CN1381253A - Supercritical CO2 fluid process for extracting and purifying medicinal component from eucommia bark - Google Patents
Supercritical CO2 fluid process for extracting and purifying medicinal component from eucommia bark Download PDFInfo
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- CN1381253A CN1381253A CN 02109711 CN02109711A CN1381253A CN 1381253 A CN1381253 A CN 1381253A CN 02109711 CN02109711 CN 02109711 CN 02109711 A CN02109711 A CN 02109711A CN 1381253 A CN1381253 A CN 1381253A
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- supercritical
- eucommia bark
- extracting
- medicinal component
- fluid process
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Abstract
A process for extracting natural medicine components from eucommia bark by supercritical CO2 fluid and purifying them includes such steps as drying eucommia bark in sun, then crushing, sieving, supertical CO2 extracting at 15-65 deg.C and under 10-40 MPa for 2-10 hr, and natural separation of CO2 from the extracted liquid for cyclic reuse. Its advantages are simple process and equipment, and high output rate.
Description
Technical field
The invention belongs to the pharmaceutical engineering field, relate to modernization of Chinese medicine manufacturing technology, specially refer to a kind of supercritical CO
2The method of natural medicinal ingredients in the fluid extraction purification eucommia bark.
Background technology
The Cortex Eucommiae (Eucommia ulmoides Oliv) is a kind of very cold-resistant Chinese arbor, and similar in shape elm is spent green white.Each province on the south special product reaches in China middle part is as Guizhou, Jiangxi, Yunnan, Sichuan, Shaanxi and other places.The glue that eucommia bark and leaf extract has insulating properties, is used for wrapping up electric wire.Bark can be used as medicine, and has effects such as invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering.Be usually used in treating soreness of waist and knee joint that insufficiency of kidney-YANG, Liver and kidney void lose, aching and limp unable, sexual impotence, frequent micturition and human female void, liability to abortion, frequent fetal movement etc.Modern times also are used for the treatment of hypertension.Traditional extracting method mainly contains steam distillation and solvent extraction method etc.The extraction temperature that these methods adopt is generally higher, and required time is long, the technological process complexity, and easily cause decomposition, variation and the loss of effective ingredient.The problem that the solvent extraction rule also exists dissolvent residual to be difficult to avoid.Therefore, utilization modern high technology means, reform traditional carry medicine, pharmaceutical technology, to obtain high-quality pharmaceutical raw material, make it to meet the strict demand of modern medicine, be of great practical significance.CO
2Nontoxic, not flammable, cheap and easy to get, therefore have remarkable advantages as extractant.Use supercritical CO
2The Cortex Eucommiae effective ingredient that the fluid extraction method obtains has the characteristic of pure natural, is the green extractive technique of compliance with environmental protection requirements.
Summary of the invention
The purpose of this invention is to provide a kind of supercritical CO of using
2The method of natural medicinal ingredients in the fluid extraction purification eucommia bark.This method technological process is short, method is simple.With CO
2Be solvent, can realize eco-friendly requirement, and kept the pure natural characteristic of product.Both no solvent residue, also problem such as non-pollutant discharge in the product.Gained light green Cortex Eucommiae extract and CO
2Natural separation, and CO
2Can use by recirculation.Solved the difficult problem of dissolvent residual, environmental pollution.
Technical scheme of the present invention is to realize a kind of supercritical CO of using
2The method of natural medicinal ingredients in the fluid extraction purification eucommia bark.Its step is, at first eucommia bark carried out dry in the sun at normal temperatures, pulverizes then, sieves.With eucommia bark is raw material, with supercritical CO
2Be extractant,, extract in 15～65 ℃ of scopes of temperature that blood pressure lowering step by step under 15～65 ℃ of conditions extracted 2～10 hours at pressure 10～40MPa.Resulting light green Cortex Eucommiae extract and CO
2Natural separation, and CO
2Can use by recirculation.
Effect of the present invention and benefit are to compare with traditional steam distillation and solvent extraction, and this method flow is short, and equipment is simple, easily realizes industrialization.The yield of effective ingredient and product quality all are better than traditional method, and no solvent residue, non-environmental-pollution.
The specific embodiment
Below by embodiment to method afford further instruction of the present invention.
Embodiment 1
With the Cortex Eucommiae 60g of electronic balance weighing, with small-sized plant pulverizer it is ground into the powder of 28～36 order sizes, in the stainless steel charging basket of packing into equably then available from the pharmacy.Under pressure 40MPa, 65 ℃ of conditions of temperature, use supercritical CO
2Continuous extraction 120min.By the separator sampling, obtain light green Cortex Eucommiae extracting solution 1.68g.
Embodiment 2
With the Cortex Eucommiae 60g of electronic balance weighing, with small-sized plant pulverizer it is ground into the powder of 28～36 order sizes, in the stainless steel charging basket of packing into equably then available from the pharmacy.Under pressure 20MPa, 15 ℃ of conditions of temperature, use supercritical CO
2Continuous extraction 360min.By the separator sampling, obtain light green Cortex Eucommiae extracting solution 0.72g.
Embodiment 3
With the Cortex Eucommiae 60g of electronic balance weighing, with small-sized plant pulverizer it is ground into the powder of 28～36 order sizes, in the stainless steel charging basket of packing into equably then available from the pharmacy.Under pressure 10MPa, 35 ℃ of conditions of temperature, use supercritical CO
2Continuous extraction 600min.By the separator sampling, obtain light green Cortex Eucommiae extracting solution 0.58g.
Claims (1)
1. supercritical CO
2The method of natural medicinal ingredients in the fluid extraction purification eucommia bark is that eucommia bark is carried out dry in the sun at normal temperatures, pulverizes then, sieves, and it is characterized in that: with eucommia bark is raw material, with supercritical CO
2Be extractant,, extract in 15～65 ℃ of scopes of temperature that blood pressure lowering step by step under 15～65 ℃ of conditions extracted 2～10 hours at pressure 10～40MPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02109711 CN1381253A (en) | 2002-05-09 | 2002-05-09 | Supercritical CO2 fluid process for extracting and purifying medicinal component from eucommia bark |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02109711 CN1381253A (en) | 2002-05-09 | 2002-05-09 | Supercritical CO2 fluid process for extracting and purifying medicinal component from eucommia bark |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1381253A true CN1381253A (en) | 2002-11-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02109711 Pending CN1381253A (en) | 2002-05-09 | 2002-05-09 | Supercritical CO2 fluid process for extracting and purifying medicinal component from eucommia bark |
Country Status (1)
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| CN (1) | CN1381253A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292671C (en) * | 2005-05-31 | 2007-01-03 | 武汉理工大学 | Method for producing tu-chung instant tea and its water drinking product |
| CN101352616B (en) * | 2008-09-11 | 2010-06-09 | 中健行集团有限公司 | Method for preparing pine tree bark extract using barrier separation integrated process engineering |
| CN101920127B (en) * | 2009-06-15 | 2013-03-06 | 福建中烟工业有限责任公司 | Device for extracting natural plant scent components at low temperature and extracting process thereof |
| CN106176892A (en) * | 2016-08-29 | 2016-12-07 | 马健 | The method extracting water soluble ingredient from eucommia bark |
-
2002
- 2002-05-09 CN CN 02109711 patent/CN1381253A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292671C (en) * | 2005-05-31 | 2007-01-03 | 武汉理工大学 | Method for producing tu-chung instant tea and its water drinking product |
| CN101352616B (en) * | 2008-09-11 | 2010-06-09 | 中健行集团有限公司 | Method for preparing pine tree bark extract using barrier separation integrated process engineering |
| CN101920127B (en) * | 2009-06-15 | 2013-03-06 | 福建中烟工业有限责任公司 | Device for extracting natural plant scent components at low temperature and extracting process thereof |
| CN106176892A (en) * | 2016-08-29 | 2016-12-07 | 马健 | The method extracting water soluble ingredient from eucommia bark |
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