CN1486730A - Capsule prepn for regulating blood fat and blood pressure - Google Patents
Capsule prepn for regulating blood fat and blood pressure Download PDFInfo
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- CN1486730A CN1486730A CNA031418341A CN03141834A CN1486730A CN 1486730 A CN1486730 A CN 1486730A CN A031418341 A CNA031418341 A CN A031418341A CN 03141834 A CN03141834 A CN 03141834A CN 1486730 A CN1486730 A CN 1486730A
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- radix astragali
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- salvianolate
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Abstract
The present invention relates to health care food, and is especially one Chinese medicine capsule preparation capable of regulating blood fat and blood pressure. The capsule preparation is prepared with red sage for promoting blood circulation, notoginseng for eliminating blood clots and nourishing blood, astragalus root for benefiting vital energy and aloe as adjuvant for clearing away heat and regulating vital energy, and can prevent hyperlipemia and hypertension caused by vital energy asthma and blood clots. Application shows that the capsule preparation has obvious effect of regulating blood fat and blood pressure.
Description
Technical field
The invention belongs to field of health care food, be specifically related to a kind of energy blood lipid regulation of Chinese crude drug raw material and capsule preparations of blood pressure of containing.
Background technology
Main effective ingredient in the Chinese medicine Radix Notoginseng is an arasaponin, and pharmacological evaluation proof Radix Notoginseng total glucosides can significantly improve erythrocyte deformability, reduces erythrocyte aggregation index and whole blood viscosity, thereby improves blood circulation.The clinical discovery Radix Notoginseng total glucosides reduces the blood pressure that increases two approach: increase CO; reduce diastolic pressure (DBP) and alleviate arteriolar spasm; Radix Notoginseng total glucosides has protection superoxide dismutase (SOD) activity in addition; the block film lipid peroxidation; remove oxygen-derived free radicals; prevent that the cellularity function is impaired, thereby improve cell, alleviate the symptom that cardiovascular and cerebrovascular vessel cause because of ischemia, anoxia ischemia, anoxybiotic toleration.
The main water soluble ingredient salvianolate of Radix Salviae Miltiorrhizae can distend the blood vessels, and brings high blood pressure down.Salvianolate can improve the excretory prostacyclin (PGI of endotheliocyte
2) generation, PGI
2The vasoactive wall, blood vessel dilating brings high blood pressure down, and plasminogen activation becomes fibrinolysin simultaneously, and solution fibrin makes thromboembolism, improves hemorheological properties; Radix Salviae Miltiorrhizae can also suppress platelet and discharge 5-HT, reduces thromboxane (TXA
2), reduce platelet aggregation, promote the reparation and the regeneration of tissue.Zoopery shows, salvianolate can make that rat blood pressure obviously reduces, onset in 30 minutes after the administration, acts on more than the constant and sustainable 2h.
The Radix Astragali makes erythrocyte rigidity index, the whole blood height of representing erythrocyte deformability cut viscosity and represents that the erythrocyte aggregation index, whole blood of erythrocyte aggregation is low to be cut viscosity and significantly descend, especially it is more remarkable to cut viscosity degradation with the whole blood height, its mechanism and the Radix Astragali can change the film surface charge, increase erythrocyte membrane fluidity, and the α helical content is relevant in the increase albumen.More pharmacological research shows that the Radix Astragali can be protected erythrocyte deformability, strengthens the hemopoietic system function, reduces platelet adhesion rate, reduces thrombosis, and certain expansion vascular function is arranged, and brings high blood pressure down.On the other hand, the Radix Astragali is by increasing myocardial contraction, and the expansion peripheral vessels brings high blood pressure down, and improves tissue perfusion.But Radix Astragali inducing diuresis to remove edema plays the effect of blood pressure regulation.
Radix Notoginseng and Radix Salviae Miltiorrhizae all can prevent the formation of atheromatous plaque and promote it to disappear, and blood fat reducing improves blood " dense, sticking, poly-, coagulate " state, reduces the generation of cardiovascular and other thrombotic diseases.
The Radix Notoginseng blood fat reducing is remarkable, and particularly to triglyceride, reduction rate is up to 51%.Radix Notoginseng total glucosides can weaken fibrinous bridge linking effect, make patient's whole blood height cut the low viscosity of cutting, plasma viscosity, it can reduce the surface tension at erythrocyte and the formed interface of blood plasma simultaneously, increase erythrocyte deformability, make packed cell volume, erythrocyte aggregation index, erythrocyte electrophoretic time all obviously descends, and improves hemorheology.
Radix Salviae Miltiorrhizae can significantly suppress the synthetic of cell endogenous cholesterol, and has an effect of lipotropism protein oxidation, oxidation lipoprotein electrophoresis mobility is obviously slack-off, the toxic action of obvious minimizing of lipid peroxide contents and oxidation lipoprotein pair cell obviously weakens in the oxidation lipoprotein, can be used for atherosclerotic control.Clinical observation Treated with Radix Salviae Miltiorrhizae coronary heart disease hyperlipemia, treatment back blood lipid level obviously descends, and whole blood viscosity, plasma viscosity, platelet aggregation average also obviously improve before the treatment.Radix Salviae Miltiorrhizae can reduce blood cholesterol and triglyceride, improves hemorheology index, effectively reduces the anginal outbreak of patient, improves the quality of living.
The Radix Astragali is by reaching the effect of benefiting qi and raising yang, promoting the circulation of QI to induce diuresis for the multidirectional adjusting of blood circulation and lipid level.The patient that Radix Astragali treatment blood fat, blood viscosity raise, every index is all than significantly descending before the treatment.Infer that from zoopery the Radix Astragali makes liver owing to the synthetic compensatory increase process of lipoprotein that hypoproteinemia brings out is inhibited by rising rat plasma albumin.Simultaneously, the Radix Astragali also may directly act on the synthetic of liver inhibition cholesterol and triglyceride.Thereby play the effect of blood fat reducing, blood viscosity lowering.
Aloe also has certain effect for reducing fat.Research worker adopts high fat diet nursing method to set up rabbit As model and gavages Aloe lyophilization extract, and the result shows that barbados aloe lyophilization extract 0.2g/kgd gavages the As rabbit 6-Keto-PGF that can obviously raise
1 αContent reduces LPO content, reduces area of aorta atherosclerotic plaque, and this effect may and be regulated PGI with its antioxidation
2/ TXA
2Balancing is relevant.
Summary of the invention
The purpose of this invention is to provide a kind of blood lipid regulation and blood pressure capsule preparations, nonhazardous can improve people's health level.
Capsule preparations formulation principle of the present invention adopts Radix Salviae Miltiorrhizae to invigorate blood circulation, and the Radix Notoginseng blood stasis dispelling is enriched blood, and is equipped with Radix Astragali QI invigorating, and QI and blood must be mended, the stasis of blood new life that dispels, and the prosperous then blood of gas is given birth to, and gas fills that then blood is smooth, three medicines mutually 5, blood stasis dispelling is not just hindered.Help Aloe heat clearing away purging FU-organs gas simply, harmonizing the functional activities of vital QI helps QI-blood circulation, effectively prevents blood stasis due to qi deficiency to cause hyperlipidemia and hypertension.
Capsule preparations of the present invention is made by the following weight proportion raw material, in per 100 gram finished products, contains salvianolate 10-30%, Radix Astragali extract 20-40%, Radix Notoginseng 20-40%, Aloe 5-20%, dextrin 5-10%.
Medical material of the present invention is all selected the qualified decoction pieces that reaches regulation under each medical material item of Pharmacopoeia of the People's Republic of China version in 2000 for use.
The present invention prepares by following method,
1) preparation Radix Astragali extract
Take by weighing the Radix Astragali, chopping is doubly measured reflux, extract, 2-4 time with being total to 10-20 with the 50-90 ethanol water, extracts altogether 2-4 hour, filters decompression filtrate recycling ethanol.The ethanol of the Radix Astragali residue behind the total Saponin of extraction is volatilized only, decoct 2-4 time with 10-20 times of water gaging, 2-4 hour, filter, distilling under reduced pressure after the above-mentioned filtrate merging, drying gets Radix Astragali extract.
2) preparation salvianolate
The Radix Salviae Miltiorrhizae input of chopping is boiled and irrigated by lifting water to a higher level with a water pump, etc., boil with 10-20 times of water gaging and carry 2-4 time, extracted two hours at every turn.Extract is evaporated to 1.5-3 times of Radix Salviae Miltiorrhizae crude drug weight after filtering, by the macroporous resin adsorption post, and the washing decontamination, reuse different concentration ethanol gradation eluting, described concentration of alcohol is 5-60%, and HPLC follows the tracks of detection, collects above-mentioned eluent, concentrating under reduced pressure, add concentration of alcohol to 50-90%, the supernatant is concentrated into dried, further drying and crushing, get the sepia salvianolate, content 〉=30% (g/g).
3) Radix Notoginseng, Aloe directly are used as medicine after pulverizing.
4) mix:
The powder that above-mentioned steps makes takes by weighing full recipe quantity by proportioning separately, adds 10% dextrin, mix homogeneously.Press hygiology, the physical and chemical inspection of regulation under the health food item.
5) fill capsule:
After the assay was approved, fill becomes No. 1 capsule (250mg/ grain).
The end product quality standard
With the salvianolate is one of quality control index.Poly phenolic acid of Radix Salviae Miltiorrhizae salt content 〉=30% (g/g) that control is added.Because one of Radix Notoginseng, the Radix Astragali and aloetic main active are all Saponin, be that the quality standard of final product is guaranteed end product quality by content with the total Saponin of modern chemistry component monitoring technology for detection.Content 〉=the 10%mg/g of total Saponin of capsule preparations of the present invention.
Capsule preparations of the present invention is on probation through the crowd, and the result shows the effect with tangible blood lipid regulation and blood pressure.
Choose 197 routine eligible patientses, age 24-66 year, male's 123 examples, women's 74 examples, wherein Clinical Laboratory hyperlipidemia 47 examples, vascular hypertension 102 examples, hyperlipidemia and hypertension disease 48 examples.Took capsule preparations of the present invention 2 months, the result shows, the outside sign of 91% hyperlipidemia and hypertension disease is obviously improved after one month, the hyperlipidemia of P＜0.01.87%, hypertensive physiology, biochemistry detection index have more obviously to be improved, P＜0.05. outside sign of 98% hyperlipidemia and hypertension disease after two months obviously improves, and the hyperlipidemia of P＜0.001.97%, hypertensive physiology, biochemistry detection index reach normal level.
The specific embodiment
Embodiment 1,
The preparation Radix Astragali extract: take by weighing 100 kilograms of Radixs Astragali, chopping, respectively with 70% ethanol water reflux, extract, twice, 10 times of amounts for the first time, 90min, the second time 8 times of amounts, 60min.Filter decompression filtrate recycling ethanol.The ethanol of the Radix Astragali residue behind the total Saponin of extraction is volatilized totally, decoct three times with 6 times of water gagings, each 60 minutes, filter, distilling under reduced pressure after all filtrates merging, drying gets 24 kilograms of Radix Astragali extracts.
Prepare salvianolate: 100 kilograms of inputs of Radix Salviae Miltiorrhizae of chopping are boiled irrigate by lifting water to a higher level with a water pump, etc., boil with 6,3,2.5 times of water gagings successively at 90-100 ℃ and carry 3 times, each extraction time is two hours.Extract is evaporated to 2.5 times of Radix Salviae Miltiorrhizae crude drug weight after filtering, and the macroporous resin adsorption post by 3 times of crude drug weight washes decontamination with water, reuse aquiferous ethanol gradation eluting, aquiferous ethanol concentration is 50%, and HPLC follows the tracks of detection, collects poly phenolic acid of Radix Salviae Miltiorrhizae salinity 〉=30% ethanol elution, be evaporated to 0.1 times of crude drug amount, adding ethanol is 85% to concentration of alcohol, and the supernatant is concentrated into dried, further drying and crushing, get the sepia salvianolate, 64 kilograms.Recording content is 62%.
Standby after Radix Notoginseng, the Aloe pulverizing.
Mix: with the above-mentioned powder that makes, get 18 kilograms of Radix Astragali extracts, 6 kilograms of salvianolates, 18 kilograms of Radix Notoginseng powder, 6 kilograms of Aloe powder add 4.8 kilograms in dextrin, mix homogeneously.Press hygiology, the physical and chemical inspection of regulation under the health food item.
The fill capsule: after the assay was approved, fill becomes No. 1 capsule (250mg/ grain).
After hygiology, physical and chemical inspection were qualified, the content that records the total Saponin of capsule of the present invention was 19mg/g, and capsular loading amount and content uniformity all meet the regulation under the health food item.
Claims (3)
1, the capsule preparations of a kind of blood lipid regulation and blood pressure is characterized in that being made by the following weight proportion raw material, in per 100 gram finished products, contains salvianolate 10-30%, Radix Astragali extract 20-40%, Radix Notoginseng 20-40%, Aloe 5-20%, dextrin 5-10%.
2, by the capsule preparations of described blood lipid regulation of claim 1 and blood pressure, it is characterized in that making, in per 100 gram finished products, contain salvianolate 22%, Radix Astragali extract 33%, Radix Notoginseng 33%, Aloe 11%, dextrin 10% by the following weight proportion raw material.
3, by the preparation method of the capsule preparations of the described blood lipid regulation of claim 1 and blood pressure, it is characterized in that by being undertaken by following method and step,
1) preparation Radix Astragali extract
Take by weighing the Radix Astragali, chopping, ethanol water reflux, extract, 2-4 hour, decompression filtrate recycling ethanol.After extracting total Saponin, the volatilization of the ethanol of Radix Astragali residue is clean, and decocting boils, and filters, and filtrate merges distilling under reduced pressure, and drying gets Radix Astragali extract.
2) preparation salvianolate
Radix Salviae Miltiorrhizae shreds, and decocting in water is carried 2-4 time, and extract filters the back concentrating under reduced pressure, the macroporous resin adsorption post, and the washing decontamination, different concentration ethanol gradation eluting, HPLC follows the tracks of detection, collects eluent, concentrating under reduced pressure, drying and crushing gets the sepia salvianolate.
3) pulverize Radix Notoginseng, Aloe.
4) mix:
The above-mentioned powder that makes takes by weighing full recipe quantity by proportioning, adds 10% dextrin, mix homogeneously, check.
5) fill capsule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031418341A CN1486730A (en) | 2003-07-24 | 2003-07-24 | Capsule prepn for regulating blood fat and blood pressure |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031418341A CN1486730A (en) | 2003-07-24 | 2003-07-24 | Capsule prepn for regulating blood fat and blood pressure |
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| CN1486730A true CN1486730A (en) | 2004-04-07 |
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| CNA031418341A Pending CN1486730A (en) | 2003-07-24 | 2003-07-24 | Capsule prepn for regulating blood fat and blood pressure |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101439078B (en) * | 2007-11-22 | 2012-03-28 | 天津天士力制药股份有限公司 | Chinese medicine granule containing astragalus extract and preparation method thereof |
| CN102640825A (en) * | 2012-04-23 | 2012-08-22 | 北京绿源求证科技发展有限责任公司 | Lipid-lowering tea for regulating blood lipid |
| CN102669339A (en) * | 2012-05-20 | 2012-09-19 | 北京绿源求证科技发展有限责任公司 | Food hypolipidemic tea granule for regulating blood fat |
| CN103461983A (en) * | 2013-07-18 | 2013-12-25 | 浙江劲膳美生物科技有限公司 | Special diet for people with stagnant blood constitution |
| WO2018171585A1 (en) * | 2017-03-21 | 2018-09-27 | 中国中医科学院中医基础理论研究所 | Chinese medicine composition for lowering blood lipid |
-
2003
- 2003-07-24 CN CNA031418341A patent/CN1486730A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101439078B (en) * | 2007-11-22 | 2012-03-28 | 天津天士力制药股份有限公司 | Chinese medicine granule containing astragalus extract and preparation method thereof |
| CN102640825A (en) * | 2012-04-23 | 2012-08-22 | 北京绿源求证科技发展有限责任公司 | Lipid-lowering tea for regulating blood lipid |
| CN102669339A (en) * | 2012-05-20 | 2012-09-19 | 北京绿源求证科技发展有限责任公司 | Food hypolipidemic tea granule for regulating blood fat |
| CN102669339B (en) * | 2012-05-20 | 2013-08-14 | 北京绿源求证科技发展有限责任公司 | Food hypolipidemic tea granule for regulating blood fat |
| CN103461983A (en) * | 2013-07-18 | 2013-12-25 | 浙江劲膳美生物科技有限公司 | Special diet for people with stagnant blood constitution |
| CN103461983B (en) * | 2013-07-18 | 2015-04-22 | 浙江劲膳美生物科技有限公司 | Special diet for people with stagnant blood constitution |
| WO2018171585A1 (en) * | 2017-03-21 | 2018-09-27 | 中国中医科学院中医基础理论研究所 | Chinese medicine composition for lowering blood lipid |
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