CN1389184A - 人体骨组织生物工程支架制品及其制备方法和用途 - Google Patents
人体骨组织生物工程支架制品及其制备方法和用途 Download PDFInfo
- Publication number
- CN1389184A CN1389184A CN01113076A CN01113076A CN1389184A CN 1389184 A CN1389184 A CN 1389184A CN 01113076 A CN01113076 A CN 01113076A CN 01113076 A CN01113076 A CN 01113076A CN 1389184 A CN1389184 A CN 1389184A
- Authority
- CN
- China
- Prior art keywords
- microparticle
- biotechnological
- bone tissue
- calcium
- phosphorus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 140
- 238000000034 method Methods 0.000 title claims description 15
- 230000008569 process Effects 0.000 title description 5
- 239000011575 calcium Substances 0.000 claims abstract description 55
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 53
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 53
- 239000011574 phosphorus Substances 0.000 claims abstract description 48
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 48
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 47
- 229920000620 organic polymer Polymers 0.000 claims abstract description 40
- 230000000694 effects Effects 0.000 claims abstract description 33
- 230000008929 regeneration Effects 0.000 claims abstract description 20
- 238000011069 regeneration method Methods 0.000 claims abstract description 20
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- 239000011859 microparticle Substances 0.000 claims description 76
- 239000010703 silicon Substances 0.000 claims description 71
- 229910052710 silicon Inorganic materials 0.000 claims description 71
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 62
- 210000004027 cell Anatomy 0.000 claims description 52
- 239000000463 material Substances 0.000 claims description 47
- 210000000963 osteoblast Anatomy 0.000 claims description 25
- 239000000126 substance Substances 0.000 claims description 16
- 230000003321 amplification Effects 0.000 claims description 14
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 14
- 238000009417 prefabrication Methods 0.000 claims description 14
- 230000000975 bioactive effect Effects 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 230000008439 repair process Effects 0.000 claims description 10
- 229920000954 Polyglycolide Polymers 0.000 claims description 9
- 239000003960 organic solvent Substances 0.000 claims description 9
- 238000000338 in vitro Methods 0.000 claims description 7
- 238000002513 implantation Methods 0.000 claims description 6
- 239000004626 polylactic acid Substances 0.000 claims description 6
- 230000008093 supporting effect Effects 0.000 claims description 6
- 238000010276 construction Methods 0.000 claims description 5
- 206010061218 Inflammation Diseases 0.000 claims description 4
- 208000027418 Wounds and injury Diseases 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 230000000399 orthopedic effect Effects 0.000 claims description 4
- 239000004633 polyglycolic acid Substances 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 238000009825 accumulation Methods 0.000 claims description 3
- 238000010079 rubber tapping Methods 0.000 claims description 3
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 claims description 2
- 230000002950 deficient Effects 0.000 claims description 2
- 210000002570 interstitial cell Anatomy 0.000 claims description 2
- 208000002847 Surgical Wound Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 239000002131 composite material Substances 0.000 abstract description 42
- 230000001939 inductive effect Effects 0.000 abstract description 21
- 230000007547 defect Effects 0.000 abstract description 12
- 230000004069 differentiation Effects 0.000 abstract description 9
- 239000013543 active substance Substances 0.000 abstract description 7
- 210000002449 bone cell Anatomy 0.000 abstract description 2
- 230000006698 induction Effects 0.000 abstract description 2
- 230000017423 tissue regeneration Effects 0.000 abstract description 2
- 239000004531 microgranule Substances 0.000 abstract 2
- 230000010478 bone regeneration Effects 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
- 238000009418 renovation Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 25
- 210000001519 tissue Anatomy 0.000 description 25
- 239000000047 product Substances 0.000 description 19
- 230000004071 biological effect Effects 0.000 description 13
- 208000004434 Calcinosis Diseases 0.000 description 12
- 102000004067 Osteocalcin Human genes 0.000 description 11
- 108090000573 Osteocalcin Proteins 0.000 description 11
- 239000012620 biological material Substances 0.000 description 11
- 239000002994 raw material Substances 0.000 description 11
- 238000010171 animal model Methods 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 10
- 230000002308 calcification Effects 0.000 description 10
- 230000028327 secretion Effects 0.000 description 10
- -1 silicon ion Chemical class 0.000 description 10
- 230000011164 ossification Effects 0.000 description 9
- 210000004409 osteocyte Anatomy 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 238000003786 synthesis reaction Methods 0.000 description 8
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 7
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 7
- 239000008187 granular material Substances 0.000 description 7
- 108010048734 sclerotin Proteins 0.000 description 7
- 238000009826 distribution Methods 0.000 description 6
- 239000007943 implant Substances 0.000 description 6
- 239000002105 nanoparticle Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 230000035790 physiological processes and functions Effects 0.000 description 6
- 229910000389 calcium phosphate Inorganic materials 0.000 description 5
- 239000001506 calcium phosphate Substances 0.000 description 5
- 235000011010 calcium phosphates Nutrition 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 150000001993 dienes Chemical class 0.000 description 5
- 229920000747 poly(lactic acid) Polymers 0.000 description 5
- 229920006389 polyphenyl polymer Polymers 0.000 description 5
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 5
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 4
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000003513 alkali Substances 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 230000018678 bone mineralization Effects 0.000 description 4
- 229910000394 calcium triphosphate Inorganic materials 0.000 description 4
- 239000012930 cell culture fluid Substances 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000000250 revascularization Effects 0.000 description 4
- 229910052814 silicon oxide Inorganic materials 0.000 description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- 102000016359 Fibronectins Human genes 0.000 description 3
- 108010067306 Fibronectins Proteins 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000005312 bioglass Substances 0.000 description 3
- 230000008468 bone growth Effects 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000002642 osteogeneic effect Effects 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 2
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 2
- 108010073975 Brinolase Proteins 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 229910004298 SiO 2 Inorganic materials 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 239000005864 Sulphur Substances 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 230000019552 anatomical structure morphogenesis Effects 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 230000031018 biological processes and functions Effects 0.000 description 2
- 210000003969 blast cell Anatomy 0.000 description 2
- 229940112869 bone morphogenetic protein Drugs 0.000 description 2
- 229960002473 brinase Drugs 0.000 description 2
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 2
- 239000000292 calcium oxide Substances 0.000 description 2
- MWKXCSMICWVRGW-UHFFFAOYSA-N calcium;phosphane Chemical compound P.[Ca] MWKXCSMICWVRGW-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 229910052729 chemical element Inorganic materials 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000002224 dissection Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000002138 osteoinductive effect Effects 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 238000009288 screen filtration Methods 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 238000012876 topography Methods 0.000 description 2
- 238000009827 uniform distribution Methods 0.000 description 2
- 229930192334 Auxin Natural products 0.000 description 1
- 102000008138 Bone Morphogenetic Protein 3 Human genes 0.000 description 1
- 108010049951 Bone Morphogenetic Protein 3 Proteins 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 101000573945 Coccidioides posadasii (strain C735) Neutral protease 2 homolog MEP2 Proteins 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001484259 Lacuna Species 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000002363 auxin Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229920005601 base polymer Polymers 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000005313 bioactive glass Substances 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 210000002082 fibula Anatomy 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 239000002241 glass-ceramic Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000012308 immunohistochemistry method Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 230000002632 myometrial effect Effects 0.000 description 1
- 239000002114 nanocomposite Substances 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000002188 osteogenic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 229950000845 politef Drugs 0.000 description 1
- 238000012667 polymer degradation Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000001124 posttranscriptional effect Effects 0.000 description 1
- 230000004537 potential cytotoxicity Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000006557 surface reaction Methods 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30988—Other joints not covered by any of the groups A61F2/32 - A61F2/4425
- A61F2/3099—Other joints not covered by any of the groups A61F2/32 - A61F2/4425 for temporo-mandibular [TM, TMJ] joints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30224—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30242—Three-dimensional shapes spherical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30261—Three-dimensional shapes parallelepipedal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0071—Three-dimensional shapes spherical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0082—Three-dimensional shapes parallelepipedal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Dispersion Chemistry (AREA)
- Composite Materials (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Description
2星期 +1mm <----材料侧硅 14.78 4.12钙 28.37 8.70磷 7.31 7.88硫 7.81 24.26氯 24.99 0 | 材料与动物机体界面 | 机体侧 ----> +1mm ---> +2mm8.79 13.92 2.099.01 14.47 9.478.47 11.64 18.5111.88 15.47 31.900 0 0 |
8星期 <----材料侧硅 12.72 21.22钙 56.64 37.96磷 17.76 34.45硫 0 0氯 0 0 | 机体侧---->0.41 0.58 0.2964.63 59.93 59.4432.40 35.95 37.960 0 00 0 0 |
Claims (36)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011130768A CN1294885C (zh) | 2001-06-05 | 2001-06-05 | 人体骨组织生物工程支架制品及其制备方法和用途 |
PCT/CN2002/000389 WO2002098474A1 (fr) | 2001-06-05 | 2002-06-04 | Produit d'echafaudage dans le domaine du genie tissulaire osseux humain, ses procedes de preparation et ses applications |
DE60238335T DE60238335D1 (de) | 2001-06-05 | 2002-06-04 | Gerüstprodukt für die konstruktion von menschlichem knochengewebe, verfahren zu seiner herstellung |
JP2003501511A JP4391815B2 (ja) | 2001-06-05 | 2002-06-04 | ヒト骨組織工学のための足場、その調製方法およびそれらの使用 |
US10/479,813 US20040191292A1 (en) | 2001-06-05 | 2002-06-04 | Scaffold product for human bone tissue engineering, methods for its preparation and uses thereof |
EP02742644A EP1426066B1 (en) | 2001-06-05 | 2002-06-04 | Scaffold product for human bone tissue engineering, methods for its preparation |
AT02742644T ATE488257T1 (de) | 2001-06-05 | 2002-06-04 | Gerüstprodukt für die konstruktion von menschlichem knochengewebe, verfahren zu seiner herstellung |
RU2003137823/15A RU2308974C2 (ru) | 2001-06-05 | 2002-06-04 | Каркасы для инженерии костной ткани человека, способы их изготовления и их применение |
ES02742644T ES2356304T3 (es) | 2001-06-05 | 2002-06-04 | Producto de armazón para ingeniería de tejido óseo humano, procedimientos para su preparación. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011130768A CN1294885C (zh) | 2001-06-05 | 2001-06-05 | 人体骨组织生物工程支架制品及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1389184A true CN1389184A (zh) | 2003-01-08 |
CN1294885C CN1294885C (zh) | 2007-01-17 |
Family
ID=4659819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB011130768A Expired - Lifetime CN1294885C (zh) | 2001-06-05 | 2001-06-05 | 人体骨组织生物工程支架制品及其制备方法和用途 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20040191292A1 (zh) |
EP (1) | EP1426066B1 (zh) |
JP (1) | JP4391815B2 (zh) |
CN (1) | CN1294885C (zh) |
AT (1) | ATE488257T1 (zh) |
DE (1) | DE60238335D1 (zh) |
ES (1) | ES2356304T3 (zh) |
RU (1) | RU2308974C2 (zh) |
WO (1) | WO2002098474A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101810882B (zh) * | 2004-09-24 | 2013-07-24 | Hi-Lex株式会社 | 机体硬组织或软组织诱导性支架材料 |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4353510B2 (ja) * | 2002-09-09 | 2009-10-28 | 株式会社カネカ | 組織再生用支持体及びその製造方法 |
US20070010892A1 (en) * | 2003-08-27 | 2007-01-11 | Makoto Ogiso | Structural body constituted of biocompatible material impregnated with fine bone dust and process for producing the same |
US8852240B2 (en) | 2004-10-25 | 2014-10-07 | Kieran Murphy, Llc | Methods and compositions for fostering and preserving bone growth |
US8420113B2 (en) * | 2005-02-10 | 2013-04-16 | Cordis Corporation | Biodegradable medical devices with enhanced mechanical strength and pharmacological functions |
US20090022811A1 (en) * | 2007-03-07 | 2009-01-22 | Legeros Racquel Z | Mineralized guided bone regeneration membranes and methods of making the same |
CA2685407A1 (en) * | 2007-04-27 | 2008-11-06 | Yale University | Methods and compositions for fostering and preserving bone growth |
JP5350364B2 (ja) * | 2007-04-28 | 2013-11-27 | ヒョンジン ヤン, | 粉末状の足場を用いた細胞間の信号調節による細胞培養方法 |
US9616205B2 (en) | 2008-08-13 | 2017-04-11 | Smed-Ta/Td, Llc | Drug delivery implants |
US10842645B2 (en) | 2008-08-13 | 2020-11-24 | Smed-Ta/Td, Llc | Orthopaedic implant with porous structural member |
US9700431B2 (en) | 2008-08-13 | 2017-07-11 | Smed-Ta/Td, Llc | Orthopaedic implant with porous structural member |
JP5774989B2 (ja) | 2008-08-13 | 2015-09-09 | スメド−ティーエイ/ティーディー・エルエルシー | 整形外科用ねじ |
WO2010019781A1 (en) | 2008-08-13 | 2010-02-18 | Smed-Ta/Td, Llc | Drug delivery implants |
JP5687622B2 (ja) | 2008-08-29 | 2015-03-18 | スメド−ティーエイ/ティーディー・エルエルシー | 整形外科インプラント |
US8614189B2 (en) | 2008-09-24 | 2013-12-24 | University Of Connecticut | Carbon nanotube composite scaffolds for bone tissue engineering |
WO2010058049A1 (es) * | 2008-11-21 | 2010-05-27 | Consejo Superior De Investigaciones Cientificas (Csic) | Preparación de materiales biocompatibles a partir de desechos del proceso de fabricación de cerveza y sus usos |
GB0900269D0 (en) * | 2009-01-08 | 2009-02-11 | Univ Aberdeen | Silicate-substituted hydroxyapatite |
WO2011143187A2 (en) | 2010-05-10 | 2011-11-17 | University Of Connecticut | Lactoferrin -based biomaterials for tissue regeneration and drug delivery |
ES2373286B2 (es) * | 2010-07-23 | 2013-05-16 | Universidad Complutense De Madrid | Andamio macroporoso cerámico puro basado en apatita nanocristalina, método de preparación y aplicaciones. |
RU2473352C2 (ru) | 2011-04-21 | 2013-01-27 | Закрытое акционерное общество "Институт прикладной нанотехнологии" | Состав, имитирующий внутрисуставную жидкость, и способ получения добавки к ней |
US9180223B2 (en) | 2012-05-10 | 2015-11-10 | The Trustees Of The Stevens Institute Of Technology | Biphasic osteochondral scaffold for reconstruction of articular cartilage |
CN102973334A (zh) * | 2012-12-24 | 2013-03-20 | 天津大学 | 颅骨组织工程支架仿生设计方法 |
US20140186441A1 (en) * | 2012-12-28 | 2014-07-03 | DePuy Synthes Products, LLC | Composites for Osteosynthesis |
US9408699B2 (en) | 2013-03-15 | 2016-08-09 | Smed-Ta/Td, Llc | Removable augment for medical implant |
US9681966B2 (en) | 2013-03-15 | 2017-06-20 | Smed-Ta/Td, Llc | Method of manufacturing a tubular medical implant |
US9724203B2 (en) | 2013-03-15 | 2017-08-08 | Smed-Ta/Td, Llc | Porous tissue ingrowth structure |
US9486483B2 (en) * | 2013-10-18 | 2016-11-08 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
EP3669902B1 (fr) * | 2018-12-20 | 2021-04-28 | Ralphe Badaoui | Dispositif de regeneration osseuse guidee et procede de fabrication |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT352867B (de) * | 1976-05-12 | 1979-10-10 | Battelle Institut E V | Knochenersatz-knochenverbund-oder prothesen- verankerungswerkstoff und verfahren zu seiner herstellung |
US4103002A (en) * | 1977-02-08 | 1978-07-25 | Board Of Regents, University Of Florida | Bioglass coated A1203 ceramics |
US5017627A (en) * | 1980-10-09 | 1991-05-21 | National Research Development Corporation | Composite material for use in orthopaedics |
DE3826915A1 (de) * | 1988-08-09 | 1990-02-15 | Henkel Kgaa | Neue werkstoffe fuer den knochenersatz und knochen- bzw. prothesenverbund |
US5074916A (en) * | 1990-05-18 | 1991-12-24 | Geltech, Inc. | Alkali-free bioactive sol-gel compositions |
DE19610715C1 (de) * | 1996-03-19 | 1997-06-26 | Axel Kirsch | Verfahren zum Herstellen eines Knochenersatzmaterials |
US5830480A (en) * | 1996-05-09 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Stabilization of sol-gel derived silica-based glass |
US6051247A (en) * | 1996-05-30 | 2000-04-18 | University Of Florida Research Foundation, Inc. | Moldable bioactive compositions |
FI971385A0 (fi) * | 1997-04-04 | 1997-04-04 | Bioxid Oy | Biokompatibel komposition, metoder foer dess framstaellning samt anvaendning daerav |
US5977204A (en) * | 1997-04-11 | 1999-11-02 | Osteobiologics, Inc. | Biodegradable implant material comprising bioactive ceramic |
DE19721661A1 (de) * | 1997-05-23 | 1998-11-26 | Zimmer Markus | Knochen- und Knorpel Ersatzstrukturen |
AU8825198A (en) * | 1997-08-08 | 1999-03-01 | Us Biomaterials Corporation | Biologically active glass-based substrate |
US6328990B1 (en) * | 1999-11-12 | 2001-12-11 | The Trustees Of The University Of Pennsylvania | Bioactive, degradable composite for tissue engineering |
WO2002083194A1 (en) * | 2001-04-12 | 2002-10-24 | Therics, Inc. | Method and apparatus for engineered regenerative biostructures |
-
2001
- 2001-06-05 CN CNB011130768A patent/CN1294885C/zh not_active Expired - Lifetime
-
2002
- 2002-06-04 EP EP02742644A patent/EP1426066B1/en not_active Expired - Lifetime
- 2002-06-04 RU RU2003137823/15A patent/RU2308974C2/ru active
- 2002-06-04 US US10/479,813 patent/US20040191292A1/en not_active Abandoned
- 2002-06-04 JP JP2003501511A patent/JP4391815B2/ja not_active Expired - Lifetime
- 2002-06-04 DE DE60238335T patent/DE60238335D1/de not_active Expired - Lifetime
- 2002-06-04 AT AT02742644T patent/ATE488257T1/de not_active IP Right Cessation
- 2002-06-04 ES ES02742644T patent/ES2356304T3/es not_active Expired - Lifetime
- 2002-06-04 WO PCT/CN2002/000389 patent/WO2002098474A1/zh active Application Filing
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101810882B (zh) * | 2004-09-24 | 2013-07-24 | Hi-Lex株式会社 | 机体硬组织或软组织诱导性支架材料 |
Also Published As
Publication number | Publication date |
---|---|
DE60238335D1 (de) | 2010-12-30 |
ES2356304T3 (es) | 2011-04-06 |
CN1294885C (zh) | 2007-01-17 |
JP4391815B2 (ja) | 2009-12-24 |
JP2005506114A (ja) | 2005-03-03 |
EP1426066A1 (en) | 2004-06-09 |
EP1426066B1 (en) | 2010-11-17 |
ATE488257T1 (de) | 2010-12-15 |
WO2002098474A1 (fr) | 2002-12-12 |
EP1426066A4 (en) | 2006-01-11 |
US20040191292A1 (en) | 2004-09-30 |
RU2003137823A (ru) | 2005-03-27 |
RU2308974C2 (ru) | 2007-10-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1294885C (zh) | 人体骨组织生物工程支架制品及其制备方法和用途 | |
Dolcimascolo et al. | Innovative biomaterials for tissue engineering | |
Rahaman et al. | Bioactive glass in tissue engineering | |
US7968026B1 (en) | Three-dimensional bioresorbable scaffolds for tissue engineering applications | |
US6277151B1 (en) | Cartilage growth from cell seeded ceramic compositions | |
CN102089238B (zh) | 用于组织工程和骨再生的结构化多孔三斜磷钙石的三维基质及其制备方法 | |
CN100522265C (zh) | 具有仿生功能界面骨软骨复合组织一体化工程支架 | |
Yao et al. | Calvarial bone response to a tricalcium phosphate-genipin crosslinked gelatin composite | |
Dellinger et al. | Bone response to 3D periodic hydroxyapatite scaffolds with and without tailored microporosity to deliver bone morphogenetic protein 2 | |
US20100234966A1 (en) | Bone repair or augmentation device | |
MX2014014656A (es) | Dispositivos de reparacion de tejido y andamiajes. | |
Peng et al. | A novel porous bioceramics scaffold by accumulating hydroxyapatite spherules for large bone tissue engineering in vivo. I. Preparation and characterization of scaffold | |
Adel‐Khattab et al. | Development of a synthetic tissue engineered three‐dimensional printed bioceramic‐based bone graft with homogenously distributed osteoblasts and mineralizing bone matrix in vitro | |
CN108853578A (zh) | 一种3D打印Ti-水凝胶-成骨细胞骨组织工程支架及其制备方法 | |
CA3055688A1 (en) | Tissue engineering scaffolds | |
Li et al. | Microstructural orientation and precise regeneration: A proof-of-concept study on the sugar-cane-derived implants with bone-mimetic hierarchical structure | |
Huang et al. | Preparation and characterization of digital coral hydroxyapatite artificial bone scaffolds based on 3D printing | |
Taylor et al. | Recent advances in bone graft technologies | |
Dellinger | Development of model hydroxyapatite bone scaffolds with multiscale porosity for potential load bearing applications | |
Farahi et al. | Evaluation of possible beneficial effect of tricalcium phosphate/collagen (TCP/Collagen) nanocomposite scaffold on bone healing in rabbits: biochemical assessments | |
CN104707182B (zh) | 椎间植入物 | |
Mahanani et al. | The proper design of scaffold porosity for bone regeneration (literature review) | |
Thomas et al. | Tissue Engineering Systems | |
Tan et al. | Characterisation of calcium phosphate cement-derived hydroxyapatite scaffolds with a PLGA-bioactive glass composite coating | |
Dolcimascolo et al. | and Rosalba Parenti |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: JIANGSU YANGSHENG BIOLOGY ENGINEERING CO., LTD. Free format text: FORMER OWNER: SHANGHAI LAISHENG BIOTECHNOLOGY CO., LTD. Effective date: 20030522 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20030522 Address after: 214431 Binjiang Development Zone, Jiangsu, Jiangyin Applicant after: JIANGSU YENSSEN BIOTECH CO., LTD. Address before: 201100 Shanghai City Industrial Zone Xhenzhuang humin Road No. 6555 Applicant before: Shanghai Laisheng Biotechnology Co., Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: JIANGSU YANGSHENG BIOTECHNOLOGY CO., LTD. Free format text: FORMER NAME: JIANGSU YANGSHENG BIOLOGICAL ENGINEERING CO., LTD. |
|
CP01 | Change in the name or title of a patent holder |
Address after: 214431 Binjiang Development Zone, Jiangsu, Jiangyin Patentee after: Jiangsu Yang Sheng biological Limited by Share Ltd Address before: 214431 Binjiang Development Zone, Jiangsu, Jiangyin Patentee before: JIANGSU YENSSEN BIOTECH CO., LTD. |
|
CX01 | Expiry of patent term |
Granted publication date: 20070117 |
|
CX01 | Expiry of patent term |