CN1483446A - Traditional Chinese medicine for treating neurosism, extracting process, formation process and use thereof - Google Patents
Traditional Chinese medicine for treating neurosism, extracting process, formation process and use thereof Download PDFInfo
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- CN1483446A CN1483446A CNA03132231XA CN03132231A CN1483446A CN 1483446 A CN1483446 A CN 1483446A CN A03132231X A CNA03132231X A CN A03132231XA CN 03132231 A CN03132231 A CN 03132231A CN 1483446 A CN1483446 A CN 1483446A
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Abstract
The present invention discloses a Chinese medicine for curing neurosism, and its preparation method. Its preparation process includes the following steps: using the Chinese medicinal materials of gastrodia root, pseudostellaria root, schisandra berry and ophiopogon tuber as raw material, respectively extracting them, mixing their extracts, drying to obtain their mixed dried extract, pulverizing said mixed dried extract to obtain fine powder, adding proper auxiliary material, mixing them uniformly, drying, sterilizing and capsulizing so as to obtain the invented product.
Description
Technical field
The present invention relates to a kind of Chinese medicine, exactly is the Chinese medicine of diseases such as the insomnia that causes of a kind of neurasthenia of treatment, hypertension, cervical spondylosis, forgetful, dizzy, headache.
Background technology
Along with the develop rapidly of society and the fierceness day by day of struggle for existence, increasing people are subjected to psychology and spiritual pressure, and the neurasthenia occurs.
The neurasthenia shows as spirit easily excitement and fatiguability, is nervous, emotion symptoms such as worry and irritability, and neurological disorder such as muscular tone pain and sleep disorder.China's mental sickness classification remains with this diagnosis of neurasthenia, and has formulated diagnostic criteria, makes the clinical diagnosis standardization.
Primary disease is more common in person between twenty and fifty, and the women is more than the male, and the brain worker is more than physical labourer.According to clinical manifestation, primary disease can belong to the traditional Chinese medical science and " be insomnia " among " dizzy " " cardiopalmus " categories such as " melancholia ".
According to Shanghai Mental Health Center's introduction, the whole world has approximately that 1/3 adult is had a sleepless night, the torment of disease such as forgetful, dizzy.
The neurasthenic Chinese patent medicine of common in the market treatment has Radix Et Caulis Acanthopanacis Senticosi tablet, brain spirit element, nourishing brain pill, nourishing blood to tranquillize the mind sheet etc., but general onset is slow, weak curative effect, and cure rate is lower, and there is defective in Western medicine aspect safety and the dependency.
Summary of the invention
The purpose of this invention is to provide a kind of rapid-action, good effect, cure rate height, the neurasthenic Chinese medicine of treatment safe in utilization.
The neurasthenic Chinese medicine of a kind of treatment is characterized in that being made up of the following raw material medicaments thing, and its composition by weight is:
Rhizoma Gastrodiae 400~900 Radix Pseudostellariaes (Radix Ginseng, Radix Ginseng Rubra, Radix Codonopsis, Radix Panacis Quinquefolii) 160~360
80~180 Radix Ophiopogonis 160~360 of Fructus Schisandrae Chinensis
Its preferable composition by weight is:
Rhizoma Gastrodiae 600 Radix Pseudostellariaes (Radix Ginseng, Radix Ginseng Rubra, Radix Codonopsis, Radix Panacis Quinquefolii) 240
120 Radix Ophiopogonis 240 of Fructus Schisandrae Chinensis
The extraction process of the neurasthenic Chinese medicine of above-mentioned treatment is characterized in that:
(1) take by weighing Rhizoma Gastrodiae, Fructus Schisandrae Chinensis powder is broken into coarse powder, adds soak with ethanol, adds ethanol and carries out percolation, collects percolate, reclaims ethanol, water-bath is concentrated into extractum;
(2) take by weighing Radix Ophiopogonis, Radix Pseudostellariae is ground into fragment, adds decocting in water and fries in shallow oil repeatedly, collecting decoction filters, filtrate concentrates and precipitate with ethanol, reclaims ethanol, water-bath is concentrated into extractum;
(3) with above-mentioned extractum drying under reduced pressure to dried cream;
In the said method, get Rhizoma Gastrodiae, Fructus Schisandrae Chinensis coarse powder with 70% soak with ethanol, percolation, collect the percolate of 12~16 times of amounts, Radix Ophiopogonis, Radix Pseudostellariae fragment are fried in shallow oil 1~3 time with the decocting in water of 8~12 times of amounts, and each 1 hour, filtrate was concentrated into relative density and is about 1.15 under 50 ℃, and alcohol is sink to, and to contain alcohol amount be 70%, reclaim ethanol, water-bath is concentrated into extractum, and 70 ℃ of drying under reduced pressure are to dried cream.
The moulding process of the neurasthenic Chinese medicine of above-mentioned treatment is characterized in that:
Dried cream powder is broken into fine powder, adds appropriate amount of starch, silica mixture, spray into the ethanol liquid of 5% polyacrylic acid IV resin, coating, drying is sieved, and sterilization incapsulates.
In the said method:
(1) part by weight of starch, silicon dioxide and polyacrylic resin is 1: 0.8~1.2: 0.06~0.09;
(2) weight of starch, silicon dioxide and polyacrylic resin and be 0.2~0.3 times of dry powder;
It makes dosage form can be capsule, tablet, granule, pill, oral liquid, syrup.
This Chinese medicine is applicable to insomnia, forgetful, dizzy, the headache symptom that neurasthenia, hypertension, cervical spondylosis cause.
Doubly amount described in the present invention is meant the ratio of volume (L) and weight (Kg), and the concentration unit of each material is a GB unit, and the ethanol liquid of 5% polyacrylic resin is meant the product of 5 gram polyacrylic resins in 100ml ethanol.
The polyacrylic acid IV resin that adopts among the present invention is good filmogen, mixes thoroughly with an amount of polyacrylic acid IV resin before encapsulated, and drying can improve the humidity-proof ability of capsule 's content, has increased the flowability of content simultaneously, is convenient to mechanical packaging.
Chinese medicine of the present invention is under the guidance of motherland's Traditional Chinese medical theory, at the pathological change of the many deficiency of both QI and YIN of neurasthenic patient, through research repeatedly, in conjunction with clinical experience for many years, according to monarch, minister, the combination principle helping, make, selected four flavor Chinese herbal medicine, scientific formulation, is rationally wanted and not numerous, Rhizoma Gastrodiae endogenous wind stopping relieving convulsion wherein, suppressing the hyperactive liver and subsiding YANG is used for liver-wind stirring up internally, disease such as dizzy, headache due to the excessive rising of liver-YANG; The Fructus Schisandrae Chinensis nourishing kidney of astringing the lung, the arresting sweating that promotes the production of body fluid, arresting seminal emission antidiarrheal, mind tranquilizing and the heart calming is used for the treatment of diseases such as cardiopalmus, insomnia, dreaminess; The Radix Pseudostellariae tonifying QI to produce body fluid, the relieving restlessness that clears away heart-fire Radix Ophiopogonis, YIN nourishing and the production of body fluid promoting, four medicines are instrumental ensembled the effect of invigorating brain and relieving mental uneasiness supplementing QI and nourishing YIN, agree with the neurasthenia, insomnia forgetfulness, the etiology and pathogenesis of dizziness headache, full side has supplementing QI and nourishing YIN, the function that suppressing the hyperactive liver is calmed the nerves, cure mainly the deficiency of both QI and YIN neurasthenia of liver-wind stirring up internally that holds concurrently, card is seen insomnia, dizziness, headache, cardiopalmus, symptom such as forgetful, quite obtains good effect.
The present invention has carried out pharmacodynamic study, and acute toxicity testing and long term toxicity test prove that pharmaceutical effectiveness of the present invention is definite, and toxic and side effects is little.
Pharmacodynamic study:
1, after the insufficiency of heart-QI model mice was used Chinese medicine chin or cheek brain capsule of the present invention, the anxiety that suspension is caused had obvious inhibitory action; Prolonged the length of one's sleep; Muscular tension increases, the time lengthening of standing; Adopting the water maze method to record memory increases; Hypoxia endurance time prolongs under the normal pressure; Insufficiency of heart-QI mice heart rate is recovered; 2, after normal mouse was used the chin or cheek brain capsule, the anxiety that forced swimming method and suspension method are caused had tangible sedation; Obviously prolonged the length of one's sleep of mice; Immunologic function is significantly improved, mononuclear phagocyte phagocytic index and activate the phagocytic capacity are obviously increased, the mice serum amboceptor significantly raises; 3, the hypertension to neuroendocrine type hypertension model rat has tangible reduction effect; Heart rate obviously recovers; The length of one's sleep, significant prolongation had the obvious synergistic effect with pentobarbital sodium; As seen the test of water maze method increases the memory of rat model, and the time that stops in the labyrinth obviously shortens; With the head-breaking test as seen, the chin or cheek brain capsule obviously prolongs the time of opening one's mouth after rat breaks end.In a word, the chin or cheek brain capsule has tangible tranquillizing and allaying excitement, blood pressure when reducing pathological state to pathological state and normal large and small Mus, can also improve the immunologic function of normal mouse.Effect that so brain-strengthening, QI invigorating is arranged and calm the nerves.
Acute toxicity testing
The oral maximum dosage-feeding of mice of Chinese medicine chin or cheek brain capsule of the present invention is 240g crude drug/kg,, calculate by kg body weight, be equivalent to 1333 times of Coming-of-Age Day consumption 10.8g, press body surface area and calculate, be equivalent to 171 times; It is 42.427 crude drugs/kg that intraperitoneal administration records its LD50, its 95% credible 37.217~48.717g crude drug/kg that is limited to.Illustrate that chin or cheek brain capsule oral toxicity is low, clinical practice is safer.
Long term toxicity test
Chinese medicine of the present invention chin or cheek brain capsule to mice by 7.78,21.30 and 58.32g crude drug/kg (press body surface area calculating, be equivalent to 8,22 and 60 times of clinical Coming-of-Age Day consumption 10.8g crude drug, calculate by kg body weight, be equivalent to 43,118 and 324 times) 12 weeks of continuous use (1.0ml/100g body weight, every day 2 times) and after 2 weeks of drug withdrawal, the result shows: the chin or cheek brain capsule does not all have obvious influence (except that indivedual indexs) to indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat.The internal organs naked eyes do not find that difference changes and the histological examination result shows that after 12 weeks of medication and 2 weeks of drug withdrawal, each internal organs of rat all do not have obvious change.Toxicity was little after chin or cheek brain capsule rat long-term prescription was described, did not also have the difference reaction after the drug withdrawal, application safety.
Compare with similar Chinese patent medicine, this Chinese medicine good effect, dose is little, the cure rate height, and rapid-action, have no side effect, for vast neurastheniac provides preferred a selection.
The patient takes mode: oral, one time 3,3 times on the one.
The specific embodiment
Embodiment 1:
Composition by weight of the present invention is:
Rhizoma Gastrodiae 7200 gram Radix Pseudostellariaes 2880 grams
Fructus Schisandrae Chinensis 1440 gram grams Radix Ophiopogonis 2880
The method of preparation is:
1, by above-mentioned weight take by weighing Rhizoma Gastrodiae, Fructus Schisandrae Chinensis powder is broken into coarse powder, with according to fluid extract and extractum item percolation down, selects for use the ethanol that contains alcohol amount 70% to make solvent, soaks earlier, carries out percolation again, the percolate of 12 times of amounts of collection, decompression recycling ethanol gets medicinal liquid;
2, by above-mentioned weight take by weighing Radix Ophiopogonis, Radix Pseudostellariae is ground into fragment, adding decocting in water fries in shallow oil three times, each 1 hour, amount of water was Radix Ophiopogonis, Radix Pseudostellariae weight 10 times, merges three times decocting liquid, filter, it is 1.15 (50 ℃) that filtrate is concentrated into relative density, adds ethanol and makes the alcohol amount of containing 70%, filters, filtrate recycling ethanol gets medicinal liquid;
3, above-mentioned two medicinal liquids are condensed into thick paste, drying under reduced pressure is to dried cream;
4, dried cream powder is broken into fine powder, add appropriate amount of auxiliary materials, select for use starch 300 gram, silicon dioxide 300 grams as filler, selecting for use polyacrylic acid IV resin 24 grams to be made into 5% ethanol liquid is filmogen, with its mixing, drying, sterilization, coating, incapsulate, make 12000 the chin or cheek brain capsules.
The formulation by weight of each component of the present invention also can be:
Rhizoma Gastrodiae 400~900 Radix Pseudostellariaes (Radix Ginseng, Radix Ginseng Rubra, Radix Codonopsis, Radix Panacis Quinquefolii) 160~360
80~180 Radix Ophiopogonis 160~360 of Fructus Schisandrae Chinensis
Claims (8)
1, the neurasthenic Chinese medicine of a kind of treatment is characterized in that being made up of the following raw material medicaments thing, and its composition by weight is:
Rhizoma Gastrodiae 400~900 Radix Pseudostellariaes (Radix Ginseng, Radix Ginseng Rubra, Radix Codonopsis, Radix Panacis Quinquefolii) 160~360
80~180 Radix Ophiopogonis 160~360 of Fructus Schisandrae Chinensis
2, the neurasthenic Chinese medicine of treatment according to claim 1 is characterized in that its composition by weight is:
Rhizoma Gastrodiae 600 Radix Pseudostellariaes (Radix Ginseng, Radix Ginseng Rubra, Radix Codonopsis, Radix Panacis Quinquefolii) 240
120 Radix Ophiopogonis 240 of Fructus Schisandrae Chinensis
3, the extraction process of the neurasthenic Chinese medicine of treatment according to claim 1 and 2 is characterized in that:
(1) take by weighing Rhizoma Gastrodiae, Fructus Schisandrae Chinensis powder is broken into coarse powder, adds soak with ethanol, adds ethanol and carries out percolation, collects percolate, reclaims ethanol, water-bath is concentrated into extractum;
(2) take by weighing Radix Ophiopogonis, Radix Pseudostellariae is ground into fragment, adds decocting in water and fries in shallow oil repeatedly, collecting decoction filters, filtrate concentrates and precipitate with ethanol, reclaims ethanol, water-bath is concentrated into extractum;
(3) with above-mentioned extractum drying under reduced pressure to dried cream;
4, the extraction process of the neurasthenic Chinese medicine of treatment according to claim 3 is characterized in that:
Get Rhizoma Gastrodiae, Fructus Schisandrae Chinensis coarse powder with 70% soak with ethanol, percolation, collect the percolate of 12~16 times of amounts, Radix Ophiopogonis, Radix Pseudostellariae fragment are fried in shallow oil 1~3 time with the decocting in water of 8~12 times of amounts, each 1 hour, filtrate is concentrated into relative density and is about 1.15 under 50 ℃, and alcohol is sink to that to contain alcohol amount be 70%, reclaims ethanol, water-bath is concentrated into extractum, and 70 ℃ of drying under reduced pressure are to dried cream.
5, the moulding process of the neurasthenic Chinese medicine of treatment according to claim 1 and 2 is characterized in that:
Dried cream powder is broken into fine powder, adds appropriate amount of starch, silica mixture, spray into the ethanol liquid of 5% polyacrylic acid IV resin, coating, drying is sieved, and sterilization incapsulates.
6, the moulding process of the neurasthenic Chinese medicine of treatment according to claim 5 is characterized in that:
(1) part by weight of starch, silicon dioxide and polyacrylic resin is 1: 0.8~1.2: 0.06~0.09;
(2) weight of starch, silicon dioxide and polyacrylic resin and be 0.2~0.3 times of dry powder;
7, the neurasthenic Chinese medicine of treatment according to claim 1 and 2, it is characterized in that making dosage form can be capsule, tablet, granule, pill, oral liquid, syrup.
8, the purposes of the neurasthenic Chinese medicine of treatment according to claim 1 and 2 is characterized in that insomnia, forgetful, dizzy, headache symptom that this Chinese medicine is applicable to neurasthenia, hypertension, cervical spondylosis and causes.
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CN 03132231 CN1214811C (en) | 2003-07-30 | 2003-07-30 | Traditional Chinese medicine for treating neurosism, extracting process, formation process and use thereof |
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CN 03132231 CN1214811C (en) | 2003-07-30 | 2003-07-30 | Traditional Chinese medicine for treating neurosism, extracting process, formation process and use thereof |
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CN1214811C CN1214811C (en) | 2005-08-17 |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100376273C (en) * | 2005-08-05 | 2008-03-26 | 贵州地道药业有限公司 | Soft capsule for treating heart palpitation and its preparation method |
CN102319375A (en) * | 2011-08-15 | 2012-01-18 | 江苏苏南药业实业有限公司 | Medicine for treating cervical spondylopathy and preparation method thereof |
CN102784308A (en) * | 2012-07-24 | 2012-11-21 | 马千里 | Chinese medicine composition for treating neurasthenia |
CN102824550A (en) * | 2012-09-14 | 2012-12-19 | 昭通市骅成制药有限公司 | Method for preparing compound gastrodia elata preparation |
CN105343794A (en) * | 2015-12-13 | 2016-02-24 | 徐士魁 | Drug for treating neurasthenia and preparation method thereof |
CN106333035A (en) * | 2016-10-13 | 2017-01-18 | 赤水市亿成生物科技有限公司 | Gastrodia elata brain-strengthening health care tea |
CN108653589A (en) * | 2018-07-26 | 2018-10-16 | 灏瑰缓 | It is a kind of to treat neurasthenic drug and preparation method thereof |
CN114767791A (en) * | 2022-05-06 | 2022-07-22 | 江苏省中医院 | Traditional Chinese medicine composition for treating hypertensive sleep disorder and preparation method thereof |
-
2003
- 2003-07-30 CN CN 03132231 patent/CN1214811C/en not_active Expired - Fee Related
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100376273C (en) * | 2005-08-05 | 2008-03-26 | 贵州地道药业有限公司 | Soft capsule for treating heart palpitation and its preparation method |
CN102319375A (en) * | 2011-08-15 | 2012-01-18 | 江苏苏南药业实业有限公司 | Medicine for treating cervical spondylopathy and preparation method thereof |
CN102319375B (en) * | 2011-08-15 | 2013-06-12 | 江苏苏南药业实业有限公司 | Medicine for treating cervical spondylopathy and preparation method thereof |
CN102784308A (en) * | 2012-07-24 | 2012-11-21 | 马千里 | Chinese medicine composition for treating neurasthenia |
CN102824550A (en) * | 2012-09-14 | 2012-12-19 | 昭通市骅成制药有限公司 | Method for preparing compound gastrodia elata preparation |
CN105343794A (en) * | 2015-12-13 | 2016-02-24 | 徐士魁 | Drug for treating neurasthenia and preparation method thereof |
CN106333035A (en) * | 2016-10-13 | 2017-01-18 | 赤水市亿成生物科技有限公司 | Gastrodia elata brain-strengthening health care tea |
CN108653589A (en) * | 2018-07-26 | 2018-10-16 | 灏瑰缓 | It is a kind of to treat neurasthenic drug and preparation method thereof |
CN114767791A (en) * | 2022-05-06 | 2022-07-22 | 江苏省中医院 | Traditional Chinese medicine composition for treating hypertensive sleep disorder and preparation method thereof |
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