CN102525458B - Device for monitoring hydrocephalus and encephaledema - Google Patents

Device for monitoring hydrocephalus and encephaledema Download PDF

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CN102525458B
CN102525458B CN 201210045721 CN201210045721A CN102525458B CN 102525458 B CN102525458 B CN 102525458B CN 201210045721 CN201210045721 CN 201210045721 CN 201210045721 A CN201210045721 A CN 201210045721A CN 102525458 B CN102525458 B CN 102525458B
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electromagnetic wave
signal
electromagnetic
hydrocephalus
emission
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郑翊
蒋辉
吴琪
胡少雄
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CHONGQING BOEN FUKE MEDICAL EQUIPMENT Co Ltd
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Abstract

The invention relates to a device for monitoring hydrocephalus and encephaledema. The device comprises a signal encoding generator, an emitting electrode, a receiving electrode, a signal processing digital converter, an orthogonality regulator, a detector, a parameter evaluator, an impedance analysis instrument and an evaluation instrument. After passing through the human brain, electromagnetic waves change, by comparing attenuation coefficients, relative phase shifts, spreading time differences and complex wave values K of the electromagnetic waves before and after the electromagnetic waves enter the human brain, the specific conditions of the hydrocephalus and encephaledema be can evaluated, the method is different from the traditional invasion detection method, the device can be used for realizing 24-hour monitoring, so that the medical safety in treatment of hydrocephalus and encephaledema is obviously improved.

Description

The device that is used for monitor cerebral hydrops and cerebral edema
Technical field
The present invention relates to a kind of medical apparatus and instruments, particularly the hydrocephalic medical apparatus and instruments of a kind of monitoring.
Background technology
The condition that hydrocephalus is known is at encephalocoele or the ventricles of the brain, the excessive buildup of cerebrospinal fluid (CSF).Under normal circumstances, cerebrospinal fluid is that the running of brain is most important.Carry nutrient and refuse from brain, and create the neonychium of a liquid.But the excessive accumulation of cerebrospinal fluid is to the disproportionate pressure of brain, and may cause brain cell and tissue injury.Therefore, medical condition, the absorption of directly interrupting cerebrospinal fluid enters the proper flow of blood and creates cerebrospinal fluid too much, finally causes hydrocephalus.
Human potential and classification that hydrocephalus affects institute's has age can be divided into two large classes: obtain congenital hydrocephalus and the day after tomorrow hydrops.Congenital hydrocephalus is when birth, can be in the gene unconventionality of the growth and development stage of fetus, premature labor, or the result of impact.By contrast, obtaining hydrops the day after tomorrow is that some body reason pathological changes of people causes, but is not limited only to angiopathy, injury of head or injury of head.Cause adult's apoplexy, hemorrhage, or the hydrops of these two categories of brain trauma, be called as ultravacuum hydrocephalus and normal pressure hydrocephalus (NPH).
Although hydrocephalus citizen situation is not registered by country, the data that draw after by the assessment to some are significant to the assessment of national population.The institute of NIH's neurological disorders and apoplexy branch estimates, approximately just have in every 500 children 1 congenital ill.And nearest statistical data shows, NPH is exactly the origin of dementia, and in patient NPH more than 70 years old, 5% people suffers from dementia.
During the diagnosis hydrocephalus, most of doctors utilize Cranial Computed Tomography or MRI scanning.On the other hand, monitoring technology mainly comprises invasive method at present, and as monitoring intracranial pressure, waist is worn (LP), or uses electrode insertion measurement cerebrospinal fluid impedance in cerebrospinal fluid.In these programs, a hole is essential, and with assessment intracranial environment, LP can cause that cerebral hernia is dead sometimes.Recently, developed the hydrocephalic technology of non-invasive assessment based on the TCD,transcranial Doppler (TCS) of medical supersonic technology, but said method does not all provide 24 hours bedside monitorings.
Another similar situation, hydrocephalus, cerebral edema.The cerebral edema brain injury, wound and infection etc., may cause similar we ankle or knee injury after expand with unnecessary moisture from cerebral tissue swelling.Yet unlike our ankle or knee, our brain is to surround thick and hard skull, does not leave enough expansion leeway, thereby causes intracranial pressure to increase.If None-identified and undressed, cerebral edema can cause permanent injury or death., in intensive care unit(ICU) continuous monitoring hydrocephalus 24 hours every days and cerebral edema, this is desirable method and system at patient's bedside.This system needs cost low, is easy to use, and allows monitoring and minimum of interference automatically.
Summary of the invention
Purpose of the present invention just is to provide a kind of device for monitor cerebral hydrops and cerebral edema, can use 24 hours monitoring and evaluation hydrocephaluss of mode of non-invasion and the situation of cerebral edema by it, reduces Operative risk.
The objective of the invention is to realize by such technical scheme, it includes Signal coding generator, emission electrode, collecting electrode, signal processing digital converter, Orthogonal modification device, detector, parameter evaluation device, electric impedance analyzer and assessment instrument,
The Signal coding generator is used for generating electromagnetic wave, and the initial amplitude of recording electromagnetic wave
Figure 2012100457215100002DEST_PATH_IMAGE002
And initial phase
Figure 2012100457215100002DEST_PATH_IMAGE004
Emission electrode, transmitting to encode to human brain, the electromagnetic wave of generation occurs;
Collecting electrode receives the electromagnetic wave that the emission electrode by human brain sends;
The signal processing digital converter, the electromagnetic wave that collecting electrode is received amplifies and Filtering Processing, then is digital signal with analog signal conversion;
The Orthogonal modification device, the signal of telecommunication orthogonalization process to the signal processing digitizer processes is crossed obtains signal in the same way
Figure 2012100457215100002DEST_PATH_IMAGE006
And orthogonal signalling
Figure 2012100457215100002DEST_PATH_IMAGE008
Detector detects electromagnetic signal in the same way
Figure 691344DEST_PATH_IMAGE006
And orthogonal signalling
The parameter evaluation device calculates relative damping coefficient
Figure 2012100457215100002DEST_PATH_IMAGE010
, relative phase shift , propagation time difference
Figure 2012100457215100002DEST_PATH_IMAGE014
With complex wave value K;
Electric impedance analyzer according to the signal of telecommunication that obtains after the signal processing digitizer processes, is measured complex impedance Z and electric capacity;
The assessment instrument carries out hydrocephalus and cerebral edema assessment according to the parameter that parameter evaluation device and electric impedance analyzer obtain.
Further, the parameter evaluation device passes through following formula to attenuation quotient Calculate
Figure 2012100457215100002DEST_PATH_IMAGE016
In formula
Figure 2012100457215100002DEST_PATH_IMAGE018
Be propagation distance, Be the electromagnetic empty ripple that receives,
Figure 2012100457215100002DEST_PATH_IMAGE022
Be the electromagnetic empty ripple of emission,
Figure 2012100457215100002DEST_PATH_IMAGE024
Be the electromagnetic wave angular frequency.
Further, the parameter evaluation device passes through following formula to relative phase shift
Figure 976197DEST_PATH_IMAGE012
Calculate
Figure 2012100457215100002DEST_PATH_IMAGE026
In formula
Figure 183800DEST_PATH_IMAGE018
Be propagation distance,
Figure 2012100457215100002DEST_PATH_IMAGE028
Be the electromagnetic phase place that receives,
Figure 725771DEST_PATH_IMAGE004
Be the electromagnetic phase place of emission,
Figure 742269DEST_PATH_IMAGE024
Be the electromagnetic wave angular frequency.
Further, the parameter evaluation device passes through following formula to propagation time difference
Figure 177929DEST_PATH_IMAGE014
Calculate
Figure 2012100457215100002DEST_PATH_IMAGE030
In formula,
Figure 2012100457215100002DEST_PATH_IMAGE032
Be the electromagnetic wave propagation speed that receives, Electromagnetic wave propagation speed for emission.
Further, the electromagnetic wave that produces of described Signal coding generator includes the coding ripple of continuous monochromatic, multi-frequency wideband pulse and assigned frequency and wave mode.
Further, to be positioned at brain subcutaneous for described emission electrode and collecting electrode.
Owing to having adopted technique scheme, the present invention has advantages of as follows:
Change has occured by after human brain in electromagnetic wave, by before relatively electromagnetic wave enters human brain and by the attenuation quotient after human brain
Figure 635062DEST_PATH_IMAGE010
, relative phase shift
Figure 461067DEST_PATH_IMAGE012
, propagation time difference With complex wave value K, can assess the concrete condition of hydrocephalus and cerebral edema, be different from the traditional invasive monitoring method, the present invention can realize monitoring in 24 hours, has significantly increased the medical safety of hydrocephalus and cerebral edema.
Other advantages of the present invention, target and feature will be set forth to a certain extent in the following description, and to a certain extent, based on being apparent to those skilled in the art to investigating hereinafter, perhaps can be instructed from the practice of the present invention.Target of the present invention and other advantages can realize and obtain by following description and claims.
Description of drawings
Description of drawings of the present invention is as follows.
Fig. 1 is structural representation of the present invention.
The specific embodiment
The invention will be further described below in conjunction with drawings and Examples.
Be used for the device of monitor cerebral hydrops and cerebral edema, described device includes Signal coding generator, emission electrode, collecting electrode, signal processing digital converter, Orthogonal modification device, detector, parameter evaluation device, electric impedance analyzer and assessment instrument,
The Signal coding generator is used for generating electromagnetic wave, and the initial amplitude of recording electromagnetic wave
Figure 571422DEST_PATH_IMAGE002
And initial phase
Figure 451654DEST_PATH_IMAGE004
Emission electrode, transmitting to encode to human brain, the electromagnetic wave of generation occurs;
Collecting electrode receives the electromagnetic wave that the emission electrode by human brain sends;
The signal processing digital converter, the electromagnetic wave that collecting electrode is received amplifies and Filtering Processing, then is digital signal with analog signal conversion;
The Orthogonal modification device, the signal of telecommunication orthogonalization process to the signal processing digitizer processes is crossed obtains signal in the same way
Figure 785462DEST_PATH_IMAGE006
And orthogonal signalling
Figure 143762DEST_PATH_IMAGE008
Detector detects electromagnetic signal in the same way
Figure 554015DEST_PATH_IMAGE006
And orthogonal signalling
Figure 605148DEST_PATH_IMAGE008
The parameter evaluation device calculates relative damping coefficient , relative phase shift
Figure 567736DEST_PATH_IMAGE012
, propagation time difference
Figure 501669DEST_PATH_IMAGE014
With complex wave value K;
Electric impedance analyzer according to the signal of telecommunication that obtains after the signal processing digitizer processes, is measured complex impedance Z and electric capacity;
The assessment instrument carries out hydrocephalus and cerebral edema assessment according to the parameter that parameter evaluation device and electric impedance analyzer obtain.
The present invention generates electromagnetic waves by the Signal coding generator, emission electrode sends electromagnetic wave, and electromagnetic wave changes by human brain, and collecting electrode receives the electromagnetic wave after changing, by amplification and the Filtering Processing of signal processing digital converter, then convert digital signal to.Digital signal is regulated through the Orthogonal modification device, then detects by the electromagnetic parameter after human brain by detector, and the parameter that the combined impedance analyser obtains is carried out the assessment of hydrocephalus and cerebral edema.
The resulting change of propagation by electromagnetic wave in human brain, the principle that hydrocephalus and cerebral edema are assessed is: the dielectric constant that in human brain, cerebrospinal fluid, alba and ectocinerea are different and conductivity, the electric conductivity of cerebrospinal fluid does not have than alba and ectocinerea, the electric medium constant of cerebrospinal fluid is lower than alba and ectocinerea, electromagnetic wave propagation is relevant to dielectric constant and conductivity, can distinguish cerebrospinal fluid in human brain by electromagnetic change, thereby be used for estimating the content of cerebrospinal fluid, carry out the assessment of hydrocephalus and brain water kind.Device of the present invention is non-invasion formula, and it is subcutaneous that emission electrode and collecting electrode only need be positioned at brain.
The electromagnetic wave that described Signal coding generator produces includes the coding ripple of continuous monochromatic, multi-frequency wideband pulse and assigned frequency and wave mode.
The present invention can assess the concrete condition of hydrocephalus and cerebral edema by above-mentioned work, is different from the traditional invasive monitoring method, and the present invention can realize monitoring in 24 hours, has significantly increased the medical safety of hydrocephalus and cerebral edema.Its circular is as follows:
The parameter evaluation device passes through following formula to attenuation quotient
Figure 723703DEST_PATH_IMAGE010
Calculate
In formula
Figure 977278DEST_PATH_IMAGE018
Be propagation distance,
Figure 96544DEST_PATH_IMAGE020
Be the electromagnetic empty ripple that receives,
Figure 223900DEST_PATH_IMAGE022
Be the electromagnetic empty ripple of emission,
Figure 58476DEST_PATH_IMAGE024
Be the electromagnetic wave angular frequency.
The parameter evaluation device passes through following formula to relative phase shift
Figure 499953DEST_PATH_IMAGE012
Calculate
Figure 739304DEST_PATH_IMAGE026
In formula
Figure 37562DEST_PATH_IMAGE018
Be propagation distance,
Figure 362364DEST_PATH_IMAGE028
Be the electromagnetic phase place that receives,
Figure 607531DEST_PATH_IMAGE004
Be the electromagnetic phase place of emission,
Figure 432880DEST_PATH_IMAGE024
Be the electromagnetic wave angular frequency.
The parameter evaluation device passes through following formula to propagation time difference
Figure 167618DEST_PATH_IMAGE014
Calculate
Figure 714137DEST_PATH_IMAGE030
In formula,
Figure 762996DEST_PATH_IMAGE032
Be the electromagnetic wave propagation speed that receives, Electromagnetic wave propagation speed for emission.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although with reference to preferred embodiment, the present invention is had been described in detail, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement technical scheme of the present invention, and not breaking away from aim and the scope of the technical program, it all should be encompassed in the middle of claim scope of the present invention.

Claims (5)

1. be used for the device of monitor cerebral hydrops and cerebral edema, it is characterized in that: described device includes Signal coding generator, emission electrode, collecting electrode, signal processing digital converter, Orthogonal modification device, detector, parameter evaluation device, electric impedance analyzer and assessment instrument
The Signal coding generator is used for generating electromagnetic wave, and the initial amplitude of recording electromagnetic wave
Figure DEST_PATH_IMAGE002
And initial phase
Figure DEST_PATH_IMAGE004
Emission electrode is to the human brain electromagnetic wave that code generator produces that transmits;
Collecting electrode receives the electromagnetic wave that the emission electrode by human brain sends;
The signal processing digital converter, the electromagnetic wave that collecting electrode is received amplifies and Filtering Processing, then is digital signal with analog signal conversion;
The Orthogonal modification device, the signal of telecommunication orthogonalization process to the signal processing digitizer processes is crossed obtains signal in the same way
Figure DEST_PATH_IMAGE006
And orthogonal signalling
Figure DEST_PATH_IMAGE008
Detector detects electromagnetic signal in the same way
Figure 707516DEST_PATH_IMAGE006
And orthogonal signalling
Figure 562339DEST_PATH_IMAGE008
The parameter evaluation device calculates relative damping coefficient
Figure DEST_PATH_IMAGE010
, relative phase shift , propagation time difference
Figure DEST_PATH_IMAGE014
With complex wave value K;
Electric impedance analyzer according to the signal of telecommunication that obtains after the signal processing digitizer processes, is measured complex impedance Z and electric capacity;
The assessment instrument carries out hydrocephalus and cerebral edema assessment according to the parameter that parameter evaluation device and electric impedance analyzer obtain;
The electromagnetic wave that described Signal coding generator produces includes the coding ripple of continuous monochromatic, multi-frequency wideband pulse and assigned frequency and wave mode.
2. the device for monitor cerebral hydrops and cerebral edema as claimed in claim 1 is characterized in that: the parameter evaluation device by following formula to attenuation quotient
Figure 466710DEST_PATH_IMAGE010
Calculate
Figure DEST_PATH_IMAGE016
In formula Be propagation distance,
Figure DEST_PATH_IMAGE020
Be the electromagnetic empty ripple that receives,
Figure DEST_PATH_IMAGE022
Be the electromagnetic empty ripple of emission,
Figure DEST_PATH_IMAGE024
Be the electromagnetic wave angular frequency.
3. the device for monitor cerebral hydrops and cerebral edema as claimed in claim 1 is characterized in that: the parameter evaluation device by following formula to relative phase shift
Figure 819561DEST_PATH_IMAGE012
Calculate
Figure DEST_PATH_IMAGE026
In formula
Figure 820884DEST_PATH_IMAGE018
Be propagation distance,
Figure DEST_PATH_IMAGE028
Be the electromagnetic phase place that receives,
Figure 581030DEST_PATH_IMAGE004
Be the electromagnetic phase place of emission, Be the electromagnetic wave angular frequency.
4. as claim 1,2 or 3 described devices for monitor cerebral hydrops and cerebral edema, it is characterized in that: the parameter evaluation device passes through following formula to propagation time difference
Figure 233914DEST_PATH_IMAGE014
Calculate
Figure DEST_PATH_IMAGE030
In formula,
Figure DEST_PATH_IMAGE032
Be the electromagnetic wave propagation speed that receives,
Figure DEST_PATH_IMAGE034
Electromagnetic wave propagation speed for emission.
5. the device for monitor cerebral hydrops and cerebral edema as claimed in claim 1, it is characterized in that: it is subcutaneous that described emission electrode and collecting electrode are positioned at brain.
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CN103110408A (en) * 2013-03-14 2013-05-22 重庆大学 Encephaledema monitoring device
CN104257382B (en) * 2014-09-11 2016-06-29 东北大学 Biological tissue's electromagnetic parameter imaging device and method based on propagation velocity of electromagnetic wave
CN104720800B (en) * 2015-04-15 2017-10-10 重庆博恩富克医疗设备有限公司 A kind of electromagnetic wave signal processing unit
CN105769190B (en) * 2016-03-29 2018-12-21 重庆大学 A kind of device detected for cephalophyma, brain edema
CN106603107B (en) * 2016-12-21 2019-10-29 Tcl移动通信科技（宁波）有限公司 A kind of helmet and its control method
CN109363631A (en) * 2018-07-27 2019-02-22 河北大艾智能科技股份有限公司 A kind of tissue health monitor method, terminal device and system

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