CN1395870A - Hypoglycemic health-care polypeptide food - Google Patents
Hypoglycemic health-care polypeptide food Download PDFInfo
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- CN1395870A CN1395870A CN02132671A CN02132671A CN1395870A CN 1395870 A CN1395870 A CN 1395870A CN 02132671 A CN02132671 A CN 02132671A CN 02132671 A CN02132671 A CN 02132671A CN 1395870 A CN1395870 A CN 1395870A
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- lactate
- rhizoma dioscoreae
- count
- zinc
- casein hydrolysate
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Abstract
A hypoglycemic health-care polypeptide food is prepared from compounding of hydrolytic casein, yam powder, calcium lactate, ferrous lactate and zinc lactate. Its advantage is high effect on reducing blood sugar, supplementing Ca, and preventing and treating hyperglycemia and diabetes.
Description
(1) technical field
The present invention relates to a kind of health food, particularly relate to a kind of function type health care food that is suitable for hyperglycemia people and diabetes patient.
(2) background technology
Diabetes---the traditional Chinese medical science claims " quenching one's thirst ", interior through claiming " diseases due to endogenous heat of ZANG FU organs ", is called different titles such as " diabetes involving the upper-JIAO ", " diabetes involving in upper-JIAO ", " in disappearing " according to the difference of pathogeny.Its etiology and pathogenesis mainly is: due to the factor affecting such as eating and drinking without temperance, disorder of emotion, impairment of the kidney due to indulgence in sexual activities, natural endowment deficiency or mistake clothes warm-dryness syndrome medicine, qi depression to blood stasis, YIN fluid deficiency, production of dryness-heat in the interior are the basic pathologies that primary disease takes place.Main clinical manifestation is " three-many-one-little ", promptly polydipsia, polyuria, polyphagia, become thin, and glucose in urine appears and blood glucose increases.Diabetes can be divided into constitutional and Secondary cases two classes.Secondary diabetes has caused the generation of diabetes mainly due to the reciprocal action between insulin resistant and the pancreatic beta cell functional defect; The cause of disease of primary diabetes mellitus and pathogeny are not clear fully as yet, the metabolism disorder that its basic pathology causes when being changed to the relative or absolute hyposecretion of insulin in the body.Though diabetes are not incurable diseases, modern medicine is thought obstinate disease, and touching difficulty more.Diabetes all can be fallen ill in the various ages, and more than the complication, it is anti-to allow people's air defense be unequal to, and the lighter tosses about in bed sickbed, weight person's threat to life.According to expert statistics, there is the people more than 200,000,000 to suffer from diabetes in the world.At present, China adult glycosuria prevalence is 3.2%, estimates that non-insulin-dependent diabetes mellitus (NIDDM) has more than 2000--3000 ten thousand people, is 2.7-3 times before 10 years.Along with Chinese economic development, the raising of living standards of the people, as effectively not controlled, this trend will further rise from now on, become the maximum country of diabetes number in the world.Existing both at home and abroad in, the preparation of diabetes treatment by western medicine only is maintenance therapy, although insulin can rescue some critical patients, because the further depletion of islet function that negative feedback inhibition caused makes the patient not have the day of rehabilitation forever.
(3) summary of the invention
The technical problem to be solved in the present invention provides a kind of help synthetic and excreting insulin, has obvious blood sugar reducing function, and can improve the hypoglycemic health-care polypeptide food of bone density.
The technical scheme that adopts is:
Hypoglycemic health-care polypeptide food, basically by casein hydrolysate, Rhizoma Dioscoreae powder, calcium lactate, ferrous lactate and zinc lactate are mixed with.To make the 100-400kg hypoglycemic health-care polypeptide food is example, and its charge ratio comprises: casein hydrolysate 15.6-82.4kg, Rhizoma Dioscoreae powder 15-60kg, calcium lactate are with Ca
+Count 12-56kg, ferrous lactate with Fe
+Count 0.2-0.8kg, zinc lactate with Zn
+Count 0.2-0.8kg.Mix through pressing compatibility, with the ethanol of 70-90% concentration, make soft material, cross (60-120 order) sieve series grain, vacuum drying promptly gets hypoglycemic health-care polypeptide food.
Above-mentioned zinc lactate can substitute with zinc gluconate, and with Zn
+Calculate inventory.
Above-mentioned casein hydrolysate is with enzyme engineering technology casein to be cut into pieces, and promptly is cut into polypeptide and aminoacid.Peptide one etymology is in Greek, i.e. " digestive " is the meaning of digestion, absorption.
Casein hydrolysate contains polypeptide, several amino acids and Ca, Fe, Zn etc., its preparation method is formulated by industrial casein or milk powder, calcium oxide, trypsin, its charge ratio is industrial casein (or milk powder) 80-150kg, calcium oxide 2.8-4.8kg, trypsin 2-6kg, add the 1000-1500kg distilled water, make through mixing, heat, stir, dust drying.
The production technology of casein hydrolysate, be with 80-150kg industry casein (or milk powder), put into jar fermenter, put into the 1000-1500kg distilled water again, heat temperature raising is to 35-45 ℃ while stirring, and adjusting PH is 4-5, adds calcium oxide 2.8-4.8kg then, be warming up to 60-78 ℃ gradually, after protecting special 20-30 minute, cool the temperature to 36-39 ℃ immediately, the cooling back adds trypsin 2-6kg, hydrolysis will be completely, the liquid gray, translucent body filters with centrifuge by colloid mill, again through deodorization, after the rust cleaning measure, squeeze in the spray tower with the homogenizing pump, at first adjust inlet temperature when dusting at 145-151 ℃, pressure is at 10-15Mpa, adjust temperature of outgoing air then at 70-75 ℃, pressure constantly detects water content simultaneously at 10-12Mpa, makes moisture content remain on 3-5%, to spray good powdery casein hydrolysate again, and remove bulky grain through vibrosieve and be finished product.
The end product quality standard:
(1) sense index:
Color and luster: milky or light yellow, homogenizing unanimity;
Taste: sweet, little hardship;
Purity: free from admixture exists.
(2) physical and chemical index:
Moisture content % :≤10;
Calcium content %: 〉=(1.0) (in Ca);
Iron content %:(is in Fe mg/kg) 100-500;
Total amino acid content (mg/kg) 〉=15000; 18 seed amino acids comprise alanine, arginine, aspartic acid, cystine, glutamic acid, lysine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, leucine, valine, isoleucine, glycine, histidine, methionine.
(3) microbiological indicator:
Total plate count: (individual/g)≤5000;
Coliform: (individual/100g)≤40;
Mycete: (individual/g)≤50;
Pathogenic bacterium: must not detect.
Casein hydrolysate, promptly polypeptide and aminoacid are for the essential raw material of human body synthetic protein and hormone, again can with the metallic ions Ca of two valencys
2+, Fe
2+, Zn
2+Forming complex, help absorption by human body and utilization, nutrient is not lost, is the carrier of mineral matter nutritional composition.Polypeptide promptly is the nutrient substance of supplying with to human body, has again to adjust and the physiological function of improving human body.
Ca
2+Scientific research now shows to have colourful biological function.Promote the growth promoter of human body, keep the irritability of N﹠M, excite the activity of body endoenzyme and the synthetic and secretion of hormone that important effect is all arranged.Diabetes patient and hyperglycemia population, the overwhelming majority is with osteoporosis, Ca
2+Can play the syndrome that the control hyperglycemia causes, physical strength reinforcing is eliminated osteodynia etc., makes it improve symptom and rehabilitation.
Fe
2+It is the nutrient that easily lacks, in the food particularly in the plant food utilization rate of ferrum very low, about 3-5%, often cause anemia because of iron deficiency, performance is easily irritated, cold and detached, resistance against diseases is low, easy catching a cold, pale complexion, dizziness, breathe hard, unable etc., additional ferrum can improve symptom, helps treatment of diabetes and prevention.
Zn
2+Being the trace element of needed by human, is the prothetic group of plurality of enzymes, RNA, the activatory indispensable element of archaeal dna polymerase.There is the interaction of many important physiological significances between zinc and hormone, the usefulness of hormone receptor and the reactivity of target organ are exerted an influence, also generation, storage and the secretion of hormone are worked, significantly reduce as the synthetic and secretion that lacks insulin zinc.At B
-In the cell, zinc and insulin form insoluble zinc-insulin complex by polymerization, store in the secretion body of gland, in the time of needs, discharge the biologically active insulin of single aggressiveness form again.Therefore, zinc deficiency or zinc in vivo the change of situation all can influence the vigor of synthetic, storage, secretion and the hormone thereof of insulin.
Zinc is to pancreatic function and glycometabolicly normally have certain influence, is the important biomolecule active substance of control of diabetes, indispensable nutrient.
The preparation method of above-mentioned Rhizoma Dioscoreae powder: get Rhizoma Dioscoreae and remove foreign body, washing is clean soaked after 2 hours, added the water of 2 times of amounts, decocted 30 minutes, filter, collect filtrate, the same operational approach of reuse 2 times repeatedly merges 3 extracting solution, vacuum concentration, to proportion 1.10, carry out spray drying again, promptly get extract.
The spray drying parameter:
Wet 160 ℃ of air intake, 80 ℃ of air-out humidities
Granularity 100-120 order
Proportion 1.08-1.10
Rhizoma Dioscoreae is the Dioscoreaceae plant, Rhizoma Dioscoreae Dioseoreo Oppositq Thund rhizome, and custom claims RHIIZOMA DIOSCOREAE frOm Henan of China.
The Rhizoma Dioscoreae composition includes:
1, Saponin
The Rhizoma Dioscoreae rhizome contains dioscin (dioacin) 2-4%, can get diosgenin (diosgenin) through acid hydrolysis, content about 0.1%.
2, protein
Protein content is 1.5%.Get glycoprotein (glycoproteine) in the Rhizoma Dioscoreae water extracting alcohol hypostasis, the glycoprotein hydrolysis gets 16 seed amino acids, i.e. lysine, histidine, arginine, aspartic acid, threonine, methionine, serine, glutamic acid, proline, alanine, glycine, valine, isoleucine, leucine, tyrosine, phenylalanine.
3, sugar
Polyoses content 2.15-2.92%, polysaccharide is made up of mannose, glucose and galactose, accounts for clear superiority with mannose.
4, starch
Starch accounts for 16%, still starch-containing enzyme.
5, phenolic constituent
Catecholamine (catecholamine), 3,4-dihydroxy benzenes ethamine (3,4-Dihydroxyphenylethylamine), dopamine (dopamine), hydrochloric acid Rhizoma Dioscoreae alkali (dastatasinehydrochorde), Rhizoma Dioscoreae plain I, II, III, IV, V (basrarasin I, II, III, IV, V).
6, vitamins contains riboflavin, vitamin C, Buddhist nun's acid, thiamine etc.
7, inorganic elements
Contain Ba, Be, Ce, Co, Cr, Cu, Ca, La, Li, Mn, No, Ni, P, Sr, Th, V, Y, Yb, Zn etc.Wherein P content is the highest, and Fe, Zn, Cu, Co, Cr content are also higher.
8, other composition
Carbohydrate 14.4%, crude fibre 0.9%, carotene, choline (choline), iodine matter polyphenol oxidase (polyphenoloxidase), allantoin (allantoin), phlegmatic temperament (maclage), phytic acid (phyticacid) etc.
Traditional medicine is thought Rhizoma Dioscoreae nature and flavor hardship, flat, returns spleen, kidney, lung meridian, the spleen reinforcing nourishing the stomach, and the effects such as lung benefiting of promoting the production of body fluid are used for that insufficiency of the spleen lack of appetite, the deficiency of the lung are breathed with cough, frequent micturition, deficiency-heat are quenched one's thirst etc.The traditional Chinese medical science is used for the enhance immunity ability more, and promoting the production of body fluid to quench thirst, blood sugar lowering etc. are generally acknowledged by masses.
Modern study proves, can strengthen humoral immunization and cellular immunization; Alloxan is caused the prevention and the therapeutical effect of mice diabetes, and can resist the mouse blood sugar rising that causes by epinephrine or glucose: improve Peroxidase activity, reduce lipid peroxide (LPO) content; Also have effects such as accelerated wound healing.
The hypoglycemic activity of Rhizoma Dioscoreae:
1, to the influence of alloxan diabetes mouse blood sugar.
The Rhizoma Dioscoreae water decoction can significantly reduce the blood glucose of the mice of normal mouse and alloxan diabetes.Rhizoma Dioscoreae water decoction 30,60g/kg give mouse stomach, every day 1 time or twice, continuous 10 days, can reduce the blood glucose of normal mouse; The mice diabetes that alloxan is caused have prevention and therapeutical effect.
2, the influence that raises of prevention administration mouse blood sugar that the alloxan purport is risen.
Rhizoma Dioscoreae prevention administration can resist the mouse blood sugar rising that alloxan causes.Mouse stomach Rhizoma Dioscoreae water decoction 30,60g/kg, continuous 10 days, after the last administration 3 hours, administration group and control group mice intravenous injection alloxan 90mg/kg.Get blood after 72 hours and survey blood glucose, administration group blood glucose is starkly lower than reference substance, shows that Rhizoma Dioscoreae prevention administration can resist the mouse blood sugar rising that alloxan causes.
3, the influence that raises of the mouse blood sugar that glucose is caused.
Rhizoma Dioscoreae can be resisted the mouse blood sugar rising that the external source glucose causes.Mice gives Rhizoma Dioscoreae water decoction 30g/kg every day, after the last administration 1 hour, lumbar injection glucose 2g/kg, the injection back was measured blood glucose in 30,60,120 minutes, administration group as a result is starkly lower than matched group at the blood glucose of different time, shows the mouse blood sugar rising effect that Rhizoma Dioscoreae has antagonism external source glucose to cause.
4, the influence that raises of the mouse blood sugar that epinephrine is caused.
Mice gives the Rhizoma Dioscoreae water decoction, continuous 10 days of 30g/kg, and after the last administration 2.5 hours, epinephrine added Rhizoma Dioscoreae group lumbar injection epinephrine 0.2mg/kg, and matched group gives normal saline.Inject back 30 minutes measuring blood sugar of blood extracting.The result shows: Rhizoma Dioscoreae water decoction 60g/kg, continuous 10 days.The mouse blood sugar that can obviously cause antiadrenergic drug raises.
Hypoglycemic health-care polypeptide food is to hyperglycemia rabbit blood sugar reducing function
One, test objective:
Whether this verification experimental verification hypoglycemic health-care polypeptide food has blood sugar reducing function.
Two, test material:
1, is subjected to the reagent thing: hypoglycemic health-care polypeptide food.
2, animal: rabbit, the big ear of Japan is white, body weight 1.6-2.2kg, male and female are nearly half, and the quality certification number is provided by animal housing of Shenyang Pharmaceutical University: the Liao Dynasty is real movingly closes word No. 033.
Three, test method and result:
Get 40 of rabbit, fasting is after 16 hours, and ear edge vein exploitating blood 1.5ml surveys the euglycemia value, chooses the rabbit of blood glucose value in the 3.0-5.0mMol/L scope, injects with 50mg/kg alloxan auricular vein.After 5 days, weigh earlier, fasting is 16 hours then, gets blood and surveys blood glucose value, chooses 24 of the close rabbit of blood glucose value, be divided into 3 groups by blood glucose value and body weight equilibrium, that is, alloxan hyperglycemia model group (50mg/kg), hypoglycemic health-care polypeptide food group (0.56g/kg), other establishes normal blank group, 8 every group.Gastric infusion, every day 1 time, continuous 14 days, respectively at weighing in the 7th day and the 14th day behind the medicine, fasting was got blood again and is surveyed blood glucose value in the time of 16 days then, and data are organized a t check, the results are shown in Table 1.
(the group number of animals dosage of X ± SD) is 16h blood glucose value (mMol/L) on an empty stomach in the influence of table 1 pair rabbit diabetes model
(only) be 14 days normal 8 Ns such as capacity such as grade 3.94 ± 0.54 5.69 ± 0.77 such as 3.88 ± 0.57 3.85 ± 0.48 3.85 ± 0.48 3.88 ± 0.51 alloxan such as blank 8 Ns such as capacity such as grade behind 7 days medicines behind the medicine after the moulding before the moulding (g/kg)
△ △5.58 ± 0.49
△ △5.64 ± 1.16
△Alloxan+hypoglycemic health-care polypeptide food 8 0.56 3.99 ± 0.45 5.85 ± 0.74 4.52 ± 0.51
*4.47 ± 0.53
*Compare with the blank group, △ P＜0.05, compare with the alloxan group △ △ P＜0.01
*P＜0.05,
*P＜0.01
Conclusion:
Alloxan 50mg/kg causes the rabbit hyperglycemia, gavages hypoglycemic health-care polypeptide food (0.56g/kg) 14 days then continuously, gets blood and surveys blood glucose, and the result shows to have significant blood sugar reducing function.
In sum as can be known by casein hydrolysate, Ca
2+, Fe
2+, Zn
2+With the health product that Rhizoma Dioscoreae powder is mixed with, select materials and the compatibility science, have good blood sugar lowering and calcium supplementing effect, be applicable to that hyperglycemia and diabetics take, help the immunologic function of treatment, prevention and the raising human body of diabetics.
Eating method: every day 2-3 time, each 3, half an hour ante cibum is edible.
The manufacture method of hypoglycemic health-care polypeptide food is:
Get casein hydrolysate, calcium lactate, zinc lactate, casein hydrolysate, Rhizoma Dioscoreae powder and ferrous lactate by charge ratio, mix through pressing compatibility, with the ethanol of 70-90% concentration, make soft material, cross (10-80 order) sieve series grain, vacuum drying promptly gets hypoglycemic health-care polypeptide food.
The scope of application and effect
This product is applicable to diabetes and hyperglycemia population.
Prove particularly have the patient of microcirculation disturbance to have good effect to non-according to lazy type diabetes patient by 256 routine diabetics clinic trial, effective percentage reaches 91%.To hyperglycemic patients, on probation through 317 examples, prove effect with significant blood sugar lowering, effective percentage reaches 96%.
(4) specific embodiment
Embodiment one
Hypoglycemic health-care polypeptide food mainly is to be mixed with by casein hydrolysate, Rhizoma Dioscoreae powder, calcium lactate, ferrous lactate, zinc lactate, and its charge ratio is:
Casein hydrolysate 41.2kg, Rhizoma Dioscoreae powder are that 30kg, calcium lactate are with Ca
+Count 28kg, ferrous lactate with Fe
+Count 0.4kg, zinc lactate with Zn
+Count 0.4kg, mix, with the ethanol of 90% concentration, make soft material, cross 6 mesh sieves and granulate, vacuum drying is finished product.
Embodiment two
Hypoglycemic health-care polypeptide food mainly is to be mixed with by casein hydrolysate, Rhizoma Dioscoreae powder, calcium lactate, ferrous lactate and zinc lactate, and its charge ratio is:
Casein hydrolysate is that 15kg, Rhizoma Dioscoreae powder are that 20.6kg, calcium lactate are with Ca
+Count 14kg, ferrous lactate with Fe
+Count 0.3kg, zinc lactate with Zn
+Count 0.1kg, mix, with the ethanol of 90% concentration, make soft material, cross 6 mesh sieves and granulate, vacuum drying is finished product.
Embodiment three
Hypoglycemic health-care polypeptide food mainly is to be mixed with by casein hydrolysate, Rhizoma Dioscoreae powder, calcium lactate, ferrous lactate and zinc gluconate, and its charge ratio is:
Casein hydrolysate is that 2.4kg, Rhizoma Dioscoreae powder are that 25kg, calcium lactate are with Ca
+Count 20kg, ferrous lactate with Fe
+Count 0.4kg, zinc lactate with Zn
+Ion is counted 0.4kg, mixes, and with the ethanol of 90% concentration, makes soft material, crosses 6 mesh sieves and granulates, and vacuum drying is finished product.
Claims (3)
1, hypoglycemic health-care polypeptide food is characterized in that being mixed with by casein hydrolysate, Rhizoma Dioscoreae powder, calcium lactate, ferrous lactate, zinc lactate substantially; The charge ratio of casein hydrolysate, Rhizoma Dioscoreae powder, calcium lactate, ferrous lactate, zinc lactate is that casein hydrolysate is that 15.6-82.4kg, Rhizoma Dioscoreae powder are that 15-60kg, calcium lactate are with Ca
+Ion is counted 12-56kg, ferrous lactate with Fe
+Count 0.2-0.8kg, zinc lactate with Zn
+Count 0.2-0.8kg.
2, the manufacture method of hypoglycemic health-care polypeptide food is characterized in that batching comprises calcium lactate, zinc lactate, casein hydrolysate, Rhizoma Dioscoreae powder and ferrous lactate, and its charge ratio is: casein hydrolysate is that 15.6-82.4kg, Rhizoma Dioscoreae powder are that 15-60kg, calcium lactate are with Ca
+Ion is counted 12-56kg, ferrous lactate with Fe
+Count 0.2-0.8kg, zinc lactate with Zn
+Count 0.2-0.8kg, get material by charge ratio, mix, with the ethanol of 70-90% concentration, make soft material, cross the 60-120 mesh sieve, vacuum drying is finished product.
3, hypoglycemic health-care polypeptide food according to claim 1 is characterized in that casein hydrolysate is that 41.2kg, Rhizoma Dioscoreae powder are that 30kg, calcium lactate are with Ca
+Count 28kg, ferrous lactate with Fe
+Count 0.4kg, zinc lactate with Zn
+Count 0.4kg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02132671A CN1395870A (en) | 2002-07-25 | 2002-07-25 | Hypoglycemic health-care polypeptide food |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02132671A CN1395870A (en) | 2002-07-25 | 2002-07-25 | Hypoglycemic health-care polypeptide food |
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| Publication Number | Publication Date |
|---|---|
| CN1395870A true CN1395870A (en) | 2003-02-12 |
Family
ID=4746877
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN02132671A Pending CN1395870A (en) | 2002-07-25 | 2002-07-25 | Hypoglycemic health-care polypeptide food |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008055801A3 (en) * | 2006-11-06 | 2008-12-04 | Humana Milchunion Eg | Antidiabetogenic calcium-peptide composition |
-
2002
- 2002-07-25 CN CN02132671A patent/CN1395870A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008055801A3 (en) * | 2006-11-06 | 2008-12-04 | Humana Milchunion Eg | Antidiabetogenic calcium-peptide composition |
| EA016545B1 (en) * | 2006-11-06 | 2012-05-30 | Хумана Мильхунион Эг | Use of calcium-peptide composition for preventing and/or treating type ii diabetes |
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