CN1824763A - Fire internal organ nourishing wine and its preparation technology - Google Patents

Fire internal organ nourishing wine and its preparation technology Download PDF

Info

Publication number
CN1824763A
CN1824763A CN 200610045620 CN200610045620A CN1824763A CN 1824763 A CN1824763 A CN 1824763A CN 200610045620 CN200610045620 CN 200610045620 CN 200610045620 A CN200610045620 A CN 200610045620A CN 1824763 A CN1824763 A CN 1824763A
Authority
CN
China
Prior art keywords
wine
raw material
liquor
fruit
radix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN 200610045620
Other languages
Chinese (zh)
Other versions
CN100374538C (en
Inventor
刘景春
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CNB2006100456202A priority Critical patent/CN100374538C/en
Publication of CN1824763A publication Critical patent/CN1824763A/en
Application granted granted Critical
Publication of CN100374538C publication Critical patent/CN100374538C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a tonic liquor and its preparation process. It is made up by using 20 chinese medicinal materials of codonopsis root, cordyceps, American ginseng, ganoderma, astragalus root, lyceum berry, jujube and others and soaking them in an alcoholic liquor. Said invention also provides the concrete steps of its preparation method.

Description

Fire internal organ nourishing wine and preparation technology thereof
One, technical field: the present invention relates to a kind of wine and preparation technology, especially relate to a kind of adjusting human five internal organs, the tonic wine of its function of balance and its preparation technology.
Two, background technology: China is that the world grasps brewing technology and one of country of drinking the earliest.Our ancestors, in the process of creating the magnificent culture of Ancient Times in China, also accumulate abundant wine brewing experience and created colorful spirits culture, wine and medical science are in close relations, we can say that origin is permanent, the therapeutic action of wine is seen everywhere in the medical science works, and China's medical science works Huangdi's Internal Classics the earliest has " nutritious beverage,thick liquor and sweet liquor " specially piece of writing, and promptly the character to wine is described: " must be with rice; cook a meal; the rice person is intact with the rice firewood, rice firewood person heavily fortified point ... this gets the weather sum; relative superiority or inferiority suitable; so can cut down when obtaining to intact, thus can to heavily fortified point also." promptly to have put down in writing the wine sweet wine be that five cereals form through fermentation after boiling again.
The hot temperature of the nature and flavor sweetness and bitterness of wine is gone into the heart, liver, lung, stomach warp.Its effect, " wine spectrum " meaning " the speech breast of wine also, so the body that softens hold up always also "; The supplement to the Herbal meaning " promoting blood circulation, thick stomach, profit skin, the moisture that looses, the sorrow that disappears is angry, declaration is freely anticipated "." not Lu " calls its " row medicine gesture is killed hundred evil poison gases ".According to its prescription and brew method different, drinking utensils has temperature three-way meridian, expelling wind and cold, activates blood circulation and disperses blood clots, subduing swelling and relieving pain, strengthen muscles and bones, effect such as benefiting vital QI and blood.Also put down in writing in the traditional medicine works and added the multiple tonic wine that medicinal raw material makes, but these tonic wines can only be nourished at specific symptoms such as underactivity, and can't play simultaneously and qi and blood after taking, support internal organs, transfer taste, strong spirit, please color, separate overstrain, mend multiple effects such as all void, also do not have such tonic wine product on the market.And traditional tonic wine also exists need to adopt high wine to make the wine base and prepares, and makes the out of use shortcoming of part patient.
Three, summary of the invention:
1, goal of the invention: the invention provides fire internal organ nourishing wine and preparation technology thereof, its objective is that solving traditional tonic wine only nourishes at specific underactivity, can not play simultaneously and qi and blood, support internal organs, transfer taste, strong spirit, please color, separate overstrain, mend multiple effects such as all void, and the most alcoholic strengths of traditional tonic wine are higher, the problem that aspects such as the part patient can not use are existed.
2, technical scheme: the present invention is achieved through the following technical solutions:
A kind of fire internal organ nourishing wine is characterized in that: this tonic wine is that the medicinal raw material that adds following prescription in per 5～10 kilograms of wine makes: Radix Codonopsis 15～50g, Cordyceps sinensis 10～30g, Glossy Privet Fruit 15～50g, Radix Panacis Quinquefolii 10～50g, glossy ganoderma 15～60g, the tuber of dwarf lilyturf 10～30g, radix polygonati officinalis 15～30g, Radix Astragali Preparata 15～50g, hawthorn 10～30g, baked polygonum capitatum 15～50g, cultivated land 15～50g, wolfberry fruit 30～250g, Fructus Mori 30～300g, longan aril 70～300g, semen juglandis 15～100g, shizandra berry 10～50g, skunk bush 10～50g, date 20～100g, Formica fusca 6～50g, Herba Cistanches 10～100g.
It is a kind of in 32 °～60 ° liquor or the rice wine below 28 ° and fruit wine, the grape wine that described wine is selected alcoholic strength for use.
A kind of preparation technology of fire internal organ nourishing wine is characterized in that: it is undertaken by following particular step:
A. get each medicinal raw material by the described prescription of claim 1;
B. each medicinal raw material is carried out pre-treatment;
C. the soup that step b is obtained after to the medicinal raw material pre-treatment mixes and blends;
D. mixing is blent and promptly get tonic wine of the present invention after back soup and wine adopt infuse method, brew method or percolation to handle.
Above-mentioned steps b carries out pre-treatment to medicinal raw material: Cordyceps sinensis and Radix Panacis Quinquefolii → obtain after soaking in Chinese liquor → heat treated → clarification respectively Cordyceps sinensis liquid and american ginseng liquid; Hawthorn, wolfberry fruit, shizandra berry, date, walnut → processing are after obtain soup after soaking in Chinese liquor → clarification; Formica fusca and other Chinese medicinal materials → through after selected, the removal of impurity → soak, obtain soup after lixiviate → filtration → clarification; Four kinds of soups of above-mentioned gained are mixed to blend promptly get medicinal raw material pre-treatment soup.
Above-mentioned pre-treatment to each medicinal raw material is: the Radix Astragali is processed with honey, and 1.5 jin of sweet big guns of per 10 jin of usefulness are processed, and stirs evenly; Cultivated land adopts the dried rhizome of rehmannia to stir with wine, and 10 jin add 1 jin of yellow rice wine and stir; Baked polygonum capitatum adds yellow rice wine with Radix Polygoni Multiflori and stirs, and 10 jin add 1 jin of yellow rice wine; The preparation of Radix Panacis Quinquefolii extractive juice: select for use total saponin content greater than 8% high-quality Radix Panacis Quinquefolii, after cleaning removal impurity, be broken into small-particle with pulverizer less than 5mm, to increase its surface-area, improve leaching efficiency, ginseng granules after the fragmentation is quantitatively dropped in the alcohol reflux lixiviate jar, the concentration that adds 10 times of weight is 85% ethanolic soln, under 45 ℃ temperature, soaked 72 hours, emit pure liquid filtration then and obtain filtrate I, repeat again to soak once, filter and obtain filtrate II, the fresh ethanol solution that adds 8 times of weight in the ginseng slag after twice immersion filtration was once more refluxed 2.5 hours, temperature≤80 ℃, repetitive operation twice is collected respectively and is obtained filtrate II I and IV, above-mentioned 4 kinds of filtrates of collecting are merged, and underpressure distillation recovery ethanol, the nothing alcohol vat liquor of gained carries out vacuum concentration under 62 ℃ condition, be concentrated into 1/2 volume, in gained genseng vat liquor, add 6% cycloheptaamylose, utilize dextrin the in addition embedding and alleviate its bitter taste of ginsenoside composition to minimum degree; Matrimony vine is handled: remove impurity, cleaning, wolfberry fruit is steeped the cell tissue of 2h with softening matrimony vine with 40 ℃ water logging, carry out crushing and beating with hollander then, the gained slurries add the lixiviate 3 hours of purifying waste water under 70～80 ℃ temperature of 10 times of weight, remove by filter residue, gained matrimony vine juice is through vacuum concentration to 1/2 volume, and the cooling back is standby; The pre-treatment of walnut kernel: select completely filled fruit, no worm, do not have the walnut kernel that goes mouldy, remove the kind skin of walnut kernel, NaOH solution with 2.0 ℃, be heated to 95 ℃, walnut kernel immersed in the solution soaked about 1 minute, take out and remove kernel kind skin and remaining NaOH with flushing with clean water, the walnut kernel after the peeling was with 35～40 ℃ warm water soaking 1.5-2 hour, the walnut kernel histocyte is fully expanded moisten, soften, improve the protein leaching yield; The preparation of haw raw material: select lovely luster for use, fully ripe, full, the Fructus Crataegi of no disease and pest, remove impurity, clean up, to put in order fruit with discaling roll formula pulverizer or manual type and be ground into 4～5 fritters, then with in the purifying waste water of 2 times of weight of hawthorn fruit piece input, feeding is steam heated to 85～95 ℃, and be incubated 30 minutes and soften processing, making the hawthorn histocyte fully expand to moisten softens, improve the leaching yield of active substance, hawthorn fruit piece after softening and softening water are sent into hollander together and are carried out crushing and beating, the gained slurries carry out miniaturization by colloidal mill again to be handled, refinement degree≤5 μ m, and gained haw pulp Normal juice cooling back is standby; The preparation of red date, Radix Astragali vat liquor: select for use lovely luster, fully ripe, do not have go mouldy, the date of no insect pest, the Radix Astragali be raw material, after removing impurity, clean up with clear water, add purifying waste water of 3 times of weight then, put into steam cooker, feed and be steam heated to 90～95 ℃, add a cover insulation 30 minutes, after the filtration vat liquor II, twice vat liquor merged and be cooled to after the room temperature standby; Formica fusca: the select fine seed strains ant, require the polyrhachis of drying, inclusion-free, free from extraneous odour, no pesticidal contamination all, adopt cold-maceration, Formica fusca and Chinese medicinal materials all soaked 15～20 days at normal temperatures with alcohol, and lixiviate is filtered, recovered alcohol is drawn supernatant liquor then, and it is standby to mix clarification; Walnut: select for use the kernel complete, clean, that free from insect pests is gone mouldy to be pale yellow to amber, the washing walnut of kernel content 〉=55% or common walnut, iron walnut are raw material, adopt the alcohol extracting technology of fat melting, fully lixiviate goes out its effective nutritive ingredient, in allocation process, call in an amount of Fructus Vitis viniferae wine base and natural medicinal flavours; Juice is got in the longan aril fragmentation: after peeling, the stoning, the method for using Mechanical Crushing is pressed extracting juice with expeller again with pulp crushing, for preventing the oxidation stain of microbiological contamination and fruit juice, adds the potassium metabisulfite of 120mg/kg at pulp.
The preparation of above-mentioned Cordyceps sinensis liquid: get the bright product of Cordyceps sinensis, add end wine in 1: 300 ratio, the room temperature lixiviate is 7～10 days in the lixiviate jar, filter, filter residue adds end wine in 1: 200 ratio, lixiviate 5～7 days is filtered, and merges the twice golden yellow extremely pale brown look filtrate of gained and promptly gets Cordyceps sinensis liquid; The preparation of lucidum liquid: the glossy ganoderma dry product is broken for the fritter about 1cm, adds end wine in 1: 200 ratio, and lixiviate is 15 days in the lixiviate jar, filters, and filter residue adds steeping in wine by 1: 100 ratio and carries 10 days, and filtration merges twice filtrate promptly; The preparation of herb liquid: in 5: 3: 3: 6 ratio takes by weighing wolfberry fruit, Radix Codonopsis, Glossy Privet Fruit, the mixing tuber of dwarf lilyturf respectively, add softening water in 1: 30 ratio, put in the lixiviate jar, in 55～65 ℃ of insulation lixiviates 10～16 hours, filter, filter residue added softening water in 1: 10 ratio, in 75～85 ℃ of insulation lixiviates 4～6 hours, filter, merging filtrate promptly; Above-mentioned gained soup is mixed, blends: in 1: 1: 1: 1 ratio with Cordyceps sinensis liquid, lucidum liquid, herb liquid, liquid glucose in mixing tank thorough mixing, convert equal.
Described infuse method adopts cold-maceration: after the consumption medicinal raw material pre-treatment of will filling a prescription, in the input container, be blended into high quality liquor or yellow rice wine by ratio, sealing is soaked, the abundant stripping of the effective constituent in the medicine was stored in often jolting or stir medicine 1～180 day between soak period, the property of medicine and alcoholic strength fully merge, and wine juice is leached promptly.
Described brew method, with the formula ratio medicinal raw material clean drain after, through pre-treatment shooting soup, to mix thoroughly with the steamed sticky rice meal behind the medical filtration, treat that its back that cools off adds distiller's yeast, or after medicine smashed to pieces, direct and glutinous rice boils together, in container, make its fermentation 1～180 day, to wine flavour when sweet, promptly by making the sweet wine method.
Described percolation be will prescription medicinal raw material be cut into fragment or smash into thick end, with after the liquor moistening expansion, in the percolator of packing into, be blended into liquor and carry out diacolation, the composition of medicine is diffused in the diacolation process in the wine promptly.
3, advantage and effect: by the enforcement of technical solution of the present invention, can solve traditional tonic wine well only nourishes at specific underactivity, can not play simultaneously and qi and blood, support internal organs, transfer taste, strong spirit, please color, separate overstrain, mend multiple effects such as all void, and traditional tonic wine adopts the higher wine of alcoholic strength to cook the wine base more, the problem that aspects such as the part patient can not use are existed.Fire internal organ nourishing wine of the present invention is that contriver Liaoning China traditional methods to keep in good health rehabilitation research president Liu Jingchun of institute is on the basis of tonic wine handed down from one's ancestors, through over thousands of kind of herbal medicine conscientiously screened, its compatibility plays the effect of mutual reinforcement, and adopt specific prepared, its function has and qi and blood simultaneously, support internal organs, transfer taste, strong spirit, please color, separate overstrain, mend the effect of all void, it is soft to make the tonic wine mouthfeel, local flavor is pure, is rich in the multiple nutrients health-care components, has qi-restoratives and nourishes blood, nourshing Yin and drynsessmoistening prescription, profit face skin makeup and moistening the lung and relieve the cough, antitumor, antifatigue, effects such as radioprotective, be applicable to that body void is weak, lean and haggard, people such as the five internal organs consumptive disease drink, and can play the effect of enhance immunity power and skin makeup.Owing to can adopt liquor, yellow rice wine, grape wine, fruit wine or the beer of high or low degree to make the wine base, drink so be fit to majority.
Four, embodiment:
Fire internal organ nourishing wine of the present invention and preparation technology thereof, mainly be to select 32～60 ° liquor for use, grape wine, a kind of in the rice wine below 28 °, add the Chinese medicinal materials raw material of following prescription in per 5～10 kilograms of wine of selecting for use, its prescription is: Radix Codonopsis 15～50g, Cordyceps sinensis 10～30g, Glossy Privet Fruit 15～50g, Radix Panacis Quinquefolii 10～50g, glossy ganoderma 15～60g, the tuber of dwarf lilyturf 10～30g, radix polygonati officinalis 15～30g, Radix Astragali Preparata 15～50g, hawthorn 10～30g, baked polygonum capitatum 15～50g, cultivated land 15～50g, wolfberry fruit 30～250g, Fructus Mori 30～300g, longan aril 70～300g, semen juglandis 15～100g, shizandra berry 10～50g, skunk bush 10～50g, date 20～100g, Formica fusca 6～50g, Herba Cistanches 10～100g.
The preparation technology of tonic wine of the present invention is undertaken by following particular step:
A. get each medicinal raw material by above-mentioned prescription, will clean behind each medicinal raw material removal impurity;
B. each medicinal raw material is carried out pre-treatment;
C. the soup that step b is obtained after to the medicinal raw material pre-treatment mixes and blends;
D. mixing is blent and promptly get tonic wine of the present invention after back soup and wine adopt infuse method, brew method or percolation to handle.
Pre-treatment to each medicinal raw material among the above-mentioned steps b is: the Radix Astragali is processed with honey, and 1.5 jin of sweet big guns of per 10 jin of usefulness are processed, and are advisable to stir evenly; Cultivated land adopts the dried rhizome of rehmannia to stir with wine, and 10 jin add 1 jin of yellow rice wine and stir; Baked polygonum capitatum system adds yellow rice wine with Radix Polygoni Multiflori and stirs, and 10 jin add 1 jin of yellow rice wine.
The preparation technology of main Chinese medicinal materials raw material in the above-mentioned prescription:
Medicinal material is handled: be equipped with medicine according to fire internal organ nourishing wine prescription of the present invention.At first with the medicinal material removal of contamination, or dry with silt or the sordid impurity flush away that clear water will be attached to the medicinal material surface, be processed into the tablet or the particle of different big or small thickness then according to the structure situation of medicinal material tissue, general requirement is that thick rhizome, rattan and wooden class should be cut into tablet, skin and Ye Qiesi, herb segment, fruit such as smash at traditional processing method, also can study with comminuting method and be beneficial to extract better effective constituent in the medicinal material.
1. the preparation of Radix Panacis Quinquefolii extractive juice: select for use total saponin content greater than 8% high-quality Radix Panacis Quinquefolii, clean impurity such as removing the adherent earth of institute after, be broken into small-particle with pulverizer less than 5mm, to increase its surface-area, improve leaching efficiency; Ginseng granules after the fragmentation quantitatively drops in the alcohol reflux lixiviate jar, and the concentration that adds 10 times of weight is 85% ethanolic soln, soaks 72h under 45 ℃ temperature, emits pure liquid filtration then and obtains filtrate I, repeats to soak once again, filters and obtains filtrate II.To add the fresh ethanol solution backflow 2.5h of 8 times of weight in the ginseng slag after twice immersion filtration once more, controlled temperature is no more than 80 ℃, and repetitive operation twice is collected respectively and obtained filtrate II I and IV.Above-mentioned 4 kinds of filtrates of collecting are merged, and underpressure distillation reclaims ethanol, the nothing alcohol vat liquor of gained carries out vacuum concentration under 62 ℃ condition, when being concentrated into 1/2 volume till.Do not influence its mouthfeel (the little hardship of ginsenoside) and local flavor in order to make after adding the genseng vat liquor, this technology takes to add 6% cycloheptaamylose in the genseng vat liquor, utilizes dextrin with the in addition embedding and alleviate its bitter taste to minimum degree of ginsenoside composition.
2. matrimony vine: at first will remove the branches and leaves that are mingled with etc., then wash impurity such as adherent earth of institute and worm's ovum on it off with clear water; The wolfberry fruit that cleans up steeps the cell tissue of 2h with softening matrimony vine with 40 ℃ water logging, carry out crushing and beating with hollander then, the gained slurries add the lixiviate 3h under 70～80 ℃ temperature that purifies waste water of 10 times of weight, remove by filter residue, gained matrimony vine juice is through vacuum concentration to 1/2 volume, and the cooling back is standby.
3. the pre-treatment of walnut kernel: the raw material walnut is isolated walnut kernel after broken shell, chooses completely filled fruit wherein, no worm, does not have the kernel that goes mouldy, and will remove the kind skin of walnut kernel then, otherwise can influence the local flavor and the color and luster of wine.The NaOH solution that this process using is 2.0 ℃ is heated to 95 ℃, walnut kernel is soaked in people's solution soaked about 1 minute, pulls out immediately, removes kernel kind skin and remaining NaOH with a large amount of flushing with clean water; Walnut kernel after the peeling is with 35～40 ℃ warm water soaking 1.5～2 hours, is in order to make the walnut kernel histocyte profit, softening that fully expands, to improve the protein leaching yield, making the product color knot white and fine and smooth like this.
4. date: nutritive value is quite high, contains 13 seed amino acids, and contained carbohydrate is mainly his oligose of glucose, fructose, sucrose and tool, and every 100g dry fruit platform vitamins C reaches 2g.Contain CAMP, sterols biologically active substance in addition, have calm sleeping, step-down, antianaphylaxis, protection liver, muscle strength reinforcing, effect such as anti-oxidant, antitumor.It has effects such as vessel softening, hypotensive, reducing blood-fat, prevention of arterial harden, improve a poor appetite, promoting digestion, and the acetic acid volatile component of fruit juice fermentation is few simultaneously, and taste is softer, and pungency is little.Therefore the various drinks of date are hypertension, hyperlipidemia, cardiovascular and cerebrovascular patient ideal health promoting beverage.
5. the preparation of haw raw material: the Fructus Crataegi of selecting lovely luster, fully ripe, full, no disease and pest for use, impurity such as the branch of removing wherein to be mingled with, leaf, carpopodium, native stone, clean up with clear water, to put in order fruit with discaling roll formula pulverizer or manual type and be ground into 4～5 fritters, then with in the purifying waste water of 2 times of weight of hawthorn fruit piece input, feeding is steam heated to 85～95 ℃, and be incubated 30 minutes and soften processing, profit is softening so that the hawthorn histocyte fully expands, and improves the leaching yield of active substance; Hawthorn fruit piece after softening and the softening water hollander of making a gift to someone together carries out crushing and beating, and the gained slurries are delivered to colloidal mill by underflow pump and carried out miniaturization and handle, and degree of refinement should be advisable below 5 μ m, and gained haw pulp Normal juice cooling back is standby.
6. the preparation of red date, Radix Astragali vat liquor: select for use lovely luster, fully ripe, do not have go mouldy, the date of no insect pest, the Radix Astragali be raw material, after the hand picking removal of impurities, clean up with clear water, add purifying waste water of 3 times of weight then, put into steam cooker, feed and be steam heated to 90～95 ℃, add a cover insulation 30 minutes, after the filtration vat liquor II, twice vat liquor merged and be cooled to after the room temperature standby.
7. Formica fusca: select fine seed strains ant (polyrhachis) all requires drying, inclusion-free, free from extraneous odour, no pesticidal contamination.After testing, protein content is more than 40%, and aminoacids content is more than 17 kinds.
Extract ant liquid: abundanter at the high characteristics of Formica fusca protein content and amino acid, VITAMIN, mineral substance, adopt cold-maceration in process of production, Formica fusca and Chinese medicinal materials all soak 15～20d at normal temperatures with alcohol, lixiviate, filter, recovered alcohol is drawn supernatant liquor then, and it is standby to mix clarification.Formica fusca liquid is blent usefulness.
8. walnut: should adopt the washing walnut.Common walnut and iron walnut all can, fruit requires complete, clean, free from insect pests mildew phenomena, does not carry any impurity secretly.It is pale yellow to amber that kernel is, and the kernel content requirement is more than 55.
Have low, protein of sugar and the high characteristics of lipid content of containing at the walnut nut.Adopt the alcohol extracting technology of fat melting aborning, fully lixiviate goes out its effective nutritive ingredient, in allocation process, calls in an amount of Fructus Vitis viniferae wine base and natural medicinal flavours, makes its wine body more apparent abundant, and sense of taste is mellow, and delicate fragrance is pleasant, and tool walnut wine peculiar flavour.
9. juice is got in the longan aril fragmentation: after lichee peeling, the stoning, the method for using Mechanical Crushing is pressed extracting juice with expeller again with pulp crushing.For preventing the oxidation stain of microbiological contamination and fruit juice, can add the potassium metabisulfite of 120mg/kg at pulp.
10. the deodorization of alcohol is handled: 95% alcohol is diluted to 32%, adds 0.01% potassium permanganate oxidation earlier and handle after 8 hours, add bitter taste and foreign odor flavor in 0.03% the charcoal absorption wine again.
11. the preparation of Cordyceps sinensis liquid: take by weighing the bright product of Cordyceps sinensis, add the end wine that has good quality in 1: 300 ratio, the room temperature lixiviate is 7-10 days in the lixiviate jar, filters; Filter residue adds end wine in 1: 200 ratio, and lixiviate 5～7 days is filtered, and merging the twice golden yellow extremely pale brown look filtrate of gained is Chinese caterpillar fungus liquid.
12. the preparation of lucidum liquid: the glossy ganoderma dry product is broken for the fritter about 1cm, adds end wine in 1: 200 ratio, and lixiviate is 15 days in the lixiviate jar, filters; Filter residue adds steeping in wine in 1: 100 ratio and carries 10 days, filters, and merges filtrate twice.
13. the preparation of herb liquid: in 5: 3: 3: 6 ratio takes by weighing wolfberry fruit, Radix Codonopsis, Glossy Privet Fruit, the tuber of dwarf lilyturf respectively mixes in right amount, adds softening water in 1: 30 ratio, puts in the lixiviate jar, in 55～65 ℃ of insulation lixiviates 10～16 hours, filters; Filter residue adds softening water in 1: 10 ratio, and is little in 75～85 ℃ of insulation lixiviates 4～6, filters merging filtrate.
14. mix, blend: in 1: 1: 1: 1 ratio made its sugar, wine, acid reach proper ratio Cordyceps sinensis liquid, lucidum liquid, herb liquid, liquid glucose thorough mixing in mixing tank.
15. acid adjustment: in mixing tank, add an amount of citric acid, to proofread and correct local flavor according to basic wine sensory evaluation result.
16. ageing: with the basic wine after the acid adjustment, be sealed in natural 2～4 weeks of ageing in the basin, with the assorted flavor that volatilizees, form some aromatising flavour materials, make the mellow silk floss of wine body gentle, graceful fine and smooth, all flavors are coordinated, unique style.
Wine 17. filter, sterilize after the ageing needs to filter through diatomite filter or flame filter press, further separate fine solid shape suspended substance.
18. the deodorization of alcohol is handled: 95% alcohol is diluted to 32%, adds 0.01% potassium permanganate oxidation earlier and handle after 8 hours, add bitter taste and foreign odor flavor in 0.03% the charcoal absorption wine again.
Fire internal organ nourishing wine preparation technology flow process of the present invention is as follows:
Cordyceps sinensis → cleaning → 32 degree soaking in Chinese liquor → heat treated → clarification → soups;
Radix Panacis Quinquefolii → cleaning → 32 degree soaking in Chinese liquor → heat treated → clarification → soups;
Hawthorn, wolfberry fruit, shizandra berry, date, walnut → processing → 32 degree soaking in Chinese liquor → clarification → soups;
Formica fusca and other Chinese medicinal materialss → selected, the removal of impurity → immersion, lixiviate → filtration → clarification → soup;
With four kinds of soups of above-mentioned gained → through seasoning → quality inspection → clarification → filtration → can → finished product.
Cordyceps sinensis → 32 degree liquor lixiviate → Chinese caterpillar fungus liquid;
Glossy ganoderma → 32 degree liquor lixiviate → lucidum liquids;
Chinese medicinal materialss such as wolfberry fruit → soft water lixiviate → herb liquid;
Above-mentioned Chinese caterpillar fungus liquid, lucidum liquid and herb liquid → mix → blend → acid adjustment is handled.
Hawthorn selects → cleans → broken → softening → beater colloid mill fine grinding → hawthorn Normal juice;
Skunk bush → select materials → clean → remove the peel → stripping and slicing → softening → system juice;
Mulberry chess piece → cleaning → pulverizing → hot water lixiviate → alcohol extracting;
With three kinds of extracting solutions of gained after the above-mentioned processing through mixing, blending → allocate → outgas → homogeneous → heating → can envelope → sterilization → cool off → get product.
The function of fire internal organ nourishing wine of the present invention is the yang blood and qi of help internal organs, to recover and to improve the function of internal organs, builds up health, and improves the disease-resistant ability of human body.The disease that is used for human body yang blood and qi deficiency is anti-ageing, antitumor etc.Be applicable to weakness due to chronic disease, various illnesss such as body fluid deficiency for the internal organs essence and blood, hypofunction.
Embodiment 1:
The present invention adds the Chinese medicinal materials raw material of following prescription in 32 ° of liquor of every 5Kg: Radix Codonopsis 15g, Cordyceps sinensis 10g, Glossy Privet Fruit 15g, Radix Panacis Quinquefolii 10g, glossy ganoderma 15g, the tuber of dwarf lilyturf 10g, radix polygonati officinalis 15～30g, Radix Astragali Preparata 15g, hawthorn 10g, baked polygonum capitatum 15g, cultivated land 15g, wolfberry fruit 30g, Fructus Mori 30g, longan aril 70g, semen juglandis 15g, shizandra berry 10g, skunk bush 10g, date 20g, Formica fusca 6g, Herba Cistanches 10g.
The preparation technology of tonic wine of the present invention is undertaken by following particular step:
A. get each medicinal raw material by above-mentioned prescription, will clean behind each medicinal raw material removal impurity;
B. each medicinal raw material is carried out pre-treatment, undertaken by above-mentioned method according to the characteristics of each medicinal material;
C. the soup that step b is obtained after to the medicinal raw material pre-treatment mixes and blends;
D. mixing is blent and promptly get tonic wine of the present invention after back soup and wine adopt the infuse method to handle.
The medicinal liquor that adopts the infuse method to make can be applicable to various diseases, oral administration and externally all can, the infuse method is divided cold-maceration and hot dipping method again.Cold-maceration: according to state of an illness needs, after required medicine or food allocated by the prescription consumption, material selected washing is clean to drain, section or pulverize after, put in the vessel that have been prepared in advance, be blended into high quality liquor or yellow rice wine by ratio, sealing is soaked.For some time is stored in often jolting or stir medicine between soak period, or three or five days, or the several months, the time person of immersion is also arranged, the in general fresh medicine time can suitably lack, having certain toxic medicine or dry product soak time can grow, weak point person's two weeks, the elder can reach more than half a year, treated the abundant stripping of effective constituent in the medicine, when the property of medicine and alcoholic strength fully merge, wine juice is leached, and every day, the clothes several was obeyed an amount of at every turn.
Embodiment 2:
The present invention adds the Chinese medicinal materials raw material of following prescription in 28 ° of yellow rice wine of every 8Kg: Radix Codonopsis 33g, Cordyceps sinensis 20g, Glossy Privet Fruit 32g, Radix Panacis Quinquefolii 30g, glossy ganoderma 38g, the tuber of dwarf lilyturf 120g, radix polygonati officinalis 23g, Radix Astragali Preparata 33g, hawthorn 20g, baked polygonum capitatum 32g, cultivated land 33g, wolfberry fruit 140g, Fructus Mori 170g, longan aril 185g, semen juglandis 58g, shizandra berry 30g, skunk bush 30g, date 60g, Formica fusca 28g, Herba Cistanches 55g.
The preparation technology of tonic wine of the present invention is undertaken by following particular step:
A. get each medicinal raw material by above-mentioned prescription, will clean behind each medicinal raw material removal impurity;
B. each medicinal raw material is carried out pre-treatment, undertaken by above-mentioned method according to the characteristics of each medicinal material;
C. the soup that step b is obtained after to the medicinal raw material pre-treatment mixes and blends;
D. mixing is blent and promptly get tonic wine of the present invention after back soup and wine adopt the brew method to handle.
Described brew method is for getting fresh as required in proportion or the exsiccant medicine, with medicine clean drain after, bright person can smash and get juice, after dried person can pulverize medicine, adding decocting takes concoction, concoction is filtered the back mix thoroughly, treat that its back that cools off adds distiller's yeast, after sugariness help medicine also can be smashed medicine to pieces with the steamed sticky rice meal, direct and glutinous rice boils together, allow its fermentation with putting in the vessel as making the sweet wine method, when sweet, can take out and drink to wine flavour.The existing wine sweet wine of the made medicinal liquor of this method fragrant and sweet has pharmaceutical cpd again and possesses therapeutic action, wine assisting drug, and current whole body, not high because of its alcoholic strength again so its curative effect is reliable, and the effect of tool benefiting vital QI and blood, extensively suitable all kinds of personnel take.
Embodiment 3:
The present invention adds the Chinese medicinal materials raw material of following prescription in 50 ° of liquor of every 10Kg: Radix Codonopsis 50g, Cordyceps sinensis 30g, Glossy Privet Fruit 50g, Radix Panacis Quinquefolii 50g, glossy ganoderma 60g, the tuber of dwarf lilyturf 30g, radix polygonati officinalis 30g, Radix Astragali Preparata 50g, hawthorn 30g, baked polygonum capitatum 50g, cultivated land 50g, wolfberry fruit 250g, Fructus Mori 300g, longan aril 300g, semen juglandis 100g, shizandra berry 50g, skunk bush 50g, date 100g, Formica fusca 50g, Herba Cistanches 100g.
The preparation technology of tonic wine of the present invention is undertaken by following particular step:
A. get each medicinal raw material by above-mentioned prescription, will clean behind each medicinal raw material removal impurity;
B. each medicinal raw material is carried out pre-treatment, undertaken by above-mentioned method according to the characteristics of each medicinal material;
C. the soup that step b is obtained after to the medicinal raw material pre-treatment mixes and blends;
D. mixing is blent and promptly get tonic wine of the present invention after back soup and wine adopt percolation to handle.
Described percolation mainly is that medicine is cut into fragment or smashes into thick end, after the moistening expansion of liquor, in the dress people percolator, be blended into liquor and carry out diacolation, the composition of medicine is diffused in the wine in the diacolation process, this method does not need to soak and fermentation, is suitable for pharmacy producer and produces medicinal liquor in enormous quantities and be not suitable for family's preparation.
(1). prescription drug pharmacological action of the present invention is analyzed as follows:
(1), Radix Codonopsis is the dry root of campanulaceae plant Radix Codonopsis Codonopsis pilosula (Franch.) Nannf. plain flower Radix Codonopsis Codonopsispilosul Nannf.var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen Codonopsis tangshen Oliy.Invigorating the spleen and replenishing QI, invigorating the spleen benefit lung.Be used for that the spleen deficiency syndrome of the lung is weak, the palpitaition of breathing hard, anorexia and loose stool, void are breathed with cough disease such as cough, interior heat is quenched one's thirst.
1. enhancing body stress ability: the survival time that Radix Codonopsis can significant prolongation mouse normobaric hypoxia, prolong on different third kidney survival time of histanoxia mouse due to element, prussiate, the Sodium Nitrite, and can prolong the survival time of ligation bilateral carotid cerebral anoxia mouse;
2. enhancing body immunologic function; Radix Codonopsis can obviously strengthen the phagocytic function of mouse monokaryon macrophage system, improves peritoneal macrophage chicken red blood cell phagocytic rate, increases phagocytic index.Also can the antagonism hydrocortisone, ring phosphorus phenol amine is to the restraining effect of scavenger cell.Radix Codonopsis polysaccharide can improve the thymocyte E garland rate of formation of normal mouse and immunosuppressed mice; The mouse delayed type hypersensitivity that dinitrochlorobenzene is brought out is restraining effect, and immunosuppressed mice is then had restitution;
3. delaying senility function; To feed silkworm behind the 20% Radix Codonopsis decocting liquid immersion mulberry leaf, can prolong the larval stage of silkworm, full lifetime, and put on weight.In vitro tests shows: superoxide-dismutase (SOD) activity of human blood can improve in Radix Codonopsis extract, increases the ability of removing free radical, and the prompting Radix Codonopsis has certain delaying senility function.
(2), Cordyceps sinensis is that section ergot fungus cordyceps sinensis bacterium Cordycepssinensis (Berk.) Sace. colonizes in stroma and the larva cadaveric complex on the bat moth insect larvae.The early summer stroma is unearthed, does not take when spore is dispersed, and shines to 6 seventy percent and does, and removes quasi-fibrous dirt settling and impurity, dries or cryodrying.But the help kidney, hemostasis and phlegm.Be used for that chronic cough is breathed heavily, diseases such as labor is coughed spitting of blood, impotence and seminal emission, soreness of waist and knee joint.
1. to the effect of liver: cordyceps sinensis polysaccharide liposome (CPL) aqua is to CCl 4And liver injury all has provide protection due to the D-Gal;
2. antineoplastic action: Cordyceps Polysaccharide and aqueous extract are to sarcoma (S 180), isolated culture knurl spider such as Lewis lung cancer, mammary cancer (MA-737), laryngocarcinoma all has significant inhibitory effect.The Chinese caterpillar fungus aqueous extract primary tumor of mouse subcutaneous transplanting Lewis lung cancer is produced and the transfer of spontaneous lung obvious suppression effect, tumour inhibiting rate are all arranged is 67%.Cordyceps mycelium and anticarcinogen combined utilization can strengthen the antitumour activity that encircles phosphorus phenol amine, the thin basic fat cry of certain animals of 6-, vincristine(VCR);
3. to the effect of kidney: 1. to the effect of medicine renal toxicity damage: drug-induced renal toxicity damage has tangible preventive and therapeutic effect to Chinese caterpillar fungus to aminosugar back of the body class.2. to the provide protection of ischemia injury of the kidney: Cordyceps sinensis has the reduction effect to rat blood serum and renal cortex lipid peroxide.
(3), Glossy Privet Fruit is the dry mature fruit of the Ligustgum cucidnm.Ait. of Oleaceae plant Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty.Can be nourishing liver and kidney, the crow that makes eye bright sends out.Be used for diseases such as dizziness and tinnitus, lassitude loin and legs, early whitening of beard and hair, order be secretly not clear.
1. to immune influence: the Oleanolic Acid in the Glossy Privet Fruit has the lymphopoiesis of promotion and animal macrophage phagocytic function, and the effect of delayed hypersensitive reaction has synergy with IL-2.Immunity has enhancement to Fructus Ligustri Lucidi polysaccharide to non-specific cell, and the cellular immunization of immunosuppressive condition mouse is had enhancement;
2. hypoglycemic, reducing blood-fat: experimentation on animals shows: the Glossy Privet Fruit element, the Oleanolic Acid that extract in Glossy Privet Fruit decoction, the Glossy Privet Fruit all have good hypoglycemic activity;
3. atherosclerosis: Glossy Privet Fruit is rich in linolic acid, linolic acid.Its decoction alcoholic solution can increase the extrasomatic rabbit heart coronary flow, can suppress myocardial contraction and not increase heart rate simultaneously.This is its blood fat reducing, improves the foundation of blood supply of cardiac muscle.Glossy Privet Fruit can be prevented and treated atherosclerosis, and the bar number that can reduce coronary artery lipid pathology also can alleviate the degree of coronary occlusion.Oleanolic Acid is by reducing lipid peroxide, protection PGI 2Synthetic enzyme suppresses TXA 2Generation and activity, rising PGI 2/ TXA 2Ratio suppresses smooth muscle cell proliferation, reduces foam cell formation, thereby obviously suppresses the formation of atherosclerotic plaque, and atherosis develops.Single Glossy Privet Fruit honeyed bolus has the effect that reduces serum cholesterol, and the effect that reduces serum lipoprotein is also arranged;
4. anti-ageing: the Cognex of being made up of Glossy Privet Fruit, Tuber Fleeceflower Root, the red sage root etc. of promoting blood circulation passes through to reduce endothelin, the rising calcitonin gene is relevant, reach the energy metabolism of expansion of cerebral vascular, cerebral blood flow increasing amount, promotion neurocyte, the effect that the cranial nerve cell function is recovered again;
5. remove free radical effect Glossy Privet Fruit and effective constituent Oleanolic Acid thereof and can remove ultra-oxygen anion free radical and hydroxy radical qiao, improve the phylactic power defensive power of body free radical.Glossy Privet Fruit can significantly suppress the formation of mouse liver MDA at advanced age; Oral Glossy Privet Fruit alcohol extract can make the active raising 59% of high mouse liver SOD in the length of time;
6. protect the liver: Oleanolic Acid is to CCI 4The rat acute liver injury that causes has significant protective effect; Serum GPT content is obviously descended, and the liver fat sex change alleviates, and glycerine three junket are accumulated minimizing in the liver; Hepatocellular degeneration, necrosis obviously alleviate, and glycosuria is accumulated increase.Mitochondrial swelling and intracellular vesicle alleviate in the liver cell, and can promote liver cell regeneration.Wine steams the protecting the liver of Glossy Privet Fruit, immunoregulation effect is the strongest, and OLA content is the highest, and it is the strongest to fall the SGPT effect;
7. antitumous effect: Glossy Privet Fruit suppresses to bring into play antitumor action by the reversing tumor cell to the function of scavenger cell.Stomach, the gastral 9 kinds of cancer cells of large intestine there are the obvious suppression effect, and normal fibrocyte is had proliferation function, play inhibition and anti-metastasis effect tumour cell by the secretion that reduces matrilysin.Water extract can suppress the crosslinked DNA of Aspergillus flavus B (AFB), reduces the formation of AFB-DNA, thereby thinks that Glossy Privet Fruit can improve immunological function of cancer patients, with the same usefulness of chemotherapeutics, certain efficacy enhancing and toxicity reducing effect is arranged, and can be used as the chemotherapy preventive of tumour.
(4), Radix Panacis Quinquefolii is the dry rhizome of Araliaceae Radix Panacis Quinquefolii panax quinquefolium L..But boosting qi and nourishing yin, clearing heat and promoting fluid.Be used for that the deficiency of vital energy cloudy is lost, interior heat, cough breathe heavily phlegm blood, abnormal heat tired tired, quench one's thirst, disease such as dryness of the mouth and throat.
1. effect Radix Panacis Quinquefolii and other herbal medicine of central nervous system are formed No. 1, antifatigue, can alleviate lacticemia, stablize erythrocytic structure and function, increase generation, raising blood oxygen capacity and the oxygen content of blood of oxyphorase and strengthen blood and take oxygen and, promote the self-control of fuselage state to organizing oxygen delivery capacity.American ginseng total saponins can suppress nervus centralis, and the forming of lipid peroxide can significantly suppress in the mouse brain tissue to cause anoxic by potassium cyanide the time;
2. to the effect stem and leaf of Radix Panacis Quinquefolii total saponins 50～100mg/kg of cardiovascular systems, can significantly reduce necrotic myocardium area under the stress situation, reduce the activity of serum paraoxonase acid kinase (CK), serum lactic dehydrogenase (LDH).During Radix Panacis Quinquefolii glycol saponins injection liquid intravenous applications, patient's serum glutamic oxalacetic transaminase (SGOT), LDH, the Q-hydrocarbon butyric acid dehydrogenation acid (activity of α-HBDH), creatine phosphokinase (CK), CPK-MB (CK-MB) and serum lipid peroxide (LPO), all be starkly lower than control group, and the activity of superoxide-dismutase (SOD), glutathione peroxidase (GSH-PK) all is higher than control group;
To the effect Radix Panacis Quinquefolii saponin of Digestive tract to intoxicated choline of second (ACH) or potassium depolarize after the caused rabbit of the calcium ion ileum that exsomatizes shrink, according to dosage dependency situation obviously suppresses, it is noncompetitive antagonism to the amount effect curve of calcium chloride, in the stripped ileum cell that second phthalein choline is caused and the contraction of extracellular Ca2 ionic dependent, has the obvious suppression effect;
4. leukocyte increasing American ginseng root Crude polysaccharides (PPQ) can be prevented leukocytic reducing in the blood circulation, also can make the thymus gland of the immunosuppressed mice of CY generation, spleen weight increase the phagocytic function of the low mouse reticuloendothelial system of enhancing immunity;
5. liver protection effect stem and leaf of Radix Panacis Quinquefolii saponin(e can reduce the activity of alanine aminotransferase in the serum, and mda (MDA) content is descended, and increases the activity of hepatic glycogen content and glutathione peroxidase, to alleviate CCI 4The rats'liver damage that causes;
6. antitumous effect ginsenoside-Rh 2To mice lung cancer cell, B 16Melanoma cell, rat Momis liver cancer cell have tangible tumor-inhibiting action, and suppress murine sarcoma S 180Induce differentiation again with mouse EAC.
(5), glossy ganoderma is the red sesame Ganoderma of polyporaceae fungi Lucidum (Leyss.ex Fr.) Karst. or purple sesame Ganodema sinense Zhao, the dry sporophore of Xu et Zhang.But tranquilizing by nourishing the heart, benefiting qi and nourishing blood, relieving cough and asthma.Be used for cough due to consumptive disease, the deficiency of vital energy, forgetful insomnia, dreaminess, the motive deficiency of blood, diseases such as body void, malnutrition after being ill.
1. adjusting immunization: Ganoderma spore powder has enhancement to the Turnover of Mouse Peritoneal Macrophages phagocytic function, mouse spleen index and the also corresponding increase of acid non-specific junket enzyme dyeing, and the prompting glossy ganoderma can strengthen non-specific immune function.Glossy ganoderma can strengthen engulfing of reticuloendothelial system and remove the foreign matter ability.The aqueous extract of Ganoderma spore powder can activating macrophage, and glucocorticosteroid is arranged anti-effect;
2. hypoglycemic activity: glossy ganoderma different sites and extract all have in various degree influence to blood sugar.The mechanism of its blood sugar reducing function is because it can increase the concentration of plasma insulin, quicken the metabolism of glucose, it can not only increase the utilization of surrounding tissue to sugar, and can also improve the utilization of liver to glucose by strengthening the activity that participates in the glycometabolic various key enzymes of liver;
3. hepatoprotective effect: pharmacological testing shows: Ganoderma spore powder has certain protective role to D-Gal induced mice hepatic pathology model, but the glossy ganoderma blood fat reducing;
(6), be the piece root of liliaceous plant Ophiopogon tuber of dwarf lilyturf japonicus (L.f.) Ker Gawl. the tuber of dwarf lilyturf.But nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.Be used for diseases such as dryness of the lung dry cough, the cough of empty hemorrhoid, thirsty, the vexed insomnia of Tianjin wound, interior heat are quenched one's thirst, the dry constipation of intestines, pharyngeal diphtheria.
1. to the effect of myocardial infarction: Radix Liriopes amino acid, Radix Liriopes Proliferae total saponins, the activity of the superoxide-dismutase of the release of phosphocreatine creatase and protection ischemic myocardial in the inhibition myocardial infarction cardiac muscle serum, reduce lipid peroxidation product cardiac muscle mda and generate, can significantly reduce Rat of Myocardial Infarction free serum lipid acid level;
2. to the immunity system effect: but the short grass Radix Liriopes saponin(e C significant prolongation mouse survival time extremely significantly increase mouse immune organ thymus gland, spleen weight, the carbon granule that can significantly increase mouse is cleaned up effect;
3. to the influence of gastrointestinal motility function: the tuber of dwarf lilyturf oral liquid as barium agent gi tract propelling agent, show the significantly prograding in accelerate gastrointestinal road;
4. antitumor action: liriope muscari Baily saponin(e C under the situation of dosage 20mg/kg to S 180Sarcoma has antitumor activity.Under the situation of intraperitoneal administration, ehrlich carcinoma has antitumor activity;
5. hypoglycemic activity: the single oral dose Radix Ophiopogonis polysaccharide has obvious reduction effect, and oral back 4-1Ih hypoglycemic activity is obvious, still has blood sugar reducing function in 24 hours.
(7), radix polygonati officinalis is the dry rhizome of liliaceous plant radix polygonati officinalis PoIygonatum odoratum (Mill.) Druce.But nourishing YIN to relieve dryness promotes the production of body fluid to quench thirst.Be used for lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior heat disease such as quench one's thirst.
1. to immunity function: Rhizoma Polygonati Odorati extract (PAOA) has restraining effect to its lymphocyte transformation.Point out the immunologic function of this medicine possibility suppressor T cell mediation.In addition, the PAOA abdominal injection has obvious restraining effect to the rate of formation of mouse E bow structure, illustrates that this medicine may be a kind of novel immunosuppressor;
2. tonifying Qi antitussive action: the bagged steeping drug that radix polygonati officinalis, the tuber of dwarf lilyturf make shows by experimentation on animals: the effect of tool Yin-nourishing and Qi-supplementing, the cough-relieving of promoting the production of body fluid;
3. hypoglycemic activity: the radix polygonati officinalis methanol extract can reduce the blood sugar that STZ brings out the hyperglycemia mouse, suppresses the effect that suprarenal gland brings out the hyperglycemia mouse blood sugar simultaneously in addition.The propyl carbinol soluble part of methanol extract can obviously reduce the blood sugar that STZ brings out the hyperglycemia mouse behind administration 4h;
4. the guarantor that myocardial cell's anoxic is lacked sugar is jealous of the effect experimentation on animals to show: the radix polygonati officinalis tool is certain improves the myocardial function effect.
(8), the Radix Astragali is the dry root of leguminous plants Mongolia Huang Shi Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or yellow luxuriant Astragalusmembranaceus (Fisch.) Bge. of film pod.Spring, two seasons of autumn excavate, and remove fibrous root and root head, dry.But invigorating QI to consolidate the body surface resistance, diuresis holder poison, apocenosis, expelling pus and promoting granulation.Be used for that the deficiency of vital energy is weak, anorexia and loose stool, sinking of QI of middle-JIAO, for a long time rush down prolapse of the anus, the uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer difficultly burst, burst for a long time do not hold back, the deficiency of blood is sallow, interior heat is quenched one's thirst and diseases such as chronic nephritis proteinuria, diabetes.
1. to the therapeutic action of nephrotic syndrome: by the Radix Astragali studies show that the nephrotic syndrome rat: the Radix Astragali can make the kidney of nephrotic syndrome that albumin excretion rate is reduced, raise simultaneously seralbumin, reduce blood cholesterol and glycerine three cruel, clinical nephrotic syndrome is had certain therapeutic action.Point out the formulation of astragalus root partner treatment that the optional friend of clinical nephrotic syndrome patient is inexpensive, nontoxic, side effect is little;
2. to the diabetic nephropathy myocardial protective effect: studies show that: the Radix Astragali can suppress the effect of diabetic nephropathy Myocardial Lipid Peroxidation and reduce nitric oxide level, and the protection cardiac muscle is avoided lipid peroxidation and nitric oxide production damage;
3. cardiotonic: the Radix Astragali has its contraction of reinforcement to normal heart, to because of poisoning or tiredly sinking into depleted heart, act on more obviously, shows as and makes heart that contractive amplitude increase effect be arranged, the discharge hypervolemia;
4. hypotensive effect: this product can make coronary vasodilator and renal blood vessels expansion, and just the expansion of whole body peripheral vessel improves cutaneous circulation, makes patient's blood pressure drops.Its to antiadrenergic drug, bring high blood pressure down directly relevantly with vasodilation, step-down may be for containing the effect of r-aminobutyric acid;
5. diuretic properties: oral or injection formulation of astragalus root, all proof has diuretic properties, and the trier carries out diuretic test on one's body, prove that the Radix Astragali has medium diuretic properties.
(9), Tuber Fleeceflower Root is the piece root of polygonum multiflorum thunb Polygonum multiflorum Thunb..But invigorating the liver and kidney, benefiting essence-blood, black beard and hair, strengthening the bones and muscles.Be used under sallow, the dizzy tinnitus of the deficiency of blood, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, the uterine bleeding band, disease such as weakness due to chronic disease, hyperlipidaemia.
1. to immune effect: Tuber Fleeceflower Root can significantly increase mouse thymus, lymphonodi coeliaci, adrenal weight, and spleen has weightening finish trend; Simultaneously also can increase normal total white blood cells, leukopenia effect due to antagonism Ultracortene-H immunosuppressive action reaches; Improve the phagocytic activity of Turnover of Mouse Peritoneal Macrophages; And can significantly resist mouse thymus atrophy and the strong white decline of serum ball that radix bupleuri decoction or hydrocortisone cause;
2. to the effect of the recycle system: the Radix Polygoni Multiflori Preparata decoction irritates that ECG T wave that stomach causes rabbit cardiac muscle due to the Posterior Pituitary is towering obviously to be alleviated, and can cause the decreased heart rate that the antagonism Posterior Pituitary causes, but the disorderly no antagonistic action of the heart rate that Posterior Pituitary is caused.The Tuber Fleeceflower Root injection liquid can slightly increase the coronary flow of extrasomatic rabbit heart, and intravenous injection Tuber Fleeceflower Root injection liquid is accelerated the rabbit heart rate to Racemic isoproterenol does not have antagonistic action;
3. anti-microbial effect: the in-vitro antibacterial experiment shows: Tuber Fleeceflower Root and processed product decocting liquid thereof all have restraining effect in various degree to streptococcus aureus, shigella flexneri, sonne bacillus, Corynebacterium diphtheriae, paratyphosum Bacterium B, Nai Shi catarrh bacterium, diphtheria corynebacterium, beta hemolytic streptococcus etc.Living, Radix Polygoni Multiflori Preparata all has certain anti-microbial activity, and wherein the anti-streptococcus aureus effect of Radix Polygoni Multiflori is stronger than the whole bag of tricks processed product.The black juice steam tuber of multiflower knotweed steams the tuber of multiflower knotweed to Staphylococcus albus, wine diphtheria corynebacterium inhibition ability is better than the product of giving birth to and other processed products.
(10), wolfberry fruit is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Can be nourishing liver and kidney, replenishing vital essence to improve eyesight.Disease such as be used for that consumptive disease smart loses, soreness of waist and knee joint, dizzy tinnitus, interior heat are quenched one's thirst, the deficiency of blood is sallow, blurred vision is not clear.
1. anti-oxidant, anti-aging effects: experimental study shows: medlar extract liquid has the generation of obvious inhibition liver homogenate lipid peroxide (LPO), and be dose-response relationship, and (GSH-Px) vigor of Selenoperoxidase in the blood and erythrocyte sod vigor are increased.In addition, wolfberry fruit has inhibition CCl 4Cause the effect of lipid peroxidation;
2. antitumor action: the matrimony vine essence can obviously suppress rat sarcoma W 256Growth, and can prolong the life of ehrlich carcinoma mouse.The saturating outer liquid of matrimony vine, Chinese scholartree seed, Chrysomyia megacephala (Fabricius) strengthens the mouse boosting cell killing activity to some extent.The outer liquid of matrimony vine can suppress S in the mouse body 180Growth; Operation back mammary cancer patient uses the injection of matrimony vine small molecules extracting solution, and the killing activity of its peripheral blood lymphocyte is apparently higher than control group.Matrimony vine divides subconstiuent after heat treated, and its validity disappears;
3. enhancing body immunization: experimental research suggested: it is to suppress the mechanism of tumor effect that lycium barbarum polysaccharide increases the mice with tumor cellular immune function.Lycium barbarum polysaccharide is a kind of biologically active substance that extracts from wolfberry fruit, have immune cell functions such as T, B, CTL, NK and the MQ of promotion, promote cytokines such as IL-2, IL-3, TNFB to produce, strengthen the effect of lotus knurl, chemotherapy and radiation murine immunologic function and adjusting neuroendocrine immunomodulatory (NTM) network.
(11), the mulberry chess piece is the dry fruit ear of moraceae plants mulberry Morus alba L..The enriching yin of can enriching blood is promoted the production of body fluid and is moisturized.Be used for diseases such as dizzy tinnitus, palpitation and insomnia, beard and hair.
1. to immune effect: experiment shows: 100% mulberry wedge decocting liquid all has significant increase effect to body weight, spleen, thymic weight and the serum carbon clearance speed of asthenic symptoms mouse due to the hydrocortisone;
2. antimutagenic: use the mouse marrow cell micro nuclear test method, observe fresh mulberry chess juice brings out the mouse polychromatic erythrocytes micronucleus to CY restraining effect.Found that: fresh mulberry chess juice has the effect (P＜0.05) that CY brings out the rising of marrow micronuclear rates that suppresses, and tangible dose-response relationship (r=0.94) is arranged, illustrate that fresh mulberry juice has certain anti-mutagenic activity, may have certain preventive effect the mutagenesis of some external mutagenic compound.
(12), date is the dry mature fruit of Rhamnaceae plant jujube Ziziphus jujuba MiIl..But invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Be used for insufficiency of the spleen food less, disease such as weak loose stool, gynaecology's deficiency of blood amenorrhoea.
1. immunological stimulation: date can significantly improve the phagocytic function of monokaryon-macrophage system in the body.Jujube polysaccharide can significantly strengthen the secreting function of the little secretion of M φ to the cytotoxicity of L929 cell strain and TMF-Q, lL-l, NO.Survey splenocyte propagation degree with mtt assay, the result shows: jujube polysaccharide can promote mouse boosting cell propagation, and effect presents the back downtrending that raises earlier, and optimal concentration is 100 μ g/ml.Date Crude polysaccharides, neutral polysaccharide, acidic polysaccharose all promote lymphopoiesis, but neutral polysaccharide promotes proliferation function than acidic polysaccharose strong (relevant with its chemical constitution and molecular weight size).Give the continuous jujube polysaccharide that gavaged in 7 days of mouse, can significantly improve the phagocytic function of mouse peritoneal cell, promote hemolysin and hemolysis plaque, promote lymphocyte transformation and improve the peripheral blood lymphocyte decomposition;
2. anti-oxidant and anti-aging effects: the Fructus Jujubae extract of various dose all can improve mouse brain tissue SOD activity, and can reduce MAD content in the cerebral tissue, Wheat Protein.That gives semi-lactosi causes failure model mouse gavaging jujube polysaccharide, can obviously delay the mouse aging, can improve aging model mouse blood SOD and CAT vigor, reduces LPO level in brain homogenate, liver homogenate and the blood plasma.Jujube polysaccharide has the effect of removing free radical.The date extracting solution has tangible removing O 2The effect of-free radical can obviously suppress mouse liver homogenate peroxidatic reaction of lipid when 2.08mg/ml concentration.Jujube polysaccharide can make that thymus gland thickening, thymus gland spleen cell plastid number increase, the spleen trifle becomes big, splenic lymphocyte number and increases;
3. antitumor action: the date mixture has certain inhibition to mouse breast cancer but has no side effect.The date water soluble extract has significant inhibitory effect to the propagation and the colony formation ability of human leukemia K562 cell.The date neutral polysaccharide does not have direct tumor killing cell effect, but can suppress tumour indirectly by effect and immunocyte.Date has certain restraining effect to the rat stomach gland cancer that N monomethyl-N one nitroguanidine (MNNG) brings out;
4. antimutagenic effect is the date decocting liquid 20ml/kg of 0.5g/mI to mouse gavaging concentration, and the SEC value that can obviously reduce caused by cyclophosphamide raises, and showing has antimutagenic effect.
(13), skunk bush is the drying and ripening pulp of Cornaceae plant skunk bush Cornus offcinalis Sieb.etcucc..Can tonify the liver and kidney, puckery essence is taken off admittedly.Disease such as be used under dizzy tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, the uterine bleeding band, profuse sweating collapse, interior heat are quenched one's thirst.
1. immunoregulation effect: the aqueous extract of skunk bush can strengthen the non-specific immune function of normal mouse.The skunk bush water decoction has certain enhancement to humoral immunization.Fructus Corni total glycosides can suppress inducing of mixed lymphocyte reacion, inhibition CTL and breed, suppresses the IL-2 receptor expression, and total glycosides part is many-sided to immunosuppressive action.Mainly be that carbohydrate shows as immuno-potentiation in the skunk bush aqueous extract, total glycosides shows as immunosuppressive action, and the mechanism of action difference;
2. anti-inflammatory action: skunk bush water decoction p-Xylol, egg white etc. cause inflammatory exudation that scorching thing causes and tissue edema and granulation tissue hyperplasia and all have the obvious suppression effect.Fructus Corni total glycosides has remarkable restraining effect to rat assist agent arthritis;
3. hypoglycemic activity: skunk bush alcohol extracting thing can reduce normal mouse blood sugar, also can reduce the tetraoxypyrimidine hyperglycemia.The ether extract of skunk bush and effective constituent thereof have the effect of tangible reduction glucose in urine, and have confirmed that further urson (ursolic acid) is the antidiabetic activeconstituents of skunk bush;
4. Antishock function: the skunk bush injection liquid can increase myocardial contraction, improves cardiac efficiency, the expansion peripheral blood vessel, increase cardiac pumping function, helps the treatment of hemorrhagic shock;
5. antioxygenation: the skunk bush tannic acid can suppress lipid peroxidation, stops steatolysis, also can suppress suprarenin and adrenocortical hormone and promote steatolysis.The content effect of skunk bush increase Hb is obvious, energy antifatigue, hypoxia tolerance and memory.The skunk bush aqueous extract can obviously improve the vigor of SOD in the red corpuscle, and water decoction is to the effect of being significantly improved of rat heart muscle SOD vigor;
6. diuretic antihypertensive effect: the skunk bush fluid extract has the diuresis hypotensive effect to anesthetized dog;
7. bacteriostatic action: ursolic acid may be to suppress white to read bacterium and the red main component of reading fungal growth, skunk bush decocting liquid has restraining effect to streptococcus aureus, Corynebacterium diphtheriae and dysentery bacterium, and water logging agent in 1: 3 has in various degree restraining effect to 10 kinds of fungies such as trichophyton in vitro;
8. hepatoprotective effect: Oleanolic Acid has the effect of similar Broad spectrum antibiotics, to because CCl 4The rat ALT that causes raises obvious effect, also is used for the treatment of acute viral hepatitis clinically;
9. antitumous effect: skunk bush decocting liquid is outer can to kill whole mouse ascites cancer cells, and spermary cell, salivary gland cell are also had similar killing effect;
(14), Herba Cistanches is the chylocaulous of the arid zones scale leaf of orobanchaceae plant cistanche Cistanche deserticola Y.C.Ma.But kidney-replenishing, benefiting essence-blood relaxes bowel.Be used for diseases such as impotence, infertile, soreness of the waist and knees, muscles and bones are unable, the dry constipation of intestines.
1. radio-protective effect: mouse is behind various dose Co60 gammairradiation, and clothes can make the impaired humoral immunization of mouse, cellular immune function and non-specific immune function recover with cistanche glycosides (GCS);
2. the effect of enhancing immunity: GCS has and promotes that nucleic acid is synthetic, reduces that nucleic acid decomposes and the bad effect of glass, further promote proteinic synthetic, thereby help phylactic agent to generate, quicken histiocytic reparation and regeneration, improve the body defence capability;
3. anti-aging effects: the Herba Cistanches polysaccharide can suppress the lung collagen protein to be increased and reduces and change the unbalance of body oxidation and anti-oxidant function with elastin, and directly or indirectly remove the detrimental effect of radical pair body, the free-radical generating that elimination D semi-lactosi causes increases, and has avoided disappearing because of the oxidation-resistance material.
(15), glutinous rehmannia is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..But clearing heat and cooling blood, yin-nourishing is promoted the production of body fluid.Be used for that the deep red polydipsia of pyreticosis tongue, interior-heat caused by deficiency of YIN, hectic fever due to yin labor heat, interior heat are quenched one's thirst, haematemesis, bleeding from five sense organs or subcutaneous tissue, send out disease such as spot dermexanthesis.
1. vasodilation and reducing heart rate effect: glutinous rehmannia has stronger physiologically active to cardiovascular systems, and is bigger to the heart function influence.Low dose makes vasoconstriction; Heavy dose distends the blood vessels.Wine prepared glutinous rehmannia and Radix Rehmanniae Preparata all have remarkable hypotensive effect, and systolic pressure and diastolic pressure all significantly descend.And heart rate had certain influence, show as decreased heart rate more.Electrocardiogram(ECG is observed after taking Radix Rehmanniae Preparata: myocardial strain, left ventricle high pressure and deficiency myocardial blood supply that hypertension is caused all have the improvement effect.Radix Rehmanniae Preparata after the wine system all has the rising effect to cholesterol and triglyceride level, and with the Radix Rehmanniae Preparata of wine cholesterol is not had tangible reduction effect;
2. the effect of raise immunity: the effective constituent Dihuang polysaccharide of glutinous rehmannia can obviously promote LonA inductive T lymphproliferation response.In vivo, can obviously improve T lymphopoiesis ability, also can significantly promote the secretion of the dirty T lymphocyte of mouse IL-2;
3. antitumor action: Dihuang polysaccharide body innerlich anwenden then can obviously improve tumor-bearing mice splenic T lymphopoiesis ability, improve the effect of its LTL sample killing tumor cell, the NK cell viability decline that causes because of tumor growth and the effect that goes down of IL-2 secretion capacity can also be improved simultaneously relatively, tumor-bearing mice CD4 can be stoped effectively +/ CD8 +Ratio rises, and makes to have to carry out the CD8 that kills the knurl function +Subgroup is had the advantage, and brings into play its tumor-inhibiting action;
4. the effect Dihuang polysaccharide of strong hemopoietic function of bone marrow can obviously increase the colony forming efficiency of normal mouse marrow grain monosystem cell (LFU-GM) and the peripheral white blood cell that obviously raises.
(16), longan aril belongs to Sapindaceae, aiphyllium, vegetative period, 2-7 was between the month.Fruit is heart-shaped circular, the most fish-scale shape of pericarp tool projection, scarlet purplish red, viridescent or Bluish white.Half is distinct when arillus (being commonly called as " pulp ") was fresh, the congealed fat shape, and succulence, it is sweet and refreshing to distinguish the flavor of, and fragrance is arranged, and fruits nutrition is abundant, and soluble solid reaches 12.9%-21.0%.
(17), Formica fusca: Ming Dynasty's LI Shi-Zhen claims that ant is " a profound coltfoal ".Edible, medicinal big Formica fusca is through being accredited as swollen wing order Formicidae Polyhachis vicina Roger.The ant tonic wine is to be a kind of novel nourishing wine as health-care beverage that the fermenting raw materials brew forms with ant and glutinous rice.This wine wine liquid clear, vinosity are mellow, unique style, contain nutritive ingredients such as rich in amino acid.
China is edible, medical ant has history in 3000.Our ancestors find to have healthy and strong strong physique behind the animal food calling ants such as bear, Squama Manis for a long time, also begin edible ant.The JINGANG WAN of Han dynasty treatment muscles and bones weakness is used ant making pellets by mixing medical powder with honey system exactly.Record among the Song dynasty Zhang Huicun " rebuilding is had stable political situation through history card class preemergency wood grass ": " solely ant function same Vespa simillima Smith in angle cures mainly spider and stings and treat the subcutaneous ulcer disease ".Before several years, on the judging panel who is made up of 12 trophology, Chinese materia medica and sommelier, brainstrust thinks that ant has very high nutritive value and pharmaceutical use, and slight ant is a seat " a nutrition treasure-house ", but edible ant tonic wine physique enhancing and bone strengthening.Through Colleges Of Traditional Chinese Medicine Of Guangxi, Chinese Institute of Preventive Medicine's food and nutrient research institute, Beijing nutrition source institute aboundresources, Analysis of Nutritional such as Polyhachis vicina Roger relatively more commonly used are proved: its protein is between 42%-67%, 8 kinds of indispensable amino acids of 28 kinds of total free aminoacidss, human body are complete, contain vitamins B 1, vitamins B 2, vitamins B 3, vitamin-E and mineral calcium, phosphorus, iron, selenium, zinc etc., than horn of plenty, every 100g Formica fusca contains zinc 12～13mg with zinc, also has plurality of enzymes, steroid compounds, triterpene compound, cursive script formaldehyde (citral), formic acid etc.
Through judging and measuring, the ant tonic wine has abundant nutrition, and its nutritive value is as follows:
1. amino acid kind and content ant tonic wine thereof contain 19 seed amino acids, and total amount reaches 6830mg/100mL, and human body 8 seed amino acids are complete.The aminoacids content of ant tonic wine is respectively 1.2 times of rice wine, 1.63 times of Japanese sake, 6.89～11.9 times of beer, 4.287 times of red wine;
2. inorganic salt and micro-ant tonic wine contain the inorganic salt such as potassium, sodium, calcium, magnesium of needed by human, also contain body metabolism trace elements necessary iron, copper, manganese, zinc etc.
(18), walnut: walnut claims English walnut again, belongs to walnut section Juglans by botany classification, amounts to more than 20 kind.Walnut is long at China's cultivation history, and cultivated area is very wide.Walnut nutritious value is very high, contains the essential various nutrients of body.Pharmaceutical use is quite extensive, is referred to as the ideal nourishing food by the successive dynasties physicians.The walnut kernel oleaginousness is about 63%, and protein content is only second to soybean between 15%-35%, and is more taller than the content of beef.The content of Methionin has surpassed yolk in the protein, belongs to high-quality protein.The Juglans high lipid food can be human body the sufficient amount of heat source is provided.Phosphatide and fat-soluble vitamin-E, be keep the human body normal neurological function can not the few material of seedling, and walnut content is abundant, for inspire enthusiasm, hypermnesis, diseases prevention be healthy and strong very useful.Modern medicine proves: phosphatide has obvious curative effects to treatment arteriosclerosis, reduction body inner cholesterol content, prevention fatty liver and chronic eczema disease.
In addition, walnut also contains a lot of iron and vitamin B group, is that human body normal physiological function institute is indispensable.In the U.S., Japan, be arranged as: 1. blend fiber with heath food sales volume order; 2. vitamin-E; 3. phosphatide; 4. protein.Back three kinds of content in walnut in these four kinds of materials are all quite abundant.Rich nutrient contents that is contained in the walnut and tonic effect are familiar with by people, if can reasonably develop, develop deep processing at many levels, will improve the output value of walnut product greatly, increase economic benefit, and the exploitation of walnut wine series products is one of approach.
(2). the fire internal organ nourishing wine that the present invention makes be safran, wine body clear and bright, light is arranged, no suspended substance does not have precipitation, and is sweet refreshing clean, the fragrance harmony, pleasant impression is long, free from extraneous odour has the typical style of strong pure wine.
1. Oranoleptic indicator
Look: pale brown look, transparent, no suspended substance and throw out.
Fragrant: as to have the Shu Yu fragrance of this special material of vegetalitas medicine, the fragrant harmony of medicine cordiale.
Flavor: the inlet linearity is just sweet, and back mildly bitter flavor has this product peculiar flavour.
2. physical and chemical index
The wine degree (32 ℃, %) 38 ± 1
Total acid (with citrometer, g/100mL) 0.1-0.2
Total reducing sugar is (with glucose meter, g/L)≤80
Protein content (%) 〉=15
Carbohydrate (%)≤50
Iron (mg/100g) 10-12
Zinc (mg/100g) 8-11
Plumbous (in Pb, mg/kg)≤0.50
Arsenic is (in As, mg/kg)≤0.30
Copper is (with Cu juice, mg/kg)≤5.0
3. microbiological indicator
Total plate count (individual/g)≤10000
Coliform (individual/100g)≤90
Pathogenic bacterium do not detect
(3). the quality test of fire internal organ nourishing wine of the present invention and detection
Chinese medicine preparation is the important component part of motherland's medicine and pharmacology, be China people for thousands of years in the practice of waging a struggle with disease, the precious legacy that accumulation sums up out, it have ever made huge contribution to the history of for the health and the existence procreation of the Chinese nation.At present, Chinese medicine preparation is being waved effect positive, that do not replace as clinical widely used medicine at people's sanitary health career relaying supervention.
Medicine is the important substance of preventing and curing diseases, and has significant singularity.The quality of its quality not only directly influences result of treatment, and is related to the people's health and life safety.Therefore, must strictly control and management the quality of medicine, with security and the validity of guaranteeing people's medication.For this reason, country has taked a series of measures, has issued and implemented " The Drug Administration Law of People's Republic of China "; Set up special State Food and Drug Administration of administrative service division, be responsible for administrative supervision and technical supervision are carried out in research, production, circulation, the use of medicine.Formulateeed and implemented " Good Manufacturing Practice and Quality Control of Drug " (GMP), the GSP (GSP), " Chinese medicinal materials quality of production management regulation " (GAP), " clinical drug trial management regulation " a series of drug control laws and regulations such as (GCP), revision regularly, the promulgation national drug standards, set up the drug testing institutions at different levels, carry out drug inspection work.Stipulate that clearly drug quality must meet the national drug standards, defective medicine does not allow to produce and sell and use.Thereby make drug quality management and drug inspection work receive people's legal track.The Chinese medicine vina must carry out quality examination to it as medicine in accordance with the law, and this is the important means of country to the supervision of medicine technical application, and is significant for assurance and raising Chinese medicine preparation quality.
Because the chemical ingredients of Chinese medicine preparation is quite complicated, effective constituent is still not fully aware of, and therefore traditional detection method is difficult to reflect the quality of preparation objective and accurately.Along with progress of science and technology, what chemical composition of Chinese materia medica was studied deepens continuously and multi-disciplinary cooperation, the widespread use of especially various Modern Instrument Analytical Techniques in drug inspection, and Chinese medicine vina check modernization process is accelerated.Modern Instrument Analytical Technique has efficiently, fast, characteristics such as trace and level of automation height, can carry out meticulous separation to various ingredients in the Chinese medicinal liquor agent, provide abundant simultaneously and qualitative, quantitative information accurately.
The check of Chinese medicine vina is control, the important technical of estimating Chinese medicine vina quality.Can not only negatively make whether qualified judgement as Chinese medicine vina reviewer to the vina finished product, also should understand the various factors that influences the vina quality more all sidedly, thereby by quality test, analyze and solve the quality problems that exist in the production, for realizing that drug quality management provides scientific basis and technical guarantee.
The amount of alcohol assay method
Amount of alcohol is measured and to be meant with certain method mensuration vina and contain alcoholic acid vol (%) 20 ℃ the time.
Ethanol is to the dissolving power difference of various compositions in the medicinal material, the height of amount of alcohol is all influential for stability of wherein kind, quantity and the vina of content of effective and impurity etc. in the vina, so the amount of alcohol inspection is an important quality control index of preparations such as vina, tincture, fluid extract, especially still do not have the vina of proper content measuring method for those, it is even more important then to seem." Chinese pharmacopoeia has been recorded two kinds of amount of alcohol test procedures, that is: vapor-phase chromatography and distillation method.When being made the tonic wine check, the present invention uses the gas-chromatography working method.
1. the preparation of standardized solution: dehydrated alcohol 4ml, 5ml, 6ml that precision is measured constant temperature to 20 ℃, put in the 100ml volumetric flask, accurate respectively each 5ml of n-propyl alcohol that adds constant temperature to 20 ℃ when thin up becomes 100ml, shakes up promptly.
2. the preparation of need testing solution.Precision is measured trial-product an amount of (being equivalent to ethanol 5ml approximately) and the n-propyl alcohol 5ml of constant temperature to 20 ℃, and thin up becomes 100ml, shakes up promptly.
Standardized solution and need testing solution can further dilute in case of necessity.
3. chromatographic condition and system suitability test.The chromatographic column that aged divinylbenzene-EST type porous polymer beads is housed is connect people's gas phase bag spectrometer, connect detector, column temperature is 120-150 ℃, detector, sample introduction temperature are 170 ℃, and constant temperature is after the characteristic spectrum baseline stability, according to the gas-chromatography marker method, get above-mentioned 3 parts of each sample introductions of standardized solution minimum 2 times, measure, the record color atlas should meet the following requirements:
1. the number of theoretical plate that calculates with the n-propyl alcohol peak should be greater than 700;
2. the resolution at ethanol and n-propyl alcohol two peaks should be greater than 2;
3. above-mentioned 3 parts of solution are respectively annotated sample 5 times, and the relative standard deviation of 15 correction factors of gained must not be greater than 2.0%.
(4) mensuration of need testing solution.Get standardized solution (the most close in above-mentioned 3 parts of standardized solution) and need testing solution an amount of (being equivalent to the about 5ml of ethanol) with the need testing solution alcohol concn, annotate sample 3 times continuously respectively, and calculate ethanol content in correction factor and the trial-product, get the mean value that calculates for 3 times as a result of.
The ethanol-soluble extractives assay method
This law means that with methyl alcohol, ethanol or propyl carbinol be solvent, extracts corresponding pure soluble components in the medicine, and calculates its content (%).Propyl carbinol determination of extractives method is mainly used in the vina that contains more saponin component, has more specificity.
Ethanol-soluble extractives assay method working method
(1) mensuration of methyl alcohol, ethanol soluble extraction is measured according to the water-soluble extractives assay method.
(2) mensuration of propyl carbinol extract is measured by the method for regulation under each kind item.In general, aqueous solution preparation can be directly with water saturated n-butanol extraction for several times, united extraction liquid places the furnace pot of dry constant weight, evaporate to dryness, put 105 ℃ of dry 5h, in the dislocation drying basin, cooled off 30 minutes, weight decided in accurate rapidly title, the content of propyl carbinol extract in the calculating trial-product (massfraction, %).Solid preparation can be dissolved in water earlier, move in the separating funnel, with water saturated n-butanol extraction for several times, united extraction liquid, according to the aforesaid method evaporate to dryness, drying claims to decide extract weight, calculate propyl carbinol extract in the preparation content (massfraction, %).
The special impurities test procedure
Because source difference, preparation method's difference, the formulation difference of various medicines, even same kind also can be taked different production process routes, and medicine also has the product that different decomposition changes in storage process.Therefore the inspection of medicine should be checked according to the impurity that this vina might be introduced in production and storage process, and as introducing genseng etc. in the Radix Panacis Quinquefolii, these impurity are called special impurities.This inspection is in that " Chinese pharmacopoeia was listed in the version under the inspection item of each medicine in 2005.The inspection of special impurities generally is to utilize the physico-chemical property of medicine and impurity and the difference of physiological action, adopt physics, chemistry, pharmacology and method of microorganism carries out.
1. the inspection of genseng in the Radix Panacis Quinquefolii
The West three is the dry root of Araliaceae Radix Panacis Quinquefolii Panax quinque folium L., mainly contains the sweet (Rb of various genseng soaps 1, Rb 2, Rc, Rd, Re, Rf, Rg 1, F 3, F 11Deng) and volatile component, organic acid, carbohydrate etc., wherein contained ginsenoside is with Rb 1(C 54H 92O 23) content the highest (being no less than 1.0%).Effect with boosting qi and nourishing yin, clearing heat and promoting fluid, be mainly used in clinically that the deficiency of vital energy cloudy is lost, interior heat, cough breathe heavily phlegm blood, abnormal heat tired tired, quench one's thirst, the treatment of disease such as dryness of the mouth and throat.Genseng is the dry root of Araliaceae genseng Panax ginsengC.A.Mey., mainly contains various ginsenoside (R., R a, Rb 1, Rb 2, Re, Rc, Rd, Rg 1, Rg 2, Rh 1, Rh 2, Rh 3Deng) and organic acid, carbohydrate etc., wherein contained Rg 1(C 24H 72O 14) and Re (C 48H 82O 18) content the highest (being no less than 0.25%).Have reinforce vital energy, the treatment of diseases such as multiple arteries and veins takes off admittedly, the tonifying spleen benefit is coughed, wound thirsty, interior heat in Tianjin is quenched one's thirst, prolonged illness is emptyly won, palpitation with fear insomnia, impotence palace are cold and in heart failure, heart shock.Though both all contain ginsenoside, on kind and content, significant difference is arranged, and both functions cure mainly and are not quite similar.Because of Radix Panacis Quinquefolii mainly is import, its commodity price is several times of genseng, for consideration economically, the phenomenon of genseng has appearred on the market mixing in Radix Panacis Quinquefolii, in order to control the quality of Radix Panacis Quinquefolii, guarantee curative effect, " Chinese pharmacopoeia version regulation in 2005 should be carried out the genseng inspection to Radix Panacis Quinquefolii.
Measuring principle: in the Radix Panacis Quinquefolii with genseng in contained saponin component be not quite similar, so also difference to some extent of the thin-layer chromatography of the two can be differentiated both by this.
1. instrument and reagent
(1) instrument: glass plate (10cm * 20cm), spreader, sample applicator, double flute chromatography cylinder, analytical balance (0.0001g sensibility reciprocal), thermostatic drying chamber (being accurate to ± 1 ℃), ultra-violet lamp (365nm), ' thermostat water bath, round-bottomed flask (50ml), spherical condensation tube, furnace pot, separating funnel, mortar, micropulverizer, standard sieve.
(2) reagent, reagent: genseng control medicinal material, silica gel G, methyl alcohol, ether, propyl carbinol, chloroform-methanol-water (13: 7: 2), 10% ethanol solution of sulfuric acid.
2. working method
1. the thin layer plate preparation is with silica gel G 1Part and 3 parts in water in mortar to a direction ground and mixed, after removing the bubble on surface, in the spreader of falling people, mobile reposefully spreader is coated with (thickness is 0.25-0.5mm) on the glass plate, take off the glass plate that coats thin layer, under room temperature, put on the horizontal stand and dry, under reflected light and transmitted light, inspect, the surface should be even, smooth, no pit, no bubble do not have breakage and pollution, in 110 ℃ of bakings 30 minutes, use immediately after the cooling.
2. genseng control medicinal material 1g is got in the preparation of genseng control medicinal material solution, is ground into powder, adds methyl alcohol 25ml, reflux 1h, put coldly, filter, filtrate evaporate to dryness, residue add water 20ml makes dissolving, extract 2 times with the ether jolting, each 10ml discards ether solution, water layer extracts 3 times with water saturated propyl carbinol jolting, and each 15ml merges n-butanol extracting liquid, wash with water 2 times, each 10ml divides and gets propyl carbinol liquid, evaporate to dryness, residue add methyl alcohol 1ml makes dissolving, in contrast medicinal material solution.
3. American Ginseng powder 1g is got in the preparation of Radix Panacis Quinquefolii need testing solution, adds methyl alcohol 25ml, and reflux 1h is put cold, filter, filtrate evaporate to dryness, residue add water 20ml makes dissolving, extract 2 times with the ether jolting, each 10ml discards ether solution, water layer extracts 3 times with water saturated propyl carbinol jolting, and each 15ml merges card butyl alcohol extraction liquid, wash with water 2 times, each 10ml divides and gets propyl carbinol liquid, evaporate to dryness, residue add methyl alcohol 1ml makes dissolving, as need testing solution.
4. point sample is drawn genseng contrast solution and each 2 μ l of Radix Panacis Quinquefolii need testing solution, puts respectively on the above-mentioned same silica gel g thin-layer plate for preparing.
5. launch to have put the thin layer plate of sample and put into expansion cylinder, with 5-10 ℃ of lower floor's solution of placing 12h of chloroform-methanol-water (13: 7: 2) is developping agent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, and it is clear to be heated to the spot colour developing at 105 ℃, puts respectively under sight and the ultra-violet lamp (365nm) and inspects.
3. precaution
1. the fineness of sorbent material.The fineness of sorbent material is excessive or too small chromatography speed, separation efficiency and the value of moving are all had remarkably influenced, generally selects for use 160 purpose particles more suitable.
2. the activity of sorbent material.The activity of sorbent material or water content can influence separating effect.Heat-up time when therefore making sheet activates and temperature need be fixed the result is reappeared, so Heating temperature should be controlled at 110 ℃, the time is 30 minutes.
3. point sample, generic point is a round dot, and the point sample baseline is apart from base 1.0～1.5mm, and the sampling point diameter generally is not more than 2mm.Dot spacing is looked to influence to detect below the spot spread condition and is advisable.Must be noted that during point sample and do not damage the thin layer surface.
4. the saturated with vapor degree of developping agent in the chromatography groove.Solvent is constantly from the chromatoplate surface evaporation in the chromatography process, and its velocity of evaporation increases to both sides gradually by in the middle of the chromatoplate.When particularly being developping agent with mixed solvent, because the volatility difference of solvent, therefore in the chromatography process, middle also often different with the ratio of both sides solvent, this just makes that the Rf value of a same compound on a chromatoplate is variant, the intermediary Rf value is often littler than both sides, and this phenomenon is called fringing effect.In order to increase the saturation ratio of chromatography groove internal solvent steam, can adopt less chromatography groove or stick with the impregnated filter paper of solvent at the inwall of groove, or with chromatoplate at chromatography groove internal rotation certain hour, treat to carry out chromatography again after solvent vapo(u)r reaches capacity, so not only can avoid the generation of fringing effect, also can shorten the chromatography time simultaneously.
4. record
Genseng reference substance solution and the test sample solution spot colour developing situation under daylight and ultra-violet lamp (365nm).
5. the result judges
The trial-product chromatogram shows different spots with genseng to medicinal material, does not then sneak into the genseng special impurities in the Radix Panacis Quinquefolii.Trial-product chromatogram and genseng control medicinal material show on all four spot, then mix people's genseng special impurities in the Radix Panacis Quinquefolii.
(4). the advantage of preparation vina
1. alcoholic strength is low, and is nutritious, delicious, various in style, and effect, elegance have his own strong points.
In assembled alcoholic drinks, be the wine base divided by alcohol and liquor, the wine degree that adds the tonic wine of animals and plants medicinal material preparation and imitative west liquor outside 40 degree are above, the assembled alcoholic drinks wine degree of other types all below 40 degree, great majority 20 spend about, belong to low alcohol.Assembled alcoholic drinks has added various natural substances in order to reach certain purpose, has adjusted the color of wine base self, the molten characteristic that makes new advances that shows for one of these materials and wine based component.Therefore in the assembled alcoholic drinks except that the nutritive ingredient that contains the wine base, also contain and add the nutritive ingredient that crude substance brings to some extent, and wine base and crude substance change the nutritive ingredient that is generated because complicated physics, chemistry and thing thing chemistry have taken place in long-term co-existence, so assembled alcoholic drinks is nutritious in former wine base, and flavour is better than former wine base.
2. assembled alcoholic drinks is selected materials extensively (comprising wine base and spices), and raw material sources are extensive, abundant, sufficient, production technique and production method uniqueness, and product has typicalness.
The selecting materials of assembled alcoholic drinks is different from any liquor and fermented wine, liquor and fermented wine and concentrates on a class material basically aspect the selecting materials of fermented liquid, or starchy material, or the fruits raw material.And assembled alcoholic drinks can select for use the wine of various material productions as the wine base, can also select for use simultaneously various can flavouring, hyperchromic and increase the crude substance, wild fruit, animals and plants medicinal material, essence and flavoring agent, sweeting agent, acidic flavoring agent etc. of flavor, so the variation that extensively must bring product of selecting materials.Assembled alcoholic drinks production does not have the fixed pattern, and production technique and method decide according to the requirement of the characteristic of selected material and product fully, so all there are the technology and the method for own uniqueness in each enterprise, each product, product performance is that typicalness is also very unique.
(5). from the function of traditional Chinese medical science angle analysis tonic wine of the present invention
Vina is to be solvent with wine, effective constituent in the leaching medicine, the clear and bright leach liquor preparation of gained.Vina common name medicinal liquor.Be applicable to and take a tonic or nourishing food to build up one's health body void, rheumatalgia and wound etc. that as SHIQUAN DABU JIU, medicinal liquor for rheumatism etc., the ancient vina that claims is " the wine sweet wine ", vow sweet wine, the red Cymbidium ensifolium (L.) Sw. wine of " Jinkui Yaolue " etc. as " interior warp " chicken.Also have tincture now, also belong to a kind of of vina.Promptly according to the difference of pharmaceutical properties, with the alcohol-pickled clear and bright leach liquor of making of different concns.
The general every 100ml of tincture of severe toxicity medicine is suitable with material medicine 10g, and promptly concentration is 10%, but must do assay or titration.With the help medicine is main the composition, has help human body gas, blood, yin, yang deficiency, treats the prescription of various asthenic symptoms, the general designation tonifying recipes.According to " element is asked the three portions and nine pulse-takings opinion " " treatinging deficiency with tonification " and " element asks YIN YANG classification of natural phenomena big opinion " " weakened configuration person, warming with drugs of thick nature; Insufficiency of essence person, tonifying with drugs of thick flavor " scheduling theory is the legislation foundation.Belong in " eight treating observances " " reinforcing method ".
In traditional Chinese medicine, gas is to constitute human body and keep human life activity's the most basic material, refers to the functional activity of each internal organs again.The gas of human body is that clear depressed the closing that essential substances from water and cereals, the lung by congenital essence-QI that kidney is hidden and the life of the taste instituteization day after tomorrow sucked in the air forms, to the people grow and functional activity has effects such as important promotion, defence and nutrition.As because of the native endowment deficiency, the day after tomorrow drinking and eating irregularly, or internal organs hypofunction with age, the spleen pulmonary function reduces, and makes the reasons such as generation deficiency of gas then can cause the syndrome of the deficiency of vital energy.Mainly show as the sign of the various functional activity reductions of human body, clinical again with insufficiency of lung-QI and spleen-deficiency for the most common.Disease is seen deficiency of QI with disinclination to talk, the spontaneous perspiration of breathing hard, and phonetic sound is low, and is tired, limbs fatigue, tongue is light fat, thin white fur of tongue, deep,thready and forceless pulse etc.Be found in deficient property disease and various middle and later periods.
Five big classes such as the classification tonifying recipes can be divided into tonifying Qi, enriches blood, qi-blood tonifying, tonifying yin, yang-tonifying.
(1) tonifying Qi: be applicable to the disease that lung is spleen-lung Qi deficiency.Disease is seen lassitude, anorexia and loose stool, deficiency of QI with disinclination to talk, faint low voice, moving then shortness of breath sweating, pale tongue with white fur, feeble pulse weak person.As prolapse of the anus, uterine prolapse etc., also often be the disease of seeing of the deficiency of vital energy.
Tonifying Qi strengthens the function of spleen lung emphatically.The spleen has the function to transport and transform nutrients, and essence of water and grain and water are wet, are the foundation of acquired constitution, source of generating QI and blood, and the function of spleen is normal, and the source of generating QI and blood abundance just can provide material base for each internal organs functional activity of whole body.Lung governing qi, department breathes, and sucks clear gas, exhalation foul smell, the clear gas that the is sucked generation pectoral qi that combines with essence-QI from water and grain.The convergence of vessels in the lung, spleen biochemical cereal nutrient, mainly be the compress whole body by the convergence of vessels in the lung.If anorexia and loose stool, lassitude will appear in the hypofunction of spleen; Deficiency of QI with disinclination to talk, faint low voice, moving then shortness of breath sweating etc. will appear in the insufficiency of function of lung.If prolapse of the anus or uterine prolapse then can appear letting out for a long time in sinking of QI of middle-JIAO.Therefore, it is dirty that tonifying spleen lung two is focused in tonifying Qi.
(2) enrich blood; Be applicable to the disease of deficiency of nutrient QI and blood.Disease meeting look sallow, lip look light white, dizzy, palpitation and insomnia, tongue are light, arteries and veins carefully reaches menoxenia etc.
Heart master blood, blood stored in the liver, The spleen governs the blood is enriched blood and is worked as based on the conscience spleen." order and mend bright doctor's fingers and palms ": " conscience deficiency, all the deficiency of blood also ".Deficiency of heart-blood, the mind lose supports, then palpitation and insomnia; Blood is not gone up flourish, and then dizzy, neither Hua Erse is light for face, lip, tongue; Deficiency of heart-blood, then blood vessels do not fill, and see thready pulse without strength.Deficiency of liver-blood, sea of blood inanition is so the women is through lacking through closing.According to the principle of " reinforcing the mother-organ for treating deficiency of the son-organ ", liver is the mother of the heart, the tonifying liver so bushing is held concurrently more; Kidney is the mother of liver, the kidney tonifying so tonifying liver is held concurrently more.Spleen is a source of generating QI and blood, spleen system hypofunction and the deficiency of blood that produces, should beneficial spleen as a means of source of generating QI and blood.
Human body has temperature to support the effect of internal organs limbs and body tissue's organ, and the deficiency of yang can not be made the moon, the more women than men cold of insufficiency type syndrome that then occurs, and it mainly shows as aversion to cold and preference for warmth, pale complexion or dark and gloomy, hands and feet being not warm, pale tongue is fat and the tooth seal arranged, deep-thready pulse and slow etc.Clinical in insufficiency of the spleen-yang the most common with insufficiency of kidney-YANG.Insufficiency of the spleen-yang person doublely sees coldness and pain in the epigastrium, loose stool, aqueous-grainy diarrhea etc.; Insufficiency of kidney-YANG is then seen waist knee crymodynia, clear urine in large amounts or symptoms such as oliguria edema, impotence and seminal emission.
(3) qi-blood tonifying: as to be applicable to qi-blood deficiency disease card.Disease meeting look simple and unadorned, have a dizzy spell, palpitaition second month in a season seized with terror, the few body of food are tired, the lazy speech of breathing hard, tongue are light, and deficient and thready pulse is unable.The characteristics of its compatibility are Qi-tonifying drug and hematopoietic and use and the composition prescription, to reach qi-blood tonifying purpose.
(4) tonifying yin: the disease card that is applicable to the deficiency of Yin.Disease sees that emaciated physique, dizziness and tinnitus, hectic fever cheekbone are red, dysphoria in chestpalms-soles, night sweat insomnia, soreness of waist seminal emission, cough spitting of blood, dryness of the mouth and throat, the red few tongue of tongue, thready and rapid pulse.
Institute's Weihe deficiency of Yin refers to the hepatic and renal YIN deficiency usually.Blood stored in the liver, kidney storing essence, The liver and the kidney have a common source.The hepatic and renal YIN deficiency, asthenia of essence and blood, muscles and bones lose to be supported, cloudy essence can not on hold, so the brains inanition is emaciated physique, dizziness and tinnitus, waist soreness.Deficiency of YIN failing to restrain YANG is disturbed in the fire of deficiency type, so the hectic fever cheekbone is red, dysphoria in chestpalms-soles, dryness of the mouth and throat.The mind is disturbed, so insomnia.So fire of deficiency type punishment gold is the cough spitting of blood.Fire is disturbed smart chamber, so seminal emission.Interior-heat caused by deficiency of YIN, leak in urgent Tianjin, so night sweat.The red few tongue of tongue, thready and rapid pulse is fire excess from yin deficiency resembling.Kidney is basis of Kidney-Yin, " the Shen Shi honor is given birth to book miscellaneous diseases source and course rhinoceros candle " day: " deficiency of Yin person, Kidney-Yin void is also in the kidney." the tonifying yin method mainly is based on nourishing kidney yin.
(5) yang-tonifying: the disease that is applicable to deficiency of kidney yang.Disease meeting look pale, coldness of the body with chills, soreness of the waist and knees, spiritlessness and weakness, dysuria or frequent micturition, impotence in male, woman's fertility, pale tongue with white fur, deep,thready and forceless pulse and chi pulse person more so.
Yang-tonifying mainly is a kidney-replenishing." the Shen Shi honor is given birth to book miscellaneous diseases source and course rhinoceros candle ": " deficiency of yang person, kidney-Yang void is also in the kidney." (kidney-Yang claims Yuanyang) kidney be Yuanyang this.Be the prime mover of all functional activities of the person, the deficiency of yang can not warm body, inspires enthusiasm, so pale complexion, coldness of the body with chills, spiritlessness and weakness.Waist is a house of kidney, and kidney yang is weak, unit is empty exhausted down, so soreness of the waist and knees.The deficient kidney failing to activate functioning of QI for promoting diuresis, dysuria.Suffer from a deficiency of the kidney and can not take the photograph water liquid admittedly, bladder is not about, so frequent micturition.Kidney governing reproduction, deficiency of yang fire declines, thus impotence in male, woman's fertility.Pale tongue with white fur, deep,thready and forceless pulse is lining, void, cold resembling, CHI-pulse being weak is the performance of suffering from a deficiency of the kidney.
The moon is the basic substance of sun, and sun is that the effect of the moon embodies.Negative and positive are mutually for, promotion mutually, maintain mutually." Gu Yin does not give birth to, and solely sun is not long "." Jing Yue's complete work new side eight gusts of new general plans " said: " ... kind yang-tonifying person, must be in treating YANG within YIN ", sun is depended on to some extent, but and the cloudy medicine of mat moist to make the warm dry of positive medicine.
(6). the clinical application of the fire internal organ nourishing wine that the present invention makes
Fire internal organ nourishing wine treatment severe neurosis 98 examples of the present invention
The contriver adopts fire internal organ nourishing caudle treatment severe neurosis 98 examples of the present invention from year August April to 2000 nineteen ninety, and is evident in efficacy, now is reported as follows:
1. clinical data
98 routine patients are clinic case.Wherein, male 42 examples, women 56 examples; The oldest 68 years old, minimum 18 years old, average person's age 43 years old; The course of disease is the shortest 3 months, and is the longest 8 years.The patient all has clinical manifestations such as heavier palpitaition, precordialgia, fatigue and weak, responsive suspicious, anxiety or melancholy, irritated emotional, dizzy, insomnia, dreaminess.All patients get rid of other diseases all through the physics and chemistry inspection, are diagnosed as this disease.
2. methods of treatment
Get fire internal organ nourishing wine of the present invention, each 10-15ml, sub-service sooner or later is aided with psychological counseling simultaneously, and advises the patient to regulate feelings will, avoid pungent food and other irritable foods, and 30 days is 1 course of treatment, and all patients all take medicine and evaluate curative effect after I the course of treatment.
3. criterion of therapeutical effect
Recovery from illness: clinical symptom all disappears, and it is normal that the mental status is recovered, and follows up a case by regular visits to not recurrence more than 1 year, and take a turn for the better: clinical cardinal symptom disappears, and patient's subjective symptoms obviously alleviates, and is invalid: clinical symptom no change before and after the treatment.
4. treatment result
This is organized among the 98 routine patients, and 52 examples of fully recovering account for 53%; 43 examples that take a turn for the better account for 44%; Invalid 3 examples account for 3%, total effective rate 97%.
5. medical record for example
Zheng, woman 42 years old, first visit in July, 2004, cause was quarreled with other people in 3 years, annoyedly excessively fell ill.After ill, seek medical advice everywhere, though through the traditional Chinese and western medicine multi-treatment, curative effect is all not good enough.Multiple before nearly I month because of the pathogenic feelings in frightened back increase the weight of, mainly show as agitation, irritability, anxious; Meet environmental stimulus slightly, i.e. palpitation and uneasiness is had a guilty consicence in sense; Dizzy tinnitus, fatigue and weakness, dry mouth and throat, indigestion and loss of appetite being insomnia, dreaming often and waking easily.Suspect and day suffered from multiple disease, it is anxious to seek medical advice.Its tongue arteries and veins: red tongue with a little fluid, pulse condition is counted accurately.Examine and be psychoneurosis (type of hyperactivity of fire caused by deficiency of YIN).Give fire internal organ nourishing wine of the present invention, each I0ml, secondary clothes sooner or later.Take medicine after 1 course of treatment, clinical symptom all disappears, and it is normal that the mental status is recovered, and follows up a case by regular visits to I recurrence at the year end.
Conclusion:
Neurosis belongs to categories such as " melancholia " in motherland's medical science, " being insomnia ", " palpitaition ".This sick touching difficulty is more brought heavy mental burden to the patient.Western medical treatment is not good enough with curative effects such as tranquilizer, neuroregulators at present.The contriver thinks, the generation of this disease is many to be injured due to the relevant internal organs because of feelings will." heart is the big masters of the vital organs of the human body " the heart controlling mental and emotional activities ".So should be for the treatment of this disease, control the heart and be and effect a permanent cure based on the heart with fire internal organ nourishing wine of the present invention.Full side's bowl spares has logical, tonify without causing stagnation.Multiple medicine in the present invention's prescription share, and plays the effect of tranquilizing by nourishing the heart altogether, has reached good result of treatment.
Fire internal organ nourishing wine treatment female climacteric syndrome 40 examples of the present invention are analyzed
Female climacteric syndrome is meant before and after the menopausal women (45-55 year), because a series of vegetative nervous systems disorder syndromes appear in the ovarian function decline, its sickness rate is up to about 70%.The author treats 40 examples from year April in October, 2004 to 2005 with fire internal organ nourishing wine of the present invention, obtains satisfactory effect, now is summarized as follows:
1, clinical data
Observed 80 routine patients are clinic case, and wherein 40 examples are organized in treatment, 48.82 ± 2.82 years old age, 8 examples that the state of an illness is slight, moderate 22 examples, severe 10 examples; 1 year 8 example of the course of disease, 1-4 27 examples, 5 years 5 examples.Control group 40 examples, 49.08 ± 3.02 years old age, 7 examples that the state of an illness is slight, moderate 26 examples, severe 7 examples; 1 year 9 example of the course of disease, 1-4 25 examples, 5 years 6 examples.The equal no difference of science of statistics in aspect such as severity extent, the course of disease has comparability.
Case definition Western medicine diagnose standard is by " new Chinese medicine clinical study governing principle " female climacteric syndrome Case definition [1]Work out.1. the age is at 45-55 between year; 2. symptom is except that menstruation imbalance, have warm, the sweating classical symptom, or with irritated irritability, palpitation and insomnia, hypomnesis, emotion-thought abnormal, fluctuation of blood pressure etc.; 3. endocrine hormone detects: serum oestrogenic hormon (E 2) level decline, ovarian follicle oestrogenic hormon (FSH), lutropin (LH) level raise.The tcm diagnosis standard is by all disease interior-heat caused by deficiency of YIN before and after " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " menopause, pathogenic fire derived from stagnation of liver-QI Case definition [2]Work out.Promptly warm flushing, the hectic fever sweating, vexed not peaceful, insomnia and dreamful sleep, being irritable and getting angry easily, dizziness and tinnitus, the red few tongue of tongue, stringy,thready and rapid pulse.Get rid of the case standard, the age is less than 45 years old, or greater than 55 years old person, bilateral ovaries excision, ovarian tumor, premature ovarian failure person; Merge endocrinopathy, cardiovascular and cerebrovascular diseases, liver kidney and disease of hematopoietic system, mental patient, the high blood disease of primary, chronic anaemia person; Once obeyed the sexual hormoue patient in 3 months.
2. methods of treatment
The treatment group, the each 10ml of fire internal organ nourishing wine of the present invention, every day 3 times, 30 days is 1 course of treatment.Control group gives GENGNIAN NINGXIN JIAONANG (Kweiyang medicine company production in new day), and each 5, every day 3 times, 30 days was 1 course of treatment.Observed and recorded clinical symptom and serum E before and after the each patient treats 2, FSH, LH assay (adopt the radioimmunology analysis method, reagent adopts Shenzhen La Erwen biotechnology company limited to produce test kit), after finishing the course of treatment, learn by statistics and handle.
3. treatment result
Efficacy assessment standard: with reference to " new Chinese medicine clinical study governing principle " female climacteric syndrome curative effect determinate standard [1]Produce effects: the symptom score difference before and after the treatment equals 1, E with the ratio for the treatment of preceding symptom score 2Raise, FSH and LH descend; Effectively: the ratio of symptom score before the symptom score difference before and after the treatment and the treatment is greater than 2/3, E 2Raise, FSH and LH descend; Take a turn for the better: the ratio of the symptom score before symptom score difference before and after the treatment and the treatment between 1/3-2/3, E 2, FSH and LH do not have pharynx and show and descend; Invalid: the ratio of symptom score before the symptom score difference before and after the treatment and the treatment is less than 1/3, E 2Descend or no change FSH and LH rising or no change.
Symptom score: with reference to Knpperman [3]Involution syndrome symptom evaluation criteria is formulated in scoring, carries out quantization assessment with light and heavy degree and result of treatment to the state of an illness.And to the juice of uniting of symptom score and symptom score and symptom total points before and after the treatment.
E before and after the treatment 2, FSH, LH variation treatment back and treatment before relatively, two groups of E 2Remarkable rising is all arranged, and (P＜0.05=year decline is all arranged after FSH, the LHI treatment, but comparing difference does not have significance before and after the treatment, sees Table 1.
E2, FSH, LH situation (x ± s) relatively before and after the treatment of table 1 liang group
Grouping The example number E 2(pg/ml) PSH(miu/ml) LH(miu/ml)
The treatment group Treat preceding 40 140.53± 56.61±41.4 83.53±34.83
Treatment back 40 196.32±156.96 * 51.29±43.06 70.05±29.09
Control group Treat preceding 40 146.88±143.27 55.21±34.65 80.37±34.57
Treatment back 40 180.76±137.57 * 52.79±36.16 62.21±31.01
Annotate: relatively preceding with treatment, P＜0.05.
Symptom score all significantly reduced after the doing well,improving situation compared two groups of treatments before and after two groups of treatments, with treatment preceding relatively (P＜0.05), compared with control group, and the treatment group obviously is better than control group (P＜0.05), sees Table 2.
A symptom score changes relatively (X ± S) before and after the treatment of table 2 liang group
Group The example number Symptom score
The treatment group Before the treatment 40 36.24±8.13
After the treatment 40 11.23±3.40 **△
Control group Before the treatment 40 35.19±8.01
After the treatment 40 21.86±6.21 *
Annotate: relatively preceding with the treatment of this group, △ P＜0.05 is compared in P＜0.05 after P＜0.01gn treatment of control group.Two groups of curative effects relatively treatment are organized 40 examples, produce effects 8 examples, effective 21 examples, 7 examples that take a turn for the better, effective 16 examples.Total effective rate 90%.Control group 40 examples, produce effects 5 examples, effective 16 examples, 11 examples that take a turn for the better, invalid 8 examples.Total effective rate 77.5%.The treatment group is obviously in control group (P＜0.05=.
4. case introduction
Poplar, the woman, 51 years old, first visit on October 12 in 2004, amenorrhoea 1 year, nearly half a year, it is flushing hectic fever to occur, and sweating increased the weight of individual month.Existing card: hectic fever, flushing sweating battle array are done, and You Yichen wakes up for very, and be forgetful, lose the people, dreaminess, being irritable and getting angry easily, even had palpitation, and the sad desire of happiness device, tongue limit point is red, white and thin fur, stringy and thready pulse.
Laboratory examination: E 2207Miu/ml LH 69Miu/ml HSH 57miu/ml.It is insufficiency of the spleen that Chinese medical discrimination belongs to conscience, depressed liver and heat transmission.Controlling should be nourishing Yin and clearing heat, and tonic wine of the present invention is adopted in tranquilizing by nourishing the heart, and each 10～15ml took for two weeks every day 3 times, and hectic fever sweating, insomnia and dreamful sleep all subtract, and continues two weeks of clothes symptom again by commercial weight.Laboratory examination: E2207 miu/ml LH69miu/ml FSH69 miu/ml FSH46miu/ml.
Conclusion:
Female climacteric syndrome at present, thinks mainly owing to hypo-ovaria that the incretion balance imbalance causes due to the disorder of vegetative nerve merit, is a kind of performance that woman's enters aging state.(Jinkui Yaolue) cloud: " consumptive disease with restlessness insomnia, suanzaoren decoction master it " " woman is from hysteria, and susceptible to sorrow and being about to weep is done if any gods, and frequent yawning is stretched, GANMAI DAZAO TANG master it." Spina Date Seed is sweet flat in the side, nourishing the liver tranquillizing by calming the heart, arrest sweating.(Mingyi Bielu) cloud: main vexatious insomnia ... abnormal sweating ... the benefit irritability, hard dish bone helps cloudy gas, makes us fertile strong.Radix polygonati officinalis is sweet cold, nourishing Yin and falling fire, and (property of medicine opinion) meaning cures mainly vexed hot-tempered vexed ...The two medicines yin-nourishing tonifying liver that is harmonious is monarch drug in a prescription altogether.Modern pharmacological research, Spina Date Seed, skunk bush all have sedative-hypnotic effect; Mulberry chess, date regulating YIN and YANG transfer battalion to defend, and the hidroschesis that promotes the production of body fluid, bushing spleen are with nourishing the liver, and son can make female real, is ministerial drug altogether; The Glossy Privet Fruit clearing away liver-fire; The Tuber Fleeceflower Root regulating blood condition is soothing the liver, and astringe yin, hidroschesis are adjutant altogether.It is main that liver is transferred in full side's yin-nourishing, tranquillizing by calming the heart is auxilliary, all adopts said medicine in the tonic wine prescription of the present invention, makes by specific compatibility relationship, with the starting stage in the female aging process be that the interpretation of the cause, onset and process of an illness of pathologic basis adapts with the liver, be the active drug of treatment female climacteric syndrome.
By above-mentioned clinical result as can be seen, tonic wine of the present invention being widely used clinically, remarkable to a lot of curative effect of disease, but traditional tonic wine is cooked the wine base because of the high wines that adopt more, goes so decrease to hold concurrently with its benefit, and each is variant because of people's physique again, the somebody holds a lot of liquor, some people is unequal to capacity for liquor, and the somebody never touches wine, so the wine therapy is not to be fit to all patients.And because of treatment usually is the mixed solution of wine and medicine with wine, thus promptly be that magnanimity person also can not can drink to full as the usual method of drinking, otherwise not only do not reach result of treatment, also can cause the alcohol drug intoxication.In general, high spirit subject range is narrow, and suitable those is held a lot of liquor or patients such as arthralgia, wound take, and also is suitable for external application.Be used to outward cure the wound or part when embrocating, concentration can be between 40%～60%.The present invention can adopt low alcohol or the then suitable more patients of fermented glutinous rice such as yellow rice wine and fruit wine, and stomach trouble, cardiovascular system diseases, women, old man and the patient that has a delicate constitution are all drinkable.
Wine therapy of the present invention is applicable to following patient's: 1. because of the limited disease of limbs joint pain, joint stuffiness, functional activity due to arthralgia due to wind-cold-dampness pathogen BI syndrome, strain, hyperosteogeny, the frostbite etc.; 2. because of the blood stasis patient due to the external force damage; 3. the obstruction of qi in the chest patient due to the coronary heart disease, the embolism pathology of cardiovascular systems; 4. not all right, the underbelly pain of lochia due to women's extravasated blood in postpartum is accumulated; 5. dysmenorrhoea, menoxenia due to unmarried girl's extravasated blood; 6. the weak patient of men and women's sexual function; 7. the old man and the patient that has a delicate constitution; 8. various dermatosis patients.
The careful wine therapy of using is then forbidden or needed to following patient's:
1. having serious liver, renal insufficiency patient to avoid drinks; 2. the profuse bleeding patient avoids and drinks; 3. the wine allergy sufferers is avoided clothes; 4. some chemical ingredients can be dissolved in the wine in the Western medicine, then chemical reaction takes place and influences drug effect with clothes with wine, or make it that toxic side effects take place, so do not drink during the clothes Western medicine; 5. acute infectious disease or high hot patient should not drink high wine; 6. the mental patient should not drink high wine; 7. Chinese medical discrimination belongs to the syndrome of hyperactivity of fire due to deficiency of YIN type, and disease sees that mouthful thousand tongues are dry, dysphoria in chestpalms-soles, the red night sweat person of cheekbone should not take high wine; 8. the high hot season of dog days should not be drunk high wine; 9. patients with gastric disease and should not drink high wine on an empty stomach avoids excessive stomach is produced of alcohol to stimulate and the infringement stomach mucous membrane.

Claims (9)

1, a kind of fire internal organ nourishing wine is characterized in that: this tonic wine is that the medicinal raw material that adds following prescription in per 5～10 kilograms of wine makes: Radix Codonopsis 15～50g, Cordyceps sinensis 10～30g, Glossy Privet Fruit 15～50g, Radix Panacis Quinquefolii 10～50g, glossy ganoderma 15～60g, the tuber of dwarf lilyturf 10～30g, radix polygonati officinalis 15～30g, Radix Astragali Preparata 15～50g, hawthorn 10～30g, baked polygonum capitatum 15～50g, cultivated land 15～50g, wolfberry fruit 30～250g, Fructus Mori 30～300g, longan aril 70～300g, semen juglandis 15～100g, shizandra berry 10～50g, skunk bush 10～50g, date 20～100g, Formica fusca 6～50g, Herba Cistanches 10～100g.
2, according to the fire internal organ nourishing wine described in the claim 1, it is characterized in that: it is a kind of in 32 °～60 ° liquor or the rice wine below 28 ° and fruit wine, the grape wine that described wine is selected alcoholic strength for use.
3, a kind of preparation technology of fire internal organ nourishing wine is characterized in that: it is undertaken by following particular step:
A. get each medicinal raw material by the described prescription of claim 1;
B. each medicinal raw material is carried out pre-treatment;
C. the soup that step b is obtained after to the medicinal raw material pre-treatment mixes and blends;
D. mixing is blent and promptly get tonic wine of the present invention after back soup and wine adopt infuse method, brew method or percolation to handle.
4, according to the preparation technology of the fire internal organ nourishing wine described in the claim 3, it is characterized in that: above-mentioned steps b carries out pre-treatment to medicinal raw material and is: Cordyceps sinensis and Radix Panacis Quinquefolii → obtain after soaking in Chinese liquor → heat treated → clarification respectively Cordyceps sinensis liquid and american ginseng liquid; Hawthorn, wolfberry fruit, shizandra berry, date, walnut → processing are after obtain soup after soaking in Chinese liquor → clarification; Formica fusca and other Chinese medicinal materials → through after selected, the removal of impurity → soak, obtain soup after lixiviate → filtration → clarification; Four kinds of soups of above-mentioned gained are mixed to blend promptly get medicinal raw material pre-treatment soup.
5, according to the preparation technology of the fire internal organ nourishing wine described in the claim 3, it is characterized in that: above-mentioned pre-treatment to each medicinal raw material is: the Radix Astragali is processed with honey, and 1.5 jin of sweet big guns of per 10 jin of usefulness are processed, and stirs evenly; Cultivated land adopts the dried rhizome of rehmannia to stir with wine, and 10 jin add 1 jin of yellow rice wine and stir; Baked polygonum capitatum adds yellow rice wine with Radix Polygoni Multiflori and stirs, and 10 jin add 1 jin of yellow rice wine; The preparation of Radix Panacis Quinquefolii extractive juice: select for use total saponin content greater than 8% high-quality Radix Panacis Quinquefolii, after cleaning removal impurity, be broken into small-particle with pulverizer less than 5mm, to increase its surface-area, improve leaching efficiency, ginseng granules after the fragmentation is quantitatively dropped in the alcohol reflux lixiviate jar, the concentration that adds 10 times of weight is 85% ethanolic soln, under 45 ℃ temperature, soaked 72 hours, emit pure liquid filtration then and obtain filtrate I, repeat again to soak once, filter and obtain filtrate II, the fresh ethanol solution that adds 8 times of weight in the ginseng slag after twice immersion filtration was once more refluxed 2.5 hours, temperature≤80 ℃, repetitive operation twice is collected respectively and is obtained filtrate II I and IV, above-mentioned 4 kinds of filtrates of collecting are merged, and underpressure distillation recovery ethanol, the nothing alcohol vat liquor of gained carries out vacuum concentration under 62 ℃ condition, be concentrated into 1/2 volume, in gained genseng vat liquor, add 6% cycloheptaamylose, utilize dextrin the in addition embedding and alleviate its bitter taste of ginsenoside composition to minimum degree; Matrimony vine is handled: remove impurity, cleaning, wolfberry fruit is steeped the cell tissue of 2h with softening matrimony vine with 40 ℃ water logging, carry out crushing and beating with hollander then, the gained slurries add the lixiviate 3 hours of purifying waste water under 70～80 ℃ temperature of 10 times of weight, remove by filter residue, gained matrimony vine juice is through vacuum concentration to 1/2 volume, and the cooling back is standby; The pre-treatment of walnut kernel: select completely filled fruit, no worm, do not have the walnut kernel that goes mouldy, remove the kind skin of walnut kernel, NaOH solution with 2.0 ℃, be heated to 95 ℃, walnut kernel immersed in the solution soaked about 1 minute, take out and remove kernel kind skin and remaining NaOH with flushing with clean water, the walnut kernel after the peeling was with 35～40 ℃ warm water soaking 1.5-2 hour, the walnut kernel histocyte is fully expanded moisten, soften, improve the protein leaching yield; The preparation of haw raw material: select lovely luster for use, fully ripe, full, the Fructus Crataegi of no disease and pest, remove impurity, clean up, to put in order fruit with discaling roll formula pulverizer or manual type and be ground into 4～5 fritters, then with in the purifying waste water of 2 times of weight of hawthorn fruit piece input, feeding is steam heated to 85～95 ℃, and be incubated 30 minutes and soften processing, making the hawthorn histocyte fully expand to moisten softens, improve the leaching yield of active substance, hawthorn fruit piece after softening and softening water are sent into hollander together and are carried out crushing and beating, the gained slurries carry out miniaturization by colloidal mill again to be handled, refinement degree≤5 μ m, and gained haw pulp Normal juice cooling back is standby; The preparation of red date, Radix Astragali vat liquor: select for use lovely luster, fully ripe, do not have go mouldy, the date of no insect pest, the Radix Astragali be raw material, after removing impurity, clean up with clear water, add purifying waste water of 3 times of weight then, put into steam cooker, feed and be steam heated to 90～95 ℃, add a cover insulation 30 minutes, after the filtration vat liquor II, twice vat liquor merged and be cooled to after the room temperature standby; Formica fusca: the select fine seed strains ant, require the polyrhachis of drying, inclusion-free, free from extraneous odour, no pesticidal contamination all, adopt cold-maceration, Formica fusca and Chinese medicinal materials all soaked 15～20 days at normal temperatures with alcohol, and lixiviate is filtered, recovered alcohol is drawn supernatant liquor then, and it is standby to mix clarification; Walnut: select for use complete, totally, it is pale yellow to amber that the kernel that free from insect pests is gone mouldy is, the washing walnut of kernel content 〉=55% or common walnut, the iron walnut is a raw material, adopt the alcohol extracting technology of fat melting, fully lixiviate goes out its effective nutritive ingredient, in allocation process, call in an amount of Fructus Vitis viniferae wine base and natural medicinal flavours: juice is got in the longan aril fragmentation: peeling, after the stoning, with the method for Mechanical Crushing with pulp crushing, press extracting juice with expeller again, for preventing the oxidation stain of microbiological contamination and fruit juice, add the potassium metabisulfite of 120mg/kg at pulp.
6, according to the preparation technology of the fire internal organ nourishing wine described in the claim 4, it is characterized in that: the preparation of above-mentioned Cordyceps sinensis liquid: get the bright product of Cordyceps sinensis, add end wine in 1: 300 ratio, the room temperature lixiviate is 7～10 days in the lixiviate jar, filter, filter residue adds end wine, lixiviate 5～7 days in 1: 200 ratio, filter, merge the twice golden yellow extremely pale brown look filtrate of gained and promptly get Cordyceps sinensis liquid; The preparation of lucidum liquid: the glossy ganoderma dry product is broken for the fritter about 1cm, adds end wine in 1: 200 ratio, and lixiviate is 15 days in the lixiviate jar, filters, and filter residue adds steeping in wine by 1: 100 ratio and carries 10 days, and filtration merges twice filtrate promptly; The preparation of herb liquid: in 5: 3: 3: 6 ratio takes by weighing wolfberry fruit, Radix Codonopsis, Glossy Privet Fruit, the mixing tuber of dwarf lilyturf respectively, add softening water in 1: 30 ratio, put in the lixiviate jar, in 55～65 ℃ of insulation lixiviates 10～16 hours, filter, filter residue added softening water in 1: 10 ratio, in 75～85 ℃ of insulation lixiviates 4～6 hours, filter, merging filtrate promptly; Above-mentioned gained soup is mixed, blends: in 1: 1: 1: 1 ratio with Cordyceps sinensis liquid, lucidum liquid, herb liquid, liquid glucose in mixing tank thorough mixing, convert equal.
7, according to the preparation technology of the fire internal organ nourishing wine described in the claim 3, it is characterized in that: described infuse method adopts cold-maceration: after the consumption medicinal raw material pre-treatment of will filling a prescription, in the input container, be blended into high quality liquor or yellow rice wine by ratio, sealing is soaked, often jolting or stir medicine between soak period, stored 1～180 day, the abundant stripping of effective constituent in the medicine, the property of medicine and alcoholic strength fully merge, and wine juice is leached promptly.
8, according to the preparation technology of the fire internal organ nourishing wine described in the claim 3, it is characterized in that: described brew method, with the formula ratio medicinal raw material clean drain after, through pre-treatment shooting soup, will mix thoroughly with the steamed sticky rice meal behind the medical filtration, treat that its back that cools off adds distiller's yeast, or after medicine smashed to pieces, directly with glutinous rice with boiling, in container, it was fermented 1～180 day by making the sweet wine method, to wine flavour when sweet, promptly.
9, according to the preparation technology of the fire internal organ nourishing wine described in the claim 3, it is characterized in that: described percolation is that the medicinal raw material of will fill a prescription is cut into fragment or smashes into thick end, after the moistening expansion of liquor, pack in the percolator, be blended into liquor and carry out diacolation, the composition of medicine is diffused in the diacolation process in the wine promptly.
CNB2006100456202A 2006-01-09 2006-01-09 Fire internal organ nourishing wine and its preparation technology Expired - Fee Related CN100374538C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CNB2006100456202A CN100374538C (en) 2006-01-09 2006-01-09 Fire internal organ nourishing wine and its preparation technology

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB2006100456202A CN100374538C (en) 2006-01-09 2006-01-09 Fire internal organ nourishing wine and its preparation technology

Publications (2)

Publication Number Publication Date
CN1824763A true CN1824763A (en) 2006-08-30
CN100374538C CN100374538C (en) 2008-03-12

Family

ID=36935605

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2006100456202A Expired - Fee Related CN100374538C (en) 2006-01-09 2006-01-09 Fire internal organ nourishing wine and its preparation technology

Country Status (1)

Country Link
CN (1) CN100374538C (en)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101705172B (en) * 2009-10-26 2012-03-28 宜昌楚汉风生物科技有限公司 Lucid Ganoderma nutritious wine and preparation method thereof
CN101617825B (en) * 2009-08-07 2012-04-25 李发 Preparation method of lucid ganoderma health-care wine
CN102851187A (en) * 2012-08-15 2013-01-02 黄金洪 Black fruit health care brewed liquor and production process thereof
CN102048151B (en) * 2009-11-03 2013-03-27 湖北中烟工业有限责任公司 Health-care capsules with body and qi-nourishing function and preparation method thereof
CN103131609A (en) * 2013-02-28 2013-06-05 徐州古彭酒业有限公司 Men's health preserving and life lengthening wine and its preparation method
CN103232916A (en) * 2013-03-28 2013-08-07 陆开云 Fragrant solomonseal rhizome-containing tea rice wine and preparation method thereof
CN103451067A (en) * 2012-05-28 2013-12-18 肖旭 Anti-fatigue healthcare medicinal liquor
CN103602550A (en) * 2013-11-26 2014-02-26 青岛嘉瑞生物技术有限公司 Compound fermentation type cornus officinalis pulp health-care wine and production method thereof
CN103695265A (en) * 2013-11-28 2014-04-02 安徽明龙酒业有限公司 Wine containing coix seed and Cordyceps sinensis
CN104988006A (en) * 2015-06-30 2015-10-21 柳州仙鼎酒厂 Production method for health-care medicinal liquor containing radix adenophorae
CN105213896A (en) * 2015-10-28 2016-01-06 王继荣 Cordyceps toxin expelling keeps fit liquid and preparation method thereof
CN105238649A (en) * 2015-08-13 2016-01-13 合肥众月健康科技有限公司 Qi-invigorating and soothing pea rice wine and preparation method thereof
CN105497140A (en) * 2015-12-02 2016-04-20 周文军 Traditional Chinese medicine composition with health function, preparation method and health traditional Chinese medicine liquor
CN105820910A (en) * 2016-05-05 2016-08-03 安徽味多多餐饮管理有限公司 Iron-rich blueberry healthcare wine and preparing method thereof
CN106281916A (en) * 2016-08-18 2017-01-04 李新民 A kind of Laiyang pear tonic wine and preparation technology thereof
CN109266486A (en) * 2018-10-17 2019-01-25 安徽省福宁米业有限公司 A kind of blood-enriching face-nourishing rice wine and preparation method thereof
CN110044895A (en) * 2019-04-25 2019-07-23 绵阳师范学院 The leaching method and content assaying method of microelement in silky ant wine
CN111662797A (en) * 2020-05-30 2020-09-15 福建柘参生物科技股份有限公司 Formula of three-ginseng health wine and brewing and soaking method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1052879C (en) * 1996-02-13 2000-05-31 广西壮族自治区药物研究所 Dragon wine with composition containing Chinese medicines, e.g., centipede
CN1166984A (en) * 1997-03-21 1997-12-10 梅珍珠 Health care wine and preparation method
CN1424061A (en) * 2001-12-13 2003-06-18 孙家盛 Spirit for restoring menstrual flow
CN1715393A (en) * 2004-07-02 2006-01-04 汪贤兔 Composition for preparing health wine and health wine

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101617825B (en) * 2009-08-07 2012-04-25 李发 Preparation method of lucid ganoderma health-care wine
CN101705172B (en) * 2009-10-26 2012-03-28 宜昌楚汉风生物科技有限公司 Lucid Ganoderma nutritious wine and preparation method thereof
CN102048151B (en) * 2009-11-03 2013-03-27 湖北中烟工业有限责任公司 Health-care capsules with body and qi-nourishing function and preparation method thereof
CN103451067B (en) * 2012-05-28 2014-08-13 肖旭 Anti-fatigue healthcare medicinal liquor
CN103451067A (en) * 2012-05-28 2013-12-18 肖旭 Anti-fatigue healthcare medicinal liquor
CN102851187A (en) * 2012-08-15 2013-01-02 黄金洪 Black fruit health care brewed liquor and production process thereof
CN103131609A (en) * 2013-02-28 2013-06-05 徐州古彭酒业有限公司 Men's health preserving and life lengthening wine and its preparation method
CN103232916A (en) * 2013-03-28 2013-08-07 陆开云 Fragrant solomonseal rhizome-containing tea rice wine and preparation method thereof
CN103232916B (en) * 2013-03-28 2014-02-19 陆开云 Fragrant solomonseal rhizome-containing tea rice wine and preparation method thereof
CN103602550A (en) * 2013-11-26 2014-02-26 青岛嘉瑞生物技术有限公司 Compound fermentation type cornus officinalis pulp health-care wine and production method thereof
CN103695265B (en) * 2013-11-28 2016-01-20 安徽明龙酒业有限公司 A kind of heart of a lotus seed benevolence cordyceps militaris liquor
CN103695265A (en) * 2013-11-28 2014-04-02 安徽明龙酒业有限公司 Wine containing coix seed and Cordyceps sinensis
CN104988006A (en) * 2015-06-30 2015-10-21 柳州仙鼎酒厂 Production method for health-care medicinal liquor containing radix adenophorae
CN105238649A (en) * 2015-08-13 2016-01-13 合肥众月健康科技有限公司 Qi-invigorating and soothing pea rice wine and preparation method thereof
CN105213896A (en) * 2015-10-28 2016-01-06 王继荣 Cordyceps toxin expelling keeps fit liquid and preparation method thereof
CN105497140A (en) * 2015-12-02 2016-04-20 周文军 Traditional Chinese medicine composition with health function, preparation method and health traditional Chinese medicine liquor
CN105820910A (en) * 2016-05-05 2016-08-03 安徽味多多餐饮管理有限公司 Iron-rich blueberry healthcare wine and preparing method thereof
CN106281916A (en) * 2016-08-18 2017-01-04 李新民 A kind of Laiyang pear tonic wine and preparation technology thereof
CN109266486A (en) * 2018-10-17 2019-01-25 安徽省福宁米业有限公司 A kind of blood-enriching face-nourishing rice wine and preparation method thereof
CN110044895A (en) * 2019-04-25 2019-07-23 绵阳师范学院 The leaching method and content assaying method of microelement in silky ant wine
CN111662797A (en) * 2020-05-30 2020-09-15 福建柘参生物科技股份有限公司 Formula of three-ginseng health wine and brewing and soaking method thereof

Also Published As

Publication number Publication date
CN100374538C (en) 2008-03-12

Similar Documents

Publication Publication Date Title
CN1824763A (en) Fire internal organ nourishing wine and its preparation technology
CN102344876B (en) Nine-medicine Shengzi red fruit wine and preparation method thereof
CN1820618A (en) Health preserving liver protection tea and its preparing method
CN108904563B (en) Processing method and application of whole-plant ginseng raw stock
CN109646663A (en) A kind of Chinese medicine distillers yeast and preparation process
CN114042126B (en) Traditional Chinese medicine composition for ascending clear, eliminating turbid, promoting diuresis, benefiting qi, losing weight and reducing fat and preparation method thereof
CN105770420A (en) Chinese herbal medicine with anti-cancer effect and preparation method thereof
CN106177053A (en) A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Pericarpium Citri Reticulatae
CN101780242B (en) Health or medicine composition and preparation method and application thereof
CN103155985A (en) Rhizoma polygonati nutrition powder and preparation method thereof
CN106177477A (en) A kind of health composition for blood sugar lowering, blood fat reducing and blood pressure lowering
CN1522754A (en) Extraction of antiviral immune matter for curing sexual disorder and its formulation
CN104223297A (en) Aging-delaying health schisandra chinensis oral solution and preparation method thereof
CN101036722A (en) Health-caring food for easing and improving climacteric Syndrome of men and the preparation thereof
CN1232267C (en) Compound plant medicine and its application
CN1232270C (en) Medicinal composition for treating liver cancer and pancreatic cancer and its preparing method
CN100337655C (en) Medicine preparation for preventing and treating allergic rhinitis and compliance rhinitis
CN108815391A (en) A kind of preparation process of double Herba Dendrobii extracts of liver damage protection function
CN106177479A (en) A kind of Hyperglycemic health care compositions comprising Herba Dendrobii and Rhizoma Polygonati Odorati
CN104771595B (en) A kind of Chinese medicine composition of strengthen immunity and preparation method thereof
CN107812115A (en) A kind of Chinese medicine composition for treating diabetes
CN1931233A (en) Medicine composition of red sage and epimedium for treating cardiac and cerebral vascular diseases
CN101040934A (en) Medicine compound made of haw leaf and rhodiola
CN101049355A (en) Composition of medication prepared from safflower and leaves of hawthorn
CN108096289A (en) A kind of antrodia capsule formula and production method

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20080312

Termination date: 20220109

CF01 Termination of patent right due to non-payment of annual fee