CN1362089A - Nano sanhuang medicine and its preparation - Google Patents
Nano sanhuang medicine and its preparation Download PDFInfo
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- CN1362089A CN1362089A CN 01100073 CN01100073A CN1362089A CN 1362089 A CN1362089 A CN 1362089A CN 01100073 CN01100073 CN 01100073 CN 01100073 A CN01100073 A CN 01100073A CN 1362089 A CN1362089 A CN 1362089A
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Abstract
The invention discloses a nan three huang preparation. It comprises nano Chinese goldthread, nano Radix scutellariae and nano rhubarb as materials, making up in proportion and to be fabricated into new medicine drug. Its particles fineness is 1200-1500 mesh and particle size 0.1-200nm and most of the particle size is shorter than 100nm and has new material properties. It is fabricated through steps such as microwave extraction, decompression and concentration supersonic jet and spray drying.
Description
The present invention relates to a kind of eliminating fire and detoxication, the dampness pain relieving, the nanometer three yellow preparation medicine of removing heat from blood the invention still further relates to the method for this medication preparation.
SANHUANG PIAN is a kind of Chinese patent medicine of classics, mainly contains antibacterial anti-inflammatory, hemostasis, and blood pressure lowering, effects such as diarrhea inducing are used to tell nosebleed and have blood in stool, the jaundice feeling of fullness, the conjunctival congestion aphtha, the surgery skin ulcer is swollen etc.But traditional SANHUANG PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer three yellow preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer three yellow preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
The formula optimization of nanometer coptis 80-120 part nanometer Radix Scutellariae 80-120 part nano rhubarb 80-120 part medicine of the present invention
The weight proportion scope is:
Nanometer coptis 90-110 part nanometer Radix Scutellariae 90-110 part nano rhubarb 90-110 part
The optimum weight proportioning of medicine of the present invention is:
100 parts of 100 parts of nano rhubarbs of 100 parts of nanometer Radix Scutellariaes of nanometer coptis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the particle size of the special construction----material of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05MPa under the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, 0-0.05MPa under the pressure,, get the three yellow preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer three yellow preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common SANHUANG PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer three yellow preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for hemorrhage, acute pulmonary infection, chronic osteomyelitis, chronic pelvic inflammatory disease, vaginitis, cervical erosion, the anus hemorrhoid patients, facial paralysis, acne vulgaris, suppurative arthritis, seriality finger tip inflammation, seborrheic dermatitis, treatments such as acid regurgitation, clinical efficacy significantly is better than traditional SANHUANG PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 100 parts of nano rhubarbs of 100 parts of nanometer Radix Scutellariaes of nanometer coptis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano material by preceding method:
100 parts of 100 parts of nano rhubarbs of 100 parts of nanometer Radix Scutellariaes of nanometer coptis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer SANHUANGFEN needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
100 parts of 100 parts of nano rhubarbs of 100 parts of nanometer Radix Scutellariaes of nanometer coptis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer SANHUANG membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer three yellow preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
Nanometer coptis 80-120 part nanometer Radix Scutellariae 80-120 part nano rhubarb 80-120 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer three yellow preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer coptis 90-110 part nanometer Radix Scutellariae 90-110 part nano rhubarb 90-110 part
3, nanometer three yellow preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts of 100 parts of nano rhubarbs of 100 parts of nanometer Radix Scutellariaes of nanometer coptis
4, according to claim 1 or 2 or 3 described nanometer three yellow preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer three yellow preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, 0-0.05MPa under the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100073 CN1362089A (en) | 2001-01-08 | 2001-01-08 | Nano sanhuang medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100073 CN1362089A (en) | 2001-01-08 | 2001-01-08 | Nano sanhuang medicine and its preparation |
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| CN1362089A true CN1362089A (en) | 2002-08-07 |
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| CN 01100073 Pending CN1362089A (en) | 2001-01-08 | 2001-01-08 | Nano sanhuang medicine and its preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105169033A (en) * | 2015-09-09 | 2015-12-23 | 济南舜昊生物科技有限公司 | Medicament for treating heat disturbing mind type pediatric acute pyogenic osteomyelitis and preparation method of medicament |
| CN110123911A (en) * | 2018-02-02 | 2019-08-16 | 刘光毕 | A kind of Chinese medicine suppository and preparation method thereof for treating chronic pelvic inflammatory disease |
-
2001
- 2001-01-08 CN CN 01100073 patent/CN1362089A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105169033A (en) * | 2015-09-09 | 2015-12-23 | 济南舜昊生物科技有限公司 | Medicament for treating heat disturbing mind type pediatric acute pyogenic osteomyelitis and preparation method of medicament |
| CN110123911A (en) * | 2018-02-02 | 2019-08-16 | 刘光毕 | A kind of Chinese medicine suppository and preparation method thereof for treating chronic pelvic inflammatory disease |
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