CN101537095B - Traditional Chinese medicine composition used for gynae regulating the menstrual function - Google Patents
Traditional Chinese medicine composition used for gynae regulating the menstrual function Download PDFInfo
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- CN101537095B CN101537095B CN 200910083020 CN200910083020A CN101537095B CN 101537095 B CN101537095 B CN 101537095B CN 200910083020 CN200910083020 CN 200910083020 CN 200910083020 A CN200910083020 A CN 200910083020A CN 101537095 B CN101537095 B CN 101537095B
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Abstract
The invention relates to a traditional Chinese medicine composition used for gynae regulating the menstrual function, which is made of raw drugs according to the parts by weight: 280-500 parts of motherwort, 280-500 parts of nutgrass galingale rhizome (made by vinegar), 280-500 parts of salvia miltiorrhiza, 50-150 parts of panax pseudoginseng, 100-230 parts of rhizoma corydalis (made by vinegar), 50-150 parts of angelica dahurica and 50-150 parts of liquorice. The medicine composition has the functions of regulating the menstrual function, promoting blood circulation, soothing stagnation of qi due to depression of the liver, promoting the circulation of qi and relieving pain, and can be used for treating symptoms such as menstrual disorder, dysmenorrheal, swollen breast and the like caused by stagnation of qi due to depression of the liver.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition with regulating menstruation, hemostasis, promoting the circulation of QI to relieve pain, said composition is made up of Herba Leonuri, Rhizoma Cyperi, Radix Salviae Miltiorrhizae, Radix Notoginseng, Rhizoma Corydalis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, belongs to technical field of Chinese medicines.
Background technology
Menoxenia is clinical common gynaecopathia.The cause of disease that causes menoxenia is many-sided, but main the diseases caused by exogenous pathogenic factor six climate exopathogens is arranged, internal damage by the excessive seven emotions, and the factors such as change of diet, daily life, environment.Its mechanism and liver,spleen,kidney and function such as dash to appoint not normal, the negative and positive of qi and blood imbalance is relevant, also is related with the physiological characteristics of women " insufficiency of blood gas is many ".The traditional Chinese medical science thinks that menstruation and liver,spleen,kidney are in close relations, and kidney qi is vigorous, and the liver spleen is in harmonious proportion, and contains towards conception vessel, and then menstruation is descended on time.Preceeded menorrhea, or the excess of YANG of factor body, surfeit is pungent, helps heat fostering fire; Or feelings will is irritable or depressed, pathogenic fire derived from stagnation of liver-QI, and heat is disturbed the sea of blood; Or prolonged illness is thanks to cloudy, and the deficiency-heat disturbance is dashed and appointed; Or eating and drinking without temperance, overstrain, worry impairing spleen, insufficiency of the spleen and have under one's command and have no right.Delayed menstrual cycle, or because of the diseases caused by exogenous pathogenic factor cold-evil, the cold coagulation blood vessels; Or the prolonged illness impairment of YANG, fortune blood is unable; Or weakness due to chronic disease, deficiency of YIN-blood, or the improper diet and overtiredness impairment of the spleen, making source deficiency, and cause delayed menstrual cycle.Irregular menstrual period, or because of depressed emotion, the too late then later stage of catharsis, stagnated QI transforming into fire, disturbance is dashed and is appointed then in advance; Or because of a little less than the natural endowment element, severe disease prolonged illness makes deficiency of kidney-QI, and promoting the circulation of blood is unable, or asthenia of essence and blood, and sea of blood inanition is the later stage then, if deficiency of kidney-YIN is disturbed in the asthenic fire then in advance.
Usually will pass through menstrual period, wedding day, pregnancy period, puerperal and five bigger cycles of physiological change of climacteric women's all one's life, the variation of each physiological period easily causes the generation of all kinds of gynaecopathias.The sickness rate of China's gynaecopathia is quite high, Wang Linhong, Zhao Gengli show that in the Epidemiological study result in 15 provinces in the whole nation, 50 cities of municipality directly under the Central Government (district) the married women's common gynecological disease of China city women prevalence is followed successively by reproductive tract infection 42.9%, menoxenia 34.5% (not menopause person) and dysmenorrhea 15.5% (not menopause person), pelvic swelling thing 3.9%, uterine prolapse/vaginal wall bulging 1.1% in proper order.Wherein in the pelvic swelling thing based on hysteromyoma (3.4%), prevalence is 6.8% in the 41-50 year age group, wherein have 48.4% people occur in＞51 years old group in.From EPDML data as can be seen, be that gynecological's Patients with Blood Stasis Syndrome number of representative is compared gynecological inflammation and menoxenia, dysmenorrhea patient's number is much smaller with hysteromyoma and ovarian cyst.Survey data shows that hysteromyoma and ovarian cyst patient account for 4.3% in married woman's gynaecopathia, and the reproductive tract infection women is about 41.7%, menoxenia, dysmenorrhea patient are about 48.5%.
Herba Leonuri is the fresh or dry aerial parts of labiate LeonurusJaponicus Houtt., is traditional Chinese crude drug.The successive dynasties book on Chinese herbal medicine is all on the books, and bright product seedling in spring phase to first summer flower is tapped in earlier stage, does not tap when the luxuriant flower of dry product stem and leaf in summer is opened or just opened, and dries or cutting is dried.Herba Leonuri hardship, suffering, be slightly cold, return liver, pericardium channel, invigorate blood circulation, effect such as regulating menstruation, promoting tissue regeneration by removing blood stasis, inducing diuresis to remove edema.Cure mainly menoxenia, dysmenorrhea, amenorrhea, lochia is more than, metrorrhagia difficult labour, diseases such as postpartum stagnation have the title of " blood man panacea ", " multiparity good medicine ".
Rhizoma Cyperi is the dry rhizome of sedge dried tuber Cyperus rotundus L., acrid in the mouth, little hardship, little sweet, and property is flat.Effect with soothing the liver circulation of qi promoting, menstruction regulating and pain relieving.Rhizoma Cyperi is used in Amino-Cerv extensively, and the beginning is stated from " Mingyi Bielu ", classifies middle product as.The Tang Materia Medica beginning claims Rhizoma Cyperi.Compendium of Material Medica is listed careless portion fragrant grass class in, name " dried tuber Rhizoma Cyperi ".Compendium of Material Medica is referred to as " Directorate-General DG of disorder of QI, the chief commander of women section ".
The salvia Radix Salviae Miltiorrhizae is herbaceos perennial, and applicating history is long in China, and effect is very wide.Traditional medicine thinks that Radix Salviae Miltiorrhizae is walked blood system, promoting blood circulation, and merit is arrogated to oneself blood circulation promoting and blood stasis dispelling." the sensible opinion of married woman " record: " Radix Salviae Miltiorrhizae simply, merit is with four things ".Li Shizhen (1518-1593 A.D.) claims also that in Compendium of Material Medica Radix Salviae Miltiorrhizae has the effect of SIWU TANG.The Radix Salviae Miltiorrhizae main product in Sichuan, ground such as Shanxi, Hebei, Jiangsu, Anhui, medicinal part is got root and rhizome portion, with thick, the interior atropurpureus of bar and Flos Chrysanthemi shape white point person is arranged for good, its cold nature, bitter in the mouth, the popular feeling, pericardium channel and Liver Channel.The effect that state-promulgated pharmacopoeia (version in 2005) is concluded Radix Salviae Miltiorrhizae is that " relieving restlessness clears away heart-fire for stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow.Be used for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swell and ache, dysphoria and insomnia, hepatosplenomegaly, angina pectoris.”
Radix Notoginseng is the tuber of araliaceae ginseng plant Radix Notoginseng (Panax notoginseng F.H.chen), ground such as main product Yunnan, Guangxi, Sichuan, mostly be cultivation, another name Radix Notoginseng, Radix Notoginseng etc., sweet in the mouth, little hardship, warm in nature, return liver, stomach, the heart, small intestine meridian, have effects such as hemostasis, dissipating blood stasis, reducing swelling and alleviating pain, cure mainly spitting of blood, epistaxis, traumatic hemorrhage, traumatic injury etc.Its Main Ingredients and Appearance has active ingredients such as dencichine (Radix Notoginseng propylhomoserin), Radix Notoginseng total arasaponins (PNS), flavone, volatile oil, aminoacid, saccharide, and modern pharmacological research: it has effects such as hemostasis, protecting myocardial cell, protection cerebral tissue, blood fat reducing, antithrombotic, enhancing immunity, antiinflammatory, fibrosis, antitumor, elimination oxygen-derived free radicals, antioxidation.Effect to blood system: anastalsis." book on Chinese herbal medicine is newly organized " goes up and says: " Radix Notoginseng stops blooding refreshing medicine also ".The hemostasis effective ingredient is dencichine (Radix Notoginseng propylhomoserin), is a kind of special acid that separates from Radix Notoginseng.Can shorten the clotting time of mice, and platelet counts is obviously increased; Electron microscopic observation is found: the Radix Notoginseng injection can make the stretching, extension of platelet generation pseudopodium, gathering, modification, take off the granule reaction, these Ultrastructural changes are similar to thrombin Platelet Ultrastructure are changed, can make platelet discharge styptic activity materials such as ADP, antihemophilic factor II and ca so infer Radix Notoginseng, finally show as the effect of coagulant blood.
The hot temperature of loosing of Rhizoma Corydalis is logical. can invigorate blood circulation and can circulation of qi promoting, the gas promoting the circulation of blood is lived, general rule not bitterly, so always as the pain relieving key medicine.Li Shizhen (1518-1593 A.D.)＜Compendium of Materia Medica) carries this product and " specially control all over the body all pains up and down ".The strongest with the tetrahydropalmatine analgesic activity in the main component of Rhizoma Corydalis, persistence, chronic dull pain there are splendid analgesic effect.Pain is the important symptom of blood stasis, and Rhizoma Corydalis energy blood-activating analgetic improves the organ blood supply, can eliminate the pain of alleviating the ischemia organ.It is particularly evident that Rhizoma Corydalis is extremely made the back analgesic effect.Be used for the treatment of headache, menstrual pain and gastrointestinal tract, liver, gallbladder pain, the general antipyretic analgesic of its analgesic activity is strong.This product is ground into powder and is swallowed and can prove effective, and modern makes Chinese patent medicine such as YUANHU ZHITONG PIAN more, have regulate the flow of vital energy, the promoting blood circulation and stopping pain effect.Be usually used in abdominal pain during menstruation, stomachache, hypochondriac pain, headache.
The Radix Angelicae Dahuricae is the dry root of the samphire Radix Angelicae Dahuricae, and because the primary root bar is the root of Dahurian angelica, color is white, so the name Radix Angelicae Dahuricae.The Radix Angelicae Dahuricae is used as medicine and begins to see " herbal classic ", classifies middle product as.It is warm in nature, gas fragrance, and acrid in the mouth, little hardship have effects such as diffusing wind dehumidifying, understand things pain-stopping, detumescence and apocenosis, clinically are mainly used in treating headache due to common cold, supraorbital bone pain, nasal obstruction, different deep pool, toothache, leucorrhea skin infection card such as swell and ache.
Radix Glycyrrhizae is pulse family Glycyrrhiza (Glycgrrhiza) plant, and its root and rhizome is conventional Chinese medicine.The flat sweet in the mouth of property: GUIXIN, lung, spleen, stomach warp.Main effect: QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.
Summary of the invention
The object of the present invention is to provide a kind of gynecological's regulating menstruation medicine with effect of regulating menstruation and activating blood, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, this active constituents of medicine is made by following bulk drugs: Herba Leonuri 280-500 part, Rhizoma Cyperi 280-500 part, Radix Salviae Miltiorrhizae 280-500 part, Radix Notoginseng 50-150 part, Rhizoma Corydalis 100-230 part, Radix Angelicae Dahuricae 50-150 part, Radix Glycyrrhizae 50-150 part.
Preferably, the weight ratio of active raw materials medicine of the present invention is: Herba Leonuri 300-400 part, Rhizoma Cyperi 300-400 part, Radix Salviae Miltiorrhizae 300-400 part, Radix Notoginseng 75-125 part, Rhizoma Corydalis 140-200 part, Radix Angelicae Dahuricae 75-125 part, Radix Glycyrrhizae 75-125 part.
More preferably, the weight ratio of active raw materials medicine of the present invention is: 312 parts of Herba Leonuris, 312 parts of Rhizoma Cyperis, 312 parts of Radix Salviae Miltiorrhizaes, 100 parts of Radix Notoginseng, 178 parts of Rhizoma Corydalis, 89 parts of the Radixs Angelicae Dahuricae, 100 parts in Radix Glycyrrhizae.
Among the present invention, used Rhizoma Cyperi is preferably Rhizoma Cyperi (processed with vinegar), and used Rhizoma Corydalis is preferably Rhizoma Corydalis (processed with vinegar).
When preparing active component of the present invention, can prepare in the following way:
(1) get Rhizoma Cyperi, the Radix Angelicae Dahuricae of recipe quantity, pulverize, extract wherein volatile oil with steam distillation, collect oil content, standby;
(2) other medical material in Rhizoma Cyperi, Radix Angelicae Dahuricae medicinal residues and the prescription mixes, is that the ethanol water of 0-40% extracts 1-3 hour at every turn 1-3 time to contain ethanol, filter, merging filtrate, filtrate decompression is concentrated into rare paste, adding ethanol makes medicinal liquid contain alcohol amount to be 50%-70%, stir, room temperature left standstill 12-24 hour, filtration or centrifugal, get filtrate or supernatant, with filtrate or supernatant concentrating under reduced pressure, drying is ground into powder namely.
Preferably, the preparation method of active component of the present invention can also for:
(1) get Rhizoma Cyperi, the Radix Angelicae Dahuricae of recipe quantity, pulverize, extract wherein volatile oil with steam distillation, collect oil content, standby;
(2) other medical material in Rhizoma Cyperi, Radix Angelicae Dahuricae medicinal residues and the prescription mixes, is that the ethanol water of 20%-40% extracts 2-3 hour at every turn 3 times to contain ethanol, filter, merging filtrate, filtrate decompression is concentrated into rare paste, adding ethanol, to make medicinal liquid contain alcohol amount be 60%, stir, room temperature left standstill 12 hours, filtration or centrifugal, get filtrate or supernatant, with filtrate or supernatant concentrating under reduced pressure, drying is ground into powder namely.
The preparation of active component of the present invention can also realize in the following way: take by weighing the crude drug of recipe quantity, be ground into coarse powder, merge, be that the ethanol water of 0-40% extracts 1-3 time to contain ethanol, each 1-3 hour, filtration, merging filtrate, filtrate decompression are concentrated into rare paste, add ethanol and make medicinal liquid contain alcohol amount to be 50%-70%, stir, room temperature left standstill 12-24 hour, filtration or centrifugal, get filtrate or supernatant, with filtrate or supernatant concentrating under reduced pressure, drying is ground into powder namely
Among the present invention, in preparation during preparation, the volatile oil of gained sprays in the medicated powder after can directly being dissolved in the middle of the ethanol, also can be earlier with the volatile oil beta-cyclodextrin inclusion compound, and mixed mutually with medicated powder again.
Among the present invention, the pharmaceutical dosage form of compositions is any in tablet, capsule, granule, pill, oral liquid, suspension or the emulsion, specifically makes which kind of dosage form, can take or easy to carryly decides according to clinical.
Tablet of the present invention can be any one in common plain sheet, coated tablet, effervescent tablet, dispersible tablet, chewable tablet, the buccal tablet, and wherein coated tablet can be sugar coating, enteric coating, gastric solubleness clothing.
Among the present invention, except active medical material, can also contain acceptable excipient in the pharmacy, one or more in the middle of flavoring agent, dispersant, binding agent, thickening agent, lubricant, diluent, the antiseptic.
Prescription of the present invention is based on Herba Leonuri granule and YUANHU ZHITONG PIAN two sides, and the Herba Leonuri promoting blood circulation to restore menstrual flow adds the Rhizoma Cyperi circulation of qi promoting, and dispersing the stagnated live-QI to relieve the stagnation of QI is aided with Radix Salviae Miltiorrhizae, promoting blood circulation and cooling blood, and stasis-dispelling and pain-killing, the pseudo-ginseng blood-circulation-invigovating pain relieving, Radix Glycyrrhizae is to relax the property of medicine.Focus on diseases such as menoxenia due to the treatment stagnation of QI due to depression of the liver blood stasis, dysmenorrhea, distending pain of the breast.
The pharmacology pharmacodynamic test
Pharmacology embodiment of the present invention serves as test active component object of study with the activity extract of preparation embodiment 4 gained.
One, compound recipe of the present invention is to the influence at the body uterine contraction activity
50 Wistar rats are divided into following 4 groups at random: the basic, normal, high dosage group of extract of the present invention (1.8g crude drug/kg, 3.5g crude drug/kg, 7g crude drug/kg), blank group (giving the distilled water of equivalent), 10 every group.The indoor placement of each treated animal 7 days, first with 10% chloral hydrate 3mL/kg intraperitoneal anesthesia rat in the 8th day, open the abdominal cavity, find out the uterus, go out choosing at a side cornua uteri and clamp apart from the about 0.5cm of vagina end place frog heart clip, be connected with the muscular tension transducer, treat that easypro contracting the in uterus stablize the metaduodenum drug administration by injection, observe uterus curvilinear motion in the 60min, contrast contraction frequency and amplitude size.The results are shown in following table:
Extract of the present invention to rat at the influence of body uterine contraction activity (x ± s)
Each administration group is compared with matched group, all can obviously accelerate rat at the body frequency of uterine contraction and be increased in body uterine contraction amplitude, obvious difference (P＜0.05).
Two, compound recipe of the present invention causes the influence of the writhing response that causes bitterly to glacial acetic acid
40 mices are divided into 4 groups at random, are respectively the basic, normal, high dosage group of extract of the present invention (3.5g crude drug/kg, 7g crude drug/kg, 14g crude drug/kg), blank group (giving the distilled water of equivalent), 10 every group.Each treated animal continuous irrigation stomach 7 days, in the 7th day of administration, last was irritated stomach after 1 hour, and the glacial acetic acid liquid 0.4mL/ of each Mus lumbar injection 0.6% is only.Pick up counting behind the 5min, observe the number of times of each treated animal generation writhing response in the 15min, calculate the writhing response suppression ratio.Writhing response suppression ratio=(blank group mouse writhing number of times-administration group mouse writhing number of times)/blank group mouse writhing number of times * 100%.The results are shown in following table
Medicine of the present invention causes the influence (x ± s) of pain mouse writhing number of times and writhing response suppression ratio to glacial acetic acid
Medicine high dose group of the present invention is turned round the body number of times and is compared obvious reduction with the blank group, the writhing response suppression ratio is 57.9%, difference has statistical significance (P＜0.05), shows that drug extract of the present invention causes the pain mouse writhing to glacial acetic acid and has obvious inhibitory action, and is certain dose-effect relationship.
Three, medicine of the present invention is to the influence of hemorheology of rat index
Get 50 of body weight 220-250g female rats, be divided into 5 groups at random: blank group, model group, the present invention is big, in, small dose group, except the blank group, all the other 4 groups all continuous 7 days the injection diethylstilbestrol (manually cause animal be in just as rutting period, and can improve uterine smooth muscle to the sensitivity of animal), every day 1 (first day 0.4mg/100g, later on every day 0.2mg/100g), begin successive administration after 7 days, one day 2 times, continuous 4 days, administration in the 4th day pneumoretroperitoneum injection in 40 minutes oxytocin 2U/ only, get blood with ether inhalation anesthesia from carotid artery after 2 hours, with TH-18 fully automatic blood rheology analysis system measurement hemorheology index, result such as following table
The present composition is to the influence of hemorheology of rat index (n=10, x ± s)
Experimental study is the result show, medicine continuous irrigation stomach of the present invention 4 days, whole blood viscosity, whole blood reduced viscosity, erythrocyte rigidity index, the blood viscous that can significantly reduce under the high, medium and low shear rate of rat all descend, blood fluidity is good, and blood flow is unobstructed, reflects to have the logical vim and vigour of transferring, the function of microcirculation improvement, cause pain, pro-inflammatory cytokine thereby be conducive to eliminate, relaxing smooth muscle has reached aim of alleviating pain.
Specific embodiment
Following examples only are to be not the restriction embodiments of the present invention for example to a kind of of implementation of the present invention, the present invention can be in restricted portion on the drug regimen combination in any, also can make suitable selection according to clinical needs on the dosage form.
Embodiment 1
Take by weighing Rhizoma Cyperi 280g, Radix Angelicae Dahuricae 150g is ground into coarse powder, spends the night with water logging bubble, and wherein volatile oil is extracted with steam distillation in the back, and volatile oil extracts to the greatest extent to the fraction, collects oil content, and is standby;
Medicinal residues after the extraction mix with Herba Leonuri 400g, Radix Salviae Miltiorrhizae 280g, Radix Notoginseng 50g, Rhizoma Corydalis 100g, Radix Glycyrrhizae 50g, the alcohol reflux with 40% 3 times, each 2 hours, filter, filtrate decompression concentrates, the ethanol of back adding 95% in the concentrated solution, transfer alcohol to make medicinal liquid contain the alcohol amount and reach 70%, fully stir evenly, room temperature is placed and is spent the night, centrifugal, get supernatant, supernatant concentrating under reduced pressure, drying, pulverize, get active medicated powder.
The volatile oil that extracts gained is sprayed in the medicated powder, and add microcrystalline Cellulose, magnesium stearate in medicated powder, the ethanol with 70% is adhesive, is pressed into tablet, totally 800, namely.
Embodiment 2
Take by weighing Rhizoma Cyperi 500g, Radix Angelicae Dahuricae 50g is ground into coarse powder, spends the night with water logging bubble, and wherein volatile oil is extracted with steam distillation in the back, and volatile oil extracts to the greatest extent to the fraction, collects oil content, and is standby;
Medicinal residues after the extraction mix with Herba Leonuri 280g, Radix Salviae Miltiorrhizae 350g, Radix Notoginseng 150g, Rhizoma Corydalis 230g, Radix Glycyrrhizae 120g, the alcohol reflux with 20% 3 times, each 3 hours, filter, filtrate decompression concentrates, the ethanol of back adding 95% in the concentrated solution, transfer alcohol to make medicinal liquid contain the alcohol amount and reach 60%, fully stir evenly, room temperature is placed and is spent the night, centrifugal, get supernatant, supernatant concentrating under reduced pressure, drying, pulverize, get active medicated powder.
Oil content is sprayed in the medicated powder equably, and the ethanol with 70% is adhesive, adds appropriate amount of starch, makes granule.
Embodiment 3
Take by weighing Rhizoma Cyperi 280g, Radix Angelicae Dahuricae 150g is ground into coarse powder, spends the night with water logging bubble, and wherein volatile oil is extracted with steam distillation in the back, and volatile oil extracts to the greatest extent to the fraction, collects oil content, and is standby;
Medicinal residues after the extraction mix with Herba Leonuri 280g, Radix Salviae Miltiorrhizae 280g, Radix Notoginseng 150g, Rhizoma Corydalis 230g, Radix Glycyrrhizae 150g, with water boiling and extraction 3 times, and each 3 hours, filter, filtrate decompression concentrates, the ethanol of back adding 95% in the concentrated solution, transfer alcohol to make medicinal liquid contain the alcohol amount and reach 50%, fully stir evenly, room temperature is placed and is spent the night, filter, get filtrate, filtrate decompression concentrates, drying, pulverize, get active medicated powder.
Oil content is sprayed in the medicated powder equably, and add appropriate amount of starch, mix homogeneously in incapsulating, is made capsule.
Embodiment 4
Take by weighing Rhizoma Cyperi 312g, Radix Angelicae Dahuricae 89g is ground into coarse powder, spends the night with water logging bubble, and wherein volatile oil is extracted with steam distillation in the back, and volatile oil extracts to the greatest extent to the fraction, collects oil content, and is standby;
Medicinal residues after the extraction mix with Herba Leonuri 312g, Radix Salviae Miltiorrhizae 312g, Radix Notoginseng 100g, Rhizoma Corydalis 178g, Radix Glycyrrhizae 100g, the alcohol reflux with 30% 3 times, each 1.5 hours, filter, filtrate decompression concentrates, the ethanol of back adding 95% in the concentrated solution, transfer alcohol to make medicinal liquid contain the alcohol amount and reach 60%, fully stir evenly, room temperature is placed and is spent the night, centrifugal, get supernatant, supernatant concentrating under reduced pressure, drying, pulverize, get active medicated powder.
Oil content is sprayed in the medicated powder equably, and add appropriate amount of starch, the ethanol with 60% is adhesive, makes the 1000g granule, pack, every bag of 10g.
Embodiment 5
Take by weighing Herba Leonuri 400g, Rhizoma Cyperi (vinegar system) 400g, Radix Salviae Miltiorrhizae 400g, Radix Notoginseng 100g, Rhizoma Corydalis (vinegar system) 200g, Radix Angelicae Dahuricae 100g, Radix Glycyrrhizae 100g is ground into coarse powder, with water boiling and extraction 3 times, extraction time was respectively 3 hours, and 2 hours, 1 hour, filter, merge three times water boiling and extraction liquid, filtrate decompression concentrates, and concentrated solution adds 95% ethanol, stir, make medicinal liquid contain alcohol amount and reach and be about 60%, room temperature was placed 24 hours, filtered, filtrate decompression concentrates, drying, pulverize active medicated powder.Add appropriate amount of starch in the medicated powder, the ethanol with 75% is adhesive, makes granule, packs every bag of 5g.
Embodiment 6
Take by weighing Herba Leonuri 280g, Rhizoma Cyperi (vinegar system) 280g, Radix Salviae Miltiorrhizae 280g, Radix Notoginseng 50g, Rhizoma Corydalis (vinegar system) 100g, Radix Angelicae Dahuricae 50g, Radix Glycyrrhizae 50g is ground into coarse powder, soak with ethanol with 20% is extracted 3 times, and extraction time was respectively 2 hours, and 1.5 hours, 1.5 hours, filter, merge three times extracting solution, filtrate decompression concentrates, and concentrated solution adds 95% ethanol, stir, make medicinal liquid contain alcohol amount and reach and be about 50%, room temperature was placed 24 hours, filtered, filtrate decompression concentrates, drying, pulverize active medicated powder.Add appropriate amount of starch in the medicated powder, microcrystalline Cellulose, magnesium stearate, the ethanol with 75% is adhesive, is pressed into tablet, every contains extract 0.40g.
Embodiment 7
Take by weighing Herba Leonuri 500g, Rhizoma Cyperi (vinegar system) 500g, Radix Salviae Miltiorrhizae 500g, Radix Notoginseng 150g, Rhizoma Corydalis (vinegar system) 230g, Radix Angelicae Dahuricae 150g, Radix Glycyrrhizae 150g is ground into coarse powder, ethanol percolate extraction with 30%, thin out to the percolate color, merge percolate, concentrating under reduced pressure, concentrated solution add 95% ethanol, stir, make medicinal liquid contain alcohol amount and reach and be about 60%, room temperature was placed 24 hours, filtered, filtrate decompression concentrates, drying, pulverize active medicated powder.Add appropriate amount of starch in the medicated powder, the ethanol with 70% is adhesive, makes granule, pack, every packed 5g.
Claims (9)
1. a Chinese medicine composition that is used for gynecological's regulating menstruation is characterized in that its active component is to be made by the crude drug of following weight ratio: Herba Leonuri 280-500 part, Rhizoma Cyperi (processed with vinegar) 280-500 part, Radix Salviae Miltiorrhizae 280-500 part, Radix Notoginseng 50-150 part, Rhizoma Corydalis (processed with vinegar) 100-230 part, Radix Angelicae Dahuricae 50-150 part, Radix Glycyrrhizae 50-150 part.
2. compositions according to claim 1 is characterized in that described crude drug weight ratio is: Herba Leonuri 300-400 part, Rhizoma Cyperi (processed with vinegar) 300-400 part, Radix Salviae Miltiorrhizae 300-400 part, Radix Notoginseng 75-125 part, Rhizoma Corydalis (processed with vinegar) 140-200 part, Radix Angelicae Dahuricae 75-125 part, Radix Glycyrrhizae 75-125 part.
3. compositions according to claim 1 is characterized in that described crude drug weight ratio is: 312 parts of Herba Leonuris, 312 parts of Rhizoma Cyperi (processed with vinegar), 312 parts of Radix Salviae Miltiorrhizaes, 100 parts of Radix Notoginseng, 178 parts of Rhizoma Corydalis (processed with vinegar), 89 parts of the Radixs Angelicae Dahuricae, 100 parts in Radix Glycyrrhizae.
4. method for preparing the described compositions active component of arbitrary claim among the claim 1-3 is characterized in that making in the following way:
(1) get Rhizoma Cyperi, the Radix Angelicae Dahuricae of recipe quantity, pulverize, extract wherein volatile oil with steam distillation, collect oil content, standby;
(2) other medical material in Rhizoma Cyperi, Radix Angelicae Dahuricae medicinal residues and the prescription mixes, is that the ethanol water of 0-40% extracts 1-3 hour at every turn 1-3 time to contain ethanol, filter, merging filtrate, filtrate decompression is concentrated into rare paste, adding ethanol makes medicinal liquid contain alcohol amount to be 50%-70%, stir, room temperature left standstill 12-24 hour, filtration or centrifugal, get filtrate or supernatant, with filtrate or supernatant concentrating under reduced pressure, drying is ground into powder namely.
5. method for preparing the described compositions active component of arbitrary claim among the claim 1-3, it is characterized in that making in the following way: the crude drug that takes by weighing recipe quantity, be ground into coarse powder, merge, be that the ethanol water of 0-40% extracts 1-3 time to contain ethanol, each 1-3 hour, filtration, merging filtrate, filtrate decompression is concentrated into rare paste, adds ethanol and makes medicinal liquid contain the alcohol amount for 50%-70%, stirs, room temperature left standstill 12-24 hour, filtration or centrifugal is got filtrate or supernatant, with filtrate or supernatant concentrating under reduced pressure, drying is ground into powder namely.
6. according to the described compositions of arbitrary claim among the claim 1-3, it is characterized in that its dosage form is any in tablet, capsule, granule, oral liquid, suspension or the emulsion.
7. according to arbitrary medicine among the claim 1-3, it is characterized in that also having added acceptable excipient in the pharmacy.
8. medicine according to claim 7 is characterized in that described excipient is one or more in the middle of flavoring agent, dispersant, binding agent, thickening agent, lubricant or the diluent.
9. arbitrary compositions has application aspect regulating menstruation, hemostasis, the promoting the circulation of QI to relieve pain medicine in preparation among the claim 1-3.
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| CN 200910083020 CN101537095B (en) | 2009-04-29 | 2009-04-29 | Traditional Chinese medicine composition used for gynae regulating the menstrual function |
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| CN 200910083020 CN101537095B (en) | 2009-04-29 | 2009-04-29 | Traditional Chinese medicine composition used for gynae regulating the menstrual function |
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| CN101537095A CN101537095A (en) | 2009-09-23 |
| CN101537095B true CN101537095B (en) | 2013-08-14 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068583B (en) * | 2010-11-19 | 2011-11-30 | 宋爱民 | Chinese medicinal preparation for treating preceded menstrual cycle due to deficiency of vital energy |
| CN105343412A (en) * | 2015-12-15 | 2016-02-24 | 李国深 | Traditional Chinese medicinal composition for treating dysmenorrhea |
| CN105816618A (en) * | 2016-05-18 | 2016-08-03 | 亳州市永博保健食品有限公司 | Traditional Chinese medicine decoction for treating irregular menstruation |
| CN107496643A (en) * | 2017-09-28 | 2017-12-22 | 苟稳 | A kind of Chinese medicine composition for treating dysmenorrhoea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1078078C (en) * | 1997-12-05 | 2002-01-23 | 蔡利珊 | Traditional Chinese medicinal preparation for curing gynecopathy |
| CN1164317C (en) * | 2002-11-28 | 2004-09-01 | 贵阳德昌祥药业有限公司 | Zaizao Pill for treating woman diseases |
| CN1679913A (en) * | 2005-02-03 | 2005-10-12 | 贵阳德昌祥药业有限公司 | Gynecologic rehabilitation capsules for treating gynecopathy |
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