CN1373653A

CN1373653A - Sheet-like devices

Info

Publication number: CN1373653A
Application number: CN00811326A
Authority: CN
Inventors: R·S·迪克辛; P·J·艾雷; T·L·约翰逊; M·J·勒布兰克
Original assignee: Procter and Gamble Ltd
Current assignee: Procter and Gamble Ltd; Procter and Gamble Co
Priority date: 1999-07-06
Filing date: 2000-06-30
Publication date: 2002-10-09
Also published as: WO2001001952A1; KR20020027478A; WO2001001816A1; CZ200236A3; AU4340900A; MXPA02000267A; AU3246000A; BR0012233A

Abstract

The present invention relates to pre-formed, unilamellar, sheet-like devices (10, 110, 210, 310, 410, 510, 610, 710, 810) for delivering benefit agents to the skin, hair or nails. The devices are patches or masks for cosmetic or therapeutic use. The devices have a non-planar topography on at least one surface (14, 114, 214, 314, 414, 514, 614, 714, 814; 16, 116, 216, 316, 416, 516, 616, 716, 816) and are less obtrusive. The present invention also encompasses methods of producing such devices.

Description

Pellet part

Affiliated field

The present invention relates to new preformed monolayer pellet part.The present invention is specifically related to the preformed monolayer pellet part of paster or facial film form, wherein contains at least a polymer gel and forms agent, and it is used for effective ingredient is transported to skin, hair or fingernail.Described device is applicable to the part conveying of at least a effective ingredient, and it has mechanical performance such as the intensity and the pliability of improvement.In addition, device right and wrong of the present invention are conspicuous, and in use can with the profile good fit of application site.

Background technology

The known in the art employing contains polymer gel and forms the paster of agent or facial film device and substitute products such as cream frost or water preparation and be used for the aesthetic nursing of skin, hair or fingernail, or is used to promote to burn or the healing of wound.Various Beauty sticking pieces or device were commercially available already or disclosedly can be used for carrying skin care activity composition such as vitamin, anti-acne active ingredient, moisturizing agent etc.That disclose in the document and commercially available paster and device also can be used as the process useful of percutaneous dosing in medical domain.But there are shortcoming in many these class pasters or device on its physical product forms, thereby cause user or the perceptible disadvantageous operating characteristic of wearer.For example, some paster or device can be too moist or sticky, and the contained gel former of paster or device can't form the solid gel structure, thereby cause paster or device to be difficult to operate or be used for skin.And other pasters or device have strong viscosity and sealing, make discomfort when wearing with removal, and many pasters can not make effective ingredient effectively discharge and infiltration.

Some paster or device need form at the scene on skin, use trouble thereby cause.US-A-4 for example, 291,025 relate to the topical dressings of hot reversible agar gel, wherein contain 5-12% agar, the 20-75% diethylene glycol, and water adds to 100%; And relate to the method for preparing described dressing.The composition (for example vitamin, antibiotic) that also can contain gel hardening agent and specific use in the said composition.US-A-4, an aspect of 291,025 inventions relates to the high-intensity contractibility agar gel of preparation solid, is subdivided into less piller or tablet then.On the other hand, change into colloidal sol through the heating agar gel then, in the application region, the original place cooling forms removable gel form with sol coating.

In addition, some paster or device are too dry or do not have a pliability, thus can not with the profile good fit of application surface.EP-A-161 681 discloses a kind of gel film, wherein contains polysaccharide and polyatomic alcohol water solution.The preferred polysaccharide that is applicable to gel film is the mixture or the carrageenin itself of carrageenin and galactomannan.Randomly contain drug component in the said composition, as skin irritant, antiinflammatory, analgesics and antibiotic.It is transparent or opaque wherein disclosing this gel film, has pure and fresh sense and good adhesiveness, and has sufficient elasticity, ductility and robustness.

Pliability and intensity are another key properties of gel device.WO97/17944 discloses the cosmetic formulation that is made of gel rubber material, this gel rubber material is by containing solubility alginate (0.1-5%), agar (0.01-0.5%), pectin (0.01-0.5%), the polysaccharide equilibrium mixture of xanthan gum (0.05-1%) and excess water constitutes.Gel rubber material randomly is rich in water solublity or water-dispersible active component.This gel rubber material can be processed into the structuring gel, it it is said that easy operating also can adapt with skin surface.

WO90/14110 discloses the pharmaceutical preparation from support sheet, deposited pad or wafer form with requirement size, shape and thickness, wherein contains the xanthan gum of water-insoluble alginate and suspending agent such as independent application or the mixture of xanthan gum and tracasol.It is said that Gellan gum also is the suspending agent that is suitable for.Suspending agent in the preparation also can be used as gel former.Can randomly contain antiinflammatory or antibacterial, iodine in the said preparation.The preparation of sheet or wafer form can be flexible, and can be used for the plastic lining back and form whole surgical dressing, and gel can be naked or be hidden through the tulle face.

US-A-4,318,746 relate to a kind of gel, it contains at least 0.5% first polymer, it can disperse, dissolving or hydration in hot water, and can in cooling procedure, form or be formed rigid gel, also contain at least 2% second polymer, it is insoluble to hot water and can dissolving or hydration in cooling procedure, its can with first polymer-compatible, and water.Document description gel be firm, cohesion and viscosity, and can be for example as electrode or be used for topical.It is that it has certain rigidity when being lower than 60-65 ℃ that document has been summarized one of advantage of gel, and is viscosity.

JP-A-63-200760 discloses a kind of double-layer paster, wherein contains gelled matrix and supporting spring (or end liner).The one side of its description proposition gelled matrix and contact skin is preferably flat.Perhaps, comprise the groove (accompanying drawing 3) of netted arrangement, the labelling of impression or analog (accompanying drawing 2), the groove of parallel array (accompanying drawing 5) or the projection (accompanying drawing 7) of arranging with the one side of contact skin.Comprise protein (gelatin, casein, albumin or sericin (serecin)) or a kind of water-soluble polymer in the gelled matrix, wherein added inorganic filler, wetting agent, can add binding agent and/or cross-linking agent.In the mould of required form, make double-layer paster through die pressing.

WO98/17287 relates to the flexible polysiloxanes pad of hollow, and it can be used for the treatment of keloid and hypertrophic cicatrix by produce negative charge near cicatrix.Pad can be made by structurized polysiloxanes lamella, and term " structurized " is meant and will for example comprises the irregular surface of corner, zigzag or dependency structure feature that it can have regular or irregularly shaped or outward appearance.Point out that wherein the uneven distribution that can cause electric charge is handled in structuring.The wherein also unexposed method that is used for structuring polysiloxanes lamella.

US-A-4 discloses the polymer sheet layer as burn dressing in 289,125, and its side towards skin is through structurized at least.Point out that wherein this structuring is suitable for the wound onal cavity volume is provided, and can be attached on the wound site.Wherein disclose and simultaneously had or the two sides all has the burn dressing of patterned surface.Accompanying drawing 1D discloses a kind of single layer device, and wherein the two sides is structurized.The structured fabric lamella can be used as the skeleton of load aggregation thing, then through cured.Therefore can remove the skeleton tissue layer by the solvent lixiviate, obtain complete monolayer from support type polymer sheet layer.Accompanying drawing 5F-5I discloses a kind of laminated device with one " structuring " surface.Wherein comprise the polymeric film with smooth surface, wherein local embedding can make its surface have the material of fabric construction.Should in bury material can be naked or through tulle face or wire side or above-mentioned tissue layer (through or without the casing play lixiviate) hide.Accompanying drawing 6D has described a kind of non-stratiform embodiment, and it has one " structuring " surface.Textile material can extend on suitable surface, and as the casing play of load aggregation thing thin layer, this thin film can constitute continuous phase with the polymer that covers on the textile material.(referring to accompanying drawing 6C).This textile material then can be through lixiviate.

WO94/02674 relates to the pad through the bilateral structure processing, wherein comprise the scraps of paper layer that is laminated on the synthetic fibers nonwoven lamella, have repeat patterns on it, this pattern comprises at least two continuous delimited area simultaneously, its thickness difference, or comprise hole with rule or irregular spacing.Double-decker can make same pad have gentle and powerful cleaning action simultaneously.

WO98/50085 relates to a kind of articles for use, its can be for example wound dressing or diaper with applying bar (target strip).These articles for use comprise egative film and structurized low viscosity gum coating of modifying through inferior light.The document points out that the inferior light modification of surfaces of wound dressing can make through " mechanism ", and so unobvious after can making dressing be used on the skin.

US-A-5,026,446 relates to the deposited bar through the physics polishing that diaper is used.This physics polishing helps the cohesive of adhesive seal adhesive tape and deposited bar.

Although paster in above-mentioned beauty treatment and the field of medicaments or lamella have progradation to obtaining required physics and application characteristic, but a kind of like this preforming monolayer pellet part from support is described in these documents: this device have the mechanical performance of required intensity, robustness and flexibility and required easy operating, non-conspicuous property and can with in use can with the operating characteristic of the comfortableness of application surface good fit.

Be surprised to find that at present can prepare a kind of from support, high-intensity preformed monolayer pellet part, its have can with enough pliabilities of application surface good fit.This device has nonplanar structure according to a first aspect of the invention, wherein according to concrete application surface this structure is selected, so that its easy operating and application.For example the crestal line of this device periphery thickening can make this device easy operating and firm, and can fit well at the high application surface position of curvature in thin zone.In addition or alternatively, the lip-deep patterned surface away from skin, hair or fingernail when using of device can make the reduction of the conspicuous property of device.Can reach required physical characteristic by chemical composition and the rheological properties of selecting agglomerative device, consider getting in touch between intensity and pliability during selection, and can obtain required application characteristic by selecting suitable nonplanar structure for use, wherein this nonplanar structure is at least two continuous border region, and their average thickness is not identical simultaneously with suitable patterned surface.

The syneresis amount of the preferred preformed monolayer pellet part of the present invention is low, and it can make the device sense of touch moistening, and helps to provide cooling feeling.The liquid on surface can be easy to make device adhere in application surface, thereby can avoid using this gel of additional adhesive coverage or employing to cover binding agent on the egative film.

Monolayer pellet part of the present invention need not to adopt isolation or non-isolation gasket material (being commonly called egative film) to carry out support or reinforcement.If but adopted egative film, it could combine with the monolayer pellet part, and provides further support or invigoration effect to it.In addition, egative film also can be used for preventing the evaporation of active component, or is used as a kind of structure that device is attached to skin when its periphery has binding agent.Egative film can be impregnated with, adheres to or be laminated on the surface of device.

EP-B-507,160 relate to a kind of preparation for external application to skin, wherein contain the medicated layer that is positioned on the support pad, comprise lignocaine and viscous gel matrix in the medicated layer, wherein contain the 0.5%-50% water-soluble high-molecular substance, the water of 20%-70%, and the water-retaining agent of 1%-70%.Wherein the support pad of Shi Yonging is described as flexible material, as non-woven material.

If adopt egative film that further support or invigoration effect are provided, it must be compatible with gel.If gel and egative film generation slabbing, then egative film and gel are incompatible.Even find that gel combination has required pliability and intensity, still there is the difficulty of seeking the egative film that matches with these gels, its mediella should be compatible with these desirable characteristics of gel.But but but the egative film of deformation is combined paster or the facial film device that must not make deformation with the gel phase of deformation.Except that the problem that has slabbing, but the egative film of many deformation often has porous to a certain degree, thereby can make moistening gel soak into egative film and form firm gel networks in the egative film fiber.It is generally acknowledged that these network structure can reduce the pliability of obtained device.In addition, egative film possibly can't be provided for the paster or the facial film device of the outward appearance with non-conspicuous property on skin, hair or the fingernail.This usually will be according to the selection of egative film and characteristic thereof is decided.

Pellet part of the present invention is preferably improved looks or is treated with paster or facial film.

Summary of the invention

First aspect of the present invention relates to a kind of preformed monolayer pellet part that is used for carrying effective ingredient on skin, hair or fingernail, and this device comprises first and second displaced surface of dividing through device periphery; This device contains at least a effective ingredient and at least a polymer gel forms agent; And this device has nonplanar structure on the one side at least in first and second surfaces.

Second aspect of the present invention provides a kind of preformed monolayer pellet part that is used for carrying effective ingredient on skin, hair or fingernail, this device comprises first and second displaced surface of dividing through device periphery, and this device comprises at least a effective ingredient and at least a polymer gel forms agent; And this device has nonplanar structure on the one side at least in first and second surfaces, nonplanar structure comprises at least two continuous border region, and it does not have identical average thickness simultaneously.

The 3rd aspect of the present invention provides a kind of preformed monolayer pellet part that is used for carrying effective ingredient on skin, hair or fingernail, and this device contains at least a effective ingredient and at least a polymer gel forms agent; And this device comprises first and second displaced surface of dividing through device periphery, during application, first surface contacts with skin, hair or fingernail, second surface has nonplanar structure, this nonplanar structure comprises patterned surface, it is the negative-appearing image on a structurized surface of formation (structuring action face), and the structure of this formation patterned surface adopts Ra to be defined greater than 10 μ m.

The patterned surface that device of the present invention had preferably not only outward appearance have visible structuring, and have the structuring sense of touch.

Device of the present invention is suitable for the part and is used for skin, hair or fingernail.These devices can provide fabulous operating characteristic, ease for operation and comfortableness during as non-conspicuous property, comfortableness, stickiness, pliability, visual appearance, intensity, topical application.In addition, device of the present invention has fabulous mechanical property, and can form high-strength structure, and it is flexible, and has elasticity to a certain degree.The syneresis amount of preferred devices of the present invention is low, and the application characteristic that hydration can further be provided in topical application and moisten.

A fourth aspect of the present invention provides the method for the preforming monolayer pellet part that relates in a kind of production the present invention first or the second aspect, this method may further comprise the steps: make a kind of mixture that forms gel in mould, wherein contain at least a effective ingredient and at least a gellable polymer gel formation agent, at least the one side of this mould is the negative-appearing image of (each) nonplanar structure, this nonplanar structure comprises at least two border region, it does not have identical average thickness simultaneously, perhaps comprise patterned surface, it is for the negative-appearing image of structuring action face, its structure adopts Ra to be defined greater than 10 μ m, or above two kinds of situations; Make this one-tenth glue mixture gelling then.In preferred embodiments, mould has two opposite structuring action face, and its structure adopts Ra to define greater than 10 μ m, so that impress out first and second opposite on this device patterned surfaces.More preferably can further make nonplanar structure by this mould, this structure comprises at least two border region, they do not have identical average thickness simultaneously at least one surface of device, preferably when application device second surface away from skin, hair or fingernail.

The 5th aspect of the present invention provides the method for the preforming monolayer pellet part that relates in a kind of production the present invention first or the third aspect, this method may further comprise the steps: make a kind of one-tenth glue mixture in mould, wherein contain at least a effective ingredient and at least a gellable polymer gel formation agent, wherein the first surface of this mould has the negative-appearing image of device first surface; And the second structuring action face is contacted with second device surface that becomes the glue mixture, make into the gelling of glue mixture; Remove this structuring action face down from device then.

The 6th aspect of the present invention provides and a kind of at least a effective ingredient is transported to method on skin, hair or the fingernail, this method comprises that the device that first, second or the third aspect of the present invention are related to contacts with skin, hair or fingernail, contains at least a beauty treatment effective ingredient and at least a polymer gel in this device and forms agent.

Brief Description Of Drawings

Accompanying drawing 1a, 1b and 1c are plane graph, profile perspective and the perspective views of first kind of specific embodiments of the present invention first or the related device of second aspect.

Accompanying drawing 2 and 3 is second kind and profiles of the third specific embodiments of the present invention second or the related device of the third aspect.

Accompanying drawing 4 is perspective cutaway view, of the 4th kind of specific embodiments of the present invention first, second or the related device of the third aspect.

Accompanying drawing 5 is perspective cutaway view, of second kind of specific embodiments of the present invention first or the related device of the third aspect.

Accompanying drawing 6 is sketch maps of the 5th kind of embodiment of the related preformed monolayer pellet part of the present invention first or second aspect, is located at user's face.

Accompanying drawing 7a and 7b are the plane graph and the profiles of device in the accompanying drawing 6.

Accompanying drawing 8 is sketch maps of the 6th kind of specific embodiments of the present invention first or the related device of second aspect, is positioned at user's face.

Accompanying drawing 9 is plane graphs of preformed monolayer pellet part in the accompanying drawing 8.

Accompanying drawing 10 is sketch maps of the 7th kind of specific embodiments of the present invention first or the related device of second aspect, is positioned at user's face.

Accompanying drawing 11 is plane graphs of preformed monolayer pellet part in the accompanying drawing 10.

Accompanying drawing 12 is plane graphs of the 8th kind of embodiment of the device that relates to of third aspect present invention, and wherein the first surface of this device and second surface are handled through structuring.

Detailed Description Of The Invention

Preformed synusia shape device of the present invention comprises at least a effective ingredient and at least a polymer gel forms agent, and various following optional member.Unless otherwise indicated, all content and ratio are all to account for the gross weight of compositions in the device.When with egative film during, do not comprise the weight of egative film in the calculating device during gross weight of compositions as the adnexa of device.

Here the term of Cai Yonging " preformed " is meant that described device is made with predetermined thickness, shape and size product form, wherein this device can take out from any related packaging, place or be covered on the application surface with finger, need not to sprawl, embrocate or apply product in application surface.Device of the present invention is preferably packaged in the protective package thing of sealing.

Here the term of Cai Yonging " pellet part " is meant that described device is that beauty treatment is used or medical plaster or facial film form, wherein paster is continuous patch, and have according to the concrete position of skin, hair or the fingernail of need nursing and predetermined shape, facial film then is the discrete patch that is used to cover facial zone, has perforate at eye, nose and mouth on it.

Here the term of Cai Yonging " monolayer " is meant that described device is single lamella, and it is from the support form.

Here the term of Cai Yonging " nonplanar structure " is meant at least two continuous border region that do not have identical average thickness simultaneously.Perhaps or alternatively, term " nonplanar structure " is meant structurized surface, it is the negative-appearing image of structuring action face, and the structure of structuring action face adopts Ra to be defined greater than 10 μ m.Here the term of Cai Yonging " Ra " is meant with respect to the suitableeest plane (best fitplane), based on the average deviation on surface, sees hereinafter the part that is entitled as " appraisal procedure " for details.

Phrase " border region that links to each other that does not have identical average thickness simultaneously " is meant that there is the visible boundary of vision in the zone that links to each other on the device, and when the little degree varied in thickness (the structuring effect provides as described in the present invention) that exists at specified point by mean time, its average thickness difference.

Here the term of Cai Yonging " water miscible " be meant under the room temperature or under heating condition gellable polymer gel form the ability that agent is dissolved in the aqueous solution and forms continuous phase.

Here the term of Cai Yonging " syneresis " is meant that gel oozes out the process that shrinks because of liquid in put procedure.There is no particular restriction in theory, it is believed that gel combination can form three dimensional matrix, its can in conjunction with or embedding composition in other compositions.Syneresis it is believed that and comprises that spontaneous being separated of initial homogeneous system forms successive gel phase and liquid phase.Transudate is a solution, and its composition of forming the initial gel of basis is decided.When preferred device of the present invention was used for the application region, device volume reduced, thereby made bonded composition such as water or effective ingredient release and infiltration application region in the gel-type vehicle.

Here the term of Cai Yonging " polysaccharide " is meant straight chain, side chain or the cross linked polymer of natural existence or the synthetic monosaccharide unit that makes of warp, and it is scattered in the water under low dried concentration is to expand, and makes the water gelling.

Here the term of Cai Yonging " compression failure percentage ratio " is meant and weighs the flexible yardstick of gel.Described method sees hereinafter the part that is entitled as " appraisal procedure " for details.

Here the term of Cai Yonging " compression failure power " is a yardstick of weighing gel strength.Described method sees hereinafter the part that is entitled as " appraisal procedure " for details.

Here the term of Cai Yonging " repetitions patterns " is meant the pattern that repetitive constitutes, and it is to weigh in the pattern repetitive end points to the yardstick of the distance of terminal point.

The nonplanar structure of device of the present invention can be that pattern is multiple or non-repetitive.Preferred repeat patterns is sinusoidal, jagged or conical.Preferred repetitions patterns is about 0.1mm to about 10mm, preferably is about 0.5mm to about 5mm.When comprising structurized first surface and second surface in the device, the pattern on two sides can be identical or different, and each pattern can be multiple or non-repetitive.If pattern all is multiple, this repetitions patterns can be identical or different.In the identical embodiment of repeat patterns, the pattern that is made of on the two sides repetitions patterns can be a linear array, and thus, the projection of one side can be directly corresponding to the projection or the groove of another side, and perhaps the convex-concave on two sides is interlocked.Preferred pattern is interlocked, because find to adopt the conspicuous property of its vision of device of interlaced pattern low.

In the accompanying drawings, adopt similar numeral for similar portions.

Accompanying drawing 1a, 1b and 1c are first kind of embodiments of preformed monolayer pellet part of the present invention, all represent with 10.The profile of accompanying drawing 1b is analysing and observe along the 1b-1b line on the accompanying drawing 1a.The periphery 12 of device 10 limits isolated first surface and second surface 14,16.Device 10 has nonplanar structure on second surface 16.This nonplanar structure comprises the thicker region of boundary, and its form is and periphery 12 flanges that link to each other 18, and the thicker region of another boundary, and its form is the convex ridge 20 that is positioned at peripheral 12 central authorities, and the thinner region 22 of boundary.

In the use, plan will be that planar first surface 14 contacts with user's skin, hair or fingernail substantially.Certainly, first surface and

second surface

14,16 also can be the nonplanar structure (not shown).Equally, nonplanar structure also can only be positioned at (not shown) on the first surface 14.Device 10 for example is suitable for carrying effective ingredient to user's eye below or the skin skin area around the lip.

Accompanying drawing 1a, the device 10 shown in 1b and the 1c can have various suitable sizes, and this will decide according to its purposes and product attribute.Device can be crescent on the whole, and shape is limited in the imagination rectangle (notional rectangle) of about 60mm * about 27mm.Substantially for the shape of crescent has the first and second crooked tips, they and orthogonal first longitudinal edge of the imagination are near (not shown).The size of device 10 is respectively 13mm, 17mm, and 20mm, 23mm and 21mm become 22.5 ° with the cross point of orthogonal transversal centerline of the imagination and orthogonal first longitudinal edge of the imagination, and 45 °, 90 °, 135 ° and 157.5 ° of angles.

Shown in the accompanying drawing 2 is second kind of embodiment of the preformed monolayer pellet part that relates to of the present invention first or second aspect, wholely represents with 110.The periphery 112 of device 110 has been divided isolated first surface and second surface 114,116.Device 110 has nonplanar structure on second surface 116, this nonplanar structure comprises the thicker region of boundary, and its form is and periphery 112 flanges that link to each other 118, and the thinner region 122 of boundary, the thicker region and the thinner region 118,122 of boundary do not have identical average thickness simultaneously.Flange 118 helps to prevent that device 110 from tearing in operation, and in use can fit better with the bigger position of curvature on user's skin in thin zone 122.Preferably thinner region 122 has additional nonplanar structure on second surface 116 at least, comprises patterned surface, and it is the negative-appearing image of structuring action face, and the structure of this structuring action face adopts Ra to be defined (not shown) greater than 10 μ m.

Shown in the accompanying drawing 3 is the third embodiment of the device that relates to of the present invention first or second aspect, wholely represents with 210.The periphery 212 of device 210 has been divided isolated first surface and second surface 214,216.Device 210 has nonplanar structure, and this nonplanar structure comprises the thicker region of boundary, and its form is the convex ridge 220 that is positioned at peripheral 212 central authorities, and with the periphery 212 boundary that link to each other thinner region 222.Convex ridge 220 can be operation bigger intensity and rebound elasticity is provided, and in use can fit better with the big application surface of curvature in thin zone 222.

Shown in the accompanying drawing 4 is the present invention first or second or the phantom of the 4th kind of embodiment of the preformed monolayer pellet part that relates to of the third aspect, wholely represents with 310.Device 310 comprises the first surface and the second surface 314 of separation, 316, this device 310 comprises nonplanar structure, and this comprises the thicker region of a plurality of boundary this structure, its form is for being positioned at the thinner region 322 of the intermediary interval of peripheral (not shown) convex ridge 320 and a plurality of boundary.As shown in the figure, although device also can be along the transversaryization of convex ridge, along the vertical unstructured effect of convex ridge.But described nonplanar structure also can comprise patterned surface, and it is the negative-appearing image of structuring action face, and structure adopts Ra to be limited greater than 10 μ m.

Shown in the accompanying drawing 5 is the phantom of second kind of embodiment of the preformed monolayer pellet part that relates to of the present invention first or the third aspect, wholely represents with 410.Device 410 comprises the first surface and the second surface 414 of separation, 416, first surface 414 contacts with skin, hair or fingernail in use, second surface 416 has nonplanar structure, comprise patterned surface, it is the negative-appearing image of structuring action face, and wherein structure adopts Ra to be defined greater than 10 μ m.First surface and/or second surface 414,416 can also have nonplanar structure, wherein comprise at least two regional (not shown) that do not have the boundary of identical average thickness simultaneously.First surface 414 also can randomly have nonplanar structure, and it comprises patterned surface, and it is the negative-appearing image of structuring action face, and structure adopts Ra to be defined (not shown) greater than 10 μ m.

Accompanying drawing 6, shown in 7a and the 7b is the 5th kind of embodiment of the preformed monolayer pellet part that relates to of the present invention first or second aspect, wholely represents with 510.The profile of accompanying drawing 7b is analysing and observe along the 7b-7b line on the accompanying drawing 7a.Device 510 comprises the first surface and the second surface 514,516 at the interval of being divided by irregular periphery 512.Device 510 comprises nonplanar structure, wherein comprises two continuous thin and thicker border region 522,524 respectively, and it does not have identical average thickness simultaneously.In this embodiment, nonplanar structure is positioned on the second surface 516.Nasal region good fit that can be bigger than thin zone 522 with curvature.

Shown in the accompanying drawing 8 and 9 is the 6th kind of embodiment of the preformed monolayer pellet part that relates to of the present invention first or second aspect, wholely represents with 610.Device 610 is facial films, shape and size are made into can cover substantially user's face, and have first and second surfaces 614 at interval, 616, device 610 has nonplanar structure on second surface 616, wherein comprise at least two continuous thin and thicker border region 622,624 respectively, it does not have identical average thickness simultaneously.Device 610 also comprises perforate 626, and its shape and size are made into to hold the specification of eyes of user, nose and mouth.Thin zone 622 is along being alternate form on the periphery 612, adjacent to cut-out 628.During application, as shown in Figure 8, adjacent thinner region 622 contacts with each other, thereby this preformed monolayer pellet part 610 is used for carrying at least a effective ingredient to skin of face for covering the facial film form of user's face substantially.

Shown in the accompanying drawing 10 and 11 is the 7th kind of embodiment of the preformed monolayer pellet part that relates to of the present invention first or second aspect, wholely represents with 710.Device 710 is facial films, and shape and size are made into can cover substantially user's face.The slit 730 of periphery is adjacent to periphery 712.This device has nonplanar structure on second surface 716, wherein comprise at least two continuous thin and thicker border region 722,724 respectively, and it does not have identical average thickness simultaneously.During application, thin zone 722 is adjacent with nose/mouth with user's eye to fit.Device 710 also comprises slit 732 and perforate 726, and its shape and size are made into can hold respectively the specification of eyes of user, nose and mouth.In the use, lapping mutually between the opposite face of peripheral slit 730, thus make preformed monolayer pellet part 710 for covering the facial film form of user's face substantially.

Shown in the accompanying drawing 12 is the 8th kind of embodiment of the device of the present invention first, second or the third aspect, wholely represents with 810.Device 810 comprises the first surface and the second surface 814 at the interval of being divided by periphery 812,816, and device 810 is included in the nonplanar structure on the second surface 816, thicker region comprising boundary, its form is and periphery 812 flanges that link to each other 818, the thinner region 822 that also comprises boundary, the thickening of this boundary does not have identical average thickness simultaneously with thin zone 818,822.In addition, device all comprises patterned surface on first surface and second surface 814,816, and it is the negative-appearing image of structuring action face, and wherein structure adopts Ra to be defined greater than 10 μ m.

In addition or alternatively, paster or facial film device 10,110,210,310,410,510,610,710,810 nonplanar structure also can contain the sign (not shown).Sign can be a trade mark form for example, for little mark device and/or have a series of alphabetic characters.

Preferred nonplanar structure is positioned at second surface (when using away from user skin, hair or fingernail), and it can be a patterned surface, or at least two border region that do not have identical average thickness simultaneously, or has above two kinds of forms simultaneously.More preferably nonplanar structure is to be positioned at second surface (when using away from user skin, hair or fingernail), it is patterned surface and at least two border region that do not have identical average thickness simultaneously, also have nonplanar structure in addition on the device first surface, it is a patterned surface.Polymer gel forms agent

As a necessary component of preformed monolayer pellet part of the present invention, contain at least a polymer gel in the device of the present invention and form agent.The consumption of polymer gel formation agent generally is less than about 70% of composition total weight in the preformed pellet part of the present invention, preferably is lower than 50%, more preferably less than 30%, and particularly is lower than 10%.

It can be natural or synthetic source that this at least a polymer gel forms agent.It can be from agglomerative that this at least a polymer gel forms agent, or can only form gel jointly with other compositions.Perhaps, this at least a gel former can be through physics or chemical crosslinking.

It can be from agglomerative that polymer gel forms agent, or can only form gel jointly as sugar, alcohol or monovalence or multivalent salts with other compositions.Monovalence and multivalent salts also can be used as the gel hardening agent, are used to increase the intensity of preformed monolayer pellet part of the present invention.The cation that is suitable for can be selected from monovalence or polyvalent cation, for example, and potassium, sodium, ammonium, zinc, aluminum, calcium and magnesium ion, or their mixture.Be suitable for can being selected from chloride ion, nitrate anion, sulfate radical, carbonate, borate and phosphate radical anion with the bonded anion of aforesaid cation, or their mixture.

Physical crosslinking is meant that cross-linked form that polymer has is not chemical covalent bond but has physical characteristic, thereby forms zone with high-crystallinity or the zone with high glass transition point on device.Chemical crosslinking is meant the polymer through chemical bonding.Preferred polymers by radiotechnology as heat-, electron beam-, ultraviolet-, γ or microwave radiation carry out chemical crosslinking.In addition, when forming chemical crosslinking in the system, can in pre-composition, add polyfunctional crosslinking agent and/or radical initiator and be used for through radiation the time, causing cross-linking reaction.The consumption of these components is preferably up to 5% (weight).

It can be water miscible or non-water-soluble that polymer gel forms agent.It is that water-soluable gel forms agent that preferred at least a polymer gel forms agent.Polymer gel forms agent also can comprise water-insoluble gel former, comprises that organopolysiloxane gel forms agent/polysiloxanes (organopolysiloxane resins) or block copolymer thermoplastic elastomer (TPE).The non-soluble polymer gel former

Polysiloxanes can be described as the organopolysiloxane resins of soluble hydroxyl functional group, wherein comprise R ₃SiO _1/2Siloxane unit and SiO _4/2, wherein R is a univalent perssad, is selected from the alkyl and the halogenation alkyl that contain 1-20 carbon atom.R ₃SiO _1/2And SiO _4/2In the nomenclature principle, 1/2 and 4/2 represent on the molecule shown in the number of half bond.R for example ₃SiO _1/2In, one 1/2 key is positioned on the oxygen, another half bond and other atomic linkages.This group also can be expressed as:

Equally, SiO _4/2In represented molecule, comprise 4 1/2 keys, another half bond of each key and other molecular linkages.This group also can be expressed as:

Here the term of Cai Yonging " water-soluble resin " is meant gellable polysiloxane, and it can be dissolved in liquid hydrocarbon such as benzene,toluene,xylene, the heptane etc. basically fully, or is dissolved in the polyorganosiloxane fluid, as ring-type or straight chain polydiorganosiloxanepolyurea.Preferred resin dissolves in the polyorganosiloxane fluid.

In the polyorganosiloxane resin formula, R represents univalent perssad, is selected from alkyl and halogenation alkyl, and its carbon atoms preferably is less than 20, most preferably contains 1-10 carbon atom.The example of the R that is suitable for comprises alkyl, as methyl, and ethyl, propyl group, amyl group, octyl group, undecyl, octadecyl and other groups; Alcyl is as cyclohexyl; Aryl such as phenyl, tolyl, xylyl, benzyl, α-Jia Jibenyixi base, 2-phenethyl and other groups; Thiazolinyl such as vinyl; And the chlorination alkyl, as the 3-chloropropyl, Dichlorobenzene base or other groups.

Be to increase the dissolubility of polyorganosiloxane resin in polyorganosiloxane fluid, wish to prevailing organic group in the polyorganosiloxane resin select in case with polyorganosiloxane fluid in prevailing organic group be complementary.In the formula of preferred polyorganosiloxane resin at least 1/3, more preferably whole substantially R groups is methyl.Preferred R ₃SiO _1/2The siloxane unit example comprises Me ₃SiO _1/2And PhMe ₂SiO _1/2And Ph ₂MeSiO _1/2, Me represent methylidene wherein, and Ph represents phenyl.

Preferred R ₃SiO _1/2Siloxane unit and SiO _4/2Unitary mol ratio is respectively 0.5-1.2.More preferably whole R ₃SiO _1/2Siloxane unit and SiO _4/2Unitary mol ratio is 0.6-0.8.

Can adopt method well known in the art to prepare polyorganosiloxane resin.Preferably adopt through US-A-3,627,851 (Brady) and US-A-3, the improved US-A-2 of 772,247 (Flannigan), the silica hydrosol end blocking method is prepared among 676,182 people such as () Daudt; Each patent is all in conjunction with in the present invention, with reference to wherein preparing the content that is applicable to the water solublity organopolysiloxane in the preforming monolayer pellet part of the present invention.The resin of gained need not further improvement, or can be through the trialkylsilkl end-blocking to reduce the content of silanol.Can adopt the method for knowing to finish, as by resin and chemical compound trimethylchloro-silicane oxygen alkane or hexamethyldisiloxane reaction.

The diorganopolysiloxaneand polymer that polyorganosiloxane fluid is preferably hydroxy-end capped.The repetitive of polyorganosiloxane fluid is R ₂SiO _2/2Siloxy units, wherein R be independently selected from above-mentioned polyorganosiloxane resin in identical alkyl and the halogenation group of definition.Polyorganosiloxane fluid generally can be made of homopolymer or copolymer, and perhaps it can be made of the mixture of two or more these base polymers.Polyorganosiloxane fluid can be liquid or natural gum under 25 ℃.On the preferred polyorganosiloxane fluid chain at least 50%, preferred at least 85% organic group is a methyl, and it can be distributed in the polyorganosiloxane fluid in every way.In addition, polyorganosiloxane fluid can include up to the siloxane branches position of about 10mol%.

The consumption of polyorganosiloxane resin preferably accounts for the 40-70 weight portion of preformed monolayer pellet part, and the consumption of polysiloxane fluid accounts for 30 to about 60 weight portions, and wherein total umber of polyorganosiloxane resin and liquid is 100 parts.The general preferred 50-60 weight portion that is about of the consumption of polyorganosiloxane resin, the consumption of polyorganosiloxane fluid correspondingly generally is about the 40-50 weight portion, and wherein total weight parts equals 100.Polyorganosiloxane resin and polyorganosiloxane fluid mixed together or condensation (condense) can be made preformed monolayer pellet part.With the method for polyorganosiloxane resin and the common condensation of polyorganosiloxane fluid is well known in the art.

The preferred polyorganosiloxane resin of one class constitutes polyorganosiloxane resin by the end capped polysilicate resin of trimethyl silyl as the resin copolymer by the benzene dissolubility, wherein contains the hydroxyl with silicon atom bonding, and substantially by formula R ¹ ₃SiO _1/2Shown three organic group siloxy units and formula SiO _4/2Shown four functional group siloxies constitute, and wherein the ratio of three organic group siloxies and four functional group siloxies is about 0.6-0.9, wherein R in the copolymer ¹Be any monovalent organic radical group, be independently selected from the alkyl that contains 1-6 carbon atom; And and constitute by end capped poly-diorganosiloxane liquid of silanol such as polydimethylsiloxane mixtures of liquids.US-A-2,736,721 people such as () Dexter and US-A-2, the part that proposes this resin or similar resin among 814,601 people such as () Currie is all in conjunction with in the present invention as a reference.

Another kind of suitable polyorganosiloxane resin sees US-A-2, and 857,356 (Goodwin, Jr.), it is in conjunction with in the present invention as a reference, or is similar to the resin that Goodwin proposes.US-A-2, disclose a kind of polysiloxanes in 857,356, it is made of following mixture of ingredients, these compositions comprise: (i) cohydrolysis product of hydrolyzable silane of trialkyl and alkyl silicate, and wherein this cohydrolysis product comprises a plurality of and hydroxyl silicon atom bonding; And the (ii) highly viscous organopolysiloxanes liquid of straight chain, wherein contain hydroxyl with silicon atom bonding.

Polyorganosiloxane resin (i) and polyorganosiloxane fluid (ii) can be randomly through the common condensations of certain step, as at CA-A-711, and the step of describing among 756 (Pail), this patent is in conjunction with in the present invention as a reference.In this condensation reaction, in the presence of the silanol condensation catalyst of catalytically effective amount, mix polyorganosiloxane resin (i) and polyorganosiloxane fluid (ii), for example under refluxad heat then and made polyorganosiloxane resin (i) and (ii) condensation of polyorganosiloxane fluid in 1-20 hour.The example of the poly-catalyst of silanol condensation has: the primary, the second month in a season and tertiary amine, the carboxylic acid of these amine, and quaternary ammonium salt.

Other classes of these compositionss see US-A-4,591,622 and 4,584,355 (people such as Blizzard), and US-A-4,585,836 (people such as Homan), and US-A-4,655,767 (people such as Woodard) are in conjunction with in the present invention as a reference.They generally by (i) polyorganosiloxane resin and (ii) the mixture of polyorganosiloxane fluid constitute, it can be through chemical treatment to reduce in the mixture content with the hydroxyl of silicon bonding.These compositions can be randomly according to the preceding method condensation, then through chemical treatment.

The polysiloxane polymer gel former should not obscured with polysiloxane rubber, and it is not suitable for these applications.The polysiloxane polymer gel former is non-filling usually, or implant content lower (being lower than 5%).On the contrary, polysiloxane rubber generally contains the 15-35% filler approximately.Generally do not need high-load filler in the polysiloxane polymer gel former; because high-load regular meeting causes polysiloxane polymer gel former forfeiture adhesiveness and cohesive; and can increase its dynamic viscosity, it is more difficult that order coating organopolysiloxane gel forms the agent coating.

The polysiloxane polymer gel former that other classes are suitable for is found in FR-A-2 735 024 and EP-A-0 764 441, all in conjunction with in the present invention as a reference.

Another kind of non-soluble polymer gel former can be thermoplastic elastomeric block copolymers such as ABA block copolymer, as styrene-alkene-styrene block copolymer or Ethylene-Propylene Block Copolymer.More preferably this base polymer comprises the styrene/ethylene-butylene/styrene (SEBS) of hydrogenation grade, styrene/isoprene/styrene (SIS), and styrene/ethylene-propylene/styrene (SEPS).The water-soluble polymer gel former

Be applicable to that water-soluble polymer gel former of the present invention can be selected from synthetic or natural polymer, and composition thereof.The content of water-soluble polymer gel former generally is lower than 50% of gross weight in the preformed pellet part of the present invention, more preferably less than 30%, and particularly is lower than 20%.

Synthetic polymer: the synthetic polymer that is applicable to this comprises non-ionic water-soluble polymer; Based on polymerizing acrylic acid thing or derivatives thereof; Or cellulose derivative; And their mixture.Can be electrically charged or constitute monomer and classify according to its institute to the synthetic polymer that is applicable to this.But the classification that is understood that here to be done only for simplicity, exists overlapping between each classification.

Non-ionic water-soluble polymer: the non-ionic water-soluble polymer that is applicable to this comprises: polydimethylacrylamiin, polyvinyl pyrrolidone, polyethylene glycol monomethacrylate, poly--the 2-ethyl-2-oxazoline, polyvinyl alcohol, polyoxyethylene, polyvingl ether, the copolymer of polyvingl ether and polyvinyl pyrrolidone and derivant thereof, methyl vinyl ether and maleic anhydride, the copolymer of ethylene and maleic anhydride, and composition thereof.Non-cross-linked polymer comprises derived from following repetitive: vinyl alcohol, vinyl ethers and copolymer thereof, carboxy vinyl monomer, vinyl ester monomers, the monomeric ester of carboxy vinyl, vinylamide monomers, hydroxyl vinyl monomer, the cationic vinyl monomer that contains amine or quaternary ammonium group, N-vinyl lactam monomer and sulfonated polymer such as acrylamide sulfonated polymer and composition thereof.Perhaps this non-cross-linked polymer can be the homopolymer or the copolymer of polyvinylether, or derived from the copolymer of maleate half ester.Similarly any other compatible polymers monomeric unit also can be used as copolymer, for example polyvinyl alcohol and polyacrylic acid, or ethylene and vinyl-acetic ester.

Based on polymerizing acrylic acid thing or derivatives thereof: suitable comprises acrylate copolymer based on polymerizing acrylic acid thing or derivatives thereof, hydroxyethyl meth acrylate, the methacrylate of the methacrylate of methoxyl group diethoxy ethyl and hydroxyl diethoxy ethyl; Polyacrylate such as ammonium polyacrylate and sodium polyacrylate; The polymer of 2-acrylamido-2-methyl propane sulfonic acid or its salt (AMPS); Acrylamide and N, the copolymer of N '-methylene diacrylamine; And polyacrylamide or their mixture.

Other are applicable to that this polymer comprises the copolymer (" HEMA ") based on the 2-hydroxyethyl meth acrylate, comprising " HEMA " copolymer with one or more comonomers formation, see US-A-5,804,107 the 14th hurdle 36-67 are capable and the 15th hurdle 1-34 is capable; All in conjunction with in the present invention as a reference.

Cellulose derivative: the example that is applicable to this cellulose derivative comprises: carboxymethyl hydroxyethyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, acetic acid propanoic acid carboxylic acid cellulose, hydroxyethyl-cellulose, hydroxyethyl ethylcellulose, hydroxypropyl cellulose, methylcellulose, sodium carboxymethylcellulose pyce, hydroxypropyl emthylcellulose, methyl hydroxyethylcellulose, microcrystalline Cellulose, cellulose sodium sulfate, and composition thereof.Be applicable to this cellulose that replaces through alkyl that also has.In these polymer, the hydroxyl of cellulosic polymer forms the hydroxyalkylation cellulose through hydroxyalkylation (preferably through hydroxyethylation or hydroxypropylation), and it can be through the C by the ehter bond connection ₁₀-C ₃₀The further modification of straight or branched alkyl.These polymer generally are C ₁₀-C ₃₀The ether that straight or branched alcohol and hydroxy alkyl cellulose form.The example that is applicable to this alkyl is selected from: stearyl, iso stearyl, lauryl, myristyl, cetyl, different cetyl, the cocoyl alkyl of cocoanut oil alcohol (promptly derived from), palmityl, oil base, inferior oil base, Caulis et Folium Lini base, castor oil-base, docosyl, and composition thereof.Preferable material is the composition of CTFA called after cetyl hydroxyethyl-cellulose in the alkyl-hydroxyalkylcelluloswith ether, and it is the ether that spermol and hydroxyethyl-cellulose form.This material is sold with trade (brand) name Natrosol  CS Plus by Aqualon company.

Natural polymer: the natural polymer that is applicable to this comprises gelatin, polysaccharide, and composition thereof.The polysaccharide that is applicable to this is preferably selected from: red seaweed polysaccharide; Glucomannan; Galactomannan; The fermentation polysaccharide, or derivatives thereof; Fucoidin; The invertebrates extract is given birth in the sea; Starch, or derivatives thereof; The natural fruits extract; Plant fiber's derivant; Macrocystis pyrifera (L.) Ag.; The natural plants exudate; Resin glue (resinous gums); And composition thereof.When containing one or more as the polysaccharide of water-soluble polymer gel former in the device of the present invention, the content of polysaccharide or its mixture (with dry weight basis) is lower than 10% in the device, preferably is lower than 5%, more preferably less than 3%.

Gelatin: when adopting gelatin in the device,, be used to control dissolubility with the use that combines with low molecule gelatin of macromolecule gelatin.Molecular weight be low to moderate 20,000 or lower its gelling of gelatin poor.

Fucoidin: the polysaccharide that is categorized as fucoidin be subordinated in the various thalassophytes of Phaeophyceae (Phaebophyceae) class isolated.The fucoidin that is applicable to this comprise alginate jelly, alginic acid, ammonium alginate, calcium alginate, potassium alginate, sodium alginate, propylene glycol alginate, and composition thereof.

Red seaweed polysaccharide: the polysaccharide that is categorized as red seaweed polysaccharide be subordinated in the marine plant species of Rhodophyceae class isolated.Red seaweed polysaccharide can make aqueous gel have mechanical strength.Be applicable to that red seaweed polysaccharide of the present invention comprises: agar, the trademark naming of (CTFA) is an agar block on industry, it is derived from various Gelidium plants or close red algae platymiscium, can title " agar 100 " or " agar 150 " be purchased (Belcamp from TIC Gums, MD, USA), or with " agar K-100 " available from GumixInternational Inc. (Fort Lee, NJ, USA); Agarose, can title " SeaPlaque  " be purchased from FMC (Philadelphia, PA, USA) and with " agarose Type1-b " be purchased from Sigma-Aldrich Co.Ltd. (Poole, UK); Carrageenin, comprise λ-, ι-and κ-part, it is the water extract that is obtained by multiple China fir algae section or red tail feather dish section plant, the trademark naming of (CTFA) is a chondrus ocellatus Holmes on industry, can title " Gelcarin  LA ", " Seakem  3/LCM " or " Viscarin  XLV " available from FMC (Philadelphia, PA, USA); And danish agar, available from Gum TechnologyCorporation (Tucson, Arizona, USA) and Continental Colloids Inc. (Chicago, IL, USA), or the mixture of above component.The red seaweed polysaccharide that is applicable to this is preferably selected from agar, agarose, kappa carrageenan and danish agar, or their mixture.

Glucomannan: glucomannan is to contain basic polysaccharide for the mannose of straight chain or glucose residue main chain.Glucomannan comprises the short-chain branch that links to each other with linear backbone, and can there be the random existence of acetyl group the C-6 position of sugar unit.Have 1 acetyl group substituent group on general every 6-20 the sugar unit.Be applicable to that the ratio of mannose and glucose is about 0.2 to about 3 in this glucomannan or derivatives thereof.The glucomannan that preferably is applicable to this comprises Rheolex RX-L, and it is the adopted name of the powder class that obtains through Yan Mo Rhizoma amorphophalli (Rhizoma Dioscoreae) tuber, can trade name " Nutricol  Rhizoma amorphophalli powder " available from FMC (Philadelphia, PA, USA); With the deacetylate Rheolex RX-L; Or their mixture.

Galactomannan: galactomannan is the polysaccharide of plant origin, and it is present in the albuminous cell of multiple leguminous seeds.Collective term " galactomannan " comprises the polysaccharide that all are made of galactose and mannose residue.Galactomannan contains (1,4)-continuous β-unitary linear backbone of D-mannopyranose base.For the ring side group of being with, it is by the isolated galactopyranose residue of ∝-(1,6)-glycosidic bond.Galactomannan also can contain a spot of other saccharide residues.The galactomannan that is applicable to this has Semen Trigonellae natural gum; Herba Medicaginis; Semen astragali sinici; Tracasol (the commodity called after tragon of (CTFA) on industry), can title " Seagul L " available from FMC (Philadelphia, PA, USA); Tara gum, can available from Starlight Products (Rouen, France) or Bunge Foods (Atlanta, GA, USA); Guar gum derived from the grinding endosperm of Cyamopsistetragonolobus, can title " Burtonite V7E " available from TIC Gums (Belcamp, MD, USA), with " Jaguar C " available from Rhone-Poulenc (Marietta, GA, USA), or with " Supercol " available from Aqualon (Wilmington, DE, USA); And available from Starlight Products (Rouen, cassia gum France), or their mixture.The galactomannan preferred average 1 that is applicable to this to about 5 mannose group unit by one (1,6)-link to each other-∝ c-D-galactopyranose base unit replaces, and is selected from guar gum, tracasol and cassia gum, or their mixture.

Fermentation polysaccharide or derivatives thereof: the fermentation polysaccharide is a polysaccharide commercially available, that obtain through microbial fermentation in the culture medium of carbon containing and nitrogenous source, buffer agent and trace element.Be applicable to that fermentation polysaccharide or derivatives thereof of the present invention comprises Gellan gum, the commodity called after Gellan gum of (CTFA) on industry, be the macromolecule heteropolysaccharide glue that sugar is made through the pure culture fermentation with many natural ponds Rhodopseudomonas, can title " Kelcogel " available from Kelco (San Diego, CA, USA); Xanthan gum is a kind of macromolecule heteropolysaccharide glue that sugar is made through the pure culture fermentation with xanthomonas campestris, the commodity called after xanthan gum of (CTFA) on the industry, for example can title " Keltrol CG1000/BT/F/GM/RD/SF/T/TF " available from Calgon (Pittsburgh, PA, USA), or with " Kelzan " available from Kelco (San Diego, CA, USA); Natto gum; Pullulan; Rhamsan gum (rhamsan gum); Curdlan; Succinoglycan; Welan glue; Dextran, can title " Sephadex G-25 " available from Pharmacia Fine Chemicals (Piscataway, NJ, USA), and their derivant; And sclerotium gum, can title " Amigel " available from Alban Muller International (Montreil, France), or their mixture.Preferred this fermentation polysaccharide or derivatives thereof is selected from: xanthan gum and Gellan gum, or their mixture.The polysaccharide or derivatives thereof that more preferably ferments is an xanthan gum.

The invertebrates extract is given birth in the sea: derived from the sea give birth to invertebrates particularly the outer first of these invertebratess polysaccharide mainly constitute by N-acetyl group-D-glycosamine residue.This saccharoidal example that is applicable to this comprises: chitosan, for example with title " Marine Dew " available from Ajinomoto (Teakneck, NJ, USA); And hydroxypropyl chitosan, for example with title " HPCH liquid " available from Ichimaru Pharcos (Yamagata Gun Gifu-Pref, Japan), and their derivant; Or their mixture.

The starch or derivatives thereof: starch is by two kinds of glucose polymers, amylose and amylopectins polysaccharide with various compositions of proportions.The material that is applicable to this comprises: starch; Amylopectin; And dextrin, its can title " Nadex 360 " available from National Starch (Bridgewater, NJ, USA), or their derivant; Or their mixture.

The natural fruits extract: the example that is applicable to this natural fruits extract comprises: pectin; And Radix Acaciae senegalis; Or their mixture.

Plant fiber's derivant: the Plant fiber's derivant that is applicable to this is a cellulose.

The natural plants exudate: the polysaccharide that is applicable to this that is obtained by the natural plants exudate comprises: karaya, Tragacanth, Radix Acaciae senegalis, tamarind gum, and ghatti gum, or their mixture.

Resin glue: the example that is applicable to this resin glue comprises: Lac, and it is that resin-like secretions by glue worm (Laccifer (Tachardia) lacca) obtains; Gum dammar (damar gum); Mactra sulcatria Deshayes crust glue (copal gum) and Colophonium; Or their mixture.

The mixture that contains the water-soluble polymer gel former in the preferred preformed monolayer pellet part of the present invention.This mixture is selected from one or more non-ionic water-soluble polymers; One or more are based on polymerizing acrylic acid thing or derivatives thereof; One or more polysaccharide; And their mixture.For example, the preferred water-soluble polymer gel formation of the present invention agent composition can comprise polysaccharide and non-ionic water-soluble polymer, maybe can comprise two kinds of polysaccharide.More preferably the water-soluble polymer gel former is a polysaccharide mixture, and wherein polysaccharide mixture contains: (1) at least a red seaweed polysaccharide; Fucoidin; Or their mixture; And (2) at least a fermentation polysaccharide; Galactomannan; Glucomannan; The natural plants exudate; Or natural fruits extract; And derivant or their mixture.Water-soluble polymer gel former in the device more preferably of the present invention is a polysaccharide mixture, wherein contains: (1) at least a red seaweed polysaccharide; (2) at least a fermentation polysaccharide; Glucomannan; Or galactomannan; And derivant or their mixture.

In preferred embodiments, water-soluble polymer gel former of the present invention is a polysaccharide mixture, wherein contains red seaweed polysaccharide and glucomannan, or galactomannan.Although there is no particular restriction in theory, it is believed that in these polysaccharide mixtures to add glucomannan or galactomannan can be augmented red seaweed polysaccharide, and help to improve the mechanical strength of the preformed monolayer pellet part of the present invention.In addition, for the viewpoint of improving mechanical performance and be preferably the low syneresis amount that reaches preforming monolayer pellet part, red seaweed polysaccharide is about 20: 1 to about 1: 5 with the ratio of glucomannan or galactomannan in the preferred polysaccharide mixture, is more preferably 5: 1 to about 1: 2.

When polymer gel formed agent from natural origin, above-mentioned syneresis to a certain degree all can take place in all these gels.Syneresis provides the mechanism of effective ingredient to the application site transmission.The liquid level that is exuded to continuous gel phase surface can spread rapidly, is convenient to make device to wear the time weak point.Preforming monolayer pellet part of the present invention is suitable for having low syneresis amount, and the moistening of preferred device sense of touch of the present invention.Too high syneresis amount can cause the invalid and shortage absorption affinity of product.

The inventor also finds, for making polysaccharide gel have required intensity and flexible mechanical performance, when the polysaccharide polymer gel former selected for intensity combined with the composition with plasticization, the total content of polysaccharide polymer gel former should reduce as far as possible and its mechanical strength and pliability do not had a negative impact.It is believed that and adopt the polysaccharide of low total content can obtain open gel structure, thereby other components in the initial gel can not be fixed in the gel network structure tightly, can freely spread.

Preformed monolayer pellet part of the present invention preferably has low syneresis amount, and sense of touch is moistening.As previously mentioned, syneresis to a certain degree all can take place in the device that comprises gel, and too high syneresis amount can cause product invalid and lack absorption affinity.Water

In the preferred embodiments of the invention, it is under the water miscible situation that at least a polymer gel forms agent, moisture in the preformed monolayer pellet part of the present invention.If exist, the total moisture content in the preformed monolayer pellet part of the present invention account for device weight 20% to about 99.5%, be preferably about 30% to about 95%, more preferably about 40% to about 85%.Egative film

Preformed monolayer pellet part of the present invention is from support, and need not to adopt gasket material (the being commonly referred to egative film) support or the reinforcement of isolation or non-isolation.If but adopted egative film, it could combine with the monolayer pellet part, and further support or invigoration effect can be provided.Preferred egative film is non-isolation.In addition, egative film is specially adapted to the bigger device of area among the present invention.If egative film is used to provide further support or invigoration effect, it should have enough compatibilitys with device of the present invention, thus not can with device generation slabbing.

Egative film can adopt various materials.It is suitable for having following characteristic: (i) the enough moistening intensity of application, (ii) enough pliabilities, (iii) enough resiliences and porous, (iv) enough hydrophilic, make gel mixture spread and to infiltrate in the egative film, (v), split to prevent genetic horizon with the abundant compatibility of polysaccharide mixture, (vi) enough transparencys or translucence, and (vii) Shi Yi size.

In addition, egative film also can be used as the structuring action face.If egative film is used as the structuring action face, then egative film preferably is easy to and device generation slabbing.

The example that meets the suitable egative film of above-mentioned one or more conditions comprises: fabric and non-woven material; Polymer sheet layer material such as shaping membrane; With egative film made of paper.Effective ingredient

As necessary component of the present invention, comprise at least a effective ingredient of safe and effective amount in the preforming monolayer pellet part of the present invention.Here the term of Cai Yonging " effective ingredient " is meant and is used for using the active component that the position provides beauty treatment and/or therapeutical effect.Comprise following each constituents in this range of definition of effective ingredient, and for example vitamin and wetting agent.

Here the term of Cai Yonging " safe and effective amount " the consumption height that is meant effective ingredient improves the symptom of being nursed or makes skin, hair or fingernail reach required beneficial effect to being enough to, be enough to avoid serious adverse but its consumption should be low to moderate, the ratio of its suitable effect and risk is in rational medical judgment scope.The size of the safe and effective amount of effective ingredient will according to concrete effective ingredient, its in skin or in hair and/or fingernail or the permeance property on it, user's age, user's health status, user's factors such as skin, hair or fingernail situation judge.

Effective ingredient comprises pharmaceutically useful salt, and term " pharmaceutically useful salt " is meant and is applicable to the customary salt that contacts with tissue that it does not have disadvantageous toxicity, zest, incompatibility, unstability, allergy etc.

Generally contain about 0.01% to about 60% at least a effective ingredient that accounts for device weight or their mixture in the preformed monolayer pellet part of the present invention, be preferably about 0.05%, most preferably be about 0.1% to about 20% to about 30%.

Can classify to the effective ingredient that is applicable to this according to the model of action of its beauty treatment or therapeutic effect or expection.But be understood that the effective ingredient that is applicable to this has more than one beauty treatment and therapeutic effect sometimes, or by more than one model of action generation effects.Classification of the present invention thus and is not that effective ingredient is defined in concrete application or listed purposes only for simplicity.Following effective ingredient is applicable to preforming monolayer pellet part of the present invention.

Anti-acne active ingredient: acne vulgaris can effectively be treated and prevent to anti-acne active ingredient, and it is the pilosebaceous unit chronic disease.Symptom comprises pilosebaceous unit organ inflammation, thereby causes damage, comprises pimple, pustule, and cyst, acne and serious cicatrix produce.Corynebacterium acnes belongs to and staphylococcus epidermidis belongs to the common meeting of antibacterial to exist in the pustule content.The anti-acne active ingredient that is suitable for comprises introduces the keratin agent described in this WO98/18444 for reference.Other active component that are suitable for comprise retinoid mixture such as tretinoin (for example, cis and/or trans retinoic acid) and derivant (for example, tretinoin esters) thereof; Retinol and ester thereof (for example, propanoic acid retinol ester, retinol acetate); Rosin acid, adapalene, tazarotene, allantoin, Aloe extract, arbietic acid and salt thereof, ASEBIOL (available from Laboratories Serobiologiques, is positioned at Somerville, NJ), azaleic acid, Berberis thunbergii DC (barberry) extract, Arctostaphylos ura-ursi extract, Rhizoma Belamcandae, benzoquinoline ketone, benzoyl peroxide, berberine, BIODERMINE (available from Sederma, is positioned at Brooklyn, NY), bioflavonoids as a class material, bisabolol, S-Carbocisteine, Radix Dauci Sativae extract, yaupon oil (cassin oil), the clove tree extract, citral, citronellal, climazole, COMPLETECH MBAC-OS (available from Lipo, is positioned at Paterson, NJ), CREMOGEN M82 is (available from Dragoco, be positioned at Totowa, NJ), Fructus Cucumidis sativi extract, dehydroacetic acid and salt thereof, dehydroepiandrosterone and sulfate-derivatives thereof, Dichlorobenzene base imidazoles diazacyclo pentane, d, l-valine and ester thereof, DMDM Hydantoin, erythromycin, aescinate grass alcohol (escinol), ethylhexyl list glycerin ether, 2-hydroxyl undecanoic acid ethyl ester, farnesol, farnesyl acetate, geraniol, trans-Geranylgeraniol, glabridin, gluconic acid, gluconolactone, single caprin, glycolic, grapefruit seed extract, gugu lipid, HEDERAGENIN (available from Maruzen, is positioned at Morristown, NJ), hesperetin, chamenol, lupulus extract, Foral, the 10-hydroxydecanoic acid, ichthyol, il-1-alpha-2 antagonists, KAPILARINE is (available from Greentech, be positioned at Saint Beauzire, France), ketoconazole, lactic acid, citronella oil, LOCHOCHALCONE LRl5 (available from Maruzen, is positioned at Morristown, NJ), linoleic acid, LIPACIDE C8C0 (available from Seppic, is positioned at Paris, France), lovastatin, 4-methoxyl group salicylic acid, metronidazole, minocycline, mukurossi, the chinaberry seed oil, nicotiamide, nicotinic acid and ester thereof, nisin, pantothenylol, 1-pentadecanol, Flos Rosae Multiflorae (peonia) extract, Folium Menthae extract, Herba Oenanthes Javanicae (phelladendron) extract, 2-phenyl-benzothiophene derivative, phloretin, PHLOROGINE is (available from Secma, be positioned at Pontrieux, France), phosphatidylcholine, protease, Quercitroside, Lignum pterocarpi indici extract, Herba Rosmarini Officinalis extract, rutin, sage extract, salicin, salicylic acid, serine, Radix Scutellariae extract, siber hegner extract, Siberia Herba Saxifragae extract, silicol, the lauryl sodium phosphate, the sulfo group acetamide, the SOPHORA extract is (available from Maruzen, be positioned at Morristown, NJ), sorbic acid, sulfur, sunder vati extract, tea tree oil, tetrahydrochysene rosin acid, threonine, Thymi Serpylli Herba extract, tioxolone, tocopherol and ester thereof, trehalose 6-undecylenate, 3-tridecylene-2-alcohol, triclosan, tropolone, UNITRIENOL T27 is (available from Unichem, be positioned at Chicago, IL), vitamin D3 and analog thereof, white thyme oil (white thyme oil), extract of willow bark, wogonin, ylang ylang oil, glyceric acid zinc (zinc glycerolate), zinc linoleate, zinc oxide, pyrithione zinc, zinc sulfate, zwitterionic surfactant (for example, cetyl dimethyl betaine) and composition thereof.Gentle skin agent

The example of the gentle skin agent that is suitable among the present invention comprises: mineral oil, vaseline, C ₇-C ₄₀Branched-chain hydrocarbons, C ₁-C ₃₀Carboxylic acid C ₁-C ₃₀Alcohol ester, C2-C30 dicarboxylic acids C ₁- _C30Alcohol ester, C ₁-C ₃₀The carboxylic acid monoglyceride, C ₁-C ₃₀Carboxylic acid two sweet esters, C ₁-C ₃₀The carboxylic acid triglyceride, C ₁-C ₃₀The carboxylic acid ethylene glycol ester, C ₁-C ₃₀Carboxylic acid ethylene glycol diester, C ₁-C ₃₀The carboxylic acid propylene glycol monoester, C ₁-C ₃₀The carboxylic acid propylene glycol diesters, C ₁-C ₃₀Carboxylic acid sugar monoesters and sugared polyester, for example, SEFA Oleum Gossypii semen acid esters (many oleic acids sucrose ester), polydialkysiloxane, poly-diaromatic siloxane, gather the alkaryl siloxanes, contain the cyclohexyl methyl polysiloxanes of 3-9 silicon atom, vegetable oil, hydrogenated vegetable oil, propylene glycol C4-C20 alkyl ether, two C8-C30 alkyl ethers, and their mixture.These compositions have more detailed description in WO98/18444, its combination in the present invention as a reference.

On-steroidal anti-inflammatory activity composition (NSAIDS): be applicable to that this NSAIDS and ester thereof see WO98/18444, in conjunction with in the present invention as a reference.The example of other nonsteroidal anti-inflammatories (NSAIDS) comprising: flufenamic acid; Pantothenylol and ether thereof and ester derivant, pantothenylol ether for example, triacetic acid pantothenylol ester; Pantothenic acid and salt thereof and ester derivant, particularly calcium pantothenate; Aloe, bisabolol, allantoin and Radix Glycyrrhizae section plant compound (the Glycyrrhiza glabra L. genus/kind), comprise glycyrrhetinic acid, glycyrrhizic acid, and derivant, for example stearic alcohol ester of salt such as ammonium glycyrrhizinate and ester such as glycyrrhetinic acid.

Local anesthetic: the example that is applicable to this local anesthetic has anaesthesine and marcaine.Other examples that are suitable for see WO98/18444, in conjunction with in the present invention as a reference.

Artificial tanning agent and promoter: the artificial tanning agent by increase in the skin melanin or by forming melanin increases in the skin outward appearance to help to simulate natural Exposure to Sunlight effect.The non-limiting example of artificial tanning agent and promoter: comprise tyrosine glucose ester and Acetyl Tyrosine, brasilin, caffeine, coffee bean extract, dna fragmentation, isobutyl methylxanthine, methylxanthine, PHOTOTAN (available from Laboratoires Serobiologiques, is positioned at Somerville, NJ), prostaglandin, tea extract, bitter edible plant alkali, UNIPERTAN P2002 and UNIPERTAN P27 (available from Unichem, are positioned at Chicago, IL); And their mixture.Other artificial tanning agents that are applicable to this are found in WO98/18444.

Antibacterial: the example that is applicable to this antibacterial comprises alcohol, benzoate, sorbic acid, and their mixture.

Antimicrobial and antifungal activity composition: propagation and the growth of can be effectively pre-bacteriological protection of antimicrobial and antifungal activity composition and fungus.The non-limiting example of antimicrobial and antifungal activity composition comprises: ketoconazole, the ciclopirox cholamine, benzoyl peroxide, tetracycline, Azelaic Acid and derivant thereof, ethyl acetate, alantolactone, isoalantolactone, Radix Arnebiae (Radix Lithospermi) extract (alaninin), Pimpinella anisum Linn., arnica montana extract (helenalin acetas and 11,13 dihydro helenalins), the bracken extract (contains phlorhizin, the extract of lucinol), Berberis thunbergii DC extract (berberine hydrochloride), baysweet extract, Cortex Myricae Rubrae extract (arbutin), benzalkonium chloride, benzethonium chloride, benzoic acid and salt thereof, Benzoinum, benzylalcohol, blessing Ji grass, Pseudobulbus Bletillae (Rhizoma Bletillae) tuber, red root, bois de rose oil, Fructus Arctii, butyl p-hydroxybenzoate, cade oil, CAE (available from Ajinomoto, is positioned at Teaneck, NJ), cajaput (cajeput) oil, Rhizoma Atractylodis, caraway oil, card Herba chenopodii bark (selling) with trade name ESSENTIAL OIL, Cedar leaf oil, Chamomile, chaparral, chlorphenesin, chloroxylenol, Oleum Cinnamomi, citronella oil, cloves oil, dehydroacetic acid and salt thereof, dill seed oil, DOWICIL 200 (available from DowChemical, is positioned at Midland, MI), Echinacea, Fructus oleae europaeae acid, Epimedium, ethylparaben, FO-TI, galbanum, Radix Sanguisorbae, GERMALL 115 and GERMALL II are (available from ISP-Sutton Labs, be positioned at Wayne, NJ), German chamomile oil, Rhizoma Polygoni Cuspidati (giantknotweed), GLYDANT and GLYDANT PLUS (available from Lonza, are positioned at Fairlawn, NJ), grapefruit seed oil, two isethionic acid hexamidines, chamenol, Mel, Folium Rhododendri Simsii, lupulus, amaranth, IODOPROPYNL BUTYL CARBAMIDE is (available from Lonza, be positioned at Fairlawn, NJ), p-Hydroxybenzoic acid isobutyl ester, p-Hydroxybenzoic acid isopropyl ester, JM ACTICARE is (available from Microbial Systems International, be positioned at Nottingham, UK), juniper berries, KATHON CG is (available from Rohm and Haas, be positioned at Philadelphia, PA, USA), labdanum, Garden lavender, melissa oil, Herba Cymbopogonis Citrari, methyl parahydroxybenzoate, Herba Menthae, mume, mustard, Myrrha, the chinaberry seed oil, o-phenyl phenol, OLIVE LEAF extract is (available from Bio Botanica, be positioned at Hauppauge, NY), parsley, patchouli oil, root of Paeonia suffruticosa Ardr., PHENONIP (available from NipaLabs, is positioned at Wilmington, DE), phytosphingosine, pinke needle oil, PLANSERVATIVE (available from Campo Research, is positioned at Raffles Quay, Singapore), propyl p-hydroxybenzoate, Herba Portulacae, Quillaia saponaria, Radix Et Rhizoma Rhei, pelargonium roseum oil, Herba Rosmarini Officinalis, Salvia japonica Thunb., salicylic acid, yellow Camphor tree, savoury, river Radix Angelicae Sinensis, sodium metabisulfite, sodium sulfite, SOPHOLIANCE (available from Soliance, is positioned at Compiegne, France), sorbic acid and salt thereof, sphingol, Folium Stevlae Rebaudianae (stevia), styrax, tannic acid, the bitter edible plant, bitter edible plant tree oil (cajuput oil), Herba thymi vulgaris, triclosan, triclocarban, tropolone, Colophonium, umbelliferone (antifungal), and Y. flaccida Haw., or their mixture.Be applicable to that this antimicrobial and other examples of antifungal activity composition are found in this reference substance of introducing WO98/18444.

The skin soothing agent: the skin soothing agent can effectively prevent or treat scytitis.The skin soothing agent can promote skin appearance effect of the present invention, and for example, these compositions help skin gloss and color more all even pleasant.The non-limiting example of skin soothing agent comprises: Artemisia absinihium L, arabic gum, esculetin, the alder buckthornalder dogwood extract, allantoin, Aloe, APT (available from Centerchem, is positioned at Stamford, CT), Arnica, Astragalus, astragalus root extract, azulene, BAICALIN SR 15 (available from Barnet Products Dist., is positioned at Englewood, NJ), Radix Scutellariae, the Rhizoma Atractylodis Macrocephalae, Canada balsam, bee pollen, BIOPHYTEX is (available from Laboratories Serobiologiques, be positioned at Somerville, NJ), bisabolol, Radix vernoniae asperae, Black Cohosh P.E, Radix Clematidis, the Radix Clematidis extract, Euphatorium Perfoliatum, borage, borage oil, borage seed oil, pinguinain, Flos Inulae, Flos Inulae extract, CANADIAN WILLOWBARK extract (available from Fytokem), candelilla wax, Rhizoma Atractylodis, the canola plant sterol, Fructus Capsici, carboxypeptidase, celery seed, the stem of celery extract, CENTAURIUM (available from Sederma, is positioned at Brooklyn, NY), the Centaurea cyanus extract, Flos Matricariae chamomillae, Chamomile, chamomile extract, chaparral, Herba Viticis Cannabifoliae, Herba Viticis Cannabifoliae extract, Herba stellariae mediae, chicory root, the chicory root extract, Chiretta, Radix Paeoniae Rubra, Aveeno Bath, comfrey, the comfrey extract, CROMIST CM GLUCAN is (available from Croda, be positioned at Parsippany, NJ), darutoside, dehurian angelica Radix Angelicae Sinensis, DEVIL ' S CLAW is (available from MMP, be positioned at Plainfield, NJ), divalent metal is (as magnesium, strontium, manganese), quackgrass, Lai wood, EASHAVE is (available from Pentapharm, be positioned at Basel, Switzerland), eleutherol, ELHIBIN is (available from Pentapharm, be positioned at Basel, Switzerland), ENTELINE 2 is (available from Secma, be positioned at Pontrieux, France), Herba Ephedrae, Herba Epimedii, esculiw, Radix Oenotherae erythrosepalae, Herba Euphrasiae Regelii, EXTRACT LE100 is (available from Sino Lion, be positioned at World TradeCentre, NY), Radix Saposhnikoviae, Radix Agrimoniae, ficin, Fructus Forsythiae, Ganoderma, Rhizoma Ligustici, GATULINE A is (available from Gattefosse, be positioned at Saint Priest, France), Radix Gentianae, the germanium extract, Semen Ginkgo, Ginkgo, Radix Ginseng extract, groundraspberry, the Ge Erge extract, gotu kola, grapefruit extract, guaiac, the guggal extract, helenalin ester, Flos Impatientis, Folium Rhododendri Simsii, the Herba lagopsis supinae extract, Aesculus chinensis Bunge, Herba Equiseti Arvinsis, Rhizoma Polygoni Cuspidati, Hypericum, ichthyol, amaranth, hippo, Semen Coicis, Fructus Jujubae, cola extract, LANACHRYS 28 is (available from Lana Tech, be positioned at Paris, France), Fructus Citri Limoniae oil, Fructus Forsythiae, licorice, A.acutiloba (Sieb.et Zucc.) Kitag, Fructus Ligustri Lucidi, the Radix Levistici Officinalis root, Luffa, Arillus Myristicae, Flos Magnoliae Liliflorae, Fructus Viticis extract, margasipidin, matricin, MICROAT IRC is (available from Nurture, be positioned at Missoula, MT), Herba Menthae, mistletoe, MODULENE is (available from Seporga, be positioned at Sophia Antipolis, France), Semen phaseoli radiati extract, Moschus, oat extract, Citrus, pantothenylol, papain, Cortex Moutan, root of Paeonia suffruticosa Ardr., PHYTOPLENOLIN is (available from Bio Botanica, be positioned at Hauppauge, NY), PREREGEN (available from Pentapharm, is positioned at Basel, Switzerland), Herba Portulacae, QUENCH T (available from Centerchem, is positioned at Stamford, CT), Quillaia, red Salvia japonica Thunb., Radix Rehmanniae, Radix Et Rhizoma Rhei, Herba Rosmarini Officinalis, rosmarinic acid, Lac regis apis, Folium Symplocoris Caudatae, rutin, sandalwood, Radix Notoginseng, Asparagus curillus, sabal, SENSILINE (available from Silab, is positioned at Brive, France), SIEGESBECKIA (available from Sederma, is positioned at Brooklyn, NY), the stearic alcohol ester of glycyrrhetinic acid, STIMUTEX (available from Pentapharm, is positioned at Basel, Switzerland), styrax, birch oil, sweet Asperula orientalis, Tagetes, bitter edible plant extract, Thymi Serpylli Herba extract, tienchi Radix Ginseng, tocopherol, tocopherol acetate, triclosan, Rhizoma Curcumae Longae, urimei, maloic acid, the kahikatea skin, Radix Hamamelidis Mollis, Flos Magnoliae, achillea millefolium, yeast extract, Y. flaccida Haw., and their mixture.

Sunscreen: the example that is applicable to this sunscreen sees WO98/18444, in conjunction with in the present invention as a reference.The example that is applicable to this other sunscreen comprises: diethanolamine p-methoxycinnamic acid ester, dioxybenzone, ethyl dihydroxypropyl PABA, para-amino benzoic acid glyceride, lawsone (lawsome) and dihydroxyacetone, the ortho-aminobenzoic acid menthol ester, methyl 2-aminobenzoate, octyldimethyl PABA, red petroleum, sulisobenzone, triethanolamine salicylate, and their mixture.

Skin barrier repair aids: skin barrier repair aids is to help to repair and the skin protection auxiliary agent of the natural moisture preserving isolation features of additional epidermis.The non-limiting example of skin barrier repair aids comprises: brassicasterol, caffeine, campesterol; by the deutero-sterol of canola, CERAMAX (available from Quest, is positioned at Ashford; England), CERAMIDE HO3TM (available from Sederma, is positioned at Brooklyn; NY); CERAMIDE II and CERAMIDE 111 (available from Quest, are positioned at Ashford, England); CERAMIDE IIIB is (available from Cosmoferm; be positioned at Deift, Netherlands), CERAMIDE IS 3773 is (available from LaboratoriesSerobiologiques; be positioned at Somerville; NJ), CERAMINOL (available from Inocosm, is positioned at Chatenay Malabry; France); CERASOL and CEPHALIP (available from Pentapharm, are positioned at Basel, Switzerland); cholesterol; the hydroxy stearic acid cholesterol, isostearic acid cholesterol, 7-dehydrocholesterol; DERMATEIN BRC and DERMATEIN GSL are (available from Hormel; be positioned at Austin, MN), ELDEW CL 301 is (available from Ajinomoto; be positioned at Teaneck; NJ), ELDEW PS 203 (available from Ajinomoto, is positioned at Teaneck; NJ); FUFROBROSIDE (available from Pentapharm, is positioned at Basel, Switzerland); GENEROL122 is (available from Henkel; be positioned at Hoboken, NJ), the glyceryl serine amides; lactic acid; LACTOMIDE (available from Pentapharm, is positioned at Basel, Switzerland); lanoline; lanolin alcohol, lanosterol, lauric acid N-lauryl glucamide; thioctic acid; N-acetylcystein, serine, N-acetyl-L-serine; N-methyl-L-serine; NET STEROL-ISO (available from Barnet Products, is positioned at Englewood, NJ); nicotiamide; nicotinic acid and ester thereof, nicotinyl alcohol, Palmic acid; pantothenylol; pantethine (panthetine), phosphodiesterase inhibitor, PHYTO/CER is (available from Intergen; be positioned at Purchaser; NY), PHYTOGLYCOLIPIDMILLET EXTRACT (available from Barnet Products Distributer, is positioned at Englewood; NJ); PHYTOSPHINGOSINE (available from Gist Brocades, is positioned at Kingof Prussia, PA); PSENDOFILAGGRIN is (available from Brooks Industries; be positioned at South Plainfield, NJ), QUESTAMIDE H is (available from Quest; be positioned at Ashford; England), serine, stigmasterol; sitosterol; stigmastanol, the soy-derived sterol that obtains, sphingol; s-lactyl glutathion; stearic acid, SUPER STEROL ESTERS (available from Croda, is positioned at Parsippany; NJ); thioctic acid, THSC CERAMIDE OIL (available from CampoResearch, is positioned at Raffles Quay; Singapore); trimethyl glycerol, nicotinic acid tocopherol, vitamin D3 and analog thereof; or derivatives thereof; and Y2 (available from Ocean Pharmaceutical), or their mixture.

Crease-resistant and anti-atrophoderma active component: but crease-resistant and anti-atrophoderma active component epidermis and/or skin corium effectively replenish or restore.These active component are generally by promoting or keeping the natural process of decortication and/or make up dermal matrix each component of layer (for example, collagen and glucosaminoglycan) required skin effect is provided.The non-limiting example of crease-resistant and anti-atrophoderma active component comprises: nicotinic acid and ester thereof, nicotinyl alcohol, estrogen and estrogens compounds, or their mixture.Other are applicable to that this crease-resistant and anti-atrophoderma active component sees this WO98/18444 for reference of introducing.

Skin repair actives: skin repair actives can effectively be repaired epidermis and/or skin corium.The non-limiting example of skin repair actives comprises: acetin (actein), 27-deoxidation acetin cimicifugoside (cimigoside), adapalene; tazarotene, ademetionine, adenosine; the alertris spicata extract, derived from aloetic agglutinin, 3-aminopropyl dihydrogen orthophosphate; AMADORINE (available from Barnet Products, is positioned at Englewood, NJ); the Pimpinella anisum Linn. extract, AOSINE (available from Secma, is positioned at Pontrieux; France), the arginine amino benzoic Acid, ASC III is (available from E.Merck; be positioned at Darmstadt, Germany), ascorbic acid and derivant thereof; ascorbyl palmitate, Ya Xiya acid, asiaticoside; ARLAMOLGEO (available from ICI, is positioned at Wilmington, DE); Azelaic Acid, benzoic acid derivative, brazilnut extract; belulinic acid Betulinic acid, BIOCHANIN A, BIOPEPTIDE CL and BIOPEPTIDE EL are (available from Sederma; be positioned at Brooklyn, NY), biotin; the blackberry bark extract, Rhizoma Belamcandae extract, Black Cohosh P.E; the Radix Clematidis extract, bytyry belulinic acid Betulinic acid, youngster's naphthol amine; chalcone derivative, Herba Viticis Cannabifoliae extract, cis-retinoic acid; citrate, Herba Trifolii Pratentis extract, coenzyme Q10 (ubiquinone); coumestrol; (Barnet Products is positioned at Englewood, NJ) to CPC PEPTIDE; daidzein; Radix Angelicae Sinensis extract, darutoside, debrominate laurinferol (debromo laurinterol); 1-capryl-glycerol-phosphonic acids; dehydrocholesterol, dehydrogenation xylenol, dehydrogenation two acetaminol; dehydroepiandrosterone; DERMOLECTINE (available from Sederma, is positioned at Brooklyn, NY); hydroascorbic acid and derivant thereof; the dehydroepiandrosterone sulfuric ester, two anethole, 2; the 4-resorcylic acid; diosgenin, ascorbyl disodium hydrogen phosphate, dodecanedioic acid; EDERLINE is (available from Seporga; be positioned at Sophia Antipolis, France), ELESERYL SH is (available from Laboratories Serobiologiques; be positioned at Somerville; NJ), ENDONUCLEINE (available from Laboratories Serobiologiques, is positioned at Somerville; NJ); equol (equol), ergosterol, eriodictyol; estrogen and derivant thereof; ethocyn, eythrobic acid, farnesol; farnesyl acetate; Fructus Foeniculi extract, FIBRASTIL (available from Sederma, is positioned at Brooklyn; NY); FIBROSTIMULINES S and P (available from Sederma, are positioned at Brooklyn, NY); FIRMOGENIS 8445 is (available from Laboratories Serobiologiques; be positioned at Somerville, NJ), flavonoid (particularly flavanone such as unsubstituted flavanone and chalcone derivative such as unsubstituted chalcone derivative and monohydroxy and dihydroxy chalcone derivative); formononetin (formononetin); the Fructus Forsythiae berry extract, epicatechol gallate, γ-An Jidingsuan; GATULINE RC is (available from Gattlefosse; be positioned at SaintPriest, France), genistein; genisteine; the dyestuff wood acid, sateripol, Semen Ginkgo extrac; Radix Ginseng extract; the ginsenoside, RO, R _6-1, R _6-2, R _6-3, R _c, R _D, R _E, R _F, R _F-2, R _G-1, R _G-2, glucose pyrans glycosyl-1-acid ascorbyl ester, glutathion and ester thereof, Glycitein (glycitein); eptyloxy 4 salicylic acid, hesperetin, six hydrogen Rhizoma Curcumae Longaes, HMG-CoA-reductase inhibitors; the lupulus extract, 11-hydroxyl undecanoic acid, 10-hydroxydecanoic acid; the 25-hydroxycholesterol oxycholesterol, ISOFAVONE SG 10 (available from Barnet Products, is positioned at Englewood; NJ), kinetins, 1-2-oxygen Thiazolidine-4-carboxylate; the lactate dehydrogenase inhibitor, 1-lauryl ,-LYSO-PHOSPHATIDYLCHOLINE LYSOPC; agglutinin, LICHOCHALCONE LR15 (available from Maruzen, is positioned at Morristown; NJ), Radix Glycyrrhizae extract, thioctic acid; lumisterol, luteolin, ascorbyl magnesium phosphate; melatonin, 6-(.alpha.-D-galactosido)-D-glucose., inhibitors of metalloproteinase; methoprene, methoprenicacid, 4-methoxyl group salicylic acid; mevalonic acid, MPC COMPLEX (available from CLR, is positioned at Berlin; Germany), N-acetylcysteine, N-methyl serine; N methyl taurine, N, N ¹-two (lactyl) mercaptamine, naringenin, new tigogenin; the 5-MEXORYL SAM, the nor-angiotensin of 0-, oleanolic acid; pantethine, phenylalanine, light fenchone (photoanethone); phytic acid and salt thereof, piperidines, intacellin; pratensein, pregnenolone, acetic acid pregnenolone; the succinic acid pregnenolone, premarin, quillaic acid; raloxifene, REPAIR FACTOR 1 (available from Sederma, is positioned at Brooklyn; NY), REPAIRFACTOR SPC (available from Sederma, is positioned at Brooklyn; NY), axerophthal, retinoic acid ester (C2-C20 alcohol ester); retinol, retinol acetate, glucuronic acid retinol ester; the linoleic acid retinol ester, retinyl palmitate, propanoic acid retinol ester; REVITALIN BT (available from Pentapharm, is positioned at Basel, Switzerland); the S-Carbocisteine, salicylic acid, SEANAMINE FP is (available from Laboratories Serobiologiques; be positioned at Somerville; NJ), sodium ascorbyl phosphate, soybean extract; spleen extract; tachysterol, taurine, tazarotene; thymulen; thymic extract, thyroxin, tigogenin; the tretinoin tocopherol; toxifolin, trans retinoic acid, 1-decene-1; citric acid three choline; trifoside, uracil derivative, maloic acid; vitamin D3 and analog thereof; vitamin K, Herba Viticis Cannabifoliae extract, Rhizoma Dioscoreae extract; yamogenin, and zeatin (zeatin) or their mixture.

Lipid: the embodiment of this suitable class comprises: castor oil acid spermaceti alcohol ester, hydroxy stearic acid cholesterol ester, isostearic acid cholesterol ester, CREMEROL (available from Amerchol, is positioned at Edison, NJ), ELDEW C1301 is (available from Ajinomoto, be positioned at Teaneck, NJ), lanoline, MODULAN is (available from Amerchol, be positioned at Edison, NJ), OHLAN is (available from Amerchol, be positioned at Edison, NJ), vaseline, phytantriol, with SUPER STEROL ESTERS (available from Croda, be positioned at Parsippany, NJ), or their mixture.

Skin whitener: skin whitener is usually used in reducing melanic content in the skin, or reaches this effect by other mechanism.The skin whitener that is applicable to this sees EP-A-758, and 882 and EP-A-748,307, all in conjunction with in the present invention as a reference.Other examples of skin whitener comprise: adapalene, Aloe extract, amino tyrosine; DL-Lactic acid ammonium salt., anethole derivant, Fructus Mali pumilae extract; arbutin, ascorbic acid and derivant thereof, Palmic acid ascorbyl ester; Azelaic Acid, bamboo extractive, Arctostaphylos ura-ursi extract; the Pseudobulbus Bletillae (Rhizoma Bletillae) tuber; Radix Bupleuri extract, Radix Sangusorbae extract, BURNETPOWDER is (available from Barnet Products; be positioned at Englewood; NJ), Butylated hydroxyanisole, butylated hydroxytoluene; Rhizoma Chuanxiong; Radix Angelicae Sinensis, deoxyarbutin, 1; the 3-diphenyl propane derivative; 2,5 resorcylic acids and derivant thereof, 2-(4-acetoxyl group phenyl)-1; 3-Di Sen; 2-(4-hydroxyphenyl)-1,3-Di Sen, ellagic acid; aescinate grass alcohol (escinol); the estragole derivant, esculiw, esculetin; FADEOUT is (available from Pentapharm; be positioned at Basel, Switzerland), Radix Saposhnikoviae; Fructus Foeniculi extract; gallic acid and derivant thereof, Ganoderma extract, Rhizoma Ligustici; GATULINEWHITENING is (available from Gattefosse; be positioned at Saint Priest, France), dyestuff wood acid and derivant thereof; sateripol; glabridin and derivant thereof, glycopyranosyl-1-acid ascorbyl ester, gluconic acid; glycosamine; glycolic, glycyrrhizic acid, green tea extract; 4-hydroxy-5-methyl base-3[2h]-furanone; hydroquinine, 4-BHA and derivant thereof, 4-hydroxybenzoic acid derivative; Hydroxycaprylic acid; the ascorbic acid mesoinositol, kojic acid, lactic acid; citron extract; Radix Glycyrrhizae extract, LICORICE P-TH (available from Barnet Products, is positioned at Englewood; NJ); linoleic acid, the ascorbyl magnesium phosphate, MELFADE is (available from Pentapharm; be positioned at Basel; Switzerland), MELAWHITE (available from Pentapharm, is positioned at Basel; Switzerland); mulberry extract, mulberry root extract, nicotiamide; nicotinic acid and ester thereof; nicotinyl alcohol, 5-MEXORYL SAM, parsley extract; phellinus linteus extract; intacellin, pyrogaelol derivant, tretinoin; retinol; retinol ester (acetas, propionic ester, cetylate; linoleate); 2,4-resorcinol derivant, 3; the 5-resorcinol derivatives; rose fruit extract, rucinol, salicylic acid; pine clothing extract; SOPHORA POWDER (available from BarnetProducts, is positioned at Englewood, NJ); 4-thioresorcin (4-thioresorein); 3,4,5-trihydroxy benzyl derivative; tranexamic acid; TYROSLAT 10,11 (available from Fytokem), vitamin D3 and analog thereof; yeast extract, or their mixture.

Sebum inhibitor: sebum inhibitor can reduce the generation of sebum in the sebaceous gland.The example of the sebum inhibitor that is suitable for comprises: aluminium chlorhydroxide, and ASEBIOL (available from LaboratoriesSerobiologiques, is positioned at Somerville, NJ), BIODERMINE (available from Sederma, is positioned at Brooklyn, NY), climbazole, COMPLETECH MBAC-OS is (available from Lipo, be positioned at Peterson, NJ), corticosteroid, Fructus Cucumidis sativi extract, dehydroacetic acid and salt thereof, Dichlorobenzene base imidazoles diazacyclo pentane, ketoconazole, LICHOCHALCONE LR 15 (available from Maruzen), nicotiamide, nicotinic acid and ester thereof, nicotinyl alcohol, phloretin, PHLOROGINE (available from Secma, is positioned at Pontrieux, France), Benadon and derivant thereof, the S-Carbocisteine, SEPICONTROL AS, spironolactone, tioxolone, tocopherol, UNITRIENOL T27 (, being positioned at Chicago IL) available from Unichem, and ZINCIDONE is (available from UCIB, be positioned at Clifton, NJ), or their mixture.

The sebum stimulant: the sebum stimulant can increase sebaceous gland and produce sebum.The non-limiting example of sebum stimulant comprises: bryonolic acid (bryonolic acid), COMPLETECH MBAC-DS (available from Lipo, be positioned at Paterson, NJ), dehydroepiandrosterone (being also referred to as DHEA), orizanol, and their mixture.

The skin sensitizer: the non-limiting example that is applicable to this skin sensitizer comprises the composition that cooling feeling can be provided, as: Camphora, thymol, 1-menthol and derivant thereof, Eucalyptus, Methanamide; Terpane ether and terpane ester; And the composition that warmth sensation can be provided, as capsicum tincture, Fructus Capsici extract, Fructus Capsici powder, n-nonanoic acid vanillyl amide, nicotinic acid derivates (benzyl nicotinate, methyl nicotinate, nicotinic acid phenylester etc.), capsaicin, Nasturtium officinale extract, Pericarpium Zanthoxyli extract and Rhizoma Zingiberis Recens extract, or their mixture.

Protease inhibitor: but protease inhibitor is the chemical compound of Profilin hydrolytic process (being that protein resolves into low peptide moiety and amino acid whose process).The example of useful proteases inhibitor comprises: A E COMPLEX is (available from Barnet Products, be positioned at Englewood, NJ), ALE is (available from Laboratoires Seporgia, be positioned at Sophia Antipolis, France), allicin, AOSAINE is (available from Secma Biotechnologies Marine, be positioned at Pontrieux, France), APROTININ is (available from Pentapharm AG, be positioned at Basel, Switzerland), Semen Arecae extract, BLUE ALGAE extract is (available from Collaborative Labs Inc., be positioned at East Setauket, NY), CENTAURIUM is (available from Sederma, be positioned at Brooklyn, NY), CMST (available from Bioetica Inc., is positioned at Portland, ME), DERMOPROTECTINE (available from Sederma, is positioned at Brooklyn, NY), DISACOSIDE HF 60 (is positioned at Englewood available from BarnetProducts, NJ), ELHIBIN (available from Pentapharm AG, is positioned at Basel, Switzerland), FLUID OUT COLLOID (available from Vegetech, is positioned at Glendale, CA), HYPOTAURINE is (available from Sogo Pharmaceutical Co.Ltd, be positioned at Chirodaku Tokyo), IN CYTE HEATHER (available from Collaborative LabsInc., is positioned at East Setauket, NY), MICROMEROL (available from CollaborativeLabs Inc., is positioned at East Setauket, NY), PEFABLOC SP is (available from PentapharmAG, be positioned at Basel, Switzerland), SEPICONTROL AS is (available from Seppic, be positioned at Paris, France), SIEGESBECKIA (available from Sederma, is positioned at Brooklyn, NY), SOPHORINE (available from Barnet Products, is positioned at Englewood, NJ), THIOTAINE is (available from Barnet Products, be positioned at Englewood, NJ), and their mixture.

The skin-tightening agent: the example of skin-tightening agent comprises: BIOCARE SA is (available from Amerchol, be positioned at Edison, NJ), ovalbumin, FLEXAN 130 (available from National Starch, is positioned at Bridgewater, NJ), GATULINE LIFTING is (available from Gattefosse, be positioned at Saint Priest, France), PENTACARE HP is (available from Pentapharm AG, be positioned at Basel, Switzerland), VEGESERYL (available from LaboratoriesSerobioloques, is positioned at Somerville, and their mixture NJ).

The antipruritic composition: the example of antipruritic composition comprises: STIMU TEX is (available from PentapharmAG, be positioned at Basel, Switzerland), TAKANAL is (available from Ikeda-Distributor, be positioned at Tokyo, Japan), ICHTHYOL is (available from InternationalSourcing-Distributor, be positioned at Upper Saddle River, NJ), OXYGENATEDGLYCERYL TRIESTERS (available from Laboratoires Seporgia, is positioned at SophiaAntipolis, and their mixture France).

Hair growth inhibitor: the example that is applicable to the composition of hair growth inhibition comprises: 17-β estradiol, adamantyguanidines, adamantylamidines, adenylosuccinic acid synthase inhibitor, the angiogenesis inhibitor steroid, aspartate transcarbamylase inhibitors, betamethasone valerate, bisabolol, copper ion, Rhizoma Curcumae Longae extract, cycloxygenase inhibitor, cysterne pathway inhibitor, dehydroacetic acid, dehydroepiandrosterone, Folium Kaki (diopyrosleak) extract, epidermal growth factor, table Gallate bitter edible plant element, the basis fatty acid, Radix Oenotherae erythrosepalae oil, gamma glutamyl transpeptidase inhibitor, oil of ginger, the glucose metabolism inhibitor, glu famine metabolic poison, glutathion, green tea extract, heparin, KAPILANNE (available from International SourcingDistributor, is positioned at Upper Saddle River, NJ), the L-5 diaminovaleric acid, L-asparagine synthase inhibitor, linoleic acid, lipoxidase inhibitor, the longa extract, Herba Mimosae Pudicae amine dihydrochloride, mimosine, inhibitors of nitric oxide synthase, nonsteroidal anti-inflammatory, ODC Ornithine decarboxylase inhibitor, ornithine base transaminase inhibitor, pantothenylol, phorhetur, phosphodiesterase inhibitor, Pleion plant extract, inhibitors of protein kinase C, the 5-alpha reductase inhibitor, sulfhydryl compound of reaction, tioxolone, transforming growth factor-1, urea, zinc ion, and their mixture.

The 5-alpha reductase inhibitor: the example of 5-alpha reductase inhibitor comprises: CLOVE 55 (available from Barnet Products Distributor, is positioned at Englewood, NJ), the male glycol of acetenyl, genisteine, genistin, Licochalcone LR-15, Saw Palmetto P.E, the SOPHORA extract is (available from Maruzen, be positioned at Morristown, NJ), ZINCIDONE (available from UCIB, is positioned at Clifton, and their mixture NJ).

Decortication enzyme promoter: these compositions can promote the activity of endogenous decortication enzyme.The non-limiting example of decortication enzyme promoter comprises: N-methyl serine, serine, trimethyl glycine, and their mixture.

Anti-gfycation agent: anti-gfycation agent (anti-glycation agent) can prevent the collagen cross-linking that sugar causes.The suitable examples of anti-gfycation agent comprises: AMADORINE (available from Barnet ProductsDistributor, is positioned at Englewood, NJ).

The effective ingredient that preferably is applicable to this comprises and is selected from those compositions of following group: ascorbic acid and derivant thereof, salicylic acid, nicotiamide, nicotinic acid tocopherol, benzoyl peroxide, 3-hydroxy benzoic acid, flavonoid (for example, flavanone, chalcone derivative), farnesol, phytantriol, glycolic, lactic acid, 4-hydroxy benzoic acid, aspirin, 2-hydroxybutyric acid, the 2-hydroxypentanoic acid, the 2-hydroxycaproic acid, cis-tretinoin, trans-tretinoin, retinol, retinol ester (for example, the propanoic acid retinol ester), phytic acid, N-acetyl-L-cysteine, thioctic acid, tocopherol and ester thereof (for example, tocopherol acetate), Azelaic Acid, arachidonic acid, tetracycline, ibuprofen, naproxen, ketoprofen, hydrocortisone, acetominophen, resorcinol, phenyl phenol, phenoxypropanol, phenoxy group isopropyl alcohol, 2,4,4 '-three chloro-2 '-xenol ether, 3,4,4 '-trichloro-symmetrical diphenyl urea, Octopirox, lidocaine hydrochloride, clotrimazole, miconazole, ketoconazole, polygynax, bitter edible plant alkali, and their mixture.

When being used for the beautifying nursing method of skin, hair or fingernail, the beauty treatment effective ingredient is preferably selected from: crease-resistant and anti-atrophoderma active component, anti-acne active ingredient, artificial tanning agent and promoter, gentle skin agent, wetting agent, skin repair actives, skin barrier repair aids, skin whitener, the skin sensitizer, skin soothing agent, lipid, sebum inhibitor, the sebum stimulant, sunscreen, protease inhibitor, the skin-tightening agent, antipruritic composition, and decortication enzyme promoter, or their mixture.Wetting agent

Preferred preformed monolayer pellet part contains at least a wetting agent.Can add wetting agent to reach plastic effect and to increase the moisturizing properties of preforming monolayer pellet part when being used for application surface.Some wetting agent such as hexanediol also can make preformed monolayer pellet part of the present invention have anti-microbial property and characteristic.In addition,, it is generally acknowledged, decompose thereby device is difficult under extreme temperature conditions by in preformed monolayer pellet part of the present invention, adding the stability that wetting agent can increase device although do not wish that any restriction is arranged in theory.Preformed monolayer pellet part of the present invention generally contains 1.0% to about 45% the wetting agent of having an appointment, and is preferably about 5% to about 40%, and more preferably from about 10% to about 30%.

Be applicable to that wetting agent of the present invention sees WO98/22085, WO98/18444 and WO97/01326 are all in conjunction with in the present invention as a reference.Other wetting agents that are suitable for comprise aminoacid and derivant thereof, as proline and arginine aspartate, l; the 3-butanediol, propylene glycol and water, and fine hair Korean pine (codium tomentosum) extract; collagen amino acid or peptide, kreatinin, diglycerol; biological carbohydrate gum-1, glucose ammonium salt, glucuronate; glutamate, Glu, glycerol polyethylene glycol ether (for example glycereth 20) glycerol, glycerol list propoxylate; glycogen, hexanediol, Mel and extract or derivatives thereof thereof; hydrogenated starch hydrolysates; the hydrolysis mucopolysaccharide, inositol, keratin aminoacid; LAREXA-200 (available from Larex); glucosaminoglycan, methoxyl group PEG 10, methyl gluceth-l0 and-20 is (all available from Amerchol; be positioned at Edison; NJ), methyl glucoside, 3-methyl isophthalic acid; the 3-butanediol; N-acetyl group glucose ammonium salt, pantothenylol, Polyethylene Glycol and derivant thereof are (as PEG 15 butanediols; PEG 4; PEG 5 tetramethylolmethanes, PEG 6, and PEG 8; PEG9); tetramethylolmethane, 1, the 2-pentanediol; PPG-1 glyceryl ether; PPG-9,2-Pyrrolidone-5-carboxylate and salt thereof is as glyceryl PCA; the sugar isomer; SEACARE (available from Secma), sericin, Silk Amino Acids; the acetyl group hyaluronate sodium; hyaluronate sodium, poly (sodium aspartate), polyglutamic acid sodium; polyoxyethylene sorbitan ester 20 (sorbeth 20); polyoxyethylene sorbitan ester 6, sugar and sugar alcohol and derivant thereof are as glucose; mannose and polyglycereol; sorbitol, trehalose, triglycerin; trimethylolpropane; three (methylol) aminomethane salt, and yeast extract, or their mixture.

The wetting agent that preferably is applicable to this is selected from: glycerol, butanediol, hexanediol, pantothenylol and Polyethylene Glycol and derivant thereof, or their mixture.Emulsifier/surfactant

Preformed monolayer pellet part of the present invention also can randomly contain one or more surfactants and/or emulsifying agent.Emulsifying agent and/or surfactant generally help in continuous phase to disperse with the suspension non-dispersive mutually.When product was skin, hair or nail cleansing product, surfactant also was suitable for.For simplicity, emulsifying agent is hereinafter also listed in term " surfactant " item down, and therefore " surfactant " is used for the various surfactants of expression as emulsifying agent or other surfactant purposes (as skin, hair or fingernail cleaning).Surfactant known and commonly used can be used for the present composition, if selected composition chemically and physically with the necessary component compatibility of the present composition, and can provide desired characteristic.The surfactant that is suitable for comprises silicone materials, non-silicone material, and their mixture.

Preferably contain have an appointment 0.01% to about 15% surfactant or its mixture in the present composition.Selection to concrete surfactant or surfactant mixture will be decided according to pH and existing other components of compositions.Preferred surfactants is a non-ionic surface active agent.

Be applicable to that wherein non-ionic surface active agent of the present invention is: the condensation product of oxyalkylene and fatty acid (being the oxyalkylene fatty acid ester).The general formula of this class material is: RCO (X) _nOH, wherein R is C _10-30Alkyl, X are-OCH ₂CH ₂-(promptly derived from ethylene glycol or oxygen ethylene), or-OCH ₂CHCH ₃-(promptly derived from propylene glycol or oxypropylene), and n is about 6 to about 100 integer.Other non-ionic surface active agents have the condensation substance (being oxyalkylene fatty acid diester) of oxyalkylene and 2mol fatty acid.The general formula of these materials is: RCO (X) _nOOCR, wherein R is C _10-30Alkyl, X are-OCH ₂CH ₂-, or-OCH ₂CHCH ₃-, and n is about 6 to about 200 integer.Other non-ionic surface active agents are polycondensation products (being the oxyalkylene fatty alcohol ether) of oxyalkylene and aliphatic alcohol.The general formula of this class material is R (X) _nOR ', wherein R is C _10-30Aliphatic group, X are-OCH ₂CH ₂-, or-OCH ₂CHCH ₃-, and n is about 6 to about 100 integer, and R ' is H or C _10-30Aliphatic group, the example comprise PEG 40 castor oil hydrogenated, can trade name " Cremophor RH 40 " available from BASF (Parsippany, NJ, USA); PEG 60 castor oil hydrogenated, can trade name " Cremophor RH 60 " available from BASF (Parsippany, NJ, USA); Different cetyl ether-20, can trade name " Arlasolve 200 " available from ICI (Wilmington, MA, USA); And oleyl ether-20, can trade name " VolpoN20 " available from Croda Chemicals Ltd. (Goole, North Humberside, England).Other non-ionic surface active agents are condensation products [promptly wherein polyoxyalkylene part one end is through fatty acid esterification, and the other end links to each other with aliphatic alcohol (promptly linking to each other by ehter bond)] of oxyalkylene and fatty acid and aliphatic alcohol.The general formula of this class material is: RCO (X) _nOR ', wherein R and R ' are C _10-30Alkyl, X are-OCH ₂CH ₂-, or-OCH ₂CHCH ₃-, and n is about 6 to about 100 integer, the example comprises: cetyl ether-6, cetyl ether-10, cetyl ether-12, cetearyl ether-6, cetearyl ether-10, cetearyl ether-12, stearyl ether-6, stearyl ether-10, stearyl ether-12, PEG-6 stearate, the PEG-10 stearate, the PEG-100 stearate, PEG-12 stearate, PEG-20 tristerin, PEG-80 tallow acid glyceride, the PEG-10 tristerin, PEG-30 glyceryl cocoate, PEG-80 glyceryl cocoate, PEG-200 tallow acid glyceride, the PEG-8 dilaurate, PEG-10 distearate, and their mixture.

Other are applicable to that this non-ionic surface active agent is alkyl polyglucoside and alkyl poly glucoside, and it more specifically sees WO98/18444, in conjunction with in the present invention as a reference.Other ionic surfactant pack that are suitable for are drawn together polyhydroxy fatty acid amide surfactants, and it more specifically is found in WO98/04241.

Other ionic surfactant pack that are applicable to this are drawn together: sugar ester and polyester, alkoxylate sugar ester and polyester, C ₁-C ₃₀The C of fatty acid ₁-C ₃₀Aliphatic alcohol ester, C ₁-C ₃₀The C of fatty acid ₁-C ₃₀The alkoxy derivative of aliphatic alcohol ester, C ₁-C ₃₀The alkoxylated ether of aliphatic alcohol, C ₁-C ₃₀The polyglycerin ester of fatty acid, polyhydric alcohol C ₁-C ₃₀Ester, polyhydric alcohol C ₁-C ₃₀Ether, alkyl phosphate, polyoxyalkylene aliphatic ether phosphate ester, fatty acid amide, acyl lactylates, and their mixture.These examples that do not contain the surfactant of poly-silicon comprise: polysorbate20, Polyethylene Glycol 5 soyasterols, stearyl ether-20, cetearyl ether-20, PPG-2 methyl glucose ether distearate, polysorbate80; Polysorbate60, can trade name " Tween 60 " available from ICI (Wilmington, MA, USA); Tristerin, Arlacel-20, polyoxyethylene-4-lauryl ether sodium stearate, polyglycereol-4-isostearate, lauric acid hexyl ester, PPG-2 methyl glucose ether distearate, and their mixture.

Preferred nonionic is selected from: cetearyl ether-12, coconut oil sucrose ester, stearyl ether-100, polysorbate60, PEG-60 castor oil hydrogenated, different cetyl ether-20, oleyl ether-20, PEG-100 stearate, and their mixture.

Other are applicable to that this emulsifying agent is a polyoxypropylene, fatty alcohol-polyoxyethylene ether.The general formula of these materials is: R (CH ₂CHCH ₃O) _x-(CH ₂CH ₂O) _y-H, wherein R is OC ₁₀-C ₃₀Alkyl or C ₁₀-C ₃₀Alkyl, the meansigma methods of x are 1-20, and the meansigma methods of y is 1-30, and the example comprises PPG-6-decyl myristyl ether-30, can trade name " Pen 4630 " available from Nikko Chemicals Co.Ltd. (Tokyo, Japan); PPG-6-decyl myristyl ether-20, can trade name " Pen4620 " available from Nikko Chemicals Co.Ltd. (Tokyo, Japan); And PPG-5 cetyl ether-20, can trade name " Procetyl AWS " available from Croda ChemicalsLtd. (Goole, North Humberside, England).

Other are applicable to that this emulsifying agent is based on the fatty acid ester of anhydro sorbitol or sorbitol and the fatty acid ester blends of sucrose fatty acid ester, specifically are found in WO98/22085, in conjunction with in the present invention as a reference.

The hydrophilic surfactant that is applicable to this alternately or additionally comprises various any cationes known in the art, anion, amphion and amphoteric surfactant.For example referring to " detergent and emulsifying agent " the North America version (1986) of McCutcheon, Allured publishing company publishes; US-A-5011681 (people such as Ciotti, on April 30th, 1991 is open); US-A-4421769 (people such as Dixon, November 20 nineteen eighty-three is open); And US-A-3755560 (people such as Dickert, on August 28th, 1973 is open); These four pieces of documents are all in full in conjunction with in the present invention as a reference.

Various cationic surfactants are applicable to this.The cationic surfactant that is suitable for sees introduces this WO98/18444 for reference.

Various anion surfactants also are applicable to this.For example referring to US-A-3929678 (people such as Laughlin, December in 1975 30 days open), it is in full in conjunction with in the present invention as a reference.Typical anion surfactant comprises alkanoyl isethionic acid ester (C for example ₁₂-C ₃₀), alkyl and alkyl ether sulphate and salt thereof, alkyl and alkyl ether phosphate and salt thereof, alkyl methyl Calculus Bovis acid esters (C for example ₁₂-C ₃₀), and fatty acid soaps (for example alkali metal salt, for example sodium salt or potassium salt).

Both sexes and zwitterionic surfactant also are applicable to this.Be applicable to that the both sexes of the present composition and the example of zwitterionic surfactant are the compositions that extensively is described as aliphatic secondary amine and tertiary amines derived thing, aliphatic group wherein can be a straight or branched, and reducible 8-22 carbon atom (the preferred C that contains of one of aliphatic substituent group ₈-C ₁₈), and one comprises the anionic water-soluble group, for example carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.Imino-acetic acid Arrcostab and imino-diacetic alkanoic acid ester, and aminoalkyl esters, imidazoline and ammonium derivative.Other both sexes and zwitterionic surfactants that are suitable for can be selected from: betanin, sulfobetaines, hydroxyl sulfo betaine, alkyl sarcosine salt (for example, C ₁₂-C ₃₀), and the alkanoyl sarcosinate.

Preforming monolayer pellet part of the present invention can randomly contain the emulsifying agent or the surfactant of polysiloxanes.Various silicone emulsifiers are applicable to this.These silicone emulsifiers generally are through organically-modified organopolysiloxane, also are polysiloxane surfactant well known to those skilled in the art.The silicone emulsifiers that is suitable for comprises dimethicone copolyol.These materials be with polydimethylsiloxane--modified for containing polyether lateral chain, as polyoxyethylene chain, polyoxypropylene chains, their combination chain, and contain polyether chain derived from oxygen ethylene and oxypropylene.Other examples comprise alkyl-modified dimethicone copolyol,, contain C that is ₂-C ₃₀The chemical compound of side chain.Other dimethicone copolyols that are suitable for comprise the material that contains various cationes, anion, both sexes and amphion side chain.Other optional members

Other optional components that can comprise wide region in the device of the present invention.These annexing ingredients should be pharmaceutically useful." described various cosmetics and the medicinal ingredients that are usually used in the cosmetics industry that are applicable in the present composition in the CTFA cosmetic composition handbook (the 2nd edition, 1992), its full text combination in the present invention as a reference.The 537th page of limiting examples of having described the functional classification of composition in this handbook.The functional classification of these and other compositions comprises: abrasive material, absorbent, antibiotic, anticaking agent, dandruff removing agent, antiperspirant, antioxidant, bio-additive, bleach-activating, brightening agent, builder, buffer agent, chelating agen, chemical addition agent, coloring agent, enamel, cleaning agent, denaturant, the tooth nursing agent, deodorizer, decortication active component, depilatory, medicinal astringent, dyestuff, dye-transfer, enzyme, external-use analgesic, flavoring agent, film former, perfume composition, anthelmintic, antifungus agent, opacifier, oxidation dye, oxidant, insecticide, pH regulator agent, pH buffer agent, medicinal active ingredient, plasticizer, antiseptic, free radical scavenger, skin, hair or fingernail bleach, skin, hair or fingernail conditioner, skin, hair or fingernail permeation-promoter, stabilizing agent, surface amendment, Reducing agent, temperature inhibitor, and heating agent.

Beautify composition and also be applicable to this, as coloring agent, essential oil and skin, hair or fingernail consolidant.Other materials that are applicable to this comprise pigment.The pigment that is applicable to the present composition can be organic and/or inorganic constituents.Also comprise the material that belongs to the less colored or low gloss in the term pigment category,, and also comprise light scattering agent as the delustring finishing agent.The embodiment of the pigment that is suitable for has ferrum oxide, acyl glutamate ferrum oxide, titanium dioxide, ultramarine blue, D﹠amp; The C dyestuff, carmine, and their mixture.Can suitably use pigment composition according to the type of compositions.

The pH of the preformed monolayer pellet part of the present invention is preferably about 3 to about 9, and more preferably from about 4 to about 8.

Preformed monolayer pellet part of the present invention be have can with the paster or the facial film form of the size and dimension of institute site of administration outline good fit.Therefore, the long-pending size range of device surface of the present invention can be about 0.25cm ²To about 1000cm ²More preferably the yardstick on the yardstick of the one side at least of device, preferred two sides is greater than the thickness of device, and wherein the yardstick on preferred device surface is about 2: 1 to about 100: 1 with the ratio of thickness, is more preferably 5: 1 to about 50: 1.

Here the term of Cai Yonging " superficial dimension " is meant that along the yardstick of x-or y-axle, thickness is then measured along the z-axle.Its definite size and dimension will be decided according to purposes and product attribute.Preforming monolayer pellet part of the present invention is suitable for the part and is used for fingernail or epidermis, hair or scalp, human body face or its part, shank, hand, arm, foot, or trunk position.Device of the present invention for example can be square, circle, and rectangle, ellipse, or other shapes of forming by these shapes, as can be described as " semicircle ", " Donna cast ", or other shapes.Device can be made the shape that is suitable for facial application, surface area is about 0.25cm ²To about 500cm ², be preferably about 1cm ²To about 400cm ²The thickness of paster that third aspect present invention relates to or facial film device is extremely about 20mm of about 0.5mm, is preferably about 1mm to about 5mm.The thickness of paster that second aspect present invention relates to or facial film device is that about 0.5mm is to about 20mm, be preferably about 0.5mm to about 3mm, its thickness of thickening border region is extremely about 17.5mm of about 0.5mm, and thickness of its border region that approaches is extremely about 2.5mm of about 0.5mm.

Preforming monolayer pellet part of the present invention also can be made into or wear as hand, and foot is worn, or the body worn form.Hand is worn form and is generally comprised form of gloves or its part, and foot is worn form and generally comprised socks form or its part.Here the term of Cai Yonging " glove " comprises " mitten ".Preferred hand is worn form and is comprised glove body, and it comprises stage casing part, 1 to 4 finger-stall that links to each other with the stage casing, the thumbstall that links to each other with the stage casing, the palm of the hand one side and the back of the hand one side.Preferred foot is worn form and is comprised the socks body, its by an end seal, the sufficient shape tubular type of an end opening partly constitutes.Device of the present invention also can be made into or is used as the body worn form.Body worn is meant radially around being worn on the body part that has the longitudinal axis.Its end is connected with each other, and maybe can shorten its length, and it only partly is trapped among on the health.In any shape, the applying that adornment all can be fabulous with body part.These body parts generally comprise user's back, upper arm, forearm, thigh, shank, cervical region and trunk.

After device sticked, it can keep about 3 hours at application site, and preferred about 1 hour, more preferably less than 15 minutes.But preformed monolayer pellet part full wafer is removed.

According to the contained effective ingredient of preformed monolayer pellet part of the present invention, device of the present invention can have following purposes at least: the hydration of skin, hair or fingernail; Improve microgroove and wrinkle; The aesthetic nursing of acne; Skin compacts; Invigoration effect; Emollescence; Exfoliating Scrub; Improve and/or the homogenize colour of skin and/or skin texture; Skin, hair or the effect of fingernail light; Help the solarization effect; Reduce appearance of pores; Absorb or control secretions; The pain of prevention and/or alleviation skin, hair or fingernail, muscle; Reduce swelling, and/or black eye; Promote wound healing; Make skin, hair or fingernail gentleness, pure and fresh or nice and cool; Reduce inflammation; Make face brighten; Alleviate hyperemia; Alleviate expansion; The treatment dermatosis; Slow closing; Purification; Perfuming; Reduce antibacterial or growth of microorganism; The healing effect; Anthelmintic action; Remove disadvantageous hair, dirt or color make-up; Painted or the bleaching in position of this device is used in order.Preferred preformed sheet device of the present invention is used for the hydration of skin, hair or fingernail in the beauty treatment mode; Improve microgroove and wrinkle; Improve and/or the homogenize colour of skin and/or skin matter structure.Manufacture method

At least a effective ingredient and at least a gellable polymer gel form agent can be by the preforming monolayer pellet part of gelling step formation from support.The character of gelling step will be decided according to the characteristic of used polymer gel formation agent.For example, gelling step can comprise for cross-linked polymer solution adds metal ion, or comprise through ultraviolet radiation to form from the support gel.

In most cases, can finish gelling step by cooling.Comprising heating liquid, contained at least a effective ingredient is heated to first temperature with at least a gellable polymer gel formation agent and other optional members (or being referred to as into the glue mixture), this temperature is higher than into the gel point of glue mixture, is used to make this one-tenth glue mixture solubilising; Have in the mould of suitable shape becoming the glue mixture to add; Make this one-tenth glue mixture gelling under second temperature, this second temperature than first temperature low (being equal to or less than into the gel point of glue mixture) to form monolayer from the support device.In another embodiment, can heating when contained at least a effective ingredient and at least a gellable polymer gel being formed agent and optional components and place suitable mould.

Formation can add component when the support device jointly or successively in proper order.The addition sequence of component will be decided according to its character and characteristic.Preferred at least a effective ingredient and at least a gellable polymer gel form agent and can fully be dissolved in the liquid before other components add.It is basically or fully transparent that term " fully dissolving " is meant into the glue mixture.Should will become the temperature of glue mixture to remain on more than the gel point, finish until all components is added.In another embodiment, be suitable for before adding final component, just beginning to be lowered into the temperature of glue mixture.

At least a effective ingredient and at least a gellable polymer gel formation agent are remained valid the long time under the intensification condition." effectively " long time is to be enough to make at least a gellable polymer gel to form agent complete (or basically) be dissolved in the required enough time of liquid.

In preferred embodiments, adopt the injection moulding manufacturing to be somebody's turn to do from the support device.It is believed that the device surface of making thus processes more smoothly, so it is firmer, tear resistance is stronger.Adopt the injection moulding preparation when the support device,, wherein before implantation step, mixture is remained on first temperature that is higher than into glue mixture gel point comprising becoming the glue mixture to inject the mould of suitable shape; To become the glue mixture in the mould of suitable shape, to be cooled to second temperature that is lower than into glue mixture gel point, form monolayer from the support device.

In another kind of injection moulding, at least a effective ingredient and at least a gellable polymer gel can be formed agent and other optional components that may exist adds in proper order or adds simultaneously.When adopting injection moulding to be prepared, wherein at least a effective ingredient and at least a gellable polymer gel form agent should enough flowabilities, thereby also can easily supply with die head by any conventional method outside the injection moulding.Can add lubricant to help into of the perforate charging of glue mixture by extruder barrel.

Can adopt other various known technologies will become the glue mixture to supply with the model of suitable shape, these technology comprise: gravity filling system, and pneumatic or mechanical notes pressing system.Because the flowability and the low processing temperature of mixture, injection moulding is most preferred technology.Can adopt various moulding pressures.Moulding pressure generally is about 10 ⁵Pa (1 atmospheric pressure) is to about 5 * 10 ⁶Pa (50 atmospheric pressure), but the height of used pressure will be decided according to used molding technology.Advantage of the present invention is to adopt low pressure molding to go out the ability of device of the present invention.

When finishing gelling by cooling, molding temperature should be equal to or less than into the gel point of glue mixture certainly, to form from the support device.Can be before mixture be added mould, among or afterwards, reach suitable molding temperature.This device of molding also is cooled to temperature below the gel point, then with the device demoulding.Should need not special operational during in the demoulding from the support device.

In the device of first, second or fourth aspect of the present invention, device first surface and second surface at least the one side, preferably have nonplanar structure at second surface, wherein this nonplanar structure comprises at least two border region that do not have identical average thickness simultaneously, mould comprises at least one first die surface and second die surface, in first and second die surfaces at least the one side be in device first and second surfaces itself at least the one side negative-appearing image, and in first and second die surfaces at least the one side be the negative-appearing image of non-planar structure.Nonplanar structure is the shape of freely choosing, and comprises accompanying drawing 1-4,6-7, and the shape shown in 8-9 and the 10-12, but be not limited only to this.If have repetitions patterns on the nonplanar structure, then at least one mask has repetitions patterns in first and second die surfaces, and it has provided the negative-appearing image of the repetitions patterns that is at least simultaneously had in device first and second surfaces itself.

According to of the present invention first and the third aspect, have nonplanar structure on first and second surfaces of device, the preferred second surface, comprising patterned surface, it be the negative-appearing image of structuring action face, wherein structure employing Ra defines greater than 10 μ m.If nonplanar structure has repetitions patterns, then structuring action face has repetitions patterns, and it has provided the negative-appearing image of the repetitions patterns that is at least simultaneously had in device first and second surfaces itself.Its production method comprises and is prepared into the glue mixture, comprise at least a effective ingredient and at least a polymer gel in this mixture and form agent, and the optional member that may exist, and with described mixture heated to first temperature that is higher than the mixture gel point, be used to make into glue mixture solubilising; Mixture is placed the mould with suitable shape, in first and second surfaces of this mould at least the one side be in first surface of device own and the second surface at least the one side negative-appearing image; At least be preset with the structuring action face on the one side in first and second surfaces of mould, the structure of its negative-appearing image adopts Ra to define greater than 10 μ m; Make mixture be lower than second temperature of first temperature (being equal to or less than into the gel point of glue mixture) gelling; Removal structuring action face from the device.The removal step is carried out in gelling step carries out or afterwards.The structuring action face is selected from above-mentioned egative film, and condition is that the Ra of negative-appearing image of egative film outer surface is greater than 10 μ m.Shaping membrane is that preferred construction turns into the surface.

In another embodiment, when placing mould, heats in mixture.In another embodiment, the one side at least in mould first surface and the second surface is handled through structuring, can make the structuring action face by it by etching method or other methods known in the art.

When die surface or structuring action face have repetitions patterns when making the first surface of device and the nonplanar structure on the second surface have repetitions patterns, the pattern that repetitions patterns forms on the two sides can be linear array or alternative form.Preferred pattern is an alternative form.

Method of the present invention also comprise preparation the present invention first, second and the 3rd or the method for the preformed monolayer pellet part that relates to of fourth aspect, this method comprises and is prepared into the glue mixture, comprise at least a effective ingredient and at least a polymer gel in this mixture and form agent, and the optional member that may exist; And with described mixture heated to first temperature that is higher than the mixture gel point, be used to make into glue mixture solubilising; Mixture is placed mould with suitable shape, one side at least in first and second surfaces of this mould is the negative-appearing image of one side at least in first surface of device own and the second surface, in the first surface of device and the second surface at least the structure qualification on the one side at least two border region that do not have identical average thickness simultaneously; One side at least in first and second surfaces of mould is predetermined to be the structuring action face, and the structure that its negative-appearing image has adopts Ra to define greater than 10 μ m; Make mixture be lower than second temperature of first temperature (being equal to or less than into the gel point of glue mixture) gelling; Removal structuring action face from the device.

In another embodiment, when placing mould, heats in mixture.In another embodiment, the one side at least in mould first surface and the second surface is handled through structuring, can make the structuring action face by it by etching method or other methods known in the art.Appraisal procedure gel compression failure test

Mechanical performance by gel compression failure test determination preforming monolayer of the present invention pellet part.Relevant parameter is gel strength (by measuring the required compression stress of column type molding gel fracture), and the pliability of gel (by measuring the compression degree of gel at breakaway poing).Below test method is described in more detail.

(the compression failure test is carried out in Stable Micro Systems (SMS) structural analysis UK) only (TA) TA-XT2i type for Godalming, Surrey available from Stable Micro Systems Ltd in employing.System controls by SMS ' the s Texture ExpertExceed software (2.03 editions) that moves under Windows-98.Diameter is that the aluminum compressive plate (P-100 probe) of 100mm links to each other with the load unit of 50Kg.These are installed in the TA Probe Carrier, the machine control as calculated of its extending arm that vertically moves.

For the preparation sample, adopt following method to prepare gel preparation.In the mold of respective shapes, make (diameter 26mm * dark 12mm) accurate solid cylindrical gel film.Sealing contains the mold of sample to avoid evaporating during storage.At room temperature preserving gel film spends the night.Before test, just gel film is taken out the mold separately from it, estimate damaged situation.Abandon the gel film that has damaged (for example containing bubble), because the mechanical performance that these damaged meeting influences are measured.Then the N/D gel film is placed under the P100 compressive plate between two parties.

It is under power/compact model that Texture Expert Exceed software is installed.Compressive plate is preset in the 12.0mm elemental height.Fall off rate is set to 0.8mm/s, moves total distance and is set to 10.8mm (be gel film be compressed into 90% o'clock of its elemental height stop to measure).The position that power and compressive plate are collected automatically with the ratio of 200pps (point/second) by system.Software is preset as reaching maximum, force tense marker compressive plate position.Maximum, force is a fracture strength, i.e. the required power of gel film fracture.Compressive plate arrives the deformation range of the displacement sign gel of gel breakaway poing from its elemental height.Calculate the meansigma methods (generally carry out 5 time parallel assay) of sample, in newton in the maximum, force of breakaway poing.

Adopt the percent of the initial mold heights of gel to characterize the single shaft deformation (compression) of gel, that is: at breakaway poing

If gel does not rupture yet in 10.8mm stroke endpoint (i.e. 90% compression ratio), then gel is categorized as under this experimental condition ' not fracture '.Surface irregularity

(Medar USA) measures surface texture, and what it adopted is ripple interferometric analysis technology, has 30.7 μ m x-axle graphics resolutions, 35.8 μ my-axle graphics resolutions and 1.6 μ m z-axle graphics resolutions to adopt CADEYES surface analysis system.The representative of the patterned surface of the present invention first or the related device of the third aspect is by minus polysiloxanes casting product (the Silflo Silicone Impression Material of preparation structuring action face; FlexicoDevelopments UK) is prepared, and this structuring action face promptly is the action face that is used to prepare the preforming monolayer pellet part that the present invention first or the third aspect relate to.Adopt polysiloxanes casting product to replace actual preforming monolayer pellet part, this is because the optical characteristics of polysiloxanes cast-molding material more is applicable to the optical surface analysis.

Adopt following method to prepare polysiloxanes casting product:

1. the polysiloxanes paste that with circle diameter is 2.54cm (1 inch) fully mixes about 1 minute with 1 catalyst.

2. adopt spatula that polysiloxane mixture is coated on the structuring action face, under room temperature/ambient temperature, solidified about 7 minutes.

3. after solidifying, polysiloxanes casting product are removed and analyze from the structuring action face.

The data of surface irregularity that are used to describe the polysiloxanes casting product of the patterned surface that characterizes the present invention first or the related device of the third aspect comprise Ra, and it is with respect to the suitableeest plane, based on the average deviation on surface, wherein

Ra = 1 / n Σ_{i = 1}^{n} z_{i}

Wherein z be certain a bit on the value of calculation of the suitableeest absolute altitude (elevation) deduct the absolute value of this absolute altitude measured value; This point the value of calculation of suitable absolute altitude be absolute altitude between the suitableeest plane and actual measurement surface at this point.The record data that are used to characterize surface irregularity also comprise Rq, and it is with respect to the suitableeest surface, based on the root-mean-square-deviation on surface, and Rz, 10-point unevenness.

Rq is with respect to the suitableeest surface, based on the root-mean-square-deviation of bottom, surface

Rq = \sqrt{1 / n Σ_{i = 1}^{n} {z_{i}}^{2}}

Rz is 10 average unevenness along all scanning lines of x direction,

Rz＝((S ₁+S ₃+S ₅+S ₇+S ₉)-(S ₂+S ₄+S ₆+S ₈+S ₁₀))/5

S wherein ₁, S ₃, S ₅, S ₇, S ₉Be along scanning line apart from the suitableeest planar 5 salient point end values the highest, and S ₂, S ₄, S ₆, S ₈, S ₁₀Be along scanning line apart from the suitableeest planar 5 groove minimums.The suitableeest plane described here calculates automatically through CADEYES surface analysis system, and i is the subscript of expression particular analysis point, and n is the sum of analysis site, for example for 1cm ²Area, n is 90,987.

Although adopt ripple interferometric analysis technology can measure the surface texture of these samples, (x and y axle graphics resolution are lower than 40 μ m also can to adopt various suitable configurations; Z axle graphics resolution is lower than 2 μ m), surface scan technology (for example, needle point face shape algoscopy, lasing area shape algoscopy, or edge projection method (fringe projection)) measures surface texture to obtain these data.Another method of measuring Ra and Rq is that wherein Ra is defined as the arithmetic average deviation of tested profile, and Rq is defined as the root-mean-square-deviation of tested profile by the base-line method (linebased method) described in the ISO4287 (1997).Surface brightness

The structuring action face is placed on the glue mixture, contain 0.83% agarose in this mixture, 0.3%Kelgum  (1: 1 mixture of xanthan gum and tracasol, available from Kelco, San Diego, CA, USA), 20% glycerol, 10% nicotiamide, 1% pantothenylol, 5% butanediol, 0.15%NipaginA (ethylparaben, available from Nipa Laboratories, Inc., Wilmington, DE, USA), 0.1%Hampene Na ²(the EDTA disodium, available from Hampshire Chemical, Lexington, MA, USA), 62.62% deionized water.After gel structure is fixing, remove the structuring action face.Opaque (black) that adopts Leneta Card then partly this patterned surface of (available from Leneta company) preformed monolayer pellet part that the present invention first or the third aspect are related to carries out brightness and measures (promptly measuring the surface reflectance degree).(BYK Gardner, Sliver Spring MD) measure surface reflectance degree percent, wherein reading are set in 20 degree (20 °), 60 degree (60 °) and 85 degree (85 °) to adopt BYK-Gardner MicroTri-Gloss instrument.The gel transparency

The assessment of printed text visibility is measured the transparency of gel by seeing through device of the present invention.Employing Microsoft Word Arial font also goes up printing English letter (capitalization) through LaserJet 4 Plus printers (Hewlett Packard) (being equipped with the black print cartridge) at transparent membrane (Universal OfficeSupplies) and makes this printed text.Making font size is the transparent membrane that produces of 4-8 pound.The transparent membrane that produces is placed on the blank sheet of paper guaranteeing that background is even, and all samples are all assessed under conventional indoor light condition.

It is the gel film of 7mm that tested gel sample forms thickness through mold pressing.Before this gel film placed the transparent membrane that is printed on 4 pounds of font sizes, see through the gel film assessment to the letter punch visibility.If it is invisible to see through gel film this document, then gel film is placed assessment once more before the letter of next maximum point size.Repeat this method and see that until seeing through gel alphabetical point size reaches visible level.See through " transparency threshold value " that the visible minimum point size of gel sample promptly is considered to gel.Preferred " the transparency threshold value " that be used to prepare the gel of device of the present invention is 10 pounds of font sizes (font size), is more preferably 7 pounds of font sizes, especially preferably 4 pounds of font sizes.Embodiment

The present invention will be described to adopt following examples.

Embodiment 1-3

123 composition % (weight) % (weight) % (weight) agarose-0.4 0.8 tracasol-0.27-Rheolex RX-Ls 0.3--xanthan gum 0.1 0.13-

--0.3 gum gellan, 1.0 0.4-glycerine, 20.0 20.0 15.0 butanediol 5.0-8.0 panthenols, 1.0 2.0 2.0 niacinamide-many oleic acids of 5.0-sucrose ester--0.5 polysorbate60--0.2 dimethicone copolyol 0.02 0.02-benzylalcohol-0.3 0.2 ethyl-para-hydroxybenzoate 0.2 0.1-propylparaben-0.05-EDTA disodium-0.1-calcium chloride 0.1 0.08-water adds to 100 and adds to 100 and add to 100 disruptive forces (newton), 82 73 102 compression ratios, 26 44 58 negative papers²--

¹Kelgum ^TMBe 1: 1 mixture of xanthan gum and tracasol, available from Kelco, San Diego, CA, USA.

²Paper is " Kimwipes EX-L ", available from Kimberley-Clark Corp., Roswell, GA, USA.

With polysaccharide glue mix with water form the homogenizing dispersion (this step can by with polysaccharide pre-dispersed in non-solvent for example in the polyhydric alcohol and easily reach), add other annexing ingredients.Mixture is heated with stirring to first temperature (about 90 ℃) that is higher than the mixture gel point, makes the abundant hydration of polysaccharide glue.Then liquid gel is distributed in the mould of suitable shape (embodiment 3).Embodiment 1 and 2 device are injection molding in the mould of suitable shape.The molding of preferred employing injection moulding.Can eliminate like this may by the cutting gel cause damaged, and can improve the robustness of device.Injection moulding also can make device be easy to form three dimensional structure.Then liquid gel is cooled to second temperature (for example room temperature) that is lower than first temperature, is equal to or less than the mixture gel point so that gel structure condenses.Then can be with this device demoulding.The described device of embodiment 1-3 is respectively shown in accompanying drawing 1-3.Described device can be packed to reduce the mummification of device in storage with low water vapor permeation material then.The packing that is applicable to this device comprises pouch or sealing ware.If device is packaged into pouch, then preferably sealing before use.Can provide protection by egative film or peelable lining such as plastic foil, it is easy to peel off down from device.

If adopt egative film (embodiment 1), can before gel distributes, egative film be placed the mould of suitable shape, or in the liquid gel cooling step, egative film be placed on the gel surface.

In some compositions, can in prescription, add metal ion (Ca for example ²⁺, K ⁺) (embodiment 1 and 2) to promote the gel strength of device.In this case, before allocation step is implemented, metal ion is added with the aqueous solution form at once, and stir in the adding liquid gel.

Can improve said method according to need according to the characteristic of any annexing ingredient.For example, if there is nonaqueous component, will molding or casting before homogenize this liquid gel to guarantee the dispersion of nonaqueous component.Similarly, if added the thermal sensitivity composition, then should be after glue closes step preparation be cooled to preference temperature (deciding), and in this step, adds the thermal sensitivity composition according to composition.

Can for example make the liquid gel degassing, to remove dispersive bubble in the liquid through evacuation.If there is this degassing subsequent step, then should be the final step before liquid gel distributes.

As implied above, preformed pellet part has fabulous intensity and pliability.

Embodiment 4

The prescription that adopts 50/50 (w/w) organopolysiloxane gel to form agent and be used to prepare preformed pellet part as the ascorbic acid and the derivant thereof of effective ingredient.When preparing this prescription, under 115-120 ℃, 0.025 part anhydrous ammonia existence condition, made by following composition condensation: the xylene solution of the polyorganosiloxane resin copolymer of 67 part 70% (weight), it mainly is about 0.75: 1 (CH by mol ratio ₃) ₃SiO _1/2Unit and SiO _4/2The unit constitutes, and contains the hydroxyl of 2.7% (weight) of amount of solid approximately, can measure by FTIR (ASTM E-168), and 31 parts through hydroxy-end capped polydimethylsiloxane, and its viscosity under 25 ℃ is about 13,500cP (mP.s), and 2 parts of dimethylbenzene.Behind the condensation reaction, this mixture was heated to 140 ℃ to remove excess of ammonia through 1 hour.

(superfines Hoffman-LaRoche) mixed mutually with the ascorbic acid of polysiloxanes material and identical weight and derivant thereof through 17 minutes to adopt the Lee tilting rustless steel still add built-in Eppinbach high-shear mixer then.

Polysiloxane solution is transferred in the mould with suitable shape, and air dried overnight makes solvent evaporation.The device demoulding and packing with gained.Find that this preforming pellet part that contains polysiloxanes is suitable for carrying ascorbic acid and the derivant thereof as active component on skin, hair or fingernail.

Embodiment 5

The acrylic compounds pressure-sensitive adhesive (Draize grade 0-1) that 50 parts (dry weights) are dissolved in the medical grade of ethyl acetate and toluene and 50 parts of ascorbic acid and derivant thereof and sodium ascorbate (be dry powder, weight ratio is 1: 22 (w/w)) are mixed to form the effective adhesive matrix of beauty treatment.It is changed in the mould with suitable shape, solidify down at 121.2 ℃.Find that this preformed pellet part is applicable to skin, hair or fingernail and carry at least a effective ingredient.

Embodiment 6 composition % (weight) agar 0.6 agarose 0.3 tracasol 0.1 Rheolex RX-L 0.2 xanthans 0.1 glycerine 15.0 panthenols 3.0 polysorbate60s 0.08 benzylalcohol 0.3 ethyl-para-hydroxybenzoate 0.1 propylparaben 0.05 water adds to 100 disruptive forces, 78 compression percentages 58

With polysaccharide glue and the mixed homogeneous dispersion that forms of water, add supplementary element.Can be by polysaccharide is pre-dispersed in non-solvent (for example polyhydric alcohol) and easily make homogeneous dispersion.This mixture is heated with stirring to about 90 ℃, so that the abundant hydration of polysaccharide glue.Can for example make the liquid gel degassing, to remove dispersive bubble in the liquid through evacuation.Liquid gel is allocated in the mould with suitable shape then, is cooled to room temperature then, the immobilized gel structure.Then with the device demoulding.In addition, but the liquid gel casting forms sheet material, can be from the device of this gel sheet cutting suitable shape.The device of embodiment 6 as shown in Figure 4.Described device can be packed to reduce the mummification of device in storage with low water vapor permeation material then.

Adopt various structuring action face that the surface irregularity (table 1) and the surface reflectance degree (table 2) of device parallel sample are assessed.Before the liquid gel gelatinization or among the structuring action face is contacted with device.The unevenness structuring action face Ra Rq Rz of table 1-polysiloxanes casting product surface does not have 4.85 6.32 14.1360 orders, X-7189 ²21.10 34.37 93.9340hex, X-2S137 ²92.27 133.51 353.78VFE, 3.4mil, X-15928 ²160.22 189.26 441.45DRI-WEAVE have pattern #35/7 171.18 206.07 527.44 shaped by fluid pressure film ¹315.26 360.85 786.01

¹US-A4, the shaped by fluid pressure film of describing among 609,518 (people such as Curro, JIUYUE was authorized on the 2nd in 1986) with micropore and macropore.Preferred macropore has the teardrop shape pattern, and wherein 12% open area comprises 24 macropores for every square centimeter on pattern, and wherein macropore is 1.54mm along the bottom of diameter ², the end is 0.3mm ², aperture forms on the screen cloth of 100 order patterns.

²Available from Tredegar Film Products, 1100 Boulders Parkway, Richmond, VA, USA 23225.

All patterned surfaces relevant with above-mentioned egative film preferably are shaping membrane.

Here the Ra that all has greater than 10 μ m of the negative-appearing image of the suitable structuring action face of Ding Yi all is preferably greater than 20 μ m, measures as mentioned above.

The preferable range of negative-appearing image that is used for the structuring action face of device of the present invention be Ra greater than 10 μ m, and be lower than 316 μ m, measure as mentioned above.The Rq of the negative-appearing image of the structuring action face that is suitable for of the present invention's definition is preferably greater than 30 μ m and/or most preferably is lower than 375 μ m greater than 7 μ m.The Rz of the negative-appearing image of the structuring action face that is suitable for is preferably greater than 75 μ m greater than 15 μ m, more preferably greater than 90 μ m, and/or most preferably less than 800 μ m.The surface reflectance degree % structuring action face of table 2-patterned surface does not have 48 64.8 72.860 orders, X-7189 for 20 ° 60 ° 85 ° ²0.9 4.0 4.340hex, X-2S137 ²1.8 7.2 4.3DRI-WEAVE have pattern #35/7 2.5 14.3 17.2 shaped by fluid pressure film ¹0.3 0.8 0.35VFE, 3.4mil, X-15928 ²2.7 23.6 19.2

¹US-A4, the shaped by fluid pressure film of describing among 609,518 (people such as Curro, JIUYUE was authorized on the 2nd in 1986) with micropore and macropore.Preferred macropore has the teardrop shape pattern, and wherein 12% open area comprises 24 macropores for every square centimeter on pattern, and wherein macropore is 1.54mm along the bottom of diameter ², the end is 0.3mm ², aperture forms on the screen cloth of 100 order patterns. ²Available from Tredegar Film Products, 1100 Boulders Parkway, Richmond, VA, USA 23225.

All patterned surfaces of the present invention definition for the preferred light brightness range of 20 °, 60 ° and 85 ° situations respectively＜40,＜58 and＜65.The preferable range of device brightness of the present invention is to be respectively 0-10,0-30 and 0-25 for 20 °, 60 ° and 85 ° of situations.Most preferred brightness scope is to be respectively 0-5,0-25 and 0-20 for 20 °, 60 ° and 85 ° of situations.

Embodiment 7

% (weight) agarose 0.9 glycerol 20.0 butanediols 5.0 ethylparaben 0.15EDTA disodiums 0.1 water adds to 100

With polysaccharide glue and the mixed homogeneous dispersion that forms of water, add supplementary element.Can be by polysaccharide is pre-dispersed in non-solvent (for example polyhydric alcohol) and easily make homogeneous dispersion.Become the glue mixture to be heated with stirring to about 90 ℃ this, so that the abundant hydration of polysaccharide glue.After with the liquid gel degassing (as through evacuation), become the glue mixture to be transferred to (for example mould is for making the shape of the paster device shown in accompanying drawing 6 and 7) in the mould with suitable shape liquid.

Adopt preceding method to assess the gel transparency of this device, its transparency threshold value is 4 pounds of font sizes.

Claims

1. preformed monolayer pellet part (10,110,210,310 that is used for carrying effective ingredient to skin, hair or fingernail, 410,510,610,710,810), this device has by periphery (12,112,212,512,612,712,812) first and second surfaces (14 of the separation of Xian Dinging, 114,214,314,414,514,614,714,814; 16,116,216,316,416,516,616,716,816); This device comprises at least a effective ingredient and at least a polymer gel forms agent; And this device has nonplanar structure on the one side at least in first and second surfaces.

2. preformed monolayer pellet part (10,110,210,310 that is used for carrying effective ingredient to skin, hair or fingernail, 510,610,710,810), this device has by periphery (12,112,212,512,612,712,812) first and second surfaces (14,114 of the separation of Xian Dinging, 214,314,514,614,714,814; 16,116,216,316,516,616,716,816); This device comprises at least a effective ingredient and at least a polymer gel forms agent; And this device has nonplanar structure on the one side at least in first and second surfaces, and this planar structure comprises at least two border region (22,122,222,322,522,622,722,822 that link to each other that do not have identical average thickness simultaneously; 18,118,818; 20,220,320; 524,624,724).

3. the device of claim 2, wherein one of at least two border region comprise the flange (18,118,818) that links to each other with periphery (12,112,822).

4. claim 2 or 3 device, wherein one of at least two border region comprise the convex ridge (20,220,320) that at least one is positioned at periphery (12,212) central authorities.

5. the described device of arbitrary claim among the claim 2-4, wherein one of at least two border region comprise embossed marks.

6. the described device of arbitrary claim among the claim 2-5, wherein second surface is away from skin, hair or fingernail, this second surface (16,116,216,316,516,616,716,816) have nonplanar structure, and comprise patterned surface, it is the negative-appearing image of structuring action face, and the structure of the negative-appearing image of this structuring action face adopts Ra to be defined greater than 10 μ m.

7. the device of claim 6, wherein first surface links to each other with skin, hair or fingernail, this first surface (14,114,214,314,514,614,714,814) have nonplanar structure, wherein comprise patterned surface, it is the negative-appearing image of structuring action face, and the structure of the negative-appearing image of this structuring action face adopts Ra to be defined greater than 10 μ m.

8. method for preparing the described preformed monolayer pellet part of arbitrary claim in the aforesaid right requirement, this method may further comprise the steps: be provided as the glue mixture in mould, wherein contain at least a effective ingredient and at least a gellable polymer gel formation agent, at least one surface of this mould is the negative-appearing image of nonplanar structure or each nonplanar structure, this nonplanar structure comprises at least two border region that do not have identical average thickness simultaneously, or comprise patterned surface, this patterned surface is the negative-appearing image of structuring action face, and the structure of the negative-appearing image of this structuring action face adopts Ra to be defined greater than 10 μ m; Or comprise above two kinds of situations; Make this one-tenth glue mixture gelling then.

9. the method for claim 12, the wherein said step that provides is an injection moulding process.

10. claim 12 or 13 method, wherein nonplanar structure is positioned at second surface (16,116,216,316,516,616,716,816), and comprise at least two border region (22,122,222 that do not have identical average thickness simultaneously, 322,522,622,722,822; 18,118,818; 20,220,320; 524,624,724,824), and at least one of described at least two border region has patterned surface.

11. the described method of arbitrary claim among the claim 12-14, wherein this device is at first surface (14,114,214,314,514,614,714,814) also comprise nonplanar structure on, this nonplanar structure comprises patterned surface, and it is the negative-appearing image of structuring action face, and the structure of the negative-appearing image of this structuring action face adopts Ra to be defined greater than 10 μ m.

12. preformed monolayer pellet part (410 that is used for carrying effective ingredient to skin, hair or fingernail, 810), this device comprises at least a effective ingredient and at least a polymer gel forms agent, and this device has first and second surfaces (414,814 at the interval that is limited by periphery; 414,816), first surface (414 when using, 814) link to each other with skin, hair or fingernail, second surface (416,816) has nonplanar structure, and this nonplanar structure comprises patterned surface, it is the negative-appearing image of structuring action face, and the structure of the negative-appearing image of this structuring action face adopts Ra to be defined greater than 10 μ m.

13. the device described in arbitrary claim in claim 1-7 or 12, wherein this device combines with egative film.

14. the device described in arbitrary claim among the claim 1-7,12 or 13, it is the water-soluble polymer gel former that wherein at least a polymer gel forms agent.

15. the device described in arbitrary claim among claim 1-7 or the 12-14, wherein second surface (316,416,816) 20 ° brightness values less than 40, preferably less than 10, most preferably less than 5.

16. the device of claim 15, wherein the brightness values of 60 ° of second surfaces is less than 58, preferably less than 30, most preferably less than 25.

17. the device of claim 15 or 16, wherein the brightness values of 85 ° of second surfaces is less than 65, preferably less than 25, most preferably less than 20.

18. the described device of arbitrary claim among the claim 12-17, wherein at least one bread contains two continuous border region that do not have identical average thickness simultaneously in first and second surfaces.

19. the described device of arbitrary claim among claim 1-7 or the 12-18, wherein the transparency threshold value of this device is not more than 10 pounds of font sizes, preferably is not more than 7 pounds of font sizes, most preferably is not more than 4 pounds of font sizes.

20. the described device of arbitrary claim among claim 1-7 or the 12-18, it is a patch form.

21. the described device of arbitrary claim among claim 1-7 or the 12-20, it is packaged in the protective package thing of sealing.

22. method for preparing the described preformed monolayer pellet part of arbitrary claim among claim 1 and the 12-21, this method may further comprise the steps: be provided as the glue mixture in mould, wherein comprise at least a effective ingredient and at least a gellable polymer gel formation agent, wherein the first surface of this mould has a structure, and it is the negative-appearing image of described first surface (814); The structuring action face is contacted with the second surface (816) that becomes the glue mixture; The described one-tenth glue of gelling mixture; Remove this structuring action face down from device then.

23. the method for claim 22, wherein the described structure of mould first surface is to limit at least two border region (822 that do not have identical average thickness simultaneously; The negative-appearing image of device first surface 824), and/or the negative-appearing image of patterned surface, this patterned surface are the negative-appearing images of structuring action face, and its structure adopts Ra to be defined greater than 10 μ m.

24. the described method of arbitrary claim among claim 8-11 or the 22-23 wherein also comprises the step of device sealing in the protective package thing.

25. method of carrying at least a beauty treatment effective ingredient to skin, hair or fingernail, comprising the described device of arbitrary claim among claim 1-7 and the 12-21 is contacted with skin, hair or fingernail, this device comprises at least a beauty treatment effective ingredient and at least a polymer gel forms agent.

26. the preformed monolayer pellet part among claim 1-7 or the 12-21 described in arbitrary claim, it is facial film or patch form, its have can with the size and dimension of fingernail or epidermis, hair or scalp, human body face or other positions, shank, arm, hand, foot or trunk good fit.

27. the preformed monolayer pellet part among claim 1-7 or the 12-21 described in arbitrary claim, its form is selected from hand and wears, and foot is worn, or the body worn form.