CN1534089A - Application of N-acetylglucosamine as additive of grape wine and grape wine containing N-acetylglucosamine - Google Patents
Application of N-acetylglucosamine as additive of grape wine and grape wine containing N-acetylglucosamine Download PDFInfo
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- CN1534089A CN1534089A CNA031082750A CN03108275A CN1534089A CN 1534089 A CN1534089 A CN 1534089A CN A031082750 A CNA031082750 A CN A031082750A CN 03108275 A CN03108275 A CN 03108275A CN 1534089 A CN1534089 A CN 1534089A
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- grape wine
- acetylglucosamine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G1/00—Preparation of wine or sparkling wine
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Abstract
An application of N-acetylaminoglucose or its derivative receptable to wine in grape wine and the process for preparing said grape wine are disclosed. It features that the damage of the harmful substances, such as alcohol, in the grape wine to human organs can be reduced by more than 95%.
Description
Technical field
The present invention relates to N-acetylglucosamine or its drinks goods acceptable derivates as the application of additive in grape wine, comprise the grape wine of N-acetylglucosamine or its drinks goods acceptable derivates and prepare method vinous.
Technical background
It has been generally acknowledged that the influence of drinking to human body has dual character.Responsible drinking can be relaxed the muscles and stimulate the blood circulation, and increases energy, and has report to propose and can preventive and therapeutic effect be arranged to cardiovascular disorder.But so-called responsible drinking is difficult to hold really, and the individuality afterreaction of drinking differs.The common sympton of excessive consumption of alcohol have dizziness, headache, dizzy, nauseating, vomiting, appetite not just, the back malaise of drinking, outward appearance symptom such as thirsty; Alcohol exerts an influence with configuration, conformation of its fat-soluble and wetting ability cell membrane lipid and membranin and causes damage to body tissue, is more common in the damage of liver and cardiovascular and cerebrovascular greatly.The mankind have carried out a large amount of exploration with reducing to injury of human for the traditional habit of drinking of taking into account people, but concentrate on mostly in wine preparation technology's the transformation, also have plenty of to add some Chinese medicinal materialss in wine, to attempt to improve the quality of wine, reduce the human influence.
Remove the mode of improving wine quality of fusel in the course of processing of wine, but this just reduces the influence of alcohol composition in addition to body to a certain extent for seeing more.Prevent that ethanol from being to reduce alcoholic acid content to the method for body injury, this has played some positive effects to a certain extent.But ethanol enters behind the human body particularly when its amount of drinking surpasses certain limit, the damage of body is remained very tangible, no matter this is not always the case in liquor, grape wine or beer.
Other has a class job is to add the Chinese medicinal materials that health-care effect is arranged in wine.This drinks is purpose with wine as the carrier of medicine rather than to subdue the damage of drinking in fact just.
Have now found that, drink grape wine when excessive the reaction of cranial nerve more obvious.This be since in the grape wine impurity such as acetone strong to body cell avidity, the work of suppressed to relieve the effect of alcohol in the body system or enzyme.The inventor chances in research work, after being added on N-acetylglucosamine or its drinks goods acceptable derivates in the grape wine with suitable proportion, drink, the crowd tests the dizzy symptom of reflection and significantly alleviates, drunk reaction does not take place or increases the tardy life of the amount of drinking pusher, and can drink the follow-up drunk reaction after the grape wine effectively gently, as thirsty, language performance is not good and uncomfortable reaction such as general weakness.
The inventor has set up the model of biological fluctuation growth in carrying out biological ripple theoretical investigation, and has further furtherd investigate the molecular mechanism of biological fluctuation growth, and the changing little allos of biological ripple that has proposed biological organism changes principle.The change degree of external environment is depended in the speed faster or slower that biological ripple changes.After body was accepted objectionable impurities and stimulated, rapid variation had appearred in interior environment, facilitates little heterology to take place, and made between body and the environment unbalancely, caused partial damage or whole body toxicity symptom.The appearance of this damage and toxicity symptom is analyzed from the molecular biology angle, be since the particularly various enzymes of albumen under altered condition, particularly under temperature change and the microbial metabolites existence condition, functional lability even afunction.
The back liver cell metabolism of drinking is suppressed, and nonspecific inflammation takes place, and merocrine secretion's thing increases, cell enlargement even become turbid swollen or downright bad.It is believed that the N-acetylglucosamine is as a biological ripple regulatory factor, the vibration that can stablize macromolecular substance, keeping the physiology vibration ceaselessly carries out, slow down and repel the influence of the unfavorable factor of body existence, thereby keep the particularly physiological function of various enzymes of albumen, lower the damage of drinking.
The measure and the medicine that do not have at present control effectively to drink and damage as yet.In this case, the inventor finds that uncannily N-ethanoyl-D-glucosamine or its drinks goods acceptable derivates can effectively reduce the damage of drinking as the novel grape wine that additive preparation becomes.
Summary of the invention
An object of the present invention is to provide N-acetylglucosamine or its drinks goods acceptable derivates as the application of additive in grape wine.
Another object of the present invention provides the grape wine that comprises N-acetylglucosamine or its drinks goods acceptable derivates.
Another purpose of the present invention provides a kind of preparation method vinous, comprises in raw material grape wine adding N-acetylglucosamine or its drinks goods acceptable derivates with preparation finished product step vinous.
Full name of described N-acetylglucosamine is N-ethanoyl-D-glucosamine, and molecular formula is C
8H
15NO
6, structural formula (I) is expressed as follows:
The example that can be used for the drinks goods acceptable derivates of N-ethanoyl-D-glucosamine of the present invention includes but not limited to: with the salt of mineral acid formation; example hydrochloric acid salt, phosphoric acid salt, hydrophosphate; and the salt that forms with organic acid, as Citrate trianion, benzoate, ascorbate salt.
N-ethanoyl-D-glucosamine or its drinks goods acceptable derivates generally can directly join and be prepared into finished product grape wine in the raw material grape wine.Perhaps, N-ethanoyl-D-glucosamine or its drinks goods acceptable derivates can join with the form of the aqueous solution in the raw material grape wine.Perhaps, N-ethanoyl-D-glucosamine or its drinks goods acceptable derivates can be formed packaged in combination with grape wine, join in the grape wine before drinking person is drunk.
The grape wine that is applicable to the object of the invention can be any grape wine, for example normal juice vine wine, distillation grape wine such as dry red winew, Dry white wine etc.
N-acetylglucosamine or the content of its drinks goods acceptable derivates in grape wine can be 0.001g/100ml to 10g/100ml, are preferably 0.01g/100ml to 5g/100ml.
N-acetylglucosamine or its drinks goods acceptable derivates are applied in the grape wine as additive, and objectionable impurities such as ethanol is to the infringement of body, efficient reaching more than 95% in the may command grape wine.
Embodiment
Further specify the present invention and beneficial effect thereof below in conjunction with embodiment, but should be understood that these embodiment only are in order to demonstrate the invention, and not in office where face constitutes limitation of the scope of the invention.
The short ripple test of embodiment 1. formulas (I) compound
1, test materials and method:
1.1 sample: the pure product of formula (I) compound.
1.2 test materials:
Bacterial classification: Proteus mirabilis should meet following biochemical reaction feature: power (+), urease (+), lactose (-), glucose (+), H
2S (-), phenylalanine deaminase (+).
Substratum: improvement LB substratum (moiety: 1% Tryptones, 0.5% yeast extract, 1% sodium-chlor, 0.1% glucose, 0.002%TTC, PH7.2-7.4).
1.3 test method:
To in the same old way:, cultivated 9 hours for 37 ℃ the dull and stereotyped center dibbling Proteus mirabilis of LB;
The test sample: the adding final concentration is 0.5% formula (I) compound in the LB flat board, with method dibbling Proteus mirabilis, cultivates 9 hours for 37 ℃.
2, test-results and evaluation:
In in the same old way, demonstrating constantly outwards expansion, at interval 3 hours concentric ring; In the test sample, not only form the concentric ring that occurred every 3 hours, and compared with the control, on every ring, demonstrate many tiny roll-collar.
Biological wave-wave dynamic test model is adopted in this test, short ripple effect in order to research formula (I) compound, visible (I) compound biological wave characteristic that bacterial cell is acted normally as a result, and make this fluctuation show finer fluctuation mode, show that fluctuation has promoter action to formula (I) compound to biology.This short ripple effect helps to explain the effect of damaging after N-acetylglucosamine or the control of its drinks goods acceptable derivates are drunk.
The toxicological test of embodiment 2. formulas (I) compound
Carry out the toxicological test of formula (I) compound, comprising:
1, acute toxinology experiment: comprise oral, intravenous injection and greatest limit amount medicine-feeding test;
2, Salmonella reversion test;
3, mouse marrow cell micro nuclear test;
4, the abnormal property of mouse sperm test;
5, mouse testis chromosomal aberration test;
6, chronic lethal test;
7, subchronic toxicity (feeding in 90 days) test;
8, traditional teratogenicity test;
Conclusion (of pressure testing) shows: when formula (I) compound acute toxicity test dosage surpasses 2g/kg, do not occur the acute poisoning reaction yet; In long term toxicity test, maximum dose level has reached 1g/kg, and toxic reaction does not appear in experimental observation around the warp; In reproduction test, feed mouse from routine dose 7mg/kg, go down to posterity through three times, prove formula (I) compound to mouse become pregnant, gestation, childbirth, lactation and newborn mouse growth all do not have influence.These evidence formula (I) compounds belong to non-toxic substance.
Embodiment 3. animal experiments
Adopt commercially available grape wine (alcoholic strength 12 degree) that the control group small white mouse is irritated stomach; (be the dregs of grape wine precision: content 0.1% weight of 12 degree and N-acetylglucosamine) the test group small white mouse is irritated stomach, each 30 small white mouse is tested for test group and control group to adopt grape wine of the present invention.When irritating stomach with the dosage of 0.2ml/20g/ time (being that each 20 gram mouse body weight are irritated the 0.2ml grape wine), added in per 10 minutes and to feed once, as a result control group mice in 1 hour 18 faint, lose consciousness 9 astasias, 3 death; 2 mouse stupors when test group reaches this dosage, the state of slight astasia appears in 4 mouse, and all the other mouse states are normal substantially.Control group and test group difference as a result are bigger.
Embodiment 4. tests drunk by people
50 routine human bodies are on probation, and the amount of drinking is the individual routine amount of drinking, and 50 milliliters are not waited to 500 milliliters.Test grape wine is formed: the N-acetylglucosamine that adds 0.1% weight in the commercially available grape wine.The trier generally reacts better, wherein has 45 people reflection not dizzy, comprises that the 23 people reflection drunk reaction in back of drinking is lighter, and total effective rate is more than 90%.
Adopt the N-acetylglucosamine of commercially available grape wine+0.2% weight to test, obtain analog result, wherein 48 people reflection is not dizzy, comprises that the 35 people reflection drunk reaction in back of drinking is lighter, and total effective rate is more than 96%.
Adopt the N-acetylglucosamine hydrochloride of commercially available grape wine+0.1% weight to test, obtain analog result, wherein 46 people reflection is not dizzy, comprises that the 23 people reflection drunk reaction in back of drinking is lighter, and total effective rate is more than 92%.
Claims (9)
1.N-acetylglucosamine or its drinks goods acceptable derivates are as the application of additive in grape wine.
Right require 1 application, wherein will the N-acetylglucosamine or its drinks goods acceptable derivates add in the wine body and be prepared into novel wine product.
Right require 1 application, wherein before drinking grape wine, N-acetylglucosamine or its drinks goods acceptable derivates are added in the grape wine.
4. each application among the claim 1-3, wherein N-acetylglucosamine or the content of its drinks goods acceptable derivates in grape wine are 0.001g/100ml to 10g/100ml.
5. the application of claim 4, wherein N-acetylglucosamine or the content of its drinks goods acceptable derivates in grape wine are 0.01g/100ml to 5g/100ml.
6. the grape wine that comprises N-acetylglucosamine or its drinks goods acceptable derivates.
7. the grape wine of claim 6, wherein N-acetylglucosamine or the content of its drinks goods acceptable derivates in grape wine are 0.001g/100ml to 10g/100ml.
8. the grape wine of claim 7, wherein N-acetylglucosamine or the content of its drinks goods acceptable derivates in grape wine are 0.01g/100ml to 5g/100ml.
9. one kind prepares method vinous, comprises in raw material grape wine adding N-acetylglucosamine or its drinks goods acceptable derivates with preparation finished product step vinous.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031082750A CN1534089A (en) | 2003-03-27 | 2003-03-27 | Application of N-acetylglucosamine as additive of grape wine and grape wine containing N-acetylglucosamine |
| PCT/CN2004/000274 WO2004085604A1 (en) | 2003-03-27 | 2004-03-29 | The use of n-acetyl glucosamine as additive in wine and wine comprising n-acetyl glucosamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031082750A CN1534089A (en) | 2003-03-27 | 2003-03-27 | Application of N-acetylglucosamine as additive of grape wine and grape wine containing N-acetylglucosamine |
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| Publication Number | Publication Date |
|---|---|
| CN1534089A true CN1534089A (en) | 2004-10-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031082750A Pending CN1534089A (en) | 2003-03-27 | 2003-03-27 | Application of N-acetylglucosamine as additive of grape wine and grape wine containing N-acetylglucosamine |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN1534089A (en) |
| WO (1) | WO2004085604A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102199513A (en) * | 2011-03-01 | 2011-09-28 | 邱阳 | Oxidation resistant health wine |
| CN106072653A (en) * | 2015-05-02 | 2016-11-09 | 邓渝 | The vegetable protein beverage of 2-Acetamido-2-deoxy-D-glucose and application thereof |
| CN106333314A (en) * | 2015-07-09 | 2017-01-18 | 邓渝 | Application of N-acetylglucosamine to honey product and honey product containing N-acetylglucosamine |
| CN112375633A (en) * | 2020-11-26 | 2021-02-19 | 江苏双林海洋生物药业有限公司 | Glucosamine wine and preparation method thereof |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1210038C (en) * | 2003-03-27 | 2005-07-13 | 中国人民解放军第三军医大学 | Application of N-acetylglucosamine in the preparation of medicine for treating viscera injure due to toxication from poison and medicine |
| FR2918376B1 (en) | 2007-07-04 | 2011-10-28 | Mathieu Borge | LIQUID OR PASSIZED COMPOSITIONS FOR THE CONTRIBUTION OF ESSENTIAL ELEMENTS TO THE SYNTHESIS AND CONSTITUTION OF PROTEOGLYCANS, IN PARTICULAR FOR THE TREATMENT OF CARTILAGE DEGRADATION |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1049006C (en) * | 1996-12-27 | 2000-02-02 | 中国人民解放军第三军医大学 | Health-care wine using N-acetyl-D-aminoglucose as additives |
-
2003
- 2003-03-27 CN CNA031082750A patent/CN1534089A/en active Pending
-
2004
- 2004-03-29 WO PCT/CN2004/000274 patent/WO2004085604A1/en active Application Filing
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102199513A (en) * | 2011-03-01 | 2011-09-28 | 邱阳 | Oxidation resistant health wine |
| CN106072653A (en) * | 2015-05-02 | 2016-11-09 | 邓渝 | The vegetable protein beverage of 2-Acetamido-2-deoxy-D-glucose and application thereof |
| CN106333314A (en) * | 2015-07-09 | 2017-01-18 | 邓渝 | Application of N-acetylglucosamine to honey product and honey product containing N-acetylglucosamine |
| CN112375633A (en) * | 2020-11-26 | 2021-02-19 | 江苏双林海洋生物药业有限公司 | Glucosamine wine and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| WO2004085604A1 (en) | 2004-10-07 |
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| ASS | Succession or assignment of patent right |
Owner name: SUZHOU CITY BAWEI CHINESE MEDICINE DEVELOPMENT RE Effective date: 20050422 |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20050422 Address after: Chongqing city Shapingba street 400038 gaotanyan No. 30 Applicant after: Third Military Medical University, Chinese People's Liberation Army Co-applicant after: Suzhou Bawei Medicine Development Research Institute Co., Ltd. Co-applicant after: Beijing Hong Kong Fu biological wave Technology Co. Ltd. Address before: Chongqing city Shapingba street 400038 gaotanyan No. 30 Applicant before: Third Military Medical University, Chinese People's Liberation Army |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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