CN105213615A - Compound Solanum Nigrum Pianomide - Google Patents
Compound Solanum Nigrum Pianomide Download PDFInfo
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- CN105213615A CN105213615A CN201510779246.8A CN201510779246A CN105213615A CN 105213615 A CN105213615 A CN 105213615A CN 201510779246 A CN201510779246 A CN 201510779246A CN 105213615 A CN105213615 A CN 105213615A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses a kind of Compound Solanum Nigrum Pianomide, make primarily of Herba Solani Nigri, Herba Hydrocotyles and Ramulus Et Folium Pithecellobii Lucidi.Preparation method is as follows: to Herba Solani Nigri, and Herba Hydrocotyles and Ramulus Et Folium Pithecellobii Lucidi are ground into coarse powder respectively; Carry out reflux, extract, medical material effective ingredient with ethanol, water successively, obtain extract powder by after concentrated for extracting solution, drying subsequently; By extract powder and adjuvant mixing granulation, compressing, film coating.Compound Solanum Nigrum Pianomide disclosed in this invention has the effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, expelling phlegm for arresting cough, diuretic antidiarrheal, clinically be used for the treatment of upper respiratory tract infection, acute pharyngolaryngitis, acute tonsillitis, infantile common cold fever, cough due to lung-heat, senile chronic tracheitis, bronchial asthma, acute gastroenteritis, hepatitis, dysentery, leukorrhagia, gynecological inflammation, dysuria, gonorrhea, prostatitis, acute nephritis and furuncle sore and toxic, dermatitis and eczema, osteopatia sprain etc., effective in curely obviously, substantially have no side effect, the advantage such as taking convenience.
Description
Technical field
The present invention relates to a kind of technical field of Chinese medicines, especially relate to a kind of Compound Solanum Nigrum Pianomide and preparation method thereof.
Background technology
Middle East respiration syndrome (MERS) is the viral respiratory disease caused by a kind of novel coronavirus (MERS-CoV), this virus was found in 2012 first in Saudi Arabia, coronavirus is one group of virus that human and animal can be caused to fall ill, and often causes the mankind that the various diseases of from common cold to severe acute respiratory syndrome (SARS) occurs.Middle East respiration syndrome symptom: model case often presents heating, the symptom such as cough and breathe hard, and often finds pneumonic in inspection.Gastrointestinal symptom, as diarrhoea etc. also has report.Severe cases can cause respiratory failure, needs in the indoor mechanical ventilation of Intensive Care Therapy and Supporting Therapy.Can there is organ failure in some cases, especially renal failure and septic shock, and case fatality rate is about 27%-40%.In 25, on Mays of bulletin of the World Health Organization in JIUYUE, 2012 to 2015, the whole world has 24 countries accumulative report Middle East respiration syndrome confirmed cases 1139 example, and wherein 431 people are dead.Middle East respiration syndrome is that novel coronavirus infects acute, the Serious respiratory tract disease that cause, there is no available vaccine and medicine at present.This virus causes the crowd of hypoimmunity, old people and more serious disease occurs with chronic disease (as diabetes, cancer and chronic lung disease) crowd.Domestic the first Introduced cases MERS patient was made a definite diagnosis in Guangdong Huizhou and was isolated on May 29th, 2015, caused the world of medicine of China to show great attention to.In the world today in the face of Middle East respiration syndrome (MERS) is stymied by the moment, application natural drug is antibacterial, antiviral, antiinflammatory, immunity moderation etc. will make Chinese medicine ethnic drug again glisten, for the mankind make major contribution in the sick field of global prevalence.
Chinese medicine is natural materials, and maintain naturality and the biological activity of various composition, its composition is easily absorbed and used, and unabsorbablely also can excrete smoothly, in vitro by decomposition such as antibacterials, and can not contaminant water environment.Even if poisonous Chinese herbal medicine is after suitable Preparation process, toxicity can reduce or disappear, and general chemicals becomes branch to be accumulated in animal body or extended residual in water.Utilize the interaction between Chinese medicine, make after prescription compatibility, improve its effect of preventing and curing diseases, and weaken or eliminate toxic and side effects.
Chinese medicine ethnic drug should be played a positive role in upper respiratory tract and intestinal infection treatment.Upper respiratory tract infection is acute inflammation general name between nasal cavity to throat, is most Common infectious diseases.About 90% is caused by virus, after bacteriological infection is often secondary to viral infection.These disease four seasons, any age all can fall ill, and by containing the viral spittle, droplet, or propagate through polluting apparatus.Normal when Abwehrkraft des Koepers is low, as caught cold, tired, drench with rain, former existed or extraneously invaded virus or antibacterial, ramp is bred, cause infecting, Chang Jifa bronchitis, pneumonia, nasal sinusitis, a few peoples' complicated with acute myocarditis, nephritis, rheumatic fever etc.Within less than 6 years old, child is due to immune system undeveloped mature, and resistance is poor, and clinical symptoms performance is heavier, if give effective treatment not in time, easily leads to complications.Finding a kind of effectively Therapeutic Method is the clinical research most important thing.Current doctor trained in Western medicine lacks effective ways to the antiviral therapy that children's acute is felt, therefore therapy of combining Chinese and Western medicine method obtains the attention of more and more Pediatric Clinic researcher.Hand-foot-mouth disease is a kind of enterovirus infection disease, and Clinical symptoms occurs phlysis based on hands, foot, oral cavity, and often accompanies by the phenomenons such as projection heating, sialorrhea, refusing to eat, is mainly in infant, easily shows summer and autumn.
Existing treatment infect and inflammation mostly be the Western medicine such as hormone, antibiotic chemicals, hormone is as prednisone, cortisone etc., antibiotic is as penicillins, cephalosporins, Macrolide, aminoglycoside, Tetracyclines, chloromycetin, quinolones, sulfonamides etc., these medicines have certain curative effect to infection and inflammation, but easily produce drug resistance, toxic and side effects is larger, damage the functions such as the heart, liver, kidney, nervous system in various degree, Immunosuppression function, break colony balance or metabolic balance in body, and relapse rate is higher.But Chinese medicine still is apparent not enough in infection inflammatory applications, and clinically to depend on unduly and the Western medicine chemicalses such as abuse of antibiotics.
In the present invention, main Chinese medicinal materials overview is as follows:
Herba Solani Nigri is the dry herb of plant of Solanaceae Herba Solani Nigri (SolanumnigrumLinn.) or S. photeinocarpum (S.photeinocarpumNakamuraetOdashima.), be used as medicine for good with dry, green, the fertile tender person of color, Guangxi is among the people often to be done vegetable with S. photeinocarpum tender leaf and eats, call bitter certain herbaceous plants with big flowers, Herba Solani Surattensis, night sky, sky bubble fruit, wild Fructus Capsici, black Fructus Solani melongenae, Radix vitis romanetii etc., all there is distribution all parts of the country, are widely distributed in Europe, Asia, temperate zone, America to torrid areas.Herba Solani Nigri is long at China's applicating history, and Tang's " property of medicine opinion ", Tang's " Newly Revised Canon of Materia Medica ", bright Compendium of Material Medica, " the southern regions of the Yunnan Province book on Chinese herbal medicine ", " Guizhou medical herbs " etc. record.Herb of Herba Solani Nigri and fruit thereof contain alkaloid, polysaccharide and other multiple active components, as: solanine (Solanine), solasonine (Solsonine), solasonine (Solaonine), solamargine (Solamargine), 13-solamargine (13-Solamargine), glycoalkaloid (Glycoalkaloid) etc., aglycon after solasonine and solamargine are hydrolyzed is solasodine (solasodine), and alkaloid is maximum with immature fruit.Herba Solani Nigri bitter in the mouth, micro-sweet, cold, slightly poisonous, return lung, stomach, urinary bladder channel, have heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, the effects such as dispersing swelling and dissipating binds, antiinflammatory diuresis.
Ramulus Et Folium Pithecellobii Lucidi (Pithecellobiumclypeariabenth.) is Dicotyledoneae Mimosoideae plant, perennial this plant of Qiao, the mother-in-law of crying among the people split tree, bib tree, Cor Gigeriae Galli tree, three not just, wooden pail for urine public, hair washing tree, Habenaria aitchisonii etc., be distributed in south China Guangdong, Guangxi and Zhejiang, Fujian, Taiwan, Sichuan, Yunnan, Burma, Indonesia etc., folk tradition washes skin ulcer and suppurative wound, eczema etc. so that Ramulus Et Folium Pithecellobii Lucidi branch and leaf are to boil water, effect of removing the rotten and letting fresh grow uniqueness.Compendium of Material Medica, " register planted by Guangxi medicine " etc. are recorded.In July, 1984 by south China Institute of Zoology classify room differentiate that former plant is Mimosaceae, after by WHO be grouped into pulse family Ramulus Et Folium Pithecellobii Lucidi belong to.Ramulus Et Folium Pithecellobii Lucidi browse includes the effective ingredient such as special sharp yellow skin (penta hydroxy group flavane), myricetrin, Quercitroside, Quercetin, gallicin and gallic acid.Ramulus Et Folium Pithecellobii Lucidi nature and flavor bitterness is cold, and returning lung, stomach, large intestine channel, effect heat-clearing and toxic substances removing, removing dampness sore, is the southern medical material for the treatment of multiple pyretic toxicity disease uniqueness, has the splendid curative effect that heat-clearing and toxic substances removing, removing heat from blood are subsided a swelling, removed the rotten and let fresh grow; Ramulus Et Folium Pithecellobii Lucidi clearing away heat-fire, detoxifying, removing dampness, both gone up the fire-toxin of moistening and cleaning throat, lung, and lower clear large intestine is damp and hot, clinical in laryngopharynx swelling and pain again, comprises pharyngolaryngitis, acute tonsillitis; Cough due to lung-heat, comprise upper respiratory tract infection, pneumonia; And damp and hotly to rush down, comprise acute enteritis, dysentery etc.
The dry herb that Herba Hydrocotyles (HydrocotylesibthorpioidesLam.) is samphire Herba Hydrocotyles is Guangxi Zhuang, precious jade, Dong, the Mulao commonly use traditional herbal medicine.Plant has peat-reek, and climing bud-leaf can be stir-fried and eaten or boil soup, as the wild Herba Coriandri of the green type of nuisanceless health care.The Tang Dynasty Sun Simiao Prescriptions Worth Thousand Gold for Emergencies, " Guangxi Chinese crude drug standard " etc. are recorded, containing flavonoid glycoside, Quercetin, kaempferol, aminoacid, volatile oil, coumarin etc., Herba Hydrocotyles mildly bitter flavor, sweet, pungent, cool in nature, enter liver, kidney, lung meridian, there are heat-clearing and toxic substances removing, dampness removing jaundice eliminating, cough-relieving, dispersing swelling and dissipating binds effect, are used for the treatment of icterohepatitis, infantile hyperpyrexia, gonorrhea, herpes zoster, laryngopharynx swelling and pain etc.
Still lack 3 taste Special Traditional Chinese Medicine ethnic drug compatibility investigation and application and preparations at present.
For meeting clinical needs and solving above-mentioned Problems existing, it is obvious that we research and develop the effect of a kind of antiviral antimicrobial antiphlogistic, the herbal mixture that toxic and side effects is less, and in conjunction with modern study achievement, use the preparation of Modern preparations advanced technologies and Quality Control technology, traditional decoction method loaded down with trivial details for Chinese medicine is transformed into compact and is easy to carry, steady quality, dosage is accurate, and the Chinese medicine tablet conveniently taken.
Summary of the invention
For meeting clinical needs and solving above-mentioned Problems existing, the invention provides the effect of a kind of antiviral antimicrobial antiphlogistic obvious, toxic and side effects is little, the Compound Solanum Nigrum Pianomide of taking convenience.
Described Pianomide is made primarily of the raw material of following parts by weight: Herba Solani Nigri 500 ~ 3000 parts, Herba Hydrocotyles 500 ~ 3000 parts, Ramulus Et Folium Pithecellobii Lucidi 500 ~ 3000 parts.
Preferably, described Pianomide is made primarily of the raw material of following parts by weight: Herba Solani Nigri 500 ~ 1000 parts, Herba Hydrocotyles 500 ~ 1000 parts, Ramulus Et Folium Pithecellobii Lucidi 500 ~ 1000 parts.
Preferably, described Pianomide is made primarily of the raw material of following parts by weight: Herba Solani Nigri 1000 ~ 2000 parts, Herba Hydrocotyles 1000 ~ 2000 parts, Ramulus Et Folium Pithecellobii Lucidi 1000 ~ 2000 parts.
Preferably, described Pianomide is made primarily of the raw material of following parts by weight: Herba Solani Nigri 2000 ~ 3000 parts, Herba Hydrocotyles 2000 ~ 3000 parts, Ramulus Et Folium Pithecellobii Lucidi 2000 ~ 3000 parts.
Preferably, described Pianomide also comprises: starch 0.5 ~ 5 part, carboxymethyl starch sodium 0.5 ~ 5 part, magnesium stearate 0.1 ~ 1 part.
Preferably, described starch can also be replaced by one or several following raw materials: polyvidone, octadecanol, hexadecanol, stearic acid, citric acid, microcrystalline Cellulose, dextrin, lactose, mannitol, sodium bicarbonate, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose (L-HPC), crospolyvinylpyrrolidone, magnesium stearate, Pulvis Talci, micropowder silica gel.
Described Pianomide effect: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, expelling phlegm for arresting cough, diuretic antidiarrheal etc.
Described Pianomide cures mainly: upper respiratory tract infection, acute pharyngolaryngitis, acute tonsillitis, infantile common cold fever, cough due to lung-heat, senile chronic tracheitis, bronchial asthma, acute gastroenteritis, hepatitis, jaundice, dysentery, leukorrhagia, gynecological inflammation, dysuria, gonorrhea, prostatitis, acute nephritis and furuncle sore and toxic, dermatitis and eczema, osteopatia sprain etc.In addition, the present invention also can be used for preventing and treating the epidemic disease such as respiratory infectious disease, infectious intestinal disease that viral germina infection causes, also can be used for treatment Middle East respiration syndrome, hand foot and mouth disease, urinary system infection, hepatocarcinoma, gastric cancer, esophageal carcinoma, bladder cancer etc.
Using method: oral, 1 ~ 3 time on the one, each 2 ~ 4.Children taking decrement is also followed the doctor's advice.
Points for attention: weakness of the spleen and stomach, the deficiency of vital energy or yang-deficiency constitution person avoid clothes, the careful clothes of anemia of pregnant woman.
Effect duration: 2 years.
The present invention has the following advantages:
One, Pianomide of the present invention is Chinese medical theory prescription traditionally, and Herba Solani Nigri is the monarch drug of our heat-clearing and toxic substances removing, and Ramulus Et Folium Pithecellobii Lucidi is ministerial drug, and Herba Hydrocotyles is that many duties appointed by a medicine, bears adjuvant.Herba Solani Nigri, Ramulus Et Folium Pithecellobii Lucidi and Herba Hydrocotyles all can heat-clearing and toxic substances removing etc., and difference is that Herba Solani Nigri is apt to inducing diuresis to remove edema, improves immunity; Under Ramulus Et Folium Pithecellobii Lucidi is kind, clear large intestine is damp and hot; Herba Hydrocotyles is apt to the jaundice of clear dampness-heat in the liver and gallbladder, and lower clearing away damp-heat pents up the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, kidney or vesical calculus, dysuria, even twinge hematuria person.Three's compatibility plays the merit of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, expelling phlegm for arresting cough, diuretic antidiarrheal altogether.They are two years old, Pianomide of the present invention is broad spectrum antibiotic and antiviral agents, to pathogenic bacterium and the conditioned pathogen of respiratory tract, digestive tract and urethra, comprise staphylococcus aureus, first streptococcus, second streptococcus, Bacillus proteus, escherichia coli, Bacillus typhi, dysentery bacterium (Shigella), bacillus pyocyaneus, hog cholera bacillus, Candida albicans etc. and have comparatively high inhibition effect, avoid western medicine antibiotics abuse and depend on the bacterial resistance, deafness, darling renal function infringement etc. that cause unduly, be applicable to children.Middle East MERS-CoV coronavirus and SARS virus belong to coronavirus together, and case fatality rate is but higher than SARS.The present invention has anti-various respiratory road virus and hepatitis B virus effect, also may be effective to Middle East coronavirus, and inflammation-inhibiting cellular infiltration, the release action of prevention inflammatory factor, prevent pernicious pathology to circulate, alleviate organ-tissue damage, maintain normal physiological function.The present invention strengthens antibacterial, antiviral, antiphlogistic effects, and improve immunity, diuresis antidiarrheal, cures mainly infection and the inflammation such as body surface, respiratory system, digestive system, urinary system.They are three years old, Pianomide of the present invention contains the effective ingredient such as solasonine, solamargine, gallic acid, Quercetin, kaempferol, wherein solasonine reduces the activity of vascular permeability and hyaluronidase, some protective effect is had to anaphylaxis, burn property, histamine shock, but it is different from cortisone, solasonine does not suppress antibody tormation, has facilitation on the contrary; Herba Solani Nigri extract suppresses staphylococcus aureus, dysentery bacterium, fungus etc.; Herba Solani Nigri polysaccharide suppresses hepatitis B virus; Rhizoma Kaempferiae have the effects such as antibacterial, antiinflammatory, antioxidation, antiulcer, spasmolytic, function of gallbladder promoting diuresis, eliminating phlegm and stopping cough and enhancing immunity; Gallic acid has antibacterial, antiviral, antiinflammatory, antitumor, antiallergic, choleretic and bronchiectasis, can be used as astringent and hemorrhage; Quercetin remarkable Inhibitory promotion cancer agent effect, suppress in vitro Malignant cellular growth, suppress ehrlich ascites cell DNA, RNA and protein synthesis.Have eliminate the phlegm preferably, antitussive action, and have certain antiasthmatic effect.In addition reduce blood pressure in addition, strengthen capillary resistance, reduce capillary fragility, blood fat reducing, coronary artery dilator, increase the effects such as coronary flow.Be used for the treatment of chronic bronchitis.Also auxiliary therapeutic action is had to coronary heart disease and hyperpietic.Cortex querci dentatae have the release action of anticoagulant and 5-hydroxy tryptamine (5-HT).Quercetin all has obvious inhibitory action to the platelet aggregation that ADP, thrombin and platelet activating factor (PAF) are induced, wherein the strongest to the inhibitory action of PAF, and Quercetin also can the rabbit platelet 3H-5-HT of obvious enzyme induction anticoagulant discharge.Its four, the present invention adopts modern advanced technologies, and starch is in the present invention as diluent and binding agent, and the content of active component of dilution unit volume, fills the weight or volume of tablet, so that preparations shaping and divided dose, thus be convenient to tabletting.Meanwhile, extract powder itself does not have viscosity or viscosity is less, adds starch and it can be made to be glued together.Carboxymethyl starch sodium has stronger water absorption and dilatancy, comparatively fast can steep and rise in cold water, and grain expansion and not dissolving after water suction, do not form colloid solution, do not hinder the continuation of moisture to infiltrate and affect the further disintegrate of tablet, as superdisintegrantes.Magnesium stearate is mainly used as lubricant, antiplastering aid, fluidizer, makes the granule made have good mobility and compressibility.
In a word, the present invention utilizes Chinese medicine characteristic, in conjunction with modern study achievement, Herba Solani Nigri, Ramulus Et Folium Pithecellobii Lucidi and Herba Hydrocotyles and many effective ingredient thereof are made full use of, play Mutiple Targets synergistic mechanism effect, strengthen antibacterial, antiviral, antiphlogistic effects, improve immunity etc., and overcome folk prescription limitation and reduce toxic and side effects, make the present invention have the effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, expelling phlegm for arresting cough, diuretic antidiarrheal.The present invention utilizes China's Special Traditional Chinese Medicine ethnodrug resources advantage, cohesion elite, the advanced environmental protection of technique, quality controllable stable, definite ingredients, dosage is accurate, curative effect is obvious, act on stronger, sphere of action is wider, and avoid the Western medicine abuses such as hormone antibiotic and rely on the bacterial resistance caused, deaf, darling renal function infringement etc., be transformed into can be directly swallowed by loaded down with trivial details traditional decoction method simultaneously, chew containing to suck or by the form taken after aqueous dispersion, be applicable to many people's medication, the present invention is fully demonstrated and plays Chinese medicine ethnic drug in treatment respiratory tract infection, the infection of the complexity such as urinary tract infection and intestinal infection and the important function in the sick field of global prevalence.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
Embodiment 1
The concrete preparation process of the technical program is as follows:
1) to Herba Solani Nigri, Herba Hydrocotyles and Ramulus Et Folium Pithecellobii Lucidi carry out cleaning respectively, dry, are ground into coarse powder subsequently respectively for subsequent use;
2) in the Herba Solani Nigri coarse powder of 1000g, add the ethanol of 70%, ethanol weight is 10 ~ 20 times of coarse powder, i.e. 10kg ~ 20kg, and the temperature range reflux 2 times of 70 ~ 80 DEG C, each return time is 1h, is filtered by gained extracting solution.In medicinal residues, add 10 ~ 20 times of water, i.e. 10kg ~ 20kg of coarse powder weight, extract 2 times, each 1h, gained extracting solution filters.Merge gained extracting solution, also concentrated through 60 ~ 70 DEG C of decompression recycling ethanols, spraying dry obtains extract powder A.
3) in the Herba Hydrocotyles coarse powder of 1000g, add the ethanol of 70%, ethanol weight is 10 ~ 20 times of coarse powder, i.e. 10kg ~ 20kg, and the temperature range reflux 2 times of 70 ~ 80 DEG C, each return time is 1h, is filtered by gained extracting solution.In medicinal residues, add 10 ~ 20 times of water, i.e. 10kg ~ 20kg of coarse powder weight, extract 2 times, each 1h, gained extracting solution filters.Merge gained extracting solution, also concentrated through 60 ~ 70 DEG C of decompression recycling ethanols, spraying dry obtains extract powder B.
4) in the Herba Solani Nigri coarse powder of 1000g, add the ethanol of 70%, ethanol weight is 10 ~ 20 times of coarse powder, i.e. 10kg ~ 20kg, and the temperature range reflux 2 times of 70 ~ 80 DEG C, each return time is 1h, is filtered by gained extracting solution.In medicinal residues, add 10 ~ 20 times of water, i.e. 10kg ~ 20kg of coarse powder weight, extract 2 times, each 1h, gained extracting solution filters.Merge gained extracting solution, also concentrated through 60 ~ 70 DEG C of decompression recycling ethanols, spraying dry obtains extract powder C.
5) by extract powder A, B, C and starch 3g, carboxymethyl starch sodium 3g, magnesium stearate 1g mixing granulation, subsequently that granule is compressing, film coating, qualified through quality inspection, subpackage, packs and get final product.
Embodiment 2
The concrete preparation process of the technical program is as follows:
1) to Herba Solani Nigri, Herba Hydrocotyles and Ramulus Et Folium Pithecellobii Lucidi carry out cleaning respectively, dry, are ground into coarse powder subsequently respectively for subsequent use;
2) each 1000g mixing of Herba Solani Nigri, Herba Hydrocotyles and Ramulus Et Folium Pithecellobii Lucidi coarse powder is taken, the ethanol of 70% is added in the coarse powder of mixing, ethanol weight is 10 ~ 20 times of coarse powder, i.e. 30kg ~ 60kg, the temperature range reflux 2 times of 70 ~ 80 DEG C, each return time is 1h, is filtered by gained extracting solution.In medicinal residues, add 10 ~ 20 times of water, i.e. 30kg ~ 60kg of coarse powder weight, extract 2 times, each 1h, gained extracting solution filters.Merge gained extracting solution, also concentrated through 60 ~ 70 DEG C of decompression recycling ethanols, spraying dry obtains extract powder.
3) by extract powder and and starch 3g, carboxymethyl starch sodium 3g, magnesium stearate 1g mixing granulation mixing granulation;
4) granule is compressing, film coating, qualified through quality inspection, subpackage, packs and get final product.
Embodiment 3
1) to Herba Solani Nigri, Herba Hydrocotyles and Ramulus Et Folium Pithecellobii Lucidi carry out cleaning respectively, dry, are ground into coarse powder subsequently respectively for subsequent use;
2) Herba Solani Nigri, Ramulus Et Folium Pithecellobii Lucidi, each 1000g mixing of the dry medicinal material coarse powder of Herba Hydrocotyles is got, 10 ~ 20 times of 50% ethanol is added in the coarse powder of mixing, supersound extraction 1 ~ 3 time, filter, filtrate is through salting out method or acid-base method or ultrafiltration technology or adsorbing material process, use water and graded ethanol solutions eluting successively again, collect required treatment fluid or eluent, be drying to obtain required extract powder.
3) by extract powder and starch 3g, carboxymethyl starch sodium 3g, magnesium stearate 1g mixing granulation;
4) granule is compressing, film coating, qualified through quality inspection, subpackage, packs and get final product.
Embodiment 4
Get the extract obtained powder of above-described embodiment 1,2 or 3, can add vitamin C, dextrin, xylitol, stevioside, Herba Menthae wet goods flavoring agent, mixing dry granulation, tabletting, makes Compound Solanum Nigrum anti-inflammatory lozenge.
Conventional flavoring agent, except vitamin C, xylitol, stevioside, Oleum menthae, also has protein sugar, glycerol, sorbitol, mannitol, synthetic sweetener saccharin sodium, spice etc.Natural perfume material has the aromatic volatile material extracted from plant, as Fructus Citri Limoniae, Fructus Foeniculi, Herba Menthae wet goods, and aromatic water, tincture, spirit etc. that this type of volatile material is made; Artificial perfume, also known as essence, is in artificial flavors, add the allotment of appropriate solvent form, as apple essence, flavoring orange essence, flavoring banana essence etc.
Usual excipients, except starch, also has one or more in polyvidone, octadecanol, hexadecanol, stearic acid, citric acid, microcrystalline Cellulose, dextrin, lactose, mannitol, sodium bicarbonate, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose (L-HPC), crospolyvinylpyrrolidone, magnesium stearate, Pulvis Talci or micropowder silica gel etc.
Embodiment 5
The ratio of the extract obtained powder of above-described embodiment 1,2 or 3 and cyclodextrin 1: 1 carries out enclose: first make cyclodextrin water saturation solution, then mixed powder is added, be fully ground to into pastel, cold drying, obtain cyclodextrin clathrate.Be framework material with HPMC and acrylic resin, add PVP and make binding agent, after mixing with cyclodextrin clathrate, make soft material.By soft material cold drying, pulverize to obtain fine powder, then get fine powder and add starch as diluent, with 95% ethanol for wetting agent is granulated, cold drying, granulate, finally adds magnesium stearate as lubricant, and tab weighs and pressure, tabletting, make 200, qualified through quality inspection, obtain Compound Solanum Nigrum antiinflammatory slow release long-acting tablet.Its extended durations of action is to 3 ~ 5 times of Compound Solanum Nigrum antiinflammatory conventional tablet.
Above-mentioned framework material is one or more in hydroxypropyl emthylcellulose, propenoic acid resin series, carboxymethyl cellulose and ethyl cellulose etc.The component of slow releasing preparation and weight percent content are:
Extract powder 10 ~ 50%, framework material 10 ~ 60%, diluent 15 ~ 70%, lubricant 0.1 ~ 1%, the weight percent content summation of each component is 100%.
Embodiment 6
The ribavirin that the Compound Solanum Nigrum Pianomide adopting above-described embodiment 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 to develop and Dalian Deze Pharmaceutical Co., Ltd produce carries out resisiting influenza virus contrast test.
SPF level Kunming mouse is selected to carry out animal experiment.Mice weighs 18 ~ 22g, male and female half and half, is provided by Guangxi Medical University's Experimental Animal Center, animal productiong credit number: osmanthus SCXK2009-0002, animal occupancy permit number: osmanthus SCXK2009-0004.
Select Strain and cell: select the A1 type influenza A virus provided by Guangxi District disease prevention and control center, virus inoculates the allantoic cavity of instar chicken embryo on the 9th ~ 11 routinely, 35 DEG C hatch 72h after collect allantoic fluid, measure hemagglutination activity, the allantoic fluid subpackage that Hemagglutination titer is greater than 128, puts-80 DEG C of Refrigerator stores stand-by.Purchased from the mdck cell strain of Zhongshan University's Experimental Animal Center Cytology Lab, cell culture fluid is containing the penicillin of 100U/mL, the streptomycin of 100 μ g/mL and the DMEM culture fluid of 10% hyclone; For diluting the maintenance medium of medicine 1. containing the DMEM of 2% hyclone, other same growth-promoting medias; For maintenance medium during Influenza Assay 2. not containing hyclone, containing the same culture fluid of other compositions of DMEM of 2 μ g/mL pancreatin.
Virus virulence measures: 2. viral suspension maintenance medium being done 10 times of dilutions is 1 × 10
-1~ 10
-8totally 8 dilution factors, add mdck cell and grown up in 96 orifice plates of monolayer, each dilution factor inoculates 4 holes, every hole 100 μ L, 35 DEG C, 5%CO
2in hatch 2h, abandon virus liquid, last 1 secondary control dry doubling adds 100 μ L maintenance mediums 2, establish normal cell controls group, inverted microscope observation of cell lower every day pathological changes, the method mensuration red cell agglutination that in culture fluid, hemagglutination activity (HA) is set up by national influenza center is tired: get 25 μ L culture fluid from each hole of test simultaneously, add in 96 orifice plates, add the 1% guinea-pig red blood cell suspension that 25 μ L prepare, at mixing rearmounted 4 DEG C mutually, constant temperature leaves standstill 30 ~ 60min, observes HA.Calculate median infective dose (TCID
50).Reed-muench method is adopted to calculate the TCID of influenza virus A 1 in mdck cell
50be 10
-4, in test, virus attack amount is 100TCID
50, show that the influenza virus virulence selected is strong.
Drug toxicity measures: 1. the medicinal liquid make the Compound Solanum Nigrum Pianomide that embodiment 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 are developed and positive control drug ribavirin maintenance medium do 2 times of dilutions, add and grow up in 96 holes of cell monolayer, establish blank group simultaneously, each mass concentration medicinal liquid is added in Tissue Culture Plate, each concentration 4 hole, every hole 100 μ L.In 37 DEG C, 5%CO
23 ~ 5d is cultivated, observation of cell form under inverted microscope in incubator.Calculate maximal non-toxic concentration (TC
0).
The Compound Solanum Nigrum Pianomide that embodiment 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 are developed and positive drug ribavirin are all with TC
0do Antiviral Effect test, draw each medicine maximal non-toxic concentration TC according to cytopathy
0, in table 1.In comparison sheet 1 Compound Solanum Nigrum Pianomide and ribavirin medicine maximal non-toxic concentration known, the toxicity of the Compound Solanum Nigrum Pianomide that embodiment 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 are developed is all lower.
Table 1 medicine maximal non-toxic concentration (TC
0)
The inhibitory action (mtt assay) of medicine infected by influenza: with maintenance medium 2. diluted concentration be 100TCID
50influenza virus, adds and grows up in 96 holes of cell monolayer, every hole 100 μ L, in 35 DEG C, and 5%CO
2adsorb 1.5h infection cell in incubator, abandon virus liquid, control is dry.Each medicine is all diluted to maximal non-toxic concentration by maintenance medium, is added by each medicine in the cell plates infected, each concentration 4 hole, and every hole 100 μ L, establishes blank group, virus control group, ribavirin group simultaneously.In 37 DEG C, 5%CO
2in hatch 24h.Discarded by culture fluid in plate, control is dry, adds maintenance medium, 100 μ L/ holes, observation of cell pathological changes.When virus control wells occur at utmost pathological changes time, add the every hole 20 μ L of MTT (5g/L), 37 DEG C, 5%CO
2in hatch 5h.Discarded by culture fluid in cell plates, control is dry, adds DMSO150 μ L/ hole, vibration, effect 10min.Microplate reader 570nm surveys A value, and blank well returns to zero.Calculate suppression ratio.
More all there were significant differences (P < 0.05 or P < 0.01), in table 2 with blank group and virus control group under same medicine condition for the Compound Solanum Nigrum Pianomide that embodiment 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 are developed and ribavirin.
The inhibitory action (x ± s, n=4) of table 2 pair A1 influenza virus
This experimentation shows: the Compound Solanum Nigrum Pianomide cytopathy that infected by influenza causes in vitro that embodiment 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 are developed all has obvious inhibitory action.To A1 influenza virus, after the administration of Compound Solanum Nigrum Pianomide cell survival amount comparatively virus control group be all significantly increased, the large quantitative change circle of cellular morphology of virus control group, merge, downright bad, come off, and the cellular morphology of Compound Solanum Nigrum Pianomide group is close to normal group cell, assume diamond in shape or polygon, sharpness of border, its suppression ratio is higher than ribavirin matched group.
Embodiment 7
The clinical observation on the therapeutic effect of Compound Solanum Nigrum Pianomide treatment upper respiratory tract infection.
Select 85 routine upper respiratory tract infection (wind-heat syndrome) patients, all go to a doctor in morbidity 4 ~ 48h, all except fit on other drug therapist, merge coronary heart disease, hypertension, cerebrovascular and lung, liver, kidney, disease of hematopoietic system person, psychotic, gestation or women breast-feeding their children and drug allergy person.Random point two groups: treatment group 55 example, man 30 example, female 25 example; 15 ~ 40 years old 26 age example, 40 ~ 60 years old 24 example, 60 ~ 75 years old 5 example; The heat that occurs together 35 example, headache 30 example, watery nasal discharge 39 example, cough 30 example, pharyngalgia 45 example, antiadoncus 22 example, white and thin fur 45 example, floating and rapid pulse 53 example; Matched group 30 example, man 14 example, female 16 example; 15 ~ 40 years old 12 age example, 40 ~ 60 years old 16 example, 60 ~ 75 years old 2 example; The heat that occurs together 15 example, headache 12 example, watery nasal discharge 24 example, cough 15 example, pharyngalgia 25 example, antiadoncus 10 example, white and thin fur 27 example, floating and rapid pulse 27 example.Two groups of patients have comparability.
According to diagnostic criteria diagnosis of catching a cold in Acute viral upper respiratory infection in " internal disease diagnostic criteria and medical record ": 1. 15 years old≤age≤75 years old; 2. generate heat, axil temperature >=37.5 DEG C but≤39 DEG C; 3. Leukocyte Counts is arm's length standard or minimizing, and neutrophil ratio is normal or reduce; 4. Acute onset, sneeze, nasal obstruction, watery nasal discharge, have itching throat pharyngalgia; 5. hoarseness or have cough; 6. pharyngeal congestion or have secretions, or have lymph foilicie hyperplasia, antiadoncus; 7. headache, articular muscle are ached.It is 1. 2. 3. 4. wherein essential condition.With reference to pertinent regulations in " Chinese medical disease Standardization of diagnosis and curative effect ": 1. local symptom has sneeze, nasal obstruction, watery nasal discharge, cough, dry pharynx pharyngalgia, and tonsillitis is swollen and ache; 2. General Symptoms has heating, aversion to wind, hypohidrosis, headache, mouth micro-thirsty, tongue tip side of red, white and thin fur, floating and rapid pulse.
It is oral that treatment group gives Compound Solanum Nigrum Pianomide, 2 ~ 4 pieces/times, 3 times/d; Matched group is oral gives fu fang gan mao ling tablets, 4 pieces/times, 3 times/d.Two groups is all 1 course for the treatment of with 3d.
Observe the signs such as disease and pharyngeal mucosa, lymph node, tonsil such as patient heating, aversion to wind, sneeze, headache, cough, pharyngalgia, picture of the tongue, pulse condition, body temperature self testing and every day 2 records.
Efficacy assessment standard.Recovery from illness: 3d endosome temperature drop is to normal, and symptom, sign recover normal; Effective: 3d endosome temperature drop is to normal, and symptom, sign obviously alleviate; Effective: 3d endosome temperature drop is low 2 DEG C, and symptom, sign alleviate; Invalid: the medication 3d state of an illness is without improvement or increase the weight of.
The curative effect of the heating for the treatment of group and matched group, headache, cough, pharyngalgia, antiadoncus is as shown in table 3, and the curative effect of its curative effect upper respiratory tract infection is as shown in table 4.
Table 3 generates heat, have a headache, the curative effect of pharyngalgia and antiadoncus
Note: treatment group compares with matched group, P < 0.05.
Table 4 upper respiratory tract infection curative effect
Note: compare with matched group, * P < 0.01.
Acute upper respiratory tract infection is the common disease of clinical emergency and outpatient service, and the four seasons all have, especially occurred frequently spring autumn and winter; normal Acute onset; show as nasal obstruction watery nasal discharge, itching throat or pain, cough and expectoration, headache or muscular soreness of whole body, often with heating, Leukocyte Counts is normal or reduce.As shown in Table 3, the upper sense of Compound Solanum Nigrum Pianomide treatment (wind-heat syndrome) total effective rate is apparently higher than matched group and comparatively fast eliminate the symptoms such as heating, headache, pharyngalgia, Shorten the Treatment Process, and taking convenience, safe and effective, provide another effective way for clinical treatment being felt (wind-heat syndrome).As shown in Table 4, the total effective rate taking the treatment group of Compound Solanum Nigrum Pianomide is significantly higher than the matched group taking fu fang gan mao ling tablets, shows evident in efficacy to upper respiratory tract infection of Compound Solanum Nigrum Pianomide thus.
Embodiment 8
The routine clinical observation on the therapeutic effect of Compound Solanum Nigrum Pianomide treatment acute gastroenteritis 60.
In June, 2013 ~ 2014 accept patient's totally 102 examples meeting acute gastroenteritis diagnostic criteria for medical treatment, wherein male 60 example, women 42 example year June, 20 ~ 70 years old age, morbidity is 1 ~ 3d, and conventional blood bio-chemistry checking, without hepatic and kidney function obstacle, is divided into treatment group and matched group at random.Treatment group 60 example, male 38 example, women 22 example; Matched group 42 example, male 22 example, women 20 example.Two groups of sexes, age, coincident with severity degree of condition no significant difference (P > 0.05).
Matched group adopts doctor trained in Western medicine customary medical treatment, comprises the treatment of general treatement, symptomatic therapy and cause of disease.Patient lies up, warming, fasting 12h, later a small amount of liquid diet gradually, slowly recovers normal diet, suitable pain-alleviating diarrhea-relieving, oral person can give oresol, when vomiting maybe can not be taken in, give venous transfusion, maintain soda acid and water-electrolyte balance, do drug sensitive test while coproculture pathogenic bacterium, instruct rational use of drug.Treatment group adds on western medicine routine treatment basis uses Compound Solanum Nigrum Pianomide, every day 3 times, 2 ~ 4/ times, the course for the treatment of 3 ~ 5d.
Curative effect determinate standard.Effective: sings and symptoms disappears completely, stool microscopy is normal; Effective: the state of an illness is clearly better, but have light symptoms, stool microscopy leukocyte count reduces; Invalid: after medication 5d, the state of an illness is without taking a turn for the better or increasing the weight of to some extent.
Comparison therapy group and the matched group clinical efficacy of acute gastroenteritis are as shown in table 5.As shown in Table 5, the effective percentage for the treatment of group to treatment acute gastroenteritis is significantly higher than the effective percentage of matched group, shows thus, and Compound Solanum Nigrum Pianomide has significant effect to treatment acute gastroenteritis.
Table 5 acute gastroenteritis curative effect
Note: compare with matched group, * P < 0.05.
Change without exception after untoward reaction two groups of patient's hepatic and renal functions, routine blood test, PLT treatment, and after medication two groups all there is not irritated grade for untoward reaction, show that Compound Solanum Nigrum Pianomide treatment acute gastroenteritis is to the Liver and kidney not damaged of human body, safety of medicine is reliable.
Embodiment 9
The routine clinical observation on the therapeutic effect of Compound Solanum Nigrum Pianomide treatment urinary system infection 30.
Use Compound Solanum Nigrum Pianomide treatment urinary system infection 30 example, wherein man 12 example, female 18 example, 14 ~ 60 years old age, acute urinary system infects 22 examples, the course of disease 6 ~ 30 days, average 15 days, Chronic urinary infection is acute attack 8 example repeatedly, disease time 1 ~ 6 year, average 2.5 years.The equal frequent micturition of this group case, urgent micturition, dysurea, not to the utmost, 24 examples are with lumbago, and 26 examples are generated heat with fear of cold, and body temperature is at 38 ~ 39.5 DEG C for dribbling urination.Lab testing: 27 routine total white blood cellses 1 ~ 20,000, neutral 75 ~ 90%.Red in all cases routine urinalysis, leukocyte and pus cell+~ ++++, rarely a small amount of granular cast or white cell cast.Have 24 examples to make urine before medication to cultivate, wherein 17 examples turn out escherichia coli.16 examples are had once to use the Drug therapys such as norfloxacin.Instructions about how to take medicine: each 3, every day 3 times 5 days was 1 course for the treatment of.
This group case when taking this medicine without exception stop using other medicines.After treatment frequent micturition, urgent micturition, dysurea and dribbling urination not to the utmost etc. symptom all disappear, body temperature is normal, and routine urinalysis the moon turns, and wherein 21 examples took for 2 courses for the treatment of, and 4 examples took for 3 courses for the treatment of, and 3 examples took for 4 courses for the treatment of, and 2 examples took for 6 courses for the treatment of.8 routine Chronic urinary infections are through following up a case by regular visits to 4 months ~ 2 years, and end is recurred again.
Urinary system infection is the general name of the disease such as pyelonephritis, cystitis, urethritis caused by antibacterial and virus etc., belongs to the traditional Chinese medical science " stranguria ", " difficulty in urination " category.General with lumbago, frequent micturition, urgent micturition, dysurea for Major Clinical feature.The traditional Chinese medical science thinks that this sick polyphyly is due to damp invasion of lower energizer, invades kidney and bladder, caused by lower-jiao Qi dysfunction is unfavorable.In patient, children's is more than adult, and women than men is many, and easy recurrent exerbation.The pathogenic bacterium of inflammation of urinary system 80% are caused to be intestinal escherichia coli, Bacillus proteus, streptococcus faecalis.Acute simplex urinary system infection is many to be caused by a kind of pathogen, and the infection of chronic, recurrent exerbation, may have Congenital Anomalies of Urinary System, the patient of nearly 1/2 ~ 1/3 has bladder, ureter reflux, or has the disease such as calculus, chronic renal insufficiency.Play Chinese medicine or ethnic drug effect, alone or Chinese and Western connected applications Compound Solanum Nigrum Pianomide can heat-clearing and toxic substances removing and anti-inflammation in acute stage, and coordinate strengthening vital QI to eliminate pathogenic factors in chronic phase, support the Chinese medicine of kidney yin kidney tonifying gas, effect is better.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the embodiment described.
Claims (6)
1. a Compound Solanum Nigrum Pianomide, is characterized in that, described Pianomide is made primarily of following raw material: Herba Solani Nigri 500 ~ 3000 parts, Herba Hydrocotyles 500 ~ 3000 parts, Ramulus Et Folium Pithecellobii Lucidi 500 ~ 3000 parts.
2. Compound Solanum Nigrum Pianomide according to claim 1, is characterized in that, described Pianomide is made primarily of following raw material: Herba Solani Nigri 500 ~ 1000 parts, Herba Hydrocotyles 500 ~ 1000 parts, Ramulus Et Folium Pithecellobii Lucidi 500 ~ 1000 parts.
3. Compound Solanum Nigrum Pianomide according to claim 1, is characterized in that, described Pianomide is made primarily of following raw material: Herba Solani Nigri 1000 ~ 2000 parts, Herba Hydrocotyles 1000 ~ 2000 parts, Ramulus Et Folium Pithecellobii Lucidi 1000 ~ 2000 parts.
4. Compound Solanum Nigrum Pianomide according to claim 1, is characterized in that, described Pianomide is made primarily of following raw material: Herba Solani Nigri 2000 ~ 3000 parts, Herba Hydrocotyles 2000 ~ 3000 parts, Ramulus Et Folium Pithecellobii Lucidi 2000 ~ 3000 parts.
5. Compound Solanum Nigrum Pianomide according to claim 1, is characterized in that, also comprise: starch 0.5 ~ 5 part, carboxymethyl starch sodium 0.5 ~ 5 part, magnesium stearate 0.1 ~ 1 part.
6. Compound Solanum Nigrum Pianomide according to claim 5, it is characterized in that, starch can also be replaced by one or several following raw materials: polyvidone, octadecanol, hexadecanol, stearic acid, citric acid, microcrystalline Cellulose, dextrin, lactose, mannitol, sodium bicarbonate, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose (L-HPC), crospolyvinylpyrrolidone, magnesium stearate, Pulvis Talci, micropowder silica gel.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334037A (en) * | 2016-08-08 | 2017-01-18 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine composition for treating prostatitis and preparation method thereof |
| CN115919921A (en) * | 2022-08-04 | 2023-04-07 | 广州白云山花城药业有限公司 | Application of pithecellobium clypearia extract in preparation of drugs for preventing coronavirus proliferation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850146A (en) * | 2006-02-21 | 2006-10-25 | 广州莱泰制药有限公司 | Use of extract of Fructus Pithecellobii clypeoriae conrmon Apes Ear-ring Fruit |
| CN100998700A (en) * | 2006-12-26 | 2007-07-18 | 章丽美 | Oral traditional Chinese medicine for treating influenza |
| CN104758481A (en) * | 2015-03-05 | 2015-07-08 | 陈凯 | Folium isatidis houttuynia cordata soup for treatment of wind-heat type common cold |
-
2015
- 2015-11-13 CN CN201510779246.8A patent/CN105213615A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850146A (en) * | 2006-02-21 | 2006-10-25 | 广州莱泰制药有限公司 | Use of extract of Fructus Pithecellobii clypeoriae conrmon Apes Ear-ring Fruit |
| CN100998700A (en) * | 2006-12-26 | 2007-07-18 | 章丽美 | Oral traditional Chinese medicine for treating influenza |
| CN104758481A (en) * | 2015-03-05 | 2015-07-08 | 陈凯 | Folium isatidis houttuynia cordata soup for treatment of wind-heat type common cold |
Non-Patent Citations (3)
| Title |
|---|
| 孙保芳等: "《鄂伦春民族习惯用药》", 31 August 2007 * |
| 徐鸿华等: "《中草药图谱(一)》", 31 July 2007 * |
| 李冈荣等: "《汉方中草药对症图典 第1册》", 30 September 2015 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334037A (en) * | 2016-08-08 | 2017-01-18 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine composition for treating prostatitis and preparation method thereof |
| CN115919921A (en) * | 2022-08-04 | 2023-04-07 | 广州白云山花城药业有限公司 | Application of pithecellobium clypearia extract in preparation of drugs for preventing coronavirus proliferation |
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