CN1490025A - Bear gall granular formulation and preparing method thereof - Google Patents
Bear gall granular formulation and preparing method thereof Download PDFInfo
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- CN1490025A CN1490025A CNA031125867A CN03112586A CN1490025A CN 1490025 A CN1490025 A CN 1490025A CN A031125867 A CNA031125867 A CN A031125867A CN 03112586 A CN03112586 A CN 03112586A CN 1490025 A CN1490025 A CN 1490025A
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- weight portion
- fel ursi
- powder
- stevioside
- dextrin
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Abstract
A granular bear gall preparation is prepared from bear gall powder, cyclodextrin, starch, dextrin, sugar, liquorice extract and stevioside. Its advantages are less loss of bioactivity, and high curative effect.
Description
Technical field:
The present invention relates to a kind of Fel Ursi granule and preparation method thereof.
Background technology:
Fel Ursi is the bile of ursidae animal black bear (Selenaretos Thibeta Cuver) or brown bear (Ursusaretos).Fel Ursi is a big rare medicinal herbs in China's pools of traditional Chinese medicine, the history of using existing several thousand in clinical.According to Chinese medicine classics " legendary god of farming book on Chinese herbal medicine opinion ", Tang Materia Medica, Compendium of Material Medica record, the Fel Ursi bitter in the mouth, cool in nature, return spleen, gallbladder, heart channel, nontoxic, the function that have heat clearing away, suppressing the hyperactive liver, makes eye bright; Be used for convulsion with spasms, external treatment conjunctival congestion and swelling pain, laryngopharynx swelling and pain; Consumption is the 0.3-1 gram, mostly is the diffusing clothes of ball, and suitable amount used externally is ground into powder or water is transferred the coating affected part; Fel Ursi also has the body's cholesterol of reduction, reduces multiple pharmacological effect such as hypertension, hyperlipidemia, dissolving Biliary Calculi and resisting fatigue simultaneously, takes for a long time, and is good for health.Domestic existing preparation is " Fel Ursi capsule " a kind of single medicinal material patent medicine preparation only, and other mostly is compound preparation; And health product mainly contain fractional pack Fel Ursi powder (medical material) and bear bile wine, but because extremely bitter, the raw meat of its flavor, easy deliquescence, and its consumption is all less, and this just greatly limits and has weakened practical function of its significant treatment, health care; In order to solve the above-mentioned defective of Fel Ursi powder, more domestic prior art adopts and reduces consumption or use adjuvant to make behind the granule more in a large number that the way of coating solves, but do not see as yet so far the method report that fundamentally solves its hardship, raw meat, easy moisture absorption problem is arranged, so the dose-effect effect of Fel Ursi is not in full use, single Fel Ursi Chinese patent medicine dosage form is single.
Summary of the invention:
One of purpose of the present invention provides a kind of Fel Ursi granule and preparation method thereof, this Fel Ursi granule had both kept original composition of Fel Ursi and style, the natural physiological active and the distinctive therapeutic efficiency that keep Fel Ursi again, fundamentally overcome Fel Ursi and the hardship in preparation thereof, raw meat, damp problem, increase the Fel Ursi preparation, bring into play its multiple diseases prevention better, cure the disease and function of health care and be convenient to transport, preserve, carry, conveniently take, good mouthfeel.
These and other objects of the present invention will and be described and further set forth and explanation by following detailed description.
In the present invention, bear bile buccal tablet comprises:
Fel Ursi powder 50-150 weight portion, cyclodextrin 50-600 weight portion, Radix Glycyrrhizae extractum 50-100 weight portion, starch 100-500 weight portion, dextrin 300-1000 weight portion, sugar part 1000-5000 weight portion, stevioside 0.5-2.5 weight portion.
Further, bear bile buccal tablet of the present invention also comprises:
Mentholum 5-10 weight portion, Oleum menthae 5-10 weight portion, lemon yellow 0.2-1.3 weight portion, chlorophyll copper sodium 2-5 weight portion.
If necessary; Fel Ursi granule of the present invention can also comprise some other additive and excipient; the succedaneum, stay in grade agent, defoamer, thickening agent, quality improver and other the useful additive that comprise Fel Ursi; can certainly be with some raw material among the alternative the present invention of other conventional products, as citric acid, pigment, essence or the like.
Fel Ursi granule of the present invention can replace Fel Ursi powder with fresh bear bile, and the consumption of fresh bear bile is that the amount that the content's index of Fel Ursi powder is calculated equates.
Bear bile buccal tablet of the present invention can prepare as follows, comprises the steps:
A, take by weighing each raw material by proportioning:
Fel Ursi powder 50-150 weight portion, cyclodextrin 50-600 weight portion, starch 100-500 weight portion, dextrin 300-1000 weight portion, sugar part 1000-5000 weight portion, Radix Glycyrrhizae extractum powder 50-100 weight portion, stevioside 0.5-2.5 weight portion, Mentholum 5-10 weight portion, Oleum menthae 5-10 weight portion, lemon yellow 0.2-1.3 weight portion, chlorophyll copper sodium 2-5 weight portion;
B, get Fel Ursi powder and cyclodextrin water and organic solvent dissolving respectively, make solution, to the temperature of 80 degree, stir enclose, reclaim spray-dried clathrate behind the organic solvent at 25 degree Celsius;
C, clathrate and starch, dextrin, sugar part, Radix Glycyrrhizae extractum powder, stevioside, lemon yellow, auxiliary materials and mixing such as chlorophyll copper sodium are made granule, drying;
D, get volatile adjuvant Mentholum and Oleum menthae, make it dissolving after adding ethanol dilution,
E, getting C, to add D airtight more than 4 hours, divides the bag of packing into, promptly gets product.
In the present invention, preferentially use Fel Ursi powder, the preparation method of Fel Ursi powder is that prior art is commonly used.
Fel Ursi granule of the present invention can replace Fel Ursi powder with fresh bear bile, and the consumption of fresh bear bile is that the amount that the content's index of Fel Ursi powder is calculated equates.
If adopt new fresh bear bile, can earlier its dilute with water be placed then autoclave under 0.105MPa steam pressure condition, sterilization treatment 15 minutes, cooling gets final product.
Product of the present invention had both kept original composition of Fel Ursi and style, kept the natural physiological active and the distinctive therapeutic efficiency of Fel Ursi again, and be convenient to transport, preserve, carry, conveniently take, good mouthfeel.
Below further specify the present invention by specific embodiment, but embodiment only be used for the explanation, can not limit the scope of the invention.
The specific embodiment:
In the present invention, if not refer in particular to, all parts, amount are unit of weight, and all raw materials all can be buied from market.
Example 1,
A, take by weighing each raw material by proportioning:
Fel Ursi powder 75 grams, cyclodextrin 100 grams, starch 200 grams, dextrin 400 grams, sugar part 3150 grams, Radix Glycyrrhizae extractum 60 grams, stevioside 2 grams, Mentholum 5 grams, Oleum menthae 5 grams, lemon yellow 0.5 gram, chlorophyll copper sodium 2.5 grams;
B, get Fel Ursi powder and cyclodextrin water and organic solvent dissolving respectively, make solution, to the temperature of 80 degree, stir enclose, reclaim spray-dried clathrate behind the organic solvent at 25 degree Celsius;
C, clathrate and starch, dextrin, sugar part, Radix Glycyrrhizae extractum powder, stevioside, lemon yellow, auxiliary materials and mixing such as chlorophyll copper sodium are made granule, drying, granulate;
D, get volatile adjuvant Mentholum and Oleum menthae, make it dissolving after adding ethanol dilution;
E, get that to add D behind the C airtight more than 4 hours, divide the bag of packing into promptly get 500 bags every bag 8 product that restrains.
Example 2,
A, take by weighing each raw material by proportioning:
Fel Ursi powder 100 grams, cyclodextrin 200 grams, starch 200 grams, dextrin 400 grams, sugar part 3000 grams, Radix Glycyrrhizae extractum 80 grams, stevioside 1 gram, Mentholum 6 grams, Oleum menthae 5 grams, lemon yellow 0.5 gram, chlorophyll copper sodium 2.5 grams;
B, get Fel Ursi powder and cyclodextrin water and organic solvent dissolving respectively, make solution, to the temperature of 80 degree, stir enclose, reclaim spray-dried clathrate behind the organic solvent at 25 degree Celsius;
C, clathrate and starch, dextrin, sugar part, Radix Glycyrrhizae extractum powder, stevioside, lemon yellow, auxiliary materials and mixing such as chlorophyll copper sodium are made granule, drying, granulate;
D, get volatile adjuvant Mentholum and Oleum menthae, make it dissolving after adding ethanol dilution;
E, get that to add D behind the C airtight more than 4 hours, divide the bag of packing into promptly get 500 bags every bag 8 product that restrains.
Example 3,
A, take by weighing each raw material by proportioning:
900 milliliters of new fresh bear biles, Fel Ursi powder 100 grams, cyclodextrin 110 grams, starch 200 grams, dextrin 400 grams, sugar part 3100 grams, Radix Glycyrrhizae extractum 85 grams, stevioside 1 gram, Mentholum 6 grams, Oleum menthae 5 grams, lemon yellow 0.5 gram, chlorophyll copper sodium 2.5 grams;
B, get Fel Ursi powder and cyclodextrin water and organic solvent dissolving respectively, make solution, to the temperature of 80 degree, stir enclose, reclaim spray-dried clathrate behind the organic solvent at 25 degree Celsius;
C, clathrate and starch, dextrin, sugar part, Radix Glycyrrhizae extractum powder, stevioside, lemon yellow, chlorophyll copper sodium etc. auxiliary materials and mixing, is made granule, drying;
D, get volatile adjuvant Mentholum and Oleum menthae, make it dissolving after adding ethanol dilution;
E, getting C, to add D airtight more than 4 hours, divides the bag of packing into promptly get 500 bags every bag 8 product that restrains.
Claims (4)
1, a kind of Fel Ursi granule is characterized in that: comprise Fel Ursi powder 50-150 weight portion, cyclodextrin 50-600 weight portion, starch 100-500 weight portion, dextrin 300-1000 weight portion, sugar part 1000-5000 weight portion, Radix Glycyrrhizae extractum 50-100 weight portion, stevioside 0.5-2.5 weight portion.
2, bear bile buccal tablet as claimed in claim 1 is characterized in that: also comprise Mentholum 5-10 weight portion, Oleum menthae 5-10 weight portion, lemon yellow 0.2-1.3 weight portion, chlorophyll copper sodium 2-5 weight portion.
3, bear bile buccal tablet as claimed in claim 1 or 2 is characterized in that: can replace Fel Ursi powder with fresh bear bile, the consumption of fresh bear bile is that the amount that the content's index of Fel Ursi powder is calculated equates.
4, the particulate preparation method of a kind of Fel Ursi as claimed in claim 1 is characterized in that: comprise the steps:
A, take by weighing each raw material by proportioning:
Fel Ursi powder 50-150 weight portion, cyclodextrin 50-600 weight portion, starch 100-500 weight portion, dextrin 300-1000 weight portion, sugar part 1000-5000 weight portion, Radix Glycyrrhizae extractum powder 50-100 weight portion, stevioside 0.5-2.5 weight portion, Mentholum 5-10 weight portion, Oleum menthae 5-10 weight portion, lemon yellow 0.2-1.3 weight portion, chlorophyll copper sodium 2-5 weight portion.
B, get Fel Ursi powder and cyclodextrin water and organic solvent dissolving respectively, make solution, to the temperature of 80 degree, stir enclose, reclaim spray-dried clathrate behind the organic solvent at 25 degree Celsius.
C, clathrate and starch, dextrin, sugar part, Radix Glycyrrhizae extractum powder, stevioside, lemon yellow, auxiliary materials and mixing such as chlorophyll copper sodium are made granule, drying.
D, get volatile adjuvant Mentholum and Oleum menthae, make it dissolving after adding ethanol dilution,
E, getting C, to add D airtight more than 4 hours, divides the bag of packing into, promptly gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031125867A CN1490025A (en) | 2003-06-18 | 2003-06-18 | Bear gall granular formulation and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031125867A CN1490025A (en) | 2003-06-18 | 2003-06-18 | Bear gall granular formulation and preparing method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1490025A true CN1490025A (en) | 2004-04-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA031125867A Pending CN1490025A (en) | 2003-06-18 | 2003-06-18 | Bear gall granular formulation and preparing method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906046A (en) * | 2015-05-13 | 2015-09-16 | 上海中医药大学 | Method covering traditional Chinese medicine particle fishy smell |
| CN110478304A (en) * | 2019-08-20 | 2019-11-22 | 广州市金熊大健康科技有限公司 | A kind of toothpaste containing bear gall microcapsules |
| CN113499308A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall oral liquid and preparation method and application thereof |
| CN113499348A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall sugar-free buccal tablet and preparation method and application thereof |
-
2003
- 2003-06-18 CN CNA031125867A patent/CN1490025A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906046A (en) * | 2015-05-13 | 2015-09-16 | 上海中医药大学 | Method covering traditional Chinese medicine particle fishy smell |
| CN110478304A (en) * | 2019-08-20 | 2019-11-22 | 广州市金熊大健康科技有限公司 | A kind of toothpaste containing bear gall microcapsules |
| CN110478304B (en) * | 2019-08-20 | 2022-07-05 | 广州市金熊大健康科技有限公司 | Toothpaste containing bear gall microcapsule |
| CN113499308A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall oral liquid and preparation method and application thereof |
| CN113499348A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall sugar-free buccal tablet and preparation method and application thereof |
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