CN1552402A - Clearing lung and stopping Asthma medicine and preparing process thereof - Google Patents
Clearing lung and stopping Asthma medicine and preparing process thereof Download PDFInfo
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Abstract
A Chinese medicine for treating cough and asthma is prepared from 4 Chinese-medicinal materials including scutellaria root, platycodon root, phabitis seed, etc. Its advantages are high curative effect, no toxic by-effect and low cost.
Description
Affiliated technical field:
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of lung heat clearing Dingchuan Chinese medicine and preparation technology thereof.
Background technology:
Bronchial asthma belongs to traditional Chinese medical science asthma category, it is a kind of common, multiple diseases in respiratory system, have repeatedly and show effect, delay difficult characteristics of incidence of healing, be a kind of main chronic disease of serious threat public health in the world wide, still among rising year by year, nearly 100,000,000 people in the whole world suffer from this disease to its M ﹠ M, various countries' prevalence is 1%～13% not wait, the prevalence of China is 1%～4%, and the prevalence of developed countries such as English, U.S., New Zealand is higher relatively, and on the rise; Participate in " ISSAC " international asthma associating epidemiological investigation in China five big cities, also finds that teenager asthma is the trend of obvious rising (near 5%).Not long ago, national sanitary institute and World Health Organization have convened 23 experts of 17 countries, have drafted " global strategy of asthma control ", and the control of visible bronchial asthma has become global problem.
Chinese medicine asthma has experience in several thousand, but in the present commercially available Chinese medicine preparation, still has at alleviation person, and do not have at stage of attack person.
Summary of the invention:
The present invention will overcome existing Chinese medicine and be suitable for the catabasis, and can not be at the deficiency of stage of attack.
For overcoming the shortcoming of prior art, technical scheme of the present invention is:
A kind of lung heat clearing Dingchuan Chinese medicine comprises following component in parts by weight:
1 part-60 parts of 1 part of-30 parts of Radix Platycodoniss of 1 part of-30 parts of Semen Lepidii (Semen Descurainiae) of Radix Scutellariae
1 part-20 parts of Semen Pharbitidiss
The optimum ratio of above-mentioned Chinese medicine preparation is:
30 parts-50 parts of 10 parts of-20 parts of Radix Platycodoniss of 5 parts of-20 parts of Semen Lepidii (Semen Descurainiae)s of Radix Scutellariae
5 parts-15 parts of Semen Pharbitidiss
Above-mentioned Chinese medicine preparation also comprises following component in parts by weight:
1 part-30 parts of Pericarpium Citri Reticulataes
Above-mentioned optimum ratio is: 10 parts-20 parts of Pericarpium Citri Reticulataes
Above-mentioned Chinese medicine preparation also can comprise following component in parts by weight: 1 part-20 parts of Radix Panacis Quinquefoliis
Above-mentioned optimum ratio is: 8 parts-15 parts of Radix Panacis Quinquefoliis
The preferred version of above-mentioned Chinese medicine preparation is:
Radix Scutellariae 15g Semen Lepidii (Semen Descurainiae) 20g Radix Platycodonis 45g
Semen Pharbitidis 18g Pericarpium Citri Reticulatae 15g Radix Panacis Quinquefolii 10g
A kind of preparation technology of above-mentioned lung heat clearing Dingchuan Chinese medicine, it comprises following feedstock production step: A, the Radix Scutellariae coarse powder is decocted with water three times, filters, and merging filtrate is transferred pH value, and insulation is left standstill, and filters, and precipitation washes with water to nearly neutrality, and cold drying is ground into fine powder; B, Pericarpium Citri Reticulatae extract volatile oil, and medicinal residues and Semen Lepidii (Semen Descurainiae), Semen Pharbitidis, Radix Panacis Quinquefolii alcohol reflux three times filter, and merging filtrate is concentrated into finite concentration; C, Radix Platycodonis decoct with water three times, filter, and merging filtrate concentrates, and it is an amount of to add ethanol, leaves standstill, and the leaching supernatant is concentrated into finite concentration.
Above-mentioned technology comprises that also with feedstock production be the liquid preparation step: get Radix Scutellariae extract fine powder and above-mentioned two kinds of solution dosings.
Above-mentioned technology comprises that also with feedstock production be the solid preparation step, with above-mentioned two kinds of solution dryings, is ground into fine powder and Radix Scutellariae extract fine powder and adds an amount of mix homogeneously of excipient jointly.
Above-mentioned preparation is a said dosage form on any pharmaceutics.
Described capsular preparation technology is, it is an amount of to add excipient in the mixture of three kinds of fine powders, add wetting agent then and granulate, and oven drying at low temperature, granulate, spray adds volatile oil, incapsulates, promptly.
Compared with prior art, advantage of the present invention is:
1, relieving asthma, antitussive action is obvious, evident in efficacy: as obviously to prolong its incubation period (P＜0.01) to the caused Cavia porcellus of histamine+acetylcholine (Ach) " asthma ", especially heavy dose of group, be 2.5 times of matched group its incubation period, can significantly expand the guinea pig bronchial smooth muscle that exsomatizes, increase the perfusion flow of lung, resist Ach and antfhistamine contraction (P＜0.01) significantly.In the cough-relieving experiment, each dosage group of the present invention all can prolong cough latent period (P＜0.01) by highly significant.
2, cost is low: prescription medicine raw material resources of the present invention are abundant, and are simple for process, therefore reduced cost, for the patient takes the condition created for a long time;
3, have no side effect: the present invention carries out the toxicity test result and shows, does not see overt toxicity and side effect, does not measure median lethal dose(LD 50), thereby takes no toxicity for a long time;
4, taking convenience, good mouthfeel: preparation of the present invention is reasonable, good mouthfeel, the patient is easy to accept;
5, indication is extensive: not only eliminate the phlegm and antiinflammatory action, and can obviously strengthen the non-specific and specific immune function of mice.
The specific embodiment:
To do detailed argumentation to the present invention with specific embodiment below.
Lung heat clearing of the present invention is purged heat, resolving phlegm and relieving asthma.Be used for bronchial asthma thermal resistance lung card, disease sees that cough with asthma is uncomfortable in chest, gurgling with sputum, and the yellow stiff of expectorant, it is unfavorable to bring up, the fever of the body sweating, thirst and liking drink, it is red etc. that constipation is urinated.
Embodiment 1:
Radix Scutellariae 2g Semen Lepidii (Semen Descurainiae) 20g Radix Platycodonis 5g Semen Pharbitidis 20g
Embodiment 2:
Radix Scutellariae 10g Semen Lepidii (Semen Descurainiae) 20g Radix Platycodonis 50g Semen Pharbitidis 15g
The preparation technology of said embodiment 1 and embodiment 2 is:
It may further comprise the steps:
(1) feedstock production: A, the Radix Scutellariae coarse powder is decocted with water three times, filter, merging filtrate is transferred pH value, and insulation is left standstill, and filters, and precipitation washes with water to nearly neutrality, and cold drying is ground into fine powder; B, Semen Lepidii (Semen Descurainiae), Semen Pharbitidis alcohol reflux three times filter, and merging filtrate is concentrated into to finite concentration; C, Radix Platycodonis decoct with water three times, filter, and merging filtrate concentrates, and it is an amount of to add ethanol, leaves standstill, and the leaching supernatant is concentrated into finite concentration.
(2) be liquid preparation with feedstock production, get Radix Scutellariae extract fine powder and above-mentioned two kinds of solution dosings.
In embodiment 1 and embodiment 2, Radix Scutellariae wherein, bitter in the mouth, cold in nature, return warps such as lung, large intestine, the kind lung heat clearing of merit is purged heat, the kind lung-heat cough with asthma of controlling, as " the southern regions of the Yunnan Province book on Chinese herbal medicine " say its can " up purte the white ... so-called excess-fire can be rushed down, and Radix Scutellariae is also ".Zhang Jiegu then say its can " profit is gas in the heart; expectorant on the diaphragm that disappears ", " not Lu " carry that it can " treat expectorant heat ", " detailed outline " calls that it can control " cough caused by pathogenic fire ", " book on Chinese herbal medicine just " says its " fire of the clear part of the body cavity above the diaphragm housing the heart and lungs; expectorant promoting the circulation of QI; relieving asthma and cough ", illustrates that Radix Scutellariae not only has the merit of the eliminating the pathogens from the lung heat clearly, but also tool expectorant heat, sharp breast gas, the effect of relieving asthma and cough says promptly that as " danxi's experiential therapy " it can " purte the white, heat-phlegm on the diaphragm that disappears ".Radix Scutellariae is promptly brought into play lung heat clearing and is purged heat in we, the merit of resolving phlegm and relieving asthma is crucial and establish at the pathogenesis of bronchial wheezing accumulation of phlegm-heat in the lung card, so with being monarch drug.
Radix Platycodonis, bitter in the mouth, suffering have lung qi dispersing, eliminate the phlegm, sore-throat relieving, the effect of evacuation of pus says that as " book on Chinese herbal medicine converge with speech " it is " a main sharp lung qi; logical throat; alleviating distention in middle-JIAO is regulated the flow of vital energy, and the key medicine of the capable expectorant of dissipating depression of QI also ", " property of medicine opinion " also calls it can " ... removing food stagnancy is poly-, sputum; main lung-heat tachypnea is coughed contrary ", amplification on Canon of Materia Medica carry its can " control lung-heat gas run quickly short cough contrary ".In we, Radix Platycodonis both can have been delivered and loose evilly, and a surname sends out a lung qi, again can the sharp diaphragm of wide born of the same parents, and the capable expectorant of dissipating depression of QI, sore-throat relieving is coughed surely, strengthens the merit of monarch drug lung qi dispersing expectorant promoting the circulation of QI, with being ministerial drug; Semen Lepidii (Semen Descurainiae), cold in nature, " Kaibao Bencao " put down in writing and said in its energy " treat gas cough on the lung abscess, Dingchuan is urged; remove phlegm retention in the heart ", " the koan dark purple pearl warp " that it can " decide the dyspnea with rapid and short breath of lung qi; treat the syncope due to accumulation of phlegm of long-pending drink ", " property of medicine opinion " says its " the energy diuresis is taken out the urgency of panting on the lung qi, antitussive ", as seen it has the eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma purges heat by the merit of heresy, and the kind sputum of controlling is stopped up lung, impairment of purifying and descending function of the lung and dyspnea due to adverse flow of lung-QI breath, must not put down for sleeping in, cough with copious phlegm, wheezing card such as pant, Semen Lepidii (Semen Descurainiae) eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma power wins, in the side to strengthen monarch drug eliminating the pathogens from the lung heat clearing away, the power of eliminating phlegm and relieving asthma.Semen Lepidii (Semen Descurainiae) and Radix Platycodonis one rise and one drop are opposed each other and yet also complement each other, and are total to the principal drug assistance harmonizing the functional activities of vital QI, and lung a surname is fallen often to be had, and breathes in order, and hot clearing away phlegm is dispelled, and stridulating stops.The two is ministerial drug altogether in the side.Semen Pharbitidis, diarrhea falls in hardship, can eliminate the phlegm by drink, phlegm retention goes then lung qi to be declared to fall, cough with asthma can be put down, and at the Fang Zhongzuo Semen Lepidii (Semen Descurainiae), helps its eliminating the pathogens from the lung of reducing phlegm, the merit of relieving cough and asthma, Semen Pharbitidis can also the diuretic relieving constipation, eliminates the phlegm by drink, and the kind expectorant of controlling is stopped up and breathed with cough, cards such as constipation have the large intestine of rushing down again to control the wonderful of lung, in order to adjuvant drug in the side.More than four flavor compatibilities the lung heat clearing away is rushed down, expectorantization is breathed heavily flat, so be used for bronchial asthma accumulation of phlegm-heat in the lung card, disease sees that cough with asthma is uncomfortable in chest, gurgling with sputum, expectorant Huang stiff, expectoration is unfavorable, the fever of the body sweating, thirst and liking drink, it is red etc. that constipation is urinated.
Embodiment 3:
Radix Scutellariae 10g Semen Lepidii (Semen Descurainiae) 20g Radix Platycodonis 50g Semen Pharbitidis 15g
Pericarpium Citri Reticulatae 10g
Pericarpium Citri Reticulatae in addition in this programme, because of it can return spleen, stomach, lung meridian, " pearl sac " say that it can " sharp lung qi ", and " Bencao Congxin " calls it can " dampness expectorant ", " the medical center bun medicine property of medicine " says its energy " eliminating the pathogens from the lung gas; lowering the adverse flow of QI ", " main in pleasant, expectorant is gone strongly fragrant ", " property of medicine opinion " also says that it can " control gas between chest and diaphragm; appetizing; main diarrhea due to disorder of qi, expectorant saliva be controlled gas and coughed ", cooperate Semen Lepidii (Semen Descurainiae) in the prescription, to strengthen eliminating phlegm and removing dampness, the chest stuffiness relieving removes the effect of painful abdominal mass, and the heap soil or fertilizer over and around the roots that visible Pericarpium Citri Reticulatae both can have been managed lung qi stagnates, be longer than in the accent again and whet the appetite, short transporting and transforming function of the spleen and stomach, drying dampness to eliminate phlegm blocks at the lung qi that accumulation of phlegm-heat in the lung occurred in the side, cough with copious phlegm etc. and establishing, and Pericarpium Citri Reticulatae is warm in nature, but in the side the cold and cool property of using corrigent monarch-minister drug, so the effect used is more in the side.
The preparation technology of said embodiment 3 is:
It may further comprise the steps:
(1) feedstock production: A, the Radix Scutellariae coarse powder is decocted with water three times, filter, merging filtrate is transferred pH value, and insulation is left standstill, and filters, and precipitation washes with water to nearly neutrality, and cold drying is ground into fine powder; B, Pericarpium Citri Reticulatae extract volatile oil, and volatile oil and medicinal liquid device are in addition preserved, and medicinal residues and Semen Lepidii (Semen Descurainiae), Semen Pharbitidis alcohol reflux three times filter, and merging filtrate is concentrated into finite concentration; C, Radix Platycodonis decoct with water three times, filter, and merging filtrate concentrates, and it is an amount of to add ethanol, leaves standstill, and the leaching supernatant is evaporated to finite concentration.
(2) be solid preparation with feedstock production:, be ground into fine powder and Radix Scutellariae extract fine powder and add an amount of mix homogeneously of excipient jointly with two kinds of solution dryings in the step ().
Embodiment 4:
Radix Scutellariae 10g Semen Lepidii (Semen Descurainiae) 20g Radix Platycodonis 50g Semen Pharbitidis 15g
Pericarpium Citri Reticulatae 5g Radix Panacis Quinquefolii 15g
Embodiment 5:
Radix Scutellariae 15g Semen Lepidii (Semen Descurainiae) 20g Radix Platycodonis 45g Semen Pharbitidis 18g
Pericarpium Citri Reticulatae 15g Radix Panacis Quinquefolii 10g
The preparation technology of the Chinese patent medicine among said embodiment 4 and the embodiment 5 may further comprise the steps:
(1) feedstock production,
A: the Radix Scutellariae coarse powder is decocted with water three times, filter, merging filtrate is transferred pH value, and insulation is left standstill, and filters, and precipitation washes with water to nearly neutrality, and cold drying is ground into fine powder;
B: Pericarpium Citri Reticulatae extracts volatile oil, and volatile oil and medicinal liquid device are in addition preserved, and medicinal residues and Semen Lepidii (Semen Descurainiae), Semen Pharbitidis, Radix Panacis Quinquefolii alcohol reflux three times filter, and merging filtrate is concentrated into finite concentration;
C: Radix Platycodonis decocts with water three times, filters, and merging filtrate concentrates, and it is an amount of to add ethanol, leaves standstill, and the leaching supernatant is evaporated to finite concentration.
(2) preparation of solid preparation: with B step in () and the concentrated solution in the C step, drying is ground into fine powder, the Radix Scutellariae extract fine powder mix homogeneously that A step among this fine powder and () is obtained;
(3) described capsular preparation technology is, and is an amount of with adding starch in the fine powder mixture that obtains in the step (two), adds alcohol granulation then, oven drying at low temperature, and granulate, spray adds volatile oil, incapsulates, promptly.
Radix Panacis Quinquefolii in addition in this programme, because of its bitter but slightly sweet taste, cold in nature, both kind boosting qi and nourishing yin, asthenic fire clearly again, born fluid, at the asthma accumulation of phlegm-heat in the lung with the passing of time, the anxiety in consumption impairing the lung Tianjin is arranged and establish, probably it consumes lung qi again, and cough expectorant blood appears in the cloudy hyperactivity of fire that loses of the deficiency of vital energy, diseases such as dryness of the mouth and throat, so use with " relieving restlessness is tired for tonifying the lung pathogenic fire reducing, born fluid ", and can prevent asthma with the passing of time, trauma healthy energy prevents trouble before it happens, and the meaning of " preventive treatment of disease " is arranged, not only can make our curative effect better, and can prevent that with the passing of time asthma from damaging the anxiety of healthy energy.This moment, the Six-element compatibility can make clinical efficacy improve, and was effective good recipe of treatment bronchial asthma accumulation of phlegm-heat in the lung card.
Among embodiment 4 and the embodiment 5, embodiment 5 is most preferred embodiments.
Animal acute toxicity test:
Give not lethal dose (Dn) of minimum full lethal dose (Dm) that the administration of ICR strain white mice coloclysis, result fail to measure this product and maximum, test so carry out the mice maximum dosage-feeding of this medicine.Use Cmax of this product and the maximum administration capacity of mice, through a gastric infusion, the lung heat clearing Dingchuan capsule for asthma mice maximum dosage-feeding that records is 30g/kg/ time, amount to crude drug 148.2g/kg/ time, be equivalent to clinical people with weighing machine and intend 444.4 times of consumption, animal does not have the overt toxicity reaction under this dosage.
According to situations such as lung heat clearing Dingchuan capsule for asthma prescription composition and clinical course of treatment, the long term toxicity test of two kinds of sexes, three 3 months dosage cycles coloclysis administration has been carried out in this experiment to SD strain rat, maximal dose is 12.0g/kg/ day (amounting to crude drug 59.3g/kg/ day), is equivalent to clinical people approximately and intends 177.8 times of consumption every day.Day by day observe the general situation of animal after the administration, weigh weekly 1 time, and adjust the administration capacity by body weight.In administration after 3 months every group put to death 2/3 animal, in addition 1/3 animal is cooked the convalescent period test in two weeks of drug withdrawal.Result of the test, after administration 3 months and two convalescent periods in week, the lung heat clearing Dingchuan capsule for asthma does not all have obviously influence, the yet no abnormal change of system's dissection, organ coefficient and histopathological examination to the general situation of animal, hematology, blood biochemical and electrocardiogram etc.So in the long term toxicity test of rat coloclysis administration in 3 months, do not find overt toxicity reaction and retardance toxic reaction.Above-mentioned experimental result shows: the lung heat clearing Dingchuan capsule for asthma is in 3 months long term toxicity test of rat coloclysis administration, do not cause tangible toxic reaction and retardance toxic reaction, providing the nontoxic amounts of reactants of animal with weighing machine is 12.0g/kg/ day, amount to crude drug in whole 59.3g/kg/ day, be equivalent to clinical people approximately and intend 177.8 times of consumption.
Claims (10)
1, a kind of lung heat clearing Dingchuan Chinese medicine is characterized in that: comprise following component in parts by weight, 1 part-20 parts of 1 part of-60 parts of Semen Pharbitidiss of 1 part of-30 parts of Radix Platycodonis of 1 part of-30 parts of Semen Lepidii (Semen Descurainiae) of Radix Scutellariae.
2, a kind of lung heat clearing Dingchuan Chinese medicine as claimed in claim 1 is characterized in that: comprise following component in parts by weight, 5 parts-15 parts of 30 parts of-50 parts of Semen Pharbitidiss of 10 parts of-20 parts of Radix Platycodoniss of 5 parts of-20 parts of Semen Lepidii (Semen Descurainiae)s of Radix Scutellariae.
3, a kind of lung heat clearing Dingchuan Chinese medicine as claimed in claim 1 or 2 is characterized in that: also comprise following component in parts by weight, 1 part-30 parts of Pericarpium Citri Reticulataes.
4, a kind of lung heat clearing Dingchuan Chinese medicine as claimed in claim 1 or 2 is characterized in that: also comprise following component in parts by weight, 10 parts-20 parts of Pericarpium Citri Reticulataes.
5, a kind of lung heat clearing Dingchuan Chinese medicine as claimed in claim 4 is characterized in that: also comprise following component in parts by weight, 1 part-20 parts of Radix Panacis Quinquefoliis.
6, a kind of lung heat clearing Dingchuan Chinese medicine as claimed in claim 4 is characterized in that: also comprise following component in parts by weight, 8 parts-15 parts of Radix Panacis Quinquefoliis.
7, a kind of lung heat clearing Dingchuan Chinese medicine as claimed in claim 6 is characterized in that: described Chinese medicine preparation is,
45 parts of 20 parts of Radix Platycodoniss of 15 parts of Semen Lepidii (Semen Descurainiae)s of Radix Scutellariae
10 parts of 15 parts of Radix Panacis Quinquefoliis of 18 parts of Pericarpium Citri Reticulataes of Semen Pharbitidis.
8, the preparation technology of a kind of above-mentioned lung heat clearing Dingchuan Chinese medicine as claimed in claim 1, it is characterized in that: it comprises following feedstock production step: A, the Radix Scutellariae coarse powder is decocted with water three times, filter, merging filtrate is transferred pH value, insulation, leave standstill, filter, precipitation washes with water to nearly neutrality, cold drying is ground into fine powder; B, Pericarpium Citri Reticulatae extract volatile oil, and medicinal residues and Semen Lepidii (Semen Descurainiae), Semen Pharbitidis, Radix Panacis Quinquefolii alcohol reflux three times filter, and merging filtrate is concentrated into finite concentration; C, Radix Platycodonis decoct with water three times, filter, and merging filtrate concentrates, and it is an amount of to add ethanol, leaves standstill, and the leaching supernatant is concentrated into finite concentration.
9, the preparation technology of a kind of above-mentioned lung heat clearing Dingchuan Chinese medicine as claimed in claim 8 is characterized in that: described technology comprises that also with feedstock production be the liquid preparation step, promptly gets Radix Scutellariae extract fine powder and above-mentioned two kinds of solution dosings.
10, the preparation technology of a kind of above-mentioned lung heat clearing Dingchuan Chinese medicine as claimed in claim 8, it is characterized in that: described technology comprises that also with feedstock production be the solid preparation step, be about to above-mentioned two kinds of solution dryings, be ground into fine powder and Radix Scutellariae extract fine powder and add an amount of mix homogeneously of excipient jointly.
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| CN 03134246 CN1255123C (en) | 2003-06-04 | 2003-06-04 | Clearing lung and stopping Asthma medicine and preparing process thereof |
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| CN 03134246 CN1255123C (en) | 2003-06-04 | 2003-06-04 | Clearing lung and stopping Asthma medicine and preparing process thereof |
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| CN1255123C CN1255123C (en) | 2006-05-10 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990025A (en) * | 2014-06-17 | 2014-08-20 | 刘青振 | Traditional Chinese medicine for treating children cough variant asthma and preparation method of traditional Chinese medicine |
| CN105267307A (en) * | 2015-11-12 | 2016-01-27 | 常州大学 | Preparation method of traditional Chinese medicine instant granule for treating bronchial asthma |
| CN105920310A (en) * | 2016-05-01 | 2016-09-07 | 镇江荣邦生物科技有限公司 | Preparation method of asthma-relieving aerosol |
-
2003
- 2003-06-04 CN CN 03134246 patent/CN1255123C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990025A (en) * | 2014-06-17 | 2014-08-20 | 刘青振 | Traditional Chinese medicine for treating children cough variant asthma and preparation method of traditional Chinese medicine |
| CN105267307A (en) * | 2015-11-12 | 2016-01-27 | 常州大学 | Preparation method of traditional Chinese medicine instant granule for treating bronchial asthma |
| CN105920310A (en) * | 2016-05-01 | 2016-09-07 | 镇江荣邦生物科技有限公司 | Preparation method of asthma-relieving aerosol |
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| Publication number | Publication date |
|---|---|
| CN1255123C (en) | 2006-05-10 |
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