CN1403134A - Prepn of medicine for treating hepatosis - Google Patents
Prepn of medicine for treating hepatosis Download PDFInfo
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- CN1403134A CN1403134A CN 02133816 CN02133816A CN1403134A CN 1403134 A CN1403134 A CN 1403134A CN 02133816 CN02133816 CN 02133816 CN 02133816 A CN02133816 A CN 02133816A CN 1403134 A CN1403134 A CN 1403134A
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- penthorum chinense
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- pursh extract
- chinense pursh
- extract
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Abstract
The present invention relates to the preparation of medicine for treating hepatosis. Coarse Ganhuangcao powder is extracted with water or organic solvent to obtain extractive and the extractive is mixed with supplementary material to prepare the medicine in different forms, including tablet, capsule, dropping pill, injection, delayed releasing capsule, etc. The medicine is easy to take, high in biological utilization and long in the time for the active component of Ganhuangcao to act in the body.
Description
Technical field:
The present invention relates to a kind of preparation method for the treatment of the medicine of hepatopathy.
Technical background:
Penthorum chinense has another name called Herba Lysimachiae Clethroids, is the dry aerial parts of brave otology plant Herba Lysimachiae Clethroids Penthorum Chinese Pursh.Penthorum chinense is recorded in herbal for Relief of Famines the earliest, and the ancient medicine scholar thinks through research heat clearing away, effects such as detoxifcation, jaundice eliminating, removing dampness, be the various hepatitis of treatment among the people through proved recipe.The modern medicine experimentation finds that then Penthorum chinense has the effect of the various hepatitis of treatment, and energy jaundice eliminating subcutaneous ulcer, the liver protecting and ALT lowering are the various hepatitis courses of disease progress of control, eliminate the treating the liver good medicine of various clinical symptoms rapidly.
Traditional Penthorum chinense medicine is that dosage is big with the fried one-tenth water preparation of medical herbs, prepares and takes inconvenience, and bioavailability of medicament is low.
The content of invention:
The object of the present invention is to provide a kind of taking convenience, bioavailability height, the preparation method of the Penthorum chinense novel form that drug effect is long.
The present invention is achieved in that
The present invention treats the preparation method of the medicine of hepatopathy, the Penthorum chinense coarse powder adds water or solvent system extract, penthorum chinense pursh extract is added adjuvant make capsule or enteric coated capsule or slow releasing capsule or Extencap or soft capsule or oral liquid or dispersible tablet or enteric coatel tablets or slow releasing tablet or controlled release tablet or drop pill or injection.
The Penthorum chinense coarse powder is added 1-50 times of water gaging decoction 1-4 time, each 1-5 hour, collecting decoction, concentrated centrifugal, obtain supernatant, add ethanol or methanol extraction, filter, concentrate, get penthorum chinense pursh extract.
The Penthorum chinense coarse powder is added 1-50 doubly measure methanol or alcohol reflux 1-4 time, each 1-5 hour, merge extractive liquid, concentrated centrifugally, obtains supernatant, and aqueous precipitation filters, concentrate, penthorum chinense pursh extract.
The Penthorum chinense coarse powder is added 1-50 times of water gaging decoct 1-4 time, each 1-5 hour, collecting decoction, concentrated centrifugal, obtain supernatant, add ethanol or methanol extraction, filter, concentrate, be dissolved in water, resin column on the aqueous solution, ethanol or methanol-eluted fractions obtain eluent, reclaim eluting solvent, drying, obtain penthorum chinense pursh extract.
The Penthorum chinense coarse powder is added 1-50 doubly measure methanol or alcohol reflux 1-4 time, each 1-5 hour, merge extractive liquid,, concentrated centrifugal, obtain supernatant, aqueous precipitation, filter, concentrate, be dissolved in water, adsorption resin column on the aqueous solution, ethanol or methanol-eluted fractions obtain eluent, reclaim eluting solvent, drying obtains penthorum chinense pursh extract.
The Penthorum chinense coarse powder is added 1-50 doubly measure organic solvent backflow 1-4 time, each 1-5 hour, merge extractive liquid, concentrated, and gets penthorum chinense pursh extract.
Penthorum chinense pursh extract is made tablet or dispersing tablet or sustained release tablets or controlled release tablet or capsule or capsulae enterosolubilis or enteric coatel tablets or spansule or controlled release capsule; Penthorum chinense pursh extract 1 weight portion; -------； Dry granulation or with 0.01-10% polyvinylpyrrolidone class or ethanol or starch slurry or distilled water or gelatine size wet granulation; Dry; Whole grain; Add again lubricant 0.01-10 weight portion dolomol or colloidality silica or superfine silica gel powder or polyvinylpyrrolidone class and mix rear compressing tablet or encapsulated or dress capsulae enterosolubilis or enteric coated, make tablet or dispersing tablet or sustained release tablets or controlled release tablet or capsule or capsulae enterosolubilis or enteric coatel tablets or spansule or controlled release capsule.
Penthorum chinense pursh extract is made soft capsule, penthorum chinense pursh extract with water or ethanol or vegetable oil or be solvent, is added emulsifying agent and makes suspension type Emulsion, adopt dropping preparation method or pressing to make soft capsule.
Penthorum chinense pursh extract is made oral liquid, sodium citrate or Polymeric sodium metaphosphate. or sodium glutamate and sodium citrate or glycerol or laminarin sulfate sodium or glucosides ester or sodium tripolyphosphate with 1 weight portion penthorum chinense pursh extract and 0.01-10 weight portion, 0.01-50 the hydroxy methocel of weight portion or hydroxypropyl emthylcellulose, 1-100 weight portion syrup mix homogeneously, add water to 1000 weight portions, packing gets the Penthorum chinense oral liquid.
Penthorum chinense pursh extract is made drop pill, with two or more 0.01-100 weight portion mix homogeneously in penthorum chinense pursh extract 1 weight portion and Polyethylene Glycol or propylene glycol or stearic acid or the above material, pack in drop bottle or the drop pill machine, in following system of 40-150 ℃ condition, splash in condensing agent ethanol or water or the liquid paraffin, take out after the molding, inhale with absorbent paper and remove adherent ethanol or water or liquid paraffin, intensive drying is made the Penthorum chinense drop pill.
Penthorum chinense pursh extract is made injection, penthorum chinense pursh extract is added 40-95% ethanol, stir 3-15min, filter, filtering residue reuse 50-95% ethanol dissolves once, refilters.Add an amount of distilled water in the filtrate, add 0.3-1.5% edible Gelatinum oxhide aqueous solution precipitation again, placed 3-12 hour, centrifugal, adsorb macroporous resin column on the supernatant, the reuse distilled water wash is collected effluent, vacuum drying.The mannitol of the refining penthorum chinense pursh extract of 1 weight portion and 0.001-100 weight portion or sorbitol or sodium chloride or benzyl alcohol or ethanol or tween 80 or glycerol or glucose are added injection water or oil for injection to 1000 weight portion, and packing promptly.
The present invention can improve the bioavailability of penthorum chinense pursh extract or prolong penthorum chinense pursh extract action time in vivo, reduces the number of times that patient takes medicine.
The specific embodiment:
The preparation method of penthorum chinense pursh extract
1, the Penthorum chinense coarse powder is decocted with water three times, each 2 hours, collecting decoction, concentrated centrifugal, obtain supernatant, with resin column on the supernatant, ethanol elution obtains ethanol elution, reclaims ethanol, and drying obtains penthorum chinense pursh extract.
2, the preparation method of penthorum chinense pursh extract tablet
The preparation of penthorum chinense pursh extract is with embodiment 1.
With 1000g penthorum chinense pursh extract and 1000g lactose mix homogeneously, add an amount of 10% starch slurry mix homogeneously, granulate, in 50-60 ℃ dry down, granulate adds 50g magnesium stearate mix homogeneously, after the assay was approved, tabletting.
3, the capsular preparation method of penthorum chinense pursh extract
The preparation of penthorum chinense pursh extract is with embodiment 1.
Prescription
Penthorum chinense pursh extract 250g starch 30g
Make 1000 altogether
Starch is carried out drying earlier, crosses 120 mesh sieves,, cross twice 120 mesh sieves then with the penthorum chinense pursh extract mix homogeneously, abundant mixing, inspect qualified after, divide in the capsulae vacuus of packing into, get the Penthorum chinense capsule.
4, penthorum chinense pursh extract preparation of soft capsule
The preparation of penthorum chinense pursh extract is with embodiment 1.
The preparation of gelatin solution: gelatin 100g, water 130g.Get an amount of water of gelatin adding and make its imbibition.In addition the water of glycerol and remainder is put and be heated to 70-80 ℃ in the glue pot, mix homogeneously adds expansible gelatin and stirs, and makes it to be melt into uniform glue, is incubated 1-2 hour and leaves standstill, and removes the foam of come-up, filters with cloth bag.Making gelatin viscosity is 2.8-3.2.
With penthorum chinense pursh extract is solvent with water, adds emulsifying agent and makes suspension type Emulsion.
With the gelatin glycerol that has made, put in the appropriate vessel and be incubated about 60 ℃, in addition the penthorum chinense pursh extract suspension is put into fuel tank, the temperature of liquid paraffin is advisable with 13-17 ℃, room temperature 10-20 ℃, drips (spray) head place and should be about 50 ℃.
The soft gelatin capsule that oozes is evenly spread out on gauze,, insert and remove surface liquid paraffin more than 4 hours in the blowing of low temperature below 10 ℃, took out in 20 hours 10 ℃ of low temperature blowings again, use ethanol: the mixed liquor flush away surface liquid paraffin of acetone=5: 1, again about 24 hours of 40-50 ℃ of drying.Drying, lamp inspection are used 95% washing with alcohol, dry up under 40-50 ℃, promptly again.
5, the preparation method of penthorum chinense pursh extract enteric coated capsule
The preparation of penthorum chinense pursh extract raw material is with embodiment 1.Prescription
Penthorum chinense pursh extract 250g lactose 30g
Make 1000 altogether
Lactose is carried out drying earlier, crosses 120 mesh sieves,, cross twice 120 mesh sieves then with the penthorum chinense pursh extract mix homogeneously, abundant mixing, inspect qualified after, divide in the empty enteric coated capsule of packing into, get the Penthorum chinense capsule.
6, penthorum chinense pursh extract slow (control) is released capsular preparation method
The preparation of penthorum chinense pursh extract raw material is with embodiment 1.
The preparation of penthorum chinense pursh extract ball core: get penthorum chinense pursh extract and the lactose fine powder is even with 1: 3 mixed, use 2% (g/ml) polyvinylpyrrolidone (K-30) pelletize then, (rotating speed is 23r/min by extruder, sieve aperture is 0.8-1.2mm) extrude, material (rotating speed is 950r/min) in spheronizator grinds and rolled 5 minutes, the wet ball of balling-up is in 50 ℃ of dryings 4 hours, promptly.
Coating:above-mentioned ball core is put in the coating pan; With prescription 1 and prescription 2 first coatings; Again on this coated pellets, wrap again respectively with write out a prescription 3 and prescription 4 promptly. coating solutions form prescription 1 prescription 2 ethyl cellulose 3.5g Eudragit RS100 5g diethyl phthalate 0.5g diethyl phthalate 0.5g mixed solvent 100ml mixed solvent 100ml prescription 3 prescription 4HPMCP 5.0g Eudragit R100 5g triacetyl glycerine 0.5g diethyl phthalate 0.5g mixed solvent 100ml mixed solvent 100ml
7, the preparation method of penthorum chinense pursh extract oral liquid
The preparation of penthorum chinense pursh extract is with embodiment 1.
With 500g penthorum chinense pursh extract crude drug and sodium citrate 7g, sodium carboxymethyl cellulose 15g and syrup 100g mix homogeneously, add water to 1000ml, promptly.
8, the preparation method of penthorum chinense pursh extract dispersible tablet
The preparation method of penthorum chinense pursh extract is with embodiment 1.
Low-substituted hydroxypropyl cellulose is crossed 80 mesh sieves, penthorum chinense pursh extract 125g, dimension swollen shallow lake P5000400g, polyvinylpolypyrrolidone INF-10 300g and PEG6000 250g and PEG4000 250g cross 100 mesh sieves, mix homogeneously, cross 80 mesh sieve secondaries, colloidality silicon dioxide, magnesium stearate are crossed 100 mesh sieves respectively, with above-mentioned mixed powder mix homogeneously, cross 80 mesh sieve secondary, direct powder compressions then.
9, the preparation method of penthorum chinense pursh extract enteric coatel tablets
The preparation method of penthorum chinense pursh extract is with embodiment 1.
With the lactose mix homogeneously of 5000g penthorum chinense pursh extract and 1000g, the starch slurry of adding 10%, to granulate, 50-60 ℃ of drying crossed 80 mesh sieve granulate, adds magnesium stearate lubricant 500g and polyvinylpyrrolidone 500g mix homogeneously again, tabletting.
Earlier label is screened out fine powder and broken mashed sheet, hang one deck sub-coat, wrap the zein sealing coat again 1-2 time, hang sub-coat number layer again, accomplish thin layer repeatedly, drying is evened up layer by layer.Hang cellulose acetate-phthalate (CAP) solution, behind the intermittent spraying drying and forming-film, detect, qualified after, continue to hang sub-coat again to stipulating that sheet is heavy, the icing layer, polishing, drying, the Penthorum chinense enteric coatel tablets.
10, penthorum chinense pursh extract slow (control) is released the preparation method of sheet
The preparation of penthorum chinense pursh extract is with embodiment 1.
With chitosan and sodium alginate mixed by 2: 3, add the mix homogeneously that sieves behind the medicine (mixture is 0.2: 1 with the ratio of medicine), with 30% ethanol water is wetting agent system soft material, cross 16 mesh sieve system wet granulars, 50-55 ℃ of dry back granulate adds tabletting behind the moderate lubrication agent magnesium stearate mixing.
11, the preparation method of penthorum chinense pursh extract drop pill
The preparation of penthorum chinense pursh extract is with embodiment 1.
Penthorum chinense pursh extract 1.5g
Polyethylene glycol 6000 6g
PEG400 0.6g
Propylene glycol 0.6g
Get exsiccant penthorum chinense pursh extract 1.5g and cross 100 mesh sieves, add Polyethylene Glycol 6000, PEG400 and propylene glycol, the heating in water bath fusion, pour in the drop pill machine after fully stirring and (be incubated 86 ℃ ± 1 ℃), constant temperature splashes in the refrigerative liquid paraffin, take out after the molding, inhale with absorbent paper and remove adherent liquid paraffin, make the Penthorum chinense drop pill.
12, the preparation method of penthorum chinense pursh extract injection
Penthorum chinense pursh extract is added 95% ethanol, stir 15min, filter, filtering residue reuse 95% ethanol dissolves once, refilters.Add an amount of distilled water in the filtrate, add 0.5% edible Gelatinum oxhide aqueous solution precipitation again, placed 12 hours, centrifugal, supernatant is crossed macroporous resin column, and the reuse distilled water wash is collected effluent, vacuum drying.With water for injection to 1000 weight portion, packing gets the penthorum chinense pursh extract injection with the sorbitol of the refining penthorum chinense pursh extract of 1 weight portion and 0.01 weight portion.
Claims (11)
1, a kind of preparation method for the treatment of the medicine of hepatopathy, it is characterized in that the Penthorum chinense coarse powder is added water or organic solvent system extract, penthorum chinense pursh extract is added adjuvant is made capsule or enteric coated capsule or slow (control) releases capsule or soft capsule or oral liquid or dispersible tablet or enteric coatel tablets or slow releasing tablet or controlled release tablet or drop pill or injection.
2, preparation method according to claim 1 is characterized in that the Penthorum chinense coarse powder is added 1-50 times of water gaging decoction 1-4 time, and each 1-5 hour, collecting decoction, concentrated centrifugal, obtain supernatant, add ethanol or methanol extraction, filter, concentrate, get penthorum chinense pursh extract.
3, preparation method according to claim 1 is characterized in that the Penthorum chinense coarse powder is added 1-50 doubly measures the organic solvent reflux, extract, 1-4 time, each 1-5 hour, and merge extractive liquid,, concentrated centrifugal, obtain supernatant, aqueous precipitation, filter, concentrate, get penthorum chinense pursh extract.
4, preparation method according to claim 1 is characterized in that the Penthorum chinense coarse powder is added 1-5 times of water gaging decocts each 1-5 hour 1-4 time, collecting decoction, concentrated centrifugal, obtain supernatant, add organic solvent deposition, filter, concentrate, be dissolved in water adsorption resin column on the aqueous solution, ethanol or methanol-eluted fractions, obtain eluent, reclaim eluting solvent, drying gets penthorum chinense pursh extract.
5, preparation method according to claim 1 is characterized in that the Penthorum chinense coarse powder is added 1-50 doubly measures the organic solvent reflux, extract, 1-4 time, each 1-5 hour, merge extractive liquid,, concentrated centrifugal, obtain supernatant, aqueous precipitation filters, and concentrates, be dissolved in water adsorption resin column on the aqueous solution, ethanol or methanol-eluted fractions, obtain eluent, reclaim eluting solvent, drying gets penthorum chinense pursh extract.
6, preparation method according to claim 1 is characterized in that the Penthorum chinense coarse powder is added 1-50 doubly measures organic solvent backflow 1-4 time, and each 1-5 hour, merge extractive liquid, concentrated, and gets penthorum chinense pursh extract.
7; Preparation method according to claim 1; It is characterized in that penthorum chinense pursh extract is made tablet or dispersing tablet or sustained release tablets or controlled release tablet or capsule or capsulae enterosolubilis or enteric coatel tablets or spansule or controlled release capsule; With penthorum chinense pursh extract 1 weight portion; -------； Dry granulation or with 0.01-10% polyvinylpyrrolidone class or ethanol or starch slurry or distilled water or gelatine size wet granulation; Dry; Whole grain; Add again lubricant 0.01-10 weight portion dolomol or colloidality silica or superfine silica gel powder or polyvinylpyrrolidone class and mix rear compressing tablet or encapsulated or dress capsulae enterosolubilis or enteric coated, make tablet or dispersing tablet or sustained release tablets or controlled release tablet or capsule or capsulae enterosolubilis or enteric coatel tablets or spansule or controlled release capsule.
8, preparation method according to claim 1 with water or ethanol or vegetable oil or be solvent, adds penthorum chinense pursh extract emulsifying agent and makes suspension type Emulsion, adopts dropping preparation method or pressing to make soft capsule suspension type Emulsion.
9, preparation method according to claim 1, it is characterized in that penthorum chinense pursh extract is made oral liquid, sodium citrate or Polymeric sodium metaphosphate. or sodium glutamate and sodium citrate or glycerol or laminarin sulfate sodium or glucosides ester or sodium tripolyphosphate with 1 weight portion penthorum chinense pursh extract and 0.01-10 weight portion, 0.01-50 the hydroxy methocel of weight portion or hydroxypropyl emthylcellulose, 0.01-100 weight portion syrup mix homogeneously, add water to 1000 weight portions, packing gets the Penthorum chinense oral liquid.
10, preparation method according to claim 1, it is characterized in that penthorum chinense pursh extract is made drop pill, with two or more 0.01-100 weight portion mix homogeneously in penthorum chinense pursh extract 1 weight portion and Polyethylene Glycol or propylene glycol or stearic acid or the above material, pack in drop bottle or the drop pill machine, in following system of 40-150 ℃ condition, splash in condensing agent ethanol or water or the liquid paraffin, take out after the molding, remove adherent ethanol or water or liquid paraffin with the absorbent paper suction, intensive drying is made the Penthorum chinense drop pill.
11, preparation method according to claim 1 is characterized in that penthorum chinense pursh extract is made injection, and penthorum chinense pursh extract is added 40-95% ethanol, stirs 3-15min, filters, and filtering residue reuse 50-95% ethanol dissolves once, refilters.Add an amount of distilled water in the filtrate, add 0.3-1.5% edible Gelatinum oxhide or sodium alginate aqueous solution precipitation again, placed 12 hours, centrifugal, supernatant is crossed macroporous resin column, and the reuse distilled water wash is collected effluent, vacuum drying.The mannitol of the refining penthorum chinense pursh extract of 1 weight portion and 0.001-100 weight portion or sorbitol or sodium chloride or benzyl alcohol or ethanol or tween 80 or glycerol or glucose are added injection water or oil for injection to 1000 weight portion, promptly get the Penthorum chinense injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021338167A CN1171623C (en) | 2002-09-27 | 2002-09-27 | Prepn of medicine for treating hepatosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021338167A CN1171623C (en) | 2002-09-27 | 2002-09-27 | Prepn of medicine for treating hepatosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1403134A true CN1403134A (en) | 2003-03-19 |
| CN1171623C CN1171623C (en) | 2004-10-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021338167A Expired - Fee Related CN1171623C (en) | 2002-09-27 | 2002-09-27 | Prepn of medicine for treating hepatosis |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100387263C (en) * | 2006-02-27 | 2008-05-14 | 成都科瑞德医药投资有限责任公司 | Medicinal composition for treating hepatopathy, and its preparing mehtod and use |
| CN102093459A (en) * | 2011-01-10 | 2011-06-15 | 中国人民解放军第二军医大学 | Penthorum chinense pursh extract and preparation method and application thereof |
| CN101721488B (en) * | 2009-12-08 | 2011-11-09 | 湖南省中药提取工程研究中心有限公司 | Pharmaceutical composition for treating liver diseases and prepration method thereof |
| CN102462701A (en) * | 2010-11-08 | 2012-05-23 | 中国中医科学院西苑医院 | Enzyme method for refining Chinese medicine extract |
| CN104840495A (en) * | 2015-06-17 | 2015-08-19 | 四川锦云堂中药饮片有限公司 | Process for extracting effective parts of penthorum chinense |
| CN104840494A (en) * | 2015-06-17 | 2015-08-19 | 四川锦云堂中药饮片有限公司 | Use of penthorum chinense pursh extract in preparing medicines for treating hepatitis c |
| CN105125601A (en) * | 2015-10-13 | 2015-12-09 | 四川古蔺肝苏药业有限公司 | Penthorum chinense pursh extract and preparing method and application thereof |
| CN106561899A (en) * | 2016-10-24 | 2017-04-19 | 湖北省农业科学院果树茶叶研究所 | Tea buccal tablet capable of protecting liver, and preparation method thereof |
| CN108904490A (en) * | 2018-06-28 | 2018-11-30 | 首都医科大学 | Application of the flavanone derivative in the drug for preparing anti-hepatic cell fattydegeneration in penthorum chinense pursh |
| CN109893551A (en) * | 2019-04-12 | 2019-06-18 | 云南金乌黑药制药有限公司 | A kind of production technology of liver Soviet Union dispersible tablet |
| CN110898088A (en) * | 2019-12-26 | 2020-03-24 | 成都锦华药业有限责任公司 | Preparation method of liver-protecting capsule |
| CN111467380A (en) * | 2020-05-13 | 2020-07-31 | 四川大学 | Penthorum chinense pursh extract microcapsule and preparation method thereof |
| CN111743155A (en) * | 2020-07-09 | 2020-10-09 | 武汉林宝莱生物科技有限公司 | Composite liver-protecting functional food and preparation method thereof |
-
2002
- 2002-09-27 CN CNB021338167A patent/CN1171623C/en not_active Expired - Fee Related
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100387263C (en) * | 2006-02-27 | 2008-05-14 | 成都科瑞德医药投资有限责任公司 | Medicinal composition for treating hepatopathy, and its preparing mehtod and use |
| CN101721488B (en) * | 2009-12-08 | 2011-11-09 | 湖南省中药提取工程研究中心有限公司 | Pharmaceutical composition for treating liver diseases and prepration method thereof |
| CN102462701B (en) * | 2010-11-08 | 2016-05-25 | 中国中医科学院西苑医院 | The method of enzyme process refining Chinese medicine extract |
| CN102462701A (en) * | 2010-11-08 | 2012-05-23 | 中国中医科学院西苑医院 | Enzyme method for refining Chinese medicine extract |
| CN102093459B (en) * | 2011-01-10 | 2012-10-17 | 中国人民解放军第二军医大学 | Penthorum chinense pursh extract and preparation method and application thereof |
| CN102093459A (en) * | 2011-01-10 | 2011-06-15 | 中国人民解放军第二军医大学 | Penthorum chinense pursh extract and preparation method and application thereof |
| CN104840495A (en) * | 2015-06-17 | 2015-08-19 | 四川锦云堂中药饮片有限公司 | Process for extracting effective parts of penthorum chinense |
| CN104840494A (en) * | 2015-06-17 | 2015-08-19 | 四川锦云堂中药饮片有限公司 | Use of penthorum chinense pursh extract in preparing medicines for treating hepatitis c |
| CN105125601A (en) * | 2015-10-13 | 2015-12-09 | 四川古蔺肝苏药业有限公司 | Penthorum chinense pursh extract and preparing method and application thereof |
| CN105125601B (en) * | 2015-10-13 | 2018-10-26 | 四川古蔺肝苏药业有限公司 | A kind of extract of penthorum chinense pursh and its preparation method and application |
| CN106561899A (en) * | 2016-10-24 | 2017-04-19 | 湖北省农业科学院果树茶叶研究所 | Tea buccal tablet capable of protecting liver, and preparation method thereof |
| CN108904490A (en) * | 2018-06-28 | 2018-11-30 | 首都医科大学 | Application of the flavanone derivative in the drug for preparing anti-hepatic cell fattydegeneration in penthorum chinense pursh |
| CN109893551A (en) * | 2019-04-12 | 2019-06-18 | 云南金乌黑药制药有限公司 | A kind of production technology of liver Soviet Union dispersible tablet |
| CN110898088A (en) * | 2019-12-26 | 2020-03-24 | 成都锦华药业有限责任公司 | Preparation method of liver-protecting capsule |
| CN111467380A (en) * | 2020-05-13 | 2020-07-31 | 四川大学 | Penthorum chinense pursh extract microcapsule and preparation method thereof |
| CN111743155A (en) * | 2020-07-09 | 2020-10-09 | 武汉林宝莱生物科技有限公司 | Composite liver-protecting functional food and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1171623C (en) | 2004-10-20 |
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