g Polyethylene Glycol-6000,90 ℃ heat fused, add of the present invention thing active component of 243g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 80 ℃ of insulations at the uniform velocity splash in 5 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1025g, promptly.

Embodiment 10: the preparation of ageratum drop pill

Get 50g Polyethylene Glycol-6000,90 ℃ heat fused, add of the present invention thing active component of 50g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 80 ℃ of insulations at the uniform velocity splash in 0 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 150g, promptly.

Embodiment 11: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-4000,100 ℃ heat fused, add of the present invention thing active component of 50g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 40 ℃ of insulations at the uniform velocity splash in 6 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1500g, promptly.

Embodiment 12: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-4000 and Polyethylene Glycol-6000 mixture, 70 ℃ of heat fused add of the present invention thing active component of 150g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 100 ℃ of insulations at the uniform velocity splash in 10 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1500g, promptly.

Embodiment 13: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-4000 and Polyethylene Glycol-6000 mixture, 80 ℃ of heat fused add of the present invention thing active component of 90g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 80 ℃ of insulations at the uniform velocity splash in 5 ℃ of methyl-silicone oil condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1150g, promptly.

Embodiment 14: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-4000 and Polyethylene Glycol-6000 mixture, 100 ℃ of heat fused add of the present invention thing active component of 300g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 100 ℃ of insulations at the uniform velocity splash in 5 ℃ of kerosene condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1500g, promptly.

Embodiment 15: the preparation of ageratum drop pill

Get 100g Polyethylene Glycol-1000,100 ℃ heat fused, add of the present invention thing active component of 50g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 80 ℃ of insulations at the uniform velocity splash in 8 ℃ of methyl-silicone oil condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 175g, promptly.

Embodiment 16: the preparation of ageratum drop pill

Get 729g Polyethylene Glycol-1500,100 ℃ heat fused, add of the present invention thing active component of 243g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 90 ℃ of insulations at the uniform velocity splash in 10 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1025g, promptly.

Embodiment 17: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-8000,95 ℃ heat fused, add of the present invention thing active component of 150g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 50 ℃ of insulations at the uniform velocity splash in 0 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1500g, promptly.

Embodiment 18: the preparation of ageratum drop pill

Get 1000g Polyethylene Glycol-1000, Polyethylene Glycol-1500, Polyethylene Glycol-4000, Polyethylene Glycol-6000, Polyethylene Glycol-8000 mixture, 85 ℃ of heat fused add of the present invention thing active component of 100g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 85 ℃ of insulations at the uniform velocity splash in 10 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 1400g, promptly.

Embodiment 19: the preparation of ageratum drop pill

Get 100g Polyethylene Glycol-4000,60 ℃ heat fused, add of the present invention thing active component of 34g according to the preparation of embodiment one method, fully stir and make its complete fusion, be uniformly dispersed, put in the surge drum of drop pill machine, 60 ℃ of insulations at the uniform velocity splash in 5 ℃ of liquid Paraffin condensed fluid, collect drop pill, drop is clean, puts the paraffin on drop pill surface on the skin, places natural drying, make drop pill 160g, promptly.

Embodiment 20: the preparation of ageratum drop pill

By the pharmacopeia specified volume get Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 160g, Radix Angelicae Dahuricae 240g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Rhizoma Zingiberis 13.5g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml are standby; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under Chinese Pharmacopoeia nineteen ninety-five version appendix I0 fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 hours, 3 hours for the first time, 2 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and considers liquid and is concentrated into the thick paste shape, adds Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, mixing; Get the Polyethylene Glycol-6000 of 3 times of amounts, heat 70～90 ℃, add thick paste after the fusion, stir, move in the drop pill machine, keeping the fused solution temperature is 60 ℃～90 ℃, from top to bottom, drips moderate the splashing in 0 ℃～5 ℃ liquid paraffin of speed, makes drop pill 1025g.

Embodiment 21: the preparation of ageratum drop pill

(a) it is standby to take by weighing each crude drug Rhizoma Atractylodis 80g, Pericarpium Citri Reticulatae 80g, Cortex Magnoliae Officinalis 100g, Radix Angelicae Dahuricae 120g, Poria 120g, Pericarpium Arecae 140g, Rhizoma Pinelliae 80g, Radix Glycyrrhizae extractum 10g, patchouli oil 0.8ml, Folium perillae acutae oil 0.5ml by proportioning raw materials;

(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 20 hours with 70% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 70 ℃ of warm macerating 2 times, 4.5 hours for the first time, 3 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 15g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;

(a) add Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, mixing;

(b) get an amount of polyethylene glycol 6000, be heated to 80 ℃, add thick paste after the fusion, stir, move in the drop pill machine, keep 80 ℃ of fused solution temperature, from top to bottom, drip moderate the splashing in 5 ℃ of condensed fluid paraffin of speed, make 5000 drop pills.

Embodiment 22: the preparation of ageratum drop pill

(a) it is standby to take by weighing each crude drug Rhizoma Atractylodis 120g, Pericarpium Citri Reticulatae 200g, Cortex Magnoliae Officinalis 200g, Radix Angelicae Dahuricae 180g, Poria 160g, Pericarpium Arecae 180g, Rhizoma Pinelliae 120g, Radix Glycyrrhizae extractum 15g, patchouli oil 1.2ml, Folium perillae acutae oil 0.8ml by proportioning raw materials;

(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 55% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 times, 4 hours for the first time, 2 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 14g, decoct with water 2 times, and 3.5 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;

(d) get an amount of Macrogol 4000, be heated to 90 ℃, add thick paste after the fusion, stir, move in the drop pill machine, keep 90 ℃ of fused solution temperature, from top to bottom, drip moderate the splashing in 3 ℃ of condensed fluid paraffin of speed, make 5000 drop pills.

Embodiment 23: the preparation of ageratum drop pill

(a) it is standby to take by weighing each crude drug Rhizoma Atractylodis 200g, Pericarpium Citri Reticulatae 180g, Cortex Magnoliae Officinalis 200g, Radix Angelicae Dahuricae 200g, Poria 300g, Pericarpium Arecae 180g, Rhizoma Pinelliae 200g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.2ml, Folium perillae acutae oil 1.0ml by proportioning raw materials;

(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 30 hours with 65% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 85 ℃ of warm macerating 2 times, 3 hours for the first time, 2 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3.5 hours for the first time, 3 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;

(d) get an amount of polyethylene glycol 6000 and Macrogol 4000 mixture, be heated to 95 ℃, add thick paste after the fusion, stir, move in the drop pill machine, keep 85 ℃ of fused solution temperature, from top to bottom, drip moderate the splashing in 5 ℃ of condensed fluid paraffin of speed, make 5000 drop pills.

Embodiment 24: the preparation of ageratum drop pill

(a) it is standby to take by weighing each crude drug Rhizoma Atractylodis 240g, Pericarpium Citri Reticulatae 150g, Cortex Magnoliae Officinalis 240g, Radix Angelicae Dahuricae 360g, Poria 360g, Pericarpium Arecae 300g, Rhizoma Pinelliae 240g, Radix Glycyrrhizae extractum 30g, patchouli oil 2.4ml, Folium perillae acutae oil 1.2 by proportioning raw materials;

(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 times, 4 hours for the first time, 3 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 18.5g, decoct with water 2 times, and 4 hours for the first time, 3 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;

(d) get an amount of polyethylene glycol 6000, be heated to 90 ℃, add thick paste after the fusion, stir, move in the drop pill machine, keep 80 ℃ of fused solution temperature, from top to bottom, drip moderate the splashing in 8 ℃ of condensed fluid paraffin of speed, make 5000 drop pills.

Embodiment 25: the preparation of ageratum drop pill

(a) it is standby to take by weighing each crude drug Rhizoma Atractylodis 240g, Pericarpium Citri Reticulatae 240g, Cortex Magnoliae Officinalis 240g, Radix Angelicae Dahuricae 300g, Poria 360g, Pericarpium Arecae 360g, Rhizoma Pinelliae 240g, Radix Glycyrrhizae extractum 25g, patchouli oil 1.6ml, Folium perillae acutae oil 1.2ml by proportioning raw materials;

(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 36 hours with 75% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 75 ℃ of warm macerating 2 times, 3.5 hours for the first time, 2.5 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 30g, decoct with water 2 times, and 4 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;

(e) get an amount of polyethylene glycol 6000 and polyethylene glycol 1500 mixture, be heated to 85 ℃, add thick paste after the fusion, stir, move in the drop pill machine, keep 85 ℃ of fused solution temperature, from top to bottom, drip moderate the splashing in 5 ℃ of condensed fluid paraffin of speed, make 5000 drop pills.

Embodiment 26: the preparation of ageratum drop pill

(a) it is standby to take by weighing each crude drug Rhizoma Atractylodis 80g, Pericarpium Citri Reticulatae 240g, Cortex Magnoliae Officinalis 200g, Radix Angelicae Dahuricae 120g, Poria 120g, Pericarpium Arecae 360g, Rhizoma Pinelliae 180g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.4ml, Folium perillae acutae oil 1.2ml by proportioning raw materials;

(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 55% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 85 ℃ of warm macerating 2 times, 4 hours for the first time, 3 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 16g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;

(d) get an amount of polyethylene glycol 6000 and Macrogol 4000 mixture, be heated to 85 ℃, add thick paste after the fusion, stir, move in the drop pill machine, keep 85 ℃ of fused solution temperature, from top to bottom, drip moderate the splashing in 8 ℃ of condensed fluid paraffin of speed, make 5000 drop pills.

Embodiment 27: the preparation of ageratum drop pill

(a) it is standby to take by weighing each crude drug Rhizoma Atractylodis 110g, Pericarpium Citri Reticulatae 150g, Cortex Magnoliae Officinalis 200g, Radix Angelicae Dahuricae 180g, Poria 120g, Pericarpium Arecae 240g, Rhizoma Pinelliae 120g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.0ml, Folium perillae acutae oil 0.8ml by proportioning raw materials;

(b) Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 20 hours with 80% ethanol respectively according to the percolation under Chinese Pharmacopoeia fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 60 ℃ of warm macerating 2 times, 3.5 hours for the first time, 2.5 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 15g, decoct with water 2 times, and 3.5 hours for the first time, 1 hour for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape;

(d) get an amount of polyethylene glycol 6000, be heated to 90 ℃, add thick paste after the fusion, stir, move in the drop pill machine, keep 85 ℃ of fused solution temperature, from top to bottom, drip moderate the splashing in 10 ℃ of condensed fluid paraffin of speed, make 5000 drop pills.

Claims

1, a kind of ageratum dropping pill formulation, it is characterized in that said preparation is is active constituents of medicine by Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Rhizoma Pinelliae, Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, add the adjuvant Polyethylene Glycol and make, wherein active constituents of medicine and adjuvant Polyethylene Glycol weight ratio are 1: 1～20.

2, ageratum dropping pill formulation according to claim 1 is characterized in that active constituents of medicine and adjuvant Polyethylene Glycol weight ratio are 1: 1～10.

3, ageratum dropping pill formulation according to claim 1 is characterized in that active constituents of medicine and adjuvant Polyethylene Glycol weight ratio are 1: 3.

4,, it is characterized in that active constituents of medicine is to be made by following raw materials in weight portion medicine: Rhizoma Atractylodis 80～240g, Pericarpium Citri Reticulatae 80～240g, Cortex Magnoliae Officinalis 80～240g, the Radix Angelicae Dahuricae 120～360g, Poria 120～360g, Pericarpium Arecae 120～360g, Rhizoma Pinelliae 80～240g, Radix Glycyrrhizae extractum 10～30g, patchouli oil 0.8～2.4ml, Folium perillae acutae oil 0.4～1.2ml as the described ageratum dropping pill formulation of claim 1～3.

5, as the described ageratum dropping pill formulation of claim 1～3, it is characterized in that active constituents of medicine is to be made by following raw materials in weight portion medicine, Rhizoma Atractylodis 120～200g, Pericarpium Citri Reticulatae 120～200g, Cortex Magnoliae Officinalis 120～200g, the Radix Angelicae Dahuricae 180～300g, Poria 180～300g, Pericarpium Arecae 180～300g, Rhizoma Pinelliae 120～200g, Radix Glycyrrhizae extractum 15～25g, patchouli oil 1.2～2.0ml, Folium perillae acutae oil 0.6～1.0ml.

6, as the described ageratum dropping pill formulation of claim 1～3, it is characterized in that active constituents of medicine is to be made by following raw materials in weight portion medicine, Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis 160g, Radix Angelicae Dahuricae 160g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml.

7, as the preparation method of claim 1,2 or 3 described ageratum drop pill, it is characterized in that comprising the following steps:

8, as the preparation method of claim 1,2 or 3 described ageratum drop pill, it is characterized in that comprising the following steps:

9,, it is characterized in that comprising the following steps: to get Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 160g, Radix Angelicae Dahuricae 240g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Rhizoma Zingiberis 13.5g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml are standby as the preparation method of claim 1,2 or 3 described ageratum drop pill; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, the Radix Angelicae Dahuricae as solvent, flood and carry out percolation after 24 hours with 60% ethanol respectively according to the percolation under Chinese Pharmacopoeia nineteen ninety-five version appendix I0 fluid extract and the extractum item, collect percolate, reclaim ethanol, and medicinal liquid is standby; Behind the Poria decocting in water, 80 ℃ of warm macerating 2 hours, 3 hours for the first time, 2 hours for the second time, extracting juice; The Rhizoma Pinelliae cold water soak was changed water once in per 8 hours, and bubble is to the saturating heart, and other adds Rhizoma Zingiberis 13.5g, decoct with water 2 times, and 3 hours for the first time, 2 hours for the second time; Pericarpium Arecae decocts with water 3 hours, merges above-mentioned medicinal liquid, filters, and filtrate is concentrated into the thick paste shape, adds Radix Glycyrrhizae extractum, patchouli oil, Folium perillae acutae oil, mixing; Get the Polyethylene Glycol-6000 of 3 times of amounts, heat 70～90 ℃, add thick paste after the fusion, stir, move in the drop pill machine, keeping the fused solution temperature is 60 ℃～90 ℃, from top to bottom, drips moderate the splashing in 0 ℃～5 ℃ liquid paraffin of speed, makes drop pill 1025g.

10, as the preparation method of ageratum dropping pill formulation as described in the claim 7, it is characterized in that Polyethylene Glycol is the mixture of Polyethylene Glycol-4000, Polyethylene Glycol-6000 or Polyethylene Glycol-4000 and Polyethylene Glycol-6000; The Polyethylene Glycol heating-up temperature is 60 ℃～100 ℃; The fused solution holding temperature is 40 ℃～110 ℃; Condensed fluid is liquid Paraffin, methyl-silicone oil, kerosene or their mixture, and the temperature of condensed fluid is 0 ℃～10 ℃.

11, as the preparation method of ageratum dropping pill formulation as described in the claim 7, it is characterized in that Polyethylene Glycol is Polyethylene Glycol-4000 or Polyethylene Glycol-6000; The Polyethylene Glycol heating-up temperature is 65 ℃～95 ℃; The fused solution holding temperature is 50 ℃～100 ℃; Condensed fluid is a liquid Paraffin, and the temperature of condensed fluid is 0 ℃～8 ℃.

12, as the preparation method of ageratum dropping pill formulation as described in the claim 7, it is characterized in that Polyethylene Glycol is a Polyethylene Glycol-6000; The Polyethylene Glycol heating-up temperature is 70 ℃～90 ℃; The fused solution holding temperature is 60 ℃～90 ℃; Condensed fluid is a liquid Paraffin, and the temperature of condensed fluid is 0 ℃～5 ℃.

13,, it is characterized in that this drop pill is caught a cold in the preparation treatment, vomits, had loose bowels, the application in the cholera, heatstroke, infectious hepatitis, atypical pneumonia medicine as the ageratum drop pill of method preparation as described in the claim 8.