CN1370528A - Medicine for treating insomnia and mental disturbance - Google Patents
Medicine for treating insomnia and mental disturbance Download PDFInfo
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- CN1370528A CN1370528A CN 01107147 CN01107147A CN1370528A CN 1370528 A CN1370528 A CN 1370528A CN 01107147 CN01107147 CN 01107147 CN 01107147 A CN01107147 A CN 01107147A CN 1370528 A CN1370528 A CN 1370528A
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Abstract
The present invention discloses the new application of natural compound tea polyphenol and its oxide tea pigment in preparing medicine and health article for treating insomnia and mental disturbances including neurosis, depression and nervousness. Tea polyphenol and its oxide tea pigment can be used to cure to relief the symptoms of the said diseases.
Description
The present invention relates to the new medicine use of tea polyphenols and oxide thereof (tea pigment), be specifically related to tea polyphenols and oxide thereof (tea pigment) and be used to prepare medicine and/or health product for treating insomnia, spirit and mental maladjustment disease, especially the catatonic application of Cure for insomnia, neurosis, depression and spirit and cranial nerve belongs to the field of Chinese medicines.
Tea polyphenols is the polyphenols that particularly extracts from Folium Camelliae sinensis from the plant Camellia sinensis, comprise more than 30 kind of polyphenol components such as catechin, flavonoid glycosides, cyanine glycoside, phenolic acids, belonging to the phenolic hydroxyl group natural phenolic compound, is the complex of natural phenolic compound, has stronger antioxygenic property.For the existing bibliographical information of the research of tea polyphenols.Multiple patent applications such as CN1142481A, CN1194966A, CN1186717A, CN1060488A, CN1071660A, CN1071844A, CN1056679A disclose the extracting method of tea polyphenols.Tea polyphenols mainly contains catechin, catechin accounts for 70% to 80% of tea polyphenols substantially, its oxidation product and/or half oxidation product promptly are tea pigments, are made up of theaflavin, thearubigins, abrownin, comprise the single composition and the complex of theaflavin and/or thearubigins and/or abrownin.The preparation method of tea pigment is tea polyphenols can be placed the air certain hour, autoxidation or half oxidation generation tea pigment; Also tea polyphenols heating soluble in water can be made its oxidation or half oxidation, generate tea pigment; Also can from Folium Camelliae sinensis, extract with patent application disclosed methods such as CN1081575A, CN1074459A, CN1074618A.With these methods with can be used as medicinal with tea polyphenols and oxide (tea pigment) thereof that additive method obtains.Medical value report for tea polyphenols and oxide (tea pigment) thereof may be summarized to be antitumor, blood fat reducing, blood sugar lowering, blood pressure lowering, cholesterol reducing, atherosclerosis, prevention and treatment cardiovascular disease.But up to the present, relevant tea polyphenols of Shang Weijian and oxide (tea pigment) thereof are used for the treatment of insomnia, spirit and mental maladjustment disease, especially Cure for insomnia, neurosis, depression and spirit and the catatonic report of cranial nerve.
The applicant with regard to tea polyphenols and oxide (tea pigment) is used for the treatment of insomnia, spirit and mental maladjustment disease, especially insomnia, neurosis, depression and spirit and the cranial nerve catatonia has been carried out long research, thereby has finished the present invention.
A kind of new medicinal usage that the purpose of this invention is to provide tea polyphenols and oxide thereof (tea pigment), be that tea polyphenols and oxide thereof (tea pigment) are used to prepare medicine or health product for treating insomnia, spirit and mental maladjustment disease, especially Cure for insomnia, neurosis, depression and spirit and the catatonic new application of cranial nerve.
Modern society's rhythm is fast, dog-eat-dog, and life is nervous, many people will face the problem of various survival and development, handle various contradictions, cause insomnia, spirit and mental maladjustment disease, especially insomnia, neurosis, depression and spirit and cranial nerve catatonia easily.These diseases are to be summed up as spirit and mental maladjustment from medical science, difficult the treatment, and become commonplace problem.
Neurosis claims neurosis again, is relevant with socio-psychological factors and characteristics of personality, does not have organic pathology basis, and the patient has one group of light-duty mental disorder of suitable insight to disease.Comprise neurasthenia, obsession, hysteria, anxiety neurosis, phobia, depressive neurosis.Depression is a kind of mental illness, often show as feel depressed, heart depression, performance are sluggish, some people then is that performance is intense, the somebody then has illusion, hallucination.Neurosis and depression all can cause insomnia, sleep disorder, spirit and cranial nerve anxiety.
Because this class disease does not have organic pathological changes, generally treats than refractory.Present this class disease of Drug therapy is respectively with amitriptyline, doxepin, Clomipramine, maprotiline, Paroxetine, sulpiride, fluorine west fourth, chlordiazepoxide, stable etc.But the Western medicine side effect is obvious, and Chinese medicine is few, and the Chinese medicine curative effect differs, and therapeutic effect is also slower.Therefore, seek a kind of to insomnia, spirit and mental maladjustment disease, especially it is very important insomnia, neurosis, depression and spirit and cranial nerve catatonia being had the natural drug of better therapeutic effect, and tea polyphenols and oxide thereof (tea pigment) have excellent curative in this respect.
Tea polyphenols of the present invention and oxide thereof (tea pigment) have multiple preparation method, belong to already known processes and mature technology, and existing commodity selling.
Tea polyphenols of the present invention and oxide thereof (tea pigment) are a kind of active constituents of medicine, preparation process according to routine, can be main active constituent with tea polyphenols and/or Tea pigment (tea pigment), add excipient substances such as conventional excipient, flavoring agent, disintegrating agent, antiseptic, lubricant, wetting agent, binding agent, solvent, thickening agent, solubilizing agent, make any dosage form that is suitable for using clinically, as tablet, capsule, granule, oral liquid, injection etc.
Tea polyphenols of the present invention and oxide thereof (tea pigment) are made medicine and/or health product, and the content of tea polyphenols and/or tea pigment can from 1% to 100% wait in medicine and/or the health product, generally adopts 20% to 90%.
Tea polyphenols of the present invention and oxide thereof (tea pigment) Cure for insomnia, spirit and mental maladjustment disease, especially Cure for insomnia, neurosis, depression and spirit and cranial nerve catatonia, available multiple administering mode, as oral, as external, transdermal, injection, rectum or parenterai administration.
Because the present invention discloses tea polyphenols and oxide (tea pigment) Cure for insomnia, spirit and mental maladjustment disease first; especially the catatonic pharmacologic action of Cure for insomnia, neurosis, depression, spirit and cranial nerve; therefore; tea polyphenols and/or Tea pigment (tea pigment) are cooperated the making medicament separately or with other active constituent or adjuvant; as long as this medicament is used for the treatment of insomnia, spirit and mental maladjustment disease; especially Cure for insomnia, neurosis, depression and spirit and cranial nerve catatonia then belong to protection scope of the present invention.
Tea polyphenols of the present invention and oxide thereof (tea pigment) all have Cure for insomnia, spirit and mental maladjustment disease, especially Cure for insomnia, neurosis, depression and spirit and the catatonic effect of cranial nerve when making any dosage form.Any medicament; if contain tea polyphenols and/or tea pigment in its component or only prepare patent medicine with tea polyphenols and/or tea pigment; on signs such as its packing or description; and on other any propaganda materials; as long as indicate or point out and have Cure for insomnia, spirit and mental maladjustment disease; especially the catatonic effect of Cure for insomnia, neurosis, depression and spirit and cranial nerve then falls within protection scope of the present invention.
Tea polyphenols of the present invention and oxide thereof (tea pigment) derive from the particularly natural plants Folium Camelliae sinensis of medicine-food two-purpose of plant Camellia sinensis, therefore, tea polyphenols and/or tea pigment can be made health food or health care medicine.Health food or the health care medicine made with tea polyphenols and/or tea pigment; if on signs such as its packing or description, indicate or point out and have Cure for insomnia, spirit and mental maladjustment disease; especially the catatonic effect of Cure for insomnia, neurosis, depression and spirit and cranial nerve also falls within protection scope of the present invention.
Embodiment 1
Prescription
Tea polyphenols (and/or tea pigment) 800 grams
Medical starch 200 grams
Above-mentioned component is stirred, encapsulated, every filling 0.5 gram.Make 2000 of tea polyphenols (and/or tea pigment) capsules, every capsules contains 400 milligrams of tea polyphenols (and/or tea pigment).
Embodiment 2
Tea polyphenols 250 grams
2000 milliliters of distilled water
Stevioside 1 gram
Tea polyphenols is dissolved in stirring and evenly mixing in the distilled water, adds stevioside, stirring and evenly mixing is bottled once more, and every bottled 10 milligrams, sterilization makes the tea polyphenols oral liquid.
Embodiment 3
Prescription
Tea polyphenols 15 grams
White sugar 50 grams
Citric acid 5 grams
Carbonated water 930 grams
A small amount of Herba Menthae, vanilla
Various raw materials are mixed, stir, bottle, make the tea polyphenols beverage.
Tea polyphenols of the present invention and oxide thereof (tea pigment) can improve insomnia, spirit and mental maladjustment disease, especially insomnia, neurosis, depression and spirit and cranial nerve catatoniac's symptom, treat various insomnias, spirit and mental maladjustment disease, especially Cure for insomnia, neurosis, depression and spirit and cranial nerve catatonia.Take the medicine of tea polyphenols of the present invention and oxide thereof (tea pigment) preparation,, especially insomnia, neurosis, depression and spirit and cranial nerve catatonia are had good curative effect insomnia, spirit and mental maladjustment disease.According to age, body weight, condition of illness, patient takes 0.5-1.5 gram tea polyphenols and/or tea pigment at every turn, every day three times, after meal or take one and a half hours ante cibum, positive effect was promptly arranged in several days, symptom is eased, and the February of taking medicine is to half a year, the patient with slight symptoms cures substantially or near curing, the patient with severe symptoms significantly takes a turn for the better.
The present invention has enlarged the range of application of tea polyphenols and oxide (tea pigment) thereof, has improved its exploitation and has been worth.With tea polyphenols of the present invention and oxide (tea pigment) Cure for insomnia, spirit and mental maladjustment disease, especially Cure for insomnia, neurosis, depression and spirit and cranial nerve catatonia, special effect, remarkable, compound method is simple, raw material is easy to get, and does not see toxic and side effects after taking.
Claims (12)
1, a kind of new purposes of making the medicine and/or the health product of raw material with tea polyphenols and/or Tea pigment (tea pigment), it is characterized in that tea polyphenols and/or Tea pigment (tea pigment) are cooperated making medicine and/or health product separately or with other drug active constituent or adjuvant, be used for the treatment of insomnia, spirit and mental maladjustment disease.
2, purposes according to claim 1 is characterized in that described tea polyphenols is the phenolic hydroxyl group natural phenolic compound that particularly extracts from the plant Camellia sinensis from Folium Camelliae sinensis, be the complex of natural phenolic compound, comprises multiple phenols composition, mainly contains catechin.
3, purposes according to claim 1 is characterized in that described tea pigment is the oxide and/or half oxide of tea polyphenols, is made up of theaflavin, thearubigins, abrownin, comprises the single composition and the complex of theaflavin and/or thearubigins and/or abrownin.
4, purposes according to claim 1, the content that it is characterized in that tea polyphenols in medicine and/or the health product is 1% to 100%.
5, purposes according to claim 1, the content that it is characterized in that tea pigment in medicine and/or the health product is 1% to 100%.
6, purposes according to claim 4, the content that it is characterized in that tea polyphenols in medicine and/or the health product is 20% to 90%.
7, purposes according to claim 5, the content that it is characterized in that tea pigment in medicine and/or the health product is 20% to 90%.
8, purposes according to claim 1 is characterized in that being used for the treatment of the insomnia.
9, purposes according to claim 1 is characterized in that being used for the treatment of neurosis, comprises neurasthenia, obsession, hysteria, anxiety neurosis, phobia, depressive neurosis.
10, purposes according to claim 1 is characterized in that being used for the treatment of depression.
11, purposes according to claim 1 is characterized in that being used for the treatment of spirit and cranial nerve catatonia.
12,, purposes according to claim 1, it is characterized in that oral administration, external, transdermal, injection, rectum or parenterai administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01107147 CN1370528A (en) | 2001-02-21 | 2001-02-21 | Medicine for treating insomnia and mental disturbance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01107147 CN1370528A (en) | 2001-02-21 | 2001-02-21 | Medicine for treating insomnia and mental disturbance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1370528A true CN1370528A (en) | 2002-09-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01107147 Pending CN1370528A (en) | 2001-02-21 | 2001-02-21 | Medicine for treating insomnia and mental disturbance |
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| CN (1) | CN1370528A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352801A (en) * | 2014-10-27 | 2015-02-18 | 哈尔滨金玉科技开发有限公司 | Traditional Chinese medicine for treating hypochondriasis and preparation method thereof |
| CN108463234A (en) * | 2016-01-28 | 2018-08-28 | 花王株式会社 | The glucose metabolism activator of astroglia |
| CN108926554A (en) * | 2018-10-12 | 2018-12-04 | 中国科学院昆明植物研究所 | Application of the catechin in preparation treatment central nervous system disease drug |
-
2001
- 2001-02-21 CN CN 01107147 patent/CN1370528A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352801A (en) * | 2014-10-27 | 2015-02-18 | 哈尔滨金玉科技开发有限公司 | Traditional Chinese medicine for treating hypochondriasis and preparation method thereof |
| CN108463234A (en) * | 2016-01-28 | 2018-08-28 | 花王株式会社 | The glucose metabolism activator of astroglia |
| US10925919B2 (en) | 2016-01-28 | 2021-02-23 | Kao Corporation | Agent for activating astrocyte glucose metabolism |
| CN108926554A (en) * | 2018-10-12 | 2018-12-04 | 中国科学院昆明植物研究所 | Application of the catechin in preparation treatment central nervous system disease drug |
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| WD01 | Invention patent application deemed withdrawn after publication |