CN1462595A - Health care food for regulating immunity, antioxidation and its preparing method - Google Patents
Health care food for regulating immunity, antioxidation and its preparing method Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
A health-care food for regulating immunity and resisting oxidation is prepared from pine needles, ophiopogon root and starch or beta-cyclodextrin through extracting the extract of pine needles or squeezing the pine needle to obtain juice, extracting the active components from ophiopogon root, proportional mixing, and adding starch or beta-cyclodextrin.
Description
Technical field
The present invention relates to a kind of health food, especially relate to a kind of adjusting immunity, oxidation-resisting health-care food and preparation method thereof.
Background technology
Along with people's living standard improves constantly, people's health care consciousness strengthens day by day, and people often take some tonic foods and build up health, and delays senility, to reach the purpose that improves the health.At present, pine needle health-care food is based on oral liquid, capsule, be generally delay senility, hypolipemic function, other health care such as immunological regulation, antifatigue etc. are not also fully excavated, and prescription is complicated.Be conventional Chinese medicine the tuber of dwarf lilyturf, but the product technology content tuber of dwarf lilyturf in the market is low, and the main effect of its product is that moistening lung is promoted the production of body fluid, replenishing the vital essence and removing heat, and modern pharmacology proof ophiopogonpolysaccharide has antifatigue, anti-anoxic, immunological enhancement.Therefore, the pine needle and the tuber of dwarf lilyturf to be that the health food of primary raw material has the excellent development prospect, demand urgently developing have reasonable scientific formula, unique production process, normalized quality control standard and give full play to the new product of its health care.
Summary of the invention
It is a kind of the natural pine needle and the tuber of dwarf lilyturf to be the raw material adjusting immunity of making, oxidation-resisting health-care food and preparation method thereof that the object of the invention is to provide.
Adjusting of the present invention is immune, oxidation-resisting health-care food, it is characterized in that comprising the proportioning (weight ratio) of following component and each component:
Extract from pine needles or bright pine needle (squeezing juice) 0.5～5
Ophiopogon japonicus extract 1～3
Also can contain in its component of the invention described above health food is 0.5～5.0 starch or beta-schardinger dextrin-or other auxiliary material by weight.
The optimum ratio (weight ratio) of contained each component of the invention described above health food is:
Extract from pine needles or bright pine needle (squeezing juice) 1～3
Extract 1～2 the tuber of dwarf lilyturf
Starch or beta-schardinger dextrin-2～3
The invention described above health food the best comprises the proportioning (weight ratio) of following component and each component:
Extract from pine needles 1
Ophiopogon japonicus extract 1
Starch or beta-schardinger dextrin-2
Adjusting immunity of the present invention, oxidation-resisting health-care food, its formulation can be formulation or beverage, the thoat-soothing drops etc. such as powder of tablet, oral liquid, capsule, aseptic packaging.
Adjusting immunity of the present invention, oxidation-resisting health-care food can be by following method preparations, and its step comprises:
(1) pine needle is cut into segment, adds water and directly squeezes into juice or through water or alcohol extracting one to three time, merge extract, concentrates the juice or the extract of gained, dry extract from pine needles; Or directly squeeze into bright pine needle squeezing juice with bright pine needle, and can add water during squeezing, amount of water is 0～10 times (being generally 0.5～6 times) of bright pine needle weight
(2) extract one to three time through water the tuber of dwarf lilyturf, filtrate concentrates, alcohol precipitation, and precipitation is dry, gets ophiopogon japonicus extract;
(3) gained extract from pine needles or bright pine needle squeezing juice and ophiopogon japonicus extract are mixed by required proportioning, add auxiliary material more according to conventional methods, be prepared into required preparation; Used auxiliary material can be starch or beta-schardinger dextrin-, perhaps food or pharmaceutical industries other auxiliary material commonly used.
The described water in step in the said method (1) and (2) extracts can adopt in room temperature or under the ebuillition of heated condition and carries out, and extraction time is at least one to three time, and the number of times increase is not limit; The consumption of water is not for having medicinal material at least, and water consumption is not too much limit.
Step in the said method (1) and (2) described drying can be heating, drying, also can adopt spray-drying.
The used alcohol of alcohol extracting described in the said method or alcohol precipitation is ethanol, can adopt absolute ethyl alcohol or various concentration ethanol; The ultimate density of precipitation with alcohol can be the various concentration of 5%～95% (V/V).
Prove that through animal experiment health food of the present invention has tangible adjusting immunity and antioxidation.
The present invention is a main component with the extract of natural plants pine needle, the tuber of dwarf lilyturf.Pine needle is all on the books in the successive dynasties book on Chinese herbal medicine, put down in writing according to " Chinese medicine voluminous dictionary " " dispel pathogenic wind and remove dampness, desinsection, antipruritic.Control rheumatism impotence numbness, traumatic injury, insomnia, edema, wet sore, mange.And can prevent and treat epidemic meningitis, influenza, hookworm disease." " not Lu " meaning: its " the main air sore that wets, piliation, five viscera settling." Compendium of Material Medica day: " and nontoxic, clothes make us not old for a long time for pine needle, smell hardship, temperature, and the beneficial gas of making light of one's life by commiting suicide cures mainly the rheumatism sore, piliation, and five viscera settling, in keeping, not hungry prolonging life." modern study shows that pine needle contains and enrich bioactive ingredients and nutritional labeling.Contain multiple natural active matters such as profuse OPC in the extract from pine needles, OPC is one of current the strongest antioxidant, and its antioxidation activity is 50 times of vitamin E, ascorbic 20 times, can powerfully remove unnecessary free radical in the body; And the unnecessary free radical that can not remove naturally in the body is harmful to, it causes that the lipid peroxidation product concentration of malondialdehyde increases in the cell, the crosslinked action of MDA and the chain reaction of free radical, can make protein denaturation, enzyme is an inactivation, make hereditary material DNA infringement and variation, these in vivo residual unnecessary free radicals can cause more than 70 kind of disease of health, are the basic reasons of human senility.
Another main component tuber of dwarf lilyturf is a conventional Chinese medicine among the present invention, according to " Chinese medicine voluminous dictionary " record " Yin nourishing and lung moistening, the relieving restlessness that clears away heart-fire, reinforcing stomach reg fluid.Control dryness of the lung dry cough, spit blood, spitting of blood, the lung fistula, lung carbuncle, the consumptive disease dysphoria with smothery sensation is quenched one's thirst, and hinder in pyreticosis Tianjin, dry throat, constipation." " not Lu " meaning; " treat the heavy order Huang of body, rami cardiaci inferiores is full, and the consumptive disease visitor is hot, and dry mouth is thirsty, and preventing or arresting vomiting is told, and more impotence falls, and the reinforcing yin essence benefit is smart, and the Gu Tiaozhong that disappears protects god, decides lung qi, and five viscera settling makes us fertile strong ".Ophiopogonpolysaccharide in the tuber of dwarf lilyturf has antifatigue, anti-anoxic, immunological enhancement.Discover to act on DNA and CAMP/CGMP the tuber of dwarf lilyturf,, especially can improve low immunologic function to regulate immunologic function.By improving the synthetic ratio of nucleic acid, with the generation of immune substances such as enhancing antibody, complement, interferon, lysozyme.
The specific embodiment
Below the invention will be further described by specific embodiment and test example.
Embodiment 1:
Get bright Lignum Pini Nodi pine needle, clean, be cut into the segment of 1cm, take by weighing 500g, add water 5000ml, decoct 2 times, each 0.5 hour, extract was concentrated into 1000ml, is spray dried to powder.
Get the 500g tuber of dwarf lilyturf, clean, be cut into the segment of 1cm, add water 5000ml, decocts 3 times, each 1 hour, filter and be condensed into 500ml, add 95% ethanol and make and contain the alcohol amount and reach 60%, filter precipitation, drying gets ophiopogon japonicus extract.
Take by weighing 3 parts of extract from pine needles by weight, 1 part of ophiopogon japonicus extract, 1 part of starch, mixing, drying is pulverized, and is filled to capsule.
Embodiment 2:
Get bright Lignum Pini Nodi pine needle, clean, be cut into the segment of 1cm, take by weighing 500g, add 75% ethanol 5000ml, decoct 2 times, each 20 minutes, extract was concentrated into 1000ml, is spray dried to powder.
Get the 500g tuber of dwarf lilyturf, clean, be cut into the segment of 1cm, add water 5000ml, decocts 3 times, each 1 hour, filter and be condensed into 500ml, add 95% ethanol and make and contain the alcohol amount and reach 70%, filter precipitation, drying gets ophiopogon japonicus extract.
Take by weighing 2 parts of extract from pine needles by weight, 1 part of ophiopogon japonicus extract, 0.8 part of starch, mixing, drying is pulverized, and is filled to capsule.
Embodiment 3:
Get bright Lignum Pini Nodi pine needle, clean, be cut into the segment of 1cm, take by weighing 500g, add water 1000ml, press juice, residue is washed with 500ml, merges pine needle juice.It is 1.1-1.2 that extract is concentrated into relative density, is spray dried to powder.
Get the 500g tuber of dwarf lilyturf, clean, be cut into the segment of 1cm, add water 5000ml, decocts 3 times, each 1 hour, filter and be condensed into 500ml, add 95% ethanol and make and contain the alcohol amount and reach 80%, filter precipitation, drying gets ophiopogon japonicus extract.
Take by weighing 1 part of extract from pine needles by weight, 1 part of ophiopogon japonicus extract, 2.5 parts of starch, mixing, drying is pulverized, and is filled to capsule.
Embodiment 4:
Get bright Lignum Pini Nodi pine needle, clean, be cut into the segment of 1cm, take by weighing 500g, add water 1000ml, press juice, residue is washed with 500ml, merges pine needle juice.It is 1.1-1.2 that extract is concentrated into relative density.
Get the 500g tuber of dwarf lilyturf, clean, be cut into the segment of 1cm, add water 5000ml, decocts 3 times, each 1 hour, filter and be condensed into 500ml, add 95% ethanol and make and contain the alcohol amount and reach 80%, filter precipitation, drying gets ophiopogon japonicus extract.
Measure 3 parts of extract from pine needles concentrates by weight, 1 part of ophiopogon japonicus extract, 2.5 parts of starch, fully stirring and evenly mixing is spray dried to powder, is filled to capsule.
The test example:
The animal experiment of adjusting immunity of the present invention, oxidation-resisting health-care food capsule being done by " the health food function assessment assessment process and the method for inspection " by Zhongshan University modern Chinese herbal medicine quality research development centre is reported as follows:
1. every day the inbred mouse oral administration is given basic, normal, high three dosage groups of 1 times of recommended amounts, 3 times of recommended amounts and 10 times of recommended amounts that capsule of the present invention is equivalent to people's recommended amounts respectively, establish a control group in addition, feeding carried out clearance test of mouse carbon and dinitrofluorobenzene inducing mouse DTH test after 30 days altogether.The result obtains: 1. represent that with phagocytic index the carbon of mouse cleans up ability, analyze by statistics that the phagocytic index of three dosage groups is significantly higher than the phagocytic index of control group.2. the degree of representing DHT with the difference of mouse left and right sides ear weight is analyzed by statistics, and the difference of dosage group is significantly higher than the difference of control group.Above-mentioned animal test results shows that health-care edible capsule of the present invention has the ability of the immunity regulated.
2. every day Drosophila melanogaster oral administration capsule of the present invention respectively is equivalent to basic, normal, high three dosage groups of 1 times of recommended amounts of people's recommended amounts, 3 times of recommended amounts and 10 times of recommended amounts, establishes an aged group of contrast in addition, stop to life span of drosophila melanogaster.Respectively give basic, normal, high three the dosage groups of 1 times recommended amounts, 3 times recommended amounts and 10 times recommended amounts that of the present invention capsule be equivalent to people recommended amounts to 18 months rat orals clothes every day, establishes a control group in addition, totally 45 days.The result obtains: 1. dosage group and control group are relatively tried half death, average life span and the maximum life span of fruit bat and are analyzed by statistics, and difference has conspicuousness (P＜0.05).2. the dosage group compares with the aged group of contrast, and the SOD in the rat blood serum (superoxide dismutase) vigor raises and analyzes by statistics, and difference has conspicuousness (P＜0.05).Above-mentioned animal test results shows that capsule of the present invention has antioxidation.
Claims (10)
1. regulate immunity, oxidation-resisting health-care food for one kind, it is characterized in that comprising following component and each component proportioning by weight:
Extract from pine needles or bright pine needle squeezing juice 0.5～5
Ophiopogon japonicus extract 1～3
2. according to the described health food of claim 1, it is characterized in that also containing in its component starch or beta-schardinger dextrin-by weight promising 0.5～5.0.
3. according to the described health food of claim 2, it is characterized in that the proportioning of contained each component is by weight:
Extract from pine needles or bright pine needle squeezing juice 1～3
Extract 1～2 the tuber of dwarf lilyturf
Starch or beta-schardinger dextrin-2～3
4. according to the described health food of claim 2, it is characterized in that contained each component and proportioning thereof are by weight:
Extract from pine needles 1
Ophiopogon japonicus extract 1
Starch or beta-schardinger dextrin-2
5. according to claim 1,2,3 or 4 described health foods is characterized in that its formulation is powder, beverage or the thoat-soothing drops of tablet, oral liquid, capsule, aseptic packaging.
6. claim 1, the preparation method of 2,3 or 4 described health foods, its step comprises:
(1) pine needle is cut into segment, adds water and directly squeezes into juice or through water or alcohol extracting one to three time, merge extract, concentrates the juice or the extract of gained, dry extract from pine needles; Or directly squeeze into juice with bright pine needle;
(2) extract one to three time through water the tuber of dwarf lilyturf, filtrate concentrates, alcohol precipitation, and precipitation is dry, gets ophiopogon japonicus extract;
(3) gained extract from pine needles or bright pine needle squeezing juice and ophiopogon japonicus extract are mixed by required proportioning, add starch or beta-schardinger dextrin-more according to conventional methods, or add other auxiliary material, be prepared into required preparation.
7. in accordance with the method for claim 6, it is characterized in that it is to carry out in room temperature or under the ebuillition of heated condition that described water extracts, extraction time is one to three time, or more than three times; The consumption of water is not for having medicinal material at least.
8. according to claim 6 or 7 described methods, it is characterized in that described drying is heating, drying or spray-drying.
9. according to claim 6 or 7 described methods, it is characterized in that the used alcohol of described alcohol extracting is absolute ethyl alcohol or various concentration ethanol.
10. according to claim 6 or 7 described methods, it is characterized in that the used alcohol of described alcohol precipitation is absolute ethyl alcohol or various concentration ethanol; The ultimate density of precipitation with alcohol is 5%～95%V/V.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031269923A CN1320865C (en) | 2003-06-26 | 2003-06-26 | Health care food for regulating immunity, antioxidation and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031269923A CN1320865C (en) | 2003-06-26 | 2003-06-26 | Health care food for regulating immunity, antioxidation and its preparing method |
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| CN1462595A true CN1462595A (en) | 2003-12-24 |
| CN1320865C CN1320865C (en) | 2007-06-13 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102742832A (en) * | 2011-04-18 | 2012-10-24 | 北京天植百桂生物技术有限公司 | Dietetic therapy product for protecting joint and preparation method thereof |
| CN109380724A (en) * | 2018-12-10 | 2019-02-26 | 凃玉英 | A kind of alcohol-free red wine capsule and preparation method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1033212C (en) * | 1993-01-04 | 1996-11-06 | 北京师范大学 | Pine needle hypoglycemic oral liquid |
| CN1099627A (en) * | 1993-08-30 | 1995-03-08 | 江苏省肿瘤防治研究所 | Method for preparing anti-cancer and supporting health energy medicine using pine needle |
-
2003
- 2003-06-26 CN CNB031269923A patent/CN1320865C/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102742832A (en) * | 2011-04-18 | 2012-10-24 | 北京天植百桂生物技术有限公司 | Dietetic therapy product for protecting joint and preparation method thereof |
| CN102742832B (en) * | 2011-04-18 | 2015-03-11 | 北京天植百桂生物技术有限公司 | Dietetic therapy product for protecting joint and preparation method thereof |
| CN109380724A (en) * | 2018-12-10 | 2019-02-26 | 凃玉英 | A kind of alcohol-free red wine capsule and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1320865C (en) | 2007-06-13 |
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