CN102579009A - Electric signal processing unit for monitoring hydrocephalus and encephaledema - Google Patents

Electric signal processing unit for monitoring hydrocephalus and encephaledema Download PDF

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CN102579009A
CN102579009A CN2012100457338A CN201210045733A CN102579009A CN 102579009 A CN102579009 A CN 102579009A CN 2012100457338 A CN2012100457338 A CN 2012100457338A CN 201210045733 A CN201210045733 A CN 201210045733A CN 102579009 A CN102579009 A CN 102579009A
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hydrocephalus
signal
module
cerebral edema
monitor
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CN102579009B (en
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郑翊
蒋辉
吴琪
胡少雄
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CHONGQING BOEN FUKE MEDICAL EQUIPMENT Co Ltd
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CHONGQING BOEN FUKE MEDICAL EQUIPMENT Co Ltd
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Abstract

An electric signal processing unit for monitoring hydrocephalus and encephaledema comprises a receiving electrode, a signal-processing digital converter, an orthogonal regulator, a detector, a parameter evaluator, an impedance analyzer and an assessment instrument. Electromagnetic waves change after passing through a human brain, so that specific circumstances of the hydrocephalus and encephaledema can be evaluated by comparing attenuation coefficient, relative phase shift, propagation time difference and complex wave value K of the electromagnetic waves before entering into the human brain and after passing through the human brain. According to the invention, electric signals are processed to calculate the parameter change value of the electromagnetic waves; and compared with the conventional invasive monitoring method, the electric signal processing unit is matched with a monitor and can realize 24-hour monitoring, so that medical security in treatment of the hydrocephalus and encephaledema is improved remarkably.

Description

Be used to monitor the electric signal process unit of hydrocephalus and cerebral edema
Technical field
The present invention relates to a kind of signal processing apparatus of medical apparatus and instruments, particularly a kind of electric signal process unit of monitoring hydrocephalic medical apparatus and instruments.
Background technology
The known condition of hydrocephalus is at the encephalocoele or the ventricles of the brain, the excessive buildup of cerebrospinal fluid (CSF).Under normal circumstances, cerebrospinal fluid is that the running of brain is most important.Carry nutrient and refuse from brain, and create the neonychium of a liquid.But the excessive accumulation of cerebrospinal fluid is to the disproportionate pressure of brain, and possibly cause brain cell and tissue injury.Therefore, medical condition, the proper flow that the absorption of directly interrupting cerebrospinal fluid gets into blood finally causes hydrocephalus with to create cerebrospinal fluid too much.
The human potential that hydrocephalus influences institute's has age can be divided into two big types with classification: obtain the congenital hydrocephalus and the day after tomorrow hydrops.Congenital hydrocephalus is when birth, can be in the gene unconventionality of the growth and development stage of fetus, premature labor, or the result of influence.By contrast, obtaining hydrops the day after tomorrow is that some body reason pathological changes of people causes, but is not limited only to angiopathy, injury of head or injury of head.Cause adult's apoplexy, hemorrhage, or the hydrops of these two categories of brain trauma, be called as ultravacuum hydrocephalus and normal pressure hydrocephalus (NPH).
Though hydrocephalus citizen situation is not registered by country, the data that draw after through the assessment to some are significant to the assessment of national population.The ramose institute of NIH's neurological disorders and apoplexy estimates, approximately just have among per 500 children 1 congenital ill.And nearest statistical data shows, NPH is exactly the origin of dementia, and 5% people suffers from dementia among patient NPH more than 70 years old.
During diagnosis of cerebral hydrops, most of doctors utilize Cranial Computed Tomography or MRI scanning.On the other hand, monitoring technology mainly comprises invasive method at present, and like monitoring intracranial pressure, waist is worn (LP), or uses and in cerebrospinal fluid, insert the impedance of electrode measurement cerebrospinal fluid.In these programs, a hole is essential, and with assessment intracranial environment, LP can cause that cerebral hernia is dead sometimes.Recently, developed the hydrocephalic technology of non-invasive assessment based on the TCD,transcranial Doppler (TCS) of medical supersonic technology, but said method does not all provide 24 hours bedside monitorings.
Another similar situation, hydrocephalus, cerebral edema.The cerebral edema brain injury, wound and infection etc., may cause expanding behind similar our ankle or the knee injury with redundant moisture from cerebral tissue swelling.Yet unlike our ankle or knee, our brain is to surround thick and hard skull, does not leave enough expansion leeway, thereby causes intracranial pressure to increase.If can't discern with undressed, cerebral edema can cause nonvolatil injury or death., in CICU continuous monitoring hydrocephalus 24 hours every days and cerebral edema, this is desirable method and system in patient's bedside.This system needs cost low, is easy to use, and allows monitoring and minimum of interference automatically.
Summary of the invention
The object of the invention just provides a kind of electric signal process unit that is used to monitor hydrocephalus and cerebral edema; It can be handled the signal of telecommunication that passes through human brain that monitoring device collects; It can use the 24 hours monitoring and evaluation hydrocephaluss of mode of non-invasion and the situation of cerebral edema to cooperate monitoring device, reduces and treats risk.
The objective of the invention is to realize that through such technical scheme it includes collecting electrode, signal processing digital converter, quadrature actuator, detector, parameter evaluation device, electric impedance analyzer and assessment appearance,
Collecting electrode receives the electromagnetic wave that emission electrode sent through human brain;
The signal processing digital converter, the electromagnetic wave that collecting electrode is received amplifies and Filtering Processing, is digital signal with analog signal conversion again;
The quadrature actuator; To the signal of telecommunication orthogonalization process that the signal processing digitizer processes is crossed, obtain signal
Figure 2012100457338100002DEST_PATH_IMAGE002
and orthogonal signalling
Figure 2012100457338100002DEST_PATH_IMAGE004
in the same way;
Detector detects electromagnetic signal in the same way
Figure 46993DEST_PATH_IMAGE002
and orthogonal signalling
Figure 9133DEST_PATH_IMAGE004
;
The parameter evaluation device calculates relative damping coefficient
Figure 2012100457338100002DEST_PATH_IMAGE006
, relative phase shift
Figure 2012100457338100002DEST_PATH_IMAGE008
, propagation time difference and complex wave value K;
Electric impedance analyzer according to the signal of telecommunication that obtains after the signal processing digitizer processes, is measured complex impedance Z and electric capacity;
The assessment appearance, the parameter that obtains according to parameter evaluation device and electric impedance analyzer carries out hydrocephalus and cerebral edema is assessed.
Further, said signal processing converter includes amplification module, first demodulation module, second demodulation module, buffer module and digital module,
Amplification module amplifies the signal of telecommunication that receives through low noise and wideband difference amplifier;
First demodulation module carries out demodulation in frequency range 0 to 50MHZ to the signal of telecommunication after amplifying;
Second demodulation module carries out demodulation in frequency range 50 to 400MHZ to the signal of telecommunication after amplifying;
Buffer module is used to cushion the output signal of first demodulation module;
Digital module is sampled the signal of telecommunication after the demodulation and digitized processing.
Further, the chip used model of said amplification module is LMH6552.
Further, the chip used model of said first demodulation module is AD8333.
Further, the chip used model of said second demodulation module is AD8348.
Further, the chip used model of said buffer module is LTC2061.
Further, the chip used model of said digital module is dsPIC33F.
Further, the parameter evaluation device calculates attenuation quotient
Figure 952075DEST_PATH_IMAGE006
through following formula
Figure 2012100457338100002DEST_PATH_IMAGE012
is propagation distance in the formula;
Figure 2012100457338100002DEST_PATH_IMAGE016
electromagnetic empty ripple for receiving;
Figure 2012100457338100002DEST_PATH_IMAGE018
is the electromagnetic empty ripple of emission, and
Figure 2012100457338100002DEST_PATH_IMAGE020
is the electromagnetic wave angular frequency.
Further, the parameter evaluation device calculates relative phase shift
Figure 569524DEST_PATH_IMAGE008
through following formula
Figure 382628DEST_PATH_IMAGE014
is propagation distance in the formula;
Figure 2012100457338100002DEST_PATH_IMAGE024
electromagnetic phase place for receiving;
Figure 2012100457338100002DEST_PATH_IMAGE026
is the electromagnetic phase place of emission, and
Figure 84261DEST_PATH_IMAGE020
is the electromagnetic wave angular frequency.
Further, the parameter evaluation device calculates propagation time difference
Figure 250800DEST_PATH_IMAGE010
through following formula
Figure 2012100457338100002DEST_PATH_IMAGE028
In the formula;
Figure 2012100457338100002DEST_PATH_IMAGE030
electromagnetic wave propagation speed for receiving,
Figure 2012100457338100002DEST_PATH_IMAGE032
is the electromagnetic wave propagation speed of emission.
Owing to adopted technique scheme, the present invention to have following advantage:
Electromagnetic wave is through behind the human brain; Change has taken place; Through before the comparison electromagnetic wave entering human brain and, can assess the concrete condition of hydrocephalus and cerebral edema through attenuation quotient
Figure 718559DEST_PATH_IMAGE006
, relative phase shift
Figure 637318DEST_PATH_IMAGE008
, propagation time difference
Figure 370788DEST_PATH_IMAGE010
and complex wave value K behind the human brain.The present invention calculates electromagnetic parameter change value through the processing to the signal of telecommunication, cooperates monitoring device, is different from the traditional invasive monitoring method, can realize monitoring in 24 hours, has significantly increased the medical safety property of hydrocephalus and cerebral edema.
Other advantages of the present invention, target and characteristic will be set forth in description subsequently to a certain extent; And to a certain extent; Based on being conspicuous to those skilled in the art, perhaps can from practice of the present invention, obtain instruction to investigating of hereinafter.Target of the present invention and other advantages can realize and obtain through following description and claims.
Description of drawings
Description of drawings of the present invention is following.
Fig. 1 is a structural representation of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing and embodiment the present invention is described further.
Be used to monitor the electric signal process unit of hydrocephalus and cerebral edema, it is characterized in that: said device includes collecting electrode, signal processing digital converter, quadrature actuator, detector, parameter evaluation device, electric impedance analyzer and assessment appearance,
Collecting electrode receives the electromagnetic wave that emission electrode sent through human brain;
The signal processing digital converter, the electromagnetic wave that collecting electrode is received amplifies and Filtering Processing, is digital signal with analog signal conversion again;
The quadrature actuator; To the signal of telecommunication orthogonalization process that the signal processing digitizer processes is crossed, obtain signal
Figure 606597DEST_PATH_IMAGE002
and orthogonal signalling in the same way;
Detector detects electromagnetic signal in the same way
Figure 772185DEST_PATH_IMAGE002
and orthogonal signalling
Figure 933564DEST_PATH_IMAGE004
;
The parameter evaluation device calculates relative damping coefficient
Figure 504222DEST_PATH_IMAGE006
, relative phase shift
Figure 697306DEST_PATH_IMAGE008
, propagation time difference
Figure 898480DEST_PATH_IMAGE010
and complex wave value K;
Electric impedance analyzer according to the signal of telecommunication that obtains after the signal processing digitizer processes, is measured complex impedance Z and electric capacity;
The assessment appearance, the parameter that obtains according to parameter evaluation device and electric impedance analyzer carries out hydrocephalus and cerebral edema is assessed.
Electromagnetic wave changes through human brain, and collecting electrode according to the invention receives the electromagnetic wave after the change, and amplification and Filtering Processing through the signal processing digital converter convert digital signal again to.Digital signal is regulated through the quadrature actuator, detects through the electromagnetic parameter behind the human brain through detector again, and the parameter that the combined impedance analyser obtains is carried out the assessment of hydrocephalus and cerebral edema.
Through the resulting change of the propagation of electromagnetic wave in human brain; The principle that hydrocephalus and cerebral edema are assessed is: dielectric constant that cerebrospinal fluid, alba and ectocinerea are different in the human brain and conductivity; The electric conductivity of cerebrospinal fluid does not have than alba and ectocinerea; The electric medium constant of cerebrospinal fluid is lower than alba and ectocinerea, and electromagnetic wave propagation is relevant with dielectric constant and conductivity, can distinguish cerebrospinal fluid in the human brain through electromagnetic change; Thereby be used for estimating the content of cerebrospinal fluid, carry out the assessment of hydrocephalus and brain water kind.Device according to the invention is non-invasion formula, and it is subcutaneous that emission electrode and collecting electrode only need be positioned at brain.
The present invention can assess the concrete condition of hydrocephalus and cerebral edema through above-mentioned work, is different from the traditional invasive monitoring method, and the present invention can realize monitoring in 24 hours, has significantly increased the medical safety property of hydrocephalus and cerebral edema.The concrete computational methods of its electromagnetic wave parameter are: the parameter evaluation device calculates attenuation quotient through following formula
Figure 2012100457338100002DEST_PATH_IMAGE034
is propagation distance in the formula;
Figure 2012100457338100002DEST_PATH_IMAGE035
electromagnetic empty ripple for receiving;
Figure 2012100457338100002DEST_PATH_IMAGE036
is the electromagnetic empty ripple of emission, and
Figure 337137DEST_PATH_IMAGE020
is the electromagnetic wave angular frequency.
The parameter evaluation device calculates relative phase shift
Figure 2012100457338100002DEST_PATH_IMAGE037
through following formula
Figure 2012100457338100002DEST_PATH_IMAGE038
Figure 899093DEST_PATH_IMAGE014
is propagation distance in the formula;
Figure 94451DEST_PATH_IMAGE024
electromagnetic phase place for receiving;
Figure 210174DEST_PATH_IMAGE026
is the electromagnetic phase place of emission, and
Figure 174588DEST_PATH_IMAGE020
is the electromagnetic wave angular frequency.
The parameter evaluation device calculates propagation time difference
Figure 714635DEST_PATH_IMAGE010
through following formula
In the formula;
Figure 194027DEST_PATH_IMAGE030
electromagnetic wave propagation speed for receiving,
Figure 175758DEST_PATH_IMAGE032
is the electromagnetic wave propagation speed of emission.
Said signal processing converter includes amplification module, first demodulation module, second demodulation module, buffer module and digital module,
Amplification module amplifies the signal of telecommunication that receives through low noise and wideband difference amplifier;
First demodulation module carries out demodulation in frequency range 0 to 50MHZ to the signal of telecommunication after amplifying;
Second demodulation module carries out demodulation in frequency range 50 to 400MHZ to the signal of telecommunication after amplifying;
Buffer module is used to cushion the output signal of first demodulation module;
Digital module is sampled the signal of telecommunication after the demodulation and digitized processing.
Electromagnetic wave is propagated and will be received by electrode through brain, is amplified by low noise and wideband difference amplifier LMH6552.Amplifier signal is the first demodulator AD8333 institute demodulation of 0-50 MHz by frequency range; Be the second demodulator AD8348 institute demodulation of 50 MHz-400 MHz by frequency range then, buffer LTC 2061 is used to cushion the output of the first demodulator AD8333.Two pairs come from the orthogonal signalling I of two different frequency scopes and in the same way signal Q be digitized module dsPIC33F digitized.
Explanation is at last; Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; Although with reference to preferred embodiment the present invention is specified, those of ordinary skill in the art should be appreciated that and can make amendment or be equal to replacement technical scheme of the present invention; And not breaking away from the aim and the scope of present technique scheme, it all should be encompassed in the middle of the claim scope of the present invention.

Claims (10)

1. be used to monitor the electric signal process unit of hydrocephalus and cerebral edema, it is characterized in that: said device includes collecting electrode, signal processing digital converter, quadrature actuator, detector, parameter evaluation device, electric impedance analyzer and assessment appearance,
Collecting electrode receives the electromagnetic wave that emission electrode sent through human brain;
The signal processing digital converter, the electromagnetic wave that collecting electrode is received amplifies and Filtering Processing, is digital signal with analog signal conversion again;
The quadrature actuator; To the signal of telecommunication orthogonalization process that the signal processing digitizer processes is crossed, obtain signal
Figure 2012100457338100001DEST_PATH_IMAGE002
and orthogonal signalling
Figure 2012100457338100001DEST_PATH_IMAGE004
in the same way;
Detector detects electromagnetic signal in the same way
Figure 859623DEST_PATH_IMAGE002
and orthogonal signalling
Figure 573501DEST_PATH_IMAGE004
;
The parameter evaluation device calculates relative damping coefficient
Figure 2012100457338100001DEST_PATH_IMAGE006
, relative phase shift
Figure 2012100457338100001DEST_PATH_IMAGE008
, propagation time difference
Figure 2012100457338100001DEST_PATH_IMAGE010
and complex wave value K;
Electric impedance analyzer according to the signal of telecommunication that obtains after the signal processing digitizer processes, is measured complex impedance Z and electric capacity;
The assessment appearance, the parameter that obtains according to parameter evaluation device and electric impedance analyzer carries out hydrocephalus and cerebral edema is assessed.
2. the electric signal process unit that is used to monitor hydrocephalus and cerebral edema as claimed in claim 1 is characterized in that: said signal processing converter includes amplification module, first demodulation module, second demodulation module, buffer module and digital module,
Amplification module amplifies the signal of telecommunication that receives through low noise and wideband difference amplifier;
First demodulation module carries out demodulation in frequency range 0 to 50MHZ to the signal of telecommunication after amplifying;
Second demodulation module carries out demodulation in frequency range 50 to 400MHZ to the signal of telecommunication after amplifying;
Buffer module is used to cushion the output signal of first demodulation module;
Digital module is sampled the signal of telecommunication after the demodulation and digitized processing.
3. the electric signal process unit that is used to monitor hydrocephalus and cerebral edema as claimed in claim 2 is characterized in that: the chip used model of said amplification module is LMH6552.
4. the electric signal process unit that is used to monitor hydrocephalus and cerebral edema as claimed in claim 2 is characterized in that: the chip used model of said first demodulation module is AD8333.
5. the electric signal process unit that is used to monitor hydrocephalus and cerebral edema as claimed in claim 2 is characterized in that: the chip used model of said second demodulation module is AD8348.
6. the electric signal process unit that is used to monitor hydrocephalus and cerebral edema as claimed in claim 2 is characterized in that: the chip used model of said buffer module is LTC2061.
7. the electric signal process unit that is used to monitor hydrocephalus and cerebral edema as claimed in claim 2 is characterized in that: the chip used model of said digital module is dsPIC33F.
8. like claim 1,2,3,4,5, the 6 or 7 described electric signal process units that are used to monitor hydrocephalus and cerebral edema, it is characterized in that: the parameter evaluation device calculates attenuation quotient
Figure 933332DEST_PATH_IMAGE006
through following formula
Figure 2012100457338100001DEST_PATH_IMAGE012
Figure 2012100457338100001DEST_PATH_IMAGE014
is propagation distance in the formula;
Figure 2012100457338100001DEST_PATH_IMAGE016
electromagnetic empty ripple for receiving;
Figure 2012100457338100001DEST_PATH_IMAGE018
is the electromagnetic empty ripple of emission, and
Figure 2012100457338100001DEST_PATH_IMAGE020
is the electromagnetic wave angular frequency.
9. like claim 1,2,3,4,5, the 6 or 7 described electric signal process units that are used to monitor hydrocephalus and cerebral edema, it is characterized in that: the parameter evaluation device calculates relative phase shift
Figure 824147DEST_PATH_IMAGE008
through following formula
Figure 2012100457338100001DEST_PATH_IMAGE022
Figure 497573DEST_PATH_IMAGE014
is propagation distance in the formula;
Figure 2012100457338100001DEST_PATH_IMAGE024
electromagnetic phase place for receiving; is the electromagnetic phase place of emission, and
Figure 834883DEST_PATH_IMAGE020
is the electromagnetic wave angular frequency.
10. like claim 1,2,3,4,5, the 6 or 7 described electric signal process units that are used to monitor hydrocephalus and cerebral edema, it is characterized in that: the parameter evaluation device calculates propagation time difference
Figure 167162DEST_PATH_IMAGE010
through following formula
Figure 2012100457338100001DEST_PATH_IMAGE028
In the formula; electromagnetic wave propagation speed for receiving,
Figure 2012100457338100001DEST_PATH_IMAGE032
is the electromagnetic wave propagation speed of emission.
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CN103110408A (en) * 2013-03-14 2013-05-22 重庆大学 Encephaledema monitoring device
CN104783794A (en) * 2015-04-15 2015-07-22 重庆博恩富克医疗设备有限公司 Method and device for processing electromagnetic wave signals

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