CN1408385A - Medicine for curing summer heat wetness cold and preparing method - Google Patents
Medicine for curing summer heat wetness cold and preparing method Download PDFInfo
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- CN1408385A CN1408385A CN 01128220 CN01128220A CN1408385A CN 1408385 A CN1408385 A CN 1408385A CN 01128220 CN01128220 CN 01128220 CN 01128220 A CN01128220 A CN 01128220A CN 1408385 A CN1408385 A CN 1408385A
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- volatile oil
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Abstract
The medicine for curing summer heat wetness cold is the mixture of the volatile oil and water extractive of cabling patchouli, perilla stem, herb of fortune eupatorium and aomum fruit. The preparation process includes water extraction of volatile oil, beta-CD coating, low temperature drying, crushing, filtering the water extractive, concentration, alcohol extraction, regulating pH filtrate adsorption in macroporous resin, concentration, adding dextrin, drying, crushing, mixing extractive powder and coated volatile oil and packing. The medicine can treat summer heat wetness cold effectively.
Description
Technical field:
The present invention relates to a kind of medicine concrete be to be the Chinese patent medicine and preparation method thereof of the treatment summer-heat damp cold of feedstock production with the Chinese herbal medicine.
Background technology:
The summer-heat damp cold traditional Chinese medical science thinks that summer-heat often mixed with damp hurts sb.'s feelings, and is burnt in the retardance, or the internal injury heat-damp in summer, external beam wind and cold.And reveal any symptoms is heating, diarrhoea, stomachache, nausea and vomiting.This disease belongs to commonly encountered diseases, frequently-occurring disease in spring and summer, doctor trained in Western medicine just adopts conventional common cold treatment means, most DeGrains to this sick no specific Therapeutic Method.The traditional Chinese medical science adopts dispelling summer-heat from superficies of the body then according to its pathogeny, and Therapeutic Principle's curative effect of the dampness removing that drives away summer heat is more obvious, and representing prescription is HUOXIANG ZHENGQI WAN or HUOXIANG ZHENGQI SHUI.The problem that these medicines exist at first is that prescription is formed complexity, and next dosage form is taken and carry convenient inadequately, or is difficult for preserving.
The objective of the invention is under the prerequisite that keeps curative effect, provide a kind of composition simple, improve a kind of medicine and preparation method for the treatment of summer-heat damp cold of dosage form, to overcome the prior art above shortcomings.
Summary of the invention:
Medicine of the present invention is Herba Pogostemonis, Caulis Perillae, Herba Eupatorii, the Radix Aucklandiae, the volatile oil of Fructus Amomi and the mixture of water extract of equal portions.
The preparation method of medicine of the present invention is:
A, water extract volatile oil, the institute's volatile oil of proposing β-CDBao He, clathrate cold drying, pulverizing in the Herba Pogostemonis of equal portions, Caulis Perillae, Herba Eupatorii, the Radix Aucklandiae, Fructus Amomi;
B, the water extract that will isolate volatile oil filter, concentrate, add the ethanol alcohol extraction, and the accent pH value is strong basicity, and is static, filter, and transferring pH value again is weak acid, and be static, filter D
101The macroporous resin column separating effective ingredient is condensed into silk fabric cream, adds the dextrin of 2 times of amounts, mixes thoroughly, and drying under reduced pressure is pulverized;
C, with the volatile oil mixing packing behind water extract extract powder and the enclose.
Good effect of the present invention is: the present invention is according to the Therapeutic Principle of theory of Chinese medical science to summer-heat damp cold, in conjunction with the modern pharmacology experimental technique, prove that fully this medicine 400-100mg/Kg has analgesia, enterokinesia is told, suppressed in the town, alleviate the intestinal tube spasm, so can treat stomachache and the diarrhoea that enterospasm causes; This medicine can prolong the time-to-live of animal under hot conditions simultaneously, and it is unbalance to alleviate the electrolyte metabolism that too much occurs owing to sweating, can have antibacterial and certain refrigeration function.This medicine preparation technology advanced person adopts macroporous adsorptive resins in addition, and effective ingredient is made with extra care in the side of making, and also makes the quality standard of preparation be easier to control simultaneously; Volatile oil adopts β-CDBao He in the extract, is easier to long preservation, is unlikely to the effective ingredient volatilization; Adopt capsule, volume is little, is more convenient for taking and carrying.Therefore, can be used as health care and the medicine that prevents summer-heat damp cold summer.
To the influence of mice carbon powder ahead running (X ± s)
Group number of animals fltting speed
(only)
Blank group 11 0.66 ± 0.115
HUOXIANG ZHENGQI WAN 15.4Kg 11 0.60 ± 0.137
Clearing away summer-heat capsule 400mg/Kg 11 0.50 ± 0.076
* *
200mg/Kg 11 0.63±0.103
100mg/Kg 11 0.57 ± 0.132 Dichlorodiphenyl Acetate causes the influence (X ± s) of mouse writhing reaction
The group number of animals is turned round the body number of times
(only)
Blank group 12 26.8 ± 8.26
HUOXIANG ZHENGQI WAN 15.4g/Kg 12 11.2 ± 9.40
* *
Clearing away summer-heat capsule 400mg/Kg 12 7.1 ± 5.20
* *
200mg/Kg 12 7.1±8.49
***
100mg/Kg 12 8.0 ± 5.63
* *To the influence of normal diarrhea of mouse (X ± s)
The group number of animals loose stool of always just counting is counted
(only)
Blank group 13 22.2 ± 3.85 4.54 ± 1.266
HUOXIANG ZHENGQI WAN 15.4g/Kg 13 13.9 ± 1.50
* *3.54 ± 1.450
Clearing away summer-heat capsule 400mg/Kg 13 22.2 ± 5.51 3.08 ± 0.641
* *
200mg/Kg 13 17.2±3.03
**?3.54±1810
100mg/Kg 13 18.8±4.00
* 4.08±1.256
Annotate: with blank group ratio
*P＜0.05,
*P＜0.01,
* *P＜0.001 (above each table all with)
The preferred embodiments of the present invention are: with Herba Pogostemonis, Caulis Perillae, Herba Eupatorii, the Radix Aucklandiae, Fructus Amomi five kinds of Chinese medicine is raw material, the amount of getting is 1: 1: 1 by ratio of weight and the number of copies: 1: 1, after the cleaning, get Fructus Amomi earlier, put in the volatile oil extractor, add 8 times of water, extract volatile oil, extraction time is 20 hours, and volatile oil deposits in addition in the container and preserves, the water extract filters, and is standby.Residue four flavors are put in the volatile oil extractor, add 8 times of water, extract volatile oil, and extraction time is 8 hours, and the volatile oil of this kind volatile oil and said extracted merges.The water extract filters, and adds in the above-mentioned water extract, and being concentrated into relative density is 1.05-1.15 (60 ℃), adds ethanol, make that to contain alcohol amount be 60%, left standstill 24 hours, filter filtrate recycling ethanol, continuing to be concentrated into relative density is 1.15-1.20 (60 ℃), adds ethanol, makes to contain the alcohol amount and reach 80%, leaves standstill 24 hours, filter, filtrate recycling ethanol concentrates, adding calcium hydroxide is transferred PH to 11, leaves standstill, and filters, it is 6 that filtrate is transferred pH value with dilute hydrochloric acid, filters, and filtrate is passed through D
101Macroporous resin column, first water is eluted to the color reaction of sugar-free, and reuse 70% ethanol 3000ml eluting is collected eluent, is condensed into silk fabric cream, adds the dextrin of 2 times of amounts, mixes thoroughly, and drying under reduced pressure is crushed to 40-60 purpose fine powder, and preferably 60 orders are standby.The volatile oil of carrying with the β-CDBao He of 1: 5 times (weight ratio), the enclose temperature is 30 ℃, clathrate places cold drying (being no more than 45 ℃) in the baking oven, pulverizes, and with above-mentioned medicated powder mixing, incapsulates, and promptly gets medicine of the present invention.
Claims (2)
1, a kind of medicine for the treatment of summer-heat damp cold is characterized in that this medicine is Herba Pogostemonis, Caulis Perillae, Herba Eupatorii, the Radix Aucklandiae, the volatile oil of Fructus Amomi and the mixture of water extract of equal portions.
2, a kind of preparation method for the treatment of the medicine of summer-heat damp cold is characterized in that:
A, water extract volatile oil, the institute's volatile oil of proposing β-CDBao He, clathrate cold drying, pulverizing in the Herba Pogostemonis of equal portions, Caulis Perillae, Herba Eupatorii, the Radix Aucklandiae, Fructus Amomi;
B, will isolate volatile oil water filtration, concentrate, add the ethanol alcohol extraction, transferring pH value is that strong basicity is static, filters, transferring pH value again is weak acid, static, filter D
101The macroporous resin column separating effective ingredient is condensed into silk fabric cream, adds the dextrin of 2 times of amounts, mixes thoroughly, and drying under reduced pressure is pulverized;
C, with volatile oil mixing packing behind water extract extract powder and the enclose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01128220 CN1253192C (en) | 2001-09-27 | 2001-09-27 | Medicine for curing summer heat wetness cold and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01128220 CN1253192C (en) | 2001-09-27 | 2001-09-27 | Medicine for curing summer heat wetness cold and preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1408385A true CN1408385A (en) | 2003-04-09 |
| CN1253192C CN1253192C (en) | 2006-04-26 |
Family
ID=4668102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01128220 Expired - Fee Related CN1253192C (en) | 2001-09-27 | 2001-09-27 | Medicine for curing summer heat wetness cold and preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1253192C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869675A (en) * | 2010-05-25 | 2010-10-27 | 广东台城制药股份有限公司 | Chinese medicinal composition granules for treating summer-heat damp cold and preparation method thereof |
| CN106072598A (en) * | 2016-07-27 | 2016-11-09 | 东莞华创客驿食品技术开发有限公司 | Have suppression maiden's property implication function makes Fengshun water composition and the manufacture method of Fengshun water |
| CN106173888A (en) * | 2016-07-27 | 2016-12-07 | 东莞华创客驿食品技术开发有限公司 | There is making Fengshun water composition and the manufacture method of Fengshun water suppressing senile implication function |
| CN106173887A (en) * | 2016-07-27 | 2016-12-07 | 东莞华创客驿食品技术开发有限公司 | Have suppression work and rest irregularity implication function makes Fengshun water composition and the manufacture method of Fengshun water |
| CN106213145A (en) * | 2016-07-27 | 2016-12-14 | 东莞华创客驿食品技术开发有限公司 | Have suppression mouth source property implication function makes Fengshun water composition and the manufacture method of Fengshun water |
| CN106213147A (en) * | 2016-07-26 | 2016-12-14 | 东莞华创客驿食品技术开发有限公司 | Have suppression implication function makes Fengshun water composition and the manufacture method of Fengshun water |
-
2001
- 2001-09-27 CN CN 01128220 patent/CN1253192C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869675A (en) * | 2010-05-25 | 2010-10-27 | 广东台城制药股份有限公司 | Chinese medicinal composition granules for treating summer-heat damp cold and preparation method thereof |
| CN101869675B (en) * | 2010-05-25 | 2011-06-29 | 广东台城制药股份有限公司 | Chinese medicinal composition granules for treating summer-heat damp cold and preparation method thereof |
| CN106213147A (en) * | 2016-07-26 | 2016-12-14 | 东莞华创客驿食品技术开发有限公司 | Have suppression implication function makes Fengshun water composition and the manufacture method of Fengshun water |
| CN106072598A (en) * | 2016-07-27 | 2016-11-09 | 东莞华创客驿食品技术开发有限公司 | Have suppression maiden's property implication function makes Fengshun water composition and the manufacture method of Fengshun water |
| CN106173888A (en) * | 2016-07-27 | 2016-12-07 | 东莞华创客驿食品技术开发有限公司 | There is making Fengshun water composition and the manufacture method of Fengshun water suppressing senile implication function |
| CN106173887A (en) * | 2016-07-27 | 2016-12-07 | 东莞华创客驿食品技术开发有限公司 | Have suppression work and rest irregularity implication function makes Fengshun water composition and the manufacture method of Fengshun water |
| CN106213145A (en) * | 2016-07-27 | 2016-12-14 | 东莞华创客驿食品技术开发有限公司 | Have suppression mouth source property implication function makes Fengshun water composition and the manufacture method of Fengshun water |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1253192C (en) | 2006-04-26 |
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Owner name: ZENG QINGZHONG HUANG WENXIU XU HUIBO Free format text: FORMER OWNER: ZENG QINGZHONG CHEN XINZI HUANG WENXIU HUANG LIANG; YIN HUA Effective date: 20050311 |
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Effective date of registration: 20050311 Address after: 6 floor, 8 castle, Sha Tin, Hongkong Applicant after: Qian Zhongming Co-applicant after: Zeng Qingzhong Co-applicant after: Huang Wenxiu Co-applicant after: Xu Huibo Address before: 6 floor, 8 castle, Sha Tin, Hongkong Applicant before: Qian Zhongming Co-applicant before: Zeng Qingzhong Co-applicant before: Chen Xinzi Co-applicant before: Huang Wenxiu Co-applicant before: Huang Liang Co-applicant before: Yin Hua |
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