CN1454526A - Functional health-care beverage for helping to sobering one - Google Patents
Functional health-care beverage for helping to sobering one Download PDFInfo
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- CN1454526A CN1454526A CN 03108564 CN03108564A CN1454526A CN 1454526 A CN1454526 A CN 1454526A CN 03108564 CN03108564 CN 03108564 CN 03108564 A CN03108564 A CN 03108564A CN 1454526 A CN1454526 A CN 1454526A
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Abstract
The invention refers to health drink for sobering, adopting the medicinal and edible natural raw materials such as the liana tea, the fingered citron, the red orange, the root of kudzu vine and the liquorice to extract and add the components such as the taurine with the liver protecting and antialcoholic functions, concentrated fresh organic juice, lemon juice and honey and then refining to make the health drink. It has characters of quick assimilating, strong antialcoholic function, good taste, etc.
Description
Technical field:
The present invention relates to field of health care food.
Background technology:
Since ancient times, to spill be one of colourful life content of people to drink.Especially along with the China market expanding economy, the increasing of the increased and social dinner party of business activity, heavy drinking causes uncomfortable and to influence the healthy situation of alcohol user of common occurrence.Therefore market demand has the health product of antialcoholism function, with hardship of separating insobriety with protect after drinking healthy of people.Advantages such as compare with existing disintoxicating product, the present invention has mouthfeel good, and is functional strong, and it is rapid to play a role will provide comparatively ideal health beverage able to dispel for consumer.
Summary of the invention:
The Ampelopsis grossedentata of medicine-food two-purpose, Fructus Citri Sarcodactylis, orange, Radix Puerariae, Radix Glycyrrhizae powder are broken into coarse powder, add the water supersound extraction, extracting solution suitably is concentrated into certain volume, adding hardening agent taurine and correctives concentrated orange juice, Fructus Citri Limoniae juice and Mel, mixing fine straining forms, every bottle of 100ml, its prescription is: Ampelopsis grossedentata, Fructus Citri Sarcodactylis, orange, Radix Puerariae, Radix Glycyrrhizae each 0.5～15 part (W/V); 0.1～5 part of taurine (W/V); 2～20 parts of concentrated orange juices (W/V); 5～60 parts of Mel (W/V); 0～60 part of drinking water (W/V).
But the present invention has selected the Chinese medicine of tradition medicine-food two-purpose for use, and it is good to be mixed with a kind of mouthfeel, effect rapidly, the antialcoholism function health beverage, to satisfy the demand of people of drinking to market.
The step that the object of the invention realizes:
One, the method for screening experiment is as follows:
Get 90 of NIH kind mices, ♀ ♂ half and half tests and begins to stop last evening to supply water for food, is divided into 9 groups at random, and 10 every group, and weigh respectively, numbering, body weight is all within 20g ± 2g.If 0 group is the blank group, l → 8 group are test group.Begin 0 group of normal saline that gives 0.3ml/10g, 1 → 8 group all gives corresponding test solution by same dose, and the concentration of its test solution is 20%, as the Fructus Citri Sarcodactylis 20g of Fructus Citri Sarcodactylis test solution system, 2 each 45min of water supersound extraction, extracting solution merge to filter, and filtrate is concentrated into 100ml.The ordering of 1 → 8 knob is: 1, Ampelopsis grossedentata; 2, Niuganguo; 3, Fructus Citri Sarcodactylis; 4, Fructus Citri tangerinae is red; 5, Radix Puerariae; 6, Rhizoma Imperatae; 7, SEMEN COICIS; 8, Radix Glycyrrhizae.0 → 8 group finish with order and according to the dosage of regulation irritate stomach after, enrollment time, behind the 30min, the Guilin three-flower wine (53 °) that gives 0.22me/10g is equally in order irritated stomach, observe and each group of record in the mice righting response disappear that the % of (drunk) leads and the time (press 60min greater than 60min calculates) of generation, and add up 24h and respectively organize mortality of mice.
The result of table 1 screening experiment (x=x ± s n=10)
Annotate: * and 0 blank comparison P＜0.05 two, according to the result of above-mentioned screening test, further compare with prescription and test, its method is as follows: experiment is established 6 groups altogether, 10 of every group of NIH kind mices, the O group is the blank group, 1-5 group is test group, and the test solution that they irritate stomach is respectively: 1 group of 2 of drunk-sobering tablet that are Guangdong company produces adds water and grinds well into 21ml and make test solution, and 2 groups is 2% (W/V) taurine solution; 3 groups is 20% (W/V) water extract for using by Ampelopsis grossedentata, Fructus Citri Sarcodactylis, orange, Radix Puerariae, the total crude drug amount of Radix Glycyrrhizae; 4 groups with concentrated orange juice, Fructus Citri Limoniae juice each 10%, the mamoncillo juice of Mel 20%, drinking water 60% (W/V) mix homogeneously; The water extract that 5 groups of total crude drug amounts by each Ampelopsis grossedentata of 4%, Fructus Citri Sarcodactylis, orange, Radix Puerariae, Radix Glycyrrhizae are 20% (W/V) add 0.8% (W/V) taurine and concentrated orange juice, Fructus Citri Limoniae juice each 10%, Mel 20% is formulated.The same screening test of method that contrast and prescription test of relieving the effect of alcohol.Table 2 result (x=x ± s n=10) that contrast and prescription are tested of relieving the effect of alcohol
Annotate: compare with O group blank
*P＜0.05
| Group | ????0 | ????1 | ???2 | ???3 | ???4 | ???5 | ???6 | ????7 | ???8 |
| The drunk rate % mortality rate of incubation period/min % | ????6.7±9.2 ????100 ????90 | ????36.5±17.1 *????50 *????20 * | ???6.9±11.6 ???90 ???80 | ???31.5±13.7 *???70 *???40 * | ???28.5±17.2 *???70 *???40 * | ???25.4±15.6 *???60 *???30 *： | ???9.2±8.5 ???90 ???70 | ????7.8±2.2 ????90 ????70 | ???17.7±10.6 *???60 *???30 * |
| Group | 0 | ?1 | ?2 | 3 | 4 | 5 |
| Incubation period/min | 7.9±7.3 | ?10.1±18.7 | ?18.4±15.3 * | 20.2±8.8 * | 28.5±8.9 * | 53.2±18.1 ** |
| Drunk rate % | 100 | ?100 | ?100 | 50 * | 70u | 20 ** |
| Mortality rate % | 90 | ?60 * | ?40 * | 20 * | 30 * | 0 ** |
Compare with other each groups
*P＜0.05
Experimental results show that from above: the function that the drunk-sobering tablet of (1) Guangdong company has the drunk mice of certain alleviation to poison.(2) 2 groups, 3 groups, 4 groups all have and alleviate drunk mice poisoning function preferably.The antialcoholism action of (3) 5 groups of test solutions is the most remarkable, and relatively there were significant differences with other each group, illustrates that the composition of forming three parts of 5 groups of prescriptions by 2,3,4 groups component has good collaborative antialcoholism action.
Three, mice body inner blood determining concentration of alcohol test
Assay method: get 30 of mices (NIH kind), ♀ ♂ half and half, be divided into 3 groups at random, I group # 1-10 number, for gavage normal saline group (N.S+N.S group) merely, the II group # is 11-20 number, for normal saline with wine group (N.S+ wine group), III group # 21-30 number, for the health functional beverage that relieves the effect of alcohol with wine group (beverage+wine group), test last late fasting and prohibit water.Beginning 1-20 number is that the I group is irritated stomach normal saline 0.3ml/10g with the II group, III group 21-30 mice is irritated stomach with the alcohol-decomposing beverage of Isodose, the I group is still irritated stomach normal saline 0.2mg/10g behind the 30min, II group and III group are all irritated stomach Chinese liquor (53 °) 0.2ml/10g, behind 30min, get blood again, the blood of mice concentration of alcohol in the gas chromatography determination blood by the numbering eye socket.The antialcoholism function health beverage of its III group is identical with in the above-mentioned contrast prescription test 5 groups.
The mensuration of ethanol in blood concentration:
(1) sample preparation
1, prepare to draw whole blood 0.2ml to be measured, interior mark liquid (containing normal propyl alcohol 0.8mg/ml) 0.30ml seals in 10ml head space bottle.
2, ethanol standard curve making.Blank blood 0.20ml, interior mark liquid (containing normal propyl alcohol 0.8mg/ml) 0.30ml add ethanol 0.2,0.4,1.0,2.0,3.0,4.0,5.0,7.0,8.0,9.0,10.0ul respectively in 10ml head space bottle, seal.Comparison ethanol addition (ul) the production standard curve of ethanol peak area and normal propyl alcohol peak area.The result is a straight line by initial point, and linear relationship is good, and its linear equation is Y=2.199X; R=0.9995.
(2) instrument and analysis condition
The HS19395A/5890II/FID/3396 of instrument Hewlett-Packard integrator, gas phase spectral condition: sample introduction product temperature: 200 ℃; Detector temperature: 300 ℃; Furnace temperature: 80 ℃; Chromatographic column: HP-FFAP25m * 0.32mm * 0.17um; Stigma is pressed: 8Psi; Shunting outlet: 30ml/min; Tail blows: 20ml/min; Air:44Psi; H2:30Psi; Input mode: split sampling head space instrument condition: oily melting temperatur: 80 ℃; Pipe/valve temperature: 85 ℃; Sample equilibration time: 10min; N2 flow: 20ml/min; Tail blows: 15ml/min; Input mode: pressurization 10s; Emptying: 2s; Sample introduction 60s.
(3) calculate
Utilize blank blood to add the linear equation calculating white mice blood concentration of alcohol that ethanol is made.Linear equation is Y=2.199X; R=0.9995
White mice blood concentration of alcohol
The white mice blood of numbering 1-10 number does not detect alcohol.
| Numbering | 11 | ?12 | ?13 | ?14 | ?15 | ?16 | ?17 | ?18 | ?19 | ?20 |
| A ethanol/A normal propyl alcohol | 7.034 | ?6.470 | ?5.999 | ?5.198 | ?5.659 | ?7.846 | ?6.388 | ?7.095 | ?6.953 | ?4.788 |
| Ethanol absolute magnitude (ul) | 3.199 | ?2.942 | ?2.158 | ?2.364 | ?2.573 | ?3.568 | ?2.905 | ?3.226 | ?3.162 | ?2.173 |
| Concentration (mg/ml) | 12.65 | ?11.64 | ?10.79 | ?9.349 | ?10.18 | ?14.11 | ?11.49 | ?12.76 | ?12.51 | ?8.594 |
11-20 number concentration of alcohol is between 8.594-12.65mg/ml, and meansigma methods is 11.41mg/ml
| Numbering | 21 | ?22 | ?23 | ?24 | ?25 | ?26 | ?27 | ?28 | ?29 | ?30 |
| A ethanol/A normal propyl alcohol | 4.893 | ?5.239 | ?2.249 | ?2.762 | ?5.444 | ?3.067 | ?2.699 | ?3.893 | ?2.326 | ?2.063 |
| Ethanol absolute magnitude (ul) | 2.225 | ?2.382 | ?1.023 | ?1.256 | ?2.476 | ?1.395 | ?1.227 | ?1.770 | ?1.058 | ?0.938 |
| Concentration (mg/ml) | 8.800 | ?9.423 | ?4.045 | ?4.968 | ?9.791 | ?5.516 | ?4.854 | ?7.002 | ?4.183 | ?3.710 |
20-30 number concentration of alcohol is between 3.710-9.791mg/ml, and meansigma methods is 6.299mg/ml.
Measurement result: II group (11-20 number) compares with III group (21-30 number), and there is highly significant difference P＜0.001.Can further prove the beverage of this prescription, definite antialcoholism function is arranged.
Antialcoholism function health beverage of the present invention has comprehensive effect that mouthfeel is good, effect rapid, effect is stronger.
The specific embodiment: (1) gets Ampelopsis grossedentata, Fructus Citri Sarcodactylis, orange, Radix Puerariae, each 30g of Radix Glycyrrhizae; mixed powder is broken into coarse powder; the an amount of supersound extraction of water 2 times; merge extractive liquid,, be condensed into 600ml; take advantage of heat to add taurine 5g stirring and dissolving; add concentrated orange juice, each 100ml of Fructus Citri Limoniae juice and Mel 200ml stir evenly, fine straining, packing sterilization.
(2) get Fructus Citri Sarcodactylis, orange, Radix Glycyrrhizae, each 60g of Ampelopsis grossedentata.An amount of supersound extraction of water 2 times, merge extractive liquid, filters, and filtrate is concentrated into 600ml, places and filters heavy filter, filters, and filtrate adds taurine 0.5g, dense orange juice, each 100ml of Fructus Citri Limoniae juice, Mel 200ml.Stir evenly, fine straining, packing sterilization.
Preliminary two routine situations on probation.
1, * * hotel manager, the man, 46 years old, all will by the emperor himself with 50 ° or more Chinese liquor about 1 jin often have after drinking dizziness, headache, gastrointestinal upset because of work relationship every day, can not control language etc. symptom.After taking this product 0.5-1 hour, above symptom obviously alleviates, and spiritedness is salubrious, and thinking is good feel efficiently.
2, staff's Huang *, the man 35 years old, does not like to drink at ordinary times, often once drink Chinese liquor 2-3 two and just be prone to nausea and tell, phenomenons such as dizziness, once obey this product 100ml after, begin again to drink, drink to 5 liang, ill symptoms in the past still do not occur, still keep waking state.
Claims (3)
1, a kind of help antialcoholic functional health beverage is characterized in that nine kinds of components and the formulated product of water, or with product that wherein set of dispense is made more than three kinds or three kinds.Its component and proportioning separately are:
0.5～15 part of Ampelopsis grossedentata (w/v)
0.5～15 part of Fructus Citri Sarcodactylis (w/v)
Orange 0.5～15 part (w/v)
0.5～15 part of Radix Puerariae (w/v)
0.5～15 part in Radix Glycyrrhizae (w/v)
0.1～5 part of taurine (w/v)
2～20 parts of concentrated orange juices (w/v)
2～20 parts of concentrated lemon juices (w/v)
5～60 parts of Mel (w/v)
0～60 part of drinking water (w/v)
2, the compound method of the described help antialcoholic of a kind of claim 1 functional health beverage.It is characterized in that above-mentioned set of dispense ratio carries out; Earlier but an Ampelopsis grossedentata of medicine-food two-purpose, orange, Radix Puerariae, Radix Glycyrrhizae mixed powder are broken into coarse powder; add an amount of extraction of water 2 times, merge extractive liquid, is concentrated into certain volume, adds taurine and stirs; add concentrated orange juice, Fructus Citri Limoniae juice and Mel mixing again and stir evenly, beverage is made in fine straining, fill, sterilization.
3, component according to claim 1 and proportioning is characterized by and be made into teabag, medicinal tea, fruit jelly, granule, tablet, capsule or oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03108564 CN1454526A (en) | 2003-03-26 | 2003-03-26 | Functional health-care beverage for helping to sobering one |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03108564 CN1454526A (en) | 2003-03-26 | 2003-03-26 | Functional health-care beverage for helping to sobering one |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100377659C (en) * | 2004-10-28 | 2008-04-02 | 刘国廉 | Alcohol neutralize drink |
| CN100435803C (en) * | 2006-06-07 | 2008-11-26 | 广州中医药大学 | Use of taurine in preparation of injection containing puerarin |
| CN100444885C (en) * | 2005-04-07 | 2008-12-24 | 韩勇 | Powder containing fingered citron and citron |
| CN102228280A (en) * | 2011-06-02 | 2011-11-02 | 汕头市生奥保健食品有限公司 | Greengage beverage and preparation method thereof |
| CN102640952A (en) * | 2012-03-14 | 2012-08-22 | 四川阆中煜群农产品开发有限责任公司 | Ginger in vinegar oral liquid and production process |
| CN102987474A (en) * | 2012-10-18 | 2013-03-27 | 田欢 | Anti-inebriation beverage |
| CN103141729A (en) * | 2013-03-25 | 2013-06-12 | 胡敏 | Fruit jelly for giving up drinking |
| CN104522639A (en) * | 2014-12-10 | 2015-04-22 | 甘肃陇神戎发药业股份有限公司 | Anti-intoxication, alcohol-expelling and liver-protection preparation and preparation process thereof |
| CN107348059A (en) * | 2017-09-01 | 2017-11-17 | 黄山华绿园生物科技有限公司 | Antialcoholic tea and its manufacture craft |
-
2003
- 2003-03-26 CN CN 03108564 patent/CN1454526A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100377659C (en) * | 2004-10-28 | 2008-04-02 | 刘国廉 | Alcohol neutralize drink |
| CN100444885C (en) * | 2005-04-07 | 2008-12-24 | 韩勇 | Powder containing fingered citron and citron |
| CN100435803C (en) * | 2006-06-07 | 2008-11-26 | 广州中医药大学 | Use of taurine in preparation of injection containing puerarin |
| CN102228280A (en) * | 2011-06-02 | 2011-11-02 | 汕头市生奥保健食品有限公司 | Greengage beverage and preparation method thereof |
| CN102228280B (en) * | 2011-06-02 | 2013-09-11 | 汕头市生奥保健食品有限公司 | Greengage beverage and preparation method thereof |
| CN102640952A (en) * | 2012-03-14 | 2012-08-22 | 四川阆中煜群农产品开发有限责任公司 | Ginger in vinegar oral liquid and production process |
| CN102987474A (en) * | 2012-10-18 | 2013-03-27 | 田欢 | Anti-inebriation beverage |
| CN103141729A (en) * | 2013-03-25 | 2013-06-12 | 胡敏 | Fruit jelly for giving up drinking |
| CN104522639A (en) * | 2014-12-10 | 2015-04-22 | 甘肃陇神戎发药业股份有限公司 | Anti-intoxication, alcohol-expelling and liver-protection preparation and preparation process thereof |
| CN107348059A (en) * | 2017-09-01 | 2017-11-17 | 黄山华绿园生物科技有限公司 | Antialcoholic tea and its manufacture craft |
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