CN1233377C - Fat reducing Chinese drugs for treating simple obesity - Google Patents
Fat reducing Chinese drugs for treating simple obesity Download PDFInfo
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- CN1233377C CN1233377C CN 03135231 CN03135231A CN1233377C CN 1233377 C CN1233377 C CN 1233377C CN 03135231 CN03135231 CN 03135231 CN 03135231 A CN03135231 A CN 03135231A CN 1233377 C CN1233377 C CN 1233377C
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Abstract
The present invention relates to weight-losing traditional Chinese medicine for treating simple obesity, which is mainly prepared by refining the following raw material according to requirements for each preparation: 20 to 40 parts of lotus leaves, 10 to 30 parts of hawthorns, 10 to 30 parts of semen cassiae, 10 to 30 parts of tea and 10 to 30 parts of honeysuckle flowers. A plurality of kinds of medicine are used together in the formula of the present invention, and the several kinds of the medicine support each other and supplement each other. The trial of people which lose weight for a long time shows that the present invention is easy to accept, due to the characteristic of the integration of medicine and food, the present invention has an obvious effect on losing weight, and the present invention has no toxicity and no side effect after the medicine is taken for a long time. The preparation of the present invention comprises tablets, granule, pills, capsules and oral liquid.
Description
Affiliated technical field: the invention belongs to the field of Chinese medicines, specifically is a kind of fat-reducing Chinese medicine for the treatment of Simple Obesity.
Background technology: along with the progress of society and the raising of people's living standard, the minimizing of activity in addition, Fei Pang crowd is more and more in recent years, and various slimming medicines also appear on the market one after another, but the medicine that fat-reducing effect is good, side effect is little, the retention time is long is very few.
The objective of the invention is provides the fat-reducing Chinese medicine of the treatment Simple Obesity that a kind of fat-reducing effect is good, side effect is little, the retention time is long in order to satisfy the demand of society for people.
The objective of the invention is to realize by following technical proposals.
Summary of the invention: the fat-reducing Chinese medicine of treatment Simple Obesity of the present invention, main raw material by following prescription: Folium Nelumbinis 20-40 part, Fructus Crataegi 10-30 part, Semen Cassiae 10-30 part, Folium Camelliae sinensis 10-30 part are refined into tablet, granule, pill, capsule or oral liquid by each dosage formulation requirement.
In the such scheme, also can add Flos Lonicerae 10-30 part.
Technical scheme of the present invention be the inventor according to motherland's Chinese medical theory, and the development of the practice summary by for many years gets.Prescription of the present invention is made up of Folium Nelumbinis, Fructus Crataegi, Folium Camelliae sinensis, Semen Cassiae, Flos Lonicerae, and flavour of a drug all are that medicine is eaten shared raw material, wide material sources, and edible safety, Folium Nelumbinis GUIXIN, liver, spleen, stomach warp in the prescription can summer heat relieving and dampness eliminatings, sending up the lucid YANG and dissipating blood stasis; Modern scientific research proves, contained nuciferine in the Folium Nelumbinis is to quicken the lipid metabolism material, and human body is had clear and definite fat-reducing and antihyperglycemic; The Fructus Crataegi stagnant eliminate indigestion that then can disappear share with green tea, common function of spleen and stomach regulating function, and relieving dyspepsia promotes intestinal to drain food stagnation; Semen Cassiae has the effect that makes eye bright, prevents and treats hypertension, hyperlipemia and constipation; Flos Lonicerae has the effect of heat-clearing and toxic substances removing.The all medicines of prescription of the present invention share, and mutually support, replenish mutually, through long-term people to lose weight back on probation proof, be easy to accept, and because of we with the medicine food together with being characteristics, its antiobesity action is obvious, eats without any side effects for a long time.
Product forms of the present invention has tablet, granule, pill, capsule, oral liquid.Name of product of the present invention can be beautiful image fat-reducing sheet or the beneficial body sheet etc. of gently losing weight.
The specific embodiment:
Embodiment one
Get 30 parts on Folium Nelumbinis, 20 parts of Fructus Crataegis, 20 parts of Semen Cassiaes, 20 parts of Folium Camelliae sinensis, above-mentioned primary crude drug mixture is decocted, each 100kg medical material adds the drinking water of 1000L approximately, soak about 30min for the first time and boil, decoct three times, each 45～70 minutes, get medicinal liquid; After the filtration of reuse 200 mesh sieves, concentrate with the energy-conservation concentrator of triple effect, one imitates 80 ℃ of temperature, two 70 ℃ of effects, 60 ℃ of triple effects, is concentrated into relative density 1.14～1.18, gets clear paste; Get the powder process of moiety clear paste spray drying, 160～180 ℃ of inlet temperature, 80～100 ℃ of leaving air temps get extract powder; Remaining second half clear paste and extract powder are granulated with one-step-granulating method, and 60～80 ℃ of inlet temperature, 45～70 ℃ of leaving air temps get granule, are distributed into 3000 bags, and every bag of 6g gets the granule product; Also can go into capsule and make capsule, every 0.4g, 45000 particles filled.
Embodiment two
Get 20 parts on Folium Nelumbinis, 10 parts of Fructus Crataegis, 10 parts of Semen Cassiaes, 10 parts of Folium Camelliae sinensis, above crude drug 100kg, be processed into granule by the method for embodiment one after, add the proper amount of lubricating agent tabletting again, every 0.48g～0.52g, high-efficiency coating machine coating, be distributed into 300 bottles, 36 every bottle, get the tablet product.
Embodiment three
With 40 parts on Folium Nelumbinis, 30 parts of Fructus Crataegis, 30 parts of Semen Cassiaes, 25 parts of Folium Camelliae sinensis, above-mentioned pulverizing medicinal materials becomes fine powder, sieve, and mixing, adding Mel and an amount of water system soft material, general ball, cold drying, packing on general ball machine get the pill product.
Embodiment four
Get 25 parts on Folium Nelumbinis, 15 parts of Fructus Crataegis, 25 parts of Semen Cassiaes, 15 parts of Folium Camelliae sinensis, above-mentioned primary crude drug mixture is decocted, each 100kg medical material adds the drinking water of 1000L approximately, soak about 30min for the first time and boil, decoct each 45～70 minutes three times, collect volatile oil simultaneously, get medicinal liquid; 200 mesh sieves filter the back and are concentrated into every 1ml medicinal liquid with the energy-conservation concentrator of triple effect and are equivalent to crude drug 2g, put coldly, and adding ethanol to the concentration of alcohol of medicinal liquid is 50～70%, the precipitate with ethanol remove impurity stirs evenly, and places 24h and filters, filtrate recycling ethanol is not to there being the alcohol flavor, and the water dilution with an amount of filters, add dosings such as various additives, filter, embedding is in the control oral liquid bottle, every bottle of 10ml with 100 ℃ of sterilization 30min, is distributed into 2000 boxes, 10 in every box promptly gets oral liquid.
Embodiment five
Get 35 parts on Folium Nelumbinis, 25 parts of Fructus Crataegis, 15 parts of Semen Cassiaes, 15 parts of Folium Camelliae sinensis, above-mentioned primary crude drug become granule by the method preparation of embodiment one, packing, granule.
Embodiment six
Get 25 parts on Folium Nelumbinis, 18 parts of Fructus Crataegis, 20 parts of Semen Cassiaes, 22 parts of Folium Camelliae sinensis, 20 parts of Flos Loniceraes are prepared into granule by the method for embodiment one, packing, the granule product.
Embodiment seven
30 parts on Folium Nelumbinis, 15 parts of Fructus Crataegis, 12 parts of Semen Cassiaes, 15 parts of Folium Camelliae sinensis after 10 parts of methods by embodiment one of Flos Lonicerae are processed into granule, add the proper amount of lubricating agent tabletting again, the high-efficiency coating machine coating, and packing gets the tablet product.
Embodiment eight
With 25 parts on Folium Nelumbinis, 15 parts of Fructus Crataegis, 15 parts of Semen Cassiaes, 12 parts of Folium Camelliae sinensis, 12 parts of Flos Loniceraes are ground into fine powder, sieve, and mixing, add Mel and make soft material with an amount of water, use the pellet processing machine pill, and cold drying, packing must the pill products: the 100g/ bottle.
Further specify beneficial effect of the present invention below by clinical data.
Product fat-reducing human feeding trial laboratory report situation of the present invention:
1, material and method:
1.1 sample: product of the present invention is the light green tablet, every net weight 0.5 gram.Product human body recommended amounts is: everyone every day 3 times, each 6, promptly 9 restrain for each person every day; Be equivalent to 60kg body weight adult 0.15 gram/kg body weight for each person every day.
1.2 experimenter group: select to meet following standard person by the principle of voluntariness and participate in into the body test-meal as the experimenter and test.
1.2.1 experimenter's choice criteria: select the age more than 18 years old, Simple Obesity person, the body weight body weight 20% that is above standard.The standard body weight computing formula is: standard body weight kg=(height cm-100) * 0.9; Overweight degree %=(body weight kg-standard body weight kg) * 100/ standard body weight kg.
1.2.2 exclusion standard: experimenter's blood glucose overrun; Get rid of gallbladder disease.
1.3 experimental design: undertaken by fat-reducing human feeding trial method in " the health food function assessment assessment process and the method for inspection " regulation of Ministry of Public Health health supervision department promulgation in 1996.The experimenter adopts self-controlled method, body weight before and after relatively the experimenter tests, the variation of indexs such as body fat content.
1.4 taking dose and time: everyone each oral 6 of experimenters, every day 3 times, eliminating cold for resuscitation water is taken, no fasting requirement during being tried, be 5 weeks observing time.
1.5 key instrument:
1.5.1 body fat content: the bio-electrical impedance instrument (RJL-systems, BIA101, Detroit, USA); The pick up pincers (HoLtainLd, Crymych, dyfed, UK); Exercise tolerance: cycle ergometer (Monark 818E, VarbergSweden).
1.5.2 the clinical health check-up of experimenter: entrust Xiyuan, Beijing hospital to carry out blood, urine biochemistry that the experimenter tests front and back, and B ultrasonic, the Chest X-rays of X-line, project health check-ups such as electrocardiogram.
1.6 observation index:
1.6.1 ordinary circumstance: the experimenter is in duration of test mental status, diet situation, sleep quality, defecation situation.
1.6.2 safety is observed: the blood routine inspection: red blood cell count(RBC), numeration of leukocyte, hemoglobin detect.Blood biochemistry index is measured: serum albumin ALB, total protein TB, glutamate pyruvate transaminase ALT, blood glucose GLU, blood fat (T-CHOL TC, triglyceride TG, high density lipoprotein level HDL-C), blood uric acid, urine ketoboidies.The Chest X-rays of X-line, Abdominal B type ultrasonography (liver, gallbladder, pancreas, spleen, kidney), electrocardiogram.
1.6.3 effect observation index: body weight, body fat weight, body fat percentage composition, subcutaneous fat thickness (four positions), waistline (umbilicus week), hip circumference.Body fat content: use the bio-electrical impedance instrument to measure body fat content.Use the pick up pincers to measure four position skinfolds of regulation in " program and method ".When using cycle ergometer to measure experimenter's exercise tolerance, predetermined movement power is: 100 watts of women (being equivalent to 2kg/50 rev/min); 120 watts of male (being equivalent to 2kg/60 rev/min).(Sport tester, PE3000 Fenland), write down 5 minute campaign hearts rate, infer maximal oxygen consumption to use remote measurement heart rate monitor.
1.7 experimental data statistics: use Microsoft Excel7.0 calculate the experimenter test before and after the average and the standard deviation of every index, and result before and after the test matched the T-check.When the P value less than 0.05, think to have significant difference.
2, result:
2.1 ordinary circumstance: 30 experimenters, the mean age is 43.13 ± 13.29 years old; Height 161.60 ± 7.91cm; Body weight 78.28 ± 14.26kg; Overweight degree is 17.42 ± 12.20.Duration of test experimenter spirit is normal, all no abnormal performance of diet, sleep, defecation: Chest X-rays, electrocardiogram no abnormality seen.
2.2 safety observation index:
2.2.1 situation of change before and after the routine blood test test
Tried thing as seen from Table 1 experimenter's erythrocyte, leukocyte, hemoglobin all are in normal range, significantly do not changed before and after the test.
Routine blood test index before and after table 1 test
| Number | Erythrocyte (10 12/L) | Leukocyte (10 9/L) | Hemoglobin (g/L) | |
| After testing before the experiment | 30 30 | 4.91±0.61 4.87±0.51 | 6.51±1.75 6.24±1.49 | 139.30±15.29 137.90±13.76 |
| Normal value | 4.3-5.4 | 4.1-10.0 | ＞120.0 |
2.2.4 situation of change before and after the test of plasmacule index
Blood glucose, ALT, total protein, albumin, uric acid all were in normal range before and after the experimenter tested; The urine ketoboidies is negative; Blood fat is in normal range, and T-CHOL, triglyceride have reduction trend.
Blood biochemistry index before and after table 2 test
| Number | T-CHOL mmol/l | Triglyceride mmol/l | HDL mmol/l | Blood glucose mmol/l | ALT U/L | Total protein g/L | Albumin g/L | Uric acid mol/l | |
| After testing before the experiment | 30 30 | 5.31±0.93 5.15±1.03 | 2.11-1.89 2.19±1.37 | 2.03±1.36 1.29±0.25 | 5.26±1.96 4.99±1.47 | 31.9±24.0 27.1±15.1 | 75.2±4.4 73.9±4.8 | 45.6±8.0 46.9±2.3 | 343.7±91.4 323.2±90.9 |
| Normal value | 3.1-5.7 | 0.6-1.7 | 1.09-2.06 | 3.9-6.1 | 0-40 | 60-82 | 35-55 | 90-440 |
The endurance situation of change 2.2.3 test seesaws
Table 3 is tested the endurance situation that seesaws
| Number | Maximal oxygen consumption (L/ branch) | |
| After testing before the experiment | 30 30 | 2.9±0.3 2.7±0.2 |
| Difference | -0.2±0.1 |
2.3 effect index result
2.3.1 body weight and body fat situation of change before and after the test
The experimenter tests back body weight, body fat content, body fat percentage composition and obviously reduces P＜0.01 before the test.Illustrate the experimenter take tried thing after body fat obviously reduce.
Body weight and body fat situation before and after table 4 test
| Number | Body weight (kg) | Body fat content (kg) | Body fat percentage composition (%) | |
| After testing before the experiment | 30 30 | 78.28±14.50 76.17±14.22 | 25.52±5.44 24.24±5.33 | 32.74±4.87 31.98±5.18 |
| Difference | 2.11±1.59 ** | 1.28±1.56 ** | 0.75±1.67 * |
*: pairing T check before and after the experiment, P＜0.01;
*: P＜0.05 has statistics word significance.
2.3.2 subcutaneous fat thickness and girth diameter situation of change before and after the test
The experimenter tests two position subcutaneous fat thicknesses on the other and ilium ridge of posterior umbilicus, and waist, hip circumference obviously reduce P＜0.01 before testing.Illustrate that the experimenter tests the back subcutaneous fat and reduces.
Subcutaneous fat thickness, waistline and hip circumference index before and after table 5 test
| Number | Subcutaneous fat thickness (mm) | Girth diameter (cm) | |||||
| Triangular muscle | Under the omoplate | The other 3cm of umbilicus | On the ilium sour jujube | Waistline | Hip circumference | ||
| After testing before the experiment | 30 30 | 49.4±14.3 46.8±13.7 | 47.5±9.45 45.2±9.2 | 56.7±13.5 52.2±12.8 | 44.4±10.9 41.7±11.1 | 96.1±9.8 93.1±9.7 | 109.4±7.7 107.5±7.5 |
| Difference | 2.58±3.3 ** | 2.33±3.4 ** | 4.53±4.75 ** | 2.7±3.8 ** | 2.97±3.02 ** | 1.93±1.94 ** | |
*: pairing T check before and after the experiment, P＜0.01 has significance,statistical.
3, brief summary
30 routine Simple Obesity experimenters take product of the present invention on request, weight average after 5 weeks
Decline 2.11 ± 1.59kg, body fat content decline 1.28 ± 1.56kg, body fat percentage composition descends 0.75 ± 1.67, and test front and back self T-checks has significance,statistical (P＜0.01).And the subcutaneous fat thickness under waist, hip circumference and triangular muscle, the omoplate on umbilicus side and the crista iliaca all has remarkable minimizing (P＜0.01).Experimenter's erythrocyte, leukocyte, hemoglobin, total serum protein, albumin, glutamic oxaloacetic transaminase, GOT, blood uric acid, urine ketoboidies all are normal range before and after the test, and exercise tolerance does not have significant change.Illustrate that grace prestige board beautiful image fat-reducing sheet is to not obviously influence of body health.According to the criterion in " the health food function assessment assessment process and the method for inspection " of Ministry of Public Health promulgation, think that grace prestige board beautiful image fat-reducing sheet has antiobesity action.
Claims (2)
1. fat-reducing Chinese medicine for the treatment of Simple Obesity, it is characterized in that it is a raw material by following weight portion: 20～40 parts on Folium Nelumbinis, 10～30 parts of Fructus Crataegis, 10～30 parts of Semen Cassiaes, 10～30 parts of Folium Camelliae sinensis, through being processed into tablet, granule, pill, capsule or oral liquid.
2. the fat-reducing Chinese medicine of treatment Simple Obesity according to claim 1 is characterized in that also can adding in the described raw material 10～30 parts of Flos Loniceraes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135231 CN1233377C (en) | 2003-06-18 | 2003-06-18 | Fat reducing Chinese drugs for treating simple obesity |
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|---|---|---|---|
| CN 03135231 CN1233377C (en) | 2003-06-18 | 2003-06-18 | Fat reducing Chinese drugs for treating simple obesity |
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| CN1565554A CN1565554A (en) | 2005-01-19 |
| CN1233377C true CN1233377C (en) | 2005-12-28 |
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| CN 03135231 Expired - Fee Related CN1233377C (en) | 2003-06-18 | 2003-06-18 | Fat reducing Chinese drugs for treating simple obesity |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100345566C (en) * | 2005-04-11 | 2007-10-31 | 成都华高药业有限公司 | Medicine composition used for reducing weight, prepn. method and use thereof |
| CN101642165B (en) * | 2009-06-11 | 2012-12-12 | 杭州六易科技有限公司 | Method for preparing weight-reducing yoghurt beverage |
| CN104208488A (en) * | 2014-09-23 | 2014-12-17 | 李成娇 | Medicine combination with antiobesity effects |
| CN105963440A (en) * | 2016-06-29 | 2016-09-28 | 张燕蕾 | Traditional Chinese medicine for treating simple obesity by combining acupuncture and preparation method of traditional Chinese medicine |
| CN113117036A (en) * | 2021-04-15 | 2021-07-16 | 深圳市第三人民医院(深圳市肝病研究所) | A medicine containing green tea extract for treating fatty liver and its preparation method |
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Granted publication date: 20051228 Termination date: 20120618 |