CN1515311A

CN1515311A - Blood-lipid-reducing thrombolytic medicine

Info

Publication number: CN1515311A
Application number: CNA2003101173086A
Authority: CN
Inventors: 张小朋
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-12-08
Filing date: 2003-12-08
Publication date: 2004-07-28
Anticipated expiration: 2023-12-08
Also published as: CN1185007C

Abstract

The present invention relates to a Chinese medicine for curing hyperlipemia, reducing blood viscosity and preventing and curing coronary heart disease and cerebral embolism. Its composition includes 10 Chinese medicinal materials of capillaris, crataegus fruit, flowery knotweed, salvia root, mistletoe and others, and its preparation method adopts the following steps: proportioning and mixing all the Chinese medicinal materials, pulverizing, decocting for 30-80 min, removing residue to obtain aqueous preparation, also further concentrating it and making it into granules preparation or pill or capsule with obvious therapeutic effect.

Description

Blood-lipid-reducing thrombolytic medicine

The present invention relates to a kind of medicine for the treatment of hyperlipidemia, prevention and treatment cardiovascular and cerebrovascular disease, particularly is medicine of raw material for treating hyperlipidemia, prevention and treatment cerebral embolism, coronary heart disease and preparation method thereof with the Chinese herbal medicine.

Now, development along with society, living standards of the people improve constantly, the increase of higher fatty acid, high protein intake, cause cardiovascular and cerebrovascular disease sickness rate such as hyperlipidemia, hypertension, cerebral embolism, coronary heart disease to be continuous ascendant trend, sickness rate height among the crowd, the healing difficulty is big, has had a strong impact on patient's quality of life.Though at present existing part Western medicine has certain curative effect to above-mentioned disease,, many patients can not adhere to treatment because the Western medicine cost is higher, side effect is big.The traditional Chinese medical science, Chinese herbal medicine are the national rarities of China, and developing is traditional Chinese medical science worker's responsibility.I in the process of practising medicine for many years, summed up with the Chinese herbal medicine be that cost of material is cheap, curative effect is outstanding, the medicine of several treatment hyperlipidemia that have no side effect, prevention and treatment cerebral embolism, coronary heart disease.

One aspect of the present invention relates to the Chinese herbal medicine compositions, it contains the various herb ingredients of following proportioning (by weight): Herba Artemisiae Scopariae 10-30, Fructus Crataegi 10-30, Radix Polygoni Multiflori 10-30, Radix Salviae Miltiorrhizae 10-30, Herba Taxilli 10-30, Cherokee rose 10-30, Hirudo 5-10, Semen Cassiae 10-50, Herba Bidentis Bipinnatae 10-30, Herba Erodii 10-50.

The preferred proportioning of pharmaceutical composition is: Herba Artemisiae Scopariae 10-25, Fructus Crataegi 10-25, Radix Polygoni Multiflori 10-30, Radix Salviae Miltiorrhizae 15-30, Herba Taxilli 10-25, Cherokee rose 10-25, Hirudo 5-10, Semen Cassiae 10-40, Herba Bidentis Bipinnatae 15-30, Herba Erodii 15-40.

The preferred proportioning of pharmaceutical composition is: Herba Artemisiae Scopariae 15-20, Fructus Crataegi 15-20, Radix Polygoni Multiflori 15-30, Radix Salviae Miltiorrhizae 20-30, Herba Taxilli 10-20, Cherokee rose 10-20, Hirudo 5-10, Semen Cassiae 15-40, Herba Bidentis Bipinnatae 15-30, Herba Erodii 20-40.

The proportioning that pharmaceutical composition is more preferably is: Herba Artemisiae Scopariae 15-20, Fructus Crataegi 15-20, Radix Polygoni Multiflori 15-25, Radix Salviae Miltiorrhizae 15-25, Herba Taxilli 15-20, Cherokee rose 15-20, Hirudo 5-10, Semen Cassiae 15-30, Herba Bidentis Bipinnatae 15-25, Herba Erodii 25-40.

The most preferred proportioning of pharmaceutical composition is: Herba Artemisiae Scopariae 20, Fructus Crataegi 20, the Radix Polygoni Multiflori 25, Radix Salviae Miltiorrhizae 25, Herba Taxilli 20, Cherokee rose 20, Hirudo 8, Semen Cassiae 30, Herba Bidentis Bipinnatae 25, Herba Erodii 40.

The invention still further relates to treatment hyperlipidemia, prevention and the treatment cerebral embolism of making by the said herbal medicine pharmaceutical composition, the medicine of coronary heart disease.Medicine can be water preparation, granule, pill or capsule.The present invention relates to above-mentioned composition and be used to prepare the purposes for the treatment of hyperlipidemia, prevention and treatment coronary heart disease and cerebral embolism medicine.

The present invention also relates to prepare the method for medicine, it comprises the steps: to take by weighing in proportion Herba Artemisiae Scopariae, Fructus Crataegi, the Radix Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Taxilli, Cherokee rose, Hirudo, Semen Cassiae, Herba Bidentis Bipinnatae, Herba Erodii (Herba Erodii), pulverize, decocting boiled 30-80 minute, filter and remove residue, sterilization liquid medicine, vacuum filling makes water preparation, perhaps further concentrates liquid medicine and makes granule or pill or capsule.

The main pathological basis of cardiovascular and cerebrovascular disease is blood viscosity height, hyperlipidemia and atherosclerosis, causes lumen of vessels narrow, cerebral ischemia, even vascular occlusion and cause the focal thromboembolism of brain.Before morbidity, abdominal distention, constipation, belch, acid regurgitation, stuffy sensation with restlessness are in the heart arranged more.First bluish lip purple, obesity, cough with copious phlegm, moving then asthma, pain between brain, limbs are numb, dark tongue quality, yellow fur, white greasy, stringy and thready pulse stringy and rolling pulse etc.

Characteristics of the present invention are to select in the Chinese medicine at the blood fat height, thereby blood viscosity is high and have blood fat reducing, blood viscosity lowering, thrombolytic composition reasonable compatibility and reach the control hyperlipidemia, lower blood viscosity, the effect of prevention and treatment cardiovascular and cerebrovascular disease.Radix Polygoni Multiflori slightly warm in nature in the side, bitter and puckery flavor is gone into the Liver and kidney warp, energy bone and muscle strengthening benefit arteries and veins, these product of clinical trial have blood fat reducing, alleviate the atherosclerosis effect, recover blood vessel elasticity.Herba Taxilli, Cherokee rose tonifying liver and kidney and strengthening bones and muscles, controlling nocturnal emission with astringent drugs is filled out marrow; Radix Salviae Miltiorrhizae, Fructus Crataegi, Hirudo blood circulation promoting and blood stasis dispelling go trusted subordinate's obstinate disease, tonneau venation, promoting digestion and removing stagnation, the source that the turbid carbuncle of the heat-phlegm that dries is long-pending.Herba Artemisiae Scopariae, Semen Cassiae, Herba Bidentis Bipinnatae, Herba Erodii clearing away heat-damp and promoting diuresis dispel the wind, and make the pathogen part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels and go, and excrete, and heresy has outlet.All medicine compatibilities are blamed the kidney invigorating altogether and are helped spleen, the stagnant effect of heat clearing away, reach blood fat reducing, the dual curative effect of thrombolytic, are the desirable medicines of treatment hyperlipidemia, prevention and treatment coronary heart disease and cerebral embolism.

Each Chinese medicine ingredients of above-mentioned prescription belongs to basis, still can increase the Chinese medicine ingredients that other have auxiliary effect on its basis.

Make medicine with above-mentioned prescription, take for numerous hyperlipidemia, cardio-cerebral vascular disease patient, effect is very outstanding, and is rapid-action, blood fat reduced to normally in the earliest 7 days, and effective percentage is more than 90%, and the user poison of any discomfort all do not occur and pays effect.

Be a part of example that proof the present invention has outstanding curative effect below:

1. No. 73 Li Jun light in Taibei City, Taiwan Dong Yuan road and No. 16 Du Jin Mr.s Rong Liangwei in No. 29 building of Taibei city unitization Lu Erqu organize 50 hyperlipidemia people to take medicine of the present invention, twice of every day, each one jar, every jar of 75ml medicinal liquid, 10 days is a course of treatment, takes 30 days, and blood fat all obviously descends, the blood viscosity index is significantly improved, effective percentage 100%; After wherein a people took medicine 7 days because other reasons when carrying out blood testing, finds that blood fat has recovered normal.

2. Hong Kong Yulong International investment company organizes 100 people to take the medicine of the present invention of granule dosage form or capsule formulation, and wherein 90 people suffer from hyperlipidemia and hypertension, takes 1-3 the course of treatment, and all effectively, blood fat and blood pressure all drops to normal or approaching normal; 6 people have cerebral thrombosis, take 2-5 the course of treatment, and the hemiplegia of limb symptom obviously alleviates, and CT shows that cerebral infarct size reduces; 4 people are hyperlipidemia not only, also suffers from coronary atherosclerosis, and angina pectoris attacks is once arranged, and is diagnosed as coronary heart disease, and electrocardiogram shows myocardial ischemia, and coronary insufficiency after several courses of treatment of taking medicine, the outbreak of heart strand all do not occur again, and 3 people's electrocardiograms are set one's heart the disappearance of myocardial ischemia sign.

3. the Guo Dian of Xinzheng City opens in the township villager Zhang Ming, and it is unclear to fall down the back brain mind in winter in 2002, and dysphonia can not be stood.Took this medicine 7 days, Consciousness, it is normal to talk, walk.To the People's Hospital, Xinzheng City chemical examination blood fat, wherein triglyceride continued to take this medicine 20 days still up to 7.4mmol/L, chemical examination again, and triglyceride drops to 3.2mmol/L.

4. Henan Province faces chin or cheek Lin Qu township, county merchant Xu Wang village peasant Jia Sanwang, and in May, 2002, morbidity was mute, can not sit the station, takes a turn for the better through facing the 10 days nothings in chin or cheek county hospital, county.On October 23rd, 2002 rose and took this medicine 10 days, and the walking of leaving the bed continued medication treatment 40 days, and symptom disappears substantially.

5. the Zhang Baidao of Huai Yang county, Zhoukou City, Henan Province building constructor, 56 years old, 1996 " accidentally " fell down, and is diagnosed as cerebral embolism through county hospital, can speak in 3 months, can sit in hospitalize, but can not walk.On July 2nd, 2003 rose and took this medicine 53 days, can walk with descending.

More than some examples show that medicine of the present invention is not only treated hyperlipidemia, blood viscosity lowering, prevention of arterial is atherosis, can also effectively prevent and treat coronary heart disease, cerebral embolism.

Claims

1. Chinese medicine composition for the treatment of hyperlipidemia or prevention and treatment coronary heart disease or cerebral embolism is characterized in that containing following medicinal herb components by weight ratio:

Herba Artemisiae Scopariae 10-30, Fructus Crataegi 10-30, Radix Polygoni Multiflori 10-30, Radix Salviae Miltiorrhizae 10-30, Herba Taxilli 10-30, Cherokee rose 10-30, Hirudo 5-10, Semen Cassiae 10-50, Herba Bidentis Bipinnatae 10-30, Herba Erodii 10-50.

2. medicine according to claim 1, wherein each composition proportion is:

Herba Artemisiae Scopariae 10-25, Fructus Crataegi 10-25, Radix Polygoni Multiflori 10-30, Radix Salviae Miltiorrhizae 15-30, Herba Taxilli 10-25, Cherokee rose 10-25, Hirudo 5-10, Semen Cassiae 10-40, Herba Bidentis Bipinnatae 15-30, Herba Erodii 15-40.

3. compositions according to claim 1 and 2, wherein each composition proportion is:

Herba Artemisiae Scopariae 15-20, Fructus Crataegi 15-20, Radix Polygoni Multiflori 15-30, Radix Salviae Miltiorrhizae 20-30, Herba Taxilli 10-20, Cherokee rose 10-20, Hirudo 5-10, Semen Cassiae 15-40, Herba Bidentis Bipinnatae 15-30, Herba Erodii 20-40.

4. compositions according to claim 1 and 2, wherein each composition proportion is:

Herba Artemisiae Scopariae 15-20, Fructus Crataegi 15-20, Radix Polygoni Multiflori 15-25, Radix Salviae Miltiorrhizae 15-25, Herba Taxilli 15-20, Cherokee rose 15-20, Hirudo 5-10, Semen Cassiae 15-30, Herba Bidentis Bipinnatae 15-25, Herba Erodii 25-40.

5. compositions according to claim 1 and 2, wherein each composition proportion is:

Herba Artemisiae Scopariae 20, Fructus Crataegi 20, the Radix Polygoni Multiflori 25, Radix Salviae Miltiorrhizae 25, Herba Taxilli 20, Cherokee rose 20, Hirudo 8, Semen Cassiae 30, Herba Bidentis Bipinnatae 25, Herba Erodii 40.

6. the arbitrary described compositions of claim 1-5 is preparing the purposes for the treatment of in the high blood cholesterol drug.

7. the purposes of the arbitrary described compositions of claim 1-5 in preparation prevention or treatment cerebral embolism medicine.

8. the purposes of the arbitrary described compositions of claim 1-5 in preparation prevention or treatment medicaments for coronary disease.

9. treat the medicine of hyperlipidemia or prevention and treatment coronary heart disease or cerebral embolism, it contains each described compositions of claim 1-5.

10. the described medicine of claim 9, it is water preparation or granule or pill or capsule formulation.

11. the preparation method of the described medicine of claim 9, take by weighing Herba Artemisiae Scopariae, Fructus Crataegi, the Radix Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Taxilli, Cherokee rose, Hirudo, Semen Cassiae in proportion, Herba Bidentis Bipinnatae, Herba Erodii, pulverize, decocting boiled 30-80 minute, filter and remove residue, sterilization liquid medicine, vacuum filling makes water preparation, perhaps further concentrates liquid medicine and makes granule or pill or capsule.