CN1416863A - 一种治疗皮肤病的外用药 - Google Patents
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Abstract
一种治疗皮肤病的外用药，是采用青藏高原2500米以上的传统藏药：烈香杜鹃精油、猪毛蒿精油、苦参根，运用现代科技精制而成的乳化剂。本发明适用于各种皮肤病，对皮肤深部霉菌具有较强的抑制作用，无刺激、无副作用，保湿性强，易于渗透到皮下。尤其对妇科疾病有显著的疗效。
Description
技术领域
本发明涉及一种治疗皮肤病的外用药。
背景技术
病理学研究证明，皮肤病大多为局部病变，一般由霉菌感染所致。根据皮肤病变的部位不同，可分为浅部霉菌病和深部霉菌病，浅部霉菌一般由癣菌所引起，主要是侵犯表皮的角质层，深部霉菌变累及皮肤深部组织和心、肺、消化道等内脏器官。白色念珠菌为深部霉菌，引起浅表皮肤和粘膜感染，如女阴及阴道等疾病。目前市面上出售的治疗由癣菌引起的深部霉菌外用药虽然疗效较好，但均易产生耐药菌珠，对病菌的抑制率低，洗液、挤型使用不便，且大部分具有酸、碱性，对皮肤有刺激作用。
发明内容
本发明的目的在于提供一种纯植物的治疗皮肤深部霉菌的外用药。
本发明通过以下方式实现：治疗皮肤病的外用药的原料含量为：烈香杜鹃精油0.01-10g、猪毛蒿精油0.01-10g、苦参1-200g。
所述的治疗皮肤病的外用药的制备工艺：取烈香杜鹃嫩枝叶、猪毛蒿全草切成寸段，分别加入蒸馏锅内，水加热蒸馏，收集馏出液，油水分离，得精油原料，备用，苦渗根、切成饮片或粉碎成3-10目粗粉，50％酸性乙醇回流3次，每次2-4小时，合并提取液，减压回收乙醇，浓缩到投料量与浓缩液重量比为1小时，静直，折出树脂状杂质，过滤、滤液浓缩至稠膏，将上述三种原料，按制剂处方计量，再加入增溶剂等，乳化，即得。
本发明的治疗皮肤病的外用药，可直接作用于患处，无刺激，保湿性强，易于渗透到皮下，对由真菌引起的皮肤病、阴道炎、妇科疾病有显著的疗效。
实施方式
下面结合实施例对本发明作进一步说明。
采集烈香杜鹃新鲜嫩枝叶、采集8月至9月猪毛蒿地上部分，并切成寸段，分别加入蒸馏锅内，加入三分之一体积水，加热蒸馏，收集馏出液，油水分离，得精油原料备用，苦参根，切成饮片，50％酸性乙醇(PH＝4)回流提取3次，每次3小时，合并提出液，碱调PH＝6，减压回收乙醇，浓缩到投料量与浓缩液比重比为1小时，静止，折出树枝状杂质，过滤，滤液浓缩至稠膏，将上述三种原料，按处方计量，再加入增溶剂等，乳化、检验、分装、装盒、装箱即得。
烈香杜鹃精油：折光率(n)＝1.506-1.514，比重(d)＝0.925-0.980，以生长于青藏高原海泼2580米以上的杜鹃化料植物烈香杜鹃的嫩叶经水蒸汽蒸馏制备而成。精油中的主要化学成分为r-芹子烯占精油的20％-25％，d-柠檬烯占0.2％，香叶烯占0.4％，杜鹃烯占精油的10-20％，杜鹃次烯占精油2％，d-芹子烯占1％，K-芹子烯占7％，牻牛儿酮占5％，桧脑占3％，苄茎丙酮占精油40-50％。
猪毛蒿精油折光率(n20)＝1.510-1.520，比重(n20)＝0.933-0.935。是菊科蒿属草本植物猪毛蒿8-9月的全草，经水蒸汽蒸馏制备而成。。精油中的主要化学成分为1，8-桉叶油素占精油的20-21％，蒿酮占13-14％，丁香粉占3-4％，丁香粉甲醚占4-5％，其中茵陳炔及茵陈炔酮为中要抑制成分。茵陈炔酮具有很强的抗菌作用，尤其对皮肤病原性状丝状菌作用强大，对白色念珠菌有明显的抑制作用。
苦参碱粗品是从豆料植物苦参的根茎部分经提取、冷沉、除杂而得。苦参碱有多种生理活性，如抗肿瘤、抗心律失常等。同时具有抗炎、抑菌和镇病作用，外用主要用于治疗妇女阴道疾病。
Claims (3)
1.治疗皮肤病的外用药，其特征在于它的原料含量为：烈香杜鹃精油0.01-10g、猪毛蒿精油0.01-10g、苦参1-200g。
2.根据权利要求1所述的治疗皮肤病的外用药物，其特征还在于其原料重量份数优选为：烈香杜鹃精油5g、猪毛蒿精油5g、苦参20g。
3、一种权利要求1所述的治疗皮肤病的外用药的制备工艺：取烈香杜鹃嫩叶、猪毛蒿全草切成寸段，分别加入蒸馏锅内，加热蒸馏，收集馏出液，油水分离，得精油原料；苦参根，切成饮片或粉碎成3-10目粗粉，50％酸性乙醇回流提取3次，每次2-4小时，合并提取液，减压回收乙醇，浓缩到投料量与浓缩液重量比为1小时，静止，折出树枝状杂质，过滤，滤液浓缩至稠膏，将上述三种原料按制剂处方计量，再加入增溶剂等，乳化，即得。
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| CN1416863A true CN1416863A (zh) | 2003-05-14 |
| CN100455307C CN100455307C (zh) | 2009-01-28 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100382781C (zh) * | 2005-01-21 | 2008-04-23 | 西藏宇妥藏药研究有限公司 | 一种藏药浴散剂的制备方法及其质量控制方法 |
| CN108663472A (zh) * | 2018-04-20 | 2018-10-16 | 国药集团德众（佛山）药业有限公司 | 烈香杜鹃精油的鉴定方法 |
| CN108693295A (zh) * | 2018-04-20 | 2018-10-23 | 国药集团德众（佛山）药业有限公司 | 猪毛蒿精油的鉴定方法 |
| CN110585418A (zh) * | 2018-06-13 | 2019-12-20 | 广州合伊美生物科技有限公司 | 女性外用消毒精油乳及其生产工艺 |
| CN112972516A (zh) * | 2021-02-25 | 2021-06-18 | 河南比福制药股份有限公司 | 一种用于外耳道炎的消毒产品 |
-
2002
- 2002-11-06 CN CNB021474923A patent/CN100455307C/zh not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100382781C (zh) * | 2005-01-21 | 2008-04-23 | 西藏宇妥藏药研究有限公司 | 一种藏药浴散剂的制备方法及其质量控制方法 |
| CN108663472A (zh) * | 2018-04-20 | 2018-10-16 | 国药集团德众（佛山）药业有限公司 | 烈香杜鹃精油的鉴定方法 |
| CN108693295A (zh) * | 2018-04-20 | 2018-10-23 | 国药集团德众（佛山）药业有限公司 | 猪毛蒿精油的鉴定方法 |
| CN110585418A (zh) * | 2018-06-13 | 2019-12-20 | 广州合伊美生物科技有限公司 | 女性外用消毒精油乳及其生产工艺 |
| CN112972516A (zh) * | 2021-02-25 | 2021-06-18 | 河南比福制药股份有限公司 | 一种用于外耳道炎的消毒产品 |
| CN112972516B (zh) * | 2021-02-25 | 2022-05-10 | 河南比福制药股份有限公司 | 一种用于外耳道炎的消毒产品 |
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Addressee: Yi Jidong Document name: Notice of publication of application for patent for invention |
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Addressee: Yi Jidong Document name: Notification before expiration of term |
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Addressee: Yi Jidong Document name: Notice of first review |
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Owner name: QINGHAI PULANTE MEDICINE CO., LTD. Free format text: FORMER OWNER: YI JIDONG Effective date: 20090403 |
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Effective date of registration: 20090403 Address after: No. 2, Dongxin Road, Xining economic and Technological Development Zone, Qinghai Patentee after: QINGHAI PLATEAU PHARMACEUTICAL Co.,Ltd. Address before: Qinghai Plante Pharmaceutical Co., Ltd., 2 Dong Xin Lu, Qinghai, Xining Province, China: 810007 Patentee before: Yi Jidong |
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Granted publication date: 20090128 |
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