CN1533700A - Application of N-acetylglucosamine in dairy product and dairy product containing N-acetylglucosamine - Google Patents
Application of N-acetylglucosamine in dairy product and dairy product containing N-acetylglucosamine Download PDFInfo
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- CN1533700A CN1533700A CNA031082742A CN03108274A CN1533700A CN 1533700 A CN1533700 A CN 1533700A CN A031082742 A CNA031082742 A CN A031082742A CN 03108274 A CN03108274 A CN 03108274A CN 1533700 A CN1533700 A CN 1533700A
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- Prior art keywords
- dairy products
- acetylglucosamine
- acceptable salt
- test
- milk
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
Abstract
An application of N-acetylaminoglucose as additive in dairy products and the novel dairy products containing N-acetylaminoglucose which has health-care effect are disclosed.
Description
Technical field
The present invention relates to N-acetylglucosamine or the acceptable salt of its dairy products as the application of additive in dairy products, and comprise the dairy products of N-acetylglucosamine or the acceptable salt of its dairy products.
Background technology
Dairy products nutrition is abundant, is widely used, and is closely related with human survival, becomes the main object of nutrition research.Dairy products are also related in the formation of biology new theory naturally.Biological ripple theory is biological new theory, be on the latest developments-complexity exploration basis in contemporary physical mathematics field, actual conditions in conjunction with biology and medical science, the up-to-date biological theory of establishing, confirming by experimental study (referring to, " biological ripple Study on Theory ", China's microecology magazine, 1994,6 (6): 40-49).Biological ripple theory thinks that human body is an open system, and metabolic process is facilitated biological the dissipation with ecological unified, is carrying out the vital movement function.Biological ripple theory is applied in the nutrition, has proposed the conditional decision viewpoint of nutrient utilization, promptly biological ripple regulatory factor promotes the absorption and the utilization of nutrition.
The inventor finds uncannily that through research N-acetylglucosamine or the acceptable salt of its dairy products are compared with traditional dairy products as the novel dairy product that dairy products additive is prepared into, and has to absorb fast, good effectiveness.
Summary of the invention
An object of the present invention is to provide N-acetylglucosamine or the acceptable salt of its dairy products as the application of additive in dairy products.
Another object of the present invention provides the dairy products that comprise N-acetylglucosamine or the acceptable salt of its dairy products.
Another purpose of the present invention provides a kind of method for preparing dairy products, comprises the step that adds N-acetylglucosamine or the acceptable salt of its dairy products in the raw milk goods.
Described N-acetylglucosamine full name is N-acetyl group-D-Glucosamine (N-acetyl-D-glucosamine), and molecular formula is C
8H
15NO
6, structural formula (I) is expressed as follows:
The example that can be used for N-acetyl group of the present invention-acceptable salt of D-Glucosamine dairy products includes but not limited to: with those salt of inorganic acid formation; example hydrochloric acid salt, phosphate, hydrophosphate; and those salt that form with organic acid, as citrate, benzoate, ascorbate.
To can be used for dairy starting material of the present invention and finished product dairy products of the present invention have virtually no restriction.Dairy products of the present invention can be any type of dairy products edible usually during people live, and for example, can be liquid as liquid milk; Solid-state as milk powder, cheese; Semisolid such as sour milk, ice cream etc.Described dairy products can be common dairy products, also can be that various fortification dairy products are as adding calcium milk etc.
Adding mode in dairy products is in fact also without any restriction, as long as described adding mode has no adverse effect to other active ingredient in N-acetyl group-D-Glucosamine or acceptable salt of its dairy products and the dairy products to N-acetyl group-D-Glucosamine or the acceptable salt of its dairy products.
In one embodiment of the invention, described N-acetyl group-D-Glucosamine or the acceptable salt of its dairy products can join in the milk powder with powder type.
In another embodiment of the invention; described N-acetyl group-D-Glucosamine or the acceptable salt of its dairy products can join in the liquid dairy product; these dairy products are sold like this then, or further adopt technology well known in the art to be prepared into for example milk powder, sour milk etc.
N-acetylglucosamine or the content of the acceptable salt of its dairy products in dairy products are generally 0.001g/100ml to 10g/100ml.Be preferably 0.01g/100ml to 2g/100ml.In the weight of the solid active principle in the dairy products, N-acetylglucosamine or the content of the acceptable salt of its dairy products in dairy products are generally 0.1-10%, preferred 0.1-2%.
The novel dairy product of the N-of comprising acetylglucosamine of the present invention or the acceptable salt of its dairy products has produced the new effect useful to body, and effect is remarkable in the crowd is on probation.
The specific embodiment
Further specify the present invention and beneficial effect thereof below in conjunction with embodiment, but should be understood that these embodiment only are in order to demonstrate the invention, and not in office where face constitutes limitation of the scope of the invention.
The short ripple test of embodiment 1. formulas (I) compound
1, test material and method:
1.1 sample: the pure product of formula (I) compound.
1.2 test material:
Bacterial classification: proteus mirabilis should meet following biochemical reaction feature: power (+), urease (+), lactose (-), glucose (+), H
2S (-), PD (+).
Culture medium: improvement LB culture medium (constituent: 1% tryptone, 0.5% yeast extract, 1% sodium chloride, 0.1% glucose, 0.002%TTC, PH7.2-7.4).
1.3 test method:
To in the same old way:, cultivated 9 hours for 37 ℃ the dull and stereotyped center dibbling proteus mirabilis of LB;
The test sample: the adding final concentration is 0.5% formula (I) compound in the LB flat board, with method dibbling proteus mirabilis, cultivates 9 hours for 37 ℃.
2, result of the test and evaluation:
In in the same old way, demonstrating constantly outwards expansion, at interval 3 hours concentric ring; In the test sample, not only form the concentric ring that occurred every 3 hours, and compared with the control, on every ring, demonstrate many tiny roll-collar.
Biological wave-wave dynamic test model is adopted in this test, short ripple effect in order to research formula (I) compound, visible (I) compound biological wave characteristic that bacterial cell is acted normally as a result, and make this fluctuation show finer fluctuation mode, show that fluctuation has facilitation to formula (I) compound to biology.This short ripple effect of formula (I) compound helps to explain that the N-acetylglucosamine promotes the effect that dairy products active ingredient absorbs.
The toxicological test of embodiment 2. formulas (I) compound
Carry out the toxicological test of formula (I) compound, comprising:
1, acute toxinology experiment: comprise oral, intravenous injection and greatest limit amount medicine-feeding test;
2, Salmonella reversion test;
3, mouse marrow cell micro nuclear test;
4, the abnormal property of mouse sperm test;
5, mouse testis chromosomal aberration test;
6, chronic lethal test;
7, subchronic toxicity (feeding in 90 days) test;
8, traditional teratogenicity test;
Conclusion (of pressure testing) shows: when formula (I) compound acute toxicity test dosage surpasses 2g/kg, do not occur the acute poisoning reaction yet; In long term toxicity test, maximum dose level has reached 1g/kg, and toxic reaction does not appear in experimental observation around the warp; In reproduction test, feed mouse from routine dose 7mg/kg, go down to posterity through three times, prove formula (I) compound to mouse become pregnant, gestation, childbirth, lactation and newborn mouse growth all do not have influence.These evidence formula (I) compounds belong to innocuous substance.
Embodiment 3. animal experiments
(1) increases appetite
Adopt Kunming mouse to test.Control group oral administration gavage milk, (addition: 0.1g/100ml milk), the result observes the test group mouse cycle of looking for food and shortens, and more foods are pulverized (it is active to represent animal to look for food) to add the N-acetylglucosamine in the test group milk, food-intake increases, and body weight obviously increases.
(2) promote suckling mouse to grow
Adopt Kunming mouse to test, get female mouse of pregnancy period earlier, be divided into test group and control group.Test group oral administration gavage dairy products of the present invention (adding N-acetylglucosamine 0.1g/100g milk powder in the commercially available dried milk powder), control group oral administration gavage commercially available dried milk powder, feed until suckling mouse birth lactation 15 days, two groups of sons of weighing are for the average weight of mouse always, and test group is apparently higher than control group.
Embodiment 4. preliminary crowd's proof tests
36 volunteer crowd's tests show, with drink general milk and compare, drink dairy products of the present invention (adding N-acetylglucosamine 0.1g/100ml in the sterilising fresh milk) person and reflect that appetite increases, the good appetite, when particularly gastrointestinal disease being arranged, effect is more obvious, it is fast to drink the conscious antisecosis in back, action is strong, and the state of mind is good, efficient reaching more than 90%.
The preparation embodiment of embodiment 5. dairy products of the present invention
1. with solid form the N-acetylglucosamine is joined in the milk, making N-acetylglucosamine content is the liquid milk of 0.1g/100ml.
2. with solid form N-acetylglucosamine hydrochloride is joined in the milk, making N-acetylglucosamine content is the liquid milk of 0.1g/100ml.
3. with solid form the N-acetylglucosamine is joined in the milk powder, making N-acetylglucosamine content is the blockmilk of 0.2g/100g.
4. with solid form the N-acetylglucosamine is joined in the sour milk after the fermentation, making N-acetylglucosamine content is the sour milk of 0.1g/100ml.
5. the form with 10% weightaqueous solution joins N-acetylglucosamine citrate in the milk, and making the final content of N-acetylglucosamine is the liquid milk of 0.1g/100ml.
Observation to above-mentioned dairy products is found, adds N-acetylglucosamine or its salt and the outward appearance of dairy products is not produced obviously influence.
Claims (7)
1.N-acetylglucosamine or the acceptable salt of its dairy products are as the application of additive in dairy products.
2. the application of claim 1, wherein N-acetylglucosamine or the acceptable salt of its dairy products add the powder dairy products to.
3. the application of claim 1, wherein N-acetylglucosamine or the acceptable salt of its dairy products add in the liquid diary product.
4. each application among the claim 1-3, wherein N-acetylglucosamine or the content of the acceptable salt of its dairy products in dairy products are 0.001g/100ml to 10g/100ml.
5. the dairy products that comprise N-acetylglucosamine or the acceptable salt of its dairy products.
6. the dairy products of claim 5, wherein N-acetylglucosamine or the content of the acceptable salt of its dairy products in dairy products are 0.001g/100ml to 10g/100ml.
7. a method for preparing dairy products comprises the step that adds N-acetylglucosamine or the acceptable salt of its dairy products in the raw milk goods.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031082742A CN100339014C (en) | 2003-03-27 | 2003-03-27 | Application of N-acetylglucosamine in dairy product and dairy product containing N-acetylglucosamine |
| PCT/CN2004/000279 WO2004093556A1 (en) | 2003-03-27 | 2004-03-29 | The use of n-acetyl glucosamine as additive in milk products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031082742A CN100339014C (en) | 2003-03-27 | 2003-03-27 | Application of N-acetylglucosamine in dairy product and dairy product containing N-acetylglucosamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1533700A true CN1533700A (en) | 2004-10-06 |
| CN100339014C CN100339014C (en) | 2007-09-26 |
Family
ID=33304435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031082742A Expired - Fee Related CN100339014C (en) | 2003-03-27 | 2003-03-27 | Application of N-acetylglucosamine in dairy product and dairy product containing N-acetylglucosamine |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN100339014C (en) |
| WO (1) | WO2004093556A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072653A (en) * | 2015-05-02 | 2016-11-09 | 邓渝 | The vegetable protein beverage of 2-Acetamido-2-deoxy-D-glucose and application thereof |
| CN106333314A (en) * | 2015-07-09 | 2017-01-18 | 邓渝 | Application of N-acetylglucosamine to honey product and honey product containing N-acetylglucosamine |
| CN110367335A (en) * | 2019-08-30 | 2019-10-25 | 江西阳光乳业股份有限公司 | A kind of preparation method of health Yoghourt |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2918376B1 (en) | 2007-07-04 | 2011-10-28 | Mathieu Borge | LIQUID OR PASSIZED COMPOSITIONS FOR THE CONTRIBUTION OF ESSENTIAL ELEMENTS TO THE SYNTHESIS AND CONSTITUTION OF PROTEOGLYCANS, IN PARTICULAR FOR THE TREATMENT OF CARTILAGE DEGRADATION |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1519555A (en) * | 1966-07-26 | 1968-04-05 | Expl Des Etablissements Larous | Dietetic product for weaned infants |
| FR2101030A1 (en) * | 1970-08-11 | 1972-03-31 | Sogeras | New biogical bifidogene complex - useful as infant diet supplement |
| US3677949A (en) * | 1970-09-04 | 1972-07-18 | Enthone | Selectively stripping tin and/or lead from copper substrates |
| IL128335A0 (en) * | 1996-08-09 | 2000-01-31 | Mannatech Inc | Compositions of plant carbohydrates as dietary supplements |
| CN1095366C (en) * | 1996-12-27 | 2002-12-04 | 中国人民解放军第三军医大学 | Application of N-aceto-D-aminoglucose in medicinal preparation for curing intestinal diseases |
| WO2003012074A2 (en) * | 2001-07-30 | 2003-02-13 | Den Kgl. Veterinær- Og Landbohøjskole | Bacterial strains belonging to lactobacillus species and their use in food and feed industry |
-
2003
- 2003-03-27 CN CNB031082742A patent/CN100339014C/en not_active Expired - Fee Related
-
2004
- 2004-03-29 WO PCT/CN2004/000279 patent/WO2004093556A1/en active Application Filing
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072653A (en) * | 2015-05-02 | 2016-11-09 | 邓渝 | The vegetable protein beverage of 2-Acetamido-2-deoxy-D-glucose and application thereof |
| CN106333314A (en) * | 2015-07-09 | 2017-01-18 | 邓渝 | Application of N-acetylglucosamine to honey product and honey product containing N-acetylglucosamine |
| CN110367335A (en) * | 2019-08-30 | 2019-10-25 | 江西阳光乳业股份有限公司 | A kind of preparation method of health Yoghourt |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004093556A1 (en) | 2004-11-04 |
| CN100339014C (en) | 2007-09-26 |
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| ASS | Succession or assignment of patent right |
Owner name: SUZHOU CITY BAWEI CHINESE MEDICINE DEVELOPMENT RE Effective date: 20050422 |
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| TA01 | Transfer of patent application right |
Effective date of registration: 20050422 Address after: Chongqing city Shapingba street 400038 gaotanyan No. 30 Applicant after: Third Military Medical University, Chinese People's Liberation Army Co-applicant after: Suzhou Bawei Medicine Development Research Institute Co., Ltd. Co-applicant after: Beijing Hong Kong Fu biological wave Technology Co. Ltd. Address before: Chongqing city Shapingba street 400038 gaotanyan No. 30 Applicant before: Third Military Medical University, Chinese People's Liberation Army |
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Granted publication date: 20070926 Termination date: 20120327 |