CN1435203A - Hypoglycemic lozemge and producing method thereof - Google Patents
Hypoglycemic lozemge and producing method thereof Download PDFInfo
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- CN1435203A CN1435203A CN 02110050 CN02110050A CN1435203A CN 1435203 A CN1435203 A CN 1435203A CN 02110050 CN02110050 CN 02110050 CN 02110050 A CN02110050 A CN 02110050A CN 1435203 A CN1435203 A CN 1435203A
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- hypoglycemic
- lozemge
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- fructus momordicae
- momordicae charantiae
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Abstract
A hypoglycemic buccal lozenge for treating diabetes contains balsam pear powder, xylitol, mannitol, rebaudioside, menthol, citric acid, insulin activator, etc. Its advantages are high curative effect, low cost and no toxic by-effect.
Description
Technical field: the invention belongs to Chinese medicine preparation, particularly be the Chinese medicine preparation hypoglycemic lozemge and the production method thereof of obvious curative effects to be arranged for the treatment diabetes.
Background technology: diabetes are common endocrinopathyes, can cause severe complications, can cause blind or the like as common peripheral neuritis, multiple furuncle and phyma, retinopathy, therefore controlling blood poor is the major measure of treatment diabetes, and oral antidiabetic drug can only be treated type ii diabetes, and insulin dependent diabetes mellitus (IDDM) people essential every day of insulin injection, oral drug effect is low, it is poor to act on, and the preceding insulin injection of being greedy for money or food every day three brings misery and inconvenience to the patient; Fructus Momordicae charantiae is on the books as the Chinese medicine of China's treatment diabetes, but directly edible Fructus Momordicae charantiae requirement is bigger, do not reach the effect of effective treatment diabetes, Largeleaf Gymnema is the own in recent years blood sugar lowering Chinese medicine that confirms, decocting method requirement commonly used is bigger, do not reach the effect of effective treatment diabetes, demand preparing the Chinese medicine preparation of blood sugar lowering better efficacy urgently.
Summary of the invention: it is a kind of orally-taken blood sugar reducing medicine that primary raw material is formed in conjunction with adjuvant with Fructus Momordicae charantiae extract and Gymnema sylvestre extract that the object of the invention provides a kind of, and treatment diabetes effective percentage reaches hypoglycemic lozemge and the production method thereof more than 90%.
The object of the present invention is achieved like this, specifies as follows:
A kind of hypoglycemic lozemge, it contains following raw material: Fructus Momordicae charantiae powder, Largeleaf Gymnema powder, xylitol, mannitol, steviol glycosides, Mentholum, citric acid and insulin activator.
A kind of hypoglycemic lozemge, it is to form Chinese medicine preparation by following preparation of raw material by weight:
The better scope optimum range of material name effective range
Fructus Momordicae charantiae powder 10-35 20-30 23-28
Largeleaf Gymnema powder 10-30 15-25 15-22
Xylitol 5-25 8-20 10-17
Mannitol 25-55 30-50 35-45
Steviol glycosides 0.1-1 0.1-0.8 0.2-0.6
Mentholum 0.1-1 0.2-1 0.2-0.6
Twist lemon acid 0.1-1 0.1-0.6 0.1-0.5
Insulin activator 0.001-0.009 0.001-0.007 0.001-0.005
A kind of production method of above-mentioned hypoglycemic lozemge is;
1. at first get needed raw material ready according to above-mentioned requirements, and to Fructus Momordicae charantiae, Largeleaf Gymnema roguing, clean; With bright Fructus Momordicae charantiae squeeze the juice, filter clear juice, get ultrafiltrate through ultrafilter membrane again; Add the insulin activator in ultrafiltrate, carry out lyophilization again, the lyophilization thing is pulverized again, powdered is standby;
2. the adding of Largeleaf Gymnema raw material is had in the extraction pot of reflux, soak, reflux more after filtration, gets the water extract, waste then; Reconcentration becomes extractum; Dry again, with dry medicated powder crushing screening, powdered is standby;
3. with above-mentionedly processed standby Fructus Momordicae charantiae powder, the Largeleaf Gymnema powder weighs up mixing by proportioning raw materials, weigh up mannitol, steviol glycosides, Mentholum, citric acid more respectively, add in the mixed powder, fully mixing, through pelletize, tabletting, bottling, sterilization, get hypoglycemic lozemge finished product of the present invention again.
It is very satisfied that the effect of hypoglycemic lozemge of the present invention is made us, the para-insulin activity is greater than 400 ius/g after measured, momordica saponins is greater than 100mg/100g, gymnemic acid is greater than 5g/100g, pharmacology and human clinical's experiment through animal, without any side effects, the effective percentage of treatment diabetes reaches more than 90%, solved the problem that insulin can not be oral, having removed the diabetes patient must be by the misery of the supplementation with insulin of having an injection, and easy to use, cheap, a kind of really more satisfactory Remedies for diabetes.
Accompanying drawing 1 is hypoglycemic lozemge processing process figure
Description of drawings:
By can finding out in the accompanying drawing 1, hypoglycemic lozemge be by balsam pear powder and gymnema sylvestre powder be primary raw material again Add cells activated by insulin agent and xylitol, sweet mellow wine, stevioside, Natural menthol, citric acid etc. Auxiliary material processes;
Bright balsam pear is squeezed the juice with squeezer, gets bright Bitter Melon Juice, filters by plate and frame filter press again, gets clearly juice; Carrying out ultrafiltration, is 0.10u-0.80u through the filter membrane hole again, gets ultrafiltrate; Adding insulin in ultrafiltrate swashs Freeze drying is carried out in the agent of living, cryogenic temperature-40 ℃, and the highest intensification temperature is no more than 40 ℃, when freezing Between 36-72 hour, be dried to water content and be lower than 5% and finish; Again the freeze drying thing is pulverized by pulverizer, Cross sieve No. four, powdered, for subsequent use;
Again the gymnema sylvestre raw material is added in the multipotency Chinese medicine extracting tank with reflux, add 6-10 water doubly Soaked 20-60 minute, added then hot reflux 1 hour, filter through plate and frame filter press again, get water extraction liquid A For subsequent use; The right mistake adds 5-8 water doubly with its dregs of a decoction, and heating and refluxing extraction 1 hour refluxes and finishes by plate The frame filter press refilters, and gets water extraction liquid B, waste; With aforementioned gymnema sylvestre twice makes water for subsequent use again Extract A, B merge, and concentrate in vacuum concentration pot, and vacuum is 86kPa, and temperature 60-80 ℃, will Extract is concentrated to the medicinal extract of proportion 1.2; Again medicinal extract is packed into and carries out vacuum drying in the vacuum desiccator, Vacuum is 86kPa, temperature 60-80 ℃, is dried to the medicinal powder water content and is lower than 10% end; Again with drying Medicinal powder is pulverized, and crosses sieve No. four, and powdered is for subsequent use;
With above-mentionedly made balsam pear powder for subsequent use, the gymnema sylvestre powder weighs up mixing by the raw material proportioning; Divide again another name Go out sweet mellow wine, stevioside, Natural menthol, citric acid, add in the mixed powder, abundant mixing, again Carry out granulation, compressing tablet, every heavy 0.8g, bottling, sterilization namely obtain hypoglycemic lozemge of the present invention.
Above-mentioned sterilization refers to bottled medicine again through radiosterilization, the Co radiation sterilization, and the average overall absorbed dose of radiation is 5KGY, irradiation evenly can be finished the sterilization task.
The specific embodiment:
The raw material that hypoglycemic lozemge is made is embodiment by weight ratio:
Example 1, Fructus Momordicae charantiae 25, Largeleaf Gymnema 20, xylitol 14.2, mannitol 40, steviol glycosides 0.25, Natural menthol 0.5, citric acid 0.25, insulin activator 0.001.
Example 2 Fructus Momordicae charantiaes 40, Largeleaf Gymnema 50, xylitol 27, mannitol 75, steviol glycosides 0.5 Natural menthol 0.5, citric acid 0.4, insulin activator 0.002.
Example 3 Fructus Momordicae charantiaes 28, Largeleaf Gymnema 22, xylitol 18, mannitol 45, steviol glycosides 0.8 Natural menthol 0.6, citric acid 0.6, insulin activator 0.005.
Hypoglycemic lozemge production method embodiment:
At first get the bright Fructus Momordicae charantiae of 1000g, clean the back and squeeze the juice with squeezer, the reuse filter press filters, get clear juice, carry out ultrafiltration again, the filter membrane aperture is 0.50u, gets ultrafiltrate, in ultrafiltrate, add insulin activator 0.002, carry out lyophilization, cryogenic temperature-40 ℃, the highest intensification temperature is no more than 40 ℃, cooling time 48 hours is dried to water content and is lower than 5% end; The lyophilization thing is pulverized by pulverizer, crossed sieve No. four, obtain 40g Fructus Momordicae charantiae powder;
Largeleaf Gymnema raw material 1000g is joined in the multipotency Chinese medicine extraction jar that has reflux, and the water logging that adds 8000ml was steeped 30 minutes, and reflux is 1 hour then; After backflow finishes, filter by filter press, obtain water extract A, medicinal residues add 5 times water more then, heating and refluxing extraction 1 hour refluxes and finishes the back by the filter press filtration, gets water extract B, medicinal residues discard, water extract A, B are merged, carry out vacuum concentration in vacuum concentration pot, vacuum is 86kPa, 70 ℃ of temperature, extracting solution is concentrated to the extractum of proportion 1.2, carries out vacuum drying in the vacuum desiccator of again extractum being packed into, vacuum is 86kPa, 75 ℃ of temperature are dried to the medicated powder water content and are lower than 10% end; Pulverize through pulverizer again, cross sieve No. four, make Largeleaf Gymnema powder 50g;
At last by proportioning raw materials embodiment 2, weigh up Fructus Momordicae charantiae powder 40g, Largeleaf Gymnema powder 50g, xylitol 27g, mannitol 75g, steviol glycosides 0.5g, Natural menthol 0.5g, citric acid 0.4g mixing, mix thoroughly, tabletting, bottling, radiosterilization promptly get hypoglycemic lozemge.
Above-mentioned hypoglycemic lozemge is the powder of making by after the extracting solution drying, is processed into buccal tablet again, if it is just simpler to make liquor, medicated wine; If after making unguentum and concentrating promptly; If make pill, powder, also be easy to.
Claims (8)
1, a kind of hypoglycemic lozemge is characterized in that the Chinese medicine preparation of being made by the raw material of following weight ratio: Fructus Momordicae charantiae powder 10-35 Largeleaf Gymnema powder 10-30 xylitol 5-25 mannitol 25-55 steviol glycosides 0.1-1 Mentholum 0.1-1 citric acid 0.1-1 insulin activator 0.001-0.09.
2, hypoglycemic lozemge according to claim 1 is characterized in that the Chinese medicine preparation of being made by the raw material of following weight ratio: Fructus Momordicae charantiae powder 20-30 Largeleaf Gymnema powder 15-25 xylitol 8-20 mannitol 30-50 stevioside 0.1-0.8 Mentholum 0.2-1 citric acid 0.1-0.6 insulin activator 0.001-0.007.
3, hypoglycemic lozemge according to claim 1 is characterized in that the Chinese medicine preparation of being made by the raw material of following weight ratio: Fructus Momordicae charantiae powder 23-28 Largeleaf Gymnema powder 15-22 xylitol 10-17 mannitol 35-45 stevioside 0.2-0.6 Mentholum 0.2-0.6 citric acid 0.1-0.5 insulin activator 0.001-0.005.
4, a kind of production method of above-mentioned hypoglycemic lozemge is:
1. at first get needed raw material ready according to above-mentioned requirements, and to Fructus Momordicae charantiae, Largeleaf Gymnema roguing, clean: with bright Fructus Momordicae charantiae squeeze the juice, filter clear juice, get ultrafiltrate through ultrafilter membrane again; Add the insulin activator in ultrafiltrate, carry out lyophilization again, the lyophilization thing is pulverized again, powdered is standby;
2. the adding of Largeleaf Gymnema raw material is had in the extraction pot of reflux, soak, reflux more after filtration, gets the water extract, waste then; Reconcentration becomes extractum; Dry again, with dry medicated powder crushing screening, powdered is standby;
3. with above-mentionedly processed standby Fructus Momordicae charantiae powder, the Largeleaf Gymnema powder weighs up mixing by proportioning raw materials, weigh up mannitol, steviol glycosides, Mentholum, citric acid more respectively, add in the mixed powder, fully mixing, through pelletize, tabletting, bottling, sterilization, get hypoglycemic lozemge finished product of the present invention again.
5, the production method of hypoglycemic lozemge according to claim 4 is characterized in that to such an extent that carry out ultrafiltration again behind the Fructus Momordicae charantiae clear juice, and the ultrafiltration fenestra is 0.10u-0.80u.
6, the production method of hypoglycemic lozemge according to claim 4, it is characterized in that the Fructus Momordicae charantiae ultrafiltrate adds the insulin activator and carries out lyophilization and be meant cryogenic temperature-40 ℃, the highest intensification temperature is no more than 40 ℃, cooling time 36-72 hour, is dried to water content and is lower than 5% end.
7, the production method of hypoglycemic lozemge according to claim 4 is characterized in that Largeleaf Gymnema water extract concentrates in vacuum concentration pot, vacuum is 86kPa, temperature 60-80 ℃, extracting solution is concentrated to the extractum of proportion 1.2.
8, the production method of hypoglycemic lozemge according to claim 4, it is characterized in that Largeleaf Gymnema extractum is packed into carries out vacuum drying in the vacuum desiccator, and vacuum is 86kPa, temperature 60-80 ℃, is dried to the medicated powder water content and is lower than 10% and finishes.
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|---|---|---|---|
| CN 02110050 CN1435203A (en) | 2002-01-30 | 2002-01-30 | Hypoglycemic lozemge and producing method thereof |
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| CN 02110050 CN1435203A (en) | 2002-01-30 | 2002-01-30 | Hypoglycemic lozemge and producing method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008057968A3 (en) * | 2006-11-02 | 2008-09-12 | Coca Cola Co | Anti-diabetic composition with high-potency sweetener |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| CN103584017A (en) * | 2013-11-29 | 2014-02-19 | 周县萍 | Balsam pear buccal tablet and preparation method thereof |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
-
2002
- 2002-01-30 CN CN 02110050 patent/CN1435203A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| WO2008057968A3 (en) * | 2006-11-02 | 2008-09-12 | Coca Cola Co | Anti-diabetic composition with high-potency sweetener |
| JP2010509232A (en) * | 2006-11-02 | 2010-03-25 | ザ・コカ−コーラ・カンパニー | Anti-diabetic composition comprising high intensity sweetener |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| JP2014139224A (en) * | 2006-11-02 | 2014-07-31 | The Coca-Cola Company | Antidiabetic composition containing high-potency sweetener |
| CN103584017A (en) * | 2013-11-29 | 2014-02-19 | 周县萍 | Balsam pear buccal tablet and preparation method thereof |
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