CN1362218A - Nano Radix Isatidis medicine and its preparation - Google Patents
Nano Radix Isatidis medicine and its preparation Download PDFInfo
- Publication number
- CN1362218A CN1362218A CN 01100717 CN01100717A CN1362218A CN 1362218 A CN1362218 A CN 1362218A CN 01100717 CN01100717 CN 01100717 CN 01100717 A CN01100717 A CN 01100717A CN 1362218 A CN1362218 A CN 1362218A
- Authority
- CN
- China
- Prior art keywords
- chinese
- nano
- radix isatidis
- medicine
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present ivnention discloses a nano isatis root preparation medicine. It is made up by using the Chinese medicinal materials of nano isatis root as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of heat-clearing and toxic substances removing, removing heat from blood, sore-throat relieving, repercussive nano Radix Isatidis preparation medicine the invention still further relates to the method for this medication preparation.
Radix Isatidis granules is a kind of Chinese patent medicine of classics, mainly contain antibiotic, antiviral, antiendotoxin, antiinflammatory, effects such as raise immunity, be used for the epidemic febrile disease heating, pyretic toxicity is sent out speckle, sore throat, mumps, acute catarrhal conjunctivitis, erysipelas, carbuncle etc., but traditional Radix Isatidis granules absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Radix Isatidis preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Radix Isatidis preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
100 parts of nano Radix Isatidis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the particle size of the special construction----material of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Radix Isatidis granules nano powder with the instantaneous drying of hypersonic velocity jet
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Radix Isatidis preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common Radix Isatidis granules preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Radix Isatidis preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for upper respiratory tract infection, mumps, epidemic encephalitis type B, influenza, treatments such as infectious hepatitis, pink eye disease, herpes simplex keratitis, chronic pharyngitis, chickenpox, viral dermatosis, clinical efficacy significantly is better than traditional Radix Isatidis granules.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of nano Radix Isatidis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano material by preceding method:
100 parts of nano Radix Isatidis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano Radix Isatidis powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
100 parts of nano Radix Isatidis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano Radix Isatidis membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (4)
1, a kind of nano Radix Isatidis preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
100 parts of nano Radix Isatidis
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Radix Isatidis preparation medicine according to claim 1 is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
3, the pharmaceutical methods of nano Radix Isatidis preparation medicine according to claim 1 is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
4, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100717 CN1362218A (en) | 2001-01-08 | 2001-01-08 | Nano Radix Isatidis medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100717 CN1362218A (en) | 2001-01-08 | 2001-01-08 | Nano Radix Isatidis medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362218A true CN1362218A (en) | 2002-08-07 |
Family
ID=4651824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100717 Pending CN1362218A (en) | 2001-01-08 | 2001-01-08 | Nano Radix Isatidis medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362218A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552777A (en) * | 2012-02-15 | 2012-07-11 | 刘静 | Medicament for treating herpes simplex keratitis and preparation method thereof |
-
2001
- 2001-01-08 CN CN 01100717 patent/CN1362218A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552777A (en) * | 2012-02-15 | 2012-07-11 | 刘静 | Medicament for treating herpes simplex keratitis and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1362170A (en) | Nano body resistance-strengthening Zhenqi medicine and its preparation | |
| CN1362218A (en) | Nano Radix Isatidis medicine and its preparation | |
| CN1366933A (en) | Nano Qiyeshen'an preparation medicine and preparation method | |
| CN1362199A (en) | Nano girald daphne medicine and its preparation | |
| CN1362191A (en) | Nano Folium Ginkgo medicine and its preparation | |
| CN1362102A (en) | Nano shengqi medicine and its preparation | |
| CN1360909A (en) | Nanometer cinobufagin medicine and its prepn | |
| CN1362141A (en) | Nano Xingxiao bezoar medicine and its preparation | |
| CN1362165A (en) | Nano spirulina medicine and its preparation | |
| CN1365794A (en) | Nano medicine 'Xingnaojing' and its preparing process | |
| CN1362171A (en) | Nano notoginseng medicine and its preparation | |
| CN1366978A (en) | Nane common cold-fever-abating preparation medicine and preparation method | |
| CN1363338A (en) | Nano medicine 'Donggui Buxue' and its preparing process | |
| CN1362135A (en) | Nano Capillary artemisia-cape jasmine-rhubarb medicine and its preparation | |
| CN1363297A (en) | Nano medicine 'Anluotong' and its preparing process | |
| CN1363348A (en) | Nano medicine 'Pulean' and its preparing process | |
| CN1363322A (en) | Nano medicine 'Yinhuang' and its preparing process | |
| CN1364518A (en) | Nano pittecellobium clypearia Benth anti-imflammatory medicine and its preparing method | |
| CN1362219A (en) | Nano Zhichuanling medicine for treating asthma and its preparation | |
| CN1362245A (en) | Nano medicine for Aucklandiae, coptidis and evodiae and its preparation | |
| CN1362099A (en) | Nano kangfuxin medicine and its preparation | |
| CN1362208A (en) | Nano astragalus medicine and its preparation | |
| CN1366943A (en) | Nano bupleurum preparation medicine and preparation method | |
| CN1362172A (en) | Nano dyspneic cough eliminating medicine and its preparation | |
| CN1363339A (en) | Nano medicine 'Compound Kendir' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |