CN1412559A - Equipment and method for detecting liquid fluid - Google Patents
Equipment and method for detecting liquid fluid Download PDFInfo
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- CN1412559A CN1412559A CN 01137001 CN01137001A CN1412559A CN 1412559 A CN1412559 A CN 1412559A CN 01137001 CN01137001 CN 01137001 CN 01137001 A CN01137001 A CN 01137001A CN 1412559 A CN1412559 A CN 1412559A
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Abstract
The equipment for simplifying sampling process and detecting liquid fluid, minimizing pollution and inhibiting bacterial growth includes a pointed end, a container, a regulating device which is connected with said container and is flexible, said regulating device and the container are formed into an opened continuous compartment, and a mobile member which is placed in the container and mechanically acted by regulating device. Said invention also relates to a method for simplifying sampling and detecting fluid.
Description
Invention field
The present invention relates to sampling and test fluid, especially detect the equipment of the simplification that microorganism exists in the body fluid, be applicable to one-handed performance, and the danger of polluting can be reduced to minimum, for example can reduce growth on the unwelcome bacterium of equipment appearance.This equipment comprises a tip, a container, basically seal softness that links to each other and the regulating device that can rebound with described container, this regulating device and described container have formed the continuous compartment with an opening, with a movable member, this movable member places in the described container, has an active surface of detecting.
The present invention relates to the method that there is the simplification of sampling down and test fluid in microorganism simultaneously, and is relevant with pollution by this method, and for example the problem of unwelcome bacterial growth can reduce to minimum.
Background technology
Owing to numerous reasons detect and analyze body fluid, for example detect the existence of microorganism in the body fluid, existing and still have very important clinical meaning for a long time, for example to the detection and the monitoring of numerous pathological states.For example, urine analysis be exactly a kind of in clinical medicine ancient, the easiest and the most widely used laboratory detection means.With regard to body fluid, described detection can have very important value to the antibiotic of seeking suitable specified conditions.
These detect relatively complicated, generally include a lot of steps, and wherein some step is under microorganism and state that surrounding environment is more or less separated, and microorganism is moved to another place from one.For the processing of microorganism, for example, during detection in the process of hatching and cultivating, owing to much be cause of disease in the microorganism of research, the experimenter has the danger that is infected when detecting.So, developed the analyzing liquid sample of simplifying, there was the equipment of (for example bacterium) in microorganism during for example detection was urinated.These checkout equipments have significantly reduced the testing staff simultaneously and have been exposed to possibility and the contaminated danger of sample in operating process in the microorganism.
Therefore, US 4 054 491 has described equipment and the method that detects the sample that may contain microorganism, in this method and apparatus, sample is mixed with growth of microorganism nutrient culture media and the indication indicator of choosing wantonly, this potpourri detects the existence of the bacterium colony of wherein growing after hatching.Sample at first is added in this equipment by the effect of piston, and growth medium is added in the equipment in the same way then, and the mixing of sample and medium is finished in equipment.Equipment provides transparent part for observing bacterium colony.
In WO9842821, a kind of equipment with detection urine sample of one or more detection dishes has been described, these detection dishes are coated with nutrient culture media and optional antibiotic.In use, the spout of equipment immerses and fills in the disposable glass or similar containers of urine sample, forms low pressure by piston motion in equipment then, utilizes this low pressure with the cylindricality jar of urine sample by the spout inhalation device.Behind the moistening detection dish of urine sample, discharge urine sample from described cylindricality jar, equipment is put into incubator and is cultivated.
When utilizing the checkout equipment of prior art, the urine of detection, or other liquid samples will unavoidably contact the outside with pollution detection equipment, may cause undesirable bacterial growth on described outside surface.Simultaneously, the liquid sample that needs relatively large amount volume.In addition, in practicality, existing equipment can only two manual manipulations.In addition, the most advanced and sophisticated of equipment can only reach small amount of liquid in the detector tube than weak point usually in the prior art.
Therefore, there is the equipment of microorganism stream in one of purpose of the present invention with regard to the detection that provides a kind of energy one-handed performance.
Utilize the equipment of claim 1 to achieve this end, it comprises:
A) tip, it has first and second openings,
B) have the container of an opening, this opening can link to each other with first opening at tip,
C) in the described container of emptying air and move the movable member place described container regulating device and
D) place the movable member of described container, comprise the first that points to opening, second portion and detect the surface.
Described regulating device is soft and can rebounds that link to each other with described container, described regulating device and container have formed the continuous compartment that an opening is arranged, and the second portion of described movable member can be by described regulating device mechanical effect.
Another object of the present invention is the method that the detection and the analysis of simplification are provided according to claim 12, this method can the tracer liquid sample in the existence of microorganism, this method comprises step:
A) provide the sampling and the equipment of tracer liquid, comprising:
A) tip, it has first and second openings; B) have the container of an opening, this opening can link to each other with first opening at tip; C) link to each other with described container soft and the regulating device that can rebound, it is used in the described container of emptying movable member in the air and mobile containers, described regulating device and container formed continuous compartment that an opening is arranged and; D) place the movable member of described container, comprise the first that points to opening, the second portion of described regulating device mechanical effect and detect the surface,
B) make regulating device be in first order compressive state,
C) discharge regulating device from first order compressive state, thereby described movable member keeps its original uncompressed state.
By the following description and the appended claims, embodiment of the present invention and advantage are to understand easily.
Summary of the invention
Equipment of the present invention is that the existence of microorganism in the tracer liquid is provided convenience.Simultaneously, there are not piston or plunger that device structure is more simplified.According to another embodiment of the invention, this equipment has a detachable tip, thereby make and pollute and the dangerous significantly decline of undesirable bacterial growth that this danger mainly is because the part of device outer surface contacts caused with this liquid when sampling contains the testing liquid of microorganism.According to further embodiment, by the movable member that detects the surface is arranged in the mobile containers, opening that can airtight container.In described embodiment, the movable member that places container must be mechanical effect at least, and this movable member also can be conditioned the device promotion when regulating device is compressed to the further compressive state in the second level, or preferably when further compressing, first order compressive state is pushed in regulating device.
According to the present invention, the further compressive state in the second level is fully or the complete state of compression basically preferably.
From the angle of producing, the relative simple structure of present device has also reduced production cost, makes used different part numbers reduce to minimum.Simultaneously, the required quantity of material of constitution equipment seldom.
By moving the movable member that places container, present device can remove detachable tip.This moving process is finished by the regulating device of gas booster compressor.In described embodiment, placing the movable member in the container must be mechanical effect at least, and this movable member can be conditioned the device promotion when regulating device is compressed to the further compressive state in the second level, or preferably when further compressing, first order compressive state is pushed in regulating device.
The tip of equipment can be long, can conveniently be used for test tube like this.
There are not piston or plunger can eliminate the problem relevant with stick-slip phenomenon; these problems have in the prior art that regular meeting runs in the equipment of piston or plunger; for example these equipment in incubation because high-temperature induction; or because the surface of contact of piston and inhomogeneous moistening these problems that caused of container can be eliminated other any problem that runs into when piston uses simultaneously.
The container of described equipment provides translucent at least part, outer can the observing by this part of slave unit places the container movable member to detect upward any visible result of surface like this, as the situation after the microbe culture, or the variation after on this detection surface the expection chemical reaction taking place.Preferred entire container is all made by this translucent at least material.
In addition, according to the present invention, bigger detection surface can be settled in the space that piston or plunger occupy in prior art equipment.Like this, detecting surface area increases with the container volume ratio.Place the movable member of container to determine to detect surperficial area.Therefore, the present invention also helps abundant wetting detection surface and use less liquid sample in whole testing process.
According to the preferred embodiment of the invention, the tip is dismountable, so equipment overall contaminated area after measuring liquid sample can obviously reduce or in fact elimination.
According to the preferred embodiment of the invention, the tip can be removed by the regulating device on the extrusion equipment axial direction, as only using thumb press.In the equipment of grasping, can remove the tip easily with the thumb press of this hand.In addition and since without the contact tip outside with regard to removable should the tip, be bonded at the danger that the liquid that contains microorganism of this outside, tip is transferred because of carelessness like this and be reduced to minimum.The tip can abandon or clean as required the back repeated use then.
According to an embodiment of the present invention, because the further boil down to of regulating device second level state, the tip is removed, and detects surface element and also locks in the relevant position.This can utilize comprise can be in the second level equipment of further compressive state lock adjustment appliance arrangement finish.
In another embodiment of the invention, place movable member in the container when the vessel port direction promotes, airtight container tightly, thus the tip can remove.
According to preferred embodiment, regulating device can be removed, so the experimenter can touch the movable member that places in the container, for example can further check or monitor testing result.
According to another preferred embodiment, vessel port can be by an independently obturator sealing, and remaining liquid can be from the opening part flow container when taking the movable member that places in the container away in the container like this.This obturator can be at container outside or inner.The closing motion of obturator is preferably finished by moving of movable member, for example by placing the mechanical motion of the first of movable member in the container.When using independently inner obturator, especially preferred said process.As top mentioned, in a kind of embodiment in back, placing the movable member in the container must be mechanical effect at least, and this evacuation section can be conditioned the device promotion when regulating device is compressed to the further compressive state in the second level, and preferably, when further compressing, first order compressive state is pushed in regulating device.Therefore, more preferably be formed on independently obturator of inside, thus the mechanical motion of movable member first that can be by placing internal tank and closed container.
In a further preferred embodiment, the removable regulating device movable member interior with placing container can be locked to each other, like this as long as just can remove movable member by removing regulating device.In this embodiment, the removable regulating device movable member interior with placing container illustrated the device that locks described regulating device and movable member.By mechanical caging, the locking as friction just can form.When erecting equipment, just can finish locking, and, for mechanical caging, when operating equipment, also can realize.
Terminology used here detects the surface, is defined as the total detection surface on the movable member that places in the container.
Brief Description Of Drawings
Figure 1 shows that the front view and the side view of embodiment of the present invention.
Figure 2 shows that the embodiment identical with Fig. 1, soft and regulating device that can rebound is in first order compressive state in Fig. 2, can suck liquid.
Fig. 3 has described the embodiment identical with Fig. 1 and Fig. 2, and regulating device is in the further compressive state in the second level among the figure, has removed long tip.
Figure 4 shows that three different visual angles figure of one embodiment of this invention outside.
Figure 5 shows that according to the separate internal obturator in the described equipment container of an embodiment.
Fig. 6 has showed the device with movable member and the mutual locking of regulating device.
The present invention describes in detail
Describe the present invention hereinafter with reference to embodiment shown in the accompanying drawing.
The equipment 10 that accompanying drawing shows comprises detachable most advanced and sophisticated 20 of the length with first opening 21 and second opening 22, container 30 with transparent part and opening 31, this opening 31 can link to each other with an opening at tip at least, soft and can rebound folding dome-shaped regulating device 40, but the air when acting mechanically on regulating device outside in the emptying receptacles, described regulating device links to each other with container, has a movable member 50 that detects surface 51, this movable member places in the container, can examine from container appearances by the transparent part of container and detect the surface.
According to the present invention, moving of movable member 50 finished by the mechanical effect of regulating device 40, can be driven as this regulating device to contact with the second portion 53 of movable member.Therefore, for promoting movable member, this contact is in the further compressive state in the second level in regulating device at least, and preferably sets up when first order compressive state is further compressed in regulating device.Embodiment has obviously satisfied this requirement, and in this embodiment, as pre-established this contact in the installation of equipment or in making, in this case in case compress described regulating device, described second portion 53 just can be by this regulating device machinery promotion.
The operation of this equipment is very directly simple.
For with the equipment filled with fluid, as shown in Figure 1, earlier unpressed softness and the regulating device 40 that can rebound are compressed to first order compressive state, then second opening 22 and most advanced and sophisticated 20 is immersed liquid to be studied, this moment, regulating device as shown in Figure 2, still remained on first order compressive state.Relieving is applied to the external pressure of regulating device, and regulating device returns to original uncompressed state as shown in Figure 1, and liquid is just by the most advanced and sophisticated detection surface 51 that flows into container 30 and wetting movable member 50.
Fully wetting or when contacting fully when described detection surface with liquid, regulating device is applied external pressure extrude liquid in the container, thereby compress described regulating device to first order compressive state, as shown in Figure 2.To the further compressive state in the second level, as shown in Figure 3, regulating device acts mechanically on movable member 50 and makes 50 to move to opening 31 directions by further compression adjustment device 40.
When compression adjustment device and mobile movable member 50, the first 52 of movable member 50 inserts the opening 31. of container when first's 52 insertion openings 31, and the removable tip that is inserted in this opening is dismantled with regard to being moved.Apply the edge that acts mechanically on most advanced and sophisticated first opening 21 and help first 52 discharge tips.Therefore the tip removes from container.As shown in Figure 3, if research contains the liquid of microorganism, remove most advanced and sophisticated equipment and can directly cultivate in this state.
Regulating device 40 has illustrated in the second level the further method of compression place lock adjustment device 40.By the self-locking action that for example elasticity thing is oppositely placed, the reverse placement as collapsible dome can realize these methods, as shown in FIG..The method of locking is less demanding and any as long as do not hinder the method for regulating device effect all feasible.
Regulating device 40 is preferably detachable.Like this, can be conveniently near the built-in member of container, for example for more detailed inspection or evaluation testing result.Therefore, under the situation of circular open 32, and described device 40 should be circumference mutually, can make suitable screw thread at described device 40 edges.Obviously, other forms of cooperation also can make regulating device detachable, as numerous frictional fit, such as, regulating device is locked in hasp on the container.
In preferred embodiments, when regulating device contacted with movable member second portion 53, regulating device 40 and movable member 50 had been set up the coupling arrangement 70 and 71 of mechanical connection.This embodiment as shown in Figure 6.In the embodiments shown, mechanical connection can pass through friction lock, as spherical hasp in the drawings.In the embodiment depicted in fig. 6, coupling arrangement locks when operation of equipment.The type that connects according to the present invention is less demanding.Preferred firm as far as possible connection when extracting movable member from container, has limited movable member and has moved with respect to any unwanted of regulating device like this.But, for understanding used locking device easily and must allow two parts 70 and 71 to rotate each other, as shown in Figure 6 embodiment by the regulating device that detachable screw thread is arranged 40 of rotation dismounting.
It must be understood that simultaneously when production or erecting equipment and just can finish connection.The function of mechanical connection remains identical, and unique difference is to be connected in advance because of regulating device 40 with movable member second portion 53, and no matter regulating device is compressive state or keeps its initial uncompressed state, and movable member all will be moved.Coupling arrangement is less demanding, and suitable coupling arrangement is clearly for reading those skilled in the art that the present invention describes, and for example can be bar-like portion 70, and this bar-like portion extends to respective aperture 71 on the movable member second portion from regulating device.Although do not allow rotation, but still keep mechanical connection firm, and make that regulating device and the integral body that places inner movable member to form are believable.
Long tip 20 embeds the opening of container and forms detachable locking by friction at this opening part of container.Therefore, being applied to the most advanced and sophisticated pressure of regulating device place release at least should be suitable with the friction force that most advanced and sophisticated head is fixed on the vessel port embedded location.Friction lock is less demanding and can set up by usual manner known in the art.Required friction for example can be only wringing fit by the most advanced and sophisticated upper end circumference that embeds opening 31 realize that as shown in drawings, or by most advanced and sophisticated snap fit (not having diagram) in vessel port, or any other suitable manner realizes.
Clearly, the tip must be enough airtight to empty G﹠W with being connected of container, so that can form required high or low pressure by regulating device 40 effects in container.Otherwise the function of equipment will be endangered and may be run into leakage problem when operating equipment.Therefore, have in the embodiment at the detachable tip on the equipment of being connected in the present invention, the tip must closely be connected with the opening 31 of container 30.
The geometric configuration of the first 52 of movable member 50 is unimportant, but preferable shape is such as allowing this first can embed opening 31, or can extrude at least most advanced and sophisticated 20, as extruding the tip by applying the part edge that mechanical force acts on first opening 21 at least.
Perhaps, as shown in Figure 3, first 52 should become definite shape so that when introducing opening 31, can tight seal opening 31.Certainly, for sealed open 31, first 52 should have the geometric configuration that is fit to form with opening 31 corresponding fluid-tight engagement on its circumference, can move the tip 20 of embedding simultaneously.Obviously, this can be realized and be not the key of function of the present invention by a lot of modes.For example, for the tubular opening 31 of circular cross sections, first's 52 preferred respective shapes that are fit to this opening.The length of described first can only be that extrude from opening at the tip that will embed 20, and does not preferably reach the required length in outside of this opening.
In another alternative embodiment, provide independently inner obturator 60 in the container.In embodiment shown in Figure 5, described device 60 uses with the opening 61 that allows liquid turnover container.When regulating device enters the further compressive state in the second level and movable member 50 when therefore mobile, obturator 60 is in opening 61 sealings and does not have the liquid can be by the position of this opening.With reference to Fig. 5, this inner obturator 60 has been described, its split shed 61 is moved to this close circumference area that device is higher.Any remaining liq is revealed by opening 31 in the taking-up of this obturator built-in movable member after allowing to detect and the prevention container.Like this, prevent remaining liquid contamination surrounding environment in any container.
In another alternative embodiment, used outside obturator 60.This outside obturator is mainly used in obturator, and regular meeting cooperates with opening 31.For example this obturator can be taked suitable shape so that the one end cooperates with opening 22, and the other end cooperates with opening 31.
Soft and regulating device 40 that can rebound is exhaust (gas displacing) member, and can be made up of the dome of elastic foldable as shown in drawings.As long as regulating device 40 can effectively raise or reduce pressure in the container, the shape of regulating device 40 is not crucial.Obviously, the shape of this exhaust component must closely be connected to container, so that regulating device 40 can be fulfiled its specific function.Though accompanying drawing is to be appreciated that to place the collapsible dome explanation of opening 32 inside this dome also can place the outside of opening 32.Equally, this dome can be replaced by other any suitable exhaust apparatus, and as corrugated tube shape (bellow-like) device, this device must contact so that it is moved with movable member equally.
The shape of the shape of equipment, especially container is not very important.But the geometric configuration of preferred container conforms to substantially with built-in movable member, because in this case, fills up the necessary liquid volume of container and will reduce to minimum.Be the space of container,, should preferably mainly occupy by movable member 50 except 33 parts that link to each other with regulating device.
Embodiment shown in the accompanying drawing is a preferred embodiment, therein, container shapes is also considered big overall detection surface when the ergonomics geometric configuration of an equipment is provided, with the less liquid volume of filling up container, but so that only use just this equipment of simple operations of a hand.
The preferred inertia of container, transparent, or trnaslucent materials manufacturing are as glass or plastics.Can the chemical property of contact liq be selected the employed suitable material of container according to equipment.
The thermoplastics compatible with biological solution is preferred, and this is because this kind equipment is expected at extensive practicality is arranged on the biological solution.The example of these materials has polystyrene, polycarbonate and polyolefin, as polypropylene and tygon.The material that is used for making container part should all be inertia to the reagent of any use.Term inert used herein refers to the material that exists in the solvent that uses and reagent and the sample, the material in biological sample such as body fluid especially, and to different pH environment, especially the environment that runs in biochemical liquid lacks chemical reactivity.These materials also should be able to be cultivated in the detection of movable member microorganism lip-deep to be studied when movable member is still in container.
Regulating device 40 can be made by the material of any characteristic of considering the prerequisite softness of regulating device and can rebounding, and and the function of obstruction equipment within reason.Therefore, these materials are inertia to any reagent and the liquid that uses preferably.Those skilled in the art understand employed suitable material on regulating device 40.
Term used herein is soft and can rebound, and purpose is a kind of regulating device of regulation, when this regulating device discharges from first order compressive state, as shown in Figure 2, can return to uncompressed state; As shown in Figure 1.
Understand as this area, as WO9842821, any detection surface 51 in the container on the movable member 50 can be subdivided into many different surfaces, as scribbles one deck agar, or any other reagent is provided, as microbiotic.Whether no matter different detection surfaces segmented, and any suitable geometric configuration can be arranged and is not very crucial to the present invention.Whether no matter different detection surfaces segmented, and different functions can be provided, the different qualities relevant, or the different test experience of carrying out as the need tracer liquid, as treat the detection of the analyte of certain research in the tracer liquid.These test experience can be carried out simultaneously or be carried out as selectivity experiment, by employed specified conditions decision.Therefore, can provide any suitable chemical reactor and indicator, probe, oligonucleotides, growth medium etc. on the detection surface.
Obviously, detect the shape decision of surperficial number and shape by built-in movable member 50.As can being rectangular cross section from visible this movable member of accompanying drawing, in this case, two big surfaces are particularly suitable as detects the surface, or triangular cross section, in this case, angle on triangular cross section is decided, and may obtain being suitable as three surfaces detecting the surface.Also can use the movable member 50 of any other suitable shape, as have the geometric configuration of circle or oval cross section.
One of movable member 50 is detected the surface and also can form one or more concave surfaces (basin).This concave surface can be used for relatively thicker detection layers, and agar plate for example is as thicker relatively agar cast panel, as the 2-5 millimeters thick.
Most advanced and sophisticated 20 can make with any suitable material, as long as the functions of use that influences equipment within reason.Therefore, these materials are inertia to any reagent and the liquid that uses preferably, and can be metal, glass or plastics.The selection of decision material can be based on economic angle, and for example, more durable material should be used in the tip that can be recycled if desired, and this material can be resisted any suitable repeated washing operation, as radiation or chemical reagent, autoclave etc.For disposable tip, should use the material that can provide cost efficiency and simple process.Usually preferred plastic material.
Usually, in the inside at tip filtrator (not shown) can be arranged.This filtrator is any conventional filtration device of knowing in this area, and if necessary, also can contain the reagent that need be added in the liquid sample.Be arranged in most advanced and sophisticated intraluminal filter substrate (matrix) and can filter out any particle that enters container meeting Interference Detection.Such filter substrate also allows to add easily desired material, and these materials join in the filtrator in advance, flows through filtrator during to container when fluid sample, and material just can add, or the combination of these functions.The suitable material that joins in the filtrator can be that any needs join the material in the liquid sample, as reagent or detect the tracer agent, complexing agent, sequestrant, colorant etc. of specific analyte in surfactant, indicator, the liquid sample.
Movable member 50 has surfacewise wheel rim (rim) or the part that 51 edge raises when needed, or segment the screw thread (ridge) of the rising on described surface, these parts raise from the detection faces of movable member 50, are used to prevent detect the surface and contact (not shown) with internal tank and/or reduce the amount of friction that runs into when movable member moves.
Although only describe the microorganism that is used for tracer liquid, be to be appreciated that this equipment also can be used for the detection of any other material, for example owing to β ray or toxicity, it is harmful to make that these materials contact with application on human skin, need be limited in the container.
Claims (13)
1. the sampling and the equipment of tracer liquid comprise:
A) most advanced and sophisticated (20), it has first and second openings (21,22),
B) have the container (30) of an opening (31), this opening can link to each other with first opening (21) at tip,
C) in the described container of emptying air and move the regulating device (40) that places the movable member (50) in the container and
D) place the movable member (50) of described container, it comprises the first (52) that points to opening (31), second portion (53) and detect surperficial (51),
Wherein said regulating device is for soft and can rebound, and links to each other with described container, and described regulating device and described container have formed the continuous compartment with opening (31), and described regulating device acts mechanically on described second section (53).
2. according to the equipment of claim 1, wherein regulating device (40) is compressible on the direction of pointing to second portion (53).
3. according to the equipment of claim 1 or 2, wherein most advanced and sophisticated head (20) is dismountable.
4. according to the equipment of any front claim, wherein first (52) is movable to opening (31).
5. according to the equipment of any front claim, wherein first (52) has and opening (31) the shape geometric configuration of mapping mutually, can effectively seal this opening.
6. according to the equipment of any front claim, be included in the device of the second level further compressive state lock adjustment device (40).
7. according to the equipment of any front claim, wherein regulating device (40) comprises a collapsible elasticity dome.
8. according to the equipment of any front claim, wherein provide the tip that filtrator is arranged (20).
9. according to the equipment of any front claim, wherein regulating device is dismountable.
10. according to the equipment of any front claim, comprise independent closed device (60).
11. according to the equipment of any front claim, regulating device (40) and place movable member (50) in the container to have and place movable member device connected to one another (70,71) in the container wherein with described regulating device.
12. the detection of simplifying and the method for analysing fluid sample comprise the following steps:
A) provide the sampling and the equipment of tracer liquid, comprising:
A) tip (20), it has first and second openings (21,22); B) have the container (30) of an opening (31), this opening (31) can link to each other with first opening (21) at tip; C) link to each other with described container soft and the regulating device (40) that can rebound are used in the described container of emptying movable member (50) in the air and mobile containers, described regulating device and container formed continuous compartment with opening (31) and; D) place the movable member (50) of described container, comprise the first (52) that points to opening (31), second section (53) of described regulating device mechanical effect and detect surperficial (51),
B) make regulating device (40) be in first order compressive state,
C) discharge regulating device (40) from first order compressive state, thereby make described movable member keep its original not compressed format.
13., further comprise the steps: according to claim 12 method
D) make regulating device (40) be compressed to the further compressive state in the second level, thereby promote to place the movable member (50) in the container.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011370017A CN1313592C (en) | 2001-10-18 | 2001-10-18 | Equipment and method for detecting liquid fluid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011370017A CN1313592C (en) | 2001-10-18 | 2001-10-18 | Equipment and method for detecting liquid fluid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1412559A true CN1412559A (en) | 2003-04-23 |
| CN1313592C CN1313592C (en) | 2007-05-02 |
Family
ID=4674072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011370017A Expired - Fee Related CN1313592C (en) | 2001-10-18 | 2001-10-18 | Equipment and method for detecting liquid fluid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1313592C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106796216A (en) * | 2014-10-16 | 2017-05-31 | 通用电气医疗集团英国有限公司 | For a point cellifugal apparatus and method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0356150A (en) * | 1989-05-18 | 1991-03-11 | Monoclonal Antibodies Inc | Use of filter type applicator and filter type applicator; method for detecting using analyzing device used therewith and sample-transferring method; assembly set for immunoassay |
| SE9500682L (en) * | 1995-02-24 | 1996-04-15 | Stig Staalhandske | Device for testing the resistance of bacteria present in urine |
-
2001
- 2001-10-18 CN CNB011370017A patent/CN1313592C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106796216A (en) * | 2014-10-16 | 2017-05-31 | 通用电气医疗集团英国有限公司 | For a point cellifugal apparatus and method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1313592C (en) | 2007-05-02 |
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