CN1383863A - Medicine for treating cough and asthma and its prepn - Google Patents
Medicine for treating cough and asthma and its prepn Download PDFInfo
- Publication number
- CN1383863A CN1383863A CN02112833A CN02112833A CN1383863A CN 1383863 A CN1383863 A CN 1383863A CN 02112833 A CN02112833 A CN 02112833A CN 02112833 A CN02112833 A CN 02112833A CN 1383863 A CN1383863 A CN 1383863A
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- medicine
- asthma
- fine powder
- cough
- mixing
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Links
- 206010011224 Cough Diseases 0.000 title claims abstract description 41
- 208000006673 asthma Diseases 0.000 title claims abstract description 28
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 229940079593 drug Drugs 0.000 title description 5
- 239000000843 powder Substances 0.000 claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 210000000582 semen Anatomy 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 12
- 208000026435 phlegm Diseases 0.000 abstract description 12
- 206010006451 bronchitis Diseases 0.000 abstract description 8
- 238000009825 accumulation Methods 0.000 abstract description 6
- 210000004072 lung Anatomy 0.000 abstract description 5
- 206010006458 Bronchitis chronic Diseases 0.000 abstract description 4
- 206010014561 Emphysema Diseases 0.000 abstract description 4
- 208000004186 Pulmonary Heart Disease Diseases 0.000 abstract description 4
- 230000001154 acute effect Effects 0.000 abstract description 4
- 208000007451 chronic bronchitis Diseases 0.000 abstract description 4
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 2
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 2
- 244000236658 Paeonia lactiflora Species 0.000 abstract 2
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 2
- 244000144725 Amygdalus communis Species 0.000 abstract 1
- 235000011437 Amygdalus communis Nutrition 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 235000020224 almond Nutrition 0.000 abstract 1
- 230000000210 effect on cough Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 7
- 239000003172 expectorant agent Substances 0.000 description 6
- 230000003419 expectorant effect Effects 0.000 description 6
- 208000037656 Respiratory Sounds Diseases 0.000 description 5
- 206010036790 Productive cough Diseases 0.000 description 4
- 208000024794 sputum Diseases 0.000 description 4
- 210000003802 sputum Anatomy 0.000 description 4
- 201000006306 Cor pulmonale Diseases 0.000 description 3
- 206010037833 rales Diseases 0.000 description 3
- 206010047924 Wheezing Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241001092070 Eriobotrya Species 0.000 description 1
- 235000009008 Eriobotrya japonica Nutrition 0.000 description 1
- 241000935235 Fritillaria meleagris Species 0.000 description 1
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 229960002335 bromhexine hydrochloride Drugs 0.000 description 1
- 229940045348 brown mixture Drugs 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- YRSGDLIATOURQO-UHFFFAOYSA-N ethyl 4-acetyl-5-oxohexanoate Chemical compound CCOC(=O)CCC(C(C)=O)C(C)=O YRSGDLIATOURQO-UHFFFAOYSA-N 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000008563 guizhi decoction Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229960003910 promethazine Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The medicine for treating cough and asthma is prepared with cassia twig, white peony root, fossil fragments, osyter, almond and prepared licorice. During its preparation, cassia twig and half of white peony root are ground, sieved and mixed into fine powder; the other medicine materials are thrice decocted, the decoction liquid is merged, filtered, concentrated and mixed wite the fine powder; and the mixture is dried at low temperature, crushed, sieved, mixed and capsulized. Clinical application shows that the medicine has high curative effect on cough, asthma, acute and chronic bronchitis, bronchial asthma, emphysema, pulmonary heart diseases, etc. caused by affection due to external wind and cold and accumulation of phlegm-dampness in the lung.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of cough and asthma and preparation method thereof, be specifically a kind of be the pure Chinese medicinal preparation and preparation method thereof of cough and asthmas such as the treatment cold cough made of raw material, acute/chronic bronchitis, bronchial asthma, emphysema, pulmonary heart disease with the natural Chinese medicinal herb.
Background technology
Flu is a kind of the most common and multiple disease, acute/chronic bronchitis, bronchial asthma and the cough that causes by catching a cold, asthma, accumulation and obstruction of sputum etc. are difficult to rapidly especially, thoroughly radical cure, outbreak repeatedly, can cause the state of an illness to increase the weight of, and develop into emphysema gradually, pulmonary heart disease, primary disease is simulataneous insufficiency and excessive often, the cold and heat cross-reference, inside and outside combined pathogens, the exterior and interior syndromes appearing simultaneously, the serious harm people's life and health.
The medicine of treatment cough commonly used, asthma, accumulation and obstruction of sputum has a lot, and the natural drugs such as Chinese herbal medicine that existing Chinese medicine is used have chemicals again.Since chemicals, as promethazine, bromhexine hydrochloride etc., though the effect that has relieving cough and resolving phlegm, relievings asthma, poor effect, and can produce some side effect, therefore, good effect, the Chinese medicine product that has no side effect just enjoy people's favor.At present, the Chinese patent medicine of treatment cough, asthma, accumulation and obstruction of sputum as fritillary and loquat cough mixture, Radix Glycyrrhizae tabellae, brown mixture etc., has certain effect, cures the symptoms, not the disease but exist, easily deficiency such as outbreak repeatedly.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of cough and asthma and preparation method thereof, it has anti-curing cold, and cuts off old complaint, eliminating phlegm and stopping cough, and lowering the adverse-rising QI to subdue asthma, treating both the principal and the secondary aspects of a disease at the same time prevents the characteristics that recur.
The solution of invention is:
The medicine of treatment cough and asthma, mainly make by following component:
Ramulus Cinnamomi 10-20%,
Radix Paeoniae Alba 10-20%,
Os Draconis 20-30%,
Concha Ostreae 20-30%,
Semen Armeniacae Amarum 10-20%,
Radix Glycyrrhizae Preparata 5-10%.
The preferred component of preparation medicine of the present invention is:
Ramulus Cinnamomi 13.35%,
The Radix Paeoniae Alba 13.35%,
Os Draconis 26.65%,
Concha Ostreae 26.65%,
Semen Armeniacae Amarum 12%,
Radix Glycyrrhizae Preparata 8%.
The present invention can make various dosage forms according to a conventional method.
Preferred a kind of capsule formulation of making by special process in various dosage forms, preparation method is as follows:
A, with Ramulus Cinnamomi with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve mixing;
B, surplus medicine decoct with water three times, and 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time;
C, collecting decoction filter, and it is 1.25-1.30 (60 ℃) that filtrate is concentrated into relative density;
D, add above-mentioned fine powder, mixing, cold drying;
E, be ground into fine powder, sieve, mixing, promptly encapsulated.
The preferred for preparation method:
A, with Ramulus Cinnamomi with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve, mixing, standby;
B, surplus medicine decoct with water three times, and amount of water is respectively 10 times, 8 times, 6 times, and decocting time is 2 hours, and 1 hour, 0.5 hour;
C, collecting decoction filter, and it is 1.25-1.30 (60 ℃ of heat are surveyed) that filtrate is concentrated into relative density;
D, the above-mentioned standby fine powder of adding, mixing, low temperature (below 60 ℃) drying;
E, be ground into fine powder (80-120 order), micropowder (120-12500 order), sieve, mixing, encapsulated (every 0.3 gram) are promptly.
Each flavor is crude drug in the medicine of the present invention, can be used for affection of exogenous wind-cold, and disease such as the cough that accumulation of phlegm-damp in the lung causes, asthma, accumulation and obstruction of sputum and acute/chronic bronchitis, bronchial asthma, emphysema, pulmonary heart disease etc. are seen above-mentioned symptom person.The present invention selects Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Glycyrrhizae, gets the meaning of guizhi decoction, and harmonizing yingfen and weifen, expelling pathogenic factors from muscles are got rid of evils, with control cough with asthma this, and select Os Draconis, Concha Ostreae, Semen Armeniacae Amarum by expectorant sending down the abnormal ascending QI, relieving cough and asthma, to control the mark of cough with asthma.All medicines match and can reach the cut-out old complaint, eliminating phlegm and stopping cough, and lowering the adverse-rising QI to subdue asthma, treating both the principal and the secondary aspects of a disease at the same time prevents the effect that recurs.
Concrete instructions of taking of the present invention and consumption: every day, 3.6-4.5 restrained, and is oral every day 3 times, takes take medicine 1-2 the course of treatment (be 7 each course of treatment) with boiled water.
Specific embodiment
The curative effect clinical statistics:
(1) cardinal symptom, sign criterion:
Cough: light discontinuity cough on (+) daytime does not influence orthobiosis and work;
In (++) apasm of coughing, do not influence sleep;
Heavy (+++) cough frequently round the clock, influence work and sleep;
Cough up phlegm: few (+) cough up phlegm round the clock 6-15 mouth or 20-50 milliliter;
In (++) cough up phlegm round the clock 15-30 mouth or 50-100 milliliter;
Heavy (+++) cough up phlegm round the clock more than 100 milliliters;
Pant: do not pant when gently (+) is quiet, obviously movable back or morning and evening have slightly pants;
In (++) do not pant heavy when quiet, have activity or morning and evening to pant slightly and increase the weight of;
Pant obviously when heavy (+++) is quiet, can not put down night for sleeping in, and the influence sleep is with movable;
Main physical signs---dried, moist rale, wheezing sound;
Few (+) two lungs idol is heard, or occurs in cough, the dark fast back of breathing;
In (++) two lungs be dispersed in;
Heavy (+++) two fullness of the lung cloth.
(2) curative effect determinate standard: the every observation index of binding analysis, to cough, expectorant, to pant and main physical signs is done, moist rale, wheezing sound are main judgment basis.
Clinic control: cough, that expectorant, the symptom of panting and main physical signs are not enough is slight or disappear;
Produce effects: cough, expectorant, the symptom of panting and main physical signs be clearly better, transfer (+) to by (+++);
Take a turn for the better: cough, expectorant, the symptom of panting and main physical signs take a turn for the better, transfer (++) to or (++) transfers (+) to by (+++);
Invalid: as to cough, expectorant, the symptom of panting and main physical signs do not have and change or increase the weight of.
Curative effect clinical data statistics:
(1) total effects:
| Case | Clinic control | Produce effects | Take a turn for the better | Invalid | Effective percentage |
| 73 | ?18 | 28 | 22 | 5 | 93.15％ |
(2) individual event curative effect:
| Disease | Case | Clinic control | Produce effects | Take a turn for the better | Invalid |
| Cough | ??73 | ????18 | ??28 | ??22 | ???5 |
| Pant | ??61 | ????19 | ??23 | ??14 | ???5 |
| Cough up phlegm | ??69 | ????18 | ??26 | ??20 | ???5 |
| Rale | ??55 | ????15 | ??24 | ??13 | ???3 |
(3) differential diagnosis in tcm and therapeutic effect relationship
| Disease | Case | Clinic control | Produce effects | Take a turn for the better | Invalid |
| Wind and cold | 28 | ????8 | 12 | ?7 | ?1 |
| Phlegm-damp | 29 | ??9 | ?12 | ??6 | ??2 |
By above-mentioned clinical data as seen, medicine of the present invention has fabulous curative effect for treatment cough and asthma disease, not only can eliminating phlegm and stopping cough, and lowering the adverse-rising QI to subdue asthma has more anti-curing cold, and cuts off old complaint, and treating both the principal and the secondary aspects of a disease at the same time prevents the characteristics that recur.
Claims (4)
1, the medicine of treatment cough and asthma, mainly make by following component:
Ramulus Cinnamomi 10-20%,
Radix Paeoniae Alba 10-20%,
Os Draconis 20-30%,
Concha Ostreae 20-30%,
Semen Armeniacae Amarum 10-20%,
Radix Glycyrrhizae Preparata 5-10%.
2, the medicine of treatment cough and asthma according to claim 1, its preferred component is:
Ramulus Cinnamomi 13.35%,
The Radix Paeoniae Alba 13.35%,
Os Draconis 26.65%,
Concha Ostreae 26.65%,
Semen Armeniacae Amarum 12%,
Radix Glycyrrhizae Preparata 8%.
3, the preparation method of the medicine of treatment cough and asthma is as follows:
A, with Ramulus Cinnamomi with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve mixing;
B, surplus medicine decoct with water three times, and 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time;
C, collecting decoction filter, and it is 1.25-1.30 (60 ℃) that filtrate is concentrated into relative density;
D, add above-mentioned fine powder, mixing, cold drying;
E, be ground into fine powder, sieve, mixing, promptly encapsulated.
4, the preferred for preparation method of the medicine of treatment cough and asthma according to claim 3:
A, with Ramulus Cinnamomi with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve, mixing, standby;
B, surplus medicine decoct with water three times, and amount of water is respectively 10 times, 8 times, 6 times, and decocting time is 2 hours, and 1 hour, 0.5 hour;
C, collecting decoction filter, and it is 1.25-1.30 (60 ℃ of heat are surveyed) that filtrate is concentrated into relative density;
D, the above-mentioned standby fine powder of adding, mixing, low temperature (below 60 ℃) drying;
E, be ground into fine powder (80-120 order), micropowder (120-12500 order), sieve, mixing, promptly encapsulated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021128332A CN1176686C (en) | 2002-03-28 | 2002-03-28 | Medicine for treating cough and asthma and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021128332A CN1176686C (en) | 2002-03-28 | 2002-03-28 | Medicine for treating cough and asthma and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1383863A true CN1383863A (en) | 2002-12-11 |
| CN1176686C CN1176686C (en) | 2004-11-24 |
Family
ID=4742285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021128332A Expired - Lifetime CN1176686C (en) | 2002-03-28 | 2002-03-28 | Medicine for treating cough and asthma and its prepn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1176686C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113440558A (en) * | 2021-08-17 | 2021-09-28 | 郑小春 | Traditional Chinese medicine composition for treating pneumonia and preparation method thereof |
-
2002
- 2002-03-28 CN CNB021128332A patent/CN1176686C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113440558A (en) * | 2021-08-17 | 2021-09-28 | 郑小春 | Traditional Chinese medicine composition for treating pneumonia and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1176686C (en) | 2004-11-24 |
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| SE01 | Entry into force of request for substantive examination | ||
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: GUILONG MEDICINE (ANHUI) CO., LTD. Free format text: FORMER OWNER: GUILONG MEDICINE CO., LTD., SHANXI Effective date: 20110510 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 034000 ECONOMIC DEVELOPMENT ZONE, XINZHOU CITY, SHANXI PROVINCE TO: 243100 DANGTU INDUSTRIAL PARK, MAANSHAN CITY, ANHUI PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20110510 Address after: 243100 Anhui city of Ma'anshan province Dangtu Industrial Park Patentee after: Guilong Pharmacy (Anhui) Co., Ltd. Address before: 034000 Xinzhou Economic Development Zone, Shanxi Patentee before: Guilong Medicine Co., Ltd., Shanxi |
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| CX01 | Expiry of patent term |
Granted publication date: 20041124 |
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| CX01 | Expiry of patent term |