CN1555849A - Intestine moistening oral liquid and its preparation method - Google Patents
Intestine moistening oral liquid and its preparation method Download PDFInfo
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- CN1555849A CN1555849A CNA2004100000737A CN200410000073A CN1555849A CN 1555849 A CN1555849 A CN 1555849A CN A2004100000737 A CNA2004100000737 A CN A2004100000737A CN 200410000073 A CN200410000073 A CN 200410000073A CN 1555849 A CN1555849 A CN 1555849A
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
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- 238000000034 method Methods 0.000 claims description 4
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
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- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine in the form of oral liquid for moistening intestine and treating constipation is prepared from 4 Chinese-medicinal materials including hemp seed, honey mulberry fruit, etc. Its advantages are high curative effect, quickly taking its effect and no toxic by-effect.
Description
Technical field
The present invention relates to a kind of intestine-moisturizing oral liquid, be a kind of main treatment deficiency of YIN and women's blood deficiency and constipation in puerperal be Chinese patent medicine and a kind of preparation method thereof of raw material with the Chinese herbal medicine.
Background technology
Constipation is a kind of commonly encountered diseases and frequently-occurring disease, and patient's defecation frequency is few, lacks just meaning, and class is just discharged difficulty, and defecation time is long, and the excrement piece is too hard.Very easily cause complication such as hemorrhoid, stomachache, anal fissure and sacral nerves pain.Because intestinal food debris, metabolite and toxin can not in time excrete, also can cause slight toxemia again, show as loss of appetite, the bitter taste of feeling sick, lethargy, dizzy weak, diseases such as systemic pain and anemia malnutrition.Current, treatment constipation Western medicine commonly used, these Western medicine not only cost an arm and a leg, and toxic and side effects is also higher, cathartic is all adopted in the constipation of utilization Chinese herbal treatment, and dose is many, effect is strong, easily hinders vigour after taking, and is not suitable for patients such as the old people or the deficiency of YIN and women's blood deficiency and constipation in puerperal.
Summary of the invention
The purpose of this invention is to provide a kind of intestine-moisturizing oral liquid, mainly treat the old people or the deficiency of YIN and women's blood deficiency and constipation in puerperal, have the treatment weakness constipation can moisten do not rush down with instant effect, good effect, have no side effect, advantage that price is low.The method of a kind of convenience, feasible and low-cost this oral liquid of processing is provided simultaneously.
Solution of the present invention is according to the rule of the traditional Chinese medical science to weakness constipation treatment, i.e. the body resistance strengthening and constitution consolidating, the kidney invigorating collateral dredging, eliminating toxic substances to remove stasis, Yin-nourishing and body fluid promoting, loosening bowel to relieve constipation.Tcm theory thinks that weakness constipation's pathogenesis has insufficiency of vital energy and blood, and insufficiency of kidney-QI etc. are divided into the deficiency of vital energy, the cloudy constipation thanks to of blood deficiency.And think " constipation, nephropathy are also ", kidney master five liquid, body fluid is contained, then stool and, constipation also has direct relation with the spleen lung.The present invention forms according to above-mentioned rule, can the kidney invigorating collateral dredging, and eliminating toxic substances to remove stasis again can the body resistance strengthening and constitution consolidating, Yin-nourishing and body fluid promoting, loosening bowel to relieve constipation.Fructus Cannabis of the present invention can intestine moistening, and the body profit can be gone dry, and sharp large intestine is depressed just to be closed, and all old blood is uninteresting, and puerperal, QI and blood had some setbacks, after being ill vigour multiple or report a little less than can not move all and control.Semen Pruni is returned spleen, can moisturize laxation, the kind dry stool retained in large intestine of leading.Fructus Cannabis is a monarch drug, and Semen Pruni is a ministerial drug, and the monarch and his subjects' compatibility is used, and Fructus Cannabis is gone into edema caused by disorder of QI partially, and downhill race circulation of qi promoting, relieving constipation are rushed down down, two medicine compatibilities, and QI and blood is also transferred, and profit is just rushed down down.It is cold that Fructus Mori belongs to acid, GUIXIN, liver, kidney channel, and beneficial blood and heat extraction are the enrich blood medicine of tonifying YIN of removing heat from blood, the present invention is with its tonifying YIN of enriching blood, the nourishing YIN for benefiting the kidney, promoting the production of body fluid to moisturize is adjuvant drug.The Mel invigorating middle warmer is moisturized, and heat-clearing and toxic substances removing nourishes the five internal organs, logical core large intestine, and many medicines that are in harmonious proportion are messenger drug.Fructus Cannabis of the present invention is moisturized, and goes into blood system partially, and edema caused by disorder of QI is gone in the Semen Pruni downhill race partially, the Fructus Mori YIN nourishing of enriching blood, and the Mel invigorating middle warmer, four medicines share, and giving consideration to both the incidental and fundamental is played Yin-nourishing and body fluid promoting altogether, the merit of moistening dryness for relaxing bowels.
The present invention is made by following raw medicaments in portion by weight:
200～300 parts of 150～250 parts of Semen Prunis of Fructus Cannabis
580～780 parts of 25～100 parts of Mel of Fructus Mori
Preferred weight part of each raw material of the present invention is:
230～270 parts of 180～220 parts of Semen Prunis of Fructus Cannabis
610～650 parts of 40～80 parts of Mel of Fructus Mori
Optimum weight part of each raw material of the present invention is:
250 parts of 200 parts of Semen Prunis of Fructus Cannabis
680 parts of 50 parts of Mel of Fructus Mori
The preparation method of a kind of intestine-moisturizing oral liquid of the present invention is: the Fructus Cannabis of getting fire earlier, choose decontamination, and water is clean towards Xian, and oven dry is inserted it in heat pot, and with the method for frying, slow fire is fried to little yellow, takes out; Semen Pruni and Fructus Mori are cleaned roguing, dry; Again Fructus Cannabis and Semen Pruni are ground into granule; Again granular Fructus Cannabis and Semen Pruni and Fructus Mori mixing and water adding were soaked 0.7～1.5 hour, put and decoct with water secondary in the multi-function extractor, add up the water of 8～12 times of amounts of medical material for the first time, decocted 2 hours, get decocting liquid, filter, add up the water of 6～8 times of amounts of medical material for the second time, decocted 1 hour, getting twice decocting liquid merges, filter, relative density is 1.05 concentrated solution when being concentrated into 90 ℃, puts 0～5 ℃ of deepfreeze 24 hours, cold preservation liquid added 0.3% filter aid kieselguhr, filter, filtrate reconcentration extremely every 1ml contains 1g crude drug amount, concentrated filtrate is added Mel boiled 40～50 minutes, add 0.2% potassium sorbate again, add water to 1000ml again, stir, put 0～5 ℃ of deepfreeze 24 hours, cold preservation liquid is filtered, embedding, 105 ℃ of high temperature sterilizes, packing is promptly.
The intestine-moisturizing oral liquid that the present invention makes can be described as " two core intestine-moisturizing oral liquid ", also can be described as " oral liquid is led in intestine moistening ".Glass bottle, every bottle of 10ml, oral, a 10～20ml, a twice-daily.
Clinical drug of the present invention uses the result to show that following advantage is arranged;
1, the Chinese herbal medicine each component selected for use of the present invention meets the pharmaceutical control law regulation, utilizes the comprehensive function treatment weakness constipation of the Chinese medicine of respectively distinguishing the flavor of, and does not have chemical sweeting agent, and is nontoxic to human body.Show that through animal acute toxicity test underproof animal end sees any toxic reaction, its main organs does not have tangible change yet, and mice is 88g crude drug/kg to the maximum tolerated dose of medicinal liquid of the present invention, is 93.2 times of clinical people's consumption, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention can treat and effect a radical cure the weakness constipation effectively, and other constipation is also had better curative effect, has improved patient's life quality and the time greatly, and higher healing rehabilitation efficacy is arranged.And the medical material cost is low, and cost of manufacture is low and simple and practical.
For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the weakness constipation; Treat various weakness constipation patient 300 examples, the age is 26～86 years old, and radical cure recovery from illness accounts for 18%, and produce effects accounts for 57%, effectively accounts for 19%, and is invalid 6%, and effective percentage reaches more than 94%.After treatment in five days, the patient changes all that stool is stiff, and weak perspiration is had a dizzy spell, the symptom of dry pharynx dysphoria with smothery sensation and abdominal distention and pain, and patient do not have any untoward reaction, and three big routine tests and hepatic and renal function detection are no abnormal.And cost is low, and mouthfeel is good, instant effect and taking conveniently.
The specific embodiment
Take by weighing raw material by following weight:
Fructus Cannabis 200g Semen Pruni 250g
Fructus Mori 50g Mel 680g
Production method is as follows: the Fructus Cannabis of getting fire earlier, choose decontamination, and water is clean towards Xian, and oven dry is inserted it in heat pot, and with the method for frying, slow fire is fried to little yellow, takes out; Semen Pruni and Fructus Mori are cleaned roguing, dry; Again Fructus Cannabis and Semen Pruni are ground into granule; Again granular Fructus Cannabis and Semen Pruni and Fructus Mori mixing and water adding were soaked 1 hour, put and decoct with water secondary in the multi-function extractor, add up the water of 10 times of amounts of medical material for the first time, decocted 2 hours, get decocting liquid, filtration.Add up for the second time the water of 7 times of amounts of medical material, decocted 1 hour, get twice decocting liquid and merge, filter, filtrate is inserted in the economic benefits and social benefits vacuum concentrator, and relative density is 1.05 concentrated solution when being concentrated into 90 ℃, puts 0～5 ℃ of deepfreeze 24 hours.Cold preservation liquid is added 0.3% filter aid kieselguhr, filter, filtrate is inserted in the economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml and contains 1g crude drug amount.Concentrated filtrate is added Mel boiled 45 minutes, add the potassium sorbate that accounts for concentrated solution 0.2% again, add water to 1000ml again, stir, put 0～5 ℃ of deepfreeze 24 hours, cold preservation liquid is filtered, in the embedding bottle, 105 ℃ of high temperature sterilizes, packing is promptly.
Claims (4)
1, a kind of intestine-moisturizing oral liquid is characterized in that it is made by following raw medicaments in portion by weight:
200～300 parts of 150～250 parts of Semen Prunis of Fructus Cannabis
580～780 parts of 25～100 parts of Mel of Fructus Mori
2, a kind of intestine-moisturizing oral liquid according to claim 1, wherein the weight portion of each raw material is:
230～270 parts of 180～220 parts of Semen Prunis of Fructus Cannabis
610～650 parts of 40～80 parts of Mel of Fructus Mori
3, a kind of intestine-moisturizing oral liquid according to claim 1, wherein the weight portion of each raw material is:
250 parts of 200 parts of Semen Prunis of Fructus Cannabis
680 parts of 50 parts of Mel of Fructus Mori
4, a kind of preparation method of intestine-moisturizing oral liquid is characterized in that: the Fructus Cannabis of getting fire earlier, choose decontamination, and water is clean towards Xian, and oven dry is inserted it in heat pot, and with the method for frying, slow fire is fried to little yellow, takes out; Semen Pruni and Fructus Mori are cleaned roguing, dry; Again Fructus Cannabis and Semen Pruni are ground into granule; Again granular Fructus Cannabis and Semen Pruni and Fructus Mori mixing and water adding were soaked 0.7～1.5 hour, put and decoct with water secondary in the multi-function extractor, add up the water of 8～12 times of amounts of medical material for the first time, decocted 2 hours, get decocting liquid, filter, add up the water of 6～8 times of amounts of medical material for the second time, decocted 1 hour, getting twice decocting liquid merges, filter, relative density is 1.05 concentrated solution when being concentrated into 90 ℃, puts 0～5 ℃ of deepfreeze 24 hours, cold preservation liquid added 0.3% filter aid kieselguhr, filter, filtrate reconcentration extremely every 1ml contains 1g crude drug amount, concentrated filtrate is added Mel boiled 40～50 minutes, add 0.2% potassium sorbate again, add water to 1000ml again, stir, put 0～5 ℃ of deepfreeze 24 hours, cold preservation liquid is filtered, embedding, 105 ℃ of high temperature sterilizes, packing is promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100000737A CN1244346C (en) | 2004-01-12 | 2004-01-12 | Intestine moistening oral liquid and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100000737A CN1244346C (en) | 2004-01-12 | 2004-01-12 | Intestine moistening oral liquid and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1555849A true CN1555849A (en) | 2004-12-22 |
| CN1244346C CN1244346C (en) | 2006-03-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100000737A Expired - Lifetime CN1244346C (en) | 2004-01-12 | 2004-01-12 | Intestine moistening oral liquid and its preparation method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895396B (en) * | 2006-06-27 | 2010-05-12 | 天津中新药业集团股份有限公司达仁堂制药厂 | Chinese-medicinal preparation with Yin-nourishing, intestin-moistening and bowls-relaxing functions, and preparation method thereof |
| CN102846716A (en) * | 2012-03-20 | 2013-01-02 | 广东药学院 | Traditional Chinese medicine composition for defaecation and preparation method |
| CN102872233A (en) * | 2012-10-17 | 2013-01-16 | 哈药集团中药二厂 | Oral preparation contributed to improving gastrointestinal function |
| CN104474319A (en) * | 2014-11-25 | 2015-04-01 | 沙珍萍 | Bowel cleaning powder used before endoscopic operation in urinary surgery and preparation method thereof |
| CN104491530A (en) * | 2014-12-16 | 2015-04-08 | 济南方宇文化传媒有限公司 | Granule for treating constipation caused by bowel dysfunction and preparation method thereof |
| CN109303209A (en) * | 2018-09-30 | 2019-02-05 | 黄冈师范学院 | A kind of beverage for relief of constipation |
-
2004
- 2004-01-12 CN CNB2004100000737A patent/CN1244346C/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895396B (en) * | 2006-06-27 | 2010-05-12 | 天津中新药业集团股份有限公司达仁堂制药厂 | Chinese-medicinal preparation with Yin-nourishing, intestin-moistening and bowls-relaxing functions, and preparation method thereof |
| CN102846716A (en) * | 2012-03-20 | 2013-01-02 | 广东药学院 | Traditional Chinese medicine composition for defaecation and preparation method |
| CN102872233A (en) * | 2012-10-17 | 2013-01-16 | 哈药集团中药二厂 | Oral preparation contributed to improving gastrointestinal function |
| CN104474319A (en) * | 2014-11-25 | 2015-04-01 | 沙珍萍 | Bowel cleaning powder used before endoscopic operation in urinary surgery and preparation method thereof |
| CN104491530A (en) * | 2014-12-16 | 2015-04-08 | 济南方宇文化传媒有限公司 | Granule for treating constipation caused by bowel dysfunction and preparation method thereof |
| CN109303209A (en) * | 2018-09-30 | 2019-02-05 | 黄冈师范学院 | A kind of beverage for relief of constipation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1244346C (en) | 2006-03-08 |
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