CN1419889A - Method for non-invasive clinical monitoring intracranial edema - Google Patents
Method for non-invasive clinical monitoring intracranial edema Download PDFInfo
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- CN1419889A CN1419889A CN 02133518 CN02133518A CN1419889A CN 1419889 A CN1419889 A CN 1419889A CN 02133518 CN02133518 CN 02133518 CN 02133518 A CN02133518 A CN 02133518A CN 1419889 A CN1419889 A CN 1419889A
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Abstract
A method for clinically monitoring the intracranial edema without wound is disclosed. A low-frequency electric current flows through the craniocerebral surface to generate a current field. When the tissue structure in the current field changes, the electric current field is redistributed to reflect the change of intracranial edema, which is detected by phase change and displayed by computer and display device.
Description
One, technical field
The present invention relates to digital medical monitoring new technique, be specifically related to the method for non-invasive clinical monitoring intracranial edema.
Two, background technology
It is the pathological reaction of cerebral tissue to the different causes of disease that edema appears in intracranial.Correct character and the evolution process of in time estimating intracranial edema is many critical patient's diagnosis of relation and treatment key of success.The edema of intracranial occurs in the special environment of complete closed, and present diagnosis to intracranial deep edematous condition is the experience according to the clinical accumulation of doctor, and the detection means commonly used of doctor institute reference is CT, conventional magnetic resonance and diffusion-weighted nuclear magnetic resonance, NMR.The CT radioactivity is strong, can not put patient for a long time under radiation, thereby can't become conventional monitoring means.Magnetic resonance imaging is clear, but equipment is huge, costs an arm and a leg, and the persistent period is short, also will add special contrast agent in case of necessity, can not carry out for a long time the critical patient, other, a real-time monitoring.
1980, U.S. Schuier carried out record according to impedance method to the impedance variation of cat cerebral ischemia water shoulder blade, found that cerebral edema made the impedance of brain cortex rise to 660 ohm/cm from 282 ohm/cm in two hours.Britain Suga also adopts impedance method to measure the cerebral infarction of cat, finds identical result.1994, doctor Itkis was reporting on the Acta Neurcchir. journal: the method for placing electrode after he adopts and opens cranium on cerebral dura mater is surveyed impedance variation, can detect the generation and the differentiation of cerebral edema.(operational approach is finished by clinician's experiment).They do not have deep research and understanding to the relation of current field and electrical impedance.
Order was 7 in 2002 6, southwest information centre of the Ministry of Science and Technology looks into new center and sees in the document that to detecting there is a patent in the U.S. abroad, it is the device of noinvasive electromagnetism real-time monitoring brain specific region physiological change, this device utilizes the local impedance of electromagnetic field monitoring brain material and liquid to change, particularly monitor the cerebral edema situation that brain injury causes in real time, this patent proposes the cerebral edema tissue first has different electrical impedance with other cerebral tissue, utilizes detection electrical impedance situations of change such as electromagnetic transducer.Show the non-foreign body method of perturbation of the present invention of this patent, electrical impedance image formation method through contrast.At present, international and domestic in the process of treatment cerebral edema hematoma disease, lack the data of real-time edema hematoma differentiation, can not in real time, dynamically observe the situation of change that patient breaks away from intracerebral hematoma, treatment has certain blindness.
Three, summary of the invention
At the deficiency of prior art and method, the present invention proposes to be applied to non-invasive clinical monitoring intracranial edema with current field impedance image formation method first.Its technology contents is as follows:
The method of non-invasive clinical monitoring intracranial edema, low-frequency current is injected on cranium brain surface to measurand, in the volumetrical conductor of cranium brain, form a current field, when the organizational structure of electric current field domain changes, current field will redistribute, and carry out the non-invasive clinical monitoring by phase-detection by computer and display screen;
Its concrete grammar is: add electric current from front and back, head surface point of symmetry with the even-even electrode, write down the numerical value of current potential or impedance, inferred the situation of intracranial hematoma and edema again by current potential numerical value or impedance value.Described even-even electrode is arbitrary even-even electrode of 2-16 centering.Described even-even electrode is 2 or 16 counter electrode.
The present invention passes through the change of Measured Boundary current potential, the trend of reflection of noinvasive ground and evaluation of tissue structural change.Based on above-mentioned technology, can be a constant current field with equivalence in people's the head, the edema of generation is considered as the disturbance to cranium brain constant current field, and the border current potential of the current field field domain of redistribution directly reflects the changes of brain state.Can provide a kind of inexpensive, non-invasive, bed other to use, can show the device of the evolving state of brain deep hematoma and edema continuously by the present invention, and can develop series of products.
Four, Figure of description
Fig. 1 is a principle of the invention block diagram.
Fig. 2 is an embodiment of the present invention measuring principle figure.
Fig. 3 is the impedance variation curve chart.
Fig. 4 is an embodiment circuit diagram.
Five, the specific embodiment
Referring to Fig. 1, technical scheme of the present invention is realized by constant-current source, current potential detection, three functional modules of phase-detection.The annexation of each module: by the electrical stimulation signal of a current constant of constant-current source output, electrical stimulation is carried out at brains position by the electrode pair patient, and by output electrode to the cranium brain because of after edema causes the signals collecting of change to amplify, dividing two-way to carry out current potential detects and phase-detection, compare detecting the potential value of output signal and potential value, the phase place of phase place and input signal, and carry out computing by computer and related software, with variation tendency, position and the size of figure, image, demonstration intracranial edema.
The present invention is an even-even current potential synchronized sampling, with the figure Holter Monitor of 5-8 days continuous dynamically recording cranium table current potentials.The demonstration of instrument and analytical system are used microcomputer and are finished, and not only can write down the differentiation curve of edema automatically, and the mode of application topography represents the particular location and the coverage of edema.
Example 1: adopt the present invention, use two counter electrode from front and back, head surface point of symmetry and add electric current, form current field, the numerical value of record current potential or impedance is inferred intracranial hematoma and edema by current potential numerical value or impedance value again.
Connecting mode: can adopt 16 counter electrode to carry out ordered arrangement by the head surface.
Measuring principle, as Fig. 2 institute not.
Measurement result, referring to Fig. 3, the left side is hemorrhage formation hematoma earlier, occurs edema then around the hematoma.The right side is normal.It among the figure left and right sides impedance variation correlation curve.
Conclusion 1: hematoma hemorrhage side impedance occurs showing as and descends.Ab section among the figure.
Conclusion 2: after the stopped bleeding, impedance is risen, and represents edema to occur.The bc section is that edema constantly increases the weight of.The c point is the most serious point for edema develops into.
Conclusion 3: edema begins to alleviate, until the edema complete obiteration.On behalf of edema, the cd section constantly alleviate in time, to the then edema complete obiteration of d point.
Fig. 4 is an embodiment of the invention circuit diagram, by constant-current source 1., 3. 2. the current potential detecting unit form with phase detection unit.
1, characteristics of the present invention
1) proposes first " foreign matter disturbance " method, be " impedance imaging " mode non-invasive monitoring brain water The swollen theoretical foundation of having established;
2) analyze the capacitive reactance characteristic of brain tissue, obtained the reliable parameter index that oedema changes, to oedema Change and Development, increased intracranial pressure valid data are provided, have important clinical value to saving life;
3) adopted two road current potential synchronized samplings to multichannel, Graphics Application, image mode show monitoring Information, and will make monitoring curve develop into three-dimensional from two dimension, not only can monitor the evolving trend of oedema, Can also effectively observe the spatial distribution state of oedema;
4) use extensive FPG chip able to programme, effectively reduced volume reduces power consumption, adopts simultaneously Modern DSP technology, make the data acquisition digitlization, realized that each channel characteristic height is consistent.
Claims (3)
1, the method for non-invasive clinical monitoring intracranial edema, it is characterized in that: low-frequency current is injected on the cranium brain surface to measurand, in the volumetrical conductor of cranium brain, form a current field, when the organizational structure of electric current field domain changes, current field will redistribute, and carry out the non-invasive clinical monitoring by phase-detection by computer and display screen;
Its concrete grammar is: point of symmetry add electric current with the even-even electrode before and after the head surface, and the numerical value of surveying record current potential or impedance is inferred the situation of intracranial hematoma and edema again by current potential numerical value or impedance value.
2, the method for non-invasive clinical monitoring intracranial edema according to claim 1, it is characterized in that: described even-even electrode is the arbitrary even-even electrode of 2-16 centering.
3, the method for non-invasive clinical monitoring intracranial edema according to claim 1 and 2, it is characterized in that: described even-even electrode is 2 or 16 counter electrode.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 02133518 CN1419889A (en) | 2002-07-24 | 2002-07-24 | Method for non-invasive clinical monitoring intracranial edema |
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| CN 02133518 CN1419889A (en) | 2002-07-24 | 2002-07-24 | Method for non-invasive clinical monitoring intracranial edema |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006135520A1 (en) * | 2005-06-09 | 2006-12-21 | The Regents Of The University Of California | Volumetric induction phase shift detection system for determining tissue water content properties |
| CN102525458A (en) * | 2012-02-27 | 2012-07-04 | 重庆博恩富克医疗设备有限公司 | Device for monitoring hydrocephalus and encephaledema |
| CN102579009A (en) * | 2012-02-27 | 2012-07-18 | 重庆博恩富克医疗设备有限公司 | Electric signal processing unit for monitoring hydrocephalus and encephaledema |
| CN102579008A (en) * | 2012-02-27 | 2012-07-18 | 重庆博恩富克医疗设备有限公司 | Device and method for monitoring hydrocephalus and encephaledema |
| CN102727199A (en) * | 2012-07-23 | 2012-10-17 | 重庆博恩富克医疗设备有限公司 | Brain edema change measuring method based on minimum impedance frequency |
-
2002
- 2002-07-24 CN CN 02133518 patent/CN1419889A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006135520A1 (en) * | 2005-06-09 | 2006-12-21 | The Regents Of The University Of California | Volumetric induction phase shift detection system for determining tissue water content properties |
| CN102525458A (en) * | 2012-02-27 | 2012-07-04 | 重庆博恩富克医疗设备有限公司 | Device for monitoring hydrocephalus and encephaledema |
| CN102579009A (en) * | 2012-02-27 | 2012-07-18 | 重庆博恩富克医疗设备有限公司 | Electric signal processing unit for monitoring hydrocephalus and encephaledema |
| CN102579008A (en) * | 2012-02-27 | 2012-07-18 | 重庆博恩富克医疗设备有限公司 | Device and method for monitoring hydrocephalus and encephaledema |
| CN102579009B (en) * | 2012-02-27 | 2013-10-23 | 重庆博恩富克医疗设备有限公司 | Electric signal processing unit for monitoring hydrocephalus and encephaledema |
| CN102525458B (en) * | 2012-02-27 | 2013-11-06 | 重庆博恩富克医疗设备有限公司 | Device for monitoring hydrocephalus and encephaledema |
| CN102727199A (en) * | 2012-07-23 | 2012-10-17 | 重庆博恩富克医疗设备有限公司 | Brain edema change measuring method based on minimum impedance frequency |
| CN102727199B (en) * | 2012-07-23 | 2014-04-23 | 重庆博恩富克医疗设备有限公司 | Brain edema change measuring method based on minimum impedance frequency |
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