CN1557379A - Anticanser medicine - Google Patents

Abstract

The anticancer medicine is ground gynostemma pentaphylla powder or gynostemma pentaphylla capsule. The medicine has no toxic side effect, less taken amount, low cost, and obvious cancer treating effect.

Description

A kind of cancer therapy drug

Technical field

The invention belongs to anticancer drug world.

Background technology

The Gynostemma cucurbitaceous plant has a lot of Herb Gynostemmae Pentaphylli not of the same race the Herb Gynostemmae Pentaphylli subordinate.In " Chinese Plants will " the 73rd volume first fascicle (publishing in 1986), having put down in writing the branch kind under the Gynostemma just has 11 kinds; But wherein putting down in writing can be used as medicine have only Herb Gynostemmae Pentaphylli (former mutation) [Gynostemma Pentaphyllum (Thunb) Makino] a kind of, and explanation has eliminating inflammation and expelling toxin, an eliminating phlegm and stopping cough function.In " Guangxi medicinal plants register " (Research Inst. of Chinese Traditional Medicine and Drugs, Guangxi Autonomous Reg compiles, the Guangxi People's Press publishes, 1986) book, put down in writing: Herb Gynostemmae Pentaphylli heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, be used for chronic tracheitis, have loose bowels, venom is controlled in external.

Prove through hundreds of years medicine practices, the above-mentioned Herb Gynostemmae Pentaphylli bitter in the mouth that is used as medicine, little sweet, cold in nature, the main spleen lung meridian of returning, function with invigorating the spleen and benefiting QI, promoting the production of body fluid to quench thirst, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, supplementing QI and nourishing YIN, tangible immunoregulation effect is arranged, the propagation that can effectively suppress multiple cancerous cell, being used in has obvious therapeutic effect in the multiple cancer.

Herb Gynostemmae Pentaphylli being used for the treatment of in the prior art of cancer, all adopted the prescription that the multi-flavor medicine is carried out compatibility, do not see and use single medicinal material treatment cancer and medicable report.And with in the medicine of Herb Gynostemmae Pentaphylli as Herba indigoferae Pseudotinctoriae in the prescription, curative effect differs greatly, and one of its reason is likely that compatibility is improper, and its property of medicine performance has influenced each other.

Summary of the invention

The technical problem to be solved in the present invention is the cancellation compatibe drug, with the unique ingredient of single medicinal material as the treatment cancer.

The present invention solves the problems of the technologies described above with following technical scheme: with the medicine that gets product behind the gynostemma pentaphyllum herb levigation.

The Herb Gynostemmae Pentaphylli powder can incapsulate stand-by.

The 7-9 month in 2003 was used for animal experiment by Guangxi Chinese medicine institute with the Herb Gynostemmae Pentaphylli powder that the applicant provides.Through mice is made drug test, rat liver cancer H22 solid tumor and murine sarcoma S180 solid tumor and ascites tumor all there are obvious antitumor action and can prolong the life span of mice, and can resist the mouse immune inhibitory action that dexamethasone causes, strengthen the mice delayed hypersensitive reaction, increase the mice half hemolysis value, strengthen mouse humoral immune and cellular immune function.In the animal experiment of acute toxicity, raise Mus with 19.2g/Kg day dose, each Mus outward appearance, behavior, extremity activity, fur, feed, drainage there is no unusually, and animal does not have death, does not have obvious toxic reaction, and body weight gain is normal, average weightening finish 21% in 7 days.

The applicant year has done the part clinical trial in nineteen eighty-two-2003.Drug effect to this medicine is verified.The clinical effectiveness grade scale that is adopted is:

1 effectively after treating symptom and body constitution took a favorable turn than originally, complexion is good, immunity increases.Check discovery cancerous protuberance piece can have been controlled to such an extent that live, no longer grows up, and all other check basic with equally constant originally.

2 produce effects transference cure after treating, immunity is much improved, and is healthy, and complexion is good.Check finds that the cancerous protuberance piece dwindles, and all other check results take a turn for the better to some extent.

3 recoveries from illness: transference cure after treating, immunity and body constitution are recovered fully, and is healthy, and complexion is good, and the life work is as ordinary person.Cancerous protuberance piece and cancerous cell are not seen in check, check that comprehensively every result shows normally.

306 routine cancer patients have used medicine of the present invention to treat, and the effective percentage of statistics is 98%, and obvious effective rate is 87%, and cure rate is 36%.

Below provide numerical example that the model case of recovery from illness effect is arranged:

1, permitted * *, woman, 48 years old now, Lian Long village, Longan County, Guangxi Yan Jiang people from town.Find that there is a lump the outer top of right breast such as egg is big, quality is harder, superficial, the surface is rough and uneven in surface in March, 1998, with the unclear lump of surrounding tissue boundary, lump and the adhesion of breast epidermis, nipple obviously bounces back, and finds cervical region and the lymphadenectasis of axillary fossa place.X ray and cytohistology inspection are done to No.1 Hospital Attached to Guangxi Medical Univ. in the back, and biological tissue is cut into slices and to be done pathologic finding, are diagnosed as breast carcinoma late period at last.Cyclomastopathy, mammary gland fibroma have been got rid of.Through taking anticancer drug therapy of the present invention, the 3.6 gram treatments of day this medicine of clothes are after five months, and healthy, complexion is good, and immunity is recovered fully.Do the X ray check to this hospital again August in the same year and do not see the cancerous protuberance piece, cancerous cell is not found in the cytohistology inspection.Recovery from illness 5 years so far, the life work is normal.

2, yellow * *, the man, 57 years old now, Wuming County Luo Xu town, Guangxi Lin Yang people from village, the sense discomfort had the sensation of retention of food dysphagia in esophagus when swallowed food in March, 1988.The cystose mucus that often spues to June, sense of obstruction increases the weight of, and with shirtfront and back persistence dull pain.The people becomes thin, body constitution worse and worse, and clavicle lymphadenectasis.X ray esophagus barium manufacturing shadow is made to Affiliated Hospital of Guangxi Medical University in the back, and getting pathological tissues, to do the pathology inspection be 1/3 section scale cancer in the esophagus, got rid of esophagus chronic inflammatory disease etc., is diagnosed as advanced esophageal cancer.Through taking the 3.6 gram treatments of this medicine day after five months, there has not been other symptom, weight increase, healthy, complexion is good, and immunity is recovered fully.Advance barium meal again to this hospital again November in the same year and take the photograph sheet confirmation foci disappearance.Pathologic finding does not find cancerous cell.So far 15 years, the life work was normal.

3, the week *, man, 54 years old now, Guiping County, Guangxi fiber crops Dong Xiang people from Zhou village.In May, 1987 proctalgia, stool shape is thin, is with blood sometimes, few abdomen expands, and becomes thin, weak and anemia enclosed mass in the abdomen.Enteroscopy is done to Affiliated Hospital of Guangxi Medical University in the back, finds that internal rectum has cauliflower like mass.Getting the pathological tissues biopsy is rectal adenocarcinoma.Got rid of chronic enteritis etc.Be diagnosed as intestinal cancer late period.Through take day the treatment of this medicine 3.6 gram after five months all symptoms disappear entirely, weight increase, healthy, complexion is good, immunity is recovered fully.Do the check of intestinal mirror to this hospital October in the same year again, and microscopy recovers normal as a result, does not find lump, and cancerous cell is not found in biopsy, proves recovery from illness.So far 16 years, the life work was normal.

4, old * *, man, 56 years old now, new wonderful people from village in big temple town, Qinzhou City, Guangxi.In February, 1993, carrying out property of chest pain three months was a little less than people's body slimming because of cough, sputum mixed with blood.The X ray chest film inspection is made to Affiliated Hospital of Guangxi Medical University in the back, is reported as the left side central type carcinoma of lung, and lump in the right hypochondrium liquid under in the left side.Cough the anabole inspection, pathological replacement is a squamous cell carcinoma.Get rid of pulmonary tuberculosis etc., be diagnosed as pulmonary carcinoma late period and hydrothorax.Asymptomatic, healthy after six months through taking the 1.2 gram treatments of this medicine day, complexion is good, and immunity is recovered fully.Do the X ray check to this hospital November in the same year again, and the result does not find cancerous protuberance piece and hydrothorax, sees that two lung fields are clear, and pathologic finding does not find cancerous cell.The proof recovery from illness.So far 10 years, the life work was normal.

5, Wu * *, the woman, 56 years old now, the retirement, the worker of Yulin Prefecture, Guangxi machinery plant.Chronic hepatitis 5 years, nearly January, distention and fullness in the abdomen was indigestion and loss of appetite, becomes thin, carrying out property hepatomegaly, hepatic region severe pain also reflexes to waist.Show do ultrasound investigation to Affiliated Hospital of Guangxi Medical University in May, 1988: liver increases, and it is smooth that owe on the surface, visits and one 8.7 * 7.6cm essence agglomerate in the right back leaf of liver, and owe clearly on the limit, irregular, and echo strengthens uneven.Visit and the low echo group of one 1.6 * 1.5cm in right front leaf in addition, the limit is clear, echo is owed all, and quiet right skill of door and left skill shape portion are by substantive agglomerate filling, and the interior blood vessel of liver is owed clearly, and gallbladder is thick slightly crude.Prompting: (1). the liver parenchyma occupying lesion and the portal vein right side, left skill tumor bolt.(2). cholecystitis.Liver function test is undesired.HBSAG checks positive, and alpha-fetoprotein is checked positive by ATP.Got rid of simple cholecystitis etc.Being diagnosed as (1). the left and right skill of primary hepatocarcinoma late period and portal vein is fastened plug bitterly.(2) cholecystitis.Symptom disappears entirely after day, clothes 3.6 these medicines of gram were treated five months, weight increase, and healthy, complexion is good, and immunity is recovered fully.Doing the ultrasound wave check to this hospital again October in the same year shows: 1 liver is little, and luminous point is good, does not see occupy-place.2 gallbladder no abnormality seens.The liver function check is normal, HBSAG feminine gender, alpha-fetoprotein ATP feminine gender.The proof recovery from illness.So far 15 years, the life work was normal.

6, Wei * *, man, 62 years old, town veterinary station worker in the county town, Ningming, Guangxi.In April, 1988, the food of receiving was die-offed because of Upper abdominal pain and abdominal distention aggravation, with nauseating, vomiting, loss of appetite, scorching hot, the shallow complexion of stomach, and emaciated physique, and find the left clavicle lymphadenectasis, epigastrium is laid one's hand on lump.The X ray barium meal examination is done to Affiliated Hospital of Guangxi Medical University in the back, sees that the curved greatly side of body of stomach has a lump such as egg big, and periphery rots as being stung by mouse.Getting pathological tissues, to make the pathology cytoscopy be adenocarcinoma anaplastic.Get rid of gastric ulcer etc., be diagnosed as gastric cancer late period.Through taking the 3.6 gram treatments of this medicine day after five months, all symptoms disappear entirely, and weight increase is healthy, and complexion is good, and immunity is recovered fully.JIUYUE was made the X ray barium meal to this hospital again and was rechecked and to look into the same year, the lump complete obiteration, and pathologic finding does not find cancerous cell.The proof recovery from illness.So far 15 years, the life work was normal.

7, yellow * *, man, 52 years old now, auspicious all townshiies Lian Fu people from village in Tiandong County, Guangxi.Suffered from chronic hepatitis B 4 years.Thin, the abdominal distention of body in nearly one month, thoracoepigastric veins is angry to be opened, carrying out property hepatosplenomegaly, pain in the hepatic region, the obvious edema of two lower limb, diet is gradually few.Show do ultrasound investigation to Affiliated Hospital of Guangxi Medical University in June, 1985: liver is splenauxe, visits and a plurality of essence agglomerate that differs in size in right lobe of liver, and the maximum is 6.2 * 5.8cm, and owe clearly on the limit, irregular, and echo strengthens uneven.The liver periphery has the opaque dark area of fluid.Prompting: (1) liver parenchyma occupying lesion.(2) hepatic ascites.Liver function test is undesired, the HBSAG positive, and alpha-fetoprotein ATP checks positive.Got rid of simple cirrhotic ascites etc.Be diagnosed as primary hepatocarcinoma late period and ascites.Through take day the treatment of this medicine 1.2 gram after six months ascites and other symptom disappear entirely, weight increase, healthy, complexion is good, immunity is recovered fully.December was done ultrasound wave check to this hospital again and shown the same year: 1 hepatomegaly is little normal, and blood vessel moves towards clear in the liver, and echo is evenly distributed in the liver, does not see occupy-place.2 spleens are little.The liver function check is normal, the HBSAG feminine gender, and alpha-fetoprotein is checked negative by ATP, prove recovery from illness.So far 18 years, the life work was normal.

8, Lee * *, woman, 36 years old now, Lian Xing people from village, town, the Wuming County city proper and areas just outside its gates, Guangxi.The excuse tears blood of having a stuffy nose bitterly is surplus March.Look into upper left neck region lump 3 * 3cm, matter is hard, and is movable poor, and arrive Guangxi Medical University Affiliated Hospital row nasopharynx part radiography behind the sx in May, 1987, sees that left side wall is full not good enough, and the pathology biopsy is seen cancerous cell for low differentiated squamous-cell carcinomas, cervical region enclosed mass puncture.Get rid of chronic nasopharyngitis etc., be diagnosed as nasopharyngeal carcinoma late period.Through taking the 3.6 gram treatments of this medicine day after five months, all symptoms disappear entirely, and the cervical region enclosed mass disappears, weight increase, and healthy, complexion is good, and immunity is recovered fully.Do the nasopharyngeal endoscope check to this hospital October in the same year again, sees that nasopharynx part is smooth, no neoplasm, and pathological changes portion biopsy does not find cancerous cell.The proof recovery from illness.So far 16 years, the life work was normal.

Because Herb Gynostemmae Pentaphylli has no side effect, dosage is few, and cost is low, and the problem that does not interact drug effect even have side effects in the medicine, and it is evident in efficacy to control cancer.

The specific embodiment

Used Herb Gynostemmae Pentaphylli is a herb, gathers autumn to clean and dries.To clean drying in the sun gynostemma pentaphyllum herb levigation, can directly take after crossing 100 mesh sieves, or incapsulate and facilitate patients.

Embodiment 1:

To clean drying in the sun Herb Gynostemmae Pentaphylli herb and be ground into powdery, and cross 80 mesh sieves, medicated powder gets product.

Embodiment 2:

To clean drying in the sun Herb Gynostemmae Pentaphylli herb and be ground into powdery, behind 80 mesh sieves medicated powder be incapsulated excessively, every capsules powder charge 0.2 gram.

Embodiment 3;

To clean the drying in the sun gynostemma pentaphyllum herb and be ground into powdery, behind 80 mesh sieves medicated powder be incapsulated excessively, every capsules powder charge 0.3 gram.

Claims (2)

1, a kind of cancer therapy drug, pastille grass Herb Gynostemmae Pentaphylli is characterized in that the medicine that gets product behind the gynostemma pentaphyllum herb levigation.

2, cancer therapy drug as claimed in claim 1, it is stand-by to it is characterized in that Herb Gynostemmae Pentaphylli powder can incapsulate.