CN1363326A - Nano method for making bone joint stronger and its preparing process - Google Patents
Nano method for making bone joint stronger and its preparing process Download PDFInfo
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- CN1363326A CN1363326A CN 01100763 CN01100763A CN1363326A CN 1363326 A CN1363326 A CN 1363326A CN 01100763 CN01100763 CN 01100763 CN 01100763 A CN01100763 A CN 01100763A CN 1363326 A CN1363326 A CN 1363326A
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Abstract
A nano medicine for making bone and joint stronger is prepared from the nano powders of 8 Chinese-medicinal materials including cibot rhizome epimedium, pubescent angelica root, aucklandia root, etc through proportioning, microwave extracting, vacuum concentrating and supersonic-jet spray drying. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of liver and kidney tonifying, nourshing blood and promoting blood circulation, dispelling wind and removing obstruction in the collateral, cure mainly the nanometer making bone joint stronger of lumbar vertebra, cervical vertebra, heel, extremities joint hyperosteogeny and lumbar muscle strain, the invention still further relates to the method for this medication preparation.
ZHUANGGU GUANJIE WAN is a kind of classical Chinese patent medicine, mainly contain analgesia, calmness, antiinflammatory, promotion RNA, DNA synthetic, increase effect such as myocardial nutritional flow amount, be used for lumbar vertebra, cervical vertebra, heel, extremities joint hyperosteogeny and lumbar muscle strain, but traditional ZHUANGGU GUANJIE WAN absorbs not exclusively, bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer making bone joint stronger of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer making bone joint stronger.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Rhizoma Cibotii 5-50 part nanometer Herba Epimedii 10-50 part nanometer Radix Angelicae Pubescentis 10-50 part
Nanometer Rhizoma Drynariae 10-50 part nanometer Radix Aucklandiae 10-50 part nanometer Caulis Spatholobi 10-60 part
Nanometer Radix Dipsaci 10-50 part nanometer Radix Rehmanniae Preparata 5-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Rhizoma Cibotii 10-30 part nanometer Herba Epimedii 15-40 part nanometer Radix Angelicae Pubescentis 20-40 part
Nanometer Rhizoma Drynariae 15-40 part nanometer Radix Aucklandiae 20-40 part nanometer Caulis Spatholobi 15-40 part
Nanometer Radix Dipsaci 20-40 part nanometer Radix Rehmanniae Preparata 10-30 part
The best important proportioning of medicine of the present invention is:
30 parts of 25 parts of nanometer Radix Angelicae Pubescentiss of 20 parts of nanometer Herba Epimedii of nanometer Rhizoma Cibotii
26 parts of 28 parts of nanometer Caulis Spatholobis of 25 parts of nanometer Radix Aucklandiae of nanometer Rhizoma Drynariae
20 parts in 30 parts of nanometer Radix Rehmanniaes Preparata of nanometer Radix Dipsaci
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get ZHUANGGU GUANJIE WAN preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nanometer making bone joint stronger is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common ZHUANGGU GUANJIE WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer making bone joint stronger etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for various arthropathic treatments, and clinical efficacy significantly is better than traditional ZHUANGGU GUANJIE WAN
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Radix Angelicae Pubescentiss of 20 parts of nanometer Herba Epimedii of nanometer Rhizoma Cibotii
26 parts of 28 parts of nanometer Caulis Spatholobis of 25 parts of nanometer Radix Aucklandiae of nanometer Rhizoma Drynariae
20 parts in 30 parts of nanometer Radix Rehmanniaes Preparata of nanometer Radix Dipsaci
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time every day, each 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Radix Angelicae Pubescentiss of 20 parts of nanometer Herba Epimedii of nanometer Rhizoma Cibotii
26 parts of 28 parts of nanometer Caulis Spatholobis of 25 parts of nanometer Radix Aucklandiae of nanometer Rhizoma Drynariae
20 parts in 30 parts of nanometer Radix Rehmanniaes Preparata of nanometer Radix Dipsaci
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer bone strengthening joint powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
30 parts of 25 parts of nanometer Radix Angelicae Pubescentiss of 20 parts of nanometer Herba Epimedii of nanometer Rhizoma Cibotii
26 parts of 28 parts of nanometer Caulis Spatholobis of 25 parts of nanometer Radix Aucklandiae of nanometer Rhizoma Drynariae
20 parts in 30 parts of nanometer Radix Rehmanniaes Preparata of nanometer Radix Dipsaci
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer bone strengthening joint membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nanometer making bone joint stronger is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Rhizoma Cibotii 5-50 part nanometer Herba Epimedii 10-50 part nanometer Radix Angelicae Pubescentis 10-50 part
Nanometer Rhizoma Drynariae 10-50 part nanometer Radix Aucklandiae 10-50 part nanometer Caulis Spatholobi 10-60 part
Nanometer Radix Dipsaci 10-50 part nanometer Radix Rehmanniae Preparata 5-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nanometer making bone joint stronger according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Rhizoma Cibotii 10-30 part nanometer Herba Epimedii 15-40 part nanometer Radix Angelicae Pubescentis 20-40 part
Nanometer Rhizoma Drynariae 15-40 part nanometer Radix Aucklandiae 20-40 part nanometer Caulis Spatholobi 15-40 part
Nanometer Radix Dipsaci 20-40 part nanometer Radix Rehmanniae Preparata 10-30 part
3, nanometer making bone joint stronger according to claim 1, wherein the weight proportion of each nano raw material is:
30 parts of 25 parts of nanometer Radix Angelicae Pubescentiss of 20 parts of nanometer Herba Epimedii of nanometer Rhizoma Cibotii
26 parts of 28 parts of nanometer Caulis Spatholobis of 25 parts of nanometer Radix Aucklandiae of nanometer Rhizoma Drynariae
20 parts in 30 parts of nanometer Radix Rehmanniaes Preparata of nanometer Radix Dipsaci
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nanometer making bone joint strongers.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer making bone joint strongers; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100763 CN1363326A (en) | 2001-01-09 | 2001-01-09 | Nano method for making bone joint stronger and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100763 CN1363326A (en) | 2001-01-09 | 2001-01-09 | Nano method for making bone joint stronger and its preparing process |
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| CN1363326A true CN1363326A (en) | 2002-08-14 |
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| CN 01100763 Pending CN1363326A (en) | 2001-01-09 | 2001-01-09 | Nano method for making bone joint stronger and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931277B (en) * | 2005-10-08 | 2011-04-06 | 华润三九医药股份有限公司 | Osteoarthrosis treating Chinese medicine composition and its preparation process |
-
2001
- 2001-01-09 CN CN 01100763 patent/CN1363326A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931277B (en) * | 2005-10-08 | 2011-04-06 | 华润三九医药股份有限公司 | Osteoarthrosis treating Chinese medicine composition and its preparation process |
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