CN1419904A - Beauty skin-protection nano-liquid and preparing process thereof - Google Patents
Beauty skin-protection nano-liquid and preparing process thereof Download PDFInfo
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- CN1419904A CN1419904A CN 01129074 CN01129074A CN1419904A CN 1419904 A CN1419904 A CN 1419904A CN 01129074 CN01129074 CN 01129074 CN 01129074 A CN01129074 A CN 01129074A CN 1419904 A CN1419904 A CN 1419904A
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Abstract
A face-beautifying skin-protecting nano-liquid is prepared from choosing raw materials and Chinese medicine through dissolving the raw materials and medicines, which are difficult to dissolve in water, in solvent, dissolving others in water, adding surfactant and assistant to non-aqueous solution, adding drop wise the non-aqueous solution to aqueous solution while stirring and ultrasonic vibration, separating out said solvent, and standing for a certain time.
Description
The invention belongs to the preparation field of cosmetics and skincare product, specifically relate to the Chinese medicine of the multiple function relevant with beauty and skin care and the active princlple in the Western medicine are prepared into nanoparticle, and become beauty skin-protection nano-liquid with the component reasonable combination commonly used of beauty and skin care.
Skin is the maximum and the easiest organ of seeing as health, and its state has reflected many and the relevant situation of your health.Other position of face skin and health is compared, and has its own uniqueness.The first, " first and figure also belong to bone and connect muscle, close in the gas ear with blood " (" Ling Shu Miraculous Pivot or Divine Axis.The sick new shape in pathogen root of Dahurian angelica mansion "), so facial fitness whether, be subjected to the influence of the promptly interior environment of holistic health.The second, " its face is clothing not " (the same) do not have to hide and do not have retaining outside it is exposed to throughout the year, is subject to the exopathogen invasion and attack, and be so its fitness whether, closely related with the variation of external environment again." confluence of all yang-channels, all with face ", lid speech face be that sun gathers part, " its vim and vigour all go up in face for the twelve regular channels, 365 networks " (the same) arranged because meridians have the operation QI and blood in the fourteen channels arteries and veins, moisten and support the whole body, resist exopathogen, the effect of defendance body, mostly up again in women's head-ornaments, so when meridian function is unusual, the QI and blood supply of women's head-ornaments portion is obstructed, and U.S.'s property defective then easily takes place to decrease malnutrition.Internal organs closely link to each other with face by meridians.Each is main to some extent for internal organs, and each is department to some extent, so arbitrary internal organs generation pathological changes all can be reflected to women's head-ornaments portion by the different forms of expression.Equally, external environment condition all can exert an influence to the impression and the function of face skin.As antibacterial in temperature, humidity, ultraviolet irradiation, the atmosphere etc.As mentioned above, the general principle of face skin maintenance is a balance of safeguarding internal and external environment.The balance of environment in safeguarding is promptly coordinated negative and positive in the body, makes the five internal organs stable, and six internal organs are gentle, and meridians are unobstructed, and QI and blood is in harmonious proportion, and with the integral body of a health, guarantees the partial U.S. of appearance.Safeguard the balance of external environment, promptly resort to all kinds of methods, create a good local environment to face skin, in order to the existence and the growth of skin., it is considered herein that: should keep the good mental status, be careful in one's diet and rational nutrition supply, the motion (comprising massage) and the Drug therapy in case of necessity of rule arranged,, create the good internal medium of healthy skin to keep the health status of health for this reason; Rationally use cosmetics and skincare product also to can be skin and create a good local environment, also be very important with multiple function.
The present invention proposes multiple the attacking that cosmetics and skincare product should have and can and provide its preparation method, its objective is the effect that improves cosmetics and skincare product.Beauty skin-protection nano-liquid should have following some characteristics and function.
1, active princlple should be able to see through skin (epidermis and corium) fast, enters skin inside.
For this reason, require in the skincare liquid active princlple at first must with skin can be compatible and affine (can not be compatible and affine as if active princlple and skin, then must carry out can using after the modification) to its surface; Secondly, the granule of active princlple should have enough little size, generally should be less than 1000nm, and preferably can be less than 100nm.
2, active princlple should have the function of blood circulation promoting and blood stasis dispelling
Blood circulation promoting and blood stasis dispelling, microcirculation improvement.Help providing the Skin Cell growth required nutrition, impel constantly coming off of epidermis dead cell; Help the absorption after active princlple sees through skin; Help the unimpeded of channels and collaterals running.
3, active princlple should have the antioxidative function
Have sufficient scientific evidence to show that the antioxidative nutrient has decisive role to skin health, can delaying senility course, be to naturally-aged or presenility effect is all arranged.It can protect skin to avoid the harmful effect of free radical, and this material appears in air, flue dust and the ultraviolet irradiation of pollution, and results from the eubolism process of body.This class nutrient has vitamin A, C and E; Trace element such as selenium etc.; Biological flavone; Nucleic acid, terpenes, enzyme, hydroxy acid (AHAs, BHAs) etc.
4, should to have that moisture preserving function preserves moisture be to make skin keep young important step to active princlple, and skin is greatly taken on a new look.The primary effect of preserving moisture is to become barrier in that skin surface is capable, prevents the forfeiture of moisture, makes skin bright and clean, delicate, and the dead cell of skin table ginseng layer is come off.
5, active princlple should have germ-resistant function noxious bacteria soak attack be the trouble of causing the various skin disease because of, the active princlple with sterilizing function can become protective layer at the skin surface row, also can see through skin, kills the antibacterial of skin inside (as hair follicle etc.).
6, active princlple should have other function such as cleaning skin, removes dead bark, treat some dermatosis (as acne, eczema, mottle etc.) in case of necessity.The objective of the invention is to realize by following technical proposals:
1. according to the functional requirement of beauty skin-protection nano-liquid, select required active princlple and content; According to required active princlple and selected raw material and the medicine (Chinese herbal medicine, synthetic drug etc.) that this active princlple is provided of content.
2. select then one or more solvents, the raw material and the medicine (Chinese medicine and synthetic drug) that are insoluble in water are made solution or saturated solution, raw material soluble in water and medicine are made aqueous solution.
Chinese medicine is different from Western medicine, almost in the former medicine of each Chinese medicine, all contain multiple active drug component, therefore, can the selection of solvent and dissolution conditions be directly connected to each active princlple in the former medicine of Chinese medicine and be extracted to greatest extent and can not destroy its component and structure.As the Radix Ginseng that extracts tonic can not select the ethanol (95%) of high concentration for use, if with 95% ethanol lixiviate, ginseng polysaccharide's loss is very big, and the immunization of Radix Ginseng just shows not obviously, must select low-concentration ethanol (containing the alcohol amount less than 60%) for use; And for example, must select stripping and extraction under the lower temperature conditions for use to containing polypeptide protein and the Chinese medicine that contains volatile oil; To the heterogeneity active component in the former medicine of Chinese medicine; The solvent and the corresponding leaching condition that often will design more than one extract.Selected solvent must can dissolve each other with water, or volatile solution.
According to active components different in the medicine, available solvent has:
(1) alcohols: monohydric alcohol or polyhydric alcohol
The monohydric alcohol of often selecting for use has difference to contain the ethanol that alcohol is measured, propanol, butanols etc.
The polyhydric alcohol of often selecting for use has ethylene glycol, propylene glycol, glycerol etc.
(2) esters:
That often selects for use has newborn ester ethyl ester, butyl lactate, ethyl acetate, butyl acetate, a γ-Ding Suan lactone etc.
(3) ketone:
Mainly contain acetone, butanone, methyl iso-butyl ketone (MIBK), Ketohexamethylene, methyl amylketone etc.;
(4) acid, bases;
Commonly used have acetic acid, hydrochloric acid and a sodium hydroxide etc.;
(5) other solvent based;
Mainly contain pyridine, oxolane etc.
Owing to reason such as poisonous is not often used, as dimethylbenzene, pure ethers, chlorinated hydrocarbon solvent class and terpenes solvent.
2, contain the preparation of surfactant solution
At first be to select one or more surfactants and cosurfactant for use.Active component and structure according to medicine are selected suitable surfactant and cosurfactant for use; because the surfactant of selecting for use will form protective layer on the medicine nano micro particle surface of making; therefore, selected surfactant must be nontoxic and edible.Surfactant and the cosurfactant that can Gong select for use have:
(1) anionic surfactant:
That often selects for use has sodium lauryl sulphate, a dodecylbenzene sodium sulfonate etc.
(2) nonionic surfactant
That often selects for use has octadecyl polyoxyethylene, fatty acid anhydrous sorbitol polyoxyethylene and a polysorbate etc.
(3) amphoteric surfactant
Can select amine carboxylate and quaternary ammonium salt carboxylate etc. for use
(4) cationic surface active agent
Can select cetyl trimethyl ammonium bromide etc. for use
(5) cosurfactant;
Behind the selected surfactant, can select corresponding cosurfactant, commonly used is the alcohols of medium carbon chain lengths, as lauryl alcohol, and hexadecanol etc.The overwhelming majority who relates in the practicality is a mixed surfactants solutions, mixed solution often demonstrates the unexistent surface characteristic of single surfactant solution, for example the γ of mixed solution can significantly be lower than the surfactant solution of one pack system sometimes, and for example has only mixed surfactants solutions can reach ultralow interfacial tension in profit circle the inside.(＜10mN/m)。
Surfactant and auxiliary agent can be added in the water or be added in the nonaqueous solvent.
3. replacing solvent
Stir with the coefficient condition of supersonic vibration under, the non-aqueous solution that will contain medicine slowly is added dropwise to (or spraying adds) and contains in the aqueous solution of surfactant, dropwises and after the depositing of certain hour, promptly forms the water slurry of medicine nano micro particle.In particular cases, still need, can form the water slurry of medicine nano micro particle through removing nonaqueous solvent (can select fractional distillation for use, distilling under reduced pressure and freezing method such as separate).
4. the separation of nonaqueous solvent and recovery
Differences of physical properties according to used nonaqueous solvent and water, select the separation and the recovery method of suitable nonaqueous solvent for use, for example, if the boiling point of used nonaqueous solvent is lower than water, then can selects distillation respectively for use, divide methods such as gold-plating or reduced pressure distillation according to the difference size of boiling point; If the freezing point of used nonaqueous solvent is more much lower than water, then can select for use freezing method to separate.
The present invention can be implemented under the prerequisite of the active component that do not destroy in the medicine and structure, the preparation beauty skin-protection nano-liquid.Method is reliable, and is easy to operate, and required energy consumption is very low, also need not complex device, do not produce environmental pollution, and its prepared beauty skin-protection nano-liquid is compared with traditional skincare liquid, and cosmetic result is more remarkable or can significantly reduce dosage.
Embodiment one
1. raw material and medicine.
(1) water-soluble material and medicine:
Propylene glycol 50ml
Pure water 600ml
Vitamin C 0.5g
(2) pure dissolubility raw material and medicine
Sanguis Draxonis 1.5g
Myrrha 1.5g
Olibanum 1.5g
Vitamin A 0.5g
Vitamin e1 .0g
(3) part Chinese medicine
Radix Notoginseng 2.0g
Radix Panacis Quinquefolii 2.0g
Lignum Sappan 2.0g
This three flavors Chinese medicine added the 30ml soaked in absolute ethyl alcohol 3～5 days earlier through pulverizing, levigate, for quickening stripping, can add supersonic vibration.Cross leaching filtrate; Filtering residue adds water 600ml.Get filtrate after decocting, filtrate is diluted to 600ml, adds propylene glycol 50ml again, and vitaminize 0.5g makes aqueous solution.
2. contain the alcoholic solution preparation of surfactant
Surfactant sodium lauryl sulphate 0.3g
Cosurfactant lauryl alcohol 0.3g
With pure dissolubility raw material and medicine Sanguis Draxonis 1.5g, Myrrha 1.5g, Olibanum 1.5g, vitamin A 0.5g, vitamin e1 .0g join in the alcohol extract of 30ml Radix Notoginseng, Radix Panacis Quinquefolii, Lignum Sappan, stirring and dissolving, can add supersonic vibration for accelerating dissolving, after treating to dissolve fully, add surfactant and cosurfactant again, make mixed alcohol solution.
3. replacing solvent:
Stir with the supersonic vibration combined effect under, mixed alcohol solution slowly is added drop-wise in the aqueous solution, rate of addition is 1～2 of a per second, dropwises and after certain hour is deposited, promptly forms beauty skin-protection nano-liquid.Measure with laser particle analyzer through " the compound National Key Laboratory of material ", its average grain directly is 69.2nm, and through Wuhan University's transmissioning electric mirror determining, granule is spherical.
Embodiment two
1. raw material and medicine
(1) water-soluble material and medicine
Propylene glycol 60ml
Vitamin C 0.5g
Pure water 600ml
(2) pure dissolubility raw material and medicine
Myrrha 3g dehydrated alcohol 40ml
Olibanum 3g vitamin A 0.5g
Propolis 3g vitamin e1 .0g (3) part Chinese medicine
Radix Salviae Miltiorrhizae 3g Radix Notoginseng 3g Radix Astragali 3g
Ramulus Mori 3g Herba Eupatorii 3g Lignum Sappan 2g
Rhizoma Chuanxiong 1.5g Cortex Albiziae 1.5g Herba Menthae 1.5g
Radix agastaches 0.5g Flos Caryophylli 0.5g this ten simply Chinese medicine earlier through pulverize, levigate, added the 30ml soaked in absolute ethyl alcohol 3～5 days, for quickening stripping, can add supersonic vibration.Cross leaching filtrate; Filtering residue adds water 600ml.Get filtrate after decocting, filtrate is diluted to 600ml, adds propylene glycol 50ml again, and vitaminize 0.5g makes aqueous solution.Add the 60ml propylene glycol again, vitaminize C0.5g makes aqueous solution
2. contain the alcoholic solution preparation of surfactant
Surfactant sodium lauryl sulphate 0.45g
Cosurfactant lauryl alcohol 0.45g
Pure dissolubility raw material and medicine are joined stirring and dissolving in the 40ml Chinese medicine alcohol extract, can add supersonic vibration, after treating to dissolve fully, add surfactant and cosurfactant again, make mixed alcohol solution for accelerating dissolving
3. replacing solvent
Stir with the supersonic vibration combined effect under, mixed alcohol solution slowly is added drop-wise in the aqueous solution, rate of addition is 1～2 of a per second, dropwises and after certain hour is deposited, promptly forms beauty skin-protection nano-liquid.Measure with laser particle analyzer through " the compound National Key Laboratory of material ", its average grain directly is 69.2nm, and through Wuhan University's transmissioning electric mirror determining, granule is spherical, and its average grain particle diameter is less than 100nm.
Claims (5)
1. beauty skin-protection nano-liquid and preparation method thereof is characterized in that selecting proper raw material and medicine (Chinese medicine and synthetic drug) according to set-up function, selects suitable solvent that it is made non-aqueous solution and aqueous solution respectively; Select suitable surfactant and cosurfactant, dissolve in above-mentioned non-aqueous solution or the aqueous solution; At last with non-aqueous solution stir with the coefficient condition of supersonic vibration under slowly drip or spraying adds in the aqueous solution, adopts suitable method with unnecessary nonaqueous solvent removal, can obtain beauty skin-protection nano-liquid.
2. beauty skin-protection nano-liquid according to claim 1 and preparation method thereof is characterized in that selecting proper raw material and medicine (Chinese medicine and synthetic drug) according to the function of setting.
3. beauty skin-protection nano-liquid according to claim 1 and preparation method thereof, it is characterized in that selecting suitable solvent (water and nonaqueous solvent), raw material and medicine are made aqueous solution and non-aqueous solution two parts respectively, and solution concentration can be from low concentration until saturated concentration.
4, beauty skin-protection nano-liquid according to claim 1 and preparation method thereof, the preparation method that it is characterized in that the nanoparticle of insoluble drug according to claim 1, it is characterized in that described surfactant and cosurfactant must be safe and edible, surfactant can be selected anionic, nonionic, amphoteric and cationic surface active agent for use, and cosurfactant can be selected the alcohols of medium carbon chain lengths etc. for use.Aqueous surfactant solution concentration is 0.01-1.0%.
5. beauty skin-protection nano-liquid according to claim 1 and preparation method thereof is characterized in that changing solvent.The preparation method of the nanoparticle of insoluble drug according to claim 1, be to adopt under stirring or stirring and ultrasonic combined effect condition when it is characterized in that changing solvent, slowly dropping or spraying add (or containing in the aqueous solution of surfactant) in the entry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01129074 CN1419904A (en) | 2001-11-16 | 2001-11-16 | Beauty skin-protection nano-liquid and preparing process thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01129074 CN1419904A (en) | 2001-11-16 | 2001-11-16 | Beauty skin-protection nano-liquid and preparing process thereof |
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| CN1419904A true CN1419904A (en) | 2003-05-28 |
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| CN 01129074 Pending CN1419904A (en) | 2001-11-16 | 2001-11-16 | Beauty skin-protection nano-liquid and preparing process thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623183A (en) * | 2013-09-18 | 2014-03-12 | 昆明仟草生物科技有限公司 | Preparation method and application of dragon's blood extract and astringent made from dragon's blood extract |
| CN105997802A (en) * | 2016-06-21 | 2016-10-12 | 登封市科技企业孵化服务中心 | Beautifying and skin-protecting nano-emulsion |
-
2001
- 2001-11-16 CN CN 01129074 patent/CN1419904A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623183A (en) * | 2013-09-18 | 2014-03-12 | 昆明仟草生物科技有限公司 | Preparation method and application of dragon's blood extract and astringent made from dragon's blood extract |
| CN103623183B (en) * | 2013-09-18 | 2016-07-06 | 昆明仟草生物科技有限公司 | The preparation method of Sanguis Draxonis extract and purposes and astringent thereof |
| CN105997802A (en) * | 2016-06-21 | 2016-10-12 | 登封市科技企业孵化服务中心 | Beautifying and skin-protecting nano-emulsion |
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