CN1557301A - Compositions for senile diabetes patient blood sugar and blood fat reduction - Google Patents
Compositions for senile diabetes patient blood sugar and blood fat reduction Download PDFInfo
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- CN1557301A CN1557301A CNA2004100158666A CN200410015866A CN1557301A CN 1557301 A CN1557301 A CN 1557301A CN A2004100158666 A CNA2004100158666 A CN A2004100158666A CN 200410015866 A CN200410015866 A CN 200410015866A CN 1557301 A CN1557301 A CN 1557301A
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Abstract
The present invention is method of replenishing essential nutritive components to lower body's blood fat and blood sugar. Free amino acids and chromium picolinate are provided to replenish amino acids and trivalent chromium, and this can irritate the release of body's growth hormone, strengthen muscle, reduce fat, improve blood fat metabolism, strengthen glucose tolerance factor effect, reduce insulin resistance, lower blood sugar and improve blood sugar metabolism. The said method is suitable for obese senile people to prevent and treat type-II diabetes and metabolism syndrome.
Description
Affiliated technical field:
The present invention relates to treat old obese type, non-insulin-dependent (II type) diabetes.More particularly, the present invention relates to by using aminoacids complex and three chromium picolinates are treated the type ii diabetes patient.
Background technology:
Diabetes are a kind of chronic metabolic disease, and the whole world has 100,013,000 patients approximately, and China has 50,000,000 patients approximately, also have a lot of people not obtain diagnosis as yet in addition.Noninsulindependent diabetes (or claiming type ii diabetes) much occurs in old age, obese type crowd.Principal character is to cause insulin resistant owing to fat with lacking exercise, blood glucose can not effectively be utilized and cause hyperglycemia, and then stimulate beta Cell of islet to discharge more insulin, remedy the deficiency of Board Lot insulin blood sugar lowering ability, finally cause the beta Cell of islet function impaired, the secretion of insulin compensatory capacity descends, and blood glucose continues to raise, and then destroys trunk and blood capillary and cause multiple internal organs And such as cardiovascular, cerebrovascular, eyes, kidney to send out disease.Type ii diabetes mostly occurred after 40 years old, and sickness rate was directly proportional with the age, and how with obesity, hypertension, hyperlipidemia etc.Multiple zoopery and clinical research prove, the pathogeny of diabetes and obesity have very big degree of association, usually the diabetes patient is after losing weight, blood glucose and blood fat can both be well controlled, and the generation of diabetes, development are relevant with some nutrients shortage, for example human body lacks chromium and can cause glucose, lipid and dawn white matter metabolism disorder, chromium is the important composition part of glucose tolerance factor, be that insulin active remains on the requisite bioactive substance of optimum state, chromium deficiency can cause forfeiture of insulin physiologic function and glucose metabolism disorder.
In addition, with age, human body inner growth hormone and other multiple hormone secretions reduce, the movable minimizing causes body fat to be piled up, triglyceride and cholesterol raise in the blood, all reduce insulin sensitivity, increase insulin resistant, the insulin bioavailability is obviously reduced, and because the internal metabolism disorder, digestive and absorptive functions reduces, and causes the shortage of essential amino acids, cause the dyssynthesis of various active peptide, hormone, enzyme and dawn white matter in the body, further aggravate disease.
The common drug that is used for the clinical treatment type ii diabetes at present mainly contains two classes, i.e. biguanides and sulfonylurea.Biguanides oral antidiabetic drug such as metformin, phenformin, main effect are to promote picked-up and the utilization of tissue to sugar, reduce the glycogen heteroplasia, thereby reduce glycogen output; Sulfonylurea such as tolbutamide and glibenclamide, main effect are to stimulate the beta Cell of islet excreting insulin, strengthen the effect of Insulin receptor INSR in the peripheral tissues, and glycogen decomposes in the minimizing liver.Biguanides has been proved and can have caused lactic acidosis, and especially for the diabetics of renal insufficiency, mortality rate can reach 50%, and sulfonylureas often causes patient that hypoglycemic reaction takes place.And above-mentioned two class medicines produce drug resistance and effective glucose level control after taking half a year～one year.Therefore, seek safe and reliable, effectively help the supplementary of diabetes patient's blood sugar lowering and blood fat, with blood glucose and the blood lipid metabolism of improving the diabetes patient, it is very urgent that controlling symptoms, prevention And send out disease.
Multinomial zoopery and clinical trial show, chromium is the insulin required cofactor that plays a role, and it combines with insulin, and strengthens insulin action comprehensively, obviously improves glucose tolerance, and effective blood sugar lowering.Trivalent chromium is the trace element of needed by human, wherein three chromium picolinates be safely, the form that is easily absorbed by the body, United States Patent (USP) 4,315,927 have announced when giving the synthetic chromium picolinate coordination complex of administration external source, they directly are absorbed, and do not compete with other metals, and these complex safety, cheapness, biology can tolerate and be easy to preparation.United States Patent (USP) 5,087 has been described in the 623 disclosed technology and has been used three chromium picolinates and treat type ii diabetes, and every day is with three chromium picolinates, 50～500 μ g treatment type ii diabetes.Above-mentioned two patents all only adopt the agent of individual event trivalent chromium to replenish, and the unresolved most important reason that causes type ii diabetes, promptly owing to the age increases the fat insulin resistant that is caused in back, and then the hyperglycemia of re-initiation companion hyperlipidemia situation.
The scientist Drs.Isidori of foreign country, A., (Isidori, A., et al.Current Medical Research and Opinion (1981): 475-481). confirm, the aminoacid of special combination after intestinal attracts, can be induced the human growth hormone secretion increasing through the oral cavity, and the aminoacid of intravenous injection specific combination can intense stimulus hypophysis cerebri growth hormone releasing.Franco Salomon et al[The New England Journal of Medicine vol.321 (26) p.1797-1803 1989] carried out being provided with in six months matched group, double blinding clinical trial, adopt recombinant human growth hormone to treat the patient that 24 individual inner growth hormones lack, the result confirms that the intravital insulin like growth factor of experimenter (IGF-1) secretion increases, lose weight, fat reduces, the organism metabolism rate increases, and plasma cholesterol reduces.J.O.L.Jorgensen et al (Lancet--Jun.3.sup.rd, 1989p.1221-1225) patient of 22 growth hormone deficiency is carried out the clinical trial of four months injection growth hormone, proof experimenter's muscle thickness increases, fat reduces, renal blood flow increases, and glomerular filtration rate increases.Rudman D.et al[TheNew England Journal of Medicine 322 (1990): 1-6] show that 12 ages are at the healthy male between 61-81 year, after through human growth hormone injection in 6 months, muscle increases, fatty tissue reduces, its effect is equivalent to the age and reduces 10-20 year, Dr.Rudman points out, because the health component that our age growth causes changes, can reverse by the method that increases level of growth hormone.
Above-mentioned evidence shows, can increase the human muscle by stimulating human growth hormone to discharge, and reduces fat, reduce the body inner cholesterol, and the aminoacid of specific combination can stimulate the human body hypophysis cerebri to discharge more growth hormone, and human body inner growth hormone content is improved.Human growth hormone can reduce abdominal part, buttocks, waist, huckle fat by selectivity, increases muscle, and clinical trial shows, through six months growth hormone therapies, on average increases muscle 8.8%, reduces fat 14.4%.Clinical trial shows that oral arginine and lysine increase the growth hormone release that Ren Ti Nei stores deposits, and has both made low dosage arginine (200mg) also can improve human growth hormone and has discharged.Human growth hormone is in case discharge from hypophysis cerebri, can stimulate liver to produce insulin like growth factor (IGF-1), and after insulin like growth factor (IGF-1) enters blood circulation, can stick to cell membrane, similar ILA takes place, blood sugar lowering increases glucose metabolic process in vivo.
Clinical trial also shows, behind the oral free aminoacid, insulin content obviously increases in the body, a zoopery shows, behind oral free aminoacid, plasma insulin level is increased to 6 milli More/L from 2 milli More/L, the increase degree reaches 3 times, because aminoacid can more effectively stimulate the beta Cell of islet uelralante.
Technical problem to be solved by this invention is by the compositions of safety, nontoxic pair of effect is provided, improving the old fat glycometabolic while of type ii diabetes human blood, improve lipid metabolism, help the patient to lose weight, improve insulin sensitivity, reduce insulin resistant.
Summary of the invention:
The technical scheme that the present invention solves its technical problem to be provided is, the combination preparation of multiple free amino acid and three chromium picolinates is provided by various ways, to replenish the trivalent chromium that the diabetes patient is lacked, increase the intravital glucose tolerance factor quantity of people, increase glucose bioavailability in vivo, stimulate beta Cell of islet to discharge more insulin simultaneously, stimulate human growth hormone to discharge, increase muscle strength, reduce body fat content, improve blood lipid metabolism in the body, and indirect stimulation insulin like growth factor (IGF-1) release, the blood glucose metabolism further improved.By using the combinations thereof preparation, to reduce insulin resistant, increasing insulin discharges, increase the insulin bioavailability and increase insulin sensitivity, increase lipid metabolism and conversion, reduce cholesterol in the blood, blood fat reducing in blood sugar lowering, fundamentally stop the development of diabetes, stop or delay the generation that diabetes And sends out disease.
Comprise following free amino acid (also can use the amino acid replacement of levorotatory form) in the several amino acids compositions that compositions moderate stimulation human growth hormone of the present invention discharges and the increase insulin discharges: lysine, ornithine, glutamine, glycine, leucine, isoleucine, valine, arginine.Replenish human glucose tolerance factor constituent-trivalent chromium in the compositions of the present invention simultaneously, be used for human body simultaneously with the form and the above-mentioned amino acid composition of three chromium picolinates.The present composition gives patient's dosage every day:
(1) 1200mg aminutrin
(2) 1200mg L-arginine
(3) the left-handed ornithine of 800mg
(4) 500mg glycine
(5) the left-handed glutamine of 250mg
(6) 400mg leucine
(7) 400mg isoleucine
(8) 400mg valine
(9) 500 μ g three chromium picolinates
The dosage of supply present composition every day can be in following scope:
(1) lysine 500mg～1500mg
(2) arginine 500mg～1500mg
(3) ornithine 500mg～1500mg
(4) glutamine 200mg～1000mg
(5) glycine 400mg～1000mg
(6) leucine 400mg～1000mg
(7) isoleucine 400mg～1000mg
(8) valine 400mg～1000mg
(9) three chromium picolinates 50 μ g～1000 μ g
Aminoacid composition in the above-mentioned composition can be by stimulating patient's hypophysis cerebri growth hormone releasing, inject the effect that expensive recombinant human growth hormone just can reach and reach common needs, the method of this promotion self secretion growth hormone has kept the circulation of self growth hormone feedback release, can not only reach the purpose of nature growth hormone releasing, and mode is safer, more meet human body physiological state, still less pay effect, and this promotion pattern of secreting growth hormone naturally can be imitated more than other various possible treatment patterns at present and impelled human growth hormone performance vivo effect.
Some aminoacid can be synthetic by body self, but some essential amino acids human body self can not synthesize, must from food, absorb, a kind of so just essential amino acids of arginine, arginine not only can increase muscle strength, can also promote fat combustion, and improve immune function of human body by increasing thymic weight and activity.
Arginine and lysine synergism have been proved to be and can promote human growth hormone to discharge, and lysine can not only improve arginic useful effect, also can help to improve simultaneously autoimmune function, promotes the body rehabilitation.
Ornithine can be synthesized by body, equally also is proved to be to help the stimulating growth hormone to discharge.
Glutamine can be synthesized by body too, but under body was in pressure state, its synthetic quantity can not satisfy the demand of body, if can not reach enough quantity, the body digestive tract can not works fine, and nutrition can not be absorbed well.
Other aminoacid in the present composition all have good synergism with above-mentioned aminoacid, unite use with above-mentioned aminoacid and can bring into play better effect.
Lysine, glutamine, ornithine and arginine can reduce insulin resistant by the content that improves the body inner growth hormone in the above-mentioned amino acid whose compositions, zoopery and clinical trial prove, when intravital level of growth hormone improved, insulin resistant obviously reduced.The effective blood sugar lowering of glutamine in the present composition, and reduce insulin resistant by increasing the insulin bioavailability, and ornithine associating glutamine can cholesterol recover the blood lipid metabolism balance in the blood by reducing.The aminoacid by oral route supply human body of above-mentioned multiple associating, energy effective stimulus beta Cell of islet uelralante is strengthened glycemic control.
Three chromium picolinates in the present composition are the easiest trivalent chromium preparations that are absorbed by the body of generally acknowledging at present, chromium is the trace element that necessary for human body has nutritive value, clinical research is found, often seriously lack chromium in the old fat type ii diabetes human body, and the chromium element is the constituent of human glucose tolerance factor, it is the insulin necessary cofactor that plays a role, it combines with insulin, can increase insulin sensitivity, reduce insulin resistant, blood sugar regulation metabolism and blood lipid metabolism.It is 50 μ g～200 μ g that the trivalent chromium day that AAN is recommended is replenished dosage, the investigation proof, the daily chromium that from diet, only can replenish 20 μ g～30 μ g of majority, and have the old fat type ii diabetes people of insulin resistant phenomenon because insulin compensatory secretion increasing, and need be than normal more chromium element, this also is the reason that a lot of type ii diabetes people use orally-taken blood sugar reducing medicine poor effect.
Clinical trial shows, replenish the trivalent chromium of low dosage every day, if dosage is lower than 200 μ g/ days, the blood sugar lowering DeGrain, and more clinical trial shows, three chromium picolinates that replenish 400 μ g～500 μ g every day can reduce insulin resistant effectively, reduce glycolated hemoglobin (HBA1C) and reach 20%～30%.
Old obese type type ii diabetes people is because the internal metabolism disorder, alimentation is unbalanced, often lack various essential amino acids or non essential amino acid simultaneously, and carbohydrate metabolism and lipid metabolism is simultaneously in the chromium element is coordinated the insulin control agent, need to consume a lot of essential amino acids or non essential amino acid, therefore when effectively replenishing trivalent chromium, additional part plays an active part in the aminoacid of insulin metabolism, helps both sides to bring into play bigger synergism.
Giving the several amino acids combination additional simultaneously three chromium picolinates in the compositions of the present invention, give the synergism that can provide bigger separately than two kinds of components, and two kinds of compositionss can be replenished deficiency separately mutually, blood glucose metabolism and blood lipid metabolism in the collaborative control agent, promote insulin secretion, reduce insulin resistant, increase insulin action.
The specific embodiment:
One of embodiment of the present invention is to help the old fat type ii diabetes patient blood sugar lowering and the method for blood fat, this method comprises to the patient unites use with various independent composition preparations, or use for the patient: lysine 500mg～1500mg as the preparation of compositions unitary agent, arginine 500mg～1500mg, ornithine 500mg～1500mg, glutamine 200mg～1000mg, glycine 400mg～1000mg, leucine 400mg～1000mg, isoleucine 400mg～1000mg, three chromium picolinates, 50 μ g～1000 μ g.
Two of embodiment of the present invention is to series preparation use in conjunction under the patient: arginine 500mg～1500mg, three chromium picolinates, 200 μ g～1000 μ g.
Three of embodiment of the present invention is to series preparation use in conjunction under the patient, or use for the patient: aminutrin 1500mg as the preparation of compositions unitary agent, left-handed ornithine 1200mg, glycine 500mg, left-handed glutamine 250mg, leucine 400mg, isoleucine 400mg, valine 400mg, three chromium picolinates, 400 μ g.
Four of embodiment of the present invention is to unite use to series preparation under the patient, or uses for the patient as the preparation of compositions unitary agent: L-arginine 1200mg, three chromium picolinates, 500 μ g.
Five of embodiment of the present invention is to unite use to series preparation under the patient, or uses for the patient as the preparation of compositions unitary agent: lysine 1000mg, arginine 1000mg, left-handed glutamine 250mg, three chromium picolinates, 500 μ g.
Aspect another of above-mentioned embodiment, above-mentioned free amino acid is present in the pharmaceutical carrier, and three chromium picolinates also are present in the pharmaceutical carrier.
The present invention also provides and has contained in the above-mentioned embodiment a plurality of free amino acids as a compositions, the preparation unitary agent, and three chromium picolinates allow the patient unite use as another preparation.
The preparation of compositions method:
Above-mentioned all kinds of free amino acids among the present invention can be bought from how tame biopharmaceutical company, and also the method that can adopt dawn plain boiled water to separate prepares in vain by the white enzyme hydrolysis dawn at dawn from the high-quality dawn such as the cheese dawn is white, the Semen sojae atricolor dawn is white are white, and preparation method is known method.
The synthetic method of three chromium picolinates, open in United States Patent (USP) (US5,087,623), three chromium picolinates can be bought commercial prod in how tame drugmaker.
For the oral administration form, in the above-mentioned embodiment all kinds of free amino acids and three pyridine carboxylic acid cheese can be with tablet, aqueous or oil-based suspension, can disperse powder or granule, emulsion, hard or soft capsule, syrup or elixir to provide.Being used for oral compositions can prepare according to the known any way in preparation Pharmaceutical composition field, and these compositionss can contain one or more following reagent: sweeting agent, correctives, coloring agent and antiseptic.Sweeting agent and correctives can increase the palatability of preparation.
In tablet manufacture, can adopt pharmaceutical excipient, these excipient comprise inert diluent such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; Granulating agent and disintegrating agent are as Semen Maydis powder or alginic acid; Binding agent such as starch, gelatin or arabic gum; Lubricant such as magnesium stearate, stearic acid or Talcum.Tablet can be that no coating maybe can be by the known technology coating so that postpone in gastrointestinal tract disintegrate and absorption, therefore and provide slow releasing function in a long time, for example, time of application postpones material such as glyceryl monostearate or glycerol distearate or share with vinegar separately.Oral formulations can be a snap fit capsule, and wherein active constituent mixes with the agent of inertia fixed dilution such as calcium carbonate, calcium phosphate or Kaolin, also can be gelatin soft capsule, wherein active constituent and water or oily medium such as Oleum Arachidis hypogaeae semen, liquid paraffin or mixed with olive oil.
Aqueous suspension can contain free amino acid combination of the present invention or three chromium picolinates and be suitable for preparing the excipient of aqueous suspension, and these excipient comprise suspending agent, dispersant, wetting agent, antiseptic, coloring agent, correctives, sweeting agent such as sweet taste chrysanthemum etc.
The oiliness suspensoid can be by being suspended in active constituent vegetable oil such as Oleum Arachidis hypogaeae semen, olive oil, Oleum sesami or Oleum Cocois, or prepare in mineral oil such as liquid paraffin.This oiliness suspensoid can contain thickening agent, as Cera Flava, hard paraffin or spermol etc.Can add aforesaid sweeting agent and correctives so that good to eat oral formulations to be provided.These compositionss can be anticorrosion by adding antioxidant such as ascorbic acid.
Powder and the granule of disperseing of the present invention, it is suitable for preparing aqueous suspension by adding entry, contain active constituent and dispersant or wetting agent, suspending agent and one or more antiseptic, can also have other excipient, for example sweeting agent, correctives and coloring agent.
Can use sweeting agent such as glycerol, sorbitol or sucrose syrup blend or elixir.These preparations can also contain demulcen, antiseptic, correctives or coloring agent.
Can mix several amino acids combination/three chromium picolinates that prepare single dose form with medicinal carrier substance, its dosage can change according to object of being treated and specific form of medication.
Compositions of the present invention is to assist the more growth hormone of human secretory as a kind of form of supplementary by the nutritional labeling of replenishing needed by human, insulin like growth factor, and work in coordination with insulin and in the blood sugar regulation metabolism, act on by replenishing human glucose metabolism trace elements necessary, this is undoubtedly fool proof and more near the Human Physiology pattern, the more acceptable mode of patient, the essence of this mode is that compliance is regulated rather than the circulation of mandatory blocking-up physiology, so the effect that this mode is brought into play needs certain hour just can reach good result, at least should take more than three months,, obtains the while bigger effect if with dietary adjustments and motion, then working in coordination with.Present studies show that, the patient continues to take and can bring maximum efficiency, and the ideal mode of taking of the present invention is with tablet or capsule,, is preferably taking on an empty stomach through gastrointestinal absorption by oral, can be by bigger absorption.
Compositions of the present invention is applicable to that all kinds of noninsulindependent diabetes (being type ii diabetes) patient is used for assist control blood glucose and blood fat, and helps to lose weight, and reduces athero, prevents that And from sending out disease; Be applicable to that carbohydrate tolerance is bad, the diabetes that post-prandial glycemia raises are easily sent out crowd's prevent diabetes; Can be applicable to X-metabolic syndrome crowd simultaneously and be used for losing weight, reduce developing of diabetes and cardiovascular disease; And be suitable for old obese type patient and prevent diabetes.The optimal application adaptation disease of the present composition is old obese type type ii diabetes people.
The invention has the beneficial effects as follows that stimulation human body inner growth hormone discharges by replenishing the needed by human nutritional labeling, increase the human body metabolism and reduce the body fat accumulation, lose weight.Promote insulin to bring into play more effective effect simultaneously, reduce insulin resistant, increase insulin sensitivity and bioavailability, effective blood sugar regulation and blood lipid metabolism, taking safety, do not have any poison and pay effect, is the good nutrition supplement of type ii diabetes prevention and treatment
The invention will be further described below in conjunction with example:
Embodiment
The complex capsule of present composition preparation is used for clinical trial.20 type ii diabetes people are carried out the randomized, double-blind clinical experiment, patient's every day of 1/2nd the oral present composition complex capsule, contain the 1000mg arginine every day in the dosage, 1000mg lysine, the left-handed glutamine of 250mg, 500 μ g, three chromium picolinates (are taken 5 complex capsules every day, every capsule includes arginase 12 00mg, lysine 200mg, glutamine 50mg, three chromium picolinates, 100 μ g).Other 1/2nd take placebo, took 6 months by above-mentioned dosage, measure glycolated hemoglobin (HBA1C) when this experiment begins and finishes respectively and weigh in, after this experiment finishes, the patient who takes the present composition, glycolated hemoglobin on average reduces by 15%, lose weight 8%, on the contrary, take the patient of placebo every day, the change of above-mentioned parameter does not have statistical significance.
Claims (9)
1. one kind is passed through to replenish the nutritional labeling reduction blood sugar for human body of needed by human and the method for blood fat, this method comprises to using lysine 500～1500mg with the free amino acid form the individual every day of needs, arginine 500～1500mg, ornithine 500～1500mg, glutamine 200～1000mg, glycine 400～1000mg, leucine 400～1000mg, isoleucine 400～1000mg, valine 400～1000mg, unite simultaneously the trivalent chromium of using 50 μ g～1000 μ g with the form of synthetic three chromium picolinates every day, the multiple free amino acid of wherein being selected jointly and the amount of three chromium picolinates can provide play a part than adduction bigger.
2. according to the method for claim 1, comprise and use aminutrin 1200mg with the free amino acid form every day, L-arginine 1200mg, left-handed ornithine 800mg, glycine 500mg, left-handed glutamine 250mg, leucine 400mg, isoleucine 400mg, valine 400mg uses trivalent chromium 500 μ g with synthetic three chromium picolinate forms.
3. according to the method for claim 1, comprise and use arginine 500mg～1500mg with the form of free amino acid every day, best dosage range is 800～1000mg, uses trivalent chromium 200 μ g～1000 μ g with synthetic three chromium picolinate forms, and best dosage range is 300～500 μ g.
4. according to the method for claim 1, comprise and use aminutrin 1500mg with the free amino acid form every day, left-handed ornithine 1200mg, glycine 500mg, left-handed glutamine 250mg, leucine 400mg, isoleucine 400mg, valine 400mg uses trivalent chromium 400 μ g with synthetic tricarboxylic acid pyridine chromium form.
5. according to the method for claim 1, comprise and use L-arginine 1200mg with the form of free amino acid every day, use trivalent chromium 500 μ g with synthetic tricarboxylic acid pyridine chromium form.
6. according to the method for claim 1, comprise and use lysine 1000mg with the free amino acid form every day, arginine 1000mg, left-handed glutamine 250mg uses trivalent chromium 500 μ g with synthetic three chromium picolinate forms.
7. according to the method for claim 1, above-mentioned free amino acid may reside in the pharmaceutical carrier, and three chromium picolinates also may reside in the pharmaceutical carrier, use in the oral administration mode.
8. according to the method for claim 1, above-mentioned free amine group acid constituents and three chromium picolinate components can mix the compositions for preparing single dose form with medicinal carrier substance.
9. according to the method for claim 1, the compositions of above-mentioned free amino acid and three chromium picolinates, co-administered according to above-mentioned application dosage scope, can not only promote human growth hormone to discharge, tone up the muscles, reduce fat, improve lipid metabolism, can also strengthen glucose tolerance factor, increase insulin sensitivity, reduce insulin resistant, thereby effective blood sugar lowering improves the blood glucose metabolism.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101649004B (en) * | 2009-09-18 | 2012-08-22 | 中国海洋大学 | Marine oligosaccharide compound with type II diabetes resisting activity and preparation method thereof |
| EP2429536A4 (en) * | 2009-05-14 | 2012-10-24 | Pharmachem Lab Inc | L-arabinose plus chromium for controlling the metabolization of sucrose |
| CN106267165A (en) * | 2016-08-29 | 2017-01-04 | 楼秀余 | HGH and IGF 1 liposome complex capsule and preparation method thereof |
| CN112022874A (en) * | 2020-07-01 | 2020-12-04 | 国际批发集团有限公司 | Oral nicotinamide adenine dinucleotide precursor oral supplement formulations that support physiological functions associated with human aging |
| JP2021527671A (en) * | 2018-06-20 | 2021-10-14 | アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． | Compositions and Methods for Relieving or Treating Insulin Resistance and Metabolic Disorders |
-
2004
- 2004-01-15 CN CNA2004100158666A patent/CN1557301A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2429536A4 (en) * | 2009-05-14 | 2012-10-24 | Pharmachem Lab Inc | L-arabinose plus chromium for controlling the metabolization of sucrose |
| EP2857022A1 (en) * | 2009-05-14 | 2015-04-08 | Pharmachem Laboratories, Inc. | L-arabinose plus chromium for controlling the metabolization of sucrose |
| CN101649004B (en) * | 2009-09-18 | 2012-08-22 | 中国海洋大学 | Marine oligosaccharide compound with type II diabetes resisting activity and preparation method thereof |
| CN106267165A (en) * | 2016-08-29 | 2017-01-04 | 楼秀余 | HGH and IGF 1 liposome complex capsule and preparation method thereof |
| JP2021527671A (en) * | 2018-06-20 | 2021-10-14 | アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． | Compositions and Methods for Relieving or Treating Insulin Resistance and Metabolic Disorders |
| CN112022874A (en) * | 2020-07-01 | 2020-12-04 | 国际批发集团有限公司 | Oral nicotinamide adenine dinucleotide precursor oral supplement formulations that support physiological functions associated with human aging |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |