CN1372942A - Composition for losing weight of mammal - Google Patents
Composition for losing weight of mammal Download PDFInfo
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- CN1372942A CN1372942A CN 01104891 CN01104891A CN1372942A CN 1372942 A CN1372942 A CN 1372942A CN 01104891 CN01104891 CN 01104891 CN 01104891 A CN01104891 A CN 01104891A CN 1372942 A CN1372942 A CN 1372942A
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- semen cassiae
- folium ilicis
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Abstract
A composition for losing weight of mammal, especially the people, is characterized by that its active components are lectuce tea and cassia seed.
Description
The present invention relates to be used to make the compositions of weight of mammal loss of weight, it comprises as the Folium Ilicis of active component and Semen Cassiae.More specifically say, the present invention relates to be used for the compositions of human body weight loss of weight, it is characterized in that: with Folium Ilicis and Semen Cassiae coupling.
Folium Ilicis (Ilex Kudingcha.C.J.Tseng) is a conventional Chinese medicine, and many tender leaf or leaves with plant are used as medicine, and have the effect of clearing away heat and cooling blood, the liver and kidney nourishing; The diffusing wind of energy, refresh oneself, relieving thirst and restlessness are used for the treatment of diseases such as headache, toothache, conjunctival congestion, calentura excessive thirst and dysentery more.Claim Folium Ilicis " to separate greasy sheep cattle poison ... by the expectorant therapeutic method to keep the adverse QI flowing downwards, postcibal diarrhea " according to " detailed outline is picked up any lost article from the road ".Folium Ilicis in Guangdong use among the people with a long history, have clearing away liver-fire, a wind heat of loosing, the effect of removing people's fat.Semen Cassiae is the dry mature seed of leguminous plant Semen Cassiae (Cassia otusifolis) or little Semen Cassiae (Cassia tora), and its function is loosening bowel to relieve constipation, wind and heat eliminating, liver heat removing and eyesight improving.The clinical diseases such as hyperlipemia, vascular hypertension, constipation, conjunctival congestion and swelling pain, blue or green order, nyctalopia that are used for.Modern study shows that these two kinds of Chinese medicines can both reduce the content of plasma cholesterol and triglyceride, have effects such as blood fat reducing, fat-reducing, loosening bowel to relieve constipation.
Obesity is to threaten a big reason of human health now and become the Social disease that the public worries very much day by day.Obesity can cause human a series of disease usually, as cardiovascular and cerebrovascular disease.Therefore, the product of the new overweight body weight of reduction mammal of exploitation (also claiming fat) is needs very.
The objective of the invention is to develop the product of the new overweight body weight of reduction mammal.
The inventor has now found that after deliberation plant Folium Ilicis and Semen Cassiae coupling can significantly be eliminated and crosses fattiness in the mammalian body and reduce overweight body weight of mammal or obesity.And Folium Ilicis and Semen Cassiae coupling and Folium Ilicis or Semen Cassiae list be with comparing, in eliminating mammalian body, cross fattiness and reduce the overweight body weight of mammal or fat aspect show synergism.The present invention is based on above-mentioned discovery is accomplished.
Therefore first aspect present invention relates to and is used to reduce the overweight or fat compositions of weight of mammal, and it comprises the plant Semen Cassiae, plant Folium Ilicis and usual excipients or carrier.
Further aspect of the present invention relates to plant Semen Cassiae and plant Folium Ilicis and unites to be used to prepare and be used to reduce the overweight or fat compositions of weight of mammal.
Further aspect of the present invention relates to and is used to reduce the overweight or fat preparation of compositions method of weight of mammal, and it comprises the plant Semen Cassiae, and the plant Folium Ilicis is with common carrier or mixed with excipients.
Term among the present invention " mammal " is meant and comprises human mammal.
Say that more specifically the present invention relates to be used to reduce the overweight or fat compositions of weight of mammal, it comprises the plant Semen Cassiae, plant Folium Ilicis and usual excipients or carrier.
According to the present invention, the present invention is used to reduce the overweight or fat compositions of weight of mammal and is characterised in that: contain plant Semen Cassiae and plant Folium Ilicis simultaneously.
According to the present invention, the present invention is used to reduce the overweight or fat compositions of weight of mammal also can contain other adding ingredients such as Radix Angelicae Sinensis, Aloe and Margarita powder.
According to the present invention, the ratio of Semen Cassiae and Folium Ilicis is 9 by weight in the present composition: 1-1: 9, preferred 5: 1-1: 5, and more preferably 2: 1.
According to the present invention, the Semen Cassiae that uses among the present invention is the mature seed of Semen Cassiae.The Folium Ilicis that uses among the present invention is the leaf of Folium Ilicis.
According to the present invention, the Semen Cassiae mature seed that uses among the present invention is to use as the ethanol extraction form with the water extract of Semen Cassiae mature seed or with the miscible extractive with organic solvent of water.The Folium Ilicis that uses among the present invention is to use as the ethanol extraction form with the water extract of Ilex latifolia tea-leaf or with the miscible extractive with organic solvent of water.
Say that more specifically the Semen Cassiae mature seed among the present invention or the water extract of Ilex latifolia tea-leaf are to obtain at 50 ℃-100 ℃ Semen Cassiae mature seed or the pulverizing Ilex latifolia tea-leafs of pulverizing with water extraction.Semen Cassiae mature seed among the present invention or Folium Ilicis be to use directly to extract the Semen Cassiae mature seed of pulverizing with water miscibles organic solvent such as ethanol or the Folium Ilicis of pulverizing obtains with the water miscibles organic solvent extract, or use with water miscibles organic solvent and obtain as Ethanol Treatment Semen Cassiae mature seed or Folium Ilicis water extract.Further say, coupling at Semen Cassiae of the present invention and Folium Ilicis, also can adopt Semen Cassiae and Folium Ilicis water extract or with the water miscibles organic solvent extract, promptly at first the Semen Cassiae mature seed of pulverizing and the Ilex latifolia tea-leaf of pulverizing are mixed by a certain percentage, then 50 ℃ of-100 ℃ of waters or with water miscibles organic solvent such as ethanol extraction, or use water extract with water miscibles organic solvent such as Ethanol Treatment Semen Cassiae and Folium Ilicis mixture.
Therefore Semen Cassiae of the present invention and Folium Ilicis coupling can be following forms: i) coupling of the water extract of Semen Cassiae mature seed and Ilex latifolia tea-leaf water extract or above-mentioned Semen Cassiae and Folium Ilicis water extract are further used the coupling with the extract of water miscibles organic solvent such as Ethanol Treatment; Ii) the Semen Cassiae mature seed and coupling water miscibles organic solvent extract and Ilex latifolia tea-leaf and water miscibles organic solvent extract; Iii) the water extract of the blended by a certain percentage water extract of Semen Cassiae mature seed and Ilex latifolia tea-leaf or above-mentioned Semen Cassiae and Folium Ilicis mixture is further used the extract with water miscibles organic solvent such as Ethanol Treatment; Iv) Semen Cassiae mature seed and Ilex latifolia tea-leaf blended by a certain percentage with the water miscibles organic solvent extract.
According to the present invention, the present invention is used to reduce the overweight body weight of mammal or fat compositions can be used separately or use with the suitable dosage forms form, as oral liquid, and tablet, soft capsule, hard capsule etc.
The following examples are used to further specify the present invention, but do not mean that any limitation of the invention.
Embodiment 1
The preparation of Semen Cassiae and Folium Ilicis water extract or ethanol extraction
With Semen Cassiae 10Kg, Folium Ilicis leaf 5Kg, wherein Semen Cassiae is broken shell into pieces, drops in the multi-function extractor, adds the water of 10 times of amounts, decocts secondary, each 1 hour in 100 ℃ of heating.Filter the back merging filtrate, get the water extract of Semen Cassiae and Folium Ilicis.The gained water extract can further join in the concentration tank reduce pressure (0.08Pa), and to be concentrated into proportion be 1.06 (50 ℃), put to room temperature, the concentrated water extract of Semen Cassiae and Folium Ilicis.As needs, concentrate toward gained and to add 95% ethanol in the water extract and make it to become 65% alcoholic solution, left standstill 24 hours, get supernatant, reclaim ethanol, being evaporated to proportion is 1.10.Concentrated solution is put into vacuum drying oven, and vacuum is 0.08Kpa, and the control temperature is below 80 ℃, and dry 24 hours, 1.80Kg got dry extract.
Embodiment 2
Contain the capsule preparation of Semen Cassiae and Folium Ilicis
Get by the dried cream 2kg that executes the preparation of example 1 method, pulverize, cross 60 mesh sieves, add eumenol powder 0.20Kg, Aloe juice xeraphium 0.77Kg, Margarita powder 0.13Kg, mix homogeneously carries out microwave sterilizating and handles.Powder after the sterilization is carried out hygiology heavy metal, functional component Determination on content, be filled into 0 after meeting
*In the capsule, the control loading amount is bottled 60 every bottle at the 0.470-0.530g/ grain.
Embodiment 3
Contain the oral liquid preparation of Semen Cassiae and Folium Ilicis
To be adjusted to certain density with the water extract or the ethanol extraction of Folium Ilicis by the Semen Cassiae of embodiment 1 preparation, water extract in this way, this density is 1.06, ethanol extraction in this way, alcohol is not distinguished the flavor of and density is 1.10 to having then need to reclaim ethanol; Add correctives and other adjuvant then, sterilization, fill.
Embodiment 4
Contain the granule preparation of Semen Cassiae and Folium Ilicis
Will be by the Semen Cassiae of embodiment 1 described preparation, the dry powder of Folum Ilicis extract and Aloe powder, Margarita powder etc. and adjuvant mix homogeneously are granulated, sterilization, last packing.
Embodiment 5
The Semen Cassiae of different proportion and Folium Ilicis mixture are to β-hydroxyl-β-first glutaryl CoA-reductase (HMG-CoA reductase, influence EC1.1.1.34)
Sample: by the extraction extract powder of the Semen Cassiae of embodiment 1 method preparation and Folium Ilicis mixture by Semen Cassiae: 1: 9,2: 8,3: 7,4: 6,5: 6,6: 4,7: 3,8: 2,9: 1 part by weight of Folium Ilicis are mixed with, take by weighing Semen Cassiae and Folium Ilicis different proportion but same weight mixture with a certain amount of dissolved in distilled water, standby.
Method and result treatment: the HMG-CoA reductase is configured to certain density enzyme reaction solution, in the reactant liquor of same amount, adds different proportion Semen Cassiae and the Folium Ilicis mixture liquid and the distilled water (blank) of equal volume, and measure the activity of enzyme.Determination of activity is carried out according to the Joachim method.Blank group activity is made as 100%, each organize enzymatic activity compare with the blank group final result.If it is as shown in table 1.
Table 1: the mixed liquor of different proportion Semen Cassiae and Folium Ilicis is to the influence of HMG-CoA reductase activity
| Semen Cassiae: Folium Ilicis ratio | Distilled water | ?1∶9 | ?2∶8 | ?3∶7 | ?4∶6 |
| Relative activity (%) | 100 | ?89 | ?80 | ?72 | ?66 |
| Semen Cassiae: Folium Ilicis ratio | 5∶5 | ?6∶4 | ?7∶3 | ?8∶2 | ?9∶1 |
| Relative activity (%) | 61 | ?57 | ?58 | ?63 | ?65 |
Discuss: β-hydroxyl-β-first glutaryl CoA-reductase (, EC1.1.1.34) being is coenzyme with NADPH, catalysis HMG-CoA is reduced to the enzyme of mevalonic acid (MVA), is the rate-limiting enzyme of synthetic cholesterol, and is significant to the biosynthesis of control cholesterol.This experiment by different proportion Semen Cassiae and the coupling of Folium Ilicis to the influence of this enzymatic activity, show that both ratios all had lipid-lowering effect preferably between 1: 9 to 9: 1.
Embodiment 6
Semen Cassiae and Folium Ilicis coupling on the fat model of mice blood fat reducing and the body weight effect is fallen.
Sample: Semen Cassiae and Folium Ilicis coupling and weight ratio are that 2: 1 water extract makes (being called for short the connection combination group from now on) by the described method of embodiment, and this connection combination group distilled water is the solvent preparation, irritates stomach and gives, and dosage is the 0.67g/kg body weight; Independent Folium Ilicis water extract group (being called for short the Folium Ilicis group from now on), dosage is the 1.34g/kg body weight; Independent Semen Cassiae water extract group (being called for short the Semen Cassiae group from now on), dosage is the 1.34g/kg body weight, matched group gives a certain amount of distilled water.
Laboratory animal: the Zhejiang Academy of Medical Sciences Experimental Animal Center provides male SD rat, body weight 60-90 gram.
High lipid food: 80% normal feedstuff, 10% Adeps Sus domestica, 10% yolk powder are mixed and made into.
Experimental technique: get 60 of male SD rats, high lipid food group (50) and normal diet group (10), 2/cage, ad lib, drinking-water were fed about 50 days, two groups of body weight obvious differences (P＜0.05), fat model forms.Choose 40 of the bigger and approaching rats of body weight then from fat model group, design according to dosage is divided into four groups after weighing, and joins combination group respectively, Folium Ilicis group, Semen Cassiae group and distilled water.Feed high lipid food 30 days continuously, rat is put to death, weigh and the body fat weight in wet base, calculate fat body ratio.The experimental data statistics adopts Excel-98 to do variance analysis.The results are shown in Table 2,3 and 4.
Table 1: the variation (X ± SD) that gives rat body weight before and after the high lipid food
| Group | Mus is counted the whole heavily weightening finish of starting weight (g) (g) (g) |
| Normal diet group high lipid food group | ????10????76.5±9.3??210.5±32.6?????134±28.6 ????40????76.3±9.1??293.2±49.8????216.9±40.2 |
| The P value | ?????????????1.00????????0.00??????????0.00 |
Table 1 data show that high fat group and common group of body weight have significant difference (T check, P＜0.05), fat model modeling success.
Table 2: (X ± SD) group dosage Mus number test precursor retry is tested the back weight gain to give respectively to organize the dosage influence to rat body weight in 30 days
G/Kg (g) be (g) blank group 10 293.2 ± 44.3 420.8 ± 55.3 127.6 ± 20.6 combination group 0.67 10 293.4 ± 43.2 336.1 ± 48.9 (g)
*42.7 ± 14.5
*Folium Ilicis group 1.34 10 293.0 ± 46.9 368.1 ± 50.2
*75.1 ± 16.7
*Semen Cassiae group 1.34 10 293.3 ± 46.7 398.6 ± 54.3 Δ 105.3 ± 18.9 Δs
*Representative is compared P＜0.05 with matched group; Δ is represented and is united group contrast P＜0.05.
Data show and join combination group in the table 2, and the mice body weight of Folium Ilicis group and Semen Cassiae group has than matched group and alleviates, and difference has significance (P＜0.05), but with Folium Ilicis and Semen Cassiae connection combination group alleviate at most and difference the most remarkable.
Table 3: (X ± SD) group dosage Mus number is tested back weight and body lactone body ratio to give the influence to the rat body fat in 30 days of each dosage group
G/Kg is (g) fatty weight in wet base (fat/100g body weight) blank group 10 420.8 ± 55.3 14.15 ± 2.16 3.36 ± 0.70 combination group 0.67 10 336.1 ± 48.9 6.89 ± 1.12 only
*2.05 ± 0.44
*Folium Ilicis group 1.34 10 368.1 ± 50.2 8.951 ± 1.46
*2.43 ± 066
*Semen Cassiae group 1.34 10 398.6 ± 54.3 10.88 ± 1.87 Δ 2.73 ± 0.79 Δs
*Representative is compared P＜0.05 with matched group; Δ is represented and is united group contrast P＜0.05.
Table 3 data show that the mice body fat weight in wet base and the fat body of each dosage group relatively have minimizing than with matched group, and difference has significance (P＜0.05), but with the mice weight in wet base of Folium Ilicis and Semen Cassiae connection combination group and body fat than reduce significantly and difference the most remarkable.
Conclusion: above-mentioned experiment shows that the coupling of Semen Cassiae and Folium Ilicis is used in to alleviate on the fat model of mice with Semen Cassiae or Folium Ilicis list to be compared, and Semen Cassiae and Folium Ilicis coupling have remarkable synergism.
Claims (10)
1. be used to reduce the overweight or fat compositions of weight of mammal, it comprises the plant Semen Cassiae, plant Folium Ilicis and usual excipients or carrier.
2. be used to reduce the overweight or fat compositions of weight of mammal, it is characterized in that: the coupling of Semen Cassiae of plant and plant Folium Ilicis.
3. claim 1 or 2 compositions, wherein the weight ratio between Semen Cassiae and the Folium Ilicis is 1: 9-9: 1.
4. claim 1 or 2 compositions, wherein the weight ratio between Semen Cassiae and the Folium Ilicis is 1: 5-5: 1.
5. claim 1 or 2 compositions, wherein the weight ratio between Semen Cassiae and the Folium Ilicis is 2: 1.
6. the compositions of the arbitrary requirement of claim 1-5, wherein compositions is an oral liquid, tablet, soft capsule or form of hard gelatin capsules.
7. the compositions of the arbitrary requirement of claim 1-5, wherein Semen Cassiae is to use with the water extract of Semen Cassiae mature seed or with the miscible extractive with organic solvent form of water.
8. the compositions of the arbitrary requirement of claim 1-5, wherein Folium Ilicis is to use with the water extract of Ilex latifolia tea-leaf or with the form of extract of the miscible organic solvent of water.
9. claim 7 or 8 compositions, wherein said Semen Cassiae or Folium Ilicis with the miscible extractive with organic solvent of water be the ethanol extraction of Semen Cassiae or Folium Ilicis.
10. Semen Cassiae and Folium Ilicis are united and are used to prepare the purposes that is used to reduce the overweight or fat compositions of the weight of animals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011048913A CN1186030C (en) | 2001-02-28 | 2001-02-28 | Composition for losing weight of mammal |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011048913A CN1186030C (en) | 2001-02-28 | 2001-02-28 | Composition for losing weight of mammal |
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| Publication Number | Publication Date |
|---|---|
| CN1372942A true CN1372942A (en) | 2002-10-09 |
| CN1186030C CN1186030C (en) | 2005-01-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011048913A Expired - Lifetime CN1186030C (en) | 2001-02-28 | 2001-02-28 | Composition for losing weight of mammal |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670927A (en) * | 2012-04-27 | 2012-09-19 | 太原市澳意医药生物科技有限公司 | Aloe dietary fiber capsule |
| CN107898763A (en) * | 2017-12-01 | 2018-04-13 | 大新县科学技术情报研究所 | A kind of common bombax flower Ilex Latifolia Thunb healthy effervescent tablet and preparation method thereof |
-
2001
- 2001-02-28 CN CNB011048913A patent/CN1186030C/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670927A (en) * | 2012-04-27 | 2012-09-19 | 太原市澳意医药生物科技有限公司 | Aloe dietary fiber capsule |
| CN107898763A (en) * | 2017-12-01 | 2018-04-13 | 大新县科学技术情报研究所 | A kind of common bombax flower Ilex Latifolia Thunb healthy effervescent tablet and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1186030C (en) | 2005-01-26 |
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Assignee: Hangzhou Yangshengtang Health-Care Product Co., Ltd. Assignor: Yangshengtang Co., Ltd Contract record no.: 2010330002160 Denomination of invention: Composition for losing weight of mammal Granted publication date: 20050126 License type: Exclusive License Open date: 20021009 Record date: 20101117 |
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Granted publication date: 20050126 |
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