CN1314149A - New use of tea polyphenols and its oxide for treating hepatopathy - Google Patents
New use of tea polyphenols and its oxide for treating hepatopathy Download PDFInfo
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- CN1314149A CN1314149A CN00112774A CN00112774A CN1314149A CN 1314149 A CN1314149 A CN 1314149A CN 00112774 A CN00112774 A CN 00112774A CN 00112774 A CN00112774 A CN 00112774A CN 1314149 A CN1314149 A CN 1314149A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
Tea polyphenol and its oxide (tawny extract) are used to prepare medicine and health product for treating hepatopathy, especially new medicine for treating viral hepatitis and hepatocirrhosis. They may be used to cure or remit hepatopathy.
Description
The present invention relates to the new medicine use of tea polyphenols and oxide thereof (tea pigment), be specifically related to the application that tea polyphenols and oxide thereof (tea pigment) are used to prepare medicine or health product for treating hepatic disease, belong to the field of Chinese medicines.
Tea polyphenols is the polyphenols that extracts from Folium Camelliae sinensis, comprises more than 30 kind of polyphenol components such as catechin, flavonoid glycosides, cyanine glycoside, phenolic acids, has stronger antioxygenic property.For the existing bibliographical information of the research of tea polyphenols.Multiple patent applications such as CN1142481A, CN1194966A, CN1186717A, CN1060488A, CN1071660A, CN1071844A, CN1056679A disclose the extracting method of tea polyphenols.The main body of tea polyphenols is a catechin, accounts for 70% to 80% of tea polyphenols substantially, and its oxidation product promptly is a tea pigment, comprises theaflavin, thearubigins and abrownin.The preparation method of tea pigment is tea polyphenols can be placed the air certain hour, autoxidation generation tea pigment; Also tea polyphenols heated oxide soluble in water can be generated tea pigment; Also can from Folium Camelliae sinensis, extract with patent application disclosed methods such as CN1081575A, CN1074459A, CN1074618A.The tea polyphenols and the oxide (tea pigment) thereof that obtain with these methods can be used as medicinal.Medical value report for tea polyphenols and oxide (tea pigment) thereof may be summarized to be antitumor, blood fat reducing, blood sugar lowering, blood pressure lowering, cholesterol reducing, atherosclerosis, prevention and treatment cardiovascular disease.But up to the present, relevant tea polyphenols of Shang Weijian and oxide (tea pigment) thereof are used for the treatment of the hardened report of viral hepatitis regulating liver-QI.
The present inventor is used for the treatment of hepatic disease with regard to tea polyphenols and oxide (tea pigment) thereof and has carried out long research, thereby finished the present invention.
A kind of new medicinal usage that the purpose of this invention is to provide tea polyphenols and oxide thereof (tea pigment), be that tea polyphenols and oxide thereof (tea pigment) are used to prepare medicine or health product for treating hepatic disease, particularly treat the hardened new purposes of viral hepatitis regulating liver-QI.
Hepatic disease comprises viral hepatitis and liver cirrhosis etc., and viral hepatitis is divided into first type, B-mode and non-a, non-b type again.Hepatic disease is common disease, and especially viral hepatitis is popular wider infectious disease.Hepatitis heating, weak, anorexia, feel sick, hepatomegaly, hepatalgia, abdominal distention, liver function injury, obstinate can cause liver cirrhosis and hepatocarcinoma; Liver cirrhosis is the long-term or impaired repeatedly liver structure reconstruction that causes of liver, liver distortion, hardening, is divided into portal cirrhosis, postnecrotic cirrhosis, biliary cirrhosis and parasitic liver cirrhosis etc., is common with portal cirrhosis.The function of detoxification and the metabolism of ill back liver are affected, and especially late period, liver dwindles hardening, splenomegaly, and splenic function resists into, edema, ascites, hepatic coma, disturbances of blood coagulation, complexion be gloomy, become thin, anemia.Western medical treatment hepatitis is used vitamins, glucose, Energy mixture, enzyme, prohepar, hormone, interferon and inducer always at present, treatment liver cirrhosis yeast tablet commonly used, compound vitamin, glucuronolatone, dissopropylamine ascorbate etc.Except that interferon and inducer effect better, the other drug curative effect differs, but interferon and inducer output little, cost an arm and a leg.Chinese traditional treatment at present, adaptive surface is too wide, is difficult to timely disease controlling, also is difficult to remove old complaint.For viral hepatitis and liver cirrhosis, still lack effective and inexpensive radical cure medicine.Therefore, seek a kind ofly to hepatic disease, particularly the natural drug that viral hepatitis and liver cirrhosis are had a remarkable therapeutic effect is very important, and tea polyphenols and oxide thereof (tea pigment) have been obtained excellent curative in this respect.
Tea polyphenols of the present invention and oxide thereof (tea pigment) have multiple preparation method, belong to already known processes and mature technology, and existing commodity selling.
Tea polyphenols of the present invention and oxide thereof (tea pigment) are a kind of active constituents of medicine, preparation process according to routine, can be main active constituent with tea polyphenols and/or Tea pigment (tea pigment), add excipient substances such as conventional excipient, flavoring agent, disintegrating agent, antiseptic, lubricant, wetting agent, binding agent, solvent, thickening agent, solubilizing agent, make any dosage form that is suitable for using clinically, as tablet, capsule, granule, oral liquid, injection etc.
Because the present invention discloses tea polyphenols and oxide (tea pigment) treatment hepatic disease thereof first; particularly treat the hardened pharmacologic action of viral hepatitis regulating liver-QI; therefore; tea polyphenols and/or Tea pigment (tea pigment) are cooperated the making medicament separately or with other active constituent or adjuvant; as long as this medicament is used for the treatment of hepatic disease; especially for treatment viral hepatitis and liver cirrhosis, all belong to protection scope of the present invention.
Tea polyphenols of the present invention and oxide thereof (tea pigment) all have the effect of treatment hepatic disease when making any dosage form.Any medicament; if contain tea polyphenols and/or tea pigment in its component or only prepare patent medicine with tea polyphenols and/or tea pigment; on signs such as its packing or description; and on other any propaganda materials; as long as indicate or point out and have the treatment hepatic disease; the hardened effect of treatment viral hepatitis regulating liver-QI is particularly arranged, then fall within protection scope of the present invention.
Tea polyphenols of the present invention and oxide thereof (tea pigment) derive from the natural plants Folium Camelliae sinensis of medicine-food two-purpose, therefore, tea polyphenols and/or tea pigment can be made health food or health care medicine.Health food or the health care medicine made with tea polyphenols and/or tea pigment; if on signs such as its packing or description, indicate or point out and have the treatment hepatic disease; the hardened effect of treatment viral hepatitis regulating liver-QI is particularly arranged, also fall within protection scope of the present invention.
Embodiment 1
Prescription
Tea polyphenols 800 grams
Medical starch 200 grams
Above-mentioned component is stirred, encapsulated, every filling 0.5 gram.Make 2000 of tea polyphenols capsules, every capsules contains 400 milligrams of tea polyphenols.
Embodiment 2
Tea polyphenols 250 grams
2000 milliliters of distilled water
Stevioside 1 gram
Tea polyphenols is dissolved in stirring and evenly mixing in the distilled water, adds stevioside, stirring and evenly mixing is bottled once more, and every bottled 10 milligrams, sterilization makes the tea polyphenols oral liquid.
Embodiment 3
Prescription
Tea polyphenols 15 grams
White sugar 50 grams
Citric acid 5 grams
Carbonated water 930 grams
A small amount of Herba Menthae, vanilla
Various raw materials are mixed, stir, bottle, make the tea polyphenols beverage.
The medicine of tea polyphenols of the present invention and oxide thereof (tea pigment) preparation is taken checking through 45 routine patients, and to hepatic disease, particularly viral hepatitis and liver cirrhosis all have good curative effect.According to age, body weight, condition of illness, patient takes 0.5-1.2 gram tea polyphenols and/or tea pigment at every turn, every day three times, after meal or take one and a half hours ante cibum, promptly there was positive effect in two weeks, the heating of hepatitis, weak, anorexia, feel sick, symptom such as hepatalgia obviously alleviates, the pathological changes of early metaphase liver cirrhosis patient is controlled.Take medicine half a year to one year, slight hepatitis and liver cirrhosis patient is almost recovered or near recovery from illness, the various symptoms of patient with severe symptoms significantly take a turn for the better, it is normal that liver function is recovered gradually.Take tea polyphenols of the present invention and oxide thereof (tea pigment) treatment hepatic disease, particularly treat viral hepatitis and liver cirrhosis, total effective rate 98%, obvious effective rate is more than 92%.
The present invention has enlarged the range of application of tea polyphenols and oxide (tea pigment) thereof, has improved its exploitation and has been worth.With tea polyphenols of the present invention and oxide (tea pigment) thereof treatment hepatic disease, particularly treat viral hepatitis and liver cirrhosis, special effect, significantly, compound method is simple, do not see toxic and side effects after taking.
Claims (10)
1, a kind of new purposes of making the medicine or the health product of raw material with tea polyphenols and/or Tea pigment (tea pigment), it is characterized in that tea polyphenols and/or Tea pigment (tea pigment) are cooperated making medicine or health product separately or with other drug active constituent or adjuvant, be used for the treatment of the new purposes of hepatic disease.
2,, it is characterized in that being used to the virus hepatitis of curing the disease according to the purposes of claim 1.
3,, it is characterized in that being used for the treatment of liver cirrhosis according to the purposes of claim 1.
4,, it is characterized in that being used for the treatment of hepatitis A according to the purposes of claim 2.
5,, it is characterized in that being used for the treatment of hepatitis B according to the purposes of claim 2.
6,, it is characterized in that being used for the treatment of viral hepatitis non-A non-B according to the purposes of claim 2.
7,, it is characterized in that being used for the treatment of portal cirrhosis according to the purposes of claim 3.
8,, it is characterized in that being used for the treatment of postnecrotic cirrhosis according to the purposes of claim 3.
9,, it is characterized in that being used for the treatment of biliary cirrhosis according to the purposes of claim 3.
10,, it is characterized in that being used for the treatment of the parasitic liver cirrhosis according to the purposes of claim 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00112774A CN1314149A (en) | 2000-03-20 | 2000-03-20 | New use of tea polyphenols and its oxide for treating hepatopathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00112774A CN1314149A (en) | 2000-03-20 | 2000-03-20 | New use of tea polyphenols and its oxide for treating hepatopathy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1314149A true CN1314149A (en) | 2001-09-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00112774A Pending CN1314149A (en) | 2000-03-20 | 2000-03-20 | New use of tea polyphenols and its oxide for treating hepatopathy |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100432219C (en) * | 2006-07-28 | 2008-11-12 | 浙江大学 | Cow ovum cell in vitro ripening culturing liquid containing tea polyphenol and its culturing method |
| CN100534426C (en) * | 2004-05-28 | 2009-09-02 | 养生堂有限公司 | Novel use of chromene compound |
-
2000
- 2000-03-20 CN CN00112774A patent/CN1314149A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100534426C (en) * | 2004-05-28 | 2009-09-02 | 养生堂有限公司 | Novel use of chromene compound |
| CN100432219C (en) * | 2006-07-28 | 2008-11-12 | 浙江大学 | Cow ovum cell in vitro ripening culturing liquid containing tea polyphenol and its culturing method |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |