CN1745845A - Chinese medicinal composition for treating and inhibiting tumor, its preparation and use - Google Patents
Chinese medicinal composition for treating and inhibiting tumor, its preparation and use Download PDFInfo
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- CN1745845A CN1745845A CN 200510112992 CN200510112992A CN1745845A CN 1745845 A CN1745845 A CN 1745845A CN 200510112992 CN200510112992 CN 200510112992 CN 200510112992 A CN200510112992 A CN 200510112992A CN 1745845 A CN1745845 A CN 1745845A
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Abstract
A Chinese medicine for suppressing and treating cancers, especially the lung cancer, stomach cancer and liver cancer, and decreasing the by-effect of chemicotherapy is prepared from fresh ganoderma and/or its sporophore, oldenlandia, ginger and liquorice root through mixing them with water, beating to become slurry, heating to 50-80 Deg C., stirring while reacting for 4-8 hr, concentrating and shaping.
Description
Technical field
The present invention relates to Chinese medicine pharmaceutical composition of a kind of inhibition and treatment tumor and its production and application.
Background technology
The medicine of various inhibition of selling on the medical market at present, and treatment tumor is more.But effect is not good enough, the medicine of broad spectrum activity suppression therapy tumor is less, moreover price height, effect is not very desirable, the preparation that preparation of pharmaceutical compositions method of the present invention is extracted is to the rehabilitation of postoperative patient and to alleviate the untoward reaction effect of chemicotherapy obvious, particularly obvious to pulmonary carcinoma, gastric cancer, early stage liver cancer treatment effect, up to the present still for seeing the pharmaceutical composition that the present invention treats tumor.
Summary of the invention
The purpose of this invention is to provide a kind of the inhibition and Chinese medicine pharmaceutical composition of treatment tumor and its production and application, overcome that existing inhibition and medicine for treating tumor thing broad spectrum activity are poor, the not enough significant disadvantage of effect.
The Chinese medicine pharmaceutical composition of a kind of treatment and inhibition tumor is by the preparation that comprises that following raw material components is prepared from: fresh sesame and/or fresh sesame sporophore, Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae.
Described raw material components is preferably following parts by weight of component: fresh sesame and/or fresh sesame sporophore 60-80, Herba Hedyotidis Diffusae 20-30, Rhizoma Zingiberis Recens 6-10, Radix Glycyrrhizae 3-6, water are an amount of, as 650-850; When wherein containing the compositions of fresh sesame and fresh sesame sporophore, the ratio of fresh sesame and fresh sesame sporophore is suitable to get final product, and is preferably 1-5: 5-1.
Described pharmaceutical composition raw material components is preferably following parts by weight of component: fresh sesame and/or fresh sesame sporophore 70, Herba Hedyotidis Diffusae 23, Rhizoma Zingiberis Recens 8, Radix Glycyrrhizae 4, water are an amount of, as 750; When wherein containing the compositions of fresh sesame and fresh sesame sporophore, the ratio of fresh sesame and fresh sesame sporophore is preferably 1: 1.
The Chinese medicine pharmaceutical composition of described treatment and inhibition tumor can be made several formulations, is preferably oral liquid.
The present invention also provides a kind of Chinese medicine preparation of drug combination method that suppresses and treat tumor, may further comprise the steps:
(1) fresh sesame and/or fresh sesame sporophore, Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are mixed, add water through being ground into pulpous state;
(2) with said mixture 50-80 ℃ of continuous stirring thermal response 4-8 hour;
(3) the filtered liquid of above-mentioned thermal agitation reactant mixture was added the retort secondary response 2-4 hour;
(4) liquid with above-mentioned secondary response concentrates, and is condensed into the liquid of proportion 1.05-1.2, carries out packing and promptly gets the pharmaceutical composition that suppresses and treat tumor.
The Chinese medicine preparation of drug combination method of described inhibition and treatment tumor, wherein the mixed powder of preferred steps (1) is broken into pulpous state under 60-70 ℃ temperature, is 750: 70: 23 in water, fresh sesame and fresh sesame sporophore, Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae according to weight ratio: 8: 4 proportioning ratio places retort to stir fully mixing; It is with the abundant stirring reaction 4-8 of paste mixture hour under 50-80 ℃ that the thermal agitation of described step (2) mixes.
Described preparation method, preferably step (2) Continuous Heat stirred 6 hours; Described step (3) is filtered stirred reaction mixture and was added the retort secondary response 3 hours.
The present invention also provides the application of the Chinese medicine pharmaceutical composition of a kind of inhibition and treatment tumor at preparation inhibition and medicine for treating tumor object space face.
Fresh sesame and fresh sesame sporophore can improve the human body body immunity comprehensively in the medicine of the present invention, Herba Hedyotidis Diffusae has therapeutical effect to the treatment kinds of tumors, and Rhizoma Zingiberis Recens, Radix Glycyrrhizae have the auxiliary treatment effect to tumor, and Radix Glycyrrhizae is regulated the flavour of a drug effect in addition.
Function cures mainly: medicine of the present invention is to inhibition and treat gastric cancer, pulmonary carcinoma, hepatocarcinoma, have unique curative effect, and postoperative is taken and can effectively be prevented cancer metastasis and recurrence, prolongs life cycle.
The present invention suppresses and treat the medicine oral liquid instructions of taking of tumor: take every day three times, take (20ml) at every turn, 30 days is a course of treatment.
Medicine of the present invention has the following advantages:
1, medicine of the present invention, all adopting the botanical herbs material is raw material, and the oral liquid made of method that soak to extract of utilization thermal response, it is with fresh sesame and fresh sesame sporophore, the active ingredient of Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae medicine, to the rehabilitation of gastric cancer, pulmonary carcinoma, hepatocarcinoma postoperative and the reaction of minimizing chemicotherapy, effect is obvious.Wherein, fresh sesame and fresh sesame sporophore have analgesia, improve immunologic function, and Rhizoma Zingiberis Recens can be detoxified, and Herba Hedyotidis Diffusae, Radix Glycyrrhizae all have the effect of treatment tumor.
2, use medicine of the present invention, chemicotherapy ill symptoms reaction in 6-8 days is alleviated during the chemicotherapy, and after medication course of treatment, effect is obvious.Can effectively stop the recurrence of postoperative cancer metastasis as rehabilitation.
3, pharmaceutical composition of the present invention can effectively suppress and treat tumor, has obtained curative effect preferably through the clinical practice to pulmonary carcinoma over 3 years, and the present invention has no side effect to the patient, has good effect, and medical expense is low, wield advantage.
4, the preparation of medicine of the present invention has curative effect height, characteristics that toxicity is low, can be widely used in antitumor, as digestive tract tumor such as hepatocarcinoma, gastric cancer, esophageal carcinoma and pulmonary carcinoma, breast carcinoma, cervical cancer, lymphatic cancer, oral squamous cell carcinomas etc., especially to alopecia during the tumor patient chemicotherapy, feel sick, inappetence, etc. symptom greatly alleviate or disappear, postoperative is consolidated rehabilitation and is interrupted, and effectively stops the diffusion of tumor and recurrence to have significant effect.
For proving above-mentioned advantage, the embodiment of the invention 1 pharmaceutical composition has carried out following clinical treatment observation, and relevant treatment situation is as follows:
1, patient profile: select hepatocarcinoma, gastric cancer, esophageal carcinoma, pulmonary carcinoma, breast carcinoma, cervical cancer, lymphatic cancer, eight kinds of chemotherapy of tumors patients of oral squamous cell carcinomas and postoperative rehabilitation patient.
2, patient source: hospital outpatient patient.
3, go into the group standard: sex men and women half and half, and the age is not limit; Breast carcinoma, the woman.
4, administrated method: take pharmaceutical composition of the present invention, every day three times, each 20ml is one, and taking 90 is a course of treatment, and be 30 days a course of treatment.
5, efficacy evaluation:
Cure: patient's transference cure.
Produce effects: patient's symptom is obviously improved.
Effectively: patient's doing well,improving.
Invalid: patient's symptom does not have improvement.
6, therapeutic outcome:
| Kinds of Diseases | Case load | Cure | Produce effects | Effectively | Invalid | ||||
| Cure rate | Cure routine number | Obvious effective rate | Produce effects example number | Effective percentage | Effective routine number | Inefficiency | Invalid routine number | ||
| Hepatocarcinoma | 120 | 90％ | 108 | 94.1％ | 113 | 95.8％ | 115 | 4.2％ | 5 |
| Gastric cancer | 100 | 91％ | 91 | 93％ | 93 | 96％ | 96 | 4％ | 4 |
| Esophageal carcinoma | 80 | 90％ | 72 | 92.5％ | 74 | 95％ | 76 | 5％ | 4 |
| Pulmonary carcinoma | 100 | 88％ | 88 | 90％ | 90 | 92％ | 92 | 8％ | 8 |
| Breast carcinoma | 100 | 89％ | 89 | 91％ | 91 | 94％ | 94 | 6％ | 6 |
| Cervical cancer | 80 | 88.8％ | 71 | 90％ | 72 | 93.8％ | 75 | 6.2％ | 5 |
| Lymphatic cancer | 60 | 88.3％ | 53 | 90％ | 54 | 93.3％ | 56 | 6.7％ | 4 |
| Oral squamous cell carcinomas | 80 | 90％ | 72 | 91.2％ | 73 | 95％ | 76 | 5％ | 4 |
Behind the drug administration of the present invention, alopecia during the chemicotherapy, feel sick, inappetence, etc. symptom greatly alleviate or disappear, postoperative is consolidated the rehabilitation interruption, effectively stops the diffusion and the recurrence of tumor.
As, pulmonary carcinoma chemicotherapy 100 routine alopecia, nauseating, inappetence produce effects, postoperative pulmonary carcinoma is taken 2 years 120 examples, and shifting and recurrence all appears in the patient.
Sum up:
Most of patients is taken Western medicine before proving the treatment of this experimental group case by experiment, but the side effect of Western medicine is big, and effect is also not obvious, adopts pharmaceutical composition of the present invention that patients with lung cancer postoperative chemicotherapy and rehabilitation are had remarkable result, and to the nontoxic multiple effect of patient, effect is remarkable.
The specific embodiment
Embodiment 1
A kind of Chinese medicine drug composition oral liquid that suppresses and treat pulmonary carcinoma, (kg) is prepared from by following raw material: fresh sesame and fresh sesame sporophore 70, Herba Hedyotidis Diffusae 23, Rhizoma Zingiberis Recens 8, Radix Glycyrrhizae 4; The ratio of wherein fresh sesame and fresh sesame sporophore is 1: 1.
Preparation method: above-mentioned fresh sesame and fresh sesame sporophore, Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are mixed, and water 750kg is ground into pulpous state; Said mixture was 60 ℃ of continuous stirring thermal responses 6 hours; The filtered liquid of above-mentioned thermal agitation reactant mixture was added the retort secondary response 3 hours; The liquid of above-mentioned secondary response is concentrated, be condensed into the liquid of proportion 1.05-1.2, be distributed into the oral liquid formulations of 20ml, sterilization promptly gets the pharmaceutical composition that suppresses and treat tumor.
Embodiment 2
A kind of Chinese medicine drug composition oral liquid that suppresses and treat pulmonary carcinoma, (kg) is prepared from by following raw material: fresh sesame or fresh sesame sporophore 60, Herba Hedyotidis Diffusae 20, Rhizoma Zingiberis Recens 6, Radix Glycyrrhizae 3.
Preparation method: above-mentioned fresh sesame or fresh sesame sporophore, Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are mixed, and water 650kg is ground into pulpous state; Said mixture was 50 ℃ of continuous stirring thermal responses 4 hours; The filtered liquid of above-mentioned thermal agitation reactant mixture was added the retort secondary response 2 hours; The liquid of above-mentioned secondary response is concentrated, be condensed into the liquid of proportion 1.05-1.2, be distributed into the oral liquid formulations of 20ml, sterilization promptly gets the pharmaceutical composition that suppresses and treat tumor.
Embodiment 3
A kind of Chinese medicine medicament composition capsule agent that suppresses and treat pulmonary carcinoma, (kg) is prepared from by following raw material: fresh sesame and fresh sesame sporophore 80, Herba Hedyotidis Diffusae 30, Rhizoma Zingiberis Recens 10, Radix Glycyrrhizae 6; The ratio of wherein fresh sesame and fresh sesame sporophore is 1: 5.
Preparation method: above-mentioned fresh sesame and fresh sesame sporophore, Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are mixed, and water 850kg is ground into pulpous state; Said mixture was 80 ℃ of continuous stirring thermal responses 8 hours; The filtered liquid of above-mentioned thermal agitation reactant mixture was added the retort secondary response 4 hours; The liquid of above-mentioned secondary response is concentrated, be condensed into the liquid of proportion 1.05-1.2, capsule preparation method thereof is made capsule routinely then, and sterilization promptly gets the pharmaceutical composition that suppresses and treat tumor.
Embodiment 4
A kind of Chinese medicine pharmaceutical composition tablet that suppresses and treat pulmonary carcinoma, (kg) is prepared from by following raw material: fresh sesame and fresh sesame sporophore 70, Herba Hedyotidis Diffusae 23, Rhizoma Zingiberis Recens 8, Radix Glycyrrhizae 4; The ratio of wherein fresh sesame and fresh sesame sporophore is 5: 1.
Preparation method: above-mentioned fresh sesame and fresh sesame sporophore, Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are mixed, and water 750kg is ground into pulpous state; Said mixture was 60 ℃ of continuous stirring thermal responses 6 hours; The filtered liquid of above-mentioned thermal agitation reactant mixture was added the retort secondary response 3 hours; The liquid of above-mentioned secondary response is concentrated, be condensed into the liquid of proportion 1.05-1.2, method for preparing tablet thereof is made tablet routinely then, and sterilization promptly gets the pharmaceutical composition that suppresses and treat tumor.
Embodiment 5
A kind of Chinese medicine drug composition oral liquid that suppresses and treat pulmonary carcinoma, (kg) is prepared from by following raw material: fresh sesame and fresh sesame sporophore 60, Herba Hedyotidis Diffusae 20, Rhizoma Zingiberis Recens 6, Radix Glycyrrhizae 3; The ratio of wherein fresh sesame and fresh sesame sporophore is 2:3.
Preparation method is with embodiment 2.
Embodiment 6
The Chinese medicine pharmaceutical composition of one of embodiment 1-5 is in the application of preparation inhibition and medicine for treating tumor object space face.
Claims (8)
1, the Chinese medicine pharmaceutical composition of a kind of treatment and inhibition tumor is by the preparation that comprises that following raw material components is prepared from: fresh sesame and/or fresh sesame sporophore, Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae.
2, treatment according to claim 1 and suppress the Chinese medicine pharmaceutical composition of tumor, described component is following parts by weight of component: fresh sesame and/or fresh sesame sporophore 60-80, Herba Hedyotidis Diffusae 20-30, Rhizoma Zingiberis Recens 6-10, Radix Glycyrrhizae 3-6, water are an amount of; When wherein containing the compositions of fresh sesame and fresh sesame sporophore, the ratio of fresh sesame and fresh sesame sporophore is 1-5: 5-1.
3, the Chinese medicine pharmaceutical composition of treatment according to claim 2 and inhibition tumor, described component is following parts by weight of component: fresh sesame and/or fresh sesame sporophore 70, Herba Hedyotidis Diffusae 23, Rhizoma Zingiberis Recens 8, Radix Glycyrrhizae 4, water 750; When wherein containing the compositions of fresh sesame and fresh sesame sporophore, the ratio of fresh sesame and fresh sesame sporophore is 1: 1.
4, according to claim 1,2 or 3 pharmaceutical composition, described treatment and the Chinese medicine pharmaceutical composition that suppresses tumor are oral liquid.
5, a kind of Chinese medicine preparation of drug combination method that suppresses and treat tumor of one of claim 1-4 may further comprise the steps:
(1) fresh sesame and/or fresh sesame sporophore, Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae are mixed, be broken into pulpous state with pigment;
(2) with said mixture 50-80 ℃ of continuous stirring thermal response 4-8 hour;
(3) the filtered liquid of above-mentioned thermal agitation reactant mixture was added the retort secondary response 2-4 hour;
(4) liquid with above-mentioned secondary response concentrates, and is condensed into the liquid of proportion 1.05-1.2, carries out packing and promptly gets the pharmaceutical composition that suppresses and treat tumor.
6, according to the inhibition of claim 5 and the Chinese medicine preparation of drug combination method of treatment tumor, the mixed powder of described step (1) is broken into pulpous state under 60-70 ℃ temperature, is 750: 70: 23 in water, fresh sesame and fresh sesame sporophore, Herba Hedyotidis Diffusae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae according to weight ratio: 8: 4 proportioning ratio places retort to stir fully mixing; It is with the abundant stirring reaction 4-8 of paste mixture hour under 50-80 ℃ that the thermal agitation of described step (2) mixes.
7,, according to the inhibition of claim 5 or 6 and the Chinese medicine preparation of drug combination method of treatment tumor, (2) Continuous Heat stirring of described step 6 hours; Described step (3) is filtered stirred reaction mixture and was added the retort secondary response 3 hours.
8, the Chinese medicine pharmaceutical composition of a kind of inhibition of one of claim 1-3 and treatment tumor is in the application of preparation inhibition and medicine for treating tumor object space face.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101129928A CN100556448C (en) | 2005-10-18 | 2005-10-18 | Chinese medicine pharmaceutical composition of a kind of inhibition and treatment tumor and its production and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101129928A CN100556448C (en) | 2005-10-18 | 2005-10-18 | Chinese medicine pharmaceutical composition of a kind of inhibition and treatment tumor and its production and application |
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| Publication Number | Publication Date |
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| CN1745845A true CN1745845A (en) | 2006-03-15 |
| CN100556448C CN100556448C (en) | 2009-11-04 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177792A (en) * | 2016-08-29 | 2016-12-07 | 王建斌 | A kind of Chinese medicine composition treating tumor and preparation method thereof |
| CN113908240A (en) * | 2020-07-08 | 2022-01-11 | 广东臻宝堂中药技术开发有限公司 | Traditional Chinese medicine conditioning formula for gastric cancer patients and preparation method |
-
2005
- 2005-10-18 CN CNB2005101129928A patent/CN100556448C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177792A (en) * | 2016-08-29 | 2016-12-07 | 王建斌 | A kind of Chinese medicine composition treating tumor and preparation method thereof |
| CN113908240A (en) * | 2020-07-08 | 2022-01-11 | 广东臻宝堂中药技术开发有限公司 | Traditional Chinese medicine conditioning formula for gastric cancer patients and preparation method |
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| Publication number | Publication date |
|---|---|
| CN100556448C (en) | 2009-11-04 |
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Granted publication date: 20091104 Termination date: 20171018 |