CN102283988A - Preparation method for traditional Chinese medicine capable of enhancing antineoplastic activity of patient and leaching liquor thereof - Google Patents
Preparation method for traditional Chinese medicine capable of enhancing antineoplastic activity of patient and leaching liquor thereof Download PDFInfo
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- CN102283988A CN102283988A CN201010253779XA CN201010253779A CN102283988A CN 102283988 A CN102283988 A CN 102283988A CN 201010253779X A CN201010253779X A CN 201010253779XA CN 201010253779 A CN201010253779 A CN 201010253779A CN 102283988 A CN102283988 A CN 102283988A
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Abstract
The function of traditional garlic on prevention and treatment of tumors is definite. However, the traditional garlic has strong flavor and does not accord with dietary habits; in addition, garlicin in the garlic is easy to decompose after being heated, thus the garlic is difficult to control and is not suitable for popularization. The invention provides a preparation method of an effective traditional Chinese medicine for treating the tumors and leaching liquor thereof. By digging the traditional Chinese medicine of black garlic for effectively inhibiting the tumors, the advantages of the traditional Chinese medicine of the state for treating the tumors are fully exerted to benefit tumor patients. Therefore, the research on a molecular mechanism of the black garlic is deepened; and by applying various technical means, a clinical action mechanism of the black garlic is learned from the view of cells and gene protein. For conducting and serving the clinical application, main technical strategies contained in the invention comprise black garlic leaching liquor cytotoxicity, the change of the cellular morphology caused by the treatment of the black garlic leaching liquor, the growth relation of the black garlic leaching liquor on tumor tissues in a tumor-bearing mice body, inhibiting ability of the black garlic leaching liquor on various tumor cells in the mice body, the reduction of imunodefficiency caused by cyclophosphamide through the black garlic leaching liquor and the like.
Description
Technical field
The present invention relates to association areas such as Chinese medicine, Chinese materia medica, oncology, pharmacology.Show that according to the Ministry of Public Health data malignant tumor has become one of major causes of death of China resident, whole world kainogenesis last year tumor patient has more than 1,100 ten thousand examples, and wherein 1,800,000 examples occur in China.In the face of soaring year by year tumor incidence, though the tumor Medical Technology that human wisdom is brought in constant renewal in has been gathered various means such as operation, radiotherapy, chemotherapy, Biotherapeutics, but still can not eliminate malignant tumor, the recurrence of tumor and transfer are also being perplexed medical circle.The pathogenic factor of tumor is common three: hypoimmunity, vivotoxin gather, nutrient imbalance.How to launch treatment around these three aspects, should be effective to tumor, safety reduces toxic and side effects again, also will consider that this is the basic point and the starting point of oncotherapy for patient's ability to shoulder economically.
Background technology
Tumor science treatment New Policy, breakthrough with operation, radiation and chemotherapy as the limitation of the treatment malignant tumor of first-selection, advocate the body and mind integral rehabilitation of oncotherapy, the modern thermotherapy technology of doctor trained in Western medicine, chelating toxin expelling technology and traditional Chinese medicine, acupuncture, trophotherapy, three oxygen therapys, medical qigong and psychological consultation are melted into a whole.The control that the black Bulbus Allii preparation is used for tumor just is being based on this theory and is producing.
Bulbus Allii mainly contains 18 kinds of amino acids, vitamin (C, B, A), trace element (phosphorus, potassium, magnesium, sodium, calcium, calcium, silicon, aluminum, zinc, selenium, germanium), sulfur-containing compound, carbohydrate.The comprehensive active power of black Bulbus Allii is more than 10 times of common Bulbus Allii, and resistance to oxidation is more than 15 times of common Bulbus Allii.The main effect of black Bulbus Allii derives from three kinds of composition-Ai Qiaoen, polyphenols and free amino acids that are rich in the black Bulbus Allii, and the polyphenols content of black Bulbus Allii is Duoed more than 10 times than living Bulbus Allii, and the free aminoacid content of black Bulbus Allii is 1.5 times of living Bulbus Allii.The black Bulbus Allii preparation is a kind of up-to-date in the world Bulbus Allii converted products, discovers, Bulbus Allii is after the processed through time of certain temperature, humidity and one, enzyme generation enzymatic reaction in the Bulbus Allii, with big allinase ferment, can remove the acid of Bulbus Allii, mouthfeel is also good.Comprehensive various data, the Bulbus Allii after (being black Bulbus Allii) has the trend that replaces garlic products by fermentation.
The chemical compound of black Bulbus Allii is kind more than 30 nearly, mainly contain 11 kinds: 3,3-dithio-1-propylene, diallyl disulfide list oxide (allicin, CH2=CH-CH2-SOSCH2-CH=CH2, character is extremely unstable, very easily self be condensed into Ah's hopene, be Bulbus Allii alkene again, Allifridin), methacrylic sulfur (CH3-S-CH2-CH=CH2), 1-methyl-2-propyl disulfide thing-3-methoxyhexane, ethylidene [1,3] dithiane, S, S-dipropyl methyl-carbithionic acid ester, diallyl disulfide (garlicin Diallyldisulfide, CH2=CH-CH2-S-S-CH2-CH=CH2), the diallyl trisulfide (allicin, CH2=CH-CH2-S-S-S-CH2-CH=CH2), diallyl tetrasulfide (CH2=CH-CH2-S-S-S-S-CH2-CH=CH2), diallyl thiosulfates (CH2=CH-CH2-SO2-S-CH2-CH=CH2).
The medical board professor Zuo Zuo of Japan famous physician, hirosaki university wood very one proves that by animal experiment the effective ingredient of black Bulbus Allii has had strong inhibitory effects to malignant cell.Studies show that, ethane thiosulfonic acid ethyl ester in the black Bulbus Allii and diallyl trithio from many aspects blocking nitrosamine formation in the formation and the accumulation of stomach; Ge element in the black Bulbus Allii is strong anticancer trace element, can suppress the carcinogen nitrosamine, plays anti-cancer, anticancer effect.One of black Bulbus Allii main component is a garlicin, can increase the permeability of tumor cell about the garlicin that studies show that of black Bulbus Allii Chinese medicine lixiviating solution, causes the destruction of cell membrane.Act on nucleus after black Bulbus Allii Chinese medicine lixiviating solution effective ingredient enters tumor cell, destroy the nucleus of division stage, make the chromosome disintegrate, caryoplasm overflows, thereby causes the death of tumor cell.In one word, this flavor Chinese medicine antitumor action can be summarized as: black Bulbus Allii can be blocked the synthetic of carcinogen nitrosamine, and the anticancer growth has lethal effect to cancerous cell.Ah's hopene (Allifridin) and tool chemical stability are especially remarkable to leukaemia's growth inhibited effect to kinds of tumor cells.
Summary of the invention
A kind of Chinese medicine and lixiviating solution preparation method thereof that strengthens patient's anti-tumor activity.The Chinese medicine black Bulbus Allii is provided by Dalian Huagu Garlic Co., Ltd., and whole Bulbus Allii crust drying easily peeled off, and garlic clove is the preserved fruit paste, does not have any pungent taste, the fruit jelly taste, and mouthfeel is good.Claim black Bulbus Allii beans 100g, adding distil water to 1000ml in 80 ℃ of water-baths after 2 hours, stir frequently, filtered through gauze is removed filtering residue and is got filtrate, Rotary Evaporators is condensed into 50ml (being equivalent to the 2g/ml crude drug), after the degerming of 0.22um membrane filtration, store for future use in 4 ℃, so far black Bulbus Allii presses down tumor effective ingredient lixiviating solution and makes.Get in a little LB antibacterial culturing agar plate, antibacterial culturing is negative and is as the criterion.
Find by clinical observation and evaluation back 105 routine tumour patients, this Chinese medicine lixiviating solution is with its significant advantage on aspect the therapy of combining Chinese and Western medicine tumor, when having the characteristic of no side effects, aspect improving infantile tumour patient cure rate, control tumour patient relapse rate in mid-term, prolonging the patients with advanced cancer life span, all obtained good clinical therapeutic efficacy.
The specific embodiment
Comprise (one). the preparation of black Bulbus Allii lixiviating solution; (2). zoopery is estimated the black Bulbus Allii lixiviating solution and is pressed down the tumor effective percentage; (3) clinical practice efficiency evaluation-various indexs behind tumor patient detect contrast; (4). statistics and tracking are followed up a case by regular visits to.
(1). the preparation of black Bulbus Allii lixiviating solution claims black Bulbus Allii beans 100g, adding distil water to 1000ml in 80 ℃ of water-baths after 2 hours, stir frequently, filtered through gauze is removed filtering residue and is got filtrate, Rotary Evaporators is condensed into 50ml (being equivalent to the 2g/ml crude drug), after the degerming of 0.22um membrane filtration, store for future use in 4 ℃, so far black Bulbus Allii presses down tumor effective ingredient lixiviating solution and makes.Get in a little LB antibacterial culturing agar plate, antibacterial culturing is negative and is as the criterion.
(2). the black Bulbus Allii lixiviating solution is estimated in zoopery but tumor effective percentage 1. will be inoculated 8 days ascites tumor mice of H22 tumor kind to take off the execution of neck method, aseptic condition extracts ascites tumor cell suspension 5ml down, through centrifugal dilution, with normal saline suspension cell again, concentration of cell suspension is 1 * 10
10/ L; Only be inoculated in the right oxter of mice with 0.2mL/, make the solid tumor animal model.Be divided into five groups at random behind the inoculation 24h: dosage group (400mg/kg. time), black Bulbus Allii water extract high dose group (800mg/kg. time) in negative control group (0.9%Nacl. time), positive controls (cyclophosphamide, 60mg/kg. time) black Bulbus Allii water extract low dose group (200mg/kg. time), the black Bulbus Allii water extract.2. inoculate beginning splanchnocoel perfusion administration on the 3rd.The heating group needs after the administration mice placed 42 ℃ of waters bath with thermostatic control 30min that heats.Perfusion in per 2 days 1 time is treated 7 times.Treatment was observed the 14th day, claimed the mice body weight, and mice is put to death in the cervical vertebra dislocation, strips tumor piece, spleen and thymus, weighs, and calculates tumor control rate, thymus index and spleen index.Tumor control rate=(negative control group tumor weight-test group tumor is heavy)/negative control group tumor heavy * 100%; Spleen index=spleen weight in wet base (mg)/body weight (g); Thymus index=thymus weight in wet base (mg)/body weight (g).3.MTT method detects (tumor cell counting method) and surveys the growth and proliferation of cell curve and ask cell doubling time: (1) take the logarithm cell trypsinization of trophophase, make cell suspension with culture fluid.It is 5 * 104/ml that cell density is adjusted in the counting back, and cell is inoculated in six orifice plates respectively, every hole inoculation 5 * 104 cells, and the amount of every hole culture fluid is 3ml.(2) getting the cell tryptase enzymic digestion counting cells sum in 3 holes every 24 hours, observe 6 days (changing liquid for the cell of no count every 2 days) continuously, is transverse axis with the incubation time, and cell number is the longitudinal axis, utilizes Excel software to depict the growing multiplication curve of each cell.(3) utilize the growth and proliferation of cell curvilinear equation, calculate cell doubling time.
In the antitumous effect and experimental Study on Mechanism of above black Bulbus Allii Chinese medicine lixiviating solution to rat liver cancer, by the MTT Experimental Evaluation the direct cytotoxic activity of black Bulbus Allii Chinese medicine lixiviating solution, zoopery shows that black Bulbus Allii Chinese medicine lixiviating solution has tangible antitumous effect in vivo, and the tumour inhibiting rate statistics sees Table 1.And surveying cytotoxic activity with the LDH method for releasing, the result shows that black Bulbus Allii Chinese medicine lixiviating solution has direct cytotoxicity to tumor, and has produced the lymphocyte at tumor cell after the treatment of black Bulbus Allii Chinese medicine lixiviating solution.
Table 1. black Bulbus Allii lixiviating solution to the influence of Hep.A22 tumor-bearing mice tumor bulk-growth (X ± S, n=20)
Note：Compared?with?negative?control?group，**：P＜0.05，*P＜0.01.
(3). clinical practice is efficiency evaluation (various indexs detect contrast) behind tumor patient; (4). statistics and tracking are followed up a case by regular visits to
1. clinical example explanation
The using method of this medicine: the patient after making a definite diagnosis tumor, every day three times, each oral 37g black Bulbus Allii, warm water takes, during prohibit fish raw meat, pungent group food.Enumerate the clinical pharmacodynamic analysis report of the 105 routine tumor patients that the applicant treated in 1 year half: a. physical data: in 105 examples, male's 76 examples, women's 29 examples, age 40-78 year, III phases 65 example wherein, IV phases 40 example.B. medical diagnosis on disease standard: diagnose according to the international staging diagnosis standard of clinical general TNM.C. administrated method: use this Chinese medicine every day 3 times, each 37g.Be a course of treatment January.D. curative effect judging standard:, and keep at least more than 4 weeks according to all visible focus complete obiterations of WHO curative effect measurement standard 1.CR.2.PR the tumor total amount is estimated to reduce more than 50%, and keeps at least more than 4 weeks.3.NC after the treatment of 2 weeks, focus does not have significant change at least, comprises that focus is stable, estimates that tumor reduces＜50%, estimates that tumor increases＜25%.4.PD new focus occurs, perhaps original focus is estimated to increase＞25%.5. result statistics: CR 2 examples, it is several 1% to account for total example, PR 36 examples, it is several 34% to account for total example, NC 45 examples, it is several 42% to account for total example, and PD 22 examples account for total example several 23%.
The present invention effectively suppress malignant tumor case for example:
Leading case 1, king X, man, 45 years old, in in July, 2009 because of zest dry cough occurring, with being admitted to hospital in uncomfortable in chest, the January of feeling suffocated, find the lump of an about 2*2cm size on the left clavicle, show in my institute's row breast CT: left hilus pulumonis occupy-place, the about 4*5cm of size, the multiple enlarged lymph node of mediastinum and left clavicle.Fiberoptic bronchoscopy is shown scale cancer.Have a medical check-up: blood pressure: 120/70mmHg, left pulmonary respiration sound is thick, audible and a small amount of moist rale, the about 2*2cm of lump size on the clavicle, matter is hard, and mobility is poor, no tenderness.Laboratory is looked into: CEA:259.746ng/ml.AD: left lung central type carcinoma of lung T3N3M0 III phase.The patient is because of economic cause refusal row chemicotherapy.Therapeutic scheme: give this Chinese medicine every day 3 times, each 37g cooperates symptomatic treatments such as oxygen uptake, antibiotic, and be 1 course of treatment January, and check CT shows after February: left pneumonopathy kitchen range is more preceding obviously to be dwindled, the about 1*1.5cm of size.Two lungs are not heard and dried moist rale.Laboratory is looked into: CEA:176.389ng/ml.
2. XX of leading case, the man, 54 years old, surplus because of hepatocarcinoma postoperative 3 years in JIUYUE, 2009, be admitted to hospital weak uncomfortable January.In showing in Dongfang Liver and Gall Surgery Hospital's row abdominal part enhanced CT: multiple occupy-place in the liver, the most about 2*4cm, row hepatocarcinoma is partly excised, and postoperative pathology shows hepatocarcinoma.Capable subsequently liver interventional therapy 10 times, the patient shows multiple transfer the in the liver because of weak check CT before January, and portal vein tumor thrombus forms, and operation and interventional therapy are refused to go by east, Shanghai Genneral Surgery.Have a medical check-up: abdomen is soft, does not have obvious tenderness and rebound tenderness, checks: AFP:420ng/ml.AD: primary hepatocarcinoma IV phase.Therapeutic scheme: give this Chinese medicine every day 3 times, each 35g cooperates hepatic, and be 1 course of treatment January, and check CT shows after February: hepatic neoplasms does not have significant change, AFP:160ng/ml.
Leading case 3. Liu XX, the woman, 59 years old, surplus in February, 2009 because of abdominal distention 1 year, increase the weight of February and be admitted to hospital.The patient is diagnosed as ovarian cancer in 301 Hospital of PLA before 1 year, row ovarian cancer radical correction, and postoperative pathology is adenocarcinoma III level.The capable 8 cycle chemotherapy of postoperative.The abdomen pelvic cavity CT that moves ahead February shows: multiple lymph node behind liver and the peritoneum, row pelvic field 1 cycle of radiotherapy.Have a medical check-up: abdominal tympanites, hypogastric region tenderness, no rebound tenderness, the shifting dullness positive.Check: CA125:350.784U/ml.AD: ovarian cancer IV phase.The patient refuses the row chemicotherapy.Therapeutic scheme: give this Chinese medicine every day 3 times, each 37g cooperates antibiotic therapy, and be 1 course of treatment January, and ascites disappears after February.Look into CA125:98.635U/ml.
Conclusion: this Chinese medicine has and has no side effect, and gastrointestinal reaction is light, and antitumor, sterilization are easy to use, and tumor is had the obvious suppression effect.
Claims (2)
1. technical characterictic:
The present invention relates to the middle pharmaceutically active ingredient lixiviating solution compatibility of treatment and prevention of tumour: under the prerequisite that guarantees material quality, claim black Bulbus Allii 100g, adding distil water to 1000ml in 80 ℃ of water-baths after 2 hours, stir frequently, filtered through gauze is removed filtering residue and is got filtrate, Rotary Evaporators is condensed into 50ml (being equivalent to the 2g/ml crude drug), after the degerming of 0.22um membrane filtration stores for future use in 4 ℃.Get in a little LB antibacterial culturing agar plate, antibacterial culturing is negative and is as the criterion; The present invention adds does not have boiling water bath and boiling process man-hour, guarantees that to greatest extent black Bulbus Allii presses down the stability and the effectiveness of tumor composition, and effectively reduces the probability of pollution and recontaminate; Continued operation, layoutprocedure is easier; Product has kept original effective components to greatest extent; Gained Chinese medicine of the present invention has and has no side effect, and gastrointestinal reaction is light, antitumor, sterilization, easy to use, tumor is had the obvious suppression effect, and average tumour inhibiting rate can reach more than 35%, and SOD superoxide dismutase, Polyphenols content are higher than common white garlic goods.
2. principal claim:
Black Bulbus Allii lixiviating solution collocation method: provide genuine medicinal materials with market-oriented black Bulbus Allii product, whole Bulbus Allii crust drying easily peeled off, and garlic clove is the preserved fruit paste, does not have any pungent taste, the fruit jelly taste, and mouthfeel is good; Claim black Bulbus Allii 100g, adding distil water after 2 hours, stirs in 80 ℃ of water-baths frequently to 1000ml, and filtered through gauze is removed filtering residue and got filtrate, and Rotary Evaporators is condensed into 50ml (being equivalent to the 2g/ml crude drug), after the degerming of 0.22um membrane filtration stores for future use in 4 ℃; Get in a little LB antibacterial culturing agar plate, antibacterial culturing is negative and is as the criterion, and so far, black Bulbus Allii presses down tumor effective ingredient lixiviating solution to be made successfully; By being used to observe, routine tumor patient surplus nearly 100 clinical estimate, the black Bulbus Allii lixiviating solution is with its significant advantage on aspect the therapy of combining Chinese and Western medicine tumor, aspect improving infantile tumour patient cure rate, control tumour patient relapse rate in mid-term, prolonging the patients with advanced cancer life span, all obtained good clinical therapeutic efficacy; And maximum advantage is this Chinese medicine no side effects.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596673A (en) * | 2016-01-28 | 2016-05-25 | 广东益生康生物科技有限公司 | Black garlic extract and application thereof in preventing and curing tongue cancer |
| CN105596674A (en) * | 2016-01-28 | 2016-05-25 | 广东益生康生物科技有限公司 | Black garlic extract and application thereof in preventing and curing breast cancer |
| CN106806885A (en) * | 2015-11-30 | 2017-06-09 | 孙勋 | A kind of medicine of integrative therapy lung cancer and preparation method thereof |
| CN108671202A (en) * | 2018-07-26 | 2018-10-19 | 广西中绿医药科技有限公司 | Prostate cancer healing liquid and preparation method thereof |
| CN110461160A (en) * | 2017-03-30 | 2019-11-15 | 莫特迩公司 | Antimicrobial garlic composition |
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| CN101731605A (en) * | 2008-11-18 | 2010-06-16 | 杨侠 | Method for producing and processing black garlic |
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| DONG YEOK SHIN ET AL: "Effects of Aged Black Garlic Extracts on the Tight Junction Permeability and Cell Invasion in Human Gastric Cancer Cells", 《JOURNAL OF LIFE SCIENCE》, vol. 20, no. 4, 30 April 2010 (2010-04-30), pages 528 - 534, XP053021962 * |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106806885A (en) * | 2015-11-30 | 2017-06-09 | 孙勋 | A kind of medicine of integrative therapy lung cancer and preparation method thereof |
| CN105596673A (en) * | 2016-01-28 | 2016-05-25 | 广东益生康生物科技有限公司 | Black garlic extract and application thereof in preventing and curing tongue cancer |
| CN105596674A (en) * | 2016-01-28 | 2016-05-25 | 广东益生康生物科技有限公司 | Black garlic extract and application thereof in preventing and curing breast cancer |
| CN110461160A (en) * | 2017-03-30 | 2019-11-15 | 莫特迩公司 | Antimicrobial garlic composition |
| CN110461160B (en) * | 2017-03-30 | 2022-06-17 | 莫特迩公司 | Antimicrobial garlic composition |
| CN108671202A (en) * | 2018-07-26 | 2018-10-19 | 广西中绿医药科技有限公司 | Prostate cancer healing liquid and preparation method thereof |
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Application publication date: 20111221 |