CN1559572A - Compound Sanhuang powder - Google Patents
Compound Sanhuang powder Download PDFInfo
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- CN1559572A CN1559572A CNA2004100219759A CN200410021975A CN1559572A CN 1559572 A CN1559572 A CN 1559572A CN A2004100219759 A CNA2004100219759 A CN A2004100219759A CN 200410021975 A CN200410021975 A CN 200410021975A CN 1559572 A CN1559572 A CN 1559572A
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- radix
- herba
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- sanhuangsan
- cordyceps
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Abstract
A Chinese medicine for treating AIDS and cancers and suppressing HIV, cancer cell, and DNA (or RNA) viruses is prepared from 16 Chinese-medicinal materials including astragalus root, liquorice root, Chinese angelica root, cordyceps, etc.
Description
Technical field
The present invention is a kind of treatment acquired immune deficiency syndrome (AIDS) and anti-cancer drug preparation with the crude drug preparation.
Background technology
Acquired immune deficiency syndrome (AIDS) comprises that AIDSinfected patient and all kinds of malignant tumor, cancer are the diseases of serious threat human health.Still the specific drug that does not have at present the treatment acquired immune deficiency syndrome (AIDS); The main means that are used for the treatment of cancer are chemotherapy, the chemotherapeutics overwhelming majority of clinical practice makes toxic and side effects such as the patient feels sick, vomiting, leukopenia, bone marrow depression, influence patient's body health, also limited the clinical practice of chemotherapeutics greatly.Therefore, seek high activity, nontoxic or hypotoxic pure natural treatment acquired immune deficiency syndrome (AIDS) and cancer therapy drug become an important topic of new drug research.
Summary of the invention
The invention provides a kind of complex prescription SANHUANGSAN, has eliminating toxic substances to remove stasis, set upright and get rid of evils, strengthen the effect of immune function of human body, be to be applicable to aids patient, comprise AIDSinfected patient and all kinds of cancer patient, suppress HIV, malignant cell and other DNA, RNA viruses, the medicine preparation of promote people body immunity function.
Pure Chinese medicinal preparation provided by the invention shows through pharmacodynamics and clinical observation treatment effect: a, it has inhibitory action to HIV, malignant cell; B, it has obvious potentiation to animal and immune function of human body.It is by environment in improvement, adjusting and the balance body system, promote body system performance " creation certainly ", " selfreparing ", " self-regulation ", " defence certainly ", " self-organizing " behavior and be tending towards perfect in mesomeric mode on the whole, thereby resist and treat above-mentioned disease.
Complex prescription SANHUANGSAN provided by the invention is made by following method: Cortex Phellodendri 18g~20.9g, Radix Astragali 28g~33g, Radix Scutellariae 28g~32g, Semen Cuscutae 28g~33g, Rhizoma Atractylodis Macrocephalae 19g~25g, Herba Hedyotidis Diffusae 30g~45g, Radix Pulsatillae 25g~30g, Radix Bupleuri 15g~18g, Herba Taraxaci 16g~21g, Radix Saposhnikoviae 25g~30g, Radix Glycyrrhizae 16g~19g, Radix Angelicae Sinensis 28g~34g, Cordyceps 37g~46g, Rhizoma Curcumae 19g~23g, Cortex Moutan 17g~22g, Herba Violae 27g~32g amount to 16 flavors
A, the Cortex Phellodendri with in the above prescription, the Radix Astragali, Radix Scutellariae, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Herba Violae 7 flavors add water and are warming up to 100 degree water and carry 1 hour behind the selecting crude drugs with winnower decontamination, continuous three extraction backs with the dried paste of extracting liquid filtering simmer down to, are chilled to room temperature and pulverize under 20 ℃;
B, the Herba Hedyotidis Diffusae with in the above prescription, the Radix Pulsatillae, Radix Bupleuri, Herba Taraxaci, Radix Saposhnikoviae, Radix Glycyrrhizae, Cordyceps, Rhizoma Curcumae, Cortex Moutan 9 flavors are made the meticulous powder of 4~10 μ m behind the ultra micro breaking cellular wall, manufactured goods keep moisture 4~9%;
C, two steps of a, b are made thing mix and add 0.4~1.5 times of pharmaceutic adjuvant, evenly stir and make granule dosage form or capsule after vacuum spray drying is handled.
Described preparation method can adopt supersonic speed four-way molecule head-on collision technology to carry out production and processing, concrete manufacture technology link is: coarse pulverization, the sieve that shakes, selecting crude drugs with winnower, ultra-fine, breaking cellular wall, ultra micro, handle through this kind ultramicrotechnique, drug cell molecule breaking cellular wall, diameter of aspirin particle is 5 μ m~10 μ m, and manufactured goods keep moisture 4~9%.
Described best proportioning is: Cortex Phellodendri 20.9g, Radix Astragali 33g, Radix Scutellariae 31.9g, Semen Cuscutae 33g, Rhizoma Atractylodis Macrocephalae 24.2g, Herba Hedyotidis Diffusae 39.6g, Radix Pulsatillae 28.6g, Radix Bupleuri 17.6g, Herba Taraxaci 19.8g, Radix Saposhnikoviae 28.6g, Radix Glycyrrhizae 17.6g, Radix Angelicae Sinensis 33g, Cordyceps 44g, Rhizoma Curcumae 22g, Cortex Moutan 19.8g, Herba Violae 30.8g.
Above-mentioned peroral dosage form can be granule, capsule, tablet or syrup, oral liquid.
Above-mentioned 16 flavor Chinese crude drugs, net weight 444.4 grams, every flavor is prepared with 6~18 times of dose-effect relationships, adds medical accessory and makes 1000 bags of granule dosage forms or 1000 seed lac wafers.
The specific embodiment:
1. complex prescription SANHUANGSAN granule therapy acquired immune deficiency syndrome (AIDS) and AIDS related complex 11 examples.Wherein 7 routine remissions, 4 routine HIV carrying capacity decline 〉=0.5Log, 3 routine CD4+T lymphocytes rise 〉=20%, effective percentage 63.63%.
2. carry out the human body phase ii clinical trial in the somewhere, Yunnan, with complex prescription SANHUANGSAN granule therapy acquired immune deficiency syndrome (AIDS) (AIDS) and AIDS related complex (ARC) 41 examples, matched group 39 examples are used placebo, and two groups all give Western medicine symptomatic treatment and nutritional support.Before the treatment, through asking treasure, health check-up, conventional blood cell analysis, hepatic and renal function inspection, CD3+CD4+CD8+T lymphocyte count (flow cytometry), HIV carrying capacity mensuration<test kit: AMPLICOR HIV-IMONNITOR TM Test Version1.5 (Roche Diagnostics, Branchburg, NJ08876 USA)>, checks such as X line rabat, B ultrasonic and electrocardiogram, find that some cases clinical symptom disappearance or obviously improvements, spiritual appetite improvement, weight increase, opportunistic infection control; Lymphocyte absolute counting, CD4+T lymphocyte rising 〉=20%, HIV carrying capacity decline 〉=0.5Log.Treatment group effective percentage 63.42% is compared with matched group, and obvious significant difference P<0.05 is arranged.
After the drug withdrawal 5 months, organize among the 41 routine patients, taken out 20 example checks at random, 〉=25% 6 examples of CD4+T lymphocyte rising as a result, HIV carrying capacity decline 〉=0.5Log person 5 examples, HIV carrying capacity decline 〉=0.4-0.49Log person 3 examples in treatment.Drug withdrawal still kept 56.58% effective percentage in 5 months.
Claims (5)
1, complex prescription SANHUANGSAN, it is characterized in that being made by following method: Cortex Phellodendri 18g~20.9g, Radix Astragali 28g~33g, Radix Scutellariae 28g~32g, Semen Cuscutae 28g~33g, Rhizoma Atractylodis Macrocephalae 19g~25g, Herba Hedyotidis Diffusae 30g~45g, Radix Pulsatillae 25g~30g, Radix Bupleuri 15g~18g, Herba Taraxaci 16g~21g, Radix Saposhnikoviae 25g~30g, Radix Glycyrrhizae 16g~19g, Radix Angelicae Sinensis 28g~34g, Cordyceps 37g~46g, Rhizoma Curcumae 19g~23g, Cortex Moutan 17g~22g, Herba Violae 27g~32g amount to 16 flavors
A, the Cortex Phellodendri with in the above prescription, the Radix Astragali, Radix Scutellariae, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Herba Violae 7 flavors add water and are warming up to 100 degree water and carry 1 hour behind the selecting crude drugs with winnower decontamination, after continuous three extractions, under 20 ℃,, be chilled to room temperature and pulverize the dried paste of extracting liquid filtering simmer down to;
B, the Herba Hedyotidis Diffusae with in the above prescription, the Radix Pulsatillae, Radix Bupleuri, Herba Taraxaci, Radix Saposhnikoviae, Radix Glycyrrhizae, Cordyceps, Rhizoma Curcumae, Cortex Moutan 9 flavors are made the meticulous powder of 4~10 μ m behind the ultra micro breaking cellular wall, manufactured goods keep moisture 4~9%;
C, two steps of a, b are made thing mix and add 0.4~1.5 times of pharmaceutic adjuvant, evenly stir and make granule dosage form or capsule after vacuum spray drying is handled.
2, complex prescription SANHUANGSAN according to claim 1, it is characterized in that adopting supersonic speed four-way molecule head-on collision technology to carry out production and processing, concrete manufacture technology link is: coarse pulverization, the sieve that shakes, selecting crude drugs with winnower, ultra-fine, breaking cellular wall, ultra micro, handle through this kind ultramicrotechnique, drug cell molecule breaking cellular wall, diameter of aspirin particle is 5 μ m~10 μ m, and manufactured goods keep moisture 4~9%.
3, complex prescription SANHUANGSAN according to claim 1 is characterized in that best proportioning is: Cortex Phellodendri 20.9g, Radix Astragali 33g, Radix Scutellariae 31.9g, Semen Cuscutae 33g, Rhizoma Atractylodis Macrocephalae 24.2g, Herba Hedyotidis Diffusae 39.6g, Radix Pulsatillae 28.6g, Radix Bupleuri 17.6g, Herba Taraxaci 19.8g, Radix Saposhnikoviae 28.6g, Radix Glycyrrhizae 17.6g, Radix Angelicae Sinensis 33g, Cordyceps 44g, Rhizoma Curcumae 22g, Cortex Moutan 19.8g, Herba Violae 30.8g.
4, complex prescription SANHUANGSAN according to claim 1 is characterized in that: above-mentioned peroral dosage form can be granule, capsule, tablet or syrup, oral liquid.
5, according to claim 1 and 3 described complex prescription SANHUANGSANs, it is characterized in that: above-mentioned 16 flavor Chinese crude drugs, net weight 444.4 grams, every flavor is prepared with 6~18 times of dose-effect relationships, adds medical accessory and makes 1000 bags of granule dosage forms or 1000 seed lac wafers.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 200410021975 CN1234408C (en) | 2004-03-05 | 2004-03-05 | Compound Sanhuang powder |
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CN 200410021975 CN1234408C (en) | 2004-03-05 | 2004-03-05 | Compound Sanhuang powder |
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CN1559572A true CN1559572A (en) | 2005-01-05 |
CN1234408C CN1234408C (en) | 2006-01-04 |
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CN 200410021975 Expired - Fee Related CN1234408C (en) | 2004-03-05 | 2004-03-05 | Compound Sanhuang powder |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101129493B (en) * | 2007-08-17 | 2010-09-22 | 天津中天制药有限公司 | Antineoplastic anti-AIDS pharmaceutical composition and method of preparing the same |
CN102614467A (en) * | 2012-04-19 | 2012-08-01 | 钟波 | Traditional Chinese medical composition for treatment of acquired immunodeficiency syndrome and preparation method and application thereof |
CN104721702A (en) * | 2015-04-09 | 2015-06-24 | 山东省立医院 | Traditional Chinese medicine for treating colorectal cancer |
CN107259627A (en) * | 2017-06-22 | 2017-10-20 | 黄斌华 | Integration of drinking and medicinal herbs nano micromolecule and its preparation technology and integration of drinking and medicinal herbs food |
-
2004
- 2004-03-05 CN CN 200410021975 patent/CN1234408C/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101129493B (en) * | 2007-08-17 | 2010-09-22 | 天津中天制药有限公司 | Antineoplastic anti-AIDS pharmaceutical composition and method of preparing the same |
CN102614467A (en) * | 2012-04-19 | 2012-08-01 | 钟波 | Traditional Chinese medical composition for treatment of acquired immunodeficiency syndrome and preparation method and application thereof |
CN104721702A (en) * | 2015-04-09 | 2015-06-24 | 山东省立医院 | Traditional Chinese medicine for treating colorectal cancer |
CN107259627A (en) * | 2017-06-22 | 2017-10-20 | 黄斌华 | Integration of drinking and medicinal herbs nano micromolecule and its preparation technology and integration of drinking and medicinal herbs food |
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Publication number | Publication date |
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CN1234408C (en) | 2006-01-04 |
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Granted publication date: 20060104 |