CN1387889A - Chinese medicine prepn for treating deficiency of spleen and stomach Yin type atrophic gastritis - Google Patents

Abstract

The present invention relates to Chinese medicine compounding technology and aims at providing one Chinese medicine preparation for treating spleen and stomach Yin-deficiency type atrophic gastritis in obvious curative effect and less toxic side effect. The Chinese medicine preparation has the material composition including Codonopsis Pilosulae, dry organe peel, Chinese yam, ginger, figwort and other six kinds of Chinese medicinal material. It is in two forms of capsule and granule. It has obvious treating effect to chronic superficial gastritis and atrophic gastritis.

Description

The Chinese medicine preparation of treatment deficiency of spleen and stomach Yin type atrophic gastritis

Technical field: the invention belongs to the Chinese medicine complex preparation, particularly a kind of Chinese medicine preparation for the treatment of deficiency of spleen and stomach Yin type atrophic gastritis.

Background technology: atrophic gastritis is a kind of of chronic gastritis, because the conversion ratio of its gastric cancer is higher, so often be counted as the cercinoma prophase pathologic change of gastric cancer.Therefore, atrophic gastritis is the disease of a kind of serious harm health and safety.According to the theory of the traditional Chinese medical science " dialectical executing controlled, YIN and YANG in a relative equilibrium ", but the atrophic gastritis medicine typing is deficiency of spleen and stomach Yang type and deficiency of spleen and stomach Yin type.The tcm diagnosis standard of deficiency of spleen and stomach Yin type atrophic gastritis is: type of deficiency of stomach yin stomachache, burning pain in the epigastrium, xerostomia happiness are cold, appetite stimulator, constipation with dry stool, upset in the stomach, few, the thready pulse of red tongue tongue.At present, the medicine that is used for the treatment of chronic gastritis is a lot, as MOLUO DAN, WEIFUCHUN, SANJIU WEITAI etc., though all have certain curative effect, do not control because it carries out the medicine typing opinion, so be difficult to suit the remedy to the case, therefore, its therapeutic effect is not quite desirable, and curative effect is not high.

Summary of the invention: technical problem to be solved by this invention is: according to the traditional Chinese medical science " dialectical medication ", the theory of " suiting the remedy to the case ", chronic gastritis is carried out medicine typing opinion control, a kind of Chinese medicine preparation of evident in efficacy, the stable and treatment deficiency of spleen and stomach Yin type atrophic gastritis that has no side effect is provided.

Its technical scheme is: a kind of Chinese medicine preparation for the treatment of deficiency of spleen and stomach Yin type atrophic gastritis is characterized in that its raw material components percentage by weight is:

Radix Codonopsis 5-15 Pericarpium Citri Reticulatae 4-12 Rhizoma Dioscoreae 5-15 Rhizoma Zingiberis 1-5

Radix Scrophulariae 5-15 Fructus Mume 7-16 Radix Glehniae 5-15 Rhizoma Polygonati (steaming) 5-15

The Rhizoma Atractylodis Macrocephalae (stir-fry) 5-15 Fructus Crataegi (stir-fry) 5-15 field dobber (decocting a drug wrapped) 5-15

Radix Codonopsis, Rhizoma Dioscoreae, Rhizoma Polygonati QI invigorating are set upright and are principal agent in the side, and the regulating immunological function microcirculation improvement is repaired gastric mucosa, and the atrophy body of gland is had restitution.The Rhizoma Atractylodis Macrocephalae can anti-helicobacter pylori, suppresses bile reflux, strengthens the merit of holding up the spleen stomach reinforcing.Fructus Mume, Fructus Crataegi are promoted the production of body fluid aid digestion, two-ways regulation gastric acid secretion function.The hot-tempered product of Radix Scrophulariae, Radix Glehniae, field dobber isothermal form nourishing YIN can supplementing QI and nourishing YIN.

This preparation is production technology routinely, can make two kinds of dosage forms of capsule and electuary respectively, so that take.

This preparation has the merit of anti-inflammatory and antalgic, stomach reinforcing QI invigorating, strengthening the body resistance; gastric mucosa and anti-gastric mucosa injury had tangible reparation, protective effect; the gastritis model that freund adjuvant is caused has therapeutical effect preferably; lesion degrees such as gastric mucosal erosion, chronic inflammation cellular infiltration, hyperemia are alleviated or the incidence rate minimizing; alleviate and recover the atrophy of gastric gland body, improve stomach and secrete acid, facilitating digestion liquid and digestive enzyme secretion; strengthen gastric motility, strengthen and recovery immunity.

Be the patient of deficiency of spleen and stomach Yin type chronic superficial gastritis and atrophic gastritis through 60 examples are clarified a diagnosis, be divided into two groups at random, take capsule and electuary (its dosage and contain the crude drug amount suitable) respectively.Capsules group 30 examples, wherein atrophic gastritis 16 examples have 6 examples to observe half a year, superficial gastritis 14 examples; The oldest 62 years old, minimum 24 years old; The course of disease is the shortest 10 months, and is the longest 20 years, electuary group 30 examples, and wherein atrophic gastritis 15 examples have 7 examples to observe half a year, superficial gastritis 15 examples; The oldest 61 years old, minimum 26 years old, the course of disease is the shortest 6 months, and was the longest 14 years.Its symptom total effects sees Table 1.

Table 1

	The example number	Produce effects	Effectively	Invalid	Total effective rate (%)
						Capsules group electuary group	????30	????6	????20	????4	????86.67
????30	????5	????21	????4	????86.67

Its sick curative effect of planting sees Table 2.Table 2

	Superficial gastritis		Atrophic gastritis
							Two months		Two months		Six months
	Capsules group	The electuary group	Capsules group	The electuary group	Capsules group	The electuary group
							The example number	????14	????15	????16	????15	????6	????7
Produce effects	????3	????3	????3	????2	????2	????1
							Effectively	????10	????10	????10	????11	????3	????5
Invalid	????1	????2	????3	????2	????1	????1
							Total effective rate (%)	????92.85	????86.67	????81.25	????86.67	????83.33	????85.71

Its cardinal symptom curative effect sees Table 3.Table 3

		The example number	Produce effects	Effectively	Invalid	Total effective rate (%)
							Gastric cardialgia	The electuary group	29	?11	?14	????4	??86.21
Capsules group	30	?13	?14	????3	??90
						Desire for cold drinks		The electuary group	22	?8	?10	????4	??81.82
Capsules group	23	?10	?10	????3	??86.96
							Dry mouth and tougue	The electuary group	26	?10	?13	????3	??88.46
Capsules group	27	?13	?10	????4	??85.19
						Feverish sensation in the palms and soles		The electuary group	20	?8	?9	????3	??85
Capsules group	20	?10	?8	????2	??90

Its gastroscopy effect sees Table 4.Table 4

	Superficial gastritis		Atrophic gastritis
							Two months		Two months		Six months
	Capsules group	The electuary group	Capsules group	The electuary group	Capsules group	The electuary group
							The example number	????14	????15	????16	????15	????6	????7
Produce effects	????3	????3	????1	????2		????1
							Effectively	????9	????9	????10	????7	????4	????4
Invalid	????2	????3	????5	????6	????2	????2
							Total effective rate (%)	????85.71	????80	????71.42	????68.75	????66.67	????71.42

Through clinical observation more than a year, this preparation is not found side effect, and check routine blood test, liver, renal function etc. do not find that it has infringement to important organs such as the blood system heart, Liver and kidney before and after the treatment.Check table 5 is seen in its safety.

Table 5

	The unusual case load of Capsules group		The unusual case load of electuary group
						Before the treatment	After the treatment	Before the treatment	After the treatment
??HB	????0	????0	????0	????0
					??WBC	????0	????0	????0	????0
??RBC	????0	????0	????0	????0
					??SGPT	????0	????0	????0	????0
??RUN	????0	????0	????0	????0
					??CR	????0	????0	????0	????0
??OB	????0	????0	????0	????0

In sum, this Chinese medicine preparation, no matter be capsule or electuary, treatment YIN-deficiency type chronic superficial gastritis and atrophic gastritis all there are definite curative effect and significant effect, clinical application is extensive, safety, and having no side effect, the curative effect proper extension of YIN-deficiency type atrophic gastritis is more helped to improve curative effect its course of treatment, is the important breakthrough of treatment by Chinese herbs atrophic gastritis.

Embodiment:

Embodiment 1: get Radix Codonopsis 5Kg, Rhizoma Dioscoreae 15kg, Rhizoma Polygonati (steaming) 15kg, Pericarpium Citri Reticulatae 4kg, Rhizoma Zingiberis 1kg, Radix Scrophulariae 5kg, Fructus Mume 16kg, Radix Glehniae 5kg, the Rhizoma Atractylodis Macrocephalae (stir-fry) 5kg, Fructus Crataegi (stir-fry) 5kg, field dobber (decocting a drug wrapped) 5kg.

Production technology is made capsule or electuary dosage form routinely.

Embodiment 2: get Radix Codonopsis 10kg, Rhizoma Dioscoreae 10kg, Rhizoma Polygonati (steaming) 10kg, Pericarpium Citri Reticulatae 8kg, Rhizoma Zingiberis 3kg, Radix Scrophulariae 10kg, Fructus Mume 12kg, Radix Glehniae 10kg, the Rhizoma Atractylodis Macrocephalae (stir-fry) 10kg, Fructus Crataegi (stir-fry) 10kg, field dobber (decocting a drug wrapped) 10kg, production technology is made capsule or electuary dosage form routinely.

Embodiment 3: get Radix Codonopsis 15kg, Rhizoma Dioscoreae 5kg, Rhizoma Polygonati (steaming) 5kg, Pericarpium Citri Reticulatae 12kg, Rhizoma Zingiberis 4kg, Radix Scrophulariae 15kg, Fructus Mume 7kg, Radix Glehniae 15kg, the Rhizoma Atractylodis Macrocephalae (stir-fry) 15kg, Fructus Crataegi (stir-fry) 15kg, field dobber (decocting a drug wrapped) 15kg, connect conventional production process and make capsule or electuary dosage form.

Claims (2)

1, a kind of Chinese medicine preparation for the treatment of deficiency of spleen and stomach Yin type atrophic gastritis is characterized in that its raw material components percentage by weight is:

Radix Codonopsis 5-15 Pericarpium Citri Reticulatae 4-12 Rhizoma Dioscoreae 5-15 Rhizoma Zingiberis 1-5

Radix Scrophulariae 5-15 Fructus Mume 7-16 Radix Glehniae 5-15 Rhizoma Polygonati (steaming) 5-15

The Rhizoma Atractylodis Macrocephalae (stir-fry) 5-15 Fructus Crataegi (stir-fry) 5-15 field dobber (decocting a drug wrapped) 5-15

2,, it is characterized in that described preparation is capsule and two kinds of dosage forms of electuary as weighing 1 described a kind of Chinese medicine preparation.