CN100349598C - Medicine for treating high lipemia and its production method - Google Patents
Medicine for treating high lipemia and its production method Download PDFInfo
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- CN100349598C CN100349598C CNB2005100566941A CN200510056694A CN100349598C CN 100349598 C CN100349598 C CN 100349598C CN B2005100566941 A CNB2005100566941 A CN B2005100566941A CN 200510056694 A CN200510056694 A CN 200510056694A CN 100349598 C CN100349598 C CN 100349598C
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Abstract
The present invention relates to medicine for treating hyperlipidemia and a production method thereof. The medicine is prepared from the following ingredients by weight parts: 6 to 20 parts of crystal pearl, 6 to 20 parts of prepared fleece flower root, 6 to 20 parts of oriental water plantain rhizome, 6 to 20 parts of hawthorn fruit, 6 to 20 parts of semen cassiae, 4 to 15 parts of five leaf gynostemma herb, 4 to 15 parts of lotus leaf and 4 to 15 parts of chrysanthemum. The production method comprises: A, crushing all of or part of oriental water plantain rhizome, crystal pearl, prepared fleece flower root and five leaf gynostemma herb together into coarse powder, leaching so as to obtain leaching liquid, recovering alcohol and concentrating so as to form thick paste; B, decocting chrysanthemum, lotus leaf, hawthorn fruit and semen cassiae twice in water, filtering, and concentrating filtering liquid into thick paste; C, mixing the two kinds of the thick paste, and preparing the thick paste into medicine according to pharmacy requirements, wherein part of oriental water plantain rhizome is extracted by alcohol, and the rest oriental water plantain rhizome is crushed and is uniformly mixed with the thick paste. The medicine of the present invention has the functions of yin nourishing, heat elimination, liver and kidney nourishing, qi benefit, blood circulation activation and blood fat reduction, and the medicine has good curative effects on hyperlipidemia of a liver-kidney yin-deficiency type, a yin-deficiency and interior-heat type and a qi and blood stasis stagnation type. Clinical experiments show that the medicine has the advantages of safety, reliability, no obvious adverse reactions, no toxicity and no side effects.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of hyperlipemia, particularly relate to the medicine and the production method thereof for the treatment of liver-kidney yin deficiency, type of YIN-deficiency and interior-heat, qi stagnation and blood stasis type hyperlipemia.
Background technology
Along with the raising of living standards of the people, the food intake of higher fatty acid, high heat makes hyperlipemia, coronary atherosclerosis, coronary heart disease, obesity patient in rising trend within the specific limits.Hyperlipemia is because lipid metabolism or running make one or more lipids of blood plasma be higher than normally unusually.Hyperlipemia can show as hypercholesterolemia, hypertriglyceridemia or both have concurrently, can be divided into Primary hyperlipemia and Secondary cases hyperlipemia two big classes clinically.Primary hyperlipemia is rarer, belongs to the heritability metabolic disturbance diseases; The Secondary cases hyperlipemia is common in the bad diabetes of control, drinks, hypothyroidism, nephrotic syndrome, kidney dialysis, renal transplantation, biliary obstruction, oral contraceptive etc.
Though hyperlipemia does not have this medicine name in motherland's medical science, the syndrome of similar hyperlipemia then sporadically appears in successive dynasties doctor nationality, can belong to " phlegm-damp ", " turbid resistance " scope.China tradition traditional Chinese medical science has a lot of treatises to the treatment of hyperlipemia, has also put down in writing the Chinese medicinal formulae of many treatment hyperlipemias, and these prescriptions are one of China's pools of traditional Chinese medicine important compositions according to the different syndromes of hyperlipemia and different.The ancient Chinese medicine theory is fully being summed up, excavating and utilized to the modern Chinese medicine theory also, and many science treatises have also proposed the method and the medicine of a large amount of Chinese traditional treatment hyperlipemias, and the Chinese traditional treatment hyperlipemia has been played directive function preferably.Depend on the bigger Western medicine preparation of some side effect to a great extent and be used for the treatment of medicines such as hyperlipemia at present, some pharmaceutical factories and Chinese medicine institute have also been released the Chinese patent medicine of some treatment hyperlipemias over the years, but the price that these Chinese patent medicines have is higher, patient is difficult to accept, the specific aim that has is not strong, and curative effect is not as people's will.
Summary of the invention
The purpose of this invention is to provide a kind of to hyperlipemia is with strong points, evident in efficacy, prescription is uncomplicated, moderate Chinese patent medicine and production method thereof.
Applicant Lingfeng Pharmaceutical Co., Ltd., Guangxi, from motherland's traditional medical theory, through research for many years, tens kinds of Chinese medicinal formulaes have been screened, compare repeatedly, therefrom choose some medicines and prescription, carried out pharmacodynamics, pharmacology and research experiment such as clinical, finally invented a kind of good effect, medicine source extensively, moderate, production technology advanced feasible, have no side effect, use Chinese patent medicine more easily again, the main active and the weight content of its raw material are as follows:
1～25 part of 2～30 portions of Herb Gynostemmae Pentaphylli of 2～30 portions of Rhizoma Alismatis of 2～30 parts of Radix Polygoni Multiflori Preparatas of Rhizoma Polygonati
1～25 part of 1～25 part of Flos Chrysanthemi of 2～30 parts of Folium Nelumbinis of 2～30 parts of Semen Cassiaes of Fructus Crataegi
Above-mentioned Chinese medicine can be from " finding its another name, latin name and the place of production, usage Chinese pharmacopoeia and other Chinese medicine handbook, in order to understand the mechanism that the present invention treats disease, now respectively distinguish the flavor of in the prescription effect of Chinese medicine and the effect in prescription thereof are described below: the Rhizoma Polygonati yin nourishing, kidney tonifying, spleen invigorating, tonifying the lung; The Herb Gynostemmae Pentaphylli heat-clearing and toxic substances removing, the spleen invigorating of nourishing heart, benefiting qi and removing blood stasis, two medicines share replenishing YIN and removing heat with Zhi Qiben, are monarch drug altogether.The Semen Cassiae liver heat removing and eyesight improving, nourishing the liver and kidney; The Flos Chrysanthemi clearing away heat to improve acuity of vision; Folium Nelumbinis, Rhizoma Alismatis clearing away heat-damp and promoting diuresis; The hawthorn digesting eliminate indigestion, blood circulation promoting and blood stasis dispelling, invigorating middle warmer has logical, and five medicines share principal drug assistance replenishing YIN and removing heat, benefiting qi and removing blood stasis; Radix Polygoni Multiflori Preparata is adjuvant drug, and is warm in nature, enrich and benefit essence and blood.All medicines share, replenishing YIN and removing heat, nourishing the liver and kidney, benefiting QI for activating blood circulation, blood fat reducing.
Chinese medicine composition best in quality umber content of the present invention is:
4～15 parts of 6～20 portions of Herb Gynostemmae Pentaphylli of 6～20 portions of Rhizoma Alismatis of 6～20 parts of Radix Polygoni Multiflori Preparatas of Rhizoma Polygonati
4～15 parts of 4～15 parts of Flos Chrysanthemis of 6～20 parts of Folium Nelumbinis of 6～20 parts of Semen Cassiaes of Fructus Crataegi
The composition of Chinese medicine composition of the present invention and content the best in quality also can adopt following proportioning (weight portion):
Rhizoma Polygonati 12 Radix Polygoni Multiflori Preparatas 12 Rhizoma Alismatis 12 Herb Gynostemmae Pentaphylli 8
Fructus Crataegi 12 Semen Cassiaes 12 Folium Nelumbinis 8 Flos Chrysanthemis 8
Above-mentioned composition can be used as the prescription of institute of traditional Chinese medicine's treatment hyperlipemia, and patients is fried in shallow oil soup and taken; Be more suitable for modern pharmaceutical enterprise and extract its effective ingredient, make capsule, tablet, granule, oral liquid, slow releasing capsule, soft capsule or drop pill, perhaps make any dosage form on the pharmaceutics, concrete production method is as follows:
1, the production method of capsule:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 100～120 ℃ of high pressure steam sterilizations 30～60 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% was made solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(5) get intermediate products A and D and appropriate amount of auxiliary materials mixing, granulate, drying, encapsulated, In Aluminium Foil Packing, packing gets the finished capsule product agent.
2, the production method of tablet:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 100～120 ℃ of high pressure steam sterilizations 30～60 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% was made solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(5) get intermediate products A and D and appropriate amount of auxiliary materials mixing, granulate, drying, tabletting, sugar coating or film-coat, packing gets finished tablet.
3, the production method of granule:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% was made solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(4) get intermediate products D and appropriate amount of auxiliary materials mixing, granulate, drying, packing gets the finished particle agent.
4, the production method of oral liquid:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% was made solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate the intermediate product stream extractum A.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract B.
(3) get intermediate products A and B and an amount of syrup or Mel mixing, sterilization, fill gets the finished product oral liquid.
5, the production method of slow releasing capsule:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 100～120 ℃ of high pressure steam sterilizations 30～60 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% was made solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings decoctions twice together, decocted 1～2 hour at every turn, collecting decoction filters, and concentrate drying gets intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(5) according to the total amount of intermediate products A and D, add spermaceti or other blocker coating of 0.5-5%, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, pack into behind the mix homogeneously in the capsulae vacuus, be packaged into box or be hot pressed into aluminium-plastic panel, obtain the finished product slow releasing capsule.
6, the production method of soft capsule:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% was made solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) B and C are mixed, drying, be ground into fine powder, promptly get intermediate products dry extract D.
(4) get intermediate products dry extract D, vegetable oil, Cera Flava by making suspended matter H at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then suspended matter H fill is pressed into soft capsule, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out the soft capsule that gets product.
7, the production method of drop pill:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 100～120 ℃ of high pressure steam sterilizations 30～60 minutes, intermediate products A.
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% was made solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, promptly get intermediate products dry extract D
2
(5) with the polyethylene glycol 6000 heating and melting, get intermediate products dry extract A and D again and add, stir evenly, be transferred on the drop pill device, 86 ℃ of airtight insulations are made coolant with 10 ℃ of-15 ℃ of liquid paraffin or other liquid, with the 50/component velocity system of dripping, drop pill gets product.
Other dosage form such as pill, unguentum etc. can carry out with reference to pharmacopeia or Chinese medicinal preparation method.
The extracting method of above-mentioned Chinese medicine composition has provided alcohol extraction+water and has carried, except carrying with alcohol extraction+water, can also adopt the extracting method of microwave, ultrasonic extraction, carbon dioxide supercritical fluid extraction or other Chinese medicine preparation, these extracting method have had report in scientific and technical literature, pharmacy corporation can adopt extracting method according to concrete practical situation, its objective is the extracts active ingredients in this medicine medical material, make any dosage form pharmaceutically, just can provide to dose a patient with.
Instructions of taking:
Capsule, oral, one time 4,3 times on the one, every 0.36 the gram.
Tablet, 3 times on the one, one time 6, every 0.45 the gram
Granule, 2 times on the one, each 1 bag, every bag 8 gram
Oral liquid, every day 3 times, each 10ml
Slow releasing capsule, oral, one time 5,1-2 time on the one, every 0.5 the gram.
Soft capsule, oral, one time 4,3 times on the one;
Drop pill, oral, one time 4,3 times on the one;
The present invention compared with the prior art, its outstanding substantive distinguishing features and obvious improvement is:
1, the present invention's preferred above-mentioned Chinese medicine under Chinese medical theory instructs, science compatibility, making in addition, make each medicine cooperatively interact, can guarantee to greatest extent the group effect and the pharmaceutically-active performance of this product reasonable formula, all medicines share, and play the effect of replenishing YIN and removing heat, nourishing the liver and kidney, benefiting QI for activating blood circulation, blood fat reducing altogether.Through clinical verification, the effect that the present invention has blood fat reducing and lengthens one's life.
2, show through China Medicine University's pharmacological research: this medicine reduces respectively the conventional acute and chronic high blood lipid model of mice: cholesterol 43.6% and 59.4%; Beta lipoprotein 72.8% and 92.1% and body weight 6.7%, to some the conventional indications of subacute aging model due to the Cavia porcellus retrobulbar injection d-galactose 40 days as: activity of monoamine oxidase increases in the brain; Brain, the heart, liver lipofuscin increase collection; The defying age effect that blood fat, blood glucose and spleen weight index raise and all have highly significant to reduce; To the skin aging hydroxyproline content, thymic weight index and erythrocyte, hematoblastic reduction also all have the raising protective effect of highly significant, the effect of lengthening the life of housefly are tested show that the effect that this medicine builds up one's health and prolong one's life obviously is better than pollen.
3, raw material is easy to get, the prescription science, and moderate product price is fit to suitability for industrialized production.
4, produce in according to each flavor Effective Components of Chinese Herb character and preparation requirement, adopt that the alcohol extraction of part medical material, part medical material water are carried, the production technology of part pulverizing medicinal materials and corresponding sterilizing methods, thereby product active constituent content height, bioavailability height, and not perishable, long shelf-life.
5, production technology advanced person, workable, according to each flavor Effective Components of Chinese Herb character and preparation requirement, successively adopt international advanced pharmaceutical technology and equipment such as superfine communication technique, multiple-effect decompression technology, spray drying technology, three-dimensional hybrid technology, one-step palletizing technology in the production.
6, the result of product studies on acute toxicity of the present invention and long term toxicity research shows, is safe by intending with using the daily dose and the course of treatment product of the present invention.
The specific embodiment
Below be embodiments of the invention:
Embodiment 1
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 2.4 Radix Polygoni Multiflori Preparatas 2.4 Rhizoma Alismatis 2.4 Herb Gynostemmae Pentaphylli 1.6
Fructus Crataegi 2.4 Semen Cassiaes 2.4 Folium Nelumbinis 1.6 Flos Chrysanthemis 1.6
Its technological process of production is:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 100 ℃ of high pressure steam sterilizations 60 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to fluid extract and extractum item percolation down, makes solvent Jin Stains after 24 hours with 8 times of ethanol of measuring volume by volume concentrations 50%, slow percolation, the collection liquid of filtering, reclaim ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 6 times of water gagings together and decoct twice, decocted two hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(5) get intermediate products A and D and appropriate amount of auxiliary materials mixing, granulate, drying, encapsulated, aluminum-plastic packaged, packing gets finished product, and name of product is " a bright damp capsule ".
Embodiment 2
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 5 Radix Polygoni Multiflori Preparatas 5 Rhizoma Alismatis 5 Herb Gynostemmae Pentaphylli 3.2
Fructus Crataegi 5 Semen Cassiaes 5 Folium Nelumbinis 3.2 Flos Chrysanthemis 3.2
Its technological process of production is:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 110 ℃ of high pressure steam sterilizations 50 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to fluid extract and extractum item percolation down, makes solvent Jin Stains after 24 hours with 5 times of ethanol of measuring volume by volume concentrations 60%, slow percolation, the collection liquid of filtering, reclaim ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 8 times of water gagings together and decoct twice, decocted 1.5 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(4) with B and C, drying, be ground into fine powder, intermediate products dry extract D
(5) get intermediate products A and D and appropriate amount of auxiliary materials mixing, granulate, drying, encapsulated, aluminum-plastic packaged, packing gets finished product, and name of product is " a bright damp capsule ".
Embodiment 3
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 6 Radix Polygoni Multiflori Preparatas 6 Rhizoma Alismatis 6 Herb Gynostemmae Pentaphylli 3
Fructus Crataegi 6 Semen Cassiaes 6 Folium Nelumbinis 3 Flos Chrysanthemis 3
Its technological process of production is:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 120 ℃ of high pressure steam sterilizations 30 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to fluid extract and extractum item percolation down, makes solvent Jin Stains after 24 hours with 7 times of ethanol of measuring volume by volume concentrations 80%, slow percolation, the collection liquid of filtering, reclaim ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 5 times of water gagings together and decoct twice, decocted two hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(5) get intermediate products A and D and appropriate amount of auxiliary materials mixing, granulate, drying, encapsulated, aluminum-plastic packaged, packing gets finished product, and name of product is " a bright damp capsule ".
Embodiment 4
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 2.4 Radix Polygoni Multiflori Preparatas 2.4 Rhizoma Alismatis 2.4 Herb Gynostemmae Pentaphylli 1.5
Fructus Crataegi 2.4 Semen Cassiaes 2.4 Folium Nelumbinis 1.5 Flos Chrysanthemis 1.5
Its technological process of production is:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 115 ℃ of high pressure steam sterilizations 40 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to fluid extract and extractum item percolation down, makes solvent Jin Stains after 24 hours with 4 times of ethanol of measuring volume by volume concentrations 75%, slow percolation, the collection liquid of filtering, reclaim ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 7 times of water gagings together and decoct twice, decocted 1 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D;
(5) get intermediate products A and D and appropriate amount of auxiliary materials mixing, granulate, drying, tabletting, sugar coating or film-coat, packing gets finished product, and name of product is " a bright damp sheet ".
Embodiment 5
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 7.3 Radix Polygoni Multiflori Preparatas 7.3 Rhizoma Alismatis 7.3 Herb Gynostemmae Pentaphylli 4.8
Fructus Crataegi 7.3 Semen Cassiaes 7.3 Folium Nelumbinis 4.8 Flos Chrysanthemis 4.8
Its technological process of production is:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 118 ℃ of high pressure steam sterilizations 45 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 6.5 times of amount volume by volume concentrations 70% was made solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 8 times of water gagings together and decoct twice, decocted 1 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(5) get intermediate products A and D and appropriate amount of auxiliary materials mixing, granulate, drying, tabletting, sugar coating or film-coat, packing gets finished product, and name of product is " a bright damp sheet ".
Embodiment 6
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 9 Radix Polygoni Multiflori Preparatas 8.6 Rhizoma Alismatis 8.8 Herb Gynostemmae Pentaphylli 5
Fructus Crataegi 9.2 Semen Cassiaes 9.4 Folium Nelumbinis 4.3 Flos Chrysanthemis 4.4
Its technological process of production is:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 105 ℃ of high pressure steam sterilizations 55 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to fluid extract and extractum item percolation down, makes solvent Jin Stains after 24 hours with 6 times of ethanol of measuring volume by volume concentrations 55%, slow percolation, the collection liquid of filtering, reclaim ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 8 times of water gagings together and decoct twice, decocted 1.5 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(5) get intermediate products A and D and appropriate amount of auxiliary materials mixing, granulate, drying, tabletting, sugar coating or film-coat, packing gets finished product, and name of product is " a bright damp sheet ".
Embodiment 7
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 2.8 Radix Polygoni Multiflori Preparatas 2.8 Rhizoma Alismatis 2.8 Herb Gynostemmae Pentaphylli 1.8
Fructus Crataegi 2.8 Semen Cassiaes 2.8 Folium Nelumbinis 1.8 Flos Chrysanthemis 1.8
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 5.5 times of ethanol of measuring volume by volume concentrations 65% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 6 times of water gagings together and decoct twice, decocted 2 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(4) get intermediate products D and appropriate amount of auxiliary materials mixing, granulate, drying, packing gets finished product, and name of product is " a bright damp granule ".
Embodiment 8
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 6.2 Radix Polygoni Multiflori Preparatas 6.6 Rhizoma Alismatis 6.24 Herb Gynostemmae Pentaphylli 3
Fructus Crataegi 6.4 Semen Cassiaes 7 Folium Nelumbinis 2.8 Flos Chrysanthemis 3.2
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 7 times of ethanol of measuring volume by volume concentrations 70% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 5 times of water gagings together and decoct twice, decocted 1.5 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(4) get intermediate products D and appropriate amount of auxiliary materials mixing, granulate, drying, packing gets finished product, and name of product is " a bright damp granule ".
Embodiment 9
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 7.2 Radix Polygoni Multiflori Preparatas 7.2 Rhizoma Alismatis 7.5 Herb Gynostemmae Pentaphylli 3.4
Fructus Crataegi 7.5 Semen Cassiaes 8 Folium Nelumbinis 3.8 Flos Chrysanthemis 4
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 6 times of ethanol of measuring volume by volume concentrations 60% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 8 times of water gagings together and decoct twice, decocted 1 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(4) get intermediate products D and appropriate amount of auxiliary materials mixing, granulate, drying, packing gets finished product, and name of product is " a bright damp granule ".
Embodiment 10
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 4.4 Radix Polygoni Multiflori Preparatas 4.4 Rhizoma Alismatis 4.4 Herb Gynostemmae Pentaphylli 2.6
Fructus Crataegi 4.4 Semen Cassiaes 4.4 Folium Nelumbinis 2.6 Flos Chrysanthemis 2.6
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 7 times of ethanol of measuring volume by volume concentrations 50% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 5 times of water gagings together and decoct twice, decocted two hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) get intermediate products B and C and an amount of syrup or Mel mixing, sterilization, fill gets finished product, and name of product is " a bright damp oral liquid ".
Embodiment 11
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 6.6 Radix Polygoni Multiflori Preparatas 5.9 Rhizoma Alismatis 7.3 Herb Gynostemmae Pentaphylli 3
Fructus Crataegi 7.1 Semen Cassiaes 6.9 Folium Nelumbinis 2.9 Flos Chrysanthemis 4.1
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 6 times of ethanol of measuring volume by volume concentrations 55% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 7 times of water gagings together and decoct twice, decocted 2 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) get intermediate products B and C and an amount of syrup or Mel mixing, sterilization, fill gets finished product, and name of product is " a bright damp oral liquid ".
Embodiment 12
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 2.8 Radix Polygoni Multiflori Preparatas 2.6 Rhizoma Alismatis 2.1 Herb Gynostemmae Pentaphylli 2.8
Fructus Crataegi 3.1 Semen Cassiaes 3.8 Folium Nelumbinis 1.9 Flos Chrysanthemis 1.5
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 4 times of ethanol of measuring volume by volume concentrations 80% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 7 times of water gagings together and decoct twice, decocted 1.5 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) get intermediate products B and C and an amount of syrup or Mel mixing, sterilization, fill gets finished product, and name of product is " a bright damp oral liquid ".
Embodiment 13
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 2.4 Radix Polygoni Multiflori Preparatas 2.4 Rhizoma Alismatis 2.4 Herb Gynostemmae Pentaphylli 1.6
Fructus Crataegi 2.4 Semen Cassiaes 2.4 Folium Nelumbinis 1.6 Flos Chrysanthemis 1.6
Its technological process of production is:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 120 ℃ of high pressure steam sterilizations 35 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to fluid extract and extractum item percolation down, makes solvent Jin Stains after 24 hours with 4 times of ethanol of measuring volume by volume concentrations 55%, slow percolation, the collection liquid of filtering, reclaim ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 6 times of water gagings decoctions twice together, decocted 2 hours at every turn, collecting decoction filters, and concentrate drying gets intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D;
(5) according to the total amount of intermediate products A and D, the spermaceti or other blocker coating that add 0.5-5%, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, pack into behind the mix homogeneously in the capsulae vacuus, be packaged into box or be hot pressed into aluminium-plastic panel, obtain finished product, name of product is " the bright damp capsule of slow release " or " bright damp slow releasing capsule ".
Embodiment 14
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 6.5 Radix Polygoni Multiflori Preparatas 7.1 Rhizoma Alismatis 6.3 Herb Gynostemmae Pentaphylli 3.3
Fructus Crataegi 5.4 Semen Cassiaes 5.8 Folium Nelumbinis 2.1 Flos Chrysanthemis 1.2
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 4.5 times of ethanol of measuring volume by volume concentrations 55% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 7 times of water gagings together and decoct twice, decocted 1.5 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) B and C are mixed, drying is ground into fine powder, gets intermediate products dried cream powder D.
(4) according to the total amount of intermediate products D, the spermaceti or other blocker coating that add 0.5-5%, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, pack into behind the mix homogeneously in the capsulae vacuus, be packaged into box or be hot pressed into aluminium-plastic panel, obtain finished product, name of product is " the bright damp capsule of slow release " or " bright damp slow releasing capsule ".
Embodiment 15
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 8.1 Radix Polygoni Multiflori Preparatas 8.6 Rhizoma Alismatis 7.1 Herb Gynostemmae Pentaphylli 5
Fructus Crataegi 6.6 Semen Cassiaes 7.7 Folium Nelumbinis 4.1 Flos Chrysanthemis 3.9
Its technological process of production is:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 110 ℃ of high pressure steam sterilizations 45 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to fluid extract and extractum item percolation down, makes solvent Jin Stains after 24 hours with 7 times of ethanol of measuring volume by volume concentrations 60%, slow percolation, the collection liquid of filtering, reclaim ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 5 times of water gagings decoctions twice together, decocted 2 hours at every turn, collecting decoction filters, and concentrate drying gets intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, intermediate products dry extract D
(5) according to the total amount of intermediate products A and D, the spermaceti or other blocker coating that add 0.5-5%, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, pack into behind the mix homogeneously in the capsulae vacuus, be packaged into box or be hot pressed into aluminium-plastic panel, obtain finished product, name of product is " the bright damp capsule of slow release " or " bright damp slow releasing capsule ".
Embodiment 16
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 2.4 Radix Polygoni Multiflori Preparatas 2.4 Rhizoma Alismatis 2.4 Herb Gynostemmae Pentaphylli 1.6
Fructus Crataegi 2.4 Semen Cassiaes 2.4 Folium Nelumbinis 1.6 Flos Chrysanthemis 1.6
Its technological process of production is:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 116 ℃ of high pressure steam sterilizations 50 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to fluid extract and extractum item percolation down, makes solvent Jin Stains after 24 hours with 6 times of ethanol of measuring volume by volume concentrations 70%, slow percolation, the collection liquid of filtering, reclaim ethanol, concentrate intermediate products fluid extract B.
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 7 times of water gagings together and decoct twice, decocted 2 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(4) B and C are mixed, drying, be ground into fine powder, promptly get intermediate products dry extract D.
(5) get intermediate products dry extract A and D, vegetable oil, Cera Flava by making suspended matter H at 1: 1: 0.02
1, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then with suspended matter H
1Fill is pressed into soft capsule, typing below 25 ℃, and with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, taking-up gets product, and name of product is " a bright damp soft capsule ".
Embodiment 17
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 5.4 Radix Polygoni Multiflori Preparatas 5.9 Rhizoma Alismatis 6.4 Herb Gynostemmae Pentaphylli 2.3
Fructus Crataegi 7 Semen Cassiaes 6.1 Folium Nelumbinis 2 Flos Chrysanthemis 2.5
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 5 times of ethanol of measuring volume by volume concentrations 65% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B
2
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 6.5 times of water gagings together and decoct twice, decocted 1.5 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C
2
(3) with B
2And C
2Mix, drying is ground into fine powder, gets intermediate products dried cream powder D
2
(4) get intermediate products dry extract D
2, vegetable oil, Cera Flava be by making suspended matter H at 1: 1: 0.02
1, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then with suspended matter H
1Fill is pressed into 1000 soft capsules, typing below 25 ℃, and with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, taking-up gets product, and name of product is " a bright damp soft capsule ".
Embodiment 18
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 6 Radix Polygoni Multiflori Preparatas 7 Rhizoma Alismatis 6.5 Herb Gynostemmae Pentaphylli 3
Fructus Crataegi 6.6 Semen Cassiaes 7.1 Folium Nelumbinis 2.5 Flos Chrysanthemis 2
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 6.5 times of ethanol of measuring volume by volume concentrations 60% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 7 times of water gagings together and decoct twice, decocted 2 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) B and C are mixed, drying is ground into fine powder, gets intermediate products dried cream powder D.
(4) get intermediate products dry extract D, vegetable oil, Cera Flava by making suspended matter H at 1: 1: 0.02
1, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then with suspended matter H
1Fill is pressed into soft capsule, typing below 25 ℃, and with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, taking-up gets product, and name of product is " a bright damp soft capsule ".
Embodiment 19
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 2.4 Radix Polygoni Multiflori Preparatas 2.4 Rhizoma Alismatis 2.4 Herb Gynostemmae Pentaphylli 1.6
Fructus Crataegi 2.4 Semen Cassiaes 2.4 Folium Nelumbinis 1.6 Flos Chrysanthemis 1.6
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 7 times of ethanol of measuring volume by volume concentrations 55% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 5 times of water gagings together and decoct twice, decocted 2 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) B and C are mixed, drying is ground into fine powder, gets intermediate products dried cream powder D.
(4) with the polyethylene glycol 6000 heating and melting, getting intermediate products dry extract D again adds, stir evenly, be transferred on the drop pill device, 86 ℃ of airtight insulations are made coolant with 10 ℃ of-15 ℃ of liquid paraffin or other liquid, with the 50/component velocity system of dripping, get product, name of product is " a bright damp drop pill ".
Embodiment 20
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 5.2 Radix Polygoni Multiflori Preparatas 4.9 Rhizoma Alismatis 3.7 Herb Gynostemmae Pentaphylli 2.5
Fructus Crataegi 8 Semen Cassiaes 6.1 Folium Nelumbinis 3.2 Flos Chrysanthemis 2.4
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 8 times of ethanol of measuring volume by volume concentrations 50% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3 times of water gagings together and decoct twice, decocted 1.5 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) with B
2And C
2Mix, drying is ground into fine powder, gets intermediate products dried cream powder D.
(4) with the polyethylene glycol 6000 heating and melting, getting intermediate products dry extract D again adds, stir evenly, be transferred on the drop pill device, 86 ℃ of airtight insulations are made coolant with 10 ℃ of-15 ℃ of liquid paraffin or other liquid, with the 50/component velocity system of dripping, get product, name of product is " a bright damp drop pill ".
Embodiment 21
Take by weighing following Chinese medicine ingredients (unit: g)
Rhizoma Polygonati 4 Radix Polygoni Multiflori Preparatas 4.1 Rhizoma Alismatis 3.7 Herb Gynostemmae Pentaphylli 3
Fructus Crataegi 7 Semen Cassiaes 6.1 Folium Nelumbinis 2 Flos Chrysanthemis 2.4
Its technological process of production is:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder,, make solvent Jin Stains after 24 hours, slow percolation, the collection liquid of filtering with 5 times of ethanol of measuring volume by volume concentrations 80% according to fluid extract and extractum item percolation down, reclaim ethanol, concentrate intermediate products fluid extract B.
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 6 times of water gagings together and decoct twice, decocted 2 hours at every turn, collecting decoction filters, concentrate intermediate products fluid extract C.
(3) B and C are mixed, drying is ground into fine powder, gets intermediate products dried cream powder D.
(4) with the polyethylene glycol 6000 heating and melting, getting intermediate products dry extract D again adds, stir evenly, be transferred on the drop pill device, 86 ℃ of airtight insulations are made coolant with 10 ℃ of-15 ℃ of liquid paraffin or other liquid, with the 50/component velocity system of dripping, get product, name of product is " a bright damp drop pill ".
Below be clinical research report of the present invention:
Medicine of the present invention entrusts provincial, and municipal level three tame hospitals to carry out clinical verification, and job step and experimental result are as follows:
Clinical data:
One, physical data:
The clinical verification case is totally 246 examples, and wherein 166 examples are organized in treatment, matched group 80 examples.Male's 105 examples in the treatment group, women's 61 examples, maximum 85 years old age, minimal ages 33 years old, 57.91 ± 9.26 years old mean age; Male's 51 examples in the matched group, women's 29 examples, maximum 79 years old age, minimal ages 40 years old, 55.53 ± 8.48 years old mean age.Treatment group and matched group verify that respectively the case distribution of pattern of syndrome sees Table 1.
Table 1 A: treatment group B: matched group
| The hepatic and renal YIN deficiency | Interior-heat caused by deficiency of YIN | Qi depression to blood stasis | Hyperlipidemia | ||||
| A | 65 | A | 21 | A | 40 | A | 40 |
| B | 30 | B | 10 | B | 20 | B | 20 |
Two, diagnostic criteria
1, serum total cholesterol (TC) 6.0mMol/L;
2, serum levels of triglyceride (TG) 1.24mMol/L;
3, serum high-density LP (HDL-C)＜1.17mMol/L.
Three, case is selected
1, the age has 1 person of hyperlipemia diagnostic criteria more than 30 years old;
2, have one of following situation person should not include the object of observation in:
(1) once suffered from acute myocardial infarction, cerebrovascular accident, severe trauma or capital operation person in half a year;
(2) patients such as hypothyroidism, acute and chronic liver and gall diseases, diabetes, pancreas disease and gout;
(3) using heparin, thyroid medicine and other to influence blood lipid metabolism medicine patient.
Four, observational technique adopt district's group at random, controlled observation.
1, experimenter's routine is done physical examination and the check of every serum lipids before the treatment, selects case on request.Observe 246 examples altogether, wherein 166 examples are organized in treatment, matched group 80 examples.Look into the random digit permutation table, treatment group and matched group were by 2: 1,3: 2 or 5: 3 district's group random packet;
2, treatment group each each 4, took for 4 weeks, the every serum lipids of end back check with " bright damp capsule ", matched group continuously with " Max EPA capsule " every day 3 times;
3, take medicine after the beginning, weekly with examining 1 time, the situation after the inquiry medication has no adverse reaction and toxic and side effects;
4, press efficacy assessment standard, evaluate therapeutic effect, directly make by observing the doctor with integration method;
5, require experimenter's medication on time, full diet during the medication is forbidden all fat-reducing medicaments.
Five, efficacy assessment standard
1, blood fat increases classification
(1) slight:＜normal value ± (TC1.3mMol/L; TG0.55mMol/L; HDL-C1.3mMol/L)
(2) moderate:＞normal value ± (TC2.6mMol/L; TG1.1mMol/L; HDL-C2.6mMol/L)
(3) severe:＞normal value ± (TC3.9mMol/L; TG1.6mMol/L; HDL-C3.9mMol/L)
2, blood fat curative effect classification
(1) slight blood fat rising (or reduction)
Produce effects: blood fat increases (subtracting) and reaches normal level;
Invalid: blood fat increases (subtracting) and does not reach normal level;
Increase the weight of: blood fat increases (subtracting) to the moderate level;
(2) moderate blood fat rising (or reduction)
Produce effects: blood fat increases (subtracting) and reaches normal level;
Effectively: blood fat increases (subtracting) to slight standard;
Invalid: blood fat increases (subtracting) and does not reach slight standard;
Increase the weight of: blood fat increases (subtracting) to the severe standard;
(3) severe blood fat rising (or reduction)
Produce effects: blood fat increases (subtracting) and reaches slight standard or normal level;
Effectively: blood fat increases (subtracting) and increases (subtracting) level to moderate standard, blood fat and do not reach the moderate standard, but absolute value descends---and TC and HDL-C2.6mMol/L:TG reach more than the 1.1mMol/L;
Invalid: blood fat increases (subtracting) and does not reach the moderate standard;
Increase the weight of: absolute value increases (TC and HDL-C2.6mMol/L:TG reach more than the 1.1mMol/L);
Six, therapeutic outcome:
1, the comparison of integration before and after two kinds of medicines are treated the hyperlipemia liver-kidney yin deficiency
Table 2
See before and after treatment group and the treatment of control group that the decline of disease integration has highly significant meaning (P＜0.01), the treatment group is compared P＞0.05 with matched group, and difference does not have the significance meaning.
2, the comparison of integration before and after two kinds of medicines are treated the hyperlipemia type of YIN-deficiency and interior-heat
Table 3
See before and after treatment group and the treatment of control group that the decline of disease integration has highly significant meaning (P＜0.01), the treatment group is compared P＞0.05 with matched group, and difference does not have the significance meaning.
3, the comparison of integration before and after two kinds of medicines are treated the hyperlipemia qi stagnation and blood stasis type
Table 4
See before and after treatment group and the treatment of control group that the decline of disease integration has highly significant meaning (P＜0.01), the treatment group is compared P＞0.05 with matched group, and difference does not have the significance meaning.
4, curative effect situation
4.1 two kinds of medicines to the curative effect of hyperlipemia liver-kidney yin deficiency relatively
Table 5
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate | R | t | p |
| The hepatic and renal YIN deficiency | A | 65 | 1 | 31 | 29 | 4 | 93.85 | 0.4672 | 16.2983 | ＜0.01 |
| B | 30 | 0 | 10 | 15 | 5 | 83.33 | 0.5710 |
To low sequence arrangement, the big weak curative effect of R value is so treatment group curative effect of medication is better than the matched group medicine to the curative effect grade by height.
4.2 two kinds of medicines to the curative effect of hyperlipidemia type of YIN-deficiency and interior-heat relatively
Table 6
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate | R | t | p | |
| Interior-heat caused by deficiency of YIN | A | 21 | 0 | 14 | 6 | 1 | 95.24 | 0.4351 | 9.6537 | ＜0.01 |
| B | 10 | 0 | 3 | 5 | 2 | 80 | 0.6355 |
To low sequence arrangement, the big weak curative effect of R value is so treatment group curative effect of medication is better than the matched group medicine to the curative effect grade by height.
4.3 two kinds of medicines to the curative effect of hyperlipemia qi stagnation and blood stasis type relatively
Table 7
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate | R | t | p | |
| Qi depression to blood stasis | A | 40 | 2 | 12 | 18 | 8 | 80 | 0.4738 | 12.6935 | ＜0.01 |
| B | 20 | 0 | 5 | 9 | 6 | 70 | 0.5525 |
To low sequence arrangement, the big weak curative effect of R value is so treatment group curative effect of medication is better than the matched group medicine to the curative effect grade by height.
Seven, toxic and side effects:
Two groups of patients all do not find obvious adverse reaction and toxic and side effects at viewing duration.
Model case
Example 1, old * *, male, 72 years old, live the Nanjing Road No. 40, because of lassitude loin and legs, vertigo and tinnitus, pharyngoxerosis, dysphoria with feverish sensation in the chest palms and soles, body of the tongue are red partially, tongue does not have Tianjin less, thready pulse heavy, tcm diagnosis: dizzy (hepatic and renal YIN deficiency disease) gives " bright damp capsule " each 4, every day 3 times, take medicine second when week of back, tell lassitude loin and legs, vertigo and tinnitus, dry mouth and throat and obviously alleviate, after the 3rd week of back of taking medicine, appeal to disease and disappear substantially, received satisfied curative effect.
Example 2, king * *, the male 40 years old, lives transfer joint transport company.Because of breast expands, rib is vexed, spirit depressing more than a year, go to a doctor on November 2nd, 1993, have a medical check-up: patient's dim complexion, costa sternales feeling of distension and oppression, purple dark, the deep-slow pulse in tongue limit, tcm diagnosis: costalgia (qi stagnation and blood stasis type), it is oral promptly to give " bright damp capsule ", every day 3 times, each 4, take medicine after the 3rd week, the patient tells spirit depressing and disappears, and complexion is glossy, and the costa sternales feeling of distension and oppression obviously alleviates.After taking medicine around the, check: all diseases disappear, and patient's spirit takes a turn for the better, and has received satisfactory effect.
Example 3, old * *, the women, 40 years old, live in the people and print factory, excuse is dizzy showed effect more than 2 years repeatedly, went to a doctor the fat of having a blood test when being admitted to hospital: serum total cholesterol 6.7mMol/L, serum levels of triglyceride 1.72mMol/L, HDL2 5mg/L on November 15th, 1993.Diagnosis: hyperlipemia, advise clothes " bright damp capsule " every day 3 times, each 4, around serveing on, check: dizzy disappearance, serum total cholesterol 4.68mMol/L, serum levels of triglyceride 1.10mMol/L, HDL2 5mg/L has reached satisfactory effect, and the patient requires to continue to take medicine.
Brief summary
Above clinical data discloses:
1, the bright damp capsule of medicine of the present invention has the effect of replenishing YIN and removing heat, nourishing the liver and kidney, benefiting QI for activating blood circulation, blood fat reducing, and the symptom of liver-kidney yin deficiency, type of YIN-deficiency and interior-heat, qi stagnation and blood stasis type hyperlipemia is all had significant improvement effect.
2, the bright damp capsule for treating hyperlipidemia patient of medicine of the present invention totally 246 examples, wherein 166 examples are organized in treatment, matched group 80 examples.Liver-kidney yin deficiency hyperlipemia 65 examples in 166 examples are organized in treatment, and effective percentage is 93.85%, type of YIN-deficiency and interior-heat hyperlipemia 21 examples, and effective percentage is 95.24%, qi stagnation and blood stasis type hyperlipemia 40 examples, effective percentage is 80%; Max EPA capsule treatment liver-kidney yin deficiency hyperlipemia 30 examples, effective percentage is 83.33%, type of YIN-deficiency and interior-heat hyperlipemia 10 examples, effective percentage is 80%, qi stagnation and blood stasis type hyperlipemia 20 examples, effective percentage is 70%.So curative effect of medication of the present invention is better than Max EPA capsule, thereby reaches final purpose of the present invention.
3, this product is safe and reliable, and 166 examples are not all found obvious adverse reaction and toxic and side effects at viewing duration.
Claims (10)
1, a kind of medicine for the treatment of hyperlipemia is characterized in that: making the raw materials of effective components component is by weight:
6～20 parts of Rhizoma Polygonatis; 6～20 parts of Radix Polygoni Multiflori Preparatas; 6～20 parts of Rhizoma Alismatis; 4～15 parts of Herb Gynostemmae Pentaphylli;
6～20 parts of Fructus Crataegis; 6～20 parts of Semen Cassiaes; 4～15 parts on Folium Nelumbinis; 4～15 parts of Flos Chrysanthemis.
2, a kind of medicine for the treatment of hyperlipemia is characterized in that: making the raw materials of effective components component is by weight:
12 parts of Rhizoma Polygonatis; 12 parts of Radix Polygoni Multiflori Preparatas; 12 parts of Rhizoma Alismatis; 8 parts of Herb Gynostemmae Pentaphylli;
12 parts of Fructus Crataegis; 12 parts of Semen Cassiaes; 8 parts on Folium Nelumbinis; 8 parts of Flos Chrysanthemis.
3, a kind of medicine production method of treatment hyperlipemia as claimed in claim 1 or 2 is characterized in that: produce capsule by the following method:
(1) gets 5/24 of Rhizoma Alismatis total amount, it is ground into fine powder, use 100-120 ℃ of high pressure steam sterilization 30～60 minutes, get intermediate products A with superfine communication technique;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% is made solvent, flood after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B;
(3) get Flos Chrysanthemi, Folium Nelumbinis, crataegus pin natifida var. Major and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C;
(4) B and C are mixed, drying is ground into fine powder, gets intermediate products dry extract D;
(5) get intermediate products A and D and appropriate amount of auxiliary materials mixing, granulate, drying, encapsulated, In Aluminium Foil Packing, packing gets the finished capsule product agent.
4, a kind of medicine production method of treatment hyperlipemia as claimed in claim 1 or 2 is characterized in that: produce soft capsule by the following method:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% is made solvent, flood after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B;
(2) get Flos Chrysanthemi, Folium Nelumbinis, crataegus pin natifida var. Major and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C;
(3) B and C are mixed, drying is ground into fine powder, promptly gets intermediate products dry extract D;
(4) get intermediate products dry extract D, vegetable oil, Cera Flava by making suspended matter H at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then suspended matter H fill is pressed into soft capsule, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out the soft capsule that gets product.
5, a kind of medicine production method of treatment hyperlipemia as claimed in claim 1 or 2 is characterized in that: produce slow releasing capsule by the following method:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% is made solvent, flood after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B;
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings decoctions twice together, decocted 1～2 hour at every turn, collecting decoction filters, and concentrate drying gets intermediate products fluid extract C;
(3) B and C are mixed, drying is ground into fine powder, gets intermediate products dry extract D;
(4) according to the total amount of intermediate products D, add 0.5～5% spermaceti or other blocker coating, make 2,4,6,8 hours slow-release pills respectively, every kind of piller is distinguished with different color and lusters, pack into behind the mix homogeneously in the capsulae vacuus, be packaged into box or be hot pressed into aluminium-plastic panel, obtain the finished product slow releasing capsule.
6, a kind of medicine production method of treatment hyperlipemia as claimed in claim 1 or 2 is characterized in that: produce drop pill by the following method:
(1) Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder are broken into coarse powder, according to the percolation under fluid extract and the extractum item, make solvent with the ethanol of 3～8 times of amount volume by volume concentrations 50%～80%, flood after 24 hours, slowly percolation is collected the liquid of filtering, reclaim ethanol, concentrate intermediate products fluid extract B;
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C;
(3) B and C are mixed, drying is ground into fine powder, promptly gets intermediate products dry extract D;
(4) with the polyethylene glycol 6000 heating and melting, get intermediate products dry extract D again and add, stir evenly, be transferred on the drop pill device, 86 ℃ of airtight insulations are made coolant with 10 ℃～15 ℃ liquid paraffin or other liquid, with the 50/component velocity system of dripping, drop pill gets product.
7, a kind of medicine production method of treatment hyperlipemia as claimed in claim 1 or 2 is characterized in that: produce tablet by the following method:
(1) get 5/24 of Rhizoma Alismatis total amount, it be ground into fine powder with superfine communication technique, with 100～120 ℃ of high pressure steam sterilizations 30～60 minutes, intermediate products A;
(2) get remaining Rhizoma Alismatis and Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% is made solvent, flood after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B;
(3) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C;
(4) B and C are mixed, drying is ground into fine powder, gets intermediate products dry extract D;
(5) get intermediate products A and D and appropriate amount of auxiliary materials mixing, granulate, drying, tabletting, sugar coating or film-coat, packing gets finished tablet.
8, a kind of medicine production method of treatment hyperlipemia as claimed in claim 1 or 2 is characterized in that: produce granule by the following method:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% is made solvent, flood after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate intermediate products fluid extract B;
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract C;
(3) B and C are mixed, drying is ground into fine powder, gets intermediate products dry extract D;
(4) get intermediate products D and appropriate amount of auxiliary materials mixing, granulate, drying, packing gets the finished particle agent.
9, a kind of medicine production method of treatment hyperlipemia as claimed in claim 1 or 2 is characterized in that: produce oral liquid by the following method:
(1) gets Rhizoma Alismatis, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Herb Gynostemmae Pentaphylli powder and be broken into coarse powder, according to the percolation under fluid extract and the extractum item, ethanol with 3～8 times of amount volume by volume concentrations 50%～80% is made solvent, flood after 24 hours, slow percolation, the collection liquid of filtering reclaims ethanol, concentrate the intermediate product stream extractum A;
(2) get Flos Chrysanthemi, Folium Nelumbinis, Fructus Crataegi and Semen Cassiae and add 3～8 times of water gagings together and decoct twice, decocted 1～2 hour at every turn, collecting decoction filters, concentrate intermediate products fluid extract B;
(3) get intermediate products A and B and an amount of syrup or Mel mixing, sterilization, fill gets the finished product oral liquid.
10, a kind of medicine production method of treatment hyperlipemia as claimed in claim 1 or 2 is characterized in that and can comprise said other dosage form on pill, unguentum and the pharmaceutics according to the method preparation of pharmacopeia or pharmacy of Chinese materia medica.
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| CN101720832B (en) * | 2008-12-02 | 2012-08-29 | 天津天狮生物发展有限公司 | Lipid-lowering tea and production process thereof |
| CN102068521B (en) * | 2011-01-13 | 2011-12-28 | 南京苏美瑞医药科技有限公司 | Traditional Chinese medicine composition for treating hyperlipidemia and preparation method and application thereof |
| CN102579628A (en) * | 2012-03-09 | 2012-07-18 | 施慧达药业集团(吉林)有限公司 | Chinese medicinal preparation for treating hyperlipidaemia and preparation method thereof |
| CN103432522A (en) * | 2013-08-26 | 2013-12-11 | 赵晶晶 | Chinese medicine formula for treating hyperlipidemia |
| CN104042684B (en) * | 2013-11-28 | 2016-08-17 | 天津天狮生物发展有限公司 | A kind of Chinese medicine composition containing Herb Gynostemmae Pentaphylli extract and preparation method |
| CN104688958A (en) * | 2015-03-18 | 2015-06-10 | 遵义陆圣康源科技开发有限责任公司 | Drug combination having function of losing weight |
| CN104857142A (en) * | 2015-05-27 | 2015-08-26 | 高振广 | Traditional Chinese medicine for treating hyperlipemia diseases and preparation method |
| CN105168764A (en) * | 2015-08-25 | 2015-12-23 | 郑慧峰 | Traditional Chinese medicine treating hyperlipidemia with symptoms of qi stagnation and blood stasis and preparation method |
| CN105311270A (en) * | 2015-11-30 | 2016-02-10 | 闻喜县红十字会心脑血管病专科医院 | Traditional Chinese medicine for treating hyperlipidemia and preparation method thereof |
| CN105999058B (en) * | 2016-05-31 | 2021-02-02 | 普洱市民族传统医药研究所 | Bidens bipinnata lipid-lowering tablet |
| CN108159301A (en) * | 2018-01-26 | 2018-06-15 | 安徽天马生物科技有限公司 | A kind of oral administration liquor for reducing blood fat and preparation method thereof |
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| 金脂泰胶囊质量标准研究 叶小强.中成药，第25卷第4期 2003 * |
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