CN1552422A - Motherwort soft capsule and preparing method thereof - Google Patents
Motherwort soft capsule and preparing method thereof Download PDFInfo
- Publication number
- CN1552422A CN1552422A CNA2003101098013A CN200310109801A CN1552422A CN 1552422 A CN1552422 A CN 1552422A CN A2003101098013 A CNA2003101098013 A CN A2003101098013A CN 200310109801 A CN200310109801 A CN 200310109801A CN 1552422 A CN1552422 A CN 1552422A
- Authority
- CN
- China
- Prior art keywords
- soft capsule
- herba leonuri
- gelatin
- titanium dioxide
- silica gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A motherwort softgel is composed of the active component prepared from motherwort extract, silica gel powder, hydrogenated coconut oil, wasp wax and soybean salad oil, and the coated layer prepared from gelatin, glycerine, sorbitol, citric acid, TiO2 and water.
Description
Technical field: the invention belongs to medical technical field, particularly a kind of Herba Leonuri soft capsule and preparation method thereof.
Background technology: at present, be used for the treatment of the accumulation of heat blood stasis clinically, menorrhagia; Puerperal metrorrhagia, the uterus demobilization not Herba Leonuri pharmaceutical preparation of congruent disease mainly contains ext leonuri sibirici liq, oral liquid, tablets and other formulations.But ext leonuri sibirici liq, oral liquid and tablet etc. not only all exist mouthfeel bitter in the mouth, olfactory sensation that the uncomfortable defective such as flavor of smelling is arranged; And the quality of fluid extract and oral liquid is stable inadequately, is easy to generate precipitation, transports, carries inconvenience; Tablet then dissolves in the stomach slowly, the effect of gathering waits problem more slowly.
Summary of the invention: technical problem to be solved by this invention is: for clinically provide that a kind of alternative, medicine is stable, determined curative effect, taking convenience, outward appearance are good, gather and imitate fast Herba Leonuri soft capsule and preparation method thereof.Its technical scheme is:
A kind of Herba Leonuri soft capsule, be made up of soft capsule content and soft capsule material, it is characterized in that: the raw material components of described soft capsule content and percentage by weight thereof are: Herba Leonuri dry extract 15-45, micropowder silica gel 2-5, hydrogenated coconut oil 2-5, yellow beeswax 2-7, soybean salad oil 50-70.
The raw material components of described soft capsule material is: gelatin, glycerol, sorbitol, citric acid, titanium dioxide, water, its proportioning are 1: 0.1-0.3: 0.05-0.15: 0.04-0.08: 0.005-0.015: 1.1-1.3.
Its preparation method is:
1) will be broken into fine powder with Herba Leonuri dry extract and the micropowder silica gel mixed powder that conventional method obtains, and cross 80 mesh sieves and get the extractum mixed powder; After hydrogenated coconut oil, yellow beeswax and soybean salad oil heating in water bath dissolve, stir miscible; Add Herba Leonuri dry extract again and mix the fine powder of pulverizing with micropowder silica gel, stirring and evenly mixing is regulated the colloid mill fineness 10-40min that refluxes under the 1-40um condition, become finely dispersed suspension, promptly gets soft capsule content;
2) get titanium dioxide and a spot of glycerol, water mixed grinding, get the titanium dioxide emulsion; After getting remaining water and glycerol and sorbitol, citric acid, gelatin heating in water bath and dissolve by proportioning, add above-mentioned titanium dioxide emulsion again, heated and stirred is even, under condition of negative pressure, the bubble in the gelatin is taken out, the drainage screen remove impurity in the 50-70C insulation, promptly gets the soft capsule material glue;
3) soft capsule content of above-mentioned preparation and soft capsule material glue are dropped into soft capsule and produce in the filling machine and be pressed into soft gelatin capsule, after the drying, clean, dry, promptly get the Herba Leonuri soft capsule with ethanol.
Its technique effect is: Herba Leonuri soft capsule of the present invention, active chemical is clear and definite, has the effect of clearing away heat and cooling blood, change silt regulating menstruation.Be used for the accumulation of heat blood stasis, menorrhagia; Puerperal metrorrhagia, demobilization not congruent disease in uterus is the new varieties of a determined curative effect, application safety, provides an alternative novel form for clinical.The Herba Leonuri soft capsule that adopts preparation method of the present invention to make, it is accurate to have a content of dispersion, the precision height; Can cover the bitterness of medicine and the uncomfortable flavor of smelling, security seal, taking convenience, outward appearance is good; Medicine is stable, and it is fast to dissolve in the stomach, and good bioavailability is arranged, and gathers and imitates advantages such as fast.
The specific embodiment:
Embodiment 1.The Herba Leonuri dry extract 15Kg and the 2Kg micropowder silica gel mixed powder that make with conventional method are broken into fine powder, cross 80 mesh sieves and get the extractum mixed powder; After 2Kg hydrogenated coconut oil, 2Kg yellow beeswax and 50Kg soybean salad oil 60C heating in water bath dissolve, stir miscible; Add Herba Leonuri dry extract again and mix the fine powder of pulverizing with micropowder silica gel, stirring and evenly mixing is regulated the colloid mill fineness 10-40min that refluxes under the 1-40um condition, become finely dispersed suspension, soft capsule content.Get the glycerol of 8Kg titanium dioxide and 30Kg, the water mixed grinding of 20Kg, get the titanium dioxide emulsion; By proportioning get the water 860Kg of surplus and glycerol 130Kg and 80Kg sorbitol, 48Kg citric acid, the 800Kg gelatin dissolves in 85 C heating in water bath, add above-mentioned titanium dioxide emulsion again, heated and stirred is even, under-0.05--0.15Mpa condition, the bubble in the gelatin is taken out, cross 80 mesh filter screen remove impurity, in the 50-70C insulation, get the soft capsule material glue; The soft capsule content of above-mentioned preparation and soft capsule material glue are dropped into soft capsule produce in the filling machine and be pressed into soft gelatin capsule, after dry 24 hours, clean, dry, promptly get the Herba Leonuri soft capsule with ethanol.This capsule is tan soft capsule, and content is the strong thick liquid of brown yellow oil that contains suspended solid extractum, feeble QI, little hardship.
Embodiment 2.The Herba Leonuri dry extract 30Kg and the 3.5Kg micropowder silica gel mixed powder that make with conventional method are broken into fine powder, cross 80 mesh sieves and get the extractum mixed powder; 3.5Kg after hydrogenated coconut oil, 5Kg yellow beeswax and 60Kg soybean salad oil 60C heating in water bath dissolve, stir miscible; Add Herba Leonuri dry extract again and mix the fine powder of pulverizing with micropowder silica gel, stirring and evenly mixing is regulated the colloid mill fineness 10-40min that refluxes under the 1-40um condition, become finely dispersed suspension, soft capsule content.Get the glycerol of 10Kg titanium dioxide and 40Kg, the water mixed grinding of 30Kg, get the titanium dioxide emulsion; By proportioning get the water 1070Kg of surplus and glycerol 160Kg and 100Kg sorbitol, 60Kg citric acid, the 1000Kg gelatin dissolves in the 85C heating in water bath, add above-mentioned titanium dioxide emulsion again, heated and stirred is even, under-0.05--0.15Mpa condition, the bubble in the gelatin is taken out, cross 80 mesh filter screen remove impurity, in the 50-70C insulation, get the soft capsule material glue; The soft capsule content of above-mentioned preparation and soft capsule material glue are dropped into soft capsule produce in the filling machine and be pressed into soft gelatin capsule, after dry 24 hours, clean, dry, promptly get the Herba Leonuri soft capsule with ethanol.This capsule is tan soft capsule, and content is the strong thick liquid of brown yellow oil that contains suspended solid extractum, feeble QI, little hardship.
Embodiment 3.The Herba Leonuri dry extract 45Kg and the 5Kg micropowder silica gel mixed powder that make with conventional method are broken into fine powder, cross 80 mesh sieves and get the extractum mixed powder; After 5Kg hydrogenated coconut oil, 7Kg yellow beeswax and 70Kg soybean salad oil 60C heating in water bath dissolve, stir miscible; Add Herba Leonuri dry extract again and mix the fine powder of pulverizing with micropowder silica gel, stirring and evenly mixing is regulated the colloid mill fineness 10-40min that refluxes under the 1-40um condition, become finely dispersed suspension, soft capsule content.Get the glycerol of 12Kg titanium dioxide and 45Kg, the water mixed grinding of 40Kg, get the titanium dioxide emulsion; By proportioning get the water 1260Kg of surplus and glycerol 195Kg and 120Kg sorbitol, 72Kg citric acid, the 1200Kg gelatin dissolves in the 85C heating in water bath, add above-mentioned titanium dioxide emulsion again, heated and stirred is even, under-0.05--0.15Mpa condition, the bubble in the gelatin is taken out, cross 80 mesh filter screen remove impurity, in the 50-70C insulation, get the soft capsule material glue; The soft capsule content of above-mentioned preparation and soft capsule material glue are dropped into soft capsule produce in the filling machine and be pressed into soft gelatin capsule, after dry 24 hours, clean, dry, promptly get the Herba Leonuri soft capsule with ethanol.This capsule is tan soft capsule, and content is the strong thick liquid of brown yellow oil that contains suspended solid extractum, feeble QI, little hardship.
Claims (3)
1, a kind of Herba Leonuri soft capsule, be made up of soft capsule content and soft capsule material, it is characterized in that: the raw material components of described soft capsule content and percentage by weight thereof are: Herba Leonuri dry extract 15-45, micropowder silica gel 2-5, hydrogenated coconut oil 2-5, yellow beeswax 2-7, soybean salad oil 50-70.
2, a kind of Herba Leonuri soft capsule according to claim 1, it is characterized in that: the raw material components of described soft capsule material is: gelatin, glycerol, sorbitol, citric acid, titanium dioxide, water, its proportioning are 1: 0.1-0.3: 0.05-0.15: 0.04-0.08: 0.005-0.015: 1.1-1.3.
3, a kind of Herba Leonuri preparation of soft capsule method according to claim 1 is characterized in that:
1) will be broken into fine powder with Herba Leonuri dry extract and the micropowder silica gel mixed powder that conventional method obtains, and cross 80 mesh sieves and get the extractum mixed powder; After hydrogenated coconut oil, yellow beeswax and soybean salad oil heating in water bath dissolve, stir miscible; Add Herba Leonuri dry extract again and mix the fine powder of pulverizing with micropowder silica gel, stirring and evenly mixing is regulated the colloid mill fineness 10-40min that refluxes under the 1-40um condition, become finely dispersed suspension, promptly gets soft capsule content;
2) get titanium dioxide and a spot of glycerol, water mixed grinding, get the titanium dioxide emulsion; By proportioning get remaining water and glycerol and sorbitol, citric acid, the gelatin heating in water bath dissolves, and adds above-mentioned titanium dioxide emulsion again, heated and stirred is even, under condition of negative pressure, the bubble in the gelatin is taken out, the drainage screen remove impurity in the 50-70C insulation, promptly gets the soft capsule material glue;
3) soft capsule content of above-mentioned preparation and soft capsule material glue are dropped into soft capsule and produce in the filling machine and be pressed into soft gelatin capsule, after the drying, clean, dry, promptly get the Herba Leonuri soft capsule with ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101098013A CN1552422A (en) | 2003-12-18 | 2003-12-18 | Motherwort soft capsule and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101098013A CN1552422A (en) | 2003-12-18 | 2003-12-18 | Motherwort soft capsule and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1552422A true CN1552422A (en) | 2004-12-08 |
Family
ID=34335392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101098013A Pending CN1552422A (en) | 2003-12-18 | 2003-12-18 | Motherwort soft capsule and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1552422A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101243880B (en) * | 2008-03-26 | 2011-08-17 | 冯新泉 | Rose vinegar soft capsule |
| CN101708173B (en) * | 2009-12-03 | 2012-11-07 | 北京天佑国康科技有限公司 | Soft capsule and application thereof |
| CN104351753A (en) * | 2014-09-17 | 2015-02-18 | 姚大军 | Food for treating dysmenorrheal, cyst of uterus and hysteromyoma |
| CN107440124A (en) * | 2017-10-11 | 2017-12-08 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material |
| CN107485026A (en) * | 2017-10-11 | 2017-12-19 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the enhancing memory soft capsule preparation of capsule material |
| CN107495375A (en) * | 2017-10-11 | 2017-12-22 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the preventing and treating cardiovascular and cerebrovascular disease soft capsule preparation of capsule material |
| CN115721627A (en) * | 2022-11-10 | 2023-03-03 | 南通华山药业有限公司 | Motherwort soft capsule and preparation method thereof |
-
2003
- 2003-12-18 CN CNA2003101098013A patent/CN1552422A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101243880B (en) * | 2008-03-26 | 2011-08-17 | 冯新泉 | Rose vinegar soft capsule |
| CN101708173B (en) * | 2009-12-03 | 2012-11-07 | 北京天佑国康科技有限公司 | Soft capsule and application thereof |
| CN104351753A (en) * | 2014-09-17 | 2015-02-18 | 姚大军 | Food for treating dysmenorrheal, cyst of uterus and hysteromyoma |
| CN107440124A (en) * | 2017-10-11 | 2017-12-08 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material |
| CN107485026A (en) * | 2017-10-11 | 2017-12-19 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the enhancing memory soft capsule preparation of capsule material |
| CN107495375A (en) * | 2017-10-11 | 2017-12-22 | 威海海日水产食品有限公司 | A kind of algin is the preparation method of the preventing and treating cardiovascular and cerebrovascular disease soft capsule preparation of capsule material |
| CN115721627A (en) * | 2022-11-10 | 2023-03-03 | 南通华山药业有限公司 | Motherwort soft capsule and preparation method thereof |
| CN115721627B (en) * | 2022-11-10 | 2024-08-30 | 南通华山药业有限公司 | A herba Leonuri soft capsule and its preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100515397C (en) | Agastachel patchouli qi-righting fast dispersion solid preparation and its preparation method | |
| WO2007041940A1 (en) | Chinese medicinal compositions useful as anti-fatigue, anti-aging and gonadotrophic agent and processes for preparation thereof | |
| CN102309716A (en) | Traditional Chinese medicine composition for treating morbid leucorrhea and preparation method thereof | |
| CN104352594A (en) | Jiangzhining dispersible tablets and preparation method thereof | |
| CN111494507B (en) | Preparation method of internal heat clearing tablets | |
| CN105106347A (en) | Semen ziziphi spinosae soft capsules and preparation method thereof | |
| CN1552422A (en) | Motherwort soft capsule and preparing method thereof | |
| CN102204940B (en) | Evening primrose oil microcapsule and pulverization method | |
| CN108785412B (en) | Composition with function of improving sleep and preparation method thereof | |
| CN102085344B (en) | Aplotaxis carminative sustained-release preparation and preparation method thereof | |
| CN102178658B (en) | Lappaconitine hydrobromide orally disintegrating tablets and preparation method thereof | |
| CN100400033C (en) | Stomach nourishing chewing tablet with aucklandia root and amomum fruit and its preparation process | |
| CN102048841A (en) | Lactogenic traditional Chinese medicine composition and preparation method thereof | |
| CN1327833C (en) | Hawthorn leave flavone capsules and their preparing method | |
| JP2004059503A (en) | Chinese medicine-based jellylike pharmaceutical composition | |
| CN103142888B (en) | Children Qixing drink tea soft capsule preparation | |
| CN102188495B (en) | Preparation method of Chilian oral liquid | |
| CN101708173A (en) | Soft capsule and application thereof | |
| CN100542517C (en) | Calculus bovis detoxifying dropping pill and preparation method thereof | |
| CN101190282B (en) | Sugar-free compound traditional Chinese medicinal preparation for treating upper respiratory tract infection and quality control method thereof | |
| CN100500138C (en) | Xiaoaiping preparation against cancers and its making method | |
| CN100502903C (en) | Anshenning dripping pill for treating neurosism and its preparing method | |
| CN1919214B (en) | Monascus soft capsule and its preparation method | |
| CN100363018C (en) | Honeysuckle flower soft capsule and preparation method thereof | |
| CN102120004A (en) | Method for preparing heart calming and mind tranquilizing preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |