CN1480160A - Single spray agent of Chinese herbal medicine used as treament and first aid for cardiovascular disease as well as its preparing method - Google Patents
Single spray agent of Chinese herbal medicine used as treament and first aid for cardiovascular disease as well as its preparing method Download PDFInfo
- Publication number
- CN1480160A CN1480160A CNA021293570A CN02129357A CN1480160A CN 1480160 A CN1480160 A CN 1480160A CN A021293570 A CNA021293570 A CN A021293570A CN 02129357 A CN02129357 A CN 02129357A CN 1480160 A CN1480160 A CN 1480160A
- Authority
- CN
- China
- Prior art keywords
- rhizoma chuanxiong
- total alkali
- aid
- spray
- distilled water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of spray for the treating and first aid of cardiovascular diseases is prepared from Chuan-xiong rhizome through slicing, immersing in alcohol, extracting to obtain powder, supercritical CO2 extracting to obtain common cnidium base, mixing it with distilled water, and nano emulsifying. Its advantages are high curative effect, no toxic by-effect and convenient application.
Description
Technical field
The invention belongs to Chinese medicine preparation and preparation method thereof, single medicinal material spray of particularly a kind for the treatment of cardiovascular disease and first aid and preparation method thereof.
Background technology
Cardiovascular disease mainly is meant coronary heart disease, and the most basic symptom is angina pectoris.The herbal species of known treatment cardiovascular disease is a lot, and kind commonly used has " SUXIAO JIUXIN WAN ", " Radix Salviae Miltiorrhizae drop pill " and " FUFANG DANSHEN PIAN " or the like.Along with the Chinese medicine development of modernization, the Chinese medicine preparation capable of permeating skin of treatment cardiovascular disease, for example being mainly used in the Chinese medicine compound " oral film " of first aid and " the skin pad pasting " of treatment usefulness also has significant progress.
How many Chinese medicine ingredients of above-mentioned oral formulations or preparation capable of permeating skin differs, but main, the most basic main in other words flavor medicine has only Rhizoma Chuanxiong.The outstanding drug action of Rhizoma Chuanxiong has been discussed detailed in the modern Chinese medicine pharmaceutical research, and wherein most important effect is coronary artery dilating, coronary blood flow increasing, reduction myocardium keto consumption, cerebral blood flow increasing amount, improve the rheology of arteriole blood flow, accelerate the microcirculation blood flow flow velocity impels blood capillary open.The above-mentioned outstanding drug action of Rhizoma Chuanxiong all has zoopery result widely to be the basis, and the modern pharmacology theoretical research thinks that the main component ligustrazine in the extract Rhizoma Chuanxiong total alkali of Rhizoma Chuanxiong is new calcium antagonist and thrombolytics, it can reduce the concentration of free calcium in the vascular smooth muscle cytoplasm on molecular level, make calcium ion with
Troponin separates, and causes actin and myosinBetween high chain separate, make vascular smooth muscle relaxation and cause vasodilation.Ligustrazine can also significantly increase the dissolution rate of red thrombus, and weaken the white thrombus growth trend to a certain extent, will inevitably produce the increase of bore, velocity of blood flow and the flow of tremulous pulse and arteriole blood vessel, obviously improve hemorheological property, blood viscosity is also reduced simultaneously, simultaneously other blood circulation of health are also had positive role.
Other Chinese medicine ingredients of above-mentioned oral formulations or preparation capable of permeating skin, for example the Borneolum Syntheticum in the SUXIAO JIUXIN WAN, Radix Et Caulis Acanthopanacis Senticosi, Radix Salviae Miltiorrhizae, Flos Carthami etc. all do not have the correlational study report can prove that itself and Rhizoma Chuanxiong have equivalent effect and effect.Special needs to be pointed out is Borneolum Syntheticum, have one's ideas straightened out because of it is penetrating, the effect of clearing away heat to alleviate pain almost is indispensable accessory drugs in the preparation of SUXIAO JIUXIN WAN and considerable part, but there are many countries that Borneolum Syntheticum is classified as in the world and prohibit the clothes composition, its reason is that side effect is obvious, even has the possibility that causes pathological changes.
It is clinical that the nitroglycerin of Western medicine has its spray to be used for, and its onset speed and degree easy to use all are better than its tablet, and patient's generally reflection can fully confirm this result.
Comprehensive above analysis can draw as drawing a conclusion, and utilizes the original drug action advantage of Rhizoma Chuanxiong or ligustrazine, and developing with Western medicine nitroglycerin spray Chinese medicine spray roughly the same is to meet the Chinese medicine state basic policy and fill up this barren important act.
Summary of the invention
The present invention is the technical problem that lacks the Chinese medicine spray in order to solve in the field of Chinese medicines for the treatment of cardiovascular disease and first aid, and discloses single medicinal material spray of a kind of onset speed treating cardiovascular disease fast and easy to use and first aid and preparation method thereof.
Chinese medicine spray of the present invention is made up of following component and Wt%:
Rhizoma Chuanxiong extract Rhizoma Chuanxiong total alkali 0.25-0.6,
Distilled water all the other.
Chinese medicine spray its preparation method of the present invention is made up of following steps:
1, be soaked in slice thickness 1-5mm ethanol 8-48 hour after the Rhizoma Chuanxiong section.
2, the alcohol extraction method gets Powdered Rhizoma Chuanxiong crude extract.
3, the Rhizoma Chuanxiong crude extract is through CO
2Supercritical extraction gets brown oily Rhizoma Chuanxiong total alkali, 55 ℃ ± 5 ℃ of extraction temperature, pressure 5-8Mpa, time 0.5-1 hour.
4, the Rhizoma Chuanxiong total alkali that adds percentage by weight up to specification in the distilled water of metering gets the mixed liquor of Rhizoma Chuanxiong total alkali and distilled water.
5, with mixed liquor through the emulsifying of nanometer equipment process Rhizoma Chuanxiong total alkali emulsion, Rhizoma Chuanxiong total alkali mean particle dia is in the 40-60nm scope.
6, according to dosage with the common process packing.
Beneficial effect of the present invention and advantage are:
This spray only contains the single medicinal material Rhizoma Chuanxiong extract, and known effective ingredient ligustrazine can fully guarantee drug effect and not contain the composition of the toxic side effect in any other prescription in the extract.Rhizoma Chuanxiong extract has strong volatilization abnormal smells from the patient, especially is fit to do spray and uses.The Rhizoma Chuanxiong extract content range can adapt to weight disease patient's different requirements in this spray.
Below with every bottle of spray dosage 14g, contain Rhizoma Chuanxiong extract 42mg (0.3%), whenever spray this spray that contains Rhizoma Chuanxiong extract 0.21mg for 1 time, respectively with SUXIAO JIUXIN WAN (each oral 10) and every bottle of spray dosage 14g, contain nitroglycerin 100mg (0.71%), the clinical effectiveness tabulation of date that whenever sprays the Nitrolingual that contains nitroglycerin 0.5mg for 1 time compares, and gives prominence to effect so that this spray is described.Above-mentioned 3 kinds of medicines are also used in table central vessel disease patient grouping respectively, and 50 of every group of patients all are diagnosed as coronary heart disease and are in the angina pectoris period happening with increasing frequency, and sex and age bracket are divided equally, patient's collection of data time span 18 months.
Table 1 comparison sheet action time
| The time group | Average onset time | Mean up time | The major side effects reaction |
| The nitroglycerin group | 30 seconds | 15 minutes | The headache head rises |
| This spray group | 33 seconds | 30 minutes | Slight the giddy of rising |
| SUXIAO JIUXIN WAN | 5.73 minute | 30 minutes | Stomach discomfort |
Table 2 effect comparison sheet
| The effect category group | Effect is (number) significantly | Effect general (number) | Total effective rate (%) |
| The nitroglycerin group | ????28 | ????18 | ????92 |
| This spray group | ????31 | ????17 | ????96 |
| SUXIAO JIUXIN WAN | ????17 | ????29 | ????96 |
In the table 1 in " average onset time " and the table 2 standard of " effect is remarkable " foundation be the electrocardiogram parameter mainly, suitably in conjunction with patient's readme.
By as can be seen above, the average onset time and the result of use of this spray are same as Nitrolingual substantially, and are better than SUXIAO JIUXIN WAN.Mean up time and total effective rate are same as SUXIAO JIUXIN WAN, and are better than Nitrolingual.Especially the reaction of the major side effects of this spray all is better than other two kinds relatively medicines.
This spray meets country medicine management general bureau became Chinese medicine spray type first aid medicine at 3 minutes with interior requirement about this quasi drugs average onset time, sprayed use by the oral cavity simultaneously, easy to use than other form of Chinese drug.
The preparation method advanced person of this spray, its quality of item is stable, high conformity, and the layering and precipitating phenomenon does not appear in long-time storage.
The specific embodiment
Embodiment: the Rhizoma Chuanxiong section of the screening of learning from else's experience, thickness 2mm was soaked in ethanol 24 hours after the section, make the abundant stripping of effective ingredient in the lamellar Rhizoma Chuanxiong.Once can get Powdered Rhizoma Chuanxiong crude extract with the alcohol extraction method, way be utilize 100L concentrate unit and 15KW steam generator routinely technology extract, yield generally can reach 30-40%.
With the Rhizoma Chuanxiong crude extract through CO
2Supercritical extraction continue to extract brown oily Rhizoma Chuanxiong total alkali, 55 ℃ of extraction temperature, pressure 6Mpa, 50 minutes time.The Powdered Rhizoma Chuanxiong crude extract of 1000g can get 15-25g Rhizoma Chuanxiong total alkali generally speaking.
Account for 0.3% by the Rhizoma Chuanxiong total alkali, distilled water accounts for the mixed liquor of 99.7% percentage by weight preparation Rhizoma Chuanxiong total alkali and distilled water, afterwards with mixed liquor through the emulsifying of nanometer equipment process Rhizoma Chuanxiong total alkali emulsion, Rhizoma Chuanxiong total alkali mean particle dia is in the 40-60nm scope.Because Rhizoma Chuanxiong total alkali and distilled water particle mass are almost equal, this spray deposited phenomenon can not occur.Rhizoma Chuanxiong total alkali emulsion is pressed the packing of every bottle of 14g dosage.
Claims (2)
1, the single medicinal material spray for the treatment of cardiovascular disease and first aid is characterized in that being made up of following component and Wt%:
Rhizoma Chuanxiong extract Rhizoma Chuanxiong total alkali 0.25-0.6,
Distilled water all the other.
2, single medicinal material spray according to claim 1 is characterized in that its preparation method is made up of following steps:
(1) was soaked in slice thickness 1-5mm ethanol 8-48 hour after the Rhizoma Chuanxiong section.
(2) the alcohol extraction method gets Powdered Rhizoma Chuanxiong crude extract.
(3) the Rhizoma Chuanxiong crude extract is through CO
2Supercritical extraction gets brown oily Rhizoma Chuanxiong total alkali, 55 ℃ ± 5 ℃ of extraction temperature, pressure 5-8Mpa, time 0.5-1 hour.
(4) the Rhizoma Chuanxiong total alkali that adds percentage by weight up to specification in the distilled water of metering gets the mixed liquor of Rhizoma Chuanxiong total alkali and distilled water.
(5) with mixed liquor through the emulsifying of nanometer equipment process Rhizoma Chuanxiong total alkali emulsion, Rhizoma Chuanxiong total alkali mean particle dia is in the 40-60nm scope.
(6) according to dosage with the common process packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021293570A CN1480160A (en) | 2002-09-06 | 2002-09-06 | Single spray agent of Chinese herbal medicine used as treament and first aid for cardiovascular disease as well as its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021293570A CN1480160A (en) | 2002-09-06 | 2002-09-06 | Single spray agent of Chinese herbal medicine used as treament and first aid for cardiovascular disease as well as its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1480160A true CN1480160A (en) | 2004-03-10 |
Family
ID=34144127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA021293570A Pending CN1480160A (en) | 2002-09-06 | 2002-09-06 | Single spray agent of Chinese herbal medicine used as treament and first aid for cardiovascular disease as well as its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1480160A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019200768A1 (en) * | 2018-04-17 | 2019-10-24 | 贾洪章 | Traditional chinese medicine composition for treating cardiovascular and cerebrovascular disease, preparation method therefor and use thereof |
-
2002
- 2002-09-06 CN CNA021293570A patent/CN1480160A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019200768A1 (en) * | 2018-04-17 | 2019-10-24 | 贾洪章 | Traditional chinese medicine composition for treating cardiovascular and cerebrovascular disease, preparation method therefor and use thereof |
| US11369653B2 (en) | 2018-04-17 | 2022-06-28 | Hongzhang Jia | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular disease, preparation method therefor and use thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1994451B (en) | Chinese medicinal composition for treating depression, its preparation method and application | |
| CN1868532A (en) | Medicine for treating hypertension | |
| CN1895620A (en) | Chinese-medicinal composition for treating coronary heart disease | |
| CN1943618A (en) | Red sage root effective part standard extract and its preparing method and use | |
| CN100379436C (en) | Pharmaceutical composition for treating depression, preparation method and application thereof | |
| CN101953918B (en) | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases | |
| CN109820932A (en) | A kind of Chinese medicine standard decoction for preventing and treating senile dementia | |
| CN1686294A (en) | Medicinal composition for treating coronary heart disease stenocardia | |
| CN102357208B (en) | Traditional Chinese medicine composition for treating diabetes, hyperglycemia, hypertension, and hyperlipidemia | |
| CN101279034B (en) | Combined Chinese medicament for curing diabetic with combined internal and external therapies and preparation thereof | |
| CN1480160A (en) | Single spray agent of Chinese herbal medicine used as treament and first aid for cardiovascular disease as well as its preparing method | |
| CN1682837A (en) | Medicine for regulating blood fat and its preparing method | |
| CN115089655A (en) | Traditional Chinese medicine composition for treating Alzheimer's disease, extract, preparation method and application | |
| CN1194724C (en) | Chinese medical preparation for treating coronary disease and angina pectoris and preparation thereof | |
| CN102204956B (en) | Chinese medicinal composition used at stroke recovery period and preparation method thereof | |
| CN101450189A (en) | Medicine for curing angiocardiopathy and cerebrovascular disease and its preparing method | |
| CN101559139A (en) | Prescription of pure traditional Chinese medicine preparation for preventing and curing neurasthenia insomnia and preparation method thereof | |
| CN100464773C (en) | Yixinshu Injecta for retaliation of Qi and pulse and promotion of blood circulation and removing of blood stasis, and preparing method therefor | |
| CN1686198A (en) | Oral administration medicinal preparation prepared using notoginseng, salvia root and erigeron breviscapus extracts | |
| CN111939223A (en) | Traditional Chinese medicine composition with auxiliary blood sugar reduction effect and preparation method thereof | |
| CN1234409C (en) | Combinaton of medication for treating depression and preparation method | |
| CN1250244C (en) | Composition for preventing and treating hyperlipidemia | |
| CN108567753A (en) | All beam dripping pill and its preparation process | |
| CN1257729C (en) | Medicine for treating headache and preparing method thereof | |
| CN1054074C (en) | Compound ginkgo leaf prepn. and its prepn. method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |