CN1367002A - Pure Chinese medicine for giving up drugs and its preparation method - Google Patents
Pure Chinese medicine for giving up drugs and its preparation method Download PDFInfo
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- CN1367002A CN1367002A CN 02109158 CN02109158A CN1367002A CN 1367002 A CN1367002 A CN 1367002A CN 02109158 CN02109158 CN 02109158 CN 02109158 A CN02109158 A CN 02109158A CN 1367002 A CN1367002 A CN 1367002A
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Abstract
The present invention discloses a pure Chinese medicine for stopping drugs and its preparation method. It is made up by using the Chinese medicinal materials of ledum palustre L, var, dilatatum, ledum palustre L. var, angustum, pueraria root, notopterygium root, dried ginger, lycium berry, schisandra berry and acanthopanax root through a refined extraction process. Its therapeutic effect is obvious, its has no toxic side effect, and can raise immunological function of high so as to can obtain complete withdrawal effect.
Description
Technical field
The present invention relates to a kind of drug-breaking medicine, anti-additive medicament that particularly a kind of pure Chinese herbal medicine is made and preparation method thereof.
Background technology
Drug abuse is the ubiquitous a kind of hateful phenomenons in countries in the world.Strengthening management all over the world, but the drug abuse phenomenon exists still, also relate to China inevitably, the number that a few years is taken drugs increases day by day, has become serious social concern now.So-called drugs are morphine and non-morphinoid derivatives (II) things such as heroin, cocaine, morphine, Fructus Cannabis, Opium, and these drugs can be anaesthetized cerebral cortex, make the people glad and hallucination arranged, this and very easily produce hobby and habit-forming.Cause body constitution to descend after the junkie addiction, resistance against diseases reduces, and spleen, stomach, liver, kidney all sustain damage, and junkie is declined lose life and work capacity, brings disturbance factor to society.
In recent years, China's anti-additive medicament is developed in succession, as methadone oral liquid and clonidine etc., but these chemical synthetic drugs have bigger side effect or untoward reaction, and disconnected medicine is difficult, the patient often leaves symptoms such as general power cold syndrome of the stomach, weak sleepy, general pain osteodynia, nausea and vomiting after the drug withdrawal, is easy to cause patient to revert to take drugs once more.Given this, medium-height grass anti-additive medicaments such as Britlofex (lofexidine hydrochloride), FUKANG PIAN have appearred, but from the drug effect of clinical treatment, still unsatisfactory, and cost an arm and a leg, general patient is difficult to bear economically.
Summary of the invention
The purpose of this invention is to provide a kind of medicine and preparation method thereof of pure Chinese medicinal preparation of the system addiction of can effectively quitting drug abuse, its curative effect of medication is remarkable, and curative effect is short, and instant effect has no side effect, and price comparison is cheap, and the non-narcotic anti-additive medicament of enhancing human body immunity function.
Technical solution of the present invention is as follows:
Medicine of the present invention is made by the Chinese crude drug of following component:
Ledum palustre Linn. var. dilatatum Wahlanberg: 60-80 weight portion Folium Ledi Angusti: 20-40 weight portion
Radix Puerariae: 6-12 weight portion Rhizoma Et Radix Notopterygii: 12-25 weight portion
Rhizoma Zingiberis: 4-10 weight portion Fructus Lycii: 2-5 weight portion
Fructus Schisandrae Chinensis: 12-25 weight portion Radix Et Caulis Acanthopanacis Senticosi: 6-12 weight portion
The preparation method of invention is as follows:
(1) Ledum palustre Linn. var. dilatatum Wahlanberg and Folium Ledi Angusti are pressed the pressurization steam distillation, temperature with 0.5Kg-1Kg pressure and 100 ℃-150 ℃, extracted 1-1.5 hour, isolate subnatant with separator, subnatant chloroform extraction then, the ratio of medicinal liquid and chloroform is 20-30: 1, left standstill 30 minutes, separate 70 ℃-75 ℃ of chloroform layer heating then, remaining medicinal liquid is stand-by;
(2) Chinese crude drugs such as Radix Puerariae, Rhizoma Et Radix Notopterygii, Rhizoma Zingiberis, the long-pending son of Chinese holly, Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi are mixed, adding water floods medical material, decocts 2 hours in water, stand-by behind the filtering and impurity removing;
(3) medicinal liquid of above-mentioned (1) gained is poured in the medicinal liquid of (2), mixed the back and become soft gelatin capsule to get final product with the fill of soft gelatin capsule machine.
Ledum palustre Linn. var. dilatatum Wahlanberg and Folium Ledi Angusti are the principal agents of this product with merit of the same race among the present invention, are to belong to ericad, and the astringing intestine to stop diarrhea of astringing the lung, two medicines can the detoxicating withdrawals, drive epidemic disease, antiinflammatory, are aided with conditioning, the body resistance strengthening and constitution consolidating, and the warming the meridian blood stasis dispelling has complementary function.
Medicine of the present invention has evident in efficacy, short treating period, instant effect, have no side effect advantage such as price comparison is cheap, shedding tears in the time of to make the heroin outbreak, watery nasal discharge, symptoms such as osteodynia stomachache dysphoria are controlled the drug rehabilitation no pain, and no dependence also has invigorating the spleen and replenishing QI, stomach warming pain relieving simultaneously, nourish blood tonifying liver, the kidney invigorating, reach the body constitution of comprehensive raising drug abstainer self, the enhancing human body immunity function, and realize the thoroughly effect of drug rehabilitation product.
The specific embodiment
Below in conjunction with embodiment, clinical case and zoopery example clinical case, medicine of the present invention is further explained.
Embodiment 1
Chinese crude drug by following component of the present invention is made;
Ledum palustre Linn. var. dilatatum Wahlanberg 60 weight portion Folium Ledi Angusti 40 weight portions
Radix Puerariae 6 weight portion Rhizoma Et Radix Notopterygiis 12 weight portions
Rhizoma Zingiberis 4 weight portion Fructus Lycii 2 weight portions
Fructus Schisandrae Chinensis 12 weight portion Radix Et Caulis Acanthopanacis Senticosis 6 weight portions
Preparation method of the present invention is as follows:
(1) Ledum palustre Linn. var. dilatatum Wahlanberg and Folium Ledi Angusti are pressed the temperature of pressure leaching process with 0.75Kg atmospheric pressure and 125 ℃, extracted 1.5 hours, tell subnatant with separator, subnatant chloroform extraction then, the ratio of medicinal liquid and chloroform is 25: 1, leaves standstill 30 minutes, separates chloroform layer then, 75 ℃ of heating chloroform layers, remaining medicinal liquid is stand-by;
(2) Radix Puerariae, Rhizoma Et Radix Notopterygii, Rhizoma Zingiberis, the long-pending son of Chinese holly, Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi were decocted in water 1 hour with decocting method, stand-by behind the filtering and impurity removing;
(3) medicinal liquid of above-mentioned (1) gained is poured in the medicinal liquid of (2), mixed the back and become soft gelatin capsule to get final product with the fill of soft gelatin capsule machine.
Embodiment 2
It is described identical with embodiment 1 that medicine of the present invention is made outer its preparation process by the Chinese crude drug of following component.
Ledum palustre Linn. var. dilatatum Wahlanberg 70 weight portion Folium Ledi Angusti 30 weight portions
Radix Puerariae 8 weight portion Rhizoma Et Radix Notopterygiis 18 weight portions
Rhizoma Zingiberis 6 weight portion Fructus Lycii 4 weight portions
Fructus Schisandrae Chinensis 18 weight portion Radix Et Caulis Acanthopanacis Senticosis 8 weight portions
Zoopery example: animal acute toxicity reaction of the present invention and maximum tolerated dose experiment
This experiment is undertaken by Medical College's pharmaceutical analysis institute.
Laboratory animal: Kunming mouse body weight: 18-20g male and female half and half
Experimental technique: get 40 mices, be divided into 4 groups at random, 10 every group, male and female half and half.The laboratory animal fasting is 12 hours before the administration, every group of dosage A group 0.073ml/20g; B organizes 0.157ml/20g; C organizes 0.338ml/20g; D organizes 0.73ml/20g.The gastric infusion feeding that supplies water after 30 minutes was observed 7 days continuously.First day D group mice is all dead after irritating stomach, all the other A, and B, the activity of C group is normal,
The result: first day D group mice is all dead after irritating stomach, all the other A, and B, the activity of C group is normal, and defecation is no abnormal, does not have death, finds no toxic reaction.Acute toxicity appears at (pressing body surface area calculates) between 80 to 100 times of human oral dosage.
Conclusion: the result shows in above-mentioned experiment, and the present invention is 80 times of clinical application amount to the maximum tolerated dose of laboratory animal mice administration, and toxicity of the present invention as can be known is very low, as safe as a house.
Medicine of the present invention " prolongs limit hospital of brain section " in calendar year 2001, units such as " the Yan Bian hospitals of traditional Chinese and western medicine " is the experimental drug name with " pill for narcotic abstinence ", carried out clinical experiment, provide administration by development person, per 12 hours once oral, each 1 (every content is 0.4ml), after taking medicine, its result comes into effect in 0.5 to 1 hour, symptoms such as very fast alleviation fear of cold coldness of the body, the watery nasal discharge of shedding tears, general pain osteodynia with about 7 days, are removed patient's drug addiction fully.
Clinical case:
Example 1 patient: Piao * *, the man, 40 years old, inhaled heroin from 1993, use 1g every day, divide five, six intravenous injections.
Through taking medicine of the present invention after 7 day course of treatment, to finish and give up, and in high spirits, appetite is normal, weak disappearance, up to the present drug addiction is not shown effect and is want desire complete obiteration with heroin.
Example 2 patients: Lee *, the man, 43 years old, inhaled heroin from 1996, use 1g every day, divide five, six intravenous injections.
Through taking medicine of the present invention after 7 day course of treatment, to finish and give up, and in high spirits, appetite is normal, weak disappearance, up to the present drug addiction is not shown effect and is want desire complete obiteration with heroin.
Show that through clinical experiment medicine of the present invention has no side effect, short treating period, instant effect, easy to use, do not produce dependency, particularly the whole immunologic function of recanalization body, treating both the principal and secondary aspects of a disease, cheap, it is acceptant to can be extensive patients.
Claims (3)
1, a kind of pure Narcotic Chinese medicine thing is characterized in that being made by the Chinese crude drug of following component:
Ledum palustre Linn. var. dilatatum Wahlanberg: 60-80 weight portion Folium Ledi Angusti: 20-40 weight portion
Radix Puerariae: 6-12 weight portion Rhizoma Et Radix Notopterygii: 12-2 5 weight portions
Rhizoma Zingiberis: 4-10 weight portion Fructus Lycii: 2-5 weight portion
Fructus Schisandrae Chinensis: 12-25 weight portion Radix Et Caulis Acanthopanacis Senticosi: 6-12 weight portion
2, the preparation method of pure Narcotic Chinese medicine thing according to claim 1 is characterized in that preparing according to the following steps:
(1) with Ledum palustre Linn. var. dilatatum Wahlanberg and Folium Ledi Angusti by the pressurization steam distillation, with the temperature of 0.5Kg-1Kg pressure and 100 ℃-150 ℃, extracted 1-1.5 hour, isolate subnatant with separator, the subnatant chloroform extraction heats 70 ℃-75 ℃ with chloroform layer then, and remaining medicinal liquid is stand-by;
(2) Radix Puerariae, Rhizoma Et Radix Notopterygii, Rhizoma Zingiberis, the long-pending son of Chinese holly, Fructus Schisandrae Chinensis, Radix Et Caulis Acanthopanacis Senticosi were decocted 2 hours with decocting method, stand-by behind the filtering and impurity removing;
(3) medicinal liquid of above-mentioned (1) gained is poured in the medicinal liquid of (2), made soft gelatin capsule after mixing and get final product;
3, the preparation method of pure Narcotic Chinese medicine thing as claimed in claim 2, when it is characterized in that using chloroform extraction, chloroform and extracting solution ratio are 1: 20-30.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021091587A CN1151834C (en) | 2002-02-04 | 2002-02-04 | Pure Chinese medicine for giving up drugs and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021091587A CN1151834C (en) | 2002-02-04 | 2002-02-04 | Pure Chinese medicine for giving up drugs and its preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN1367002A true CN1367002A (en) | 2002-09-04 |
| CN1151834C CN1151834C (en) | 2004-06-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021091587A Expired - Fee Related CN1151834C (en) | 2002-02-04 | 2002-02-04 | Pure Chinese medicine for giving up drugs and its preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703647B (en) * | 2009-11-20 | 2011-06-15 | 严千燮 | Anti-additive medicament and preparation method thereof |
| CN103181597A (en) * | 2012-09-25 | 2013-07-03 | 李善茂 | Ledum palustre detoxication health care liquid and preparation method thereof |
-
2002
- 2002-02-04 CN CNB021091587A patent/CN1151834C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703647B (en) * | 2009-11-20 | 2011-06-15 | 严千燮 | Anti-additive medicament and preparation method thereof |
| CN103181597A (en) * | 2012-09-25 | 2013-07-03 | 李善茂 | Ledum palustre detoxication health care liquid and preparation method thereof |
| CN103181597B (en) * | 2012-09-25 | 2014-10-29 | 许金禄 | Ledum palustre detoxication health care liquid and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1151834C (en) | 2004-06-02 |
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