CN1513484A

CN1513484A - Traditional chinese medicine for treating postpartum diseases

Info

Publication number: CN1513484A
Application number: CNA021455708A
Authority: CN
Inventors: 魏文利
Original assignee: Individual
Current assignee: Individual
Priority date: 2002-12-31
Filing date: 2002-12-31
Publication date: 2004-07-21
Anticipated expiration: 2022-12-31
Also published as: CN1253202C

Abstract

A Chinese medicine for treating the puerperal diseases of woman, such as lochia and abdominalgia, is prepared from 6 Chinese-medicinal materials including motherwort, Chinese angelica root, peach kernel, Chuan-xiong rhizome, etc. Its advantage is high curative effect.

Description

A kind of Chinese medicine that is used for the treatment of woman postpartum disease

Content of the present invention belongs to the preparing technical field of pharmaceuticals, relates to a kind of pure Chinese medicinal preparation that can be used for treating various disease conditions such as lochia due to women's QI and blood deficiency in puerperal, the blood-stasis internal-depression, stomachache and preparation method thereof.

Puerperal disease is a clinical very common class obstetrical and gynecological disease, cloudy blood consumption owing to impairment caused by overstrain in the birth process, due to perspiring, lose blood etc. is hindered, reasons such as void, weakened defensive QI are lost in vigour loss, healthy energy, the turbid liquid stasis of blood of surplus blood in puerperal stagnates in addition, afterbirth is residual causes influencing each other of multiple factor such as blood-stasis internal-depression, the puerpera is very easily suffered from such as various disease conditions such as not smooth not well, the spiritlessness and weakness of lochia, stomachache, lochia, deficiency of QI with disinclination to talk, spontaneous perspiration, milk rareness, pallor be simple and unadorned, had a strong impact on the healthy of postpartum women.In view of all there is the childbirth of more than one hundred million women (wherein China has nearly 20,000,000 every year at least) experience every year the world today, the puerperal disease vulnerable crowd is very huge, and therefore, it is significant actively to prevent and treat puerperal disease effectively.

Motherland's medical science is paid attention to the research and the practice of obstetrics from ancient times, has accumulated profuse experience aspect the preventing and treating of puerperal disease, and has also formed unique curative effect advantage simultaneously.Puerpera and baby's harmful effect is exempted or alleviated to Chinese medicine with its significant clinical efficacy and good safety, thereby favored by numerous patients and doctor family for a long time always.Deepening continuously and the development of industrialization of Chinese medicine process along with Chinese medicine research in recent years, the domestic new Chinese medicine of having developed multiple control puerperal disease in succession, make this area clinical application situation that very big change arranged, but because puerperal disease morbidity case is many and pathomechanism is comparatively complicated, existing Chinese medicine preparation still can not satisfy clinical and market demand fully, still awaits doing further research to develop even more ideal new Chinese medicine.

The objective of the invention is at this area present situation, by excavate the abundant Chinese medicine resource of motherland provide a kind of prescription science, easy to prepare, curative effect is high and the pure Chinese medicinal preparation that is exclusively used in the treatment woman postpartum disease that human body is had no side effect.

The preparation scheme of medicine of the present invention is that the designer obtains by concentrating one's attention on to sum up to the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs thought of woman postpartum disease and on modern medicine and pharmacology experiment and clinical practice basis according to motherland's traditional medicine.Impairment caused by overstrain, hemorrhage, consume QI and blood when motherland's medical science is thought the many because childbirth of the generation of puerperal disease, so that puerperal " hundred joints are hollow ", weakened defensive QI is taken good care of oneself accidentally slightly, then many pathological changes can take place.The pathomechanism of puerperal disease morbidity, the one, the impairment of chong and ren channels is lost blood and is caused thin fluid injury, and gas is hindered with Tianjin, and then causes QI and blood deficiency; The 2nd, blood-stasis internal-depression, the turbid liquid of surplus blood in puerperal produces the stasis of blood and stagnates or the residual blood-stasis internal-depression that causes of afterbirth.In puerperal all diseases, lochia, stomachache are comparatively common, and its etiology and pathology vessels of the uterus inanition in many because puerperal, cold-evil take advantage of a weak point in opponent's defence into born of the same parents, fight mutually with blood, blood-stasis internal-depression, dash to appoint and lose freely, escape of blood from meridian, so that lochia is dripping with the passing of time more than, said as " tire produces heart method ": " stagnant blood not to the utmost; the difficult peace of then good blood, also descends mutually, and is with the passing of time more than." the stagnant and obstructed person of the blood vessels stasis of blood, then see the lower abdomen pain with tenderness, the lochia amount is few, and the color purple secretly has piece; On the other hand, because the QI and blood consumption is hindered when producing, dash and appoint hollowly, vessels of the uterus loses supports, or blood-deficiency and QI-insufficiency, move unable so that thrombosis, sluggishness and pain, discuss as " women section summary writing paper just) " institute: " lose blood too much, then gas is also empty hungry, and is stagnant and be bitterly." visible blood-stasis internal-depression and QI and blood deficiency be all diseases in puerperal main etiology and pathology of lochia, stomachache especially.For the treatment of puerperal disease, should control in line with dialectical the executing of principle of " do not arrested puerperal, also do not forget " according to the characteristics of multiple deficiency and stasis in antenatal.The Qing Dynasty cures tame Fu Shan "Fu Qingzhu works on obstetric" and advocates reinforcement and elimination in combination, and " SHENGHUATANG that is taken in small doses at short intervals is with the card plus-minus ", " Jing Yue's complete work married woman rule " propose: " puerperal, QI and blood was all gone, sincere many deficiency syndrome.Empty person is so arranged, not empty person is arranged, complete real person is arranged.All this threes, but when with card with the people, debate its deficiency and excess, treat must not with well-established law has big benefit of the general row of sincerity, consequently help heresy ".Though postpartum lochiorrhea, stomachache have the branch of deficiency and excess clinically, most of patients often is a simulataneous insufficiency and excessive, and existing QI and blood deficiency has blood-stasis internal-depression again, and blood stasis does not go, and fresh blood is not given birth to, thereby controls suitable activating blood circulation and supplementing qi, and nourishing blood and hemoslasis is also executed.The etiology and pathology analysis of comprehensive above-described puerperal disease, designer of the present invention chooses that some drug effects are concentrated and easily forms preparation for the raw material of Chinese medicine prescription of absorption of human body.Preparation prescription by the meter ten that comprises Herba Leonuri, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Radix Ginseng Rubra, the Radix Astragali, Colla Corii Asini, Rhizoma Zingiberis Preparatum, Rhizoma Cyperi (processed with vinegar), Fructus Amomi, Radix Glycyrrhizae simply medicine form, full side sincerely keeps the pathogenesis of QI and blood deficiency, blood-stasis internal-depression, with activating blood circulation and supplementing qi, nourishing blood and hemoslasis legislation, aspect the treatment of puerperal disease, have fabulous effect, thereby significantly reducing or eliminate of the threat of this disease perinatal health.

Each raw material components and the proportioning value that constitute medicine of the present invention are: 18～28 unit of weights of Herba Leonuri, 8～16 unit of weights of Radix Angelicae Sinensis, 6～16 unit of weights of Semen Persicae, 3～9 unit of weights of Rhizoma Chuanxiong, 3～9 unit of weights of Radix Ginseng Rubra, 16～24 unit of weights of the Radix Astragali, 6～16 unit of weights of Colla Corii Asini, 3～9 unit of weights of Rhizoma Zingiberis Preparatum, 6～16 unit of weights of Rhizoma Cyperi (processed with vinegar), 3～9 unit of weights of Fructus Amomi, 3～8 unit of weights of Radix Glycyrrhizae.

The preparation of making according to above-mentioned raw materials has demonstrated fully the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle of motherland's traditional medicine about " radicallying reform ", " strengthening vital QI to eliminate pathogenic factors ".Herba Leonuri hardship, suffering in the side, be slightly cold, return liver, pericardium channel, have the merit of promoting blood flow to regulate menstruation, promoting tissue regeneration by removing blood stasis, be married woman's multiparity key medicine." book on Chinese herbal medicine converge with speech " opinion is said: " Herba Leonuri, promoting the circulation of blood is nourished blood, and promoting the circulation of blood and do not hinder fresh blood is nourished blood and the blood stasis that do not stagnate, and really is the panacea of blood man." we use it, focus on blood circulation promoting and blood stasis dispelling, bring into play main therapeutical effect at postpartum lochiorrhea, stomachache due to the blood stasis, so with the Herba Leonuri monarch drug in the side of being.Modern pharmacological research shows that also the contained leonurine of Herba Leonuri, stachydrine have excitation to multiple animal uterus, can be significantly to antiplatelet aggregation and thrombosis, and the enhancing body cellular immune function.Radix Angelicae Sinensis is sweet, hot, warm, returns liver, the heart, spleen channel, has nourshing blood and promoting blood circulation, promoting tissue regeneration by removing blood stasis and effect of relaxing bowel, to blood deficiency, that the syndrome of blood stasis marquis is is suitable; Semen Persicae hardship, sweet, flat, GUIXIN, liver, large intestine channel have blood circulation promoting and blood stasis dispelling, effect of relaxing bowel, and being used for women's blood stasis in puerperal has and push away the old new merit that causes; Rhizoma Chuanxiong suffering, temperature are returned liver, gallbladder, pericardium channel, and the blood-activating and qi-promoting effect is arranged, and arrogate to oneself the gas in the treating blood disorders, and be particularly suitable to the puerperal abdonimal pain due to the stagnation of QI and blood.More than three flavors, Chinese Angelica blood replonishing is invigorated blood circulation, Semen Persicae blood circulation promoting and blood stasis dispelling, Rhizoma Chuanxiong blood-activating and qi-promoting, three's mutual reinforcement between is a usefulness, auxiliary monarch drug to be strengthening the power of its blood circulation promoting and blood stasis dispelling, doublely controls blood deficiency, syndrome of stagnation of QI marquis, but and loosening bowel to relieve constipation, so it is ministerial drug in square altogether.Radix Ginseng Rubra strongly invigorating primordial QI, invigorating the spleen to benefit the lung, Radix Astragali invigorating QI to consolidate the body surface resistance, both phases 5 are controlled the deficient of yang-energy altogether; The Colla Corii Asini nourishing the blood and yin is held concurrently with hemostasis, but losing of nourishing YIN blood is empty; Puerperal how empty much cold, Rhizoma Zingiberis Preparatum warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding are benefited the product tissue regeneration promoting of gas nourishing blood and hemoslasis, the product blood stasis dispelling that assistant is invigorated blood circulation; The Rhizoma Cyperi promoting QI circulation for relieving depression, menstruction regulating and pain relieving is received the merit of promoting flow of QI and blood pain relieving; The Fructus Amomi appetizing of being amusing, the assistant system is grown the fraud that the product of being bored with, invigorating blood circulation hinder the damage of the spleen stomach.Last Six-element and monarch, ministerial drug mutually 5, QI invigorating, circulation of qi promoting are invigorated blood circulation to help, and the benefiting QI and nourishing blood hemostasis is deficient to control, and its fraud that hinders spleen, injures one's stomach of the system of holding concurrently is adjuvant drug in the side altogether.Radix Glycyrrhizae invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription are for Fang Zhongzuo makes it to imitate.More than all medicines compatible, logical mend in conjunction with, imitate Bo Lihong, play the effect of activating blood circulation and supplementing qi, nourishing blood and hemoslasis altogether, be applicable to treatment of conditions such as lochia due to QI and blood deficiency, the blood-stasis internal-depression, stomachache.

A kind of concrete granule goods of medicine of the present invention can obtain by following preparation process: the red ginseng powder in the group component is broken into coarse powder, add 50% ethanol triplication, heating and refluxing extraction 2 times, each 1 hour, merge extractive liquid,, decompression recycling ethanol also is condensed into the clear paste of relative density 1.35～1.40 (60 ℃); The Radix Astragali in the group component is decocted with water three times, and each 10 times of water gagings decocted 1 hour, and collecting decoction filters, and filtrate decompression is condensed into the clear paste of relative density 1.35～1.40 (60 ℃); Rhizoma Chuanxiong, Rhizoma Zingiberis Preparatum, Fructus Amomi three flavor raw materials in the group component were added 2 times of water gagings immersions after 4 hours, extract volatile oil with steam distillation, standby, water liquid device is in addition collected; Herba Leonuri in the group component, Semen Persicae, Radix Angelicae Sinensis, Rhizoma Cyperi (processed with vinegar), Radix Glycyrrhizae five tastes raw material are decocted with water 3 times, for the first time 10 times of water gagings, 8 times of water gagings for the second time, 6 times of water gagings for the third time, each 1 hour, collecting decoction, filter, filtrate decompression is concentrated into medical material: volume is 1: 1 o'clock, adds Colla Corii Asini and dissolves; In dissolving liquid, add Radix Ginseng Rubra and Radix Astragali clear paste, and add the ratio mixing of two portions of Icing Sugar and a dextrin, add an amount of ethanol and make granule in a clear paste, drying under reduced pressure (under 60 ℃), granulate adds volatile oil.Moistening 2 hours gets product.

In the development process of the present invention, be the curative effect of this medicine of objective evaluation to puerperal disease, the people's isolated uterine of getting when designer and units concerned once adopted different animals model and cesarean has been observed this pharmaceutical preparation function of promoting blood circulation to disperse blood clots, tonifying blood and arresting bleeding effect, the influence to the uterine smooth muscle systolic and diastolic function, anti-inflammatory and analgesic effect respectively and to Immune Effects.The result shows, this pharmaceutical preparation:

(1), blood stasis due to qi deficiency rat whole blood viscosity due to the swimming strain in continuous 14 days, plasma viscosity, reduced viscosity and platelet adhesion rate are reduced, and packed cell volume, erythrocyte sedimentation rate and fibrinogen content are not seen obvious influence;

(2), can make normal rat mesometrium blood capillary velocity of blood flow and have the hemocyte capillary vessel number that flows to increase, the blood capillary caliber only slightly increases, and the docking back bleeding time is shortened;

(3), can make the low ferrum feedstuff of feeding add due to the blood-letting that content of hemoglobin, RBC number and serum ferritin content increase in the iron deficiency anemia rat peripheral blood, and platelet count and body weight change are not seen obvious influence;

(4), can make content of hemoglobin in the hemorrhagic anemia mice peripheral blood, RBC number and platelet count increase anoxia time lengthening under the anti-normal pressure;

(5), the deficiency of vital energy mice body weight of growing up due to can making hungry 8 days, spleen body increase than swimming time in, periphery blood T lymphocyte percentage rate and the 10 ℃ of cold water, docking bleeding time and the shortening of capillary glass-tube clotting time that method is surveyed, and to the thymus body than not seeing obvious influence;

(6), can make that disorders of hemostasis clotting time of mice (test tube method) all shortens due to normal rabbits clotting time (multiple calcium method) and the intravenous injection heparin;

(7), rat in puerperal people's isolated uterine contractive amplitude of getting, frequency and vigor when body uterus and cesarean are increased;

(8), can make that rat paw inflammatory swelling degree and the swollen weight of rat granuloma all alleviate due to dimethylbenzene induced mice ear inflammatory swelling degree, the Ovum Gallus domesticus album;

(9), lumbar injection spirit of vinegar induced mice writhing response is alleviated, and 55 ℃ of thermostimulation induced mice pain reaction are not seen obvious influence;

(10), can make Turnover of Mouse Peritoneal Macrophages engulf the chicken red blood cell phagocytic index and phagocytic percentage all increases.

Claims

1, a kind of Chinese medicine that is used for the treatment of woman postpartum disease is characterized in that each raw material components and the proportioning value that constitute this medicine are: 18～28 unit of weights of Herba Leonuri, 8～16 unit of weights of Radix Angelicae Sinensis, 6～16 unit of weights of Semen Persicae, 3～9 unit of weights of Rhizoma Chuanxiong, 3～9 unit of weights of Radix Ginseng Rubra, 16～24 unit of weights of the Radix Astragali, 6～16 unit of weights of Colla Corii Asini, 3～9 unit of weights of Rhizoma Zingiberis Preparatum, 6～16 unit of weights of Rhizoma Cyperi (processed with vinegar), 3～9 unit of weights of Fructus Amomi, 3～8 unit of weights of Radix Glycyrrhizae.

2, be exclusively used in the method for preparing the described Chinese medicine granules of claim 1, it is characterized in that the red ginseng powder in the group component is broken into coarse powder, add 50% ethanol triplication, heating and refluxing extraction 2 times, each 1 hour, merge extractive liquid,, decompression recycling ethanol also is condensed into the clear paste of relative density 1.35～1.40 (60 ℃); The Radix Astragali in the group component is decocted with water three times, and each 10 times of water gagings decocted 1 hour, and collecting decoction filters, and filtrate decompression is condensed into the clear paste of relative density 1.35～1.40 (60 ℃); Rhizoma Chuanxiong, Rhizoma Zingiberis Preparatum, Fructus Amomi three flavor raw materials in the group component were added 2 times of water gagings immersions after 4 hours, extract volatile oil with steam distillation, standby, water liquid device is in addition collected; Herba Leonuri in the group component, Semen Persicae, Radix Angelicae Sinensis, Rhizoma Cyperi (processed with vinegar), Radix Glycyrrhizae five tastes raw material are decocted with water 3 times, for the first time 10 times of water gagings, 8 times of water gagings for the second time, 6 times of water gagings for the third time, each 1 hour, collecting decoction, filter, filtrate decompression is concentrated into medical material: volume is 1: 1 o'clock, adds Colla Corii Asini and dissolves; In dissolving liquid, add Radix Ginseng Rubra and Radix Astragali clear paste, and add the ratio mixing of two portions of Icing Sugar and a dextrin, add an amount of ethanol and make granule in a clear paste, drying under reduced pressure (under 60 ℃), granulate adds volatile oil.Moistening 2 hours gets product.