CN1363293A - Nano medicine for treating baby cough and its preparing process - Google Patents
Nano medicine for treating baby cough and its preparing process Download PDFInfo
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- CN1363293A CN1363293A CN 01100216 CN01100216A CN1363293A CN 1363293 A CN1363293 A CN 1363293A CN 01100216 CN01100216 CN 01100216 CN 01100216 A CN01100216 A CN 01100216A CN 1363293 A CN1363293 A CN 1363293A
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Abstract
A nano antitussive medicine for infant is prepared from the nano powders of 4 raw materials including platycodon root fluid extract, ammonium chloride, etc through proportioning, microwave extracting, vacuum concentrating, and supersonic-jet spray drying. Its advantages include high biologic utilization rate and high curative effect.
Description
The present invention relates to a kind ofly to eliminate the phlegm, the nano medicine for treating baby cough of antitussive, the invention still further relates to the method for this medication preparation.
XIAOER ZHIKE TANGJIANG is a kind of classical Chinese patent medicine, mainly contain eliminate the phlegm, effect such as antitussive, be used for the diseases such as cough that infantile common cold causes.But traditional XIAOER ZHIKE TANGJIANG absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine for treating baby cough of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine for treating baby cough.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Glycyrrhizae fluid extract 100-200 part nanometer Radix Platycodonis fluidextract 20-45 part
Nanometer ammonium chloride 5-15 part nanometer Pericarpium Citri junoris tincture 10-35 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Glycyrrhizae fluid extract 120-180 part nanometer Radix Platycodonis fluidextract 25-35 part
Nanometer ammonium chloride 8-12 part nanometer Pericarpium Citri junoris tincture 15-25 part
The optimum weight proportioning of medicine of the present invention is:
30 parts of 150 portions of nanometer Radix Platycodonis fluidextracts of nanometer Radix Glycyrrhizae fluid extract
20 parts of 10 parts of nanometer Pericarpium Citri junoris tinctures of nanometer ammonium chloride
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get child cough preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine for treating baby cough is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common XIAOER ZHIKE TANGJIANG preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, medicated wine, oral solution of nano medicine for treating baby cough etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the treatment of the diseases such as cough that infantile common cold causes, clinical efficacy significantly is better than traditional XIAOER ZHIKE TANGJIANG.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
30 parts of 150 portions of nanometer Radix Platycodonis fluidextracts of nanometer Radix Glycyrrhizae fluid extract
20 parts of 10 parts of nanometer Pericarpium Citri junoris tinctures of nanometer ammonium chloride
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is a 0.1-0.6 gram, and the patient takes 1-4 time every day, every day the 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
30 parts of 150 portions of nanometer Radix Platycodonis fluidextracts of nanometer Radix Glycyrrhizae fluid extract
20 parts of 10 parts of nanometer Pericarpium Citri junoris tinctures of nanometer ammonium chloride
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nano children's cough-relieving powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
30 parts of 150 portions of nanometer Radix Platycodonis fluidextracts of nanometer Radix Glycyrrhizae fluid extract
20 parts of 10 parts of nanometer Pericarpium Citri junoris tinctures of nanometer ammonium chloride
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nano children's cough-relieving membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine for treating baby cough is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Glycyrrhizae fluid extract 100-200 part nanometer Radix Platycodonis fluidextract 20-45 part
Nanometer ammonium chloride 5-15 part nanometer Pericarpium Citri junoris tincture 10-35 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano medicine for treating baby cough according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Glycyrrhizae fluid extract 120-180 part nanometer Radix Platycodonis fluidextract 25-35 part
Nanometer ammonium chloride 8-12 part nanometer Pericarpium Citri junoris tincture 15-25 part
3, nano medicine for treating baby cough according to claim 1, wherein the weight proportion of each nano raw material is:
30 parts of 150 portions of nanometer Radix Platycodonis fluidextracts of nanometer Radix Glycyrrhizae fluid extract
20 parts of 10 parts of nanometer Pericarpium Citri junoris tinctures of nanometer ammonium chloride
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine for treating baby cough.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine for treating baby cough; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100216 CN1363293A (en) | 2001-01-10 | 2001-01-10 | Nano medicine for treating baby cough and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100216 CN1363293A (en) | 2001-01-10 | 2001-01-10 | Nano medicine for treating baby cough and its preparing process |
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| Publication Number | Publication Date |
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| CN1363293A true CN1363293A (en) | 2002-08-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01100216 Pending CN1363293A (en) | 2001-01-10 | 2001-01-10 | Nano medicine for treating baby cough and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497221A (en) * | 2014-10-11 | 2016-04-20 | 山东淄博新达制药有限公司 | Preparation method of infantile antitussive granules |
-
2001
- 2001-01-10 CN CN 01100216 patent/CN1363293A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497221A (en) * | 2014-10-11 | 2016-04-20 | 山东淄博新达制药有限公司 | Preparation method of infantile antitussive granules |
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