CN1509742A - Medicinal composition for treating cancer - Google Patents

Abstract

A Chinese medicine in the form of powder, tablet, capsule, particles, or instant particles for treating cancer is prepared from 12 Chinese-medicinal materials including pilose asiabell root, white atractylodes rhizome, oldenlandia, liquorice root, etc. Its advantage is sure curative effect.

Description

The pharmaceutical composition of treatment cancer

(1) technical field under

The present invention relates to treat the pharmaceutical composition of cancer, is exactly the pharmaceutical preparation with the Chinese crude drug preparation specifically.

(2) background technology

Cancer is a class disease very big to human health risk, and its treatment remains a great problem medically.The Chinese and western drugs of the present treatment cancer of using, perhaps cure rate is low, and perhaps side effect is big, all can't make the people satisfied.Chinese medicine characteristics occurred much respectively having in characteristic and advantage that oneself is arranged aspect the treatment cancer, and the Chinese patent medicine of certain curative effect is arranged.But these shortcomings that Chinese patent medicine ubiquity curative effect is lower, onset is slower often need also to use simultaneously with multiple Western medicine.Therefore, the advantage of performance Chinese medicine aspect the treatment cancer, excavation better efficacy, side effect Chinese patent medicine still less are the needs of clinical treatment.

(3) summary of the invention

The object of the present invention is to provide a kind of pharmaceutical preparation with Chinese medicine natural drug combined preparation, its manufacture method is easy, economical, easy to use, and the treatment cancer is had sure effect.

Pharmaceutical composition of the present invention is the medicament of being made by following materials of weight proportions medicine:

30～80 parts of 5～20 parts of Ganoderma Lucidums of 30～100 parts of gun gingers of 30～100 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis

20～50 parts of 10～40 portions of Herba Artemisiae Annuaes of 10～40 portions of Radix Glycyrrhizaes of 10～50 parts of Herba Hedyotidis Diffusaes of Gekko Swinhonis

10～50 parts of 10～50 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 10～30 parts of Carapax Trionycis of 30～100 parts of Periostracum Serpentiss of Rhizoma Paridis

The preferred weight proportion of above component is,

40～60 parts of 5～15 parts of Ganoderma Lucidums of 35～65 parts of gun gingers of 40～70 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis

25～40 parts of 15～30 portions of Herba Artemisiae Annuaes of 10～30 portions of Radix Glycyrrhizaes of 10～35 parts of Herba Hedyotidis Diffusaes of Gekko Swinhonis

10～33 parts of 10～35 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 14～30 parts of Carapax Trionycis of 40～60 parts of Periostracum Serpentiss of Rhizoma Paridis

The weight proportion of above component the best is,

50 parts of 10 parts of Ganoderma Lucidums of 50 parts of gun gingers of 50 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis

30 parts of 20 portions of Herba Artemisiae Annuaes of 25 portions of Radix Glycyrrhizaes of 30 parts of Herba Hedyotidis Diffusaes of Gekko Swinhonis

30 parts of 30 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 20 parts of Carapax Trionycis of 50 parts of Periostracum Serpentiss of Rhizoma Paridis

Use above crude drug, can adopt common process, make said medicament on the pharmaceutics, comprise dosage forms such as powder, tablet, capsule, granular pattern electuary.Its technology point is,

With Radix Codonopsis, Ganoderma Lucidum, keep official, each medicine pulverize separately of Herba Hedyotidis Diffusae, mix after crossing dusting cover;

2. the Rhizoma Atractylodis Macrocephalae, gun ginger, Radix Glycyrrhizae, Herba Artemisiae Annuae, Rhizoma Paridis, Periostracum Serpentis, Carapax Trionycis, each medicine of the Pseudobulbus Bletillae (Rhizoma Bletillae) are merged and add water saturates, decoct 3 times, decocted 30～120 minutes at every turn, merge decoction liquor and filter, shorten clear paste into.

3. add the made medicated powder of step 1 in clear paste, mixing is made granule, and drying is the powder finished product.Powder incapsulated be capsule.Powder further can also be processed into tablet, granular pattern electuary.

Pharmaceutical composition of the present invention is seted forth one's views with " caused by qi and cold stagnation " of the traditional Chinese medical science, is rule and prescription is applicable to multiple malignant tumor such as esophageal carcinoma, gastric cancer, hepatocarcinoma, breast carcinoma, osteosarcoma with " QI invigorating is dispeled cold, Baconic's complement ".One week of medication can take effect, and its pain relief, heating are gone down.2～3 weeks of medication, visible lump reduced.Cure case and generally need treat 8 months, cured in the shortest two months.Cure a routine esophageal carcinoma in 1985, do not have recurrence so far in 17 years.

(4) specific embodiment

The invention will be further described by the following examples.

Embodiment 1 produces powder

Prescription: Radix Codonopsis 500g art 500g gun ginger 100g Ganoderma Lucidum 500g Gekko Swinhonis 300g

Herba Hedyotidis Diffusae 250g Radix Glycyrrhizae 200g Herba Artemisiae Annuae 300g Rhizoma Paridis 500g Periostracum Serpentis 200g

Carapax Trionycis 300g Pseudobulbus Bletillae (Rhizoma Bletillae) 300g

With Radix Codonopsis, Ganoderma Lucidum, keep official, each medicine pulverize separately of Herba Hedyotidis Diffusae, cross 150 mesh sieves, mix homogeneously;

2. the Rhizoma Atractylodis Macrocephalae, gun ginger, Radix Glycyrrhizae, Herba Artemisiae Annuae, Rhizoma Paridis, Periostracum Serpentis, Carapax Trionycis, each medicine of the Pseudobulbus Bletillae (Rhizoma Bletillae) are merged and soak into back decoction 3 times, decocted 30～120 minutes at every turn, merge decoction liquor and filter, be condensed into clear paste.

3. add the made medicated powder of step 1 in clear paste, make granule, drying is ground into powder and is the powder finished product.

The every gram finished product of present embodiment contains the crude drug equivalent and is about 10 grams.Each oral 4～8 grams, every day 4～6 times.

Embodiment 2 produces tablet

Prescription: Radix Codonopsis 750g Rhizoma Atractylodis Macrocephalae 800g gun ginger 140g Ganoderma Lucidum 600g Gekko Swinhonis 200g

Herba Hedyotidis Diffusae 350g Radix Glycyrrhizae 180g Herba Artemisiae Annuae 380g Rhizoma Paridis 285g Periostracum Serpentis 200g

Carapax Trionycis 320g Pseudobulbus Bletillae (Rhizoma Bletillae) 400g

With Radix Codonopsis, Ganoderma Lucidum, keep official, each medicine pulverize separately of Herba Hedyotidis Diffusae, cross 200 mesh sieves, mix homogeneously;

2. the Rhizoma Atractylodis Macrocephalae, gun ginger, Radix Glycyrrhizae, Herba Artemisiae Annuae, Rhizoma Paridis, Periostracum Serpentis, Carapax Trionycis, each medicine of the Pseudobulbus Bletillae (Rhizoma Bletillae) are merged and soak into back decoction 3 times, decocted 30～120 minutes at every turn, merge decoction liquor and filter, be condensed into clear paste.

3. in clear paste, add the made medicated powder of step 1, make granule, drying, compacting is in blocks, and sugar coating promptly gets the tablet finished product.

Present embodiment can be made into about 300 of tablet.Every contains about 14.35 grams of crude drug equivalent.Each oral 4～6 of adult patients, every day 3 times.

Embodiment 3 produces capsule

Prescription: Radix Codonopsis 300g Rhizoma Atractylodis Macrocephalae 600g gun ginger 100g Ganoderma Lucidum 450g Gekko Swinhonis 400g

Herba Hedyotidis Diffusae 400g Radix Glycyrrhizae 100g Herba Artemisiae Annuae 250g Rhizoma Paridis 70g Periostracum Serpentis 130g

Carapax Trionycis 300g splendid achnatherum 200g

With Radix Codonopsis, Ganoderma Lucidum, keep official, each medicine pulverize separately of Herba Hedyotidis Diffusae, cross 150 mesh sieves, mix homogeneously;

2. the Rhizoma Atractylodis Macrocephalae, gun ginger, Radix Glycyrrhizae, Herba Artemisiae Annuae, Rhizoma Paridis, Periostracum Serpentis, Carapax Trionycis, each medicine of the Pseudobulbus Bletillae (Rhizoma Bletillae) are merged and soak into back decoction 3 times, decocted 30～120 minutes at every turn, merge decoction liquor and filter, be condensed into clear paste.

3. in clear paste, add the made medicated powder of step 1, make granule, spray-dried, make fine powder, the adding vegetable oil is mixed the back pelletize thoroughly and is made capsule in fine powder again.

Present embodiment can be made into about 220 of capsule.Every contains about 15 grams of crude drug equivalent.Each oral 3～4 of adult patients, every day 3 times.

Embodiment 4 treatment cancers 188 routine clinical observation on the therapeutic effect

(1) physical data

This is organized in 188 examples, male 61 examples, women 127 examples; Age is from 31～76 years old, average 54.6 years old.Tumor locus: mammary cancer 1 23 examples, esophagus cancer 18 examples, gastric cancer 27 examples, osteoma 2 examples.The course of disease is the shortest 3 months, and is the longest 7 years.

Diagnostic method: all cases all turn out to be squamous cell carcinoma, adenocarcinoma, adeno-squamous carcinoma, the patient of typing cancer not through B ultrasonic, CT, MEPI, X line barium meal, gastroscope, pathological section.Wherein pathological section is diagnosed 20 examples, and B ultrasonic, rectoscope, X line are taken the photograph sheet, alpha-fetoprotein, leukemia blastocyte, esophagoscope, CT etc. and checked diagnosis 168 examples.

All cases are all once with other method treatment, because of Drug therapy of the present invention is accepted in invalid or recurrence.In this group case, person's 20 examples once do not operate; Ceng Zuofang, chemotherapy combined treat three the course of treatment person's 80 examples; Radiation alone or chemotherapy person's three courses of treatment 30 examples, two the course of treatment person's 38 examples, one the course of treatment person's 20 examples.

(2) Therapeutic Method

Press the anticancer powder of embodiment 1 method preparation, each oral 4～8 grams, every day 4～6 times.One month is a course of treatment.Reduce by half after two courses of treatment and take, continue and obeyed for 3～10 courses of treatment.Most cases interval two weeks between the course of treatment is gone and is taken medicine.

(3) therapeutic outcome

(1) symptom and sign improves the effect of aspect: 16 symptom and signs examinations such as symptom and sign improves by spirit, appetite, pain, heating, hemorrhage (have blood in stool, spitting of blood, hematemesis, hematuria), coughs, coughs up phlegm, hydrothorax, ascites, edema, uncomfortable in chest, abdominal distention, nausea,vomiting,diarrhea, jaundice, all have improve more than 2 or 2 be effective.See Table 1.

Table 1 symptom and sign improves effect

Classification	The example number	Effective routine number	Effective percentage
				Breast carcinoma	????123	????123	????100％
Esophageal carcinoma	????18	????18	????100％
				Gastric cancer	????27	????27	????100％
Hepatocarcinoma	????18	????18	????100％
				Osteoma	????2	????1	????50％
Add up to	????188	????187	????99.4％

Table 1 shows that it is 99.4% that pharmaceutical composition of the present invention improves effective percentage to breast carcinoma, esophageal carcinoma, gastric cancer, hepatocarcinoma, osteoma symptom and sign, and osteosarcoma is had only 50%.

(2) analgesia contrast: in therapeutic process, in the effect to the alleviation cancerous pain, use bucinnazine with the 16 routine patients that select at random and do the pain relieving contrast at observation pharmaceutical composition of the present invention.The pain relief degree is pressed CR (alleviating fully), PR (part is alleviated), MR (little effect), NC (stablizing), the evaluation of PC (invalid) Pyatyi.Effectively case is CR+PR+MP, and the result is as follows.

Table 2 a liang group is alleviated cancer pain relatively

Grouping	The pain classification	The example number	????CR	????PR	????MR	????NC
							The treatment group	????I	????3	????3
????II	????7	????6	????1
						????III		????4	????3	????1
????IV	????2	????1			????1
						Matched group		????I	????1	????1
????II	????9	????1	????5	????3
							????III	????4			????2	????2
????IV	????2				????2

The used bucinnazine of matched group is that Tianjin aminoacid company produces lot number: 980527, and 100mg intramuscular injection, 2 times on the 1st.The pain standard adopts 5 grades of pain stage divisions of WHO: 0 grade of no pain; I level mild pain, intermittent pain; II level moderate pain is lasting pain, and influence is had a rest; III level severe pain is for continuing severe pain; The IV level is pain extremely, for continuing severe pain, with perspiration, heart rate quickening, autonomic nervous dysfunction symptom.Two groups of contrasts, treatment group CR13 example, PR2 example, NC1 example, total effective rate 93.8%; Matched group CR2 example, PR5 example, MR5 example, NC4 example, total effective rate 75%.There were significant differences (P＜0.05) for two groups of therapeutic effect, and the treatment group is better than matched group to the cancerous pain analgesic effect.

(3) eliminate the effect that tumor is generated heat: with drug combination preparation of the present invention is the treatment group, contrasts with indometacin group, Dexamethasone group, compound aminophenazone, observes the effect of eliminating the tumor heating, the results are shown in Table 3.

The curative effect that carcinous heat falls in four groups of medicines of table 3 compares

Group		The example number	Thermal effect falls			Total effective rate %
							Produce effects	Effectively	Invalid
			The treatment group		????30					????26	????3	????1	????96.7
Matched group	Indometacin	????30				????4	????10	????16	????46.7
			Dexamethasone	????12	????2					????4	????6	????50.0
	Compound aminophenazone	????8				????0	????1	????7	????12.5

The matched group administrated method: indometacin 250mg, 3 times on the 1st, oral; Dexamethasone 4～12mg adds liquid of glucose 500ml, quiet 1 time on the 1st; Compound aminophenazone 2ml, intramuscular injection, 1 time on the 1st.Two groups of each continuous uses 7 days were a course of treatment, observe the curative effect.

Criterion of therapeutical effect: produce effects: body temperature is normal, and drug withdrawal does not have recurrence heating phenomenon in 7 days; Effectively: body temperature reduces, but fails to return to normal range, can stablize after the drug withdrawal; Invalid: body temperature is failed control, or reduces during medication, the level to the medication of ging up after the drug withdrawal.Fall cancer fever relatively from four groups of medicines of table 3, treatment group total effective rate is 96.7%; In the matched group, indometacin effective percentage 46.7%, dexamethasone effective percentage 50%, compound aminophenazone effective percentage 12.5%.Relatively there were significant differences (P＜0.05) for two groups of effective percentage, and the treatment group is better than indometacin, dexamethasone, compound aminophenazone in reducing the cancer fever treatment.

Body temperature gos up relatively after four groups of drug withdrawals of table 4

Group	Hot routine number falls	The rise time after the drug withdrawal			Drug withdrawal body temperature rise in 7 days rate %
						1～3 day	3～5 days	5～7 days
		The treatment group	??30	??0					??0	??3	????9.9
Indometacin	??30				??8	??2	??3	????42.9
		Dexamethasone	??13	??5					??1	??0	????50.0
Compound aminophenazone	??8				??6	??1	??0	????87.5

Table 4 shows that body temperature gos up relatively after four groups of drug withdrawals, and the treatment group is better than three kinds of medicines of matched group, obvious difference (P＜0.05%).

Pharmaceutical composition of the present invention is not found untoward reaction in therapeutic process.Long-term band tumor existent does not have serious malaise symptoms.

Claims (5)

1, a kind of pharmaceutical composition of the treatment cancer with Chinese medicine natural drug preparation is characterized in that described pharmaceutical composition is the medicament of being made by following raw materials by weight proportions:

30～80 parts of 5～20 parts of Ganoderma Lucidums of 30～100 parts of gun gingers of 30～100 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis

20～50 parts of 10～40 portions of Herba Artemisiae Annuaes of 10～40 portions of Radix Glycyrrhizaes of 10～50 parts of Herba Hedyotidis Diffusaes of Gekko Swinhonis

10～50 parts of 10～50 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 10～30 parts of Carapax Trionycis of 30～100 parts of Periostracum Serpentiss of Rhizoma Paridis

2, the described pharmaceutical composition of claim 1, the weight proportion of raw materials used medicine be,

40～60 parts of 5～15 parts of Ganoderma Lucidums of 35～65 parts of gun gingers of 40～70 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis

25～40 parts of 15～30 portions of Herba Artemisiae Annuaes of 10～30 portions of Radix Glycyrrhizaes of 10～35 parts of Herba Hedyotidis Diffusaes of Gekko Swinhonis

10～33 parts of 10～35 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 14～30 parts of Carapax Trionycis of 40～60 parts of Periostracum Serpentiss of Rhizoma Paridis

3, the described pharmaceutical composition of claim 1, the weight proportion of raw materials used medicine be,

50 parts of 10 parts of Ganoderma Lucidums of 50 parts of gun gingers of 50 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis

30 parts of 20 portions of Herba Artemisiae Annuaes of 25 portions of Radix Glycyrrhizaes of 30 parts of Herba Hedyotidis Diffusaes of Gekko Swinhonis

30 parts of 30 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 20 parts of Carapax Trionycis of 50 parts of Periostracum Serpentiss of Rhizoma Paridis

4, the described pharmaceutical composition of claim 1 is meant and adopts common process to make said any medicament on the pharmaceutics.

5, the described medicament of claim 4 is powder, tablet, capsule, granular pattern, electuary.