CN1551885A - 环状吲哚和杂吲哚衍生物、其作为药物的制备和用途 - Google Patents
环状吲哚和杂吲哚衍生物、其作为药物的制备和用途 Download PDFInfo
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- CN1551885A CN1551885A CNA028172639A CN02817263A CN1551885A CN 1551885 A CN1551885 A CN 1551885A CN A028172639 A CNA028172639 A CN A028172639A CN 02817263 A CN02817263 A CN 02817263A CN 1551885 A CN1551885 A CN 1551885A
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- alkyl
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- SNHOZPMHMQQMNI-UHFFFAOYSA-N lithium;2h-thiophen-2-ide Chemical compound [Li+].C=1C=[C-]SC=1 SNHOZPMHMQQMNI-UHFFFAOYSA-N 0.000 description 1
- YCCXQARVHOPWFJ-UHFFFAOYSA-M magnesium;ethane;chloride Chemical compound [Mg+2].[Cl-].[CH2-]C YCCXQARVHOPWFJ-UHFFFAOYSA-M 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
- AMQFJJCJOSCKNY-UHFFFAOYSA-N methyl hydrogen sulfate;pyrazine Chemical compound COS(O)(=O)=O.C1=CN=CC=N1 AMQFJJCJOSCKNY-UHFFFAOYSA-N 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
- 239000004533 oil dispersion Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 description 1
- 229940067157 phenylhydrazine Drugs 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229910001950 potassium oxide Inorganic materials 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10143079A DE10143079A1 (de) | 2001-09-03 | 2001-09-03 | Cyclische Indol- und Heteroindolderivate, deren Herstellung und Verwendung als Arzneimittel |
| DE10143079.5 | 2001-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1551885A true CN1551885A (zh) | 2004-12-01 |
Family
ID=32239891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA028172639A Pending CN1551885A (zh) | 2001-09-03 | 2002-08-27 | 环状吲哚和杂吲哚衍生物、其作为药物的制备和用途 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1423393A1 (xx) |
| JP (1) | JP2005508898A (xx) |
| KR (1) | KR20040029463A (xx) |
| CN (1) | CN1551885A (xx) |
| AR (1) | AR036776A1 (xx) |
| BR (1) | BR0212300A (xx) |
| CA (1) | CA2458399A1 (xx) |
| HU (1) | HUP0401446A3 (xx) |
| IL (1) | IL160441A0 (xx) |
| MX (1) | MXPA04002034A (xx) |
| NO (1) | NO20040831L (xx) |
| NZ (1) | NZ531642A (xx) |
| PL (1) | PL370210A1 (xx) |
| RU (1) | RU2004110412A (xx) |
| ZA (1) | ZA200401290B (xx) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111362891A (zh) * | 2020-04-01 | 2020-07-03 | 杭州福斯特药业有限公司 | 一种乙酰基四氢呋喃的生产装置及生产方法 |
-
2002
- 2002-08-27 NZ NZ531642A patent/NZ531642A/en unknown
- 2002-08-27 MX MXPA04002034A patent/MXPA04002034A/es unknown
- 2002-08-27 BR BR0212300-2A patent/BR0212300A/pt not_active IP Right Cessation
- 2002-08-27 IL IL16044102A patent/IL160441A0/xx unknown
- 2002-08-27 JP JP2003525001A patent/JP2005508898A/ja not_active Withdrawn
- 2002-08-27 RU RU2004110412/04A patent/RU2004110412A/ru not_active Application Discontinuation
- 2002-08-27 CA CA002458399A patent/CA2458399A1/en not_active Abandoned
- 2002-08-27 KR KR10-2004-7003201A patent/KR20040029463A/ko not_active Application Discontinuation
- 2002-08-27 HU HU0401446A patent/HUP0401446A3/hu unknown
- 2002-08-27 PL PL02370210A patent/PL370210A1/xx not_active Application Discontinuation
- 2002-08-27 EP EP02767436A patent/EP1423393A1/de not_active Withdrawn
- 2002-08-27 CN CNA028172639A patent/CN1551885A/zh active Pending
- 2002-09-03 AR ARP020103329A patent/AR036776A1/es not_active Application Discontinuation
-
2004
- 2004-02-18 ZA ZA200401290A patent/ZA200401290B/en unknown
- 2004-02-25 NO NO20040831A patent/NO20040831L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111362891A (zh) * | 2020-04-01 | 2020-07-03 | 杭州福斯特药业有限公司 | 一种乙酰基四氢呋喃的生产装置及生产方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ531642A (en) | 2005-01-28 |
| RU2004110412A (ru) | 2005-03-20 |
| MXPA04002034A (es) | 2004-07-08 |
| CA2458399A1 (en) | 2003-03-13 |
| IL160441A0 (en) | 2004-07-25 |
| NO20040831L (no) | 2004-04-13 |
| EP1423393A1 (de) | 2004-06-02 |
| KR20040029463A (ko) | 2004-04-06 |
| ZA200401290B (en) | 2004-03-23 |
| PL370210A1 (en) | 2005-05-16 |
| JP2005508898A (ja) | 2005-04-07 |
| BR0212300A (pt) | 2004-10-13 |
| AR036776A1 (es) | 2004-10-06 |
| HUP0401446A2 (hu) | 2004-11-29 |
| HUP0401446A3 (en) | 2006-11-28 |
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