CN1360936A - Nanometer Yunnan Baiyao medicine and its prepn - Google Patents
Nanometer Yunnan Baiyao medicine and its prepn Download PDFInfo
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- CN1360936A CN1360936A CN 00136932 CN00136932A CN1360936A CN 1360936 A CN1360936 A CN 1360936A CN 00136932 CN00136932 CN 00136932 CN 00136932 A CN00136932 A CN 00136932A CN 1360936 A CN1360936 A CN 1360936A
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Abstract
The nano Yunnan Paiyao medicine is prepared with nano Yunnan Paiyao as material. It has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm and mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and high treating effect.
Description
The present invention relates to a kind of removing stasis to stop bleeding, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling, cure mainly traumatic injury, nanometer YUNNAN BAIYAO preparation medicine that congestion is hemorrhage, the invention still further relates to the method for this medication preparation.
YUNNAN BAIYAO is a kind of classical Chinese patent medicine, mainly contain effects such as removing stasis to stop bleeding, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling, be used for traumatic injury, swelling and pain due to blood stasis, haematemesis, hemoptysis, have blood in stool, hemorrhoidal bleeding, metrostaxis, sore swollen toxin and soft tissue injury, closed fracture, bronchiectasis and pulmonary tuberculosis hemoptysis, ulcer haemorrhage, and skin infection disease.But traditional YUNNAN BAIYAO disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer YUNNAN BAIYAO preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer YUNNAN BAIYAO preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
100 parts of nanometer YUNNAN BAIYAO
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the special construction of nano material------material grains size is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get YUNNAN BAIYAO preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer YUNNAN BAIYAO preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common YUNNAN BAIYAO preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, tablet, suppository, membrane, microcapsule, drop pill, injection, unguentum, oral solution of nanometer YUNNAN BAIYAO preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for traumatic injury, swelling and pain due to blood stasis, haematemesis, hemoptysis, has blood in stool, hemorrhoidal bleeding, metrostaxis, sore swollen toxin and soft tissue injury, closed fracture, bronchiectasis and pulmonary tuberculosis hemoptysis, ulcer haemorrhage, and treatment of conditions such as skin infection disease, clinical efficacy significantly is better than traditional YUNNAN BAIYAO.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment:
Prepare nano raw material by preceding method:
100 parts of nanometer YUNNAN BAIYAO
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of nanometer YUNNAN BAIYAO
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer YUNNAN BAIYAO powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
100 parts of nanometer YUNNAN BAIYAO
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer YUNNAN BAIYAO membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest and affected part.
Claims (4)
1, a kind of nanometer YUNNAN BAIYAO preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
100 parts of nanometer YUNNAN BAIYAO
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer YUNNAN BAIYAO preparation medicine according to claim 1 is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
3, the pharmaceutical methods of nanometer YUNNAN BAIYAO preparation medicine according to claim 1 is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
4, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136932 CN1360936A (en) | 2000-12-29 | 2000-12-29 | Nanometer Yunnan Baiyao medicine and its prepn |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136932 CN1360936A (en) | 2000-12-29 | 2000-12-29 | Nanometer Yunnan Baiyao medicine and its prepn |
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| Publication Number | Publication Date |
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| CN1360936A true CN1360936A (en) | 2002-07-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 00136932 Pending CN1360936A (en) | 2000-12-29 | 2000-12-29 | Nanometer Yunnan Baiyao medicine and its prepn |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948543A (en) * | 2014-05-11 | 2014-07-30 | 张晓燕 | Yunnan white powder nanoemulsion and preparation method thereof |
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2000
- 2000-12-29 CN CN 00136932 patent/CN1360936A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948543A (en) * | 2014-05-11 | 2014-07-30 | 张晓燕 | Yunnan white powder nanoemulsion and preparation method thereof |
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